SIMILAR PATTERNS OF AMINO ACIDS FOR 3GP0_A_NILA1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  54
LEU A  78
ILE A  87
HIS A 151
ALA A 160
LEU A 170
ASP A 171
 ANP  A 400 (-3.3A)
None
ANP  A 400 (-4.9A)
None
ANP  A 400 ( 4.7A)
ANP  A 400 (-4.0A)
MG  A 402 (-2.3A)
 1.04A 3gp0A-1cm8A:
37.8		 3gp0A-1cm8A:
63.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  41
ALA A  54
GLU A  74
LEU A  77
LEU A  78
ILE A  87
HIS A 151
ALA A 160
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
None
None
None
ANP  A 400 (-4.9A)
None
ANP  A 400 ( 4.7A)
ANP  A 400 (-4.0A)
 0.76A 3gp0A-1cm8A:
37.8		 3gp0A-1cm8A:
63.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A 172
ALA A 185
GLU A 202
LEU A 205
LEU A 206
HIS A 292
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
 0.83A 3gp0A-1q8yA:
25.9		 3gp0A-1q8yA:
28.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
GLU A 640
LEU A 644
THR A 670
HIS A 790
ASP A 810
PHE A 811
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.73A 3gp0A-1t46A:
16.2		 3gp0A-1t46A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
ASP A 169
 None
 1.08A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  76
LEU A  80
ILE A  89
HIS A 149
 None
 0.47A 3gp0A-1u5qA:
23.0		 3gp0A-1u5qA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		6 VAL A  14
ALA A  36
LEU A  57
THR A  32
LEU A  27
PHE A  87
 None
 1.17A 3gp0A-1wvgA:
undetectable		 3gp0A-1wvgA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 6 VAL A  90
LEU A  73
ILE A  71
LEU A 152
ASP A 148
PHE A 141
 None
 1.18A 3gp0A-1yc6A:
undetectable		 3gp0A-1yc6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 None
 1.24A 3gp0A-1zwsA:
22.6		 3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 None
 0.71A 3gp0A-1zwsA:
22.6		 3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 None
GOL  A3001 (-3.5A)
None
None
GOL  A3001 (-4.8A)
None
 0.54A 3gp0A-2a2aA:
22.6		 3gp0A-2a2aA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
GLU A 678
ILE A 691
THR A 707
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.8A)
 1.10A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
GLU A 678
ILE A 691
THR A 707
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.8A)
 0.85A 3gp0A-2henA:
21.8		 3gp0A-2henA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
GLU A 286
THR A 315
HIS A 361
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 1.13A 3gp0A-2hz0A:
21.8		 3gp0A-2hz0A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 256
ALA A 269
GLU A 286
THR A 315
HIS A 361
PHE A 382
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.0A)
 1.15A 3gp0A-2hz0A:
21.8		 3gp0A-2hz0A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  46
ALA A  59
GLU A  83
LEU A  86
LEU A  87
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
None
None
 0.86A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  46
ALA A  59
GLU A  83
LEU A  87
ILE A 100
HIS A 161
 HB1  A1289 (-3.6A)
HB1  A1289 ( 3.7A)
None
None
HB1  A1289 (-4.1A)
None
 0.93A 3gp0A-2iwiA:
20.5		 3gp0A-2iwiA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
GLU A 288
LEU A 291
THR A 316
HIS A 362
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
None
1N8  A 501 ( 3.3A)
 0.53A 3gp0A-2og8A:
22.1		 3gp0A-2og8A:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
GLU A 633
HIS A 776
ASP A 796
PHE A 797
 None
 1.01A 3gp0A-2ogvA:
21.2		 3gp0A-2ogvA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
GLU A 633
THR A 663
HIS A 776
ASP A 796
 None
 0.69A 3gp0A-2ogvA:
21.2		 3gp0A-2ogvA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
LEU A 876
ILE A 886
HIS A 962
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 (-4.0A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.2A)
 0.82A 3gp0A-2p4iA:
6.6		 3gp0A-2p4iA:
25.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 VAL A  33
ALA A  46
GLU A  73
LEU A  77
ILE A  87
HIS A 147
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
None
 0.83A 3gp0A-2phkA:
22.8		 3gp0A-2phkA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 651
GLU A 670
ILE A 683
THR A 699
HIS A 744
ASP A 764
 PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.26A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
GLU A 670
ILE A 683
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
 1.01A 3gp0A-2qobA:
21.9		 3gp0A-2qobA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 449
GLU A 463
LEU A 467
ILE A 477
THR A 493
HIS A 537
 None
 0.57A 3gp0A-2qr7A:
19.1		 3gp0A-2qr7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLU A 463
LEU A 467
ILE A 477
THR A 493
HIS A 537
ASP A 561
 None
 1.25A 3gp0A-2qr7A:
19.1		 3gp0A-2qr7A:
29.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
GLU A 724
ILE A 737
THR A 753
HIS A 798
ASP A 818
 None
 1.28A 3gp0A-2r2pA:
21.8		 3gp0A-2r2pA:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
MG  A1304 ( 2.8A)
 1.16A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 ( 4.8A)
None
ADP  A1303 ( 4.2A)
None
 0.59A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 445
LEU A 463
ILE A 473
THR A 489
HIS A 533
ASP A 557
 None
 1.08A 3gp0A-2wntA:
18.9		 3gp0A-2wntA:
29.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL C  63
ALA C  76
GLU C  98
LEU C 101
LEU C 102
ILE C 111
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.93A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL C  63
ALA C  76
LEU C 101
LEU C 102
ILE C 111
HIS C 174
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.79A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
ILE A 683
THR A 699
HIS A 744
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
None
None
 0.81A 3gp0A-2xyuA:
22.1		 3gp0A-2xyuA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
AMP  A1302 (-3.1A)
 1.16A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
None
None
AMP  A1302 ( 3.8A)
None
 0.60A 3gp0A-2yabA:
22.6		 3gp0A-2yabA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 261
ALA A 273
LEU A 293
THR A 319
HIS A 365
ASP A 385
 None
 0.98A 3gp0A-2zv7A:
21.8		 3gp0A-2zv7A:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5i FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		6 VAL A 671
LEU A 624
LEU A 628
ILE A 689
THR A 632
LEU A 602
 None
 1.20A 3gp0A-3a5iA:
undetectable		 3gp0A-3a5iA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
ASP A 161
