SIMILAR PATTERNS OF AMINO ACIDS FOR 3GV1_B_BEZB303_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)


(Ipomoea batatas)
PF00264
(Tyrosinase)
PF12142
(PPO1_DWL)
4 LEU A 307
ALA A  32
VAL A  31
PRO A  30
None
1.16A 3gv1B-1bt2A:
undetectable
3gv1B-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus)
PF06393
(BID)
4 LEU A  38
ALA A 160
VAL A 159
PRO A 164
None
1.15A 3gv1B-1ddbA:
undetectable
3gv1B-1ddbA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1djp GLUTAMINASE-ASPARAGI
NASE


(Pseudomonas sp.
7A)
PF00710
(Asparaginase)
4 LEU A1330
ALA A1248
VAL A1224
PRO A1222
None
1.01A 3gv1B-1djpA:
undetectable
3gv1B-1djpA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli)
no annotation 4 LEU Y 191
ALA Y 186
VAL Y 217
PRO Y 215
None
0.93A 3gv1B-1gllY:
0.0
3gv1B-1gllY:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E


(Trichoderma
reesei)
PF01532
(Glyco_hydro_47)
4 LEU A 181
ALA A 147
VAL A 159
PRO A 157
None
1.03A 3gv1B-1hcuA:
undetectable
3gv1B-1hcuA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)


(Archaeoglobus
fulgidus)
PF01656
(CbiA)
4 LEU A  92
ALA A  39
VAL A  37
PRO A  84
None
0.98A 3gv1B-1hyqA:
0.0
3gv1B-1hyqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE


(Escherichia
coli)
PF00596
(Aldolase_II)
4 LEU A 167
ALA A 194
VAL A 193
PRO A 112
None
1.13A 3gv1B-1jdiA:
0.0
3gv1B-1jdiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrococcus
furiosus)
PF01135
(PCMT)
4 LEU A 175
ALA A 168
VAL A 189
PRO A 188
None
1.15A 3gv1B-1jg3A:
undetectable
3gv1B-1jg3A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jj7 PEPTIDE TRANSPORTER
TAP1


(Homo sapiens)
PF00005
(ABC_tran)
4 LEU A 673
ALA A 669
VAL A 584
PRO A 588
None
1.10A 3gv1B-1jj7A:
0.0
3gv1B-1jj7A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kr5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Homo sapiens)
PF01135
(PCMT)
4 LEU A 168
ALA A 161
VAL A 182
PRO A 181
None
1.11A 3gv1B-1kr5A:
undetectable
3gv1B-1kr5A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE


(Escherichia
coli)
PF13406
(SLT_2)
4 LEU A 315
ALA A 272
VAL A 271
PRO A 330
None
1.05A 3gv1B-1ltmA:
undetectable
3gv1B-1ltmA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA


(Geobacillus
stearothermophilus)
PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
4 LEU A 570
ALA A 355
VAL A 575
PRO A 573
None
1.12A 3gv1B-1qhgA:
undetectable
3gv1B-1qhgA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu0 LAMININ ALPHA2 CHAIN

(Mus musculus)
PF02210
(Laminin_G_2)
4 LEU A2974
ALA A2948
VAL A2949
PRO A3059
None
1.04A 3gv1B-1qu0A:
undetectable
3gv1B-1qu0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r18 PROTEIN-L-ISOASPARTA
TE(D-ASPARTATE)-O-ME
THYLTRANSFERASE


(Drosophila
melanogaster)
PF01135
(PCMT)
4 LEU A 174
ALA A 167
VAL A 188
PRO A 187
None
1.02A 3gv1B-1r18A:
undetectable
3gv1B-1r18A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B


(Escherichia
coli)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A1035
ALA A1121
VAL A1019
PRO A1023
None
1.07A 3gv1B-1s16A:
undetectable
3gv1B-1s16A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc8 LYSINE BIOSYNTHESIS
ENZYME


(Thermus
thermophilus)
PF08443
(RimK)
4 LEU A  46
ALA A  52
VAL A  76
PRO A  75
None
1.15A 3gv1B-1uc8A:
1.6
3gv1B-1uc8A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE


(Thermus
thermophilus)
PF00697
(PRAI)
4 LEU A  68
ALA A  79
VAL A  99
PRO A  98
None
1.17A 3gv1B-1v5xA:
undetectable
3gv1B-1v5xA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7p RRNA
METHYLTRANSFERASE


(Streptomyces
viridochromogenes)
PF00588
(SpoU_methylase)
4 LEU A 230
ALA A 158
VAL A 185
PRO A 188
None
1.24A 3gv1B-1x7pA:
undetectable
3gv1B-1x7pA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bn8 CELL DIVISION
ACTIVATOR CEDA


(Escherichia
coli)
PF10729
(CedA)
4 LEU A  61
ALA A  52
VAL A  51
PRO A  64
None
1.21A 3gv1B-2bn8A:
undetectable
3gv1B-2bn8A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
4 LEU A  83
ALA A  39
VAL A  12
PRO A   8
None
1.14A 3gv1B-2c4mA:
undetectable
3gv1B-2c4mA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7i POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 10


(Homo sapiens)
PF00535
(Glycos_transf_2)
PF00652
(Ricin_B_lectin)
4 LEU A 247
ALA A 323
VAL A 262
PRO A 264
None
1.00A 3gv1B-2d7iA:
undetectable
3gv1B-2d7iA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus)
PF01425
(Amidase)
4 LEU A 260
ALA A 401
VAL A 408
PRO A 399
None
1.08A 3gv1B-2dc0A:
undetectable
3gv1B-2dc0A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddu REELIN

(Mus musculus)
no annotation 4 LEU A1543
ALA A1375
VAL A1301
PRO A1412
None
1.23A 3gv1B-2dduA:
undetectable
3gv1B-2dduA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgw PROBABLE RNA-BINDING
PROTEIN 19


(Homo sapiens)
PF00076
(RRM_1)
4 LEU A 298
ALA A 349
VAL A 346
PRO A 319
None
1.07A 3gv1B-2dgwA:
undetectable
3gv1B-2dgwA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor)
PF00067
(p450)
4 LEU A 134
ALA A 158
VAL A 159
PRO A 156
None
1.23A 3gv1B-2dkkA:
undetectable
3gv1B-2dkkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf4 PROTEIN VNG1086C

(Halobacterium
salinarum)
PF01893
(UPF0058)
4 LEU A   6
ALA A  54
VAL A  39
PRO A  41
None
1.11A 3gv1B-2gf4A:
undetectable
3gv1B-2gf4A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz7 GLUTAMINYL-TRNA
SYNTHETASE


(Deinococcus
radiodurans)
PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C)
4 LEU A 376
ALA A 346
VAL A 347
PRO A 344
None
1.23A 3gv1B-2hz7A:
undetectable
3gv1B-2hz7A:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iih MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C


(Thermus
thermophilus)
PF01967
(MoaC)
4 LEU A  34
ALA A  41
VAL A  47
PRO A  52
None
1.24A 3gv1B-2iihA:
undetectable
3gv1B-2iihA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4p PROTEIN RS21-C6

(Mus musculus)
PF12643
(MazG-like)
4 LEU A 103
ALA A 107
VAL A 112
PRO A 115
None
1.15A 3gv1B-2q4pA:
undetectable
3gv1B-2q4pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4e MUTT/NUDIX FAMILY
PROTEIN


(Deinococcus
radiodurans)
PF00293
(NUDIX)
4 LEU A 187
ALA A  74
VAL A  68
PRO A  67
None
1.11A 3gv1B-2w4eA:
undetectable
3gv1B-2w4eA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus)
PF00079
(Serpin)
4 LEU A 150
ALA A  77
VAL A  80
PRO A 102
None
1.23A 3gv1B-2wxzA:
undetectable
3gv1B-2wxzA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142


(Mycobacterium
tuberculosis)
PF00067
(p450)
4 LEU A 113
ALA A 136
VAL A 137
PRO A 134
None
1.17A 3gv1B-2xkrA:
undetectable
3gv1B-2xkrA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvp MUTT/NUDIX FAMILY
PROTEIN


(Thermus
thermophilus)
PF00293
(NUDIX)
4 LEU A 169
ALA A  55
VAL A  49
PRO A  48
None
1.23A 3gv1B-2yvpA:
undetectable
3gv1B-2yvpA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Thermotoga
maritima)
PF01425
(Amidase)
4 LEU A 378
ALA A 248
VAL A 283
PRO A 250
None
1.21A 3gv1B-3al0A:
undetectable
3gv1B-3al0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN


(Bifidobacterium
longum)
PF02541
(Ppx-GppA)
4 LEU A  53
ALA A  94
VAL A 121
PRO A 119
None
1.16A 3gv1B-3cerA:
undetectable
3gv1B-3cerA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwv DNA GYRASE, B
SUBUNIT, TRUNCATED


(Myxococcus
xanthus)
PF00204
(DNA_gyraseB)
4 LEU A  33
ALA A 106
VAL A  14
PRO A  18
None
1.00A 3gv1B-3cwvA:
undetectable
3gv1B-3cwvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d79 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0734


(Pyrococcus
horikoshii)
PF01472
(PUA)
PF09183
(DUF1947)
4 LEU A 101
ALA A 136
VAL A 126
PRO A 134
None
0.80A 3gv1B-3d79A:
undetectable
3gv1B-3d79A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkw DNR PROTEIN

(Pseudomonas
aeruginosa)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
4 LEU A  56
ALA A 102
VAL A 103
PRO A 105
None
1.18A 3gv1B-3dkwA:
undetectable
3gv1B-3dkwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkw DNR PROTEIN

(Pseudomonas
aeruginosa)
PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2)
4 LEU A 108
ALA A 102
VAL A 103
PRO A 105
None
1.24A 3gv1B-3dkwA:
undetectable
3gv1B-3dkwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e23 UNCHARACTERIZED
PROTEIN RPA2492


(Rhodopseudomonas
palustris)
PF08241
(Methyltransf_11)
4 LEU A  62
ALA A  70
VAL A  89
PRO A  88
None
0.96A 3gv1B-3e23A:
undetectable
3gv1B-3e23A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE


(Bacteroides
vulgatus)
PF16392
(DUF5001)
4 LEU A 262
ALA A 189
VAL A 188
PRO A 196
None
0.97A 3gv1B-3e38A:
undetectable
3gv1B-3e38A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY


(Methanopyrus
kandleri)
PF00493
(MCM)
4 LEU A  46
ALA A  89
VAL A  92
PRO A  94
None
0.98A 3gv1B-3f8tA:
undetectable
3gv1B-3f8tA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B


(Escherichia
coli)
PF02518
(HATPase_c)
4 LEU A  35
ALA A 121
VAL A  19
PRO A  23
None
1.00A 3gv1B-3fv5A:
undetectable
3gv1B-3fv5A:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gv1 DISULFIDE
INTERCHANGE PROTEIN


(Neisseria
gonorrhoeae)
PF13098
(Thioredoxin_2)
4 LEU A 125
ALA A 141
VAL A 236
PRO A 238
None
0.11A 3gv1B-3gv1A:
29.9
3gv1B-3gv1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE


(Porphyromonas
gingivalis)
no annotation 4 LEU A 219
ALA A 204
VAL A 166
PRO A 168
None
1.20A 3gv1B-3ll7A:
undetectable
3gv1B-3ll7A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lps TOPOISOMERASE IV
SUBUNIT B


(Xanthomonas
oryzae)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A  79
ALA A 165
VAL A  63
PRO A  67
None
1.10A 3gv1B-3lpsA:
undetectable
3gv1B-3lpsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT BETA


(Desulfovibrio
gigas)
PF00037
(Fer4)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
4 LEU B 218
ALA B 227
VAL B 228
PRO B 225
None
1.24A 3gv1B-3or2B:
undetectable
3gv1B-3or2B:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE


(Staphylococcus
aureus)
PF08534
(Redoxin)
4 LEU A  13
ALA A 129
VAL A  51
PRO A  53
SO4  A 165 (-3.7A)
None
None
None
0.77A 3gv1B-3p7xA:
3.8
3gv1B-3p7xA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Streptococcus
pneumoniae)
PF06824
(Glyco_hydro_125)
4 LEU A 361
ALA A 343
VAL A 397
PRO A 400
None
1.16A 3gv1B-3qpfA:
undetectable
3gv1B-3qpfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt3 PUTATIVE
UNCHARACTERIZED
PROTEIN CPE0426


