SIMILAR PATTERNS OF AMINO ACIDS FOR 3GN8_B_DEXB247
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pqw | POLYKETIDE SYNTHASE (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N) | 5 | LEU A 115ASN A 113GLY A 137VAL A 111PHE A 133 | None | 1.42A | 3gn8B-1pqwA:0.0 | 3gn8B-1pqwA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ued | P450 MONOOXYGENASE (Amycolatopsisorientalis) |
PF00067(p450) | 5 | LEU A 366GLY A 257TRP A 374VAL A 156PHE A 152 | None | 1.22A | 3gn8B-1uedA:2.8 | 3gn8B-1uedA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wch | PROTEIN TYROSINEPHOSPHATASE,NON-RECEPTOR TYPE 13 (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | GLY A2416MET A2308MET A2395VAL A2463PHE A2459 | None | 1.14A | 3gn8B-1wchA:0.0 | 3gn8B-1wchA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 324TRP A 361MET A 362ARG A 372VAL A 498 | None | 1.15A | 3gn8B-1xb7A:25.4 | 3gn8B-1xb7A:26.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zov | MONOMERIC SARCOSINEOXIDASE (Bacillus sp.NS-129) |
PF01266(DAO) | 5 | GLY A 263MET A 302THR A 87VAL A 146PHE A 259 | None | 1.30A | 3gn8B-1zovA:0.0 | 3gn8B-1zovA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 5 | LEU A 7ASN A 8GLY A 142GLN A 171THR A 92 | None | 1.50A | 3gn8B-2ajrA:0.0 | 3gn8B-2ajrA:20.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ax9 | ANDROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | GLY A 708GLN A 711MET A 742ARG A 752MET A 787 | BHM A 1 ( 3.8A)BHM A 1 (-2.2A)BHM A 1 ( 4.0A)BHM A 1 (-3.8A)BHM A 1 (-3.6A) | 0.89A | 3gn8B-2ax9A:32.8 | 3gn8B-2ax9A:53.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ax9 | ANDROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 8 | LEU A 704ASN A 705GLY A 708GLN A 711MET A 742ARG A 752VAL A 889PHE A 891 | BHM A 1 (-4.0A)BHM A 1 (-3.6A)BHM A 1 ( 3.8A)BHM A 1 (-2.2A)BHM A 1 ( 4.0A)BHM A 1 (-3.8A)NoneNone | 0.94A | 3gn8B-2ax9A:32.8 | 3gn8B-2ax9A:53.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2osy | ENDOGLYCOCERAMIDASEII (Rhodococcus sp.) |
PF00150(Cellulase) | 5 | LEU A 249GLY A 236GLN A 240VAL A 205PHE A 194 | None | 1.38A | 3gn8B-2osyA:0.0 | 3gn8B-2osyA:17.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 7 | ASN A 33GLY A 37TRP A 69CYH A 205THR A 208VAL A 217PHE A 219 | 1CA A 247 (-2.9A)NoneNone1CA A 247 (-4.0A)1CA A 247 (-3.4A)None1CA A 247 (-4.5A) | 0.94A | 3gn8B-2q3yA:36.9 | 3gn8B-2q3yA:76.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 10 | LEU A 32ASN A 33GLN A 39TRP A 69MET A 70ARG A 80CYH A 205THR A 208VAL A 217PHE A 219 | 1CA A 247 (-4.0A)1CA A 247 (-2.9A)1CA A 247 (-3.1A)None1CA A 247 ( 3.8A)1CA A 247 (-3.8A)1CA A 247 (-4.0A)1CA A 247 (-3.4A)None1CA A 247 (-4.5A) | 0.46A | 3gn8B-2q3yA:36.9 | 3gn8B-2q3yA:76.