 4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
4RB  A 401 ( 4.3A)
None
GOL  A 503 ( 3.1A)
 1.17A 3gp0A-3bqrA:
21.0		 3gp0A-3bqrA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
GLU A  64
LEU A  68
ILE A  77
HIS A 137
 4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
4RB  A 401 ( 4.3A)
None
 0.65A 3gp0A-3bqrA:
21.0		 3gp0A-3bqrA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  39
ALA A  52
GLU A  72
LEU A  75
LEU A  76
ILE A  85
HIS A 148
ALA A 157
LEU A 167
 None
 0.80A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  39
GLU A  72
LEU A  75
LEU A  76
HIS A 148
ASP A 168
 None
 1.08A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  40
ALA A  53
GLU A  73
LEU A  76
LEU A  77
ILE A  86
LEU A 168
ASP A 169
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
None
None
None
35F  A   1 (-4.5A)
None
 0.73A 3gp0A-3e7oA:
35.7		 3gp0A-3e7oA:
49.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  40
GLU A  73
LEU A  76
LEU A  77
HIS A 149
ASP A 169
 35F  A   1 ( 4.8A)
None
None
None
None
None
 1.00A 3gp0A-3e7oA:
35.7		 3gp0A-3e7oA:
49.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 985  A   1 (-4.5A)
985  A   1 (-3.5A)
MG  A 314 (-3.6A)
None
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.64A 3gp0A-3f2aA:
17.1		 3gp0A-3f2aA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
LEU A 882
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.76A 3gp0A-3hngA:
22.6		 3gp0A-3hngA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
GLU A 684
ILE A 697
THR A 713
HIS A 758
 None
 0.74A 3gp0A-3kulA:
22.2		 3gp0A-3kulA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 ALA A 700
GLU A 715
LEU A 719
ILE A 729
HIS A 795
ASP A 828
 ADP  A2101 (-3.5A)
None
None
None
None
SR  A2103 (-2.6A)
 1.27A 3gp0A-3lj0A:
20.9		 3gp0A-3lj0A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 VAL A 689
ALA A 700
GLU A 715
LEU A 719
ILE A 729
HIS A 795
 ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
None
None
 0.83A 3gp0A-3lj0A:
20.9		 3gp0A-3lj0A:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A 566
ALA A 579
GLU A 596
LEU A 600
HIS A 675
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
ANP  A 877 (-2.9A)
 1.08A 3gp0A-3lltA:
24.7		 3gp0A-3lltA:
24.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 VAL A  42
ALA A  55
GLU A  75
LEU A  79
ILE A  88
HIS A 152
 None
GOL  A 434 ( 4.1A)
GOL  A 433 ( 4.8A)
None
None
None
 1.09A 3gp0A-3n9xA:
33.8		 3gp0A-3n9xA:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
GLU A  77
LEU A  81
ILE A  90
HIS A 154
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 ( 4.5A)
None
 1.03A 3gp0A-3nieA:
34.6		 3gp0A-3nieA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  44
ALA A  57
LEU A  81
ILE A  90
HIS A 154
ASP A 174
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
None
ANP  A 430 ( 4.5A)
None
ANP  A 430 (-2.8A)
 1.12A 3gp0A-3nieA:
34.6		 3gp0A-3nieA:
33.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		6 VAL B 158
ALA B  76
LEU B 184
LEU B 181
ILE B 217
ALA B 220
 None
 1.28A 3gp0A-3o0rB:
undetectable		 3gp0A-3o0rB:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
GLU A  72
ILE A  85
THR A 107
ALA A 158
LEU A 168
PHE A 170
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
1N1  A1000 (-4.5A)
 1.01A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		7 VAL A  39
ALA A  52
GLU A  72
LEU A  75
LEU A  76
THR A 107
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
None
1N1  A1000 (-4.7A)
1N1  A1000 (-3.3A)
1N1  A1000 ( 3.7A)
 0.64A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
GLU A  72
LEU A  76
ILE A  85
THR A 107
ALA A 158
LEU A 168
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 ( 3.7A)
 0.69A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
GLU A 115
LEU A 119
ILE A 128
THR A 144
HIS A 188
ASP A 211
 ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.6A)
None
MG  A 529 (-2.2A)
 1.19A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 VAL A  71
ALA A  84
GLU A 115
LEU A 118
LEU A 119
ILE A 128
THR A 144
HIS A 188
 ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
None
ANP  A1634 (-4.6A)
None
 0.65A 3gp0A-3q5iA:
22.5		 3gp0A-3q5iA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.74A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 552
ALA A 570
LEU A 591
LEU A 592
HIS A 677
ASP A 697
 None
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.7A)
0F4  A 902 (-4.1A)
None
 0.78A 3gp0A-3v5qA:
22.6		 3gp0A-3v5qA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
 0.53A 3gp0A-3vidA:
21.5		 3gp0A-3vidA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
LEU A 889
HIS A1026
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.86A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
LEU A 889
HIS A1026
ASP A1046
PHE A1047
 None
B49  A2000 (-3.5A)
None
None
None
B49  A2000 (-4.0A)
 0.95A 3gp0A-4agdA:
21.8		 3gp0A-4agdA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
LEU A  55
HIS A 124
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
None
None
D15  A 500 (-3.7A)
 0.96A 3gp0A-4aguA:
28.7		 3gp0A-4aguA:
30.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  69
ALA A  82
LEU A 106
ILE A 115
HIS A 180
ASP A 200
 R4L  A1394 (-4.0A)
R4L  A1394 ( 3.7A)
None
R4L  A1394 (-4.9A)
None
None
 1.00A 3gp0A-4b99A:
37.6		 3gp0A-4b99A:
43.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 653
GLU A 672
ILE A 685
THR A 701
HIS A 764
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.1A)
 0.48A 3gp0A-4ckrA:
22.2		 3gp0A-4ckrA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 653
LEU A 679
THR A 701
HIS A 764
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.1A)
 1.26A 3gp0A-4ckrA:
22.2		 3gp0A-4ckrA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfn TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
GLU A  77
LEU A  81
HIS A 152
ALA A 161
LEU A 175
 2KC  A 401 (-2.7A)
2KC  A 401 (-1.9A)
None
None
None
2KC  A 401 ( 3.9A)
 1.21A 3gp0A-4nfnA:
18.8		 3gp0A-4nfnA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
ALA A 928
GLU A 947
LEU A 951
ILE A 960
HIS A1021
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
None
None
 1.05A 3gp0A-4oliA:
21.1		 3gp0A-4oliA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 627
ALA A 644
GLU A 663
ILE A 676
THR A 692
ASP A 757
 None
 1.19A 3gp0A-4p2kA:
19.7		 3gp0A-4p2kA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 VAL A  35
ALA A  49
GLU A  70
LEU A  73
LEU A  74
ILE A  83
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-3.0A)
None
None
ANP  A 402 (-4.8A)
 0.52A 3gp0A-4qnyA:
35.8		 3gp0A-4qnyA:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  49
LEU A  73
LEU A  74
ILE A  83
HIS A 147
ASP A 167
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
None
None
ANP  A 402 (-4.8A)
None
ANP  A 402 ( 2.6A)
 0.96A 3gp0A-4qnyA:
35.8		 3gp0A-4qnyA:
37.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  56
ALA A  69
GLU A  88
LEU A  92
ILE A 101
ASP A 184
 None
38Z  A 418 (-3.4A)
38Z  A 418 (-3.4A)
None
38Z  A 418 ( 4.9A)
38Z  A 418 (-3.5A)
 1.18A 3gp0A-4qtbA:
37.4		 3gp0A-4qtbA:
45.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  56
ALA A  69
LEU A  92
ILE A 101
HIS A 164
ASP A 184
 None
38Z  A 418 (-3.4A)
None
38Z  A 418 ( 4.9A)
None
38Z  A 418 (-3.5A)
 1.07A 3gp0A-4qtbA:
37.4		 3gp0A-4qtbA:
45.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
None
P30  A1001 (-3.9A)
 0.88A 3gp0A-4rt7A:
22.6		 3gp0A-4rt7A:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
ALA B 157
LEU B 167
ASP B 168
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 1.08A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
HIS B 148
ALA B 157
LEU B 167
 39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.85A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		9 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
ALA B 157
LEU B 167
ASP B 168
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
 0.98A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		9 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
HIS B 148
ALA B 157
LEU B 167
 None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
 0.90A 3gp0A-4tyhB:
41.1		 3gp0A-4tyhB:
75.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 VAL A  22
ALA A  35
GLU A  52
THR A  81
HIS A 127
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
None
 1.15A 3gp0A-4ueuA:
21.8		 3gp0A-4ueuA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		6 ALA A 131
LEU A 417
LEU A 481
ILE A 485
ALA A 493
LEU A 410
 None
 1.09A 3gp0A-4x9eA:
undetectable		 3gp0A-4x9eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.80A 3gp0A-4xufA:
22.0		 3gp0A-4xufA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
GLU A 509
LEU A 513
ILE A 522
THR A 539
HIS A 586
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
None
 0.64A 3gp0A-4yffA:
20.6		 3gp0A-4yffA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 ALA A  55
GLU A  76
LEU A  80
THR A 105
HIS A 149
ASP A 172
 ADP  A 506 (-3.3A)
None
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 ( 2.4A)
 1.25A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 VAL A  42
ALA A  55
GLU A  76
LEU A  79
LEU A  80
THR A 105
HIS A 149
 ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
None
None
None
ADP  A 506 ( 4.6A)
None
 0.78A 3gp0A-4ysjA:
23.4		 3gp0A-4ysjA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 VAL A 586
ALA A 597
GLU A 612
LEU A 615
LEU A 616
ILE A 626
HIS A 686
 None
 0.97A 3gp0A-4z7gA:
18.8		 3gp0A-4z7gA:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 738
ALA A 756
GLU A 775
LEU A 779
ILE A 788
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
None
None
None
 1.10A 3gp0A-5fm2A:
21.3		 3gp0A-5fm2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
GLU A 644
THR A 674
HIS A 816
ASP A 836
PHE A 837
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.83A 3gp0A-5grnA:
11.2		 3gp0A-5grnA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
LEU A  69
LEU A  70
ILE A  79
HIS A 149
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
 0.95A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
LEU A  70
ILE A  79
HIS A 149
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
FMT  A 403 ( 3.3A)
 1.15A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 647
ALA A 663
ILE A 695
THR A 711
HIS A 756
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
DIO  A1002 (-4.1A)
None
 0.62A 3gp0A-5l6oA:
22.1		 3gp0A-5l6oA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
ALA A 176
GLU A 193
LEU A 197
ILE A 212
HIS A 273
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.8A)
None
 0.88A 3gp0A-5lxdA:
25.8		 3gp0A-5lxdA:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 106
ALA A 119
GLU A 136
LEU A 139
LEU A 140
HIS A 223
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
None
 0.99A 3gp0A-5myvA:
20.9		 3gp0A-5myvA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 VAL A  52
ALA A  65
GLU A  89
LEU A  92
LEU A  93
ILE A 104
 7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
 0.65A 3gp0A-5turA:
21.5		 3gp0A-5turA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A  94
ALA A 107
GLU A 124
LEU A 127
LEU A 128
HIS A 211
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
None
 0.87A 3gp0A-5xv7A:
25.4		 3gp0A-5xv7A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  57
ALA A  70
GLU A  85
LEU A  89
ILE A  99
HIS A 158
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.4A)
None
None
ATP  A 403 (-4.9A)
None
 0.55A 3gp0A-5xvuA:
25.8		 3gp0A-5xvuA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 VAL A 701
ALA A 715
GLU A 732
LEU A 736
HIS A 813
ASP A 834
 919  A1101 (-4.7A)
919  A1101 (-3.5A)
919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
 0.70A 3gp0A-6cnhA:
26.9		 3gp0A-6cnhA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 VAL A 177
ALA A 191
GLU A 208
LEU A 212
HIS A 288
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
3NG  A 501 (-4.5A)
 1.08A 3gp0A-6fylA:
25.8		 3gp0A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 ARG A 134
VAL A 278
LEU A 292
ILE A 302
 None
 0.80A 3gp0A-1a2oA:
undetectable		 3gp0A-1a2oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		4 ARG A 146
VAL A 174
LEU A 342
ILE A 161
 None
 0.95A 3gp0A-1b25A:
undetectable		 3gp0A-1b25A:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ARG A  70
VAL A  86
LEU A 107
MET A 112
ILE A 169
 None
 0.75A 3gp0A-1cm8A:
37.8		 3gp0A-1cm8A:
63.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		4 VAL C 372
LEU C 254
LEU C 246
ILE C 230
 None
 0.96A 3gp0A-1d7wC:
undetectable		 3gp0A-1d7wC:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do5 HUMAN COPPER
CHAPERONE FOR
SUPEROXIDE DISMUTASE
DOMAIN II

