SIMILAR PATTERNS OF AMINO ACIDS FOR 3GV1_A_BEZA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		4 PRO A 181
LEU A 268
ALA A 312
PRO A 188
 None
 1.07A 3gv1A-1b1yA:
0.0
3gv1C-1b1yA:
0.0		 3gv1A-1b1yA:
15.90
3gv1C-1b1yA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt2 PROTEIN (CATECHOL
OXIDASE)

(Ipomoea batatas) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 PRO A  29
LEU A 307
ALA A  32
PRO A  30
 None
 1.32A 3gv1A-1bt2A:
undetectable
3gv1C-1bt2A:
undetectable		 3gv1A-1bt2A:
15.65
3gv1C-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btc BETA-AMYLASE

(Glycine max) 		PF01373
(Glyco_hydro_14) 		4 PRO A 183
LEU A 270
ALA A 314
PRO A 190
 None
 1.06A 3gv1A-1btcA:
0.0
3gv1C-1btcA:
0.0		 3gv1A-1btcA:
13.09
3gv1C-1btcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 HIS A 272
LEU A  12
ALA A  58
PRO A 281
 None
 1.10A 3gv1A-1eblA:
0.0
3gv1C-1eblA:
0.0		 3gv1A-1eblA:
19.18
3gv1C-1eblA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PRO B 646
HIS B 747
ALA B 486
PRO B 488
 None
 1.19A 3gv1A-1ffvB:
0.0
3gv1C-1ffvB:
0.0		 3gv1A-1ffvB:
12.76
3gv1C-1ffvB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		4 PRO A 160
HIS A 151
LEU A 147
ALA A 170
 None
 1.22A 3gv1A-1fp9A:
undetectable
3gv1C-1fp9A:
undetectable		 3gv1A-1fp9A:
12.75
3gv1C-1fp9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iok CHAPERONIN 60

(Paracoccus
denitrificans) 		PF00118
(Cpn60_TCP1) 		4 HIS A 223
LEU A 227
LYS A 277
ALA A 275
 None
 1.26A 3gv1A-1iokA:
0.0
3gv1C-1iokA:
0.0		 3gv1A-1iokA:
13.11
3gv1C-1iokA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kw2 VITAMIN D-BINDING
PROTEIN

(Homo sapiens) 		PF00273
(Serum_albumin)
PF09164
(VitD-bind_III) 		4 HIS A 208
LEU A 212
LYS A 276
PRO A 279
 None
 1.05A 3gv1A-1kw2A:
0.0
3gv1C-1kw2A:
undetectable		 3gv1A-1kw2A:
15.65
3gv1C-1kw2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1n GENOME POLYPROTEIN:
PICORNAIN 3C

(Enterovirus C) 		PF00548
(Peptidase_C3) 		4 PRO A  38
HIS A  40
LEU A 127
ALA A 172
 None
 1.32A 3gv1A-1l1nA:
0.0
3gv1C-1l1nA:
0.0		 3gv1A-1l1nA:
22.10
3gv1C-1l1nA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PRO D 277
LEU D 257
ALA D 265
PRO D 267
 None
 1.33A 3gv1A-1oy3D:
undetectable
3gv1C-1oy3D:
undetectable		 3gv1A-1oy3D:
18.25
3gv1C-1oy3D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6z CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND ARGONAUTE 2

