SIMILAR PATTERNS OF AMINO ACIDS FOR 3GV1_B_BEZB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 LEU A 268
ALA A 312
PRO A 188
PRO A 181
 None
 1.12A 3gv1A-1b1yA:
0.0
3gv1B-1b1yA:
0.0		 3gv1A-1b1yA:
15.90
3gv1B-1b1yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 307
ALA A  32
PRO A  30
PRO A  29
 None
 1.29A 3gv1A-1bt2A:
undetectable
3gv1B-1bt2A:
0.0		 3gv1A-1bt2A:
15.65
3gv1B-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 LEU A 270
ALA A 314
PRO A 190
PRO A 183
 None
 1.10A 3gv1A-1btcA:
0.0
3gv1B-1btcA:
undetectable		 3gv1A-1btcA:
13.09
3gv1B-1btcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A  12
ALA A  58
PRO A 281
HIS A 272
 None
 1.07A 3gv1A-1eblA:
0.0
3gv1B-1eblA:
0.0		 3gv1A-1eblA:
19.18
3gv1B-1eblA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA B 486
PRO B 488
PRO B 646
HIS B 747
 None
 1.23A 3gv1A-1ffvB:
0.0
3gv1B-1ffvB:
0.0		 3gv1A-1ffvB:
12.76
3gv1B-1ffvB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 LEU A 147
ALA A 170
PRO A 160
HIS A 151
 None
 1.28A 3gv1A-1fp9A:
0.0
3gv1B-1fp9A:
0.0		 3gv1A-1fp9A:
12.75
3gv1B-1fp9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 290
LYS A 263
ALA A 261
PRO A 266
 None
 1.35A 3gv1A-1j33A:
0.0
3gv1B-1j33A:
0.0		 3gv1A-1j33A:
17.26
3gv1B-1j33A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kw2 VITAMIN D-BINDING
PROTEIN

(Homo sapiens) 		PF00273
(Serum_albumin)
PF09164
(VitD-bind_III) 		4 LEU A 212
LYS A 276
PRO A 279
HIS A 208
 None
 1.07A 3gv1A-1kw2A:
0.0
3gv1B-1kw2A:
0.0		 3gv1A-1kw2A:
15.65
3gv1B-1kw2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C

(Enterovirus C) 		PF00548
(Peptidase_C3) 		4 LEU A 127
ALA A 172
PRO A  38
HIS A  40
 None
 1.34A 3gv1A-1l1nA:
0.0
3gv1B-1l1nA:
0.0		 3gv1A-1l1nA:
22.10
3gv1B-1l1nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU D 257
ALA D 265
PRO D 267
PRO D 277
 None
 1.27A 3gv1A-1oy3D:
undetectable
3gv1B-1oy3D:
undetectable		 3gv1A-1oy3D:
18.25
3gv1B-1oy3D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		4 LEU A 298
ALA A 302
PRO A 305
HIS A 362
 None
 1.15A 3gv1A-1p1mA:
undetectable
3gv1B-1p1mA:
undetectable		 3gv1A-1p1mA:
14.04
3gv1B-1p1mA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 LEU P 146
ALA P 222
PRO P 124
PRO P 125
 None
 1.31A 3gv1A-1r6zP:
undetectable
3gv1B-1r6zP:
undetectable		 3gv1A-1r6zP:
14.99
3gv1B-1r6zP:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 LEU A 261
ALA A 308
PRO A 176
PRO A 169
 None
 1.00A 3gv1A-1venA:
undetectable
3gv1B-1venA:
undetectable		 3gv1A-1venA:
14.09
3gv1B-1venA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.23A 3gv1A-1y4cA:
undetectable
3gv1B-1y4cA:
undetectable		 3gv1A-1y4cA:
13.56
3gv1B-1y4cA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 LYS A  17
ALA A  15
PRO A  19
PRO A  36
 None
 1.15A 3gv1A-1yiqA:
undetectable
3gv1B-1yiqA:
undetectable		 3gv1A-1yiqA:
12.59
3gv1B-1yiqA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 LEU A 104
ALA A 150
PRO A 157
PRO A 128
 None
 0.95A 3gv1A-2cb1A:
undetectable
3gv1B-2cb1A:
undetectable		 3gv1A-2cb1A:
14.49
3gv1B-2cb1A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d28 TYPE II SECRETION
ATPASE XPSE