(Homo sapiens) 		PF00080
(Sod_Cu) 		4 VAL A 102
LEU A 106
LEU A 168
ILE A  92
 None
 0.95A 3gp0A-1do5A:
undetectable		 3gp0A-1do5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 LYS A  28
LEU A  30
LEU A  23
ILE A  71
 None
 0.97A 3gp0A-1gwcA:
undetectable		 3gp0A-1gwcA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 LYS A  85
VAL A 277
LEU A 287
ILE A 276
 None
 0.96A 3gp0A-1l2qA:
undetectable		 3gp0A-1l2qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 608
LEU A 652
MET A 657
ILE A 740
 None
 0.94A 3gp0A-1lufA:
23.1		 3gp0A-1lufA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rx0 ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 8,
MITOCHONDRIAL

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 132
VAL A 181
MET A 110
ILE A 196
 None
 0.90A 3gp0A-1rx0A:
undetectable		 3gp0A-1rx0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9a CHLOROCATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ARG A 165
VAL A 151
LEU A 147
ILE A 123
 None
 0.95A 3gp0A-1s9aA:
undetectable		 3gp0A-1s9aA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 LEU B 270
LEU B  43
MET B  42
ILE B 218
 None
 0.81A 3gp0A-1t3qB:
undetectable		 3gp0A-1t3qB:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjn SIROHYDROCHLORIN
COBALTOCHELATASE

