SIMILAR PATTERNS OF AMINO ACIDS FOR 3GWV_A_RFXA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ae9 LAMBDA INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase) 		5 LEU A 331
GLY A 332
LEU A 330
LEU A 216
ASP A 215
 None
 1.03A 3gwvA-1ae9A:
undetectable		 3gwvA-1ae9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 LEU A 281
GLY A 279
LEU A 132
ARG A 280
ASP A 151
 None
 0.99A 3gwvA-1cj2A:
0.0		 3gwvA-1cj2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 LEU P 157
GLY P 156
LEU P 151
ALA P 126
LEU P 144
 None
 0.98A 3gwvA-1e4aP:
0.0		 3gwvA-1e4aP:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exb KV BETA2 PROTEIN

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		5 LEU A  52
GLY A  53
LEU A 322
ILE A 334
ALA A 324
 None
None
None
None
NDP  A1000 ( 4.9A)
 1.02A 3gwvA-1exbA:
0.0		 3gwvA-1exbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 991
GLY A 905
LEU A 877
ILE A 988
ALA A 879
 None
None
None
None
AKG  A2510 (-3.6A)
 1.05A 3gwvA-1ofeA:
0.0		 3gwvA-1ofeA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxy FIMBRIN-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF00307
(CH) 		5 LEU A 169
LEU A 166
ILE A 133
LEU A 147
ASP A 140
 None
 0.97A 3gwvA-1pxyA:
0.0		 3gwvA-1pxyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw2 CONSERVED
HYPOTHETICAL PROTEIN
TA1206

(Thermoplasma
acidophilum) 		PF08827
(DUF1805) 		5 GLY A  29
TYR A  33
ILE A  26
LEU A  81
ASP A  82
 None
 0.86A 3gwvA-1qw2A:
undetectable		 3gwvA-1qw2A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 419
GLY A 418
ILE A 128
ALA A 166
LEU A 175
 None
 1.03A 3gwvA-1r9jA:
0.0		 3gwvA-1r9jA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LEU A 430
GLY A 431
PHE A 403
ALA A 449
LEU A 387
 None
 0.71A 3gwvA-1tf0A:
0.0		 3gwvA-1tf0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 GLY A 216
LEU A 214
GLN A 212
ILE A 178
ALA A 210
 None
 1.05A 3gwvA-1to3A:
undetectable		 3gwvA-1to3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3d CRYPTOCHROME 1
APOPROTEIN

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A  77
GLY A  78
ALA A  41
LEU A  70
ASP A  71
 None
 0.89A 3gwvA-1u3dA:
undetectable		 3gwvA-1u3dA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3t LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE/PROSTAGLANDIN
15-KETO REDUCTASE

(Cavia porcellus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 133
GLY A 132
LEU A 134
ILE A 161
ALA A 283
 None
 0.96A 3gwvA-1v3tA:
undetectable		 3gwvA-1v3tA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6f ARYLAMINE
N-ACETYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF00797
(Acetyltransf_2) 		5 LEU A  14
GLY A  13
LEU A   9
ILE A  28
LEU A  77
 None
 1.04A 3gwvA-1w6fA:
undetectable		 3gwvA-1w6fA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 162
LEU A 160
ILE A  99
ALA A 419
LEU A 166
 None
 1.05A 3gwvA-1xmbA:
undetectable		 3gwvA-1xmbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yaa ASPARTATE
AMINOTRANSFERASE

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 LEU A 174
GLY A 172
LEU A 170
ILE A 208
LEU A 188
 None
 0.95A 3gwvA-1yaaA:
undetectable		 3gwvA-1yaaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9c ORGANIC
HYDROPEROXIDE
RESISTANCE
TRANSCRIPTIONAL
REGULATOR