(Xanthomonas
campestris) 		PF05157
(T2SSE_N) 		4 LEU C  40
ALA C   6
PRO C 113
HIS C  54
 None
 1.04A 3gv1A-2d28C:
undetectable
3gv1B-2d28C:
undetectable		 3gv1A-2d28C:
18.67
3gv1B-2d28C:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 LEU A   9
ALA A  76
PRO A  74
PRO A  43
 None
 1.35A 3gv1A-2fjkA:
undetectable
3gv1B-2fjkA:
undetectable		 3gv1A-2fjkA:
17.38
3gv1B-2fjkA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 LEU A 548
LYS A 536
ALA A 534
PRO A 539
 None
 1.14A 3gv1A-2gw1A:
undetectable
3gv1B-2gw1A:
undetectable		 3gv1A-2gw1A:
14.01
3gv1B-2gw1A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrx DNA-BINDING PROTEIN
STPA

(Escherichia
coli) 		PF00816
(Histone_HNS) 		4 LEU A  40
ALA A  33
PRO A  29
PRO A  27
 None
 1.21A 3gv1A-2lrxA:
undetectable
3gv1B-2lrxA:
undetectable		 3gv1A-2lrxA:
15.79
3gv1B-2lrxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mra DE NOVO DESIGNED
PROTEIN OR459

(synthetic
construct) 		no annotation 4 LEU A 110
LYS A  91
ALA A  85
HIS A 112
 None
 1.36A 3gv1A-2mraA:
undetectable
3gv1B-2mraA:
undetectable		 3gv1A-2mraA:
23.65
3gv1B-2mraA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 LEU A 152
ALA A 243
PRO A 213
PRO A 214
 None
None
AHB  A7002 (-4.2A)
None
 1.28A 3gv1A-2og7A:
undetectable
3gv1B-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1B-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LEU A 241
ALA A 196
PRO A   4
PRO A   5
 None
 1.23A 3gv1A-2pcqA:
undetectable
3gv1B-2pcqA:
undetectable		 3gv1A-2pcqA:
18.12
3gv1B-2pcqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LYS A 658
ALA A 656
PRO A 666
HIS A 669
 None
 1.34A 3gv1A-2r6fA:
undetectable
3gv1B-2r6fA:
undetectable		 3gv1A-2r6fA:
9.03
3gv1B-2r6fA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 LEU A  21
ALA A  36
PRO A  55
HIS A  25
 None
GOL  A 601 ( 4.1A)
None
None
 1.35A 3gv1A-2r8rA:
undetectable
3gv1B-2r8rA:
undetectable		 3gv1A-2r8rA:
17.62
3gv1B-2r8rA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 LEU A 132
ALA A 128
PRO A  66
HIS A 106
 None
 1.24A 3gv1A-3atyA:
undetectable
3gv1B-3atyA:
undetectable		 3gv1A-3atyA:
19.10
3gv1B-3atyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clo TRANSCRIPTIONAL
REGULATOR

(Bacteroides
thetaiotaomicron) 		PF00196
(GerE) 		4 LEU A 256
ALA A 250
PRO A  92
HIS A 193
 None
 1.18A 3gv1A-3cloA:
undetectable
3gv1B-3cloA:
undetectable		 3gv1A-3cloA:
18.32
3gv1B-3cloA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.27A 3gv1A-3csgA:
undetectable
3gv1B-3csgA:
undetectable		 3gv1A-3csgA:
13.67
3gv1B-3csgA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.31A 3gv1A-3dm0A:
undetectable
3gv1B-3dm0A:
undetectable		 3gv1A-3dm0A:
11.01
3gv1B-3dm0A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 LEU A  66
LYS A  30
ALA A  36
PRO A  44
 None
 1.16A 3gv1A-3fijA:
undetectable
3gv1B-3fijA:
undetectable		 3gv1A-3fijA:
22.99
3gv1B-3fijA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 LEU A 125
LYS A 139
ALA A 141
PRO A 238
 None
 0.00A 3gv1A-3gv1A:
32.0
3gv1B-3gv1A:
29.9		 3gv1A-3gv1A:
100.00
3gv1B-3gv1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.26A 3gv1A-3h4zA:
undetectable
3gv1B-3h4zA:
undetectable		 3gv1A-3h4zA:
14.78
3gv1B-3h4zA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME

(Leishmania
major) 		PF08694
(UFC1) 		4 LEU A  15
ALA A  36
PRO A  13
HIS A 135
 None
 1.23A 3gv1A-3kpaA:
undetectable
3gv1B-3kpaA:
undetectable		 3gv1A-3kpaA:
18.93
3gv1B-3kpaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 LEU A 286
ALA A 228
PRO A 305
PRO A 306
 None
 1.33A 3gv1A-3lkdA:
undetectable
3gv1B-3lkdA:
undetectable		 3gv1A-3lkdA:
15.31
3gv1B-3lkdA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7g TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13404
(HTH_AsnC-type) 		4 LEU A 142
ALA A 167
PRO A 163
PRO A 156
 None
 1.18A 3gv1A-3m7gA:
undetectable
3gv1B-3m7gA:
undetectable		 3gv1A-3m7gA:
16.91
3gv1B-3m7gA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkb HEMOGLOBIN SUBUNIT
ALPHA

(Isurus
oxyrinchus) 		PF00042
(Globin) 		4 LEU A  83
LYS A  61
ALA A  65
HIS A  87
 HEM  A 141 ( 4.8A)
HEM  A 141 ( 4.7A)
HEM  A 141 (-3.5A)
HEM  A 141 (-3.3A)
 1.30A 3gv1A-3mkbA:
undetectable
3gv1B-3mkbA:
undetectable		 3gv1A-3mkbA:
21.71
3gv1B-3mkbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 LEU A 885
ALA A 961
PRO A 863
PRO A 864
 None
 1.31A 3gv1A-3mp6A:
undetectable
3gv1B-3mp6A:
undetectable		 3gv1A-3mp6A:
13.60
3gv1B-3mp6A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-3mq9A:
undetectable
3gv1B-3mq9A:
undetectable		 3gv1A-3mq9A:
14.44
3gv1B-3mq9A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr0 SENSORY BOX
HISTIDINE
KINASE/RESPONSE
REGULATOR

(Burkholderia
thailandensis) 		PF08447
(PAS_3) 		4 LEU A  69
ALA A 101
PRO A 109
PRO A  24
 PG5  A 143 ( 4.9A)
None
None
None
 1.32A 3gv1A-3mr0A:
undetectable
3gv1B-3mr0A:
undetectable		 3gv1A-3mr0A:
21.02
3gv1B-3mr0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.30A 3gv1A-3oaiA:
undetectable
3gv1B-3oaiA:
undetectable		 3gv1A-3oaiA:
14.00
3gv1B-3oaiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.33A 3gv1A-3osrA:
undetectable
3gv1B-3osrA:
undetectable		 3gv1A-3osrA:
11.45
3gv1B-3osrA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 LEU A 128
ALA A 154
PRO A  95
HIS A 131
 None
 1.13A 3gv1A-3ow2A:
undetectable
3gv1B-3ow2A:
undetectable		 3gv1A-3ow2A:
16.94
3gv1B-3ow2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A  96
LYS A 126
ALA A  19
PRO A  74
 None
 1.21A 3gv1A-3pv4A:
undetectable
3gv1B-3pv4A:
undetectable		 3gv1A-3pv4A:
16.67
3gv1B-3pv4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 LEU A 313
ALA A 366
PRO A 413
PRO A 374
 None
 0.95A 3gv1A-3qp9A:
undetectable
3gv1B-3qp9A:
undetectable		 3gv1A-3qp9A:
12.48
3gv1B-3qp9A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 LYS A 226
ALA A 222
PRO A 229
PRO A 250
 None
EDO  A 910 (-3.7A)
EDO  A 907 (-4.4A)
None
 1.24A 3gv1A-3s1sA:
undetectable
3gv1B-3s1sA:
undetectable		 3gv1A-3s1sA:
9.91
3gv1B-3s1sA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A  91
ALA A  32
PRO A  53
HIS A  55
 None
 1.06A 3gv1A-3s2uA:
undetectable
3gv1B-3s2uA:
1.7		 3gv1A-3s2uA:
16.71
3gv1B-3s2uA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.34A 3gv1A-3waiA:
undetectable
3gv1B-3waiA:
undetectable		 3gv1A-3waiA:
11.02
3gv1B-3waiA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 LEU A 475
LYS A 463
ALA A 461
PRO A 466
 None
 1.04A 3gv1A-3zgqA:
undetectable
3gv1B-3zgqA:
undetectable		 3gv1A-3zgqA:
16.55
3gv1B-3zgqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P
SAR1P