(Archaeoglobus
fulgidus) 		PF01903
(CbiX) 		4 ARG A   2
VAL A  65
LEU A  82
ILE A   7
 None
 0.88A 3gp0A-1tjnA:
undetectable		 3gp0A-1tjnA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		4 ARG A 313
VAL A 238
LEU A 164
ILE A 227
 None
 0.99A 3gp0A-1tt4A:
undetectable		 3gp0A-1tt4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcw PROTEASE DEGS

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 VAL A 154
LEU A 212
MET A 213
ILE A 172
 None
 0.87A 3gp0A-1vcwA:
undetectable		 3gp0A-1vcwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		4 VAL A 347
LEU A 214
LEU A 359
ILE A 346
 None
 0.94A 3gp0A-1ygpA:
undetectable		 3gp0A-1ygpA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 ARG A  33
VAL A  72
LEU A 128
ILE A  25
 None
 0.96A 3gp0A-1yp4A:
undetectable		 3gp0A-1yp4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqe HYPOTHETICAL UPF0204
PROTEIN AF0625

(Archaeoglobus
fulgidus) 		PF04414
(tRNA_deacylase) 		4 VAL A   5
LEU A 174
MET A 173
ILE A  70
 None
 1.00A 3gp0A-1yqeA:
undetectable		 3gp0A-1yqeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 ARG A 182
VAL A 214
LEU A 226
ILE A 163
 None
 0.94A 3gp0A-1z48A:
undetectable		 3gp0A-1z48A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7c CHORIONIC
SOMATOMAMMOTROPIN
HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 ARG A  91
VAL A 173
LEU A  23
LEU A  15
MET A  14
 None
 1.44A 3gp0A-1z7cA:
undetectable		 3gp0A-1z7cA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  42
VAL A  76
LEU A  91
LEU A  95
 None
 0.81A 3gp0A-1zwsA:
22.6		 3gp0A-1zwsA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 113
VAL A 142
MET A 162
ILE A 224
 None
 0.88A 3gp0A-2ac5A:
20.5		 3gp0A-2ac5A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 142
LEU A 157
MET A 162
ILE A 224
 None
 0.73A 3gp0A-2ac5A:
20.5		 3gp0A-2ac5A:
28.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 144
LEU A 148
MET A 149
ILE A 205
 AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
None
 0.76A 3gp0A-2b1pA:
35.7		 3gp0A-2b1pA:
48.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  93
LEU A 144
LEU A 148
ILE A 205
 AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 ( 4.7A)
None
 0.94A 3gp0A-2b1pA:
35.7		 3gp0A-2b1pA:
48.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3b GLUCOSE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF01547
(SBP_bac_1) 		4 ARG A 210
VAL A 363
LEU A 172
ILE A 366
 None
 0.97A 3gp0A-2b3bA:
undetectable		 3gp0A-2b3bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A 152
VAL A  44
LEU A 328
ILE A  43
 None
 0.86A 3gp0A-2bi0A:
undetectable		 3gp0A-2bi0A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2br4 CEPHALOSPORIN
HYDROXYLASE CMCI

(Streptomyces
clavuligerus) 		PF04989
(CmcI) 		4 ARG A  81
VAL A 228
MET A 169
ILE A 184
 None
 0.94A 3gp0A-2br4A:
undetectable		 3gp0A-2br4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bru NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA

(Escherichia
coli) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 ARG A1009
VAL A1360
LEU A1331
ILE A1361
 None
 0.91A 3gp0A-2bruA:
undetectable		 3gp0A-2bruA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ARG A   8
VAL A 182
LEU A 161
LEU A 164
 None
 0.92A 3gp0A-2dc0A:
undetectable		 3gp0A-2dc0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 194
LEU A 216
LEU A 221
ILE A 170
 None
 0.89A 3gp0A-2ejvA:
undetectable		 3gp0A-2ejvA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 VAL A 637
LEU A 773
MET A 616
ILE A 609
 None
 0.98A 3gp0A-2eyqA:
undetectable		 3gp0A-2eyqA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 VAL A 118
LEU A 122
LEU A 128
ILE A 269
 COA  A 800 (-3.9A)
EPE  A5000 (-4.1A)
None
None
 0.71A 3gp0A-2gq3A:
undetectable		 3gp0A-2gq3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		4 LYS A   3
ARG A  43
VAL A   8
ILE A  51
 None
 0.95A 3gp0A-2himA:
undetectable		 3gp0A-2himA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  78
ARG A  90
LEU A 122
ILE A 189
 None
 0.81A 3gp0A-2hw6A:
20.6		 3gp0A-2hw6A:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  52
LEU A  96
LEU A 100
ILE A  81
 None
None
QPP  A1314 (-4.5A)
None
 0.91A 3gp0A-2jc6A:
20.2		 3gp0A-2jc6A:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  52
LEU A  96
LEU A 100
ILE A 163
 None
None
QPP  A1314 (-4.5A)
None
 0.60A 3gp0A-2jc6A:
20.2		 3gp0A-2jc6A:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0h DNA PACKAGING
PROTEIN GP17

(Escherichia
virus T4) 		PF03237
(Terminase_6) 		4 VAL A 157
LEU A 164
LEU A 147
ILE A 284
 None
 0.91A 3gp0A-2o0hA:
undetectable		 3gp0A-2o0hA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxc PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX20

(Homo sapiens) 		PF00270
(DEAD) 		4 ARG A 140
LEU A 240
MET A 239
ILE A 229
 None
 0.99A 3gp0A-2oxcA:
undetectable		 3gp0A-2oxcA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 LYS A  48
LEU A 101
LEU A 105
MET A 106
ILE A  86
 ATP  A 381 (-3.2A)
None
None
None
None
 1.45A 3gp0A-2phkA:
22.8		 3gp0A-2phkA:
30.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyb NEUTROPHIL
ACTIVATING PROTEIN

(Borreliella
burgdorferi) 		PF00210
(Ferritin) 		5 ARG A  72
LEU A  24
LEU A 146
MET A 143
ILE A 127
 None
 1.38A 3gp0A-2pybA:
undetectable		 3gp0A-2pybA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1y CELL DIVISION
PROTEIN FTSZ

(Mycobacterium
tuberculosis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 ARG A  60
VAL A  14
MET A  27
ILE A  38
 None
 0.90A 3gp0A-2q1yA:
undetectable		 3gp0A-2q1yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3u PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		4 VAL A 154
LEU A 212
MET A 213
ILE A 172
 None
 0.86A 3gp0A-2r3uA:
undetectable		 3gp0A-2r3uA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 794
LEU A 798
MET A 799
ILE A 859
 GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
None
 0.55A 3gp0A-2r4bA:
20.6		 3gp0A-2r4bA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 751
LEU A 794
LEU A 798
ILE A 859
 GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
None
 0.80A 3gp0A-2r4bA:
20.6		 3gp0A-2r4bA:
26.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vws YFAU, 2-KETO-3-DEOXY
SUGAR ALDOLASE

(Escherichia
coli) 		PF03328
(HpcH_HpaI) 		4 VAL A 150
LEU A 180
LEU A 216
ILE A  96
 None
 0.97A 3gp0A-2vwsA:
undetectable		 3gp0A-2vwsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1t STAGE V SPORULATION
PROTEIN T

(Bacillus
subtilis) 		PF04014
(MazE_antitoxin)
PF15714
(SpoVT_C) 		4 ARG B 174
VAL B  74
LEU B  55
ILE B 150
 None
 0.99A 3gp0A-2w1tB:
undetectable		 3gp0A-2w1tB:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A  42
VAL A  76
LEU A  91
LEU A  95
ILE A 159
 ADP  A1303 (-2.7A)
None
None
None
None
 0.80A 3gp0A-2w4kA:
22.5		 3gp0A-2w4kA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 LYS A  53
LEU A 105
LEU A 109
MET A 110
ILE A  90
 None
None
B49  A1294 ( 4.7A)
None
None
 1.46A 3gp0A-2y7jA:
24.2		 3gp0A-2y7jA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1059
LEU A1078
MET A1079
ILE A1148
 None
S91  A   1 (-4.7A)
None
None
 0.69A 3gp0A-2z8cA:
22.3		 3gp0A-2z8cA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ARG A  95
VAL A  41
LEU A 121
LEU A  64
 None
 0.96A 3gp0A-2zwaA:
2.2		 3gp0A-2zwaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		4 ARG A  64
VAL A 441
LEU A 408
ILE A 440
 None
 0.92A 3gp0A-3ahrA:
undetectable		 3gp0A-3ahrA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpq TOXIN RELE3