(Clostridium
perfringens)
PF06824
(Glyco_hydro_125)
4 LEU A 361
ALA A 343
VAL A 397
PRO A 400
None
1.11A 3gv1B-3qt3A:
undetectable
3gv1B-3qt3A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r77 PROBABLE
ISOCHORISMATASE


(Pseudomonas
fluorescens)
PF00857
(Isochorismatase)
4 LEU A 145
ALA A  74
VAL A  73
PRO A  72
None
1.24A 3gv1B-3r77A:
undetectable
3gv1B-3r77A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis)
PF00128
(Alpha-amylase)
4 LEU A 531
ALA A 502
VAL A 546
PRO A 542
None
1.21A 3gv1B-3ucqA:
undetectable
3gv1B-3ucqA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uif SULFONATE ABC
TRANSPORTER,
PERIPLASMIC
SULFONATE-BINDING
PROTEIN SSUA


(Methylobacillus
flagellatus)
PF09084
(NMT1)
4 LEU A 184
ALA A 145
VAL A 175
PRO A 177
None
None
None
SO4  A 501 (-4.1A)
1.20A 3gv1B-3uifA:
undetectable
3gv1B-3uifA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN


(Streptomyces
thermoviolaceus)
PF01547
(SBP_bac_1)
4 LEU A 172
ALA A 191
VAL A 193
PRO A 195
None
1.06A 3gv1B-3vxcA:
undetectable
3gv1B-3vxcA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa)
PF12697
(Abhydrolase_6)
4 LEU A 229
ALA A 213
VAL A 214
PRO A 211
None
1.24A 3gv1B-3w04A:
1.4
3gv1B-3w04A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zby P450 HEME-THIOLATE
PROTEIN


(Mycolicibacterium
smegmatis)
PF00067
(p450)
4 LEU A 116
ALA A 139
VAL A 140
PRO A 137
None
1.15A 3gv1B-3zbyA:
undetectable
3gv1B-3zbyA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A  45
ALA A 130
VAL A  26
PRO A  30
None
1.13A 3gv1B-3zkbA:
undetectable
3gv1B-3zkbA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0r PUTATIVE AMINO ACID
BINDING PROTEIN


(Streptococcus
mutans)
PF00497
(SBP_bac_3)
4 LEU A 220
ALA A  87
VAL A 192
PRO A  85
None
1.18A 3gv1B-4c0rA:
undetectable
3gv1B-4c0rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dut NUCLEOSIDE
DIPHOSPHATE KINASE


(Burkholderia
thailandensis)
PF00334
(NDK)
4 LEU A   7
ALA A  36
VAL A 138
PRO A 134
None
1.22A 3gv1B-4dutA:
undetectable
3gv1B-4dutA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
4 LEU A 401
ALA A 392
VAL A 288
PRO A 287
None
1.18A 3gv1B-4e4gA:
undetectable
3gv1B-4e4gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT


(Streptococcus
pneumoniae)
PF02518
(HATPase_c)
4 LEU A  44
ALA A 129
VAL A  25
PRO A  29
None
1.10A 3gv1B-4em7A:
undetectable
3gv1B-4em7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT


(Streptococcus
pneumoniae)
PF00497
(SBP_bac_3)
4 LEU A 256
ALA A 122
VAL A 228
PRO A 120
None
1.03A 3gv1B-4eq9A:
undetectable
3gv1B-4eq9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxw DNA GYRASE SUBUNIT B

(Enterococcus
faecalis)
PF02518
(HATPase_c)
4 LEU A  48
ALA A 134
VAL A  29
PRO A  33
None
1.12A 3gv1B-4hxwA:
undetectable
3gv1B-4hxwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B


(Francisella
tularensis)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A  34
ALA A 120
VAL A  18
PRO A  22
None
1.05A 3gv1B-4hymA:
undetectable
3gv1B-4hymA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT


(Enterococcus
faecalis)
PF02518
(HATPase_c)
4 LEU A  42
ALA A 127
VAL A  23
PRO A  27
None
1.20A 3gv1B-4hz5A:
undetectable
3gv1B-4hz5A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE


(Pseudomonas
savastanoi)
PF01593
(Amino_oxidase)
4 LEU A 182
ALA A 193
VAL A 173
PRO A 175
None
1.20A 3gv1B-4iv9A:
undetectable
3gv1B-4iv9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyp HYDROLASE,
ALPHA/BETA FOLD
FAMILY PROTEIN