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00025
(Arf) 		4 LEU A 371
ALA A 607
PRO A 603
HIS B  56
 None
 1.19A 3gv1A-4bziA:
undetectable
3gv1B-4bziA:
undetectable		 3gv1A-4bziA:
11.56
3gv1B-4bziA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 LEU A 885
ALA A 857
PRO A 851
HIS A 848
 None
None
None
CD  A1990 (-3.3A)
 0.75A 3gv1A-4cvuA:
undetectable
3gv1B-4cvuA:
undetectable		 3gv1A-4cvuA:
9.65
3gv1B-4cvuA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.33A 3gv1A-4dxbA:
undetectable
3gv1B-4dxbA:
undetectable		 3gv1A-4dxbA:
12.40
3gv1B-4dxbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.33A 3gv1A-4edqA:
undetectable
3gv1B-4edqA:
undetectable		 3gv1A-4edqA:
13.01
3gv1B-4edqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.30A 3gv1A-4exkA:
undetectable
3gv1B-4exkA:
undetectable		 3gv1A-4exkA:
13.14
3gv1B-4exkA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 LEU A  59
ALA A  83
PRO A  57
HIS A  31
 None
 1.29A 3gv1A-4g8dA:
1.5
3gv1B-4g8dA:
undetectable		 3gv1A-4g8dA:
22.58
3gv1B-4g8dA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 LEU A-223
ALA A-147
PRO A-245
PRO A-244
 None
 1.32A 3gv1A-4h1gA:
undetectable
3gv1B-4h1gA:
undetectable		 3gv1A-4h1gA:
11.42
3gv1B-4h1gA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.27A 3gv1A-4ikmA:
undetectable
3gv1B-4ikmA:
undetectable		 3gv1A-4ikmA:
16.20
3gv1B-4ikmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.32A 3gv1A-4irlA:
undetectable
3gv1B-4irlA:
undetectable		 3gv1A-4irlA:
15.97
3gv1B-4irlA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 LYS A 212
ALA A 214
PRO A 138
HIS A 202
 None
 1.18A 3gv1A-4jclA:
undetectable
3gv1B-4jclA:
undetectable		 3gv1A-4jclA:
10.77
3gv1B-4jclA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.31A 3gv1A-4kegA:
undetectable
3gv1B-4kegA:
undetectable		 3gv1A-4kegA:
13.02
3gv1B-4kegA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.21A 3gv1A-4logA:
undetectable
3gv1B-4logA:
undetectable		 3gv1A-4logA:
12.63
3gv1B-4logA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 LEU A 473
ALA A 391
PRO A 464
PRO A 402
 None
 1.35A 3gv1A-4mh1A:
undetectable
3gv1B-4mh1A:
undetectable		 3gv1A-4mh1A:
12.99
3gv1B-4mh1A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.33A 3gv1A-4my2A:
undetectable
3gv1B-4my2A:
undetectable		 3gv1A-4my2A:
14.01
3gv1B-4my2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A  12
ALA A  58
PRO A 280
HIS A 271
 None
 1.22A 3gv1A-4nhdA:
undetectable
3gv1B-4nhdA:
undetectable		 3gv1A-4nhdA:
15.89
3gv1B-4nhdA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 LEU A-223
ALA A-147
PRO A-245
PRO A-244
 None
 1.31A 3gv1A-4ozqA:
undetectable
3gv1B-4ozqA:
undetectable		 3gv1A-4ozqA:
11.89
3gv1B-4ozqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 696
ALA A  99
PRO A  39
HIS A 693
 None
 1.19A 3gv1A-4pd3A:
undetectable
3gv1B-4pd3A:
undetectable		 3gv1A-4pd3A:
9.11
3gv1B-4pd3A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmd ENVOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 LEU A1858
ALA A1996
PRO A2012
PRO A1985
 None
 1.33A 3gv1A-4qmdA:
undetectable
3gv1B-4qmdA:
undetectable		 3gv1A-4qmdA:
20.73
3gv1B-4qmdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.28A 3gv1A-4rwfA:
undetectable
3gv1B-4rwfA:
undetectable		 3gv1A-4rwfA:
12.67
3gv1B-4rwfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s28 PHOSPHOMETHYLPYRIMID
INE SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01964
(ThiC_Rad_SAM) 		4 LEU A 544
LYS A  94
PRO A  93
PRO A 548
 None
 1.35A 3gv1A-4s28A:
undetectable
3gv1B-4s28A:
undetectable		 3gv1A-4s28A:
13.41
3gv1B-4s28A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 LEU A 842
ALA A 878
PRO A 876
PRO A 903
 None
 1.33A 3gv1A-4ts6A:
undetectable
3gv1B-4ts6A:
undetectable		 3gv1A-4ts6A:
23.72
3gv1B-4ts6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.30A 3gv1A-4tsmA:
undetectable
3gv1B-4tsmA:
undetectable		 3gv1A-4tsmA:
15.58
3gv1B-4tsmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 LEU A  47
ALA A  60
PRO A  58
HIS A 155
 None
 0.89A 3gv1A-4uqmA:
undetectable
3gv1B-4uqmA:
undetectable		 3gv1A-4uqmA:
17.67
3gv1B-4uqmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 171
ALA A 247
PRO A 149
PRO A 150
 None
 1.24A 3gv1A-4wrnA:
undetectable
3gv1B-4wrnA:
undetectable		 3gv1A-4wrnA:
10.07
3gv1B-4wrnA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		4 LEU A  22
ALA A  34
PRO A  30
HIS A  25
 None
 1.31A 3gv1A-4wx6A:
undetectable
3gv1B-4wx6A:
undetectable		 3gv1A-4wx6A:
19.80
3gv1B-4wx6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		4 LEU A 306
LYS A 252
ALA A 275
PRO A 304
 None
 1.25A 3gv1A-4x6kA:
undetectable
3gv1B-4x6kA:
undetectable		 3gv1A-4x6kA:
14.55
3gv1B-4x6kA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.32A 3gv1A-4xa2A:
undetectable
3gv1B-4xa2A:
undetectable		 3gv1A-4xa2A:
15.66
3gv1B-4xa2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS
INSCUTEABLE