(Bacillus
subtilis) 		PF01047
(MarR) 		5 LEU A  83
GLY A 104
LEU A 107
ILE A  38
ALA A 111
 None
 1.03A 3gwvA-1z9cA:
undetectable		 3gwvA-1z9cA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU A 366
GLY A 398
LEU A 293
ARG A 399
ILE A 382
 None
 1.05A 3gwvA-1zkcA:
undetectable		 3gwvA-1zkcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Bacillus
subtilis) 		PF01182
(Glucosamine_iso) 		5 LEU A  32
ILE A  24
PHE A  88
ALA A  17
LEU A  56
 None
 1.04A 3gwvA-2bkxA:
undetectable		 3gwvA-2bkxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		5 LEU A  73
GLY A  72
ILE A  60
ALA A  21
LEU A  57
 None
 0.98A 3gwvA-2cbnA:
undetectable		 3gwvA-2cbnA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g76 D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  50
GLY A  49
LEU A   9
PHE A 302
LEU A  14
 None
 0.86A 3gwvA-2g76A:
undetectable		 3gwvA-2g76A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		5 LEU A 471
GLY A 472
LEU A 468
ALA A 425
LEU A 368
 None
 1.02A 3gwvA-2ja2A:
undetectable		 3gwvA-2ja2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 142
GLY A 141
LEU A 113
ILE A 102
LEU A  79
 None
 0.96A 3gwvA-2nq3A:
undetectable		 3gwvA-2nq3A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qwt TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
vanbaalenii) 		PF00440
(TetR_N) 		5 LEU A 129
GLY A 130
LEU A 132
ALA A 136
LEU A 180
 None
 0.93A 3gwvA-2qwtA:
undetectable		 3gwvA-2qwtA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		5 LEU A 123
LEU A 262
ARG A 122
ILE A 101
ALA A 152
 None
None
MPD  A1299 (-3.7A)
None
MPD  A1299 ( 3.9A)
 1.00A 3gwvA-2vy0A:
undetectable		 3gwvA-2vy0A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhe UNC18

(Monosiga
brevicollis) 		PF00995
(Sec1) 		6 LEU A 422
LEU A 425
TYR A 440
ILE A 439
ALA A 429
LEU A 404
 None
 1.49A 3gwvA-2xheA:
undetectable		 3gwvA-2xheA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU C  34
ILE C  36
PHE C  11
ALA C 237
LEU C  18
 None
 0.99A 3gwvA-3aizC:
undetectable		 3gwvA-3aizC:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN

(Bifidobacterium
longum) 		PF02541
(Ppx-GppA) 		5 LEU A  90
GLY A  89
ALA A  33
LEU A 329
ASP A 330
 None
 0.79A 3gwvA-3cerA:
undetectable		 3gwvA-3cerA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 GLY A 206
LEU A 203
ILE A 277
LEU A 244
ASP A 246
 None
 0.86A 3gwvA-3djlA:
undetectable		 3gwvA-3djlA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enp TP53RK-BINDING
PROTEIN

(Homo sapiens) 		PF08617
(CGI-121) 		5 GLY A  27
LEU A  29
ARG A  30
ILE A 105
ALA A  33
 None
 1.02A 3gwvA-3enpA:
undetectable		 3gwvA-3enpA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A  80
GLY A  81
LEU A 185
LEU A  73
ASP A  74
 None
 0.94A 3gwvA-3fy4A:
undetectable		 3gwvA-3fy4A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 109
LEU A 108
LEU A 142
ASP A 139
ASP A 135
 None
 1.03A 3gwvA-3i58A:
undetectable		 3gwvA-3i58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lti DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Escherichia
coli) 		PF04561
(RNA_pol_Rpb2_2) 		5 LEU A 213
LEU A 210
ILE A 425
ALA A 206
LEU A 184
 MLY  A 422 ( 4.1A)
None
MLY  A 422 ( 4.1A)
None
None
 1.05A 3gwvA-3ltiA:
undetectable		 3gwvA-3ltiA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		12 LEU A  25
GLY A  26
LEU A  29
ARG A  30
GLN A  34
TYR A 108
ILE A 111
PHE A 253
ALA A 319
LEU A 400
ASP A 401
ASP A 404
 LEU  A 601 (-4.9A)
LEU  A 601 (-3.1A)
None
None
None
LEU  A 601 (-4.5A)
None
LEU  A 601 (-4.2A)
None
None
None
None
 0.31A 3gwvA-3mpnA:
68.0		 3gwvA-3mpnA:
99.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxu GLYCINE CLEAVAGE
SYSTEM H PROTEIN