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 9 | LEU A 32ASN A 33GLN A 39TRP A 69MET A 70ARG A 80MET A 115CYH A 205PHE A 219 | 1CA A 247 (-4.0A)1CA A 247 (-2.9A)1CA A 247 (-3.1A)None1CA A 247 ( 3.8A)1CA A 247 (-3.8A)1CA A 247 ( 3.7A)1CA A 247 (-4.0A)1CA A 247 (-4.5A) | 0.73A | 3gn8B-2q3yA:36.9 | 3gn8B-2q3yA:76.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qt3 | N-ISOPROPYLAMMELIDEISOPROPYLAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF01979(Amidohydro_1) | 5 | LEU A 298ASN A 297GLY A 295THR A 246VAL A 350 | None | 1.39A | 3gn8B-2qt3A:undetectable | 3gn8B-2qt3A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 5 | LEU A1748ASN A1746GLY A1770VAL A1744PHE A1766 | None | 1.45A | 3gn8B-2vz9A:undetectable | 3gn8B-2vz9A:7.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x9p | PIMD PROTEIN (Streptomycesnatalensis) |
PF00067(p450) | 5 | LEU A 214ASN A 215GLY A 217ARG A 103VAL A 199 | None | 1.42A | 3gn8B-2x9pA:2.4 | 3gn8B-2x9pA:18.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcw | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8) | 5 | GLY A 352TRP A 428THR A 437VAL A 359PHE A 362 | None | 1.34A | 3gn8B-3gcwA:undetectable | 3gn8B-3gcwA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gri | DIHYDROOROTASE (Staphylococcusaureus) |
PF01979(Amidohydro_1) | 5 | LEU A 129GLY A 153GLN A 155MET A 159VAL A 96 | None CL A 600 ( 4.5A)NoneNoneNone | 1.45A | 3gn8B-3griA:undetectable | 3gn8B-3griA:20.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 8 | ASN A 719TRP A 755MET A 756MET A 801CYH A 891THR A 894VAL A 903PHE A 905 | WOW A 1 (-3.3A)NoneWOW A 1 ( 4.1A)WOW A 1 (-4.2A)WOW A 1 (-3.5A)WOW A 1 (-3.9A)NoneWOW A 1 (-4.6A) | 1.21A | 3gn8B-3kbaA:35.4 | 3gn8B-3kbaA:58.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | GLY A 722GLN A 725MET A 756ARG A 766MET A 801CYH A 891 | WOW A 1 ( 4.3A)WOW A 1 ( 4.1A)WOW A 1 ( 4.1A)WOW A 1 (-3.8A)WOW A 1 (-4.2A)WOW A 1 (-3.5A) | 0.93A | 3gn8B-3kbaA:35.4 | 3gn8B-3kbaA:58.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 10 | LEU A 718ASN A 719GLY A 722MET A 756ARG A 766MET A 801CYH A 891THR A 894VAL A 903PHE A 905 | WOW A 1 (-4.2A)WOW A 1 (-3.3A)WOW A 1 ( 4.3A)WOW A 1 ( 4.1A)WOW A 1 (-3.8A)WOW A 1 (-4.2A)WOW A 1 (-3.5A)WOW A 1 (-3.9A)NoneWOW A 1 (-4.6A) | 0.78A | 3gn8B-3kbaA:35.4 | 3gn8B-3kbaA:58.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0o | MONOMERIC SARCOSINEOXIDASE (Bacillus sp.B-0618) |
PF01266(DAO) | 5 | GLY A 263MET A 302THR A 87VAL A 146PHE A 259 | None | 1.35A | 3gn8B-3m0oA:undetectable | 3gn8B-3m0oA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nm1 | THIAMINEBIOSYNTHETICBIFUNCTIONAL ENZYME ([Candida]glabrata) |
PF02110(HK)PF02581(TMP-TENI) | 5 | LEU A 485ASN A 484GLY A 483ARG A 335THR A 248 | None | 1.33A | 3gn8B-3nm1A:undetectable | 3gn8B-3nm1A:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nxp | PRETHROMBIN-1 (Homo sapiens) |