(Methanocaldococcus
jannaschii) 		PF05016
(ParE_toxin) 		4 ARG B  23
VAL B   3
LEU B  13
ILE B  72
 None
 0.83A 3gp0A-3bpqB:
undetectable		 3gp0A-3bpqB:
14.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  54
VAL A  84
LEU A 105
ILE A 166
 None
 0.60A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  84
LEU A 105
MET A 110
ILE A 166
 None
 0.60A 3gp0A-3coiA:
36.5		 3gp0A-3coiA:
60.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  46
LEU A  90
LEU A  94
ILE A 162
 ANP  A   1 (-2.8A)
None
None
None
 0.91A 3gp0A-3dakA:
19.8		 3gp0A-3dakA:
29.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 106
LEU A 110
MET A 111
ILE A 167
 None
35F  A   1 (-4.5A)
None
None
 0.53A 3gp0A-3e7oA:
35.6		 3gp0A-3e7oA:
49.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e98 GAF DOMAIN OF
UNKNOWN FUNCTION

(Pseudomonas
aeruginosa) 		PF04340
(DUF484) 		4 ARG A 220
VAL A 119
LEU A 123
ILE A 194
 None
 0.97A 3gp0A-3e98A:
undetectable		 3gp0A-3e98A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 VAL A 323
LEU A 318
MET A 355
ILE A 314
 None
 0.93A 3gp0A-3eh7A:
undetectable		 3gp0A-3eh7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  39
LEU A  87
LEU A  91
ILE A  72
 ANP  A 329 (-2.7A)
None
ANP  A 329 ( 4.7A)
None
 0.85A 3gp0A-3hkoA:
22.4		 3gp0A-3hkoA:
29.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		4 ARG A  98
VAL A 113
LEU A 117
ILE A  87
 None
 0.84A 3gp0A-3ibyA:
undetectable		 3gp0A-3ibyA:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LYS A  42
LEU A  87
LEU A  91
ILE A  72
 None
 0.85A 3gp0A-3kl8A:
23.0		 3gp0A-3kl8A:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 220
VAL A 250
LEU A 267
MET A 272
ILE A 335
 None
 1.06A 3gp0A-3kmuA:
19.6		 3gp0A-3kmuA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 455
LEU A 496
LEU A 500
ILE A 481
 None
None
ANP  A 400 (-4.6A)
None
 0.97A 3gp0A-3kn5A:
18.1		 3gp0A-3kn5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 455
LEU A 496
LEU A 500
ILE A 563
 None
None
ANP  A 400 (-4.6A)
None
 0.91A 3gp0A-3kn5A:
18.1		 3gp0A-3kn5A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		4 LEU A 117
LEU A 248
MET A 245
ILE A  84
 None
 0.93A 3gp0A-3lgiA:
undetectable		 3gp0A-3lgiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgi PROTEASE DEGS

(Escherichia
coli) 		PF13365
(Trypsin_2) 		4 VAL A 154
LEU A 212
MET A 213
ILE A 172
 None
 0.87A 3gp0A-3lgiA:
undetectable		 3gp0A-3lgiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  62
VAL A  93
LEU A 108
ILE A 177
 QUE  A   1 (-4.1A)
None
None
None
 0.49A 3gp0A-3lm5A:
24.0		 3gp0A-3lm5A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A1033
VAL A1062
LEU A1081
ILE A1151
 CCX  A   1 ( 3.7A)
None
None
None
 0.94A 3gp0A-3lw0A:
22.8		 3gp0A-3lw0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A1062
LEU A1081
MET A1082
ILE A1151
 None
 0.68A 3gp0A-3lw0A:
22.8		 3gp0A-3lw0A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A  93
LEU A  17
MET A  18
ILE A  70
 None
 0.99A 3gp0A-3moiA:
undetectable		 3gp0A-3moiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 VAL A 496
LEU A 364
MET A 410
ILE A 499
 None
 0.95A 3gp0A-3ne5A:
undetectable		 3gp0A-3ne5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvt 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE SYNTHASE

(Listeria
monocytogenes) 		PF00793
(DAHP_synth_1)
PF01817
(CM_2) 		4 LYS A 231
ARG A 157
VAL A 185
ILE A 149
 ACT  A 363 (-2.3A)
None
None
None
 0.63A 3gp0A-3nvtA:
undetectable		 3gp0A-3nvtA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 VAL A 246
LEU A 261
LEU A 265
MET A 266
ILE A 327
 None
None
AMP  A 577 ( 4.9A)
None
None
 0.75A 3gp0A-3nyoA:
23.6		 3gp0A-3nyoA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		6 LYS A  54
VAL A  84
LEU A 105
LEU A 109
MET A 110
ILE A 167
 1N1  A1000 (-4.5A)
None
1N1  A1000 (-4.2A)
1N1  A1000 (-4.7A)
None
None
 0.82A 3gp0A-3ohtA:
18.9		 3gp0A-3ohtA:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		4 LEU A 110
LEU A 114
MET A 115
ILE A  90
 None
 0.97A 3gp0A-3pg1A:
34.1		 3gp0A-3pg1A:
38.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		4 LYS A  51
LEU A 114
MET A 115
ILE A  90
 None
 0.90A 3gp0A-3pg1A:
34.1		 3gp0A-3pg1A:
38.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pn1 DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		4 VAL A 171
LEU A 117
MET A  79
ILE A 228
 None
IVH  A 319 (-4.7A)
None
None
 0.90A 3gp0A-3pn1A:
undetectable		 3gp0A-3pn1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 753
VAL A 782
LEU A 796
LEU A 800
MET A 801
ILE A 861
 03Q  A   1 (-4.7A)
None
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
None
None
 0.85A 3gp0A-3pp0A:
21.2		 3gp0A-3pp0A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rac HISTIDINE-TRNA
LIGASE