(Bartonella
henselae) 		PF01597
(GCV_H) 		5 LEU A  32
GLY A  33
LEU A  35
ILE A  24
ASP A  26
 None
 1.00A 3gwvA-3mxuA:
undetectable		 3gwvA-3mxuA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		PF02645
(DegV) 		5 LEU A 131
GLY A 129
ILE A 152
ALA A 136
LEU A  85
 None
 1.02A 3gwvA-3pl5A:
undetectable		 3gwvA-3pl5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 GLY A 178
LEU A 181
ILE A  52
ALA A 185
LEU A 135
 None
 1.00A 3gwvA-3pshA:
undetectable		 3gwvA-3pshA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 LEU A 167
GLY A 168
ILE A 124
ALA A 131
LEU A 101
 None
 0.89A 3gwvA-3qc0A:
undetectable		 3gwvA-3qc0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo7 SERYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Candida
albicans) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 LEU A 332
GLY A 331
LEU A 330
ILE A 415
LEU A 425
 None
 1.02A 3gwvA-3qo7A:
undetectable		 3gwvA-3qo7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjv PUTATIVE SEL1 REPEAT
PROTEIN

(Klebsiella
pneumoniae) 		PF08238
(Sel1) 		5 LEU A 149
GLY A 148
LEU A 146
GLN A 144
PHE A 168
 None
 0.97A 3gwvA-3rjvA:
undetectable		 3gwvA-3rjvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 5 LEU K  10
GLY K   7
GLN K   5
ILE K  13
LEU J 104
 None
 0.90A 3gwvA-3rkoK:
undetectable		 3gwvA-3rkoK:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 LEU K  35
GLY K  34
LEU K  32
ILE N 161
LEU L 591
 None
 0.91A 3gwvA-3rkoK:
undetectable		 3gwvA-3rkoK:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sip CASPASE

(Drosophila
melanogaster) 		PF00656
(Peptidase_C14) 		5 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.98A 3gwvA-3sipA:
undetectable		 3gwvA-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snk RESPONSE REGULATOR
CHEY-LIKE PROTEIN

(Mesorhizobium
loti) 		no annotation 6 LEU A  72
GLY A  69
LEU A  66
ILE A  77
LEU A  50
ASP A  47
 None
 1.34A 3gwvA-3snkA:
undetectable		 3gwvA-3snkA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 LEU A  33
GLY A  34
ILE A  31
ALA A  75
ASP A  83
 None
 0.92A 3gwvA-3tfoA:
undetectable		 3gwvA-3tfoA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqx 2-AMINO-3-KETOBUTYRA
TE COENZYME A LIGASE

(Coxiella
burnetii) 		PF00155
(Aminotran_1_2) 		5 GLY A 180
ILE A 194
PHE A 182
ALA A 177
LEU A 159
 None
 0.97A 3gwvA-3tqxA:
undetectable		 3gwvA-3tqxA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 5 LEU A 313
LEU A 316
TYR A  90
ALA A 190
ASP A 162
 None
 1.02A 3gwvA-3wweA:
undetectable		 3gwvA-3wweA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 LEU A 174
GLY A 172
LEU A 170
ILE A 208
LEU A 188
 None
 0.74A 3gwvA-3wzfA:
undetectable		 3gwvA-3wzfA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zua ALPHA-HEMOLYSIN
TRANSLOCATION
ATP-BINDING PROTEIN
HLYB

(Escherichia
coli) 		PF03412
(Peptidase_C39) 		5 LEU A  11
GLY A  10
LEU A  41
ILE A  30
LEU A  53
 None
 0.91A 3gwvA-3zuaA:
undetectable		 3gwvA-3zuaA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		5 LEU X 231
GLY X 232
LEU X 222
ALA X 210
LEU X 583
 None
 0.87A 3gwvA-3zyyX:
undetectable		 3gwvA-3zyyX:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 LEU A 257
ILE A 162
PHE A 144
ALA A 159
LEU A 214
 None
 1.03A 3gwvA-3zzuA:
undetectable		 3gwvA-3zzuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5q CHI1