(Escherichia
coli;
Drosophila
melanogaster) 		no annotation 4 PRO P 125
LEU P 146
ALA P 222
PRO P 124
 None
 1.32A 3gv1A-1r6zP:
undetectable
3gv1C-1r6zP:
undetectable		 3gv1A-1r6zP:
14.99
3gv1C-1r6zP:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 PRO A 169
LEU A 261
ALA A 308
PRO A 176
 None
 0.96A 3gv1A-1venA:
undetectable
3gv1C-1venA:
undetectable		 3gv1A-1venA:
14.09
3gv1C-1venA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 HIS A 506
LEU A 423
ALA A 421
PRO A  60
 None
 1.19A 3gv1A-1w1kA:
undetectable
3gv1C-1w1kA:
undetectable		 3gv1A-1w1kA:
12.81
3gv1C-1w1kA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.25A 3gv1A-1y4cA:
undetectable
3gv1C-1y4cA:
undetectable		 3gv1A-1y4cA:
13.56
3gv1C-1y4cA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 128
LEU A 104
ALA A 150
PRO A 157
 None
 0.97A 3gv1A-2cb1A:
undetectable
3gv1C-2cb1A:
undetectable		 3gv1A-2cb1A:
14.49
3gv1C-2cb1A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d28 TYPE II SECRETION
ATPASE XPSE

(Xanthomonas
campestris) 		PF05157
(T2SSE_N) 		4 PRO C 113
HIS C  54
LEU C  40
ALA C   6
 None
 0.98A 3gv1A-2d28C:
undetectable
3gv1C-2d28C:
undetectable		 3gv1A-2d28C:
18.67
3gv1C-2d28C:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 PRO A  43
LEU A   9
ALA A  76
PRO A  74
 None
 1.34A 3gv1A-2fjkA:
undetectable
3gv1C-2fjkA:
undetectable		 3gv1A-2fjkA:
17.38
3gv1C-2fjkA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 LEU A 548
LYS A 536
ALA A 534
PRO A 539
 None
 1.10A 3gv1A-2gw1A:
undetectable
3gv1C-2gw1A:
undetectable		 3gv1A-2gw1A:
14.01
3gv1C-2gw1A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 HIS A1877
LEU A1881
ALA A1937
PRO A1650
 None
 1.33A 3gv1A-2ix8A:
undetectable
3gv1C-2ix8A:
undetectable		 3gv1A-2ix8A:
9.78
3gv1C-2ix8A:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrx DNA-BINDING PROTEIN
STPA

(Escherichia
coli) 		PF00816
(Histone_HNS) 		4 PRO A  27
LEU A  40
ALA A  33
PRO A  29
 None
 1.24A 3gv1A-2lrxA:
undetectable
3gv1C-2lrxA:
undetectable		 3gv1A-2lrxA:
15.79
3gv1C-2lrxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2npr MEROZOITE SURFACE
PROTEIN 1

(Plasmodium
vivax) 		PF12946
(EGF_MSP1_1)
PF12947
(EGF_3) 		4 LEU A  33
LYS A  74
ALA A  58
PRO A  82
 None
 1.26A 3gv1A-2nprA:
undetectable
3gv1C-2nprA:
undetectable		 3gv1A-2nprA:
21.23
3gv1C-2nprA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og7 ASPARAGINE OXYGENASE

(Streptomyces
coelicolor) 		PF02668
(TauD) 		4 PRO A 214
LEU A 152
ALA A 243
PRO A 213
 None
None
None
AHB  A7002 (-4.2A)
 1.25A 3gv1A-2og7A:
undetectable
3gv1C-2og7A:
undetectable		 3gv1A-2og7A:
17.09
3gv1C-2og7A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ovl PUTATIVE RACEMASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 PRO A 271
LEU A 309
ALA A 286
PRO A 269
 None
 1.22A 3gv1A-2ovlA:
undetectable
3gv1C-2ovlA:
undetectable		 3gv1A-2ovlA:
18.55
3gv1C-2ovlA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 PRO A   5
LEU A 241
ALA A 196
PRO A   4
 None
 1.20A 3gv1A-2pcqA:
undetectable
3gv1C-2pcqA:
undetectable		 3gv1A-2pcqA:
18.12
3gv1C-2pcqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpv UNCHARACTERIZED
PROTEIN ATU1531

