SIMILAR PATTERNS OF AMINO ACIDS FOR 3GP0_A_NILA1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  54
LEU A  78
ILE A  87
HIS A 151
ALA A 160
LEU A 170
ASP A 171
 ANP  A 400 (-3.3A)
None
ANP  A 400 (-4.9A)
None
ANP  A 400 ( 4.7A)
ANP  A 400 (-4.0A)
MG  A 402 (-2.3A)
 1.04A 3gp0A-1cm8A:
37.8		 3gp0A-1cm8A:
63.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  41
ALA A  54
GLU A  74
LEU A  77
LEU A  78
ILE A  87
HIS A 151
ALA A 160
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
None
None
None
ANP  A 400 (-4.9A)
None
ANP  A 400 ( 4.7A)
ANP  A 400 (-4.0A)
 0.76A 3gp0A-1cm8A:
37.8		 3gp0A-1cm8A:
63.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A 172
ALA A 185
GLU A 202
LEU A 205
LEU A 206
HIS A 292
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
 0.83A 3gp0A-1q8yA:
25.9		 3gp0A-1q8yA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
LEU A 644
THR A 670
HIS A 790
ASP A 810
PHE A 811
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.73A 3gp0A-1t46A:
16.2		 3gp0A-1t46A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
ASP A 169
 None
 1.08A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
 None
 0.47A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		6 VAL A  14
ALA A  36
LEU A  57
THR A  32
LEU A  27
PHE A  87
 None
 1.17A 3gp0A-1wvgA:
undetectable		 3gp0A-1wvgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 6 VAL A  90
LEU A  73
ILE A  71
LEU A 152
ASP A 148
PHE A 141
 None
 1.18A 3gp0A-1yc6A:
undetectable		 3gp0A-1yc6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 None
 1.24A 3gp0A-1zwsA:
22.6		 3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 None
 0.71A 3gp0A-1zwsA:
22.6		 3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 (-4.8A)
None
 0.54A 3gp0A-2a2aA:
22.6		 3gp0A-2a2aA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
GLU A 678
ILE A 691
THR A 707
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 1.10A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
GLU A 678
ILE A 691
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.85A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
GLU A 286
THR A 315
HIS A 361
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 1.13A 3gp0A-2hz0A:
21.8		 3gp0A-2hz0A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 256
ALA A 269
GLU A 286
THR A 315
HIS A 361
PHE A 382
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.0A)
 1.15A 3gp0A-2hz0A:
21.8		 3gp0A-2hz0A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  46
ALA A  59
GLU A  83
LEU A  86
LEU A  87
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
None
None
 0.86A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  46
ALA A  59
GLU A  83
LEU A  87
ILE A 100
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.1A)
None
 0.93A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
GLU A 288
LEU A 291
THR A 316
HIS A 362
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 3.3A)
 0.53A 3gp0A-2og8A:
22.1		 3gp0A-2og8A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
GLU A 633
HIS A 776
ASP A 796
PHE A 797
 None
 1.01A 3gp0A-2ogvA:
21.2		 3gp0A-2ogvA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
GLU A 633
THR A 663
HIS A 776
ASP A 796
 None
 0.69A 3gp0A-2ogvA:
21.2		 3gp0A-2ogvA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
LEU A 876
ILE A 886
HIS A 962
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.2A)
 0.82A 3gp0A-2p4iA:
6.6		 3gp0A-2p4iA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
GLU A  73
LEU A  77
ILE A  87
HIS A 147
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
 0.83A 3gp0A-2phkA:
22.8		 3gp0A-2phkA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 651
GLU A 670
ILE A 683
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.26A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.01A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 449
GLU A 463
LEU A 467
ILE A 477
THR A 493
HIS A 537
 None
 0.57A 3gp0A-2qr7A:
19.1		 3gp0A-2qr7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLU A 463
LEU A 467
ILE A 477
THR A 493
HIS A 537
ASP A 561
 None
 1.25A 3gp0A-2qr7A:
19.1		 3gp0A-2qr7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
GLU A 724
ILE A 737
THR A 753
HIS A 798
ASP A 818
 None
 1.28A 3gp0A-2r2pA:
21.8		 3gp0A-2r2pA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
MG  A1304 ( 2.8A)
 1.16A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
 0.59A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 445
LEU A 463
ILE A 473
THR A 489
HIS A 533
ASP A 557
 None
 1.08A 3gp0A-2wntA:
18.9		 3gp0A-2wntA:
29.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL C  63
ALA C  76
GLU C  98
LEU C 101
LEU C 102
ILE C 111
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.93A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL C  63
ALA C  76
LEU C 101
LEU C 102
ILE C 111
HIS C 174
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.79A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 683
THR A 699
HIS A 744
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
None
None
 0.81A 3gp0A-2xyuA:
22.1		 3gp0A-2xyuA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
AMP  A1302 (-3.1A)
 1.16A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
 0.60A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LEU A 293
THR A 319
HIS A 365
ASP A 385
 None
 0.98A 3gp0A-2zv7A:
21.8		 3gp0A-2zv7A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		6 VAL A 671
LEU A 624
LEU A 628
ILE A 689
THR A 632
LEU A 602
 None
 1.20A 3gp0A-3a5iA:
undetectable		 3gp0A-3a5iA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
4RB  A 401 ( 4.3A)
None
GOL  A 503 ( 3.1A)
 1.17A 3gp0A-3bqrA:
21.0		 3gp0A-3bqrA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
4RB  A 401 ( 4.3A)
None
 0.65A 3gp0A-3bqrA:
21.0		 3gp0A-3bqrA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  39
ALA A  52
GLU A  72
LEU A  75
LEU A  76
ILE A  85
HIS A 148
ALA A 157
LEU A 167
 None
 0.80A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  39
GLU A  72
LEU A  75
LEU A  76
HIS A 148
ASP A 168
 None
 1.08A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  40
ALA A  53
GLU A  73
LEU A  76
LEU A  77
ILE A  86
LEU A 168
ASP A 169
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
None
None
None
35F  A   1 (-4.5A)
None
 0.73A 3gp0A-3e7oA:
35.7		 3gp0A-3e7oA:
49.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  40
GLU A  73
LEU A  76
LEU A  77
HIS A 149
ASP A 169
 35F  A   1 ( 4.8A)
None
None
None
None
None
 1.00A 3gp0A-3e7oA:
35.7		 3gp0A-3e7oA:
49.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.64A 3gp0A-3f2aA:
17.1		 3gp0A-3f2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
LEU A 882
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.76A 3gp0A-3hngA:
22.6		 3gp0A-3hngA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
ILE A 697
THR A 713
HIS A 758
 None
 0.74A 3gp0A-3kulA:
22.2		 3gp0A-3kulA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 700
GLU A 715
LEU A 719
ILE A 729
HIS A 795
ASP A 828
 ADP  A2101 (-3.5A)
None
None
None
None
SR  A2103 (-2.6A)
 1.27A 3gp0A-3lj0A:
20.9		 3gp0A-3lj0A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
GLU A 715
LEU A 719
ILE A 729
HIS A 795
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
None
None
 0.83A 3gp0A-3lj0A:
20.9		 3gp0A-3lj0A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A 566
ALA A 579
GLU A 596
LEU A 600
HIS A 675
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
ANP  A 877 (-2.9A)
 1.08A 3gp0A-3lltA:
24.7		 3gp0A-3lltA:
24.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  75
LEU A  79
ILE A  88
HIS A 152
 None
GOL  A 434 ( 4.1A)
GOL  A 433 ( 4.8A)
None
None
None
 1.09A 3gp0A-3n9xA:
33.8		 3gp0A-3n9xA:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
GLU A  77
LEU A  81
ILE A  90
HIS A 154
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 ( 4.5A)
None
 1.03A 3gp0A-3nieA:
34.6		 3gp0A-3nieA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
LEU A  81
ILE A  90
HIS A 154
ASP A 174
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
None
ANP  A 430 ( 4.5A)
None
ANP  A 430 (-2.8A)
 1.12A 3gp0A-3nieA:
34.6		 3gp0A-3nieA:
33.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		6 VAL B 158
ALA B  76
LEU B 184
LEU B 181
ILE B 217
ALA B 220
 None
 1.28A 3gp0A-3o0rB:
undetectable		 3gp0A-3o0rB:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
GLU A  72
ILE A  85
THR A 107
ALA A 158
LEU A 168
PHE A 170
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
1N1  A1000 (-4.5A)
 1.01A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		7 VAL A  39
ALA A  52
GLU A  72
LEU A  75
LEU A  76
THR A 107
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.64A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
GLU A  72
LEU A  76
ILE A  85
THR A 107
ALA A 158
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
 0.69A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
GLU A 115
LEU A 119
ILE A 128
THR A 144
HIS A 188
ASP A 211
 ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.6A)
None
MG  A 529 (-2.2A)
 1.19A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 VAL A  71
ALA A  84
GLU A 115
LEU A 118
LEU A 119
ILE A 128
THR A 144
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
None
ANP  A1634 (-4.6A)
None
 0.65A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.74A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.78A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
 0.53A 3gp0A-3vidA:
21.5		 3gp0A-3vidA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.86A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
LEU A 889
HIS A1026
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.95A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
LEU A  55
HIS A 124
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
None
None
D15  A 500 (-3.7A)
 0.96A 3gp0A-4aguA:
28.7		 3gp0A-4aguA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  69
ALA A  82
LEU A 106
ILE A 115
HIS A 180
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
None
None
 1.00A 3gp0A-4b99A:
37.6		 3gp0A-4b99A:
43.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 653
GLU A 672
ILE A 685
THR A 701
HIS A 764
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.1A)
 0.48A 3gp0A-4ckrA:
22.2		 3gp0A-4ckrA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 653
LEU A 679
THR A 701
HIS A 764
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.1A)
 1.26A 3gp0A-4ckrA:
22.2		 3gp0A-4ckrA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
GLU A  77
LEU A  81
HIS A 152
ALA A 161
LEU A 175
 2KC  A 401 (-2.7A)
2KC  A 401 (-1.9A)
None
None
None
2KC  A 401 ( 3.9A)
 1.21A 3gp0A-4nfnA:
18.8		 3gp0A-4nfnA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
GLU A 947
LEU A 951
ILE A 960
HIS A1021
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
None
None
 1.05A 3gp0A-4oliA:
21.1		 3gp0A-4oliA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 627
ALA A 644
GLU A 663
ILE A 676
THR A 692
ASP A 757
 None
 1.19A 3gp0A-4p2kA:
19.7		 3gp0A-4p2kA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 VAL A  35
ALA A  49
GLU A  70
LEU A  73
LEU A  74
ILE A  83
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.0A)
None
None
ANP  A 402 (-4.8A)
 0.52A 3gp0A-4qnyA:
35.8		 3gp0A-4qnyA:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  49
LEU A  73
LEU A  74
ILE A  83
HIS A 147
ASP A 167
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
None
None
ANP  A 402 (-4.8A)
None
ANP  A 402 ( 2.6A)
 0.96A 3gp0A-4qnyA:
35.8		 3gp0A-4qnyA:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  56
ALA A  69
GLU A  88
LEU A  92
ILE A 101
ASP A 184
 None
38Z  A 418 (-3.4A)
38Z  A 418 (-3.4A)
None
38Z  A 418 ( 4.9A)
38Z  A 418 (-3.5A)
 1.18A 3gp0A-4qtbA:
37.4		 3gp0A-4qtbA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  56
ALA A  69
LEU A  92
ILE A 101
HIS A 164
ASP A 184
 None
38Z  A 418 (-3.4A)
None
38Z  A 418 ( 4.9A)
None
38Z  A 418 (-3.5A)
 1.07A 3gp0A-4qtbA:
37.4		 3gp0A-4qtbA:
45.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
 0.88A 3gp0A-4rt7A:
22.6		 3gp0A-4rt7A:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
ALA B 157
LEU B 167
ASP B 168
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 1.08A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
HIS B 148
ALA B 157
LEU B 167
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.85A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		9 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
ALA B 157
LEU B 167
ASP B 168
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.98A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		9 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
HIS B 148
ALA B 157
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.90A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
GLU A  52
THR A  81
HIS A 127
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 1.15A 3gp0A-4ueuA:
21.8		 3gp0A-4ueuA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		6 ALA A 131
LEU A 417
LEU A 481
ILE A 485
ALA A 493
LEU A 410
 None
 1.09A 3gp0A-4x9eA:
undetectable		 3gp0A-4x9eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.80A 3gp0A-4xufA:
22.0		 3gp0A-4xufA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
GLU A 509
LEU A 513
ILE A 522
THR A 539
HIS A 586
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
None
 0.64A 3gp0A-4yffA:
20.6		 3gp0A-4yffA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
GLU A  76
LEU A  80
THR A 105
HIS A 149
ASP A 172
 ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 ( 2.4A)
 1.25A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  42
ALA A  55
GLU A  76
LEU A  79
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
ADP  A 506 ( 4.6A)
None
 0.78A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 VAL A 586
ALA A 597
GLU A 612
LEU A 615
LEU A 616
ILE A 626
HIS A 686
 None
 0.97A 3gp0A-4z7gA:
18.8		 3gp0A-4z7gA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
 1.10A 3gp0A-5fm2A:
21.3		 3gp0A-5fm2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
GLU A 644
THR A 674
HIS A 816
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.83A 3gp0A-5grnA:
11.2		 3gp0A-5grnA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
LEU A  69
LEU A  70
ILE A  79
HIS A 149
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
 0.95A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
LEU A  70
ILE A  79
HIS A 149
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
FMT  A 403 ( 3.3A)
 1.15A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
ALA A 663
ILE A 695
THR A 711
HIS A 756
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
DIO  A1002 (-4.1A)
None
 0.62A 3gp0A-5l6oA:
22.1		 3gp0A-5l6oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
ALA A 176
GLU A 193
LEU A 197
ILE A 212
HIS A 273
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
None
 0.88A 3gp0A-5lxdA:
25.8		 3gp0A-5lxdA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
GLU A 136
LEU A 139
LEU A 140
HIS A 223
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
None
 0.99A 3gp0A-5myvA:
20.9		 3gp0A-5myvA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 0.65A 3gp0A-5turA:
21.5		 3gp0A-5turA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A  94
ALA A 107
GLU A 124
LEU A 127
LEU A 128
HIS A 211
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
None
 0.87A 3gp0A-5xv7A:
25.4		 3gp0A-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  57
ALA A  70
GLU A  85
LEU A  89
ILE A  99
HIS A 158
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.4A)
None
None
ATP  A 403 (-4.9A)
None
 0.55A 3gp0A-5xvuA:
25.8		 3gp0A-5xvuA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 VAL A 701
ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.70A 3gp0A-6cnhA:
26.9		 3gp0A-6cnhA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 VAL A 177
ALA A 191
GLU A 208
LEU A 212
HIS A 288
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
3NG  A 501 (-4.5A)
 1.08A 3gp0A-6fylA:
25.8		 3gp0A-6fylA:
undetectable