PF00051(Kringle)PF00089(Trypsin)PF09396(Thrombin_light) | 5 | LEU A 560ASN A 559GLY A 536TRP A 607VAL A 417 | None | 1.50A | 3gn8B-3nxpA:undetectable | 3gn8B-3nxpA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3h | HMW1C-LIKEGLYCOSYLTRANSFERASE (Actinobacilluspleuropneumoniae) |
no annotation | 5 | GLY A 41GLN A 43TRP A 97THR A 439VAL A 478 | None | 1.49A | 3gn8B-3q3hA:undetectable | 3gn8B-3q3hA:18.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 8 | ASN A 33GLY A 37TRP A 69MET A 70CYH A 205THR A 208VAL A 217PHE A 219 | 1CA A 249 (-3.0A)NoneNone1CA A 249 ( 3.8A)1CA A 249 (-4.0A)1CA A 249 (-3.2A)1CA A 249 (-4.9A)1CA A 249 (-4.3A) | 0.88A | 3gn8B-3ry9A:36.2 | 3gn8B-3ry9A:84.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 11 | LEU A 32ASN A 33GLY A 36GLN A 39TRP A 69MET A 70ARG A 80CYH A 205THR A 208VAL A 217PHE A 219 | 1CA A 249 (-3.9A)1CA A 249 (-3.0A)1CA A 249 ( 4.0A)1CA A 249 (-3.0A)None1CA A 249 ( 3.8A)1CA A 249 (-3.5A)1CA A 249 (-4.0A)1CA A 249 (-3.2A)1CA A 249 (-4.9A)1CA A 249 (-4.3A) | 0.42A | 3gn8B-3ry9A:36.2 | 3gn8B-3ry9A:84.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 11 | LEU A 32ASN A 33GLY A 36GLN A 39TRP A 69MET A 70ARG A 80MET A 115CYH A 205THR A 208PHE A 219 | 1CA A 249 (-3.9A)1CA A 249 (-3.0A)1CA A 249 ( 4.0A)1CA A 249 (-3.0A)None1CA A 249 ( 3.8A)1CA A 249 (-3.5A)1CA A 249 (-3.6A)1CA A 249 (-4.0A)1CA A 249 (-3.2A)1CA A 249 (-4.3A) | 0.75A | 3gn8B-3ry9A:36.2 | 3gn8B-3ry9A:84.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dxo | LEA X(6) GFP-LIKEPROTEINS (syntheticconstruct) |
PF01353(GFP) | 5 | GLY A 20MET A 14CYH A 101VAL A 131PHE A 125 | None | 1.44A | 3gn8B-4dxoA:undetectable | 3gn8B-4dxoA:23.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 6 | LEU A 283TRP A 320MET A 321ARG A 331VAL A 460PHE A 462 | None | 0.80A | 3gn8B-4n1yA:27.7 | 3gn8B-4n1yA:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oy4 | CHIMERA PROTEIN OFCALMODULIN, GPF-LIKEPROTEIN EOSFP, ANDMYOSIN LIGHT CHAINKINASE (Gallus gallus;Lobophylliahemprichii;Rattusnorvegicus) |
PF01353(GFP)PF13499(EF-hand_7) | 5 | GLY A 260MET A 254CYH A 341VAL A 371PHE A 365 | None | 1.50A | 3gn8B-4oy4A:undetectable | 3gn8B-4oy4A:17.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | ASN A 564GLY A 568GLN A 570TRP A 600MET A 601CYH A 736PHE A 749 | MOF A 801 (-3.0A)NoneMOF A 801 (-2.9A)NoneMOF A 801 (-3.7A)MOF A 801 (-3.7A)MOF A 801 (-4.4A) | 1.08A | 3gn8B-4p6wA:39.0 | 3gn8B-4p6wA:76.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | LEU A 563ASN A 564GLY A 567GLN A 570TRP A 600MET A 601ARG A 611MET A 646CYH A 736THR A 739PHE A 749 | MOF A 801 (-3.9A)MOF A 801 (-3.0A)MOF A 801 (-3.4A)MOF A 801 (-2.9A)NoneMOF A 801 (-3.7A)MOF A 801 (-4.2A)MOF A 801 (-4.4A)MOF A 801 (-3.7A)MOF A 801 (-3.9A)MOF A 801 (-4.4A) | 0.45A | 3gn8B-4p6wA:39.0 | 3gn8B-4p6wA:76.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q60 | PROLINE RACEMASE (Burkholderiamultivorans) |