(Agrobacterium
fabrum) 		no annotation 4 HIS A  73
LEU A  87
ALA A  24
PRO A  27
 None
 1.13A 3gv1A-2qpvA:
undetectable
3gv1C-2qpvA:
undetectable		 3gv1A-2qpvA:
21.89
3gv1C-2qpvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		4 HIS A  25
LEU A  21
ALA A  36
PRO A  55
 None
None
GOL  A 601 ( 4.1A)
None
 1.32A 3gv1A-2r8rA:
undetectable
3gv1C-2r8rA:
undetectable		 3gv1A-2r8rA:
17.62
3gv1C-2r8rA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfd LEUCYL-TRNA
SYNTHETASE,
CYTOPLASMIC

(Homo sapiens) 		PF00133
(tRNA-synt_1) 		4 PRO A 296
LEU A 366
LYS A 497
ALA A 504
 None
 1.33A 3gv1A-2wfdA:
undetectable
3gv1C-2wfdA:
undetectable		 3gv1A-2wfdA:
20.85
3gv1C-2wfdA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 PRO A  59
HIS A  14
LEU A  18
ALA A  55
 None
 1.21A 3gv1A-2yzmA:
undetectable
3gv1C-2yzmA:
undetectable		 3gv1A-2yzmA:
17.41
3gv1C-2yzmA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE

(Trypanosoma
cruzi) 		PF00724
(Oxidored_FMN) 		4 HIS A 106
LEU A 132
ALA A 128
PRO A  66
 None
 1.21A 3gv1A-3atyA:
undetectable
3gv1C-3atyA:
undetectable		 3gv1A-3atyA:
19.10
3gv1C-3atyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clo TRANSCRIPTIONAL
REGULATOR

(Bacteroides
thetaiotaomicron) 		PF00196
(GerE) 		4 HIS A 193
LEU A 256
ALA A 250
PRO A  92
 None
 1.17A 3gv1A-3cloA:
undetectable
3gv1C-3cloA:
undetectable		 3gv1A-3cloA:
18.32
3gv1C-3cloA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.29A 3gv1A-3csgA:
undetectable
3gv1C-3csgA:
undetectable		 3gv1A-3csgA:
13.67
3gv1C-3csgA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.33A 3gv1A-3dm0A:
undetectable
3gv1C-3dm0A:
undetectable		 3gv1A-3dm0A:
11.01
3gv1C-3dm0A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3erw SPORULATION
THIOL-DISULFIDE
OXIDOREDUCTASE A

(Bacillus
subtilis) 		PF00578
(AhpC-TSA) 		4 PRO A 135
HIS A  59
LEU A  72
PRO A 153
 None
 1.32A 3gv1A-3erwA:
6.1
3gv1C-3erwA:
5.9		 3gv1A-3erwA:
21.69
3gv1C-3erwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fij LIN1909 PROTEIN

(Listeria
innocua) 		PF07722
(Peptidase_C26) 		4 PRO A  44
LEU A  66
LYS A  30
ALA A  36
 None
 1.22A 3gv1A-3fijA:
undetectable
3gv1C-3fijA:
undetectable		 3gv1A-3fijA:
22.99
3gv1C-3fijA:
22.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gv1 DISULFIDE
INTERCHANGE PROTEIN

(Neisseria
gonorrhoeae) 		PF13098
(Thioredoxin_2) 		4 LEU A 125
LYS A 139
ALA A 141
PRO A 238
 None
 0.23A 3gv1A-3gv1A:
32.0
3gv1C-3gv1A:
30.0		 3gv1A-3gv1A:
100.00
3gv1C-3gv1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.27A 3gv1A-3h4zA:
undetectable
3gv1C-3h4zA:
undetectable		 3gv1A-3h4zA:
14.78
3gv1C-3h4zA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kpa PROBABLE UBIQUITIN
FOLD MODIFIER
CONJUGATING ENZYME

(Leishmania
major) 		PF08694
(UFC1) 		4 PRO A  13
HIS A 135
LEU A  15
ALA A  36
 None
 1.19A 3gv1A-3kpaA:
undetectable
3gv1C-3kpaA:
undetectable		 3gv1A-3kpaA:
18.93
3gv1C-3kpaA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 PRO A 306
LEU A 286
ALA A 228
PRO A 305
 None
 1.34A 3gv1A-3lkdA:
undetectable
3gv1C-3lkdA:
undetectable		 3gv1A-3lkdA:
15.31
3gv1C-3lkdA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkb HEMOGLOBIN SUBUNIT
ALPHA