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 LEU B 230
ALA L 320
PRO L 323
HIS B 172
 None
 0.99A 3gv1A-5a7dB:
undetectable
3gv1B-5a7dB:
undetectable		 3gv1A-5a7dB:
18.21
3gv1B-5a7dB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-5azaA:
undetectable
3gv1B-5azaA:
undetectable		 3gv1A-5azaA:
10.89
3gv1B-5azaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-5cfvA:
undetectable
3gv1B-5cfvA:
undetectable		 3gv1A-5cfvA:
15.96
3gv1B-5cfvA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		4 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.31A 3gv1A-5gxvA:
undetectable
3gv1B-5gxvA:
undetectable		 3gv1A-5gxvA:
14.10
3gv1B-5gxvA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.33A 3gv1A-5h7nA:
undetectable
3gv1B-5h7nA:
undetectable		 3gv1A-5h7nA:
17.15
3gv1B-5h7nA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd9 ENCAPSIDATION
PROTEIN

(Bacillus virus
phi29) 		PF05894
(Podovirus_Gp16) 		4 LEU A 156
LYS A  35
ALA A  33
PRO A  38
 None
 1.29A 3gv1A-5hd9A:
undetectable
3gv1B-5hd9A:
undetectable		 3gv1A-5hd9A:
21.05
3gv1B-5hd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 LEU A 142
ALA A 167
PRO A 163
PRO A 156
 None
 1.24A 3gv1A-5hm5A:
undetectable
3gv1B-5hm5A:
undetectable		 3gv1A-5hm5A:
9.48
3gv1B-5hm5A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.30A 3gv1A-5hz7A:
undetectable
3gv1B-5hz7A:
undetectable		 3gv1A-5hz7A:
15.13
3gv1B-5hz7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 514
ALA A 590
PRO A 492
PRO A 493
 None
 1.27A 3gv1A-5hzvA:
undetectable
3gv1B-5hzvA:
undetectable		 3gv1A-5hzvA:
13.26
3gv1B-5hzvA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 LEU A 202
ALA A 278
PRO A 180
PRO A 181
 None
 1.35A 3gv1A-5hzwA:
undetectable
3gv1B-5hzwA:
undetectable		 3gv1A-5hzwA:
11.00
3gv1B-5hzwA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 LEU A3814
ALA A3890
PRO A3792
PRO A3793
 None
 1.26A 3gv1A-5ii5A:
undetectable
3gv1B-5ii5A:
undetectable		 3gv1A-5ii5A:
13.77
3gv1B-5ii5A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A1223
PRO A 125
PRO A 126
 None
 1.34A 3gv1A-5k94A:
undetectable
3gv1B-5k94A:
undetectable		 3gv1A-5k94A:
12.40
3gv1B-5k94A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 ALA A 363
PRO A 366
PRO A 341
HIS A 301
 None
 1.26A 3gv1A-5ltaA:
undetectable
3gv1B-5ltaA:
undetectable		 3gv1A-5ltaA:
10.36
3gv1B-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n11 HEMAGGLUTININ-ESTERA
SE

(Betacoronavirus
1) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 LEU A 193
ALA A 273
PRO A 202
PRO A 270
 None
 1.35A 3gv1A-5n11A:
undetectable
3gv1B-5n11A:
undetectable		 3gv1A-5n11A:
15.93
3gv1B-5n11A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.25A 3gv1A-5osqA:
undetectable
3gv1B-5osqA:
undetectable		 3gv1A-5osqA:
16.63
3gv1B-5osqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-5tj2A:
undetectable
3gv1B-5tj2A:
undetectable		 3gv1A-5tj2A:
12.84
3gv1B-5tj2A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 LEU A 153
ALA A 229
PRO A 131
PRO A 132
 None
 1.30A 3gv1A-5ttdA:
undetectable
3gv1B-5ttdA:
undetectable		 3gv1A-5ttdA:
12.83
3gv1B-5ttdA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.36A 3gv1A-5vawA:
undetectable
3gv1B-5vawA:
undetectable		 3gv1A-5vawA:
undetectable
3gv1B-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 4 LEU A 132
LYS A  72
ALA A  76
HIS A 141
 None
 1.26A 3gv1A-5wnmA:
undetectable
3gv1B-5wnmA:
undetectable		 3gv1A-5wnmA:
undetectable
3gv1B-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TWO-COMPONEN
T SYSTEM SENSOR
KINASE

(Escherichia
coli;
Serratia
marcescens) 		no annotation 4 LEU A 149
ALA A 225
PRO A 127
PRO A 128
 None
 1.34A 3gv1A-5wvmA:
undetectable
3gv1B-5wvmA:
undetectable		 3gv1A-5wvmA:
undetectable
3gv1B-5wvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 LEU A 281
ALA A 563
PRO A 590
HIS A 301
 None
 1.24A 3gv1A-5x3jA:
undetectable
3gv1B-5x3jA:
undetectable		 3gv1A-5x3jA:
undetectable
3gv1B-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 LEU A 257
ALA A 242
PRO A 255
HIS A 227
 None
 1.33A 3gv1A-5xpgA:
undetectable
3gv1B-5xpgA:
undetectable		 3gv1A-5xpgA:
undetectable
3gv1B-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.29A 3gv1A-6apxA:
undetectable
3gv1B-6apxA:
undetectable		 3gv1A-6apxA:
16.35
3gv1B-6apxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1 156
LYS 1 260
ALA 1 262
HIS 1 226
 None
 1.21A 3gv1A-6c261:
undetectable
3gv1B-6c261:
undetectable		 3gv1A-6c261:
undetectable
3gv1B-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 LEU A 296
ALA A 332
PRO A 237
PRO A 150
 None
 1.19A 3gv1A-6f8yA:
undetectable
3gv1B-6f8yA:
undetectable		 3gv1A-6f8yA:
undetectable
3gv1B-6f8yA:
undetectable