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		5 GLY A 493
LEU A 495
ILE A 485
PHE A  59
ALA A 499
 None
 1.04A 3gwvA-4a5qA:
undetectable		 3gwvA-4a5qA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		5 LEU A 214
LEU A 353
ARG A 213
ILE A 193
ALA A 240
 None
None
BGC  A 402 ( 3.9A)
None
GLC  A 401 ( 3.5A)
 1.03A 3gwvA-4bpzA:
undetectable		 3gwvA-4bpzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 LEU I 231
GLY I 232
LEU I 222
ALA I 210
LEU I 583
 None
 0.86A 3gwvA-4c1nI:
undetectable		 3gwvA-4c1nI:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccs CBIX

(Paracoccus
pantotrophus) 		PF01903
(CbiX) 		5 LEU A  98
GLY A  97
LEU A 101
ALA A 104
LEU A 146
 None
 0.99A 3gwvA-4ccsA:
undetectable		 3gwvA-4ccsA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgv CHROMOSOME REGION
MAINTENANCE 1 (CRM1)
OR EXPORTIN 1 (XPO1)

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 777
GLY A 776
LEU A 778
ILE A 804
LEU A 808
 None
 1.04A 3gwvA-4fgvA:
undetectable		 3gwvA-4fgvA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 585
GLY A 584
LEU A 588
ALA A 591
LEU A 600
 None
 1.02A 3gwvA-4fwgA:
undetectable		 3gwvA-4fwgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.04A 3gwvA-4gekA:
undetectable		 3gwvA-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		5 GLY A 178
ILE A 228
ALA A 216
LEU A 245
ASP A 241
 None
 1.00A 3gwvA-4h3zA:
undetectable		 3gwvA-4h3zA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hr6 LECTIN

(Trichosanthes
anguina) 		PF00161
(RIP) 		5 LEU B  53
LEU B  65
TYR B  51
ILE B  67
ALA B  76
 None
 1.04A 3gwvA-4hr6B:
undetectable		 3gwvA-4hr6B:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 GLY A 245
LEU A 248
ARG A 100
ILE A 238
ALA A 252
 None
 0.97A 3gwvA-4iwhA:
undetectable		 3gwvA-4iwhA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE

(Escherichia
coli) 		PF13649
(Methyltransf_25) 		5 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.05A 3gwvA-4iwnA:
undetectable		 3gwvA-4iwnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8k HYPOTHETICAL
PROTEIN, GDSL-LIKE
LIPASE/ACYLHYDROLASE
FAMILY PROTEIN

(Bacteroides
uniformis) 		PF16255
(Lipase_GDSL_lke) 		5 LEU A 112
GLY A 113
TYR A 164
ILE A 118
ASP A 116
 None
 1.01A 3gwvA-4m8kA:
undetectable		 3gwvA-4m8kA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		5 LEU A 115
GLY A 114
LEU A 112
GLN A 110
ILE A 136
 None
None
None
GOL  A 407 (-3.0A)
None
 0.86A 3gwvA-4p3zA:
undetectable		 3gwvA-4p3zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		5 LEU A  63
GLY A  64
LEU A  20
GLN A  75
ILE A  55
 None
 0.92A 3gwvA-4rckA:
undetectable		 3gwvA-4rckA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rck HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Aliivibrio
fischeri) 		PF00092
(VWA) 		5 LEU A  63
GLY A  64
LEU A  20
ILE A  55
ASP A  90
 None
 0.76A 3gwvA-4rckA:
undetectable		 3gwvA-4rckA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 LEU A 261
GLY A 262
GLN A 264
PHE A 263
LEU A 226
 None
 1.04A 3gwvA-4rf7A:
undetectable		 3gwvA-4rf7A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		6 LEU A  29
GLY A  30
ARG A  34
TYR A 108
ILE A 111
PHE A 230
 None
TRP  A 601 (-3.1A)
None
TRP  A 601 (-4.8A)
None
TRP  A 601 (-4.4A)
 0.62A 3gwvA-4us4A:
41.0		 3gwvA-4us4A:
33.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		7 LEU A  29
GLY A  30
TYR A 108
ILE A 111
PHE A 230
ASP A 382
ASP A 385
 None
TRP  A 601 (-3.1A)
TRP  A 601 (-4.8A)
None
TRP  A 601 (-4.4A)
None
None
 0.71A 3gwvA-4us4A:
41.0		 3gwvA-4us4A:
33.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z3k SEPIAPTERIN
REDUCTASE