(Isurus
oxyrinchus) 		PF00042
(Globin) 		4 HIS A  87
LEU A  83
LYS A  61
ALA A  65
 HEM  A 141 (-3.3A)
HEM  A 141 ( 4.8A)
HEM  A 141 ( 4.7A)
HEM  A 141 (-3.5A)
 1.26A 3gv1A-3mkbA:
undetectable
3gv1C-3mkbA:
undetectable		 3gv1A-3mkbA:
21.71
3gv1C-3mkbA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		4 PRO A 864
LEU A 885
ALA A 961
PRO A 863
 None
 1.32A 3gv1A-3mp6A:
undetectable
3gv1C-3mp6A:
undetectable		 3gv1A-3mp6A:
13.60
3gv1C-3mp6A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq9 BONE MARROW STROMAL
ANTIGEN 2 FUSED TO
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16716
(BST2) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-3mq9A:
undetectable
3gv1C-3mq9A:
undetectable		 3gv1A-3mq9A:
14.44
3gv1C-3mq9A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mr0 SENSORY BOX
HISTIDINE
KINASE/RESPONSE
REGULATOR

(Burkholderia
thailandensis) 		PF08447
(PAS_3) 		4 PRO A  24
LEU A  69
ALA A 101
PRO A 109
 None
PG5  A 143 ( 4.9A)
None
None
 1.32A 3gv1A-3mr0A:
undetectable
3gv1C-3mr0A:
undetectable		 3gv1A-3mr0A:
21.02
3gv1C-3mr0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.32A 3gv1A-3oaiA:
undetectable
3gv1C-3oaiA:
undetectable		 3gv1A-3oaiA:
14.00
3gv1C-3oaiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.34A 3gv1A-3osrA:
undetectable
3gv1C-3osrA:
undetectable		 3gv1A-3osrA:
11.45
3gv1C-3osrA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L2P

(Haloarcula
marismortui) 		PF00181
(Ribosomal_L2)
PF03947
(Ribosomal_L2_C) 		4 HIS A 131
LEU A 128
ALA A 154
PRO A  95
 None
 1.16A 3gv1A-3ow2A:
undetectable
3gv1C-3ow2A:
undetectable		 3gv1A-3ow2A:
16.94
3gv1C-3ow2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A  96
LYS A 126
ALA A  19
PRO A  74
 None
 1.21A 3gv1A-3pv4A:
undetectable
3gv1C-3pv4A:
undetectable		 3gv1A-3pv4A:
16.67
3gv1C-3pv4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 PRO A 374
LEU A 313
ALA A 366
PRO A 413
 None
 0.94A 3gv1A-3qp9A:
undetectable
3gv1C-3qp9A:
undetectable		 3gv1A-3qp9A:
12.48
3gv1C-3qp9A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		4 PRO A 250
LYS A 226
ALA A 222
PRO A 229
 None
None
EDO  A 910 (-3.7A)
EDO  A 907 (-4.4A)
 1.30A 3gv1A-3s1sA:
undetectable
3gv1C-3s1sA:
undetectable		 3gv1A-3s1sA:
9.91
3gv1C-3s1sA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 PRO A  53
HIS A  55
LEU A  91
ALA A  32
 None
 1.09A 3gv1A-3s2uA:
undetectable
3gv1C-3s2uA:
2.2		 3gv1A-3s2uA:
16.71
3gv1C-3s2uA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3l TABLYSIN 15

(Tabanus yao) 		PF00188
(CAP) 		4 LEU C 219
LYS C  56
ALA C  64
PRO C 205
 None
 1.30A 3gv1A-3u3lC:
undetectable
3gv1C-3u3lC:
undetectable		 3gv1A-3u3lC:
19.23
3gv1C-3u3lC:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgq INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 5