PF05544(Pro_racemase) | 5 | ASN A 134GLY A 161CYH A 89THR A 93VAL A 132 | PYC A 402 (-4.2A)NoneNoneNoneNone | 1.31A | 3gn8B-4q60A:undetectable | 3gn8B-4q60A:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qjy | GH127BETA-L-ARABINOFURANOSIDASE (Geobacillusstearothermophilus) |
PF07944(Glyco_hydro_127) | 5 | GLY A 549GLN A 547ARG A 356THR A 455VAL A 463 | None | 1.43A | 3gn8B-4qjyA:undetectable | 3gn8B-4qjyA:16.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | ASN A 770GLY A 774GLN A 776TRP A 806THR A 945VAL A 954PHE A 956 | CV7 A1987 (-3.1A)NoneCV7 A1987 (-3.0A)NoneCV7 A1987 (-3.1A)NoneCV7 A1987 ( 4.7A) | 1.15A | 3gn8B-4udbA:35.4 | 3gn8B-4udbA:57.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | LEU A 769ASN A 770GLN A 776TRP A 806MET A 807ARG A 817MET A 852CYH A 942THR A 945VAL A 954PHE A 956 | CV7 A1987 (-4.1A)CV7 A1987 (-3.1A)CV7 A1987 (-3.0A)NoneCV7 A1987 ( 3.9A)CV7 A1987 (-3.7A)CV7 A1987 ( 3.7A)CV7 A1987 (-4.0A)CV7 A1987 (-3.1A)NoneCV7 A1987 ( 4.7A) | 0.61A | 3gn8B-4udbA:35.4 | 3gn8B-4udbA:57.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wr2 | PYRIMIDINE-SPECIFICRIBONUCLEOSIDEHYDROLASE RIHA (Shewanellaloihica) |
PF01156(IU_nuc_hydro) | 5 | GLY A 344GLN A 343ARG A 250CYH A 289PHE A 300 | None | 1.49A | 3gn8B-4wr2A:undetectable | 3gn8B-4wr2A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xa9 | GALA PROTEIN TYPE 1,3 OR 4 (Legionellapneumophila) |
PF13516(LRR_6) | 5 | LEU A 19CYH A 35THR A 66VAL A 68PHE A 62 | None | 1.46A | 3gn8B-4xa9A:undetectable | 3gn8B-4xa9A:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4za2 | 2-DEOXY-D-GLUCONATE3-DEHYDROGENASE (Pectobacteriumcarotovorum) |
PF13561(adh_short_C2) | 5 | LEU A 30CYH A 18THR A 48VAL A 52PHE A 59 | None | 1.23A | 3gn8B-4za2A:undetectable | 3gn8B-4za2A:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dp1 | CURK (Mooreaproducens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 227ASN A 225GLY A 249VAL A 223PHE A 245 | None | 1.40A | 3gn8B-5dp1A:undetectable | 3gn8B-5dp1A:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex6 | CYTOCHROME P450 (Streptomycestoyocaensis) |
no annotation | 5 | LEU C 88ASN C 87GLY C 86ARG C 98THR C 287 | HEM C 502 (-3.7A)NoneNoneNoneHEM C 502 (-3.5A) | 1.42A | 3gn8B-5ex6C:undetectable | 3gn8B-5ex6C:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exc | GREEN FLUORESCENTPROTEIN (Dendronephthyasp. SSAL-2002) |
PF01353(GFP) | 5 | GLY A 20MET A 14CYH I 101VAL I 131PHE I 125 | NoneNLW A 61 ( 3.8A)NoneNoneNone | 1.45A | 3gn8B-5excA:undetectable | 3gn8B-5excA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m60 | BETA-1,3-GLUCANASE (Chaetomiumthermophilum) |