(Arabidopsis
thaliana)
PF12697
(Abhydrolase_6)
4 LEU A 178
ALA A 161
VAL A 162
PRO A 159
None
1.22A 3gv1B-4jypA:
0.8
3gv1B-4jypA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Vibrio cholerae)
PF01135
(PCMT)
4 LEU A 158
ALA A 151
VAL A 172
PRO A 171
None
1.16A 3gv1B-4l7vA:
undetectable
3gv1B-4l7vA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o29 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrobaculum
aerophilum)
PF01135
(PCMT)
4 LEU A 159
ALA A 152
VAL A 173
PRO A 172
None
1.12A 3gv1B-4o29A:
undetectable
3gv1B-4o29A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5


(Homo sapiens)
PF03921
(ICAM_N)
4 LEU A 190
ALA A 156
VAL A 103
PRO A 102
None
1.10A 3gv1B-4oibA:
undetectable
3gv1B-4oibA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 LEU A 269
ALA A  21
VAL A 278
PRO A 447
None
1.00A 3gv1B-4oqjA:
undetectable
3gv1B-4oqjA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiu NITRONATE
MONOOXYGENASE FAMILY
PROTEIN


(Pseudomonas
aeruginosa)
PF03060
(NMO)
4 LEU A   9
ALA A 235
VAL A 214
PRO A 212
None
1.17A 3gv1B-4qiuA:
undetectable
3gv1B-4qiuA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9n LMO0547 PROTEIN

(Listeria
monocytogenes)
PF04198
(Sugar-bind)
4 LEU A 264
ALA A 205
VAL A 275
PRO A 273
None
1.00A 3gv1B-4r9nA:
undetectable
3gv1B-4r9nA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlt (3R)-HYDROXYACYL-ACP
DEHYDRATASE SUBUNIT
HADB


(Mycobacterium
tuberculosis)
PF01575
(MaoC_dehydratas)
4 LEU B 102
ALA B 100
VAL B  93
PRO B  92
None
1.11A 3gv1B-4rltB:
undetectable
3gv1B-4rltB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnu ASPARTOACYLASE

(Homo sapiens)
PF04952
(AstE_AspA)
4 LEU A  69
ALA A  57
VAL A  58
PRO A  55
None
1.14A 3gv1B-4tnuA:
undetectable
3gv1B-4tnuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4url DNA TOPOISOMERASE
IV, B SUBUNIT


(Staphylococcus
aureus)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A  42
ALA A 127
VAL A  23
PRO A  27
None
1.08A 3gv1B-4urlA:
undetectable
3gv1B-4urlA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT


(Staphylococcus
aureus)
PF02518
(HATPase_c)
4 LEU A  42
ALA A 127
VAL A  23
PRO A  27
None
1.14A 3gv1B-4urnA:
undetectable
3gv1B-4urnA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A


(Pseudomonas
aeruginosa)
PF06026
(Rib_5-P_isom_A)
4 LEU A  43
ALA A  53
VAL A  71
PRO A  70
None
1.13A 3gv1B-4x84A:
undetectable
3gv1B-4x84A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjc DEOXYCYTIDINE
TRIPHOSPHATE
DEAMINASE


(Bacillus
halodurans)
PF00692
(dUTPase)
4 LEU A  17
ALA A  93
VAL A 114
PRO A 116
None
None
TTP  A 201 ( 4.0A)
None
0.94A 3gv1B-4xjcA:
undetectable
3gv1B-4xjcA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ys8 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE


(Burkholderia
thailandensis)
PF01128
(IspD)
4 LEU A 211
ALA A 140
VAL A 139
PRO A 138
None
1.23A 3gv1B-4ys8A:
1.4
3gv1B-4ys8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zze SUGAR BINDING
PROTEIN OF ABC
TRANSPORTER SYSTEM


(Bifidobacterium
animalis)
PF01547
(SBP_bac_1)
4 LEU A 354
ALA A 163
VAL A 327
PRO A 161
None
0.80A 3gv1B-4zzeA:
undetectable
3gv1B-4zzeA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amw FRA A 2 ALLERGEN