(Homo sapiens) 		PF07719
(TPR_2)
PF13181
(TPR_8)
PF13374
(TPR_10)
PF13424
(TPR_12) 		4 LEU A 475
LYS A 463
ALA A 461
PRO A 466
 None
 1.07A 3gv1A-3zgqA:
undetectable
3gv1C-3zgqA:
undetectable		 3gv1A-3zgqA:
16.55
3gv1C-3zgqA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P
SAR1P

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00025
(Arf) 		4 HIS B  56
LEU A 371
ALA A 607
PRO A 603
 None
 1.20A 3gv1A-4bziB:
undetectable
3gv1C-4bziB:
undetectable		 3gv1A-4bziB:
21.46
3gv1C-4bziB:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 HIS A 848
LEU A 885
ALA A 857
PRO A 851
 CD  A1990 (-3.3A)
None
None
None
 0.78A 3gv1A-4cvuA:
undetectable
3gv1C-4cvuA:
undetectable		 3gv1A-4cvuA:
9.65
3gv1C-4cvuA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.34A 3gv1A-4dxbA:
undetectable
3gv1C-4dxbA:
undetectable		 3gv1A-4dxbA:
12.40
3gv1C-4dxbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.32A 3gv1A-4exkA:
undetectable
3gv1C-4exkA:
undetectable		 3gv1A-4exkA:
13.14
3gv1C-4exkA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 PRO A  57
HIS A  31
LEU A  59
ALA A  83
 None
 1.31A 3gv1A-4g8dA:
1.5
3gv1C-4g8dA:
undetectable		 3gv1A-4g8dA:
22.58
3gv1C-4g8dA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 PRO A-244
LEU A-223
ALA A-147
PRO A-245
 None
 1.33A 3gv1A-4h1gA:
undetectable
3gv1C-4h1gA:
undetectable		 3gv1A-4h1gA:
11.42
3gv1C-4h1gA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 PRO A 705
HIS A 753
LEU A 679
ALA A 701
 None
 1.34A 3gv1A-4iglA:
undetectable
3gv1C-4iglA:
undetectable		 3gv1A-4iglA:
6.60
3gv1C-4iglA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.29A 3gv1A-4ikmA:
undetectable
3gv1C-4ikmA:
undetectable		 3gv1A-4ikmA:
16.20
3gv1C-4ikmA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.33A 3gv1A-4irlA:
undetectable
3gv1C-4irlA:
undetectable		 3gv1A-4irlA:
15.97
3gv1C-4irlA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 PRO A 138
HIS A 202
LYS A 212
ALA A 214
 None
 1.14A 3gv1A-4jclA:
undetectable
3gv1C-4jclA:
undetectable		 3gv1A-4jclA:
10.77
3gv1C-4jclA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		4 PRO A 480
LEU A 331
ALA A 321
PRO A 438
 None
 1.33A 3gv1A-4k5rA:
undetectable
3gv1C-4k5rA:
1.7		 3gv1A-4k5rA:
13.99
3gv1C-4k5rA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.33A 3gv1A-4kegA:
undetectable
3gv1C-4kegA:
undetectable		 3gv1A-4kegA:
13.02
3gv1C-4kegA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.25A 3gv1A-4logA:
undetectable
3gv1C-4logA:
undetectable		 3gv1A-4logA:
12.63
3gv1C-4logA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 PRO A 402
LEU A 473
ALA A 391
PRO A 464
 None
 1.33A 3gv1A-4mh1A:
undetectable
3gv1C-4mh1A:
undetectable		 3gv1A-4mh1A:
12.99
3gv1C-4mh1A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		4 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.34A 3gv1A-4my2A:
undetectable
3gv1C-4my2A:
undetectable		 3gv1A-4my2A:
14.01
3gv1C-4my2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 1