(Homo sapiens) 		PF00106
(adh_short) 		6 LEU A  27
GLY A   1
LEU A   2
GLN A  90
ALA A   5
LEU A  58
 None
 1.26A 3gwvA-4z3kA:
undetectable		 3gwvA-4z3kA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aip TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Neisseria
meningitidis) 		PF01047
(MarR) 		5 LEU A  71
GLY A  69
LEU A  67
ILE A  41
ASP A  36
 None
 0.85A 3gwvA-5aipA:
undetectable		 3gwvA-5aipA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		5 LEU A 499
GLY A 497
ILE A 381
LEU A 506
ASP A 505
 None
 1.01A 3gwvA-5bu1A:
undetectable		 3gwvA-5bu1A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0n PYRUVATE, PHOSPHATE
DIKINASE REGULATORY
PROTEIN,
CHLOROPLASTIC

(Zea mays) 		PF03618
(Kinase-PPPase) 		5 LEU A 410
GLY A 408
LEU A 407
ILE A 289
LEU A 291
 None
 0.86A 3gwvA-5d0nA:
undetectable		 3gwvA-5d0nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 LEU A 258
GLY A 257
LEU A 237
ALA A 212
LEU A 150
 None
 0.93A 3gwvA-5ereA:
undetectable		 3gwvA-5ereA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1m PHOSPHORYLATED
PROTEIN PHOSPHATASE

(Staphylococcus
aureus) 		PF13672
(PP2C_2) 		5 GLY A 219
LEU A 222
GLN A 224
ALA A 226
ASP A   9
 None
 1.03A 3gwvA-5f1mA:
undetectable		 3gwvA-5f1mA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A  51
GLY A  49
TYR A 109
ILE A 103
ALA A  41
 None
 1.01A 3gwvA-5f5oA:
undetectable		 3gwvA-5f5oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 543
GLY A 207
LEU A 245
ILE A 638
ASP A 216
 None
 1.03A 3gwvA-5f7cA:
undetectable		 3gwvA-5f7cA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU B  34
GLY B  35
ILE B 427
ALA B 457
LEU B 464
 None
 0.96A 3gwvA-5fbhB:
undetectable		 3gwvA-5fbhB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo5 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR METR

(Escherichia
coli) 		PF00126
(HTH_1) 		6 LEU A  48
GLY A  62
LEU A  65
GLN A  67
PHE A  58
ALA A  69
 None
 1.20A 3gwvA-5fo5A:
undetectable		 3gwvA-5fo5A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		5 LEU A 371
GLY A 370
LEU A 369
ILE A 334
ALA A 265
 None
 0.99A 3gwvA-5fvdA:
undetectable		 3gwvA-5fvdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 LEU A 264
ARG A 265
ILE A 337
ALA A 269
LEU A 323
 None
 0.94A 3gwvA-5fxeA:
undetectable		 3gwvA-5fxeA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		5 LEU A 430
GLY A 431
PHE A 403
ALA A 449
LEU A 387
 None
 0.86A 3gwvA-5ghkA:
undetectable		 3gwvA-5ghkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		5 LEU A 379
GLY A 376
PHE A 348
LEU A 357
ASP A 352
 None
 0.89A 3gwvA-5gmxA:
undetectable		 3gwvA-5gmxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5haf DEUBIQUITINASE SSEL

(Salmonella
enterica) 		no annotation 5 LEU A 172
GLY A 171
TYR A 290
ILE A 293
LEU A 217
 None
 1.04A 3gwvA-5hafA:
undetectable		 3gwvA-5hafA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbr UNCHARACTERIZED
PROTEIN BCAV_2135