(Fragaria x
ananassa)
PF00407
(Bet_v_1)
4 LEU A 147
ALA A  38
VAL A  39
PRO A  36
None
1.04A 3gv1B-5amwA:
undetectable
3gv1B-5amwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA


(Schizosaccharomyces
pombe)
PF00483
(NTP_transferase)
4 LEU E  65
ALA E 414
VAL E 432
PRO E  53
None
1.04A 3gv1B-5b04E:
undetectable
3gv1B-5b04E:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE


(Acinetobacter
baumannii)
PF00275
(EPSP_synthase)
4 LEU A 635
ALA A 628
VAL A 625
PRO A 621
None
1.13A 3gv1B-5bs5A:
undetectable
3gv1B-5bs5A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN


(Colletotrichum
graminicola)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 LEU A 340
ALA A 475
VAL A 474
PRO A 472
None
1.24A 3gv1B-5c92A:
undetectable
3gv1B-5c92A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078


(Thermobifida
fusca)
PF04261
(Dyp_perox)
4 LEU A 384
ALA A  76
VAL A 103
PRO A  33
None
1.11A 3gv1B-5fw4A:
undetectable
3gv1B-5fw4A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtq LUCIFERIN
REGENERATING ENZYME


(Photinus
pyralis)
PF08450
(SGL)
4 LEU A 131
ALA A 157
VAL A 136
PRO A 135
None
1.23A 3gv1B-5gtqA:
undetectable
3gv1B-5gtqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli)
PF01204
(Trehalase)
4 LEU A 224
ALA A 216
VAL A 203
PRO A 202
None
1.23A 3gv1B-5gw7A:
undetectable
3gv1B-5gw7A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2


(Mus musculus)
PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2)
4 LEU A2974
ALA A2948
VAL A2949
PRO A3059
None
1.03A 3gv1B-5ik8A:
undetectable
3gv1B-5ik8A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B


(Streptococcus
pneumoniae)
PF00204
(DNA_gyraseB)
PF02518
(HATPase_c)
4 LEU A  44
ALA A 129
VAL A  25
PRO A  29
None
1.14A 3gv1B-5j5pA:
undetectable
3gv1B-5j5pA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA


(Methylobacillus
flagellatus)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
4 LEU C 304
ALA C 348
VAL C 327
PRO C 325
None
1.22A 3gv1B-5ks8C:
undetectable
3gv1B-5ks8C:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC


(Vibrio cholerae)
PF05943
(VipB)
4 LEU A 206
ALA A 240
VAL A 193
PRO A 195
None
1.08A 3gv1B-5myuA:
undetectable
3gv1B-5myuA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4


(Homo sapiens)
no annotation 4 LEU A 237
ALA A 315
VAL A 252
PRO A 254
None
1.02A 3gv1B-5nqaA:
undetectable
3gv1B-5nqaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio)
no annotation 4 LEU A 453
ALA A 365
VAL A 305
PRO A 304
None
1.15A 3gv1B-5yh0A:
undetectable
3gv1B-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C


(Homo sapiens)
no annotation 4 LEU C 477
ALA C 389
VAL C 329
PRO C 328
None
1.08A 3gv1B-5yh3C:
undetectable
3gv1B-5yh3C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN


(Bifidobacterium
longum)
no annotation 4 LEU A 541
ALA A 513
VAL A 408
PRO A 410
None
1.14A 3gv1B-5z9sA:
undetectable
3gv1B-5z9sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ams BETA SLIDING CLAMP

(Pseudomonas
aeruginosa)
no annotation 4 LEU A 284
ALA A 348
VAL A 362
PRO A 364
None
1.23A 3gv1B-6amsA:
undetectable
3gv1B-6amsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2


(Petunia x
hybrida)
no annotation 4 LEU A 178
ALA A 162
VAL A 163
PRO A 160
None
1.21A 3gv1B-6ap6A:
1.2
3gv1B-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE


(Rhodothermus
marinus)
no annotation 4 LEU B 635
ALA B 607
VAL B 646
PRO B 645
None
1.20A 3gv1B-6f0kB:
undetectable
3gv1B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gk6 -

(-)
no annotation 4 LEU A 129
ALA A 152
VAL A 153
PRO A 150
None
1.14A 3gv1B-6gk6A:
undetectable
3gv1B-6gk6A:
undetectable