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 HIS A 271
LEU A  12
ALA A  58
PRO A 280
 None
 1.27A 3gv1A-4nhdA:
undetectable
3gv1C-4nhdA:
undetectable		 3gv1A-4nhdA:
15.89
3gv1C-4nhdA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 PRO A-244
LEU A-223
ALA A-147
PRO A-245
 None
 1.33A 3gv1A-4ozqA:
undetectable
3gv1C-4ozqA:
undetectable		 3gv1A-4ozqA:
11.89
3gv1C-4ozqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 HIS A 693
LEU A 696
ALA A  99
PRO A  39
 None
 1.19A 3gv1A-4pd3A:
undetectable
3gv1C-4pd3A:
undetectable		 3gv1A-4pd3A:
9.11
3gv1C-4pd3A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmd ENVOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		4 PRO A1985
LEU A1858
ALA A1996
PRO A2012
 None
 1.32A 3gv1A-4qmdA:
undetectable
3gv1C-4qmdA:
undetectable		 3gv1A-4qmdA:
20.73
3gv1C-4qmdA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.33A 3gv1A-4r0yA:
undetectable
3gv1C-4r0yA:
undetectable		 3gv1A-4r0yA:
15.37
3gv1C-4r0yA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		4 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.30A 3gv1A-4rwfA:
undetectable
3gv1C-4rwfA:
undetectable		 3gv1A-4rwfA:
12.67
3gv1C-4rwfA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 PRO A 903
LEU A 842
ALA A 878
PRO A 876
 None
 1.31A 3gv1A-4ts6A:
undetectable
3gv1C-4ts6A:
undetectable		 3gv1A-4ts6A:
23.72
3gv1C-4ts6A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-4tsmA:
undetectable
3gv1C-4tsmA:
undetectable		 3gv1A-4tsmA:
15.58
3gv1C-4tsmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 PRO A 458
HIS A 256
LEU A 460
ALA A 475
 None
 1.33A 3gv1A-4uphA:
undetectable
3gv1C-4uphA:
undetectable		 3gv1A-4uphA:
12.88
3gv1C-4uphA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqm URACIL-DNA
GLYCOSYLASE

(Deinococcus
radiodurans) 		PF03167
(UDG) 		4 HIS A 155
LEU A  47
ALA A  60
PRO A  58
 None
 0.94A 3gv1A-4uqmA:
undetectable
3gv1C-4uqmA:
undetectable		 3gv1A-4uqmA:
17.67
3gv1C-4uqmA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrn MALTOSE-BINDING
PERIPLASMIC
PROTEIN,UROMODULIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 PRO A 150
LEU A 171
ALA A 247
PRO A 149
 None
 1.24A 3gv1A-4wrnA:
undetectable
3gv1C-4wrnA:
undetectable		 3gv1A-4wrnA:
10.07
3gv1C-4wrnA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		4 PRO A  30
HIS A  25
LEU A  22
ALA A  34
 None
 1.30A 3gv1A-4wx6A:
undetectable
3gv1C-4wx6A:
undetectable		 3gv1A-4wx6A:
19.80
3gv1C-4wx6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus) 		PF13088
(BNR_2) 		4 PRO A 304
LEU A 306
LYS A 252
ALA A 275
 None
 1.21A 3gv1A-4x6kA:
undetectable
3gv1C-4x6kA:
undetectable		 3gv1A-4x6kA:
14.55
3gv1C-4x6kA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.34A 3gv1A-4xa2A:
undetectable
3gv1C-4xa2A:
undetectable		 3gv1A-4xa2A:
15.66
3gv1C-4xa2A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d PINS
INSCUTEABLE