(Beutenbergia
cavernae) 		PF12802
(MarR_2) 		5 LEU A  48
GLY A  45
LEU A  50
TYR A  31
LEU A  62
 None
 1.03A 3gwvA-5jbrA:
undetectable		 3gwvA-5jbrA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A  34
GLY A  35
ILE A 427
ALA A 457
LEU A 464
 None
 1.02A 3gwvA-5k5tA:
undetectable		 3gwvA-5k5tA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzl HEME OXYGENASE

(Leptospira
interrogans) 		PF01126
(Heme_oxygenase) 		5 GLY A 133
LEU A 136
ALA A 140
LEU A  41
ASP A  81
 None
HEM  A 301 (-4.7A)
None
None
None
 0.98A 3gwvA-5kzlA:
2.8		 3gwvA-5kzlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ms7 LEGIONELLA
PNEUMOPHILA EFFECTOR
PROTEIN RAVZ

(Legionella
pneumophila) 		no annotation 5 LEU A  71
LEU A  74
ILE A 301
ALA A  81
LEU A 293
 None
 0.96A 3gwvA-5ms7A:
undetectable		 3gwvA-5ms7A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6c D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 5 LEU A  51
GLY A  50
LEU A  10
PHE A 303
LEU A  15
 None
 0.85A 3gwvA-5n6cA:
undetectable		 3gwvA-5n6cA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
G

(Methanothermococcus
thermolithotrophicus) 		PF01058
(Oxidored_q6)
PF02662
(FlpD) 		5 LEU E  94
GLY E  93
ILE E 281
ALA E 292
LEU D  95
 None
 0.97A 3gwvA-5odrE:
undetectable		 3gwvA-5odrE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 LEU A 205
GLN A 211
ILE A 146
PHE A 244
LEU A 158
 None
 0.92A 3gwvA-5opjA:
undetectable		 3gwvA-5opjA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 383
ARG A 385
GLN A 381
ILE A 349
PHE A 317
 None
 1.03A 3gwvA-5tvjA:
undetectable		 3gwvA-5tvjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wai POLYCOMB PROTEIN
SUZ12

(Homo sapiens) 		no annotation 5 GLY B 484
TYR B 478
ILE B 487
ALA B 444
LEU B 467
 None
 1.03A 3gwvA-5waiB:
undetectable		 3gwvA-5waiB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whr INDOLEAMINE
2,3-DIOXYGENASE 1

(Homo sapiens) 		no annotation 5 LEU A 277
GLY A 278
LEU A 276
TYR A 332
LEU A 196
 None
 0.95A 3gwvA-5whrA:
undetectable		 3gwvA-5whrA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y92 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 181
LEU A 104
TYR A  90
ILE A 164
LEU A 162
 None
 0.97A 3gwvA-5y92A:
undetectable		 3gwvA-5y92A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y96 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR1

(Arabidopsis
thaliana) 		no annotation 5 GLY B 180
LEU B 103
TYR B  89
ILE B 163
LEU B 161
 None
 0.95A 3gwvA-5y96B:
undetectable		 3gwvA-5y96B:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LEU A 430
GLY A 431
PHE A 403
ALA A 449
LEU A 387
 None
 0.95A 3gwvA-5yxeA:
undetectable		 3gwvA-5yxeA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 281
GLY A 279
LEU A 132
ILE A 155
ASP A 151
 None
 0.99A 3gwvA-6dllA:
undetectable		 3gwvA-6dllA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 6 LEU J 143
GLY J 144
ARG J  46
ILE J  59
ALA J  49
ASP J 153
 None
 1.13A 3gwvA-6fhsJ:
undetectable		 3gwvA-6fhsJ:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 LEU A1185
GLY A1184
LEU A1186
ILE A1144
ALA A1208
 None
 1.02A 3gwvA-6fikA:
undetectable		 3gwvA-6fikA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B
GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Homo sapiens) 		no annotation 5 LEU A 343
GLY A 342
LEU A 338
ILE S 231
ALA S 150
 None
 1.05A 3gwvA-6g79A:
undetectable		 3gwvA-6g79A:
10.53