PF12708(Pectate_lyase_3) | 5 | LEU A 474GLY A 513GLN A 549VAL A 490PHE A 481 | None | 1.35A | 3gn8B-5m60A:undetectable | 3gn8B-5m60A:15.02 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 8 | ASN A 770GLY A 774GLN A 776TRP A 806CYH A 942THR A 945VAL A 954PHE A 956 | ECV A1101 (-3.1A)NoneECV A1101 (-2.9A)NoneECV A1101 (-4.0A)ECV A1101 (-3.2A)NoneECV A1101 ( 4.7A) | 1.07A | 3gn8B-5mwpA:35.9 | 3gn8B-5mwpA:42.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 5 | GLN A 776TRP A 806MET A 807ARG A 817MET A 852 | ECV A1101 (-2.9A)NoneECV A1101 (-3.6A)ECV A1101 (-4.0A)ECV A1101 (-3.7A) | 1.21A | 3gn8B-5mwpA:35.9 | 3gn8B-5mwpA:42.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 10 | LEU A 769ASN A 770GLN A 776TRP A 806MET A 807ARG A 817CYH A 942THR A 945VAL A 954PHE A 956 | ECV A1101 (-4.7A)ECV A1101 (-3.1A)ECV A1101 (-2.9A)NoneECV A1101 (-3.6A)ECV A1101 (-4.0A)ECV A1101 (-4.0A)ECV A1101 (-3.2A)NoneECV A1101 ( 4.7A) | 0.40A | 3gn8B-5mwpA:35.9 | 3gn8B-5mwpA:42.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 298TRP A 335MET A 336ARG A 346VAL A 485 | EST A 601 (-4.1A)NoneEST A 601 ( 3.7A)EST A 601 (-4.1A)None | 0.70A | 3gn8B-5toaA:25.0 | 3gn8B-5toaA:30.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uao | TRYPTOPHANE-5-HALOGENASE (Microbisporasp. ATCCPTA-5024) |
PF04820(Trp_halogenase) | 5 | LEU A 46GLY A 87ARG A 191VAL A 366PHE A 81 | None | 1.39A | 3gn8B-5uaoA:undetectable | 3gn8B-5uaoA:16.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uc1 | GLUCOCORTICOIDRECEPTOR (Heterocephalusglaber) |
no annotation | 6 | GLY A 563GLN A 566TRP A 596MET A 597ARG A 607MET A 642 | 486 A 801 (-3.7A)486 A 801 (-2.8A)NoneCPS A 803 ( 3.9A)486 A 801 (-3.5A)486 A 801 ( 3.8A) | 0.74A | 3gn8B-5uc1A:25.6 | 3gn8B-5uc1A:76.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5uc1 | GLUCOCORTICOIDRECEPTOR (Heterocephalusglaber) |
no annotation | 7 | LEU A 559ASN A 560GLY A 563GLN A 566MET A 597ARG A 607MET A 642 | 486 A 801 (-4.7A)486 A 801 (-4.2A)486 A 801 (-3.7A)486 A 801 (-2.8A)CPS A 803 ( 3.9A)486 A 801 (-3.5A)486 A 801 ( 3.8A) | 0.92A | 3gn8B-5uc1A:25.6 | 3gn8B-5uc1A:76.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 9 | ASN A 33GLY A 37GLN A 39TRP A 69MET A 70CYH A 205THR A 208VAL A 216PHE A 218 | 1TA A 301 (-3.0A)None1TA A 301 (-3.0A)None1TA A 301 ( 3.1A)1TA A 301 (-3.6A)1TA A 301 (-3.0A)1TA A 301 (-4.3A)1TA A 301 (-4.0A) | 0.92A | 3gn8B-5ufsA:40.5 | 3gn8B-5ufsA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 12 | LEU A 32ASN A 33GLY A 36GLN A 39TRP A 69MET A 70ARG A 80MET A 115CYH A 205THR A 208VAL A 216PHE A 218 | 1TA A 301 (-3.5A)1TA A 301 (-3.0A)1TA A 301 (-2.9A)1TA A 301 (-3.0A)None1TA A 301 ( 3.1A)1TA A 301 (-3.5A)1TA A 301 ( 2.8A)1TA A 301 (-3.6A)1TA A 301 (-3.0A)1TA A 301 (-4.3A)1TA A 301 (-4.0A) | 0.43A | 3gn8B-5ufsA:40.5 | 3gn8B-5ufsA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fsh | OXYB PROTEIN (Actinoplanesteichomyceticus) |
no annotation | 5 | LEU A 88ASN A 87GLY A 86ARG A 98THR A 287 | HEM A 401 (-3.3A)NoneNoneNoneHEM A 401 (-3.8A) | 1.36A | 3gn8B-6fshA:undetectable | 3gn8B-6fshA:19.32 |