(Drosophila
melanogaster;
Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 PRO L 323
HIS B 172
LEU B 230
ALA L 320
 None
 0.93A 3gv1A-5a7dL:
undetectable
3gv1C-5a7dL:
undetectable		 3gv1A-5a7dL:
16.51
3gv1C-5a7dL:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.30A 3gv1A-5azaA:
undetectable
3gv1C-5azaA:
undetectable		 3gv1A-5azaA:
10.89
3gv1C-5azaA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-5cfvA:
undetectable
3gv1C-5cfvA:
undetectable		 3gv1A-5cfvA:
15.96
3gv1C-5cfvA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		4 PRO A 128
LEU A 149
ALA A 225
PRO A 127
 None
 1.33A 3gv1A-5gxvA:
undetectable
3gv1C-5gxvA:
undetectable		 3gv1A-5gxvA:
14.10
3gv1C-5gxvA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		4 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.34A 3gv1A-5h7nA:
undetectable
3gv1C-5h7nA:
undetectable		 3gv1A-5h7nA:
17.15
3gv1C-5h7nA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		4 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.32A 3gv1A-5hz7A:
undetectable
3gv1C-5hz7A:
undetectable		 3gv1A-5hz7A:
15.13
3gv1C-5hz7A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 PRO A 493
LEU A 514
ALA A 590
PRO A 492
 None
 1.28A 3gv1A-5hzvA:
undetectable
3gv1C-5hzvA:
undetectable		 3gv1A-5hzvA:
13.26
3gv1C-5hzvA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 PRO A3793
LEU A3814
ALA A3890
PRO A3792
 None
 1.27A 3gv1A-5ii5A:
undetectable
3gv1C-5ii5A:
undetectable		 3gv1A-5ii5A:
13.77
3gv1C-5ii5A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 PRO A 103
HIS A 136
LEU A  14
ALA A 101
 None
 1.31A 3gv1A-5jygA:
undetectable
3gv1C-5jygA:
undetectable		 3gv1A-5jygA:
17.29
3gv1C-5jygA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 PRO A 341
HIS A 301
ALA A 363
PRO A 366
 None
 1.28A 3gv1A-5ltaA:
undetectable
3gv1C-5ltaA:
undetectable		 3gv1A-5ltaA:
10.36
3gv1C-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.27A 3gv1A-5osqA:
undetectable
3gv1C-5osqA:
undetectable		 3gv1A-5osqA:
16.63
3gv1C-5osqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-5t03A:
undetectable
3gv1C-5t03A:
undetectable		 3gv1A-5t03A:
11.67
3gv1C-5t03A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-5tj2A:
undetectable
3gv1C-5tj2A:
undetectable		 3gv1A-5tj2A:
12.84
3gv1C-5tj2A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		4 PRO A 132
LEU A 153
ALA A 229
PRO A 131
 None
 1.32A 3gv1A-5ttdA:
undetectable
3gv1C-5ttdA:
undetectable		 3gv1A-5ttdA:
12.83
3gv1C-5ttdA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 4 HIS A 141
LEU A 132
LYS A  72
ALA A  76
 None
 1.25A 3gv1A-5wnmA:
undetectable
3gv1C-5wnmA:
undetectable		 3gv1A-5wnmA:
undetectable
3gv1C-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 PRO A 590
HIS A 301
LEU A 281
ALA A 563
 None
 1.27A 3gv1A-5x3jA:
undetectable
3gv1C-5x3jA:
undetectable		 3gv1A-5x3jA:
undetectable
3gv1C-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 4 HIS A 227
LEU A 257
ALA A 242
PRO A 255
 None
 1.32A 3gv1A-5xpgA:
undetectable
3gv1C-5xpgA:
undetectable		 3gv1A-5xpgA:
undetectable
3gv1C-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 4 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.30A 3gv1A-6apxA:
undetectable
3gv1C-6apxA:
undetectable		 3gv1A-6apxA:
16.35
3gv1C-6apxA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 HIS 1 226
LEU 1 156
LYS 1 260
ALA 1 262
 None
 1.24A 3gv1A-6c261:
undetectable
3gv1C-6c261:
undetectable		 3gv1A-6c261:
undetectable
3gv1C-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 4 PRO A 150
LEU A 296
ALA A 332
PRO A 237
 None
 1.18A 3gv1A-6f8yA:
undetectable
3gv1C-6f8yA:
undetectable		 3gv1A-6f8yA:
undetectable
3gv1C-6f8yA:
undetectable