(Alicyclobacillus
acidocaldarius) 		PF13393
(tRNA-synt_His) 		4 ARG A  93
LEU A 308
LEU A 314
ILE A 151
 None
 0.89A 3gp0A-3racA:
undetectable		 3gp0A-3racA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 ARG A 237
VAL A 203
LEU A 209
ILE A 232
 None
 0.93A 3gp0A-3snhA:
undetectable		 3gp0A-3snhA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sob LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 ARG B  77
LEU B  24
LEU B 232
ILE B 143
 None
 0.92A 3gp0A-3sobB:
undetectable		 3gp0A-3sobB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR4

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		4 ARG C 344
VAL C 108
LEU C  50
ILE C 315
 None
 0.92A 3gp0A-3x1lC:
undetectable		 3gp0A-3x1lC:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 VAL A 107
LEU A 112
MET A  85
ILE A  94
 None
 0.94A 3gp0A-4aurA:
undetectable		 3gp0A-4aurA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  84
LEU A 139
MET A 140
ILE A 198
 None
R4L  A1394 ( 4.9A)
None
None
 0.87A 3gp0A-4b99A:
37.6		 3gp0A-4b99A:
43.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bub UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--LD-LYSINE LIGASE

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 444
VAL A 370
LEU A 392
ILE A 450
 None
 0.97A 3gp0A-4bubA:
undetectable		 3gp0A-4bubA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0e NOT1

(Chaetomium
thermophilum) 		PF04054
(Not1) 		4 VAL A1766
LEU A1724
LEU A1711
ILE A1763
 None
 0.96A 3gp0A-4c0eA:
undetectable		 3gp0A-4c0eA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		4 VAL A 140
LEU A 294
LEU A 154
ILE A 137
 None
 0.89A 3gp0A-4cbwA:
undetectable		 3gp0A-4cbwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbw ACTIN, ALPHA
SKELETAL MUSCLE,
ACTIN

(Plasmodium
berghei;
synthetic
construct) 		PF00022
(Actin) 		4 VAL A 140
LEU A 294
LEU A 300
ILE A 137
 None
 0.96A 3gp0A-4cbwA:
undetectable		 3gp0A-4cbwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6y BACTERIAL
REGULATORY, FIS
FAMILY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg) 		4 LYS A  71
VAL A   7
LEU A  67
ILE A   5
 None
 1.00A 3gp0A-4d6yA:
undetectable		 3gp0A-4d6yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Mus musculus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 VAL A  78
LEU A 335
LEU A  88
ILE A  77
 None
 0.74A 3gp0A-4dklA:
undetectable		 3gp0A-4dklA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 VAL A 118
LEU A 122
LEU A 128
ILE A 270
 None
 0.82A 3gp0A-4ex4A:
undetectable		 3gp0A-4ex4A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		no annotation 4 LYS B 129
LEU B 126
LEU B 109
ILE B 166
 None
 0.90A 3gp0A-4f4zB:
undetectable		 3gp0A-4f4zB:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		4 ARG B 168
VAL B 145
LEU B 131
ILE B  74
 None
 0.77A 3gp0A-4f6tB:
undetectable		 3gp0A-4f6tB:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 VAL M 399
LEU M 298
LEU M 290
ILE M 400
 None
 0.94A 3gp0A-4heaM:
undetectable		 3gp0A-4heaM:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i34 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Escherichia
coli) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 ARG A 100
VAL A 310
LEU A 110
ILE A 115
 None
 0.70A 3gp0A-4i34A:
undetectable		 3gp0A-4i34A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		4 ARG A 261
LEU A 240
LEU A 193
ILE A 204
 None
 0.87A 3gp0A-4i7uA:
undetectable		 3gp0A-4i7uA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ARG A 219
VAL A 183
LEU A 224
ILE A 171
 None
 0.83A 3gp0A-4j0wA:
2.4		 3gp0A-4j0wA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		5 ARG A 181
VAL A 242
LEU A 133
LEU A 228
MET A 229
 None
 1.46A 3gp0A-4j7hA:
undetectable		 3gp0A-4j7hA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcd MAJOR CAPSID PROTEIN
VP1

(Human
polyomavirus 2) 		PF00718
(Polyoma_coat) 		4 ARG A  84
VAL A 287
LEU A 282
ILE A  99
 None
 0.96A 3gp0A-4jcdA:
undetectable		 3gp0A-4jcdA:
21.21