SIMILAR PATTERNS OF AMINO ACIDS FOR 3GN8_A_DEXA247_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9b HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN YDIB

(Escherichia
coli) 		PF08501
(Shikimate_dh_N) 		5 ASN A 105
GLN A 266
MET A 258
THR A 137
VAL A  88
 None
None
NAI  A 301 (-3.9A)
None
None
 1.20A 3gn8A-1o9bA:
undetectable		 3gn8A-1o9bA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
TRP A 361
MET A 362
ARG A 372
VAL A 498
 None
 1.13A 3gn8A-1xb7A:
25.5		 3gn8A-1xb7A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.45A 3gn8A-2ajrA:
undetectable		 3gn8A-2ajrA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.92A 3gn8A-2ax9A:
32.8		 3gn8A-2ax9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
VAL A 889
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
None
 0.95A 3gn8A-2ax9A:
32.8		 3gn8A-2ax9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 704
ASN A 705
TRP A 741
MET A 742
VAL A 889
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
None
BHM  A   1 ( 4.0A)
None
 1.44A 3gn8A-2ax9A:
32.8		 3gn8A-2ax9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
GLY A 708
GLN A 711
MET A 742
ARG A 752
VAL A 889
 BHM  A   1 (-4.0A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
None
 0.92A 3gn8A-2ax9A:
32.8		 3gn8A-2ax9A:
53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 360
GLY A 363
GLN A 332
MET A 458
VAL A 378
 None
 1.24A 3gn8A-2d3tA:
undetectable		 3gn8A-2d3tA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljr GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 114
GLY A 111
GLN A  12
ARG A  15
VAL A 127
 None
 1.38A 3gn8A-2ljrA:
undetectable		 3gn8A-2ljrA:
19.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
TRP A  69
CYH A 205
THR A 208
VAL A 217
 1CA  A 247 (-2.9A)
None
None
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
None
 0.98A 3gn8A-2q3yA:
37.0		 3gn8A-2q3yA:
76.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
GLN A  39
TRP A  69
MET A  70
ARG A  80
CYH A 205
THR A 208
VAL A 217
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
None
 0.47A 3gn8A-2q3yA:
37.0		 3gn8A-2q3yA:
76.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
ASN A  33
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-4.0A)
1CA  A 247 (-3.4A)
 0.75A 3gn8A-2q3yA:
37.0		 3gn8A-2q3yA:
76.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 298
ASN A 297
GLY A 295
THR A 246
VAL A 350
 None
 1.43A 3gn8A-2qt3A:
undetectable		 3gn8A-2qt3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x9p PIMD PROTEIN

(Streptomyces
natalensis) 		PF00067
(p450) 		5 LEU A 214
ASN A 215
GLY A 217
ARG A 103
VAL A 199
 None
 1.46A 3gn8A-2x9pA:
undetectable		 3gn8A-2x9pA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 228
ASN A 227
GLY A 229
THR A 187
VAL A  36
 None
 1.27A 3gn8A-3hq9A:
undetectable		 3gn8A-3hq9A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A 228
ASN A 227
GLY A 230
THR A 187
VAL A  36
 None
 1.15A 3gn8A-3hq9A:
undetectable		 3gn8A-3hq9A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 719
TRP A 755
MET A 756
MET A 801
CYH A 891
THR A 894
VAL A 903
 WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
 1.23A 3gn8A-3kbaA:
35.6		 3gn8A-3kbaA:
58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
CYH A 891
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
 0.91A 3gn8A-3kbaA:
35.6		 3gn8A-3kbaA:
58.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
CYH A 891
THR A 894
VAL A 903
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.5A)
WOW  A   1 (-3.9A)
None
 0.79A 3gn8A-3kbaA:
35.6		 3gn8A-3kbaA:
58.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 240
ARG A 335
THR A 248
 None
 1.49A 3gn8A-3nm1A:
undetectable		 3gn8A-3nm1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 483
ARG A 335
THR A 248
 None
 1.34A 3gn8A-3nm1A:
undetectable		 3gn8A-3nm1A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 5 GLY A  41
GLN A  43
TRP A  97
THR A 439
VAL A 478
 None
 1.48A 3gn8A-3q3hA:
undetectable		 3gn8A-3q3hA:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
TRP A  69
CYH A 205
THR A 208
VAL A 217
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.92A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
CYH A 205
THR A 208
VAL A 217
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.43A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.78A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
TRP A 320
MET A 321
ARG A 331
VAL A 460
 None
 0.86A 3gn8A-4n1yA:
27.7		 3gn8A-4n1yA:
26.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 564
GLY A 568
TRP A 600
MET A 601
CYH A 736
THR A 739
 MOF  A 801 (-3.0A)
None
None
MOF  A 801 (-3.7A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.97A 3gn8A-4p6wA:
38.8		 3gn8A-4p6wA:
76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 563
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
CYH A 736
THR A 739
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
MOF  A 801 (-3.9A)
 0.43A 3gn8A-4p6wA:
38.8		 3gn8A-4p6wA:
76.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 TRP A 600
MET A 601
GLN A 642
MET A 646
CYH A 736
 None
MOF  A 801 (-3.7A)
None
MOF  A 801 (-4.4A)
MOF  A 801 (-3.7A)
 1.04A 3gn8A-4p6wA:
38.8		 3gn8A-4p6wA:
76.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		5 ASN A 134
GLY A 161
CYH A  89
THR A  93
VAL A 132
 PYC  A 402 (-4.2A)
None
None
None
None
 1.29A 3gn8A-4q60A:
undetectable		 3gn8A-4q60A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		5 GLY A 549
GLN A 547
ARG A 356
THR A 455
VAL A 463
 None
 1.44A 3gn8A-4qjyA:
undetectable		 3gn8A-4qjyA:
16.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
CYH A 942
THR A 945
VAL A 954
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-4.0A)
CV7  A1987 (-3.1A)
None
 0.63A 3gn8A-4udbA:
35.5		 3gn8A-4udbA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 LEU C  88
ASN C  87
GLY C  86
ARG C  98
THR C 287
 HEM  C 502 (-3.7A)
None
None
None
HEM  C 502 (-3.5A)
 1.44A 3gn8A-5ex6C:
2.4		 3gn8A-5ex6C:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ASN A 770
GLY A 774
GLN A 776
TRP A 806
CYH A 942
THR A 945
VAL A 954
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
 1.15A 3gn8A-5mwpA:
36.1		 3gn8A-5mwpA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.24A 3gn8A-5mwpA:
36.1		 3gn8A-5mwpA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 9 LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
CYH A 942
THR A 945
VAL A 954
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
None
 0.41A 3gn8A-5mwpA:
36.1		 3gn8A-5mwpA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
TRP A 335
MET A 336
ARG A 346
VAL A 485
 EST  A 601 (-4.1A)
None
EST  A 601 ( 3.7A)
EST  A 601 (-4.1A)
None
 0.67A 3gn8A-5toaA:
25.1		 3gn8A-5toaA:
30.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 GLY A 563
GLN A 566
TRP A 596
MET A 597
ARG A 607
MET A 642
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.72A 3gn8A-5uc1A:
25.7		 3gn8A-5uc1A:
76.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
GLY A 563
GLN A 566
ARG A 607
GLN A 638
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 0.91A 3gn8A-5uc1A:
25.7		 3gn8A-5uc1A:
76.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
ASN A 560
GLY A 563
GLN A 566
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.88A 3gn8A-5uc1A:
25.7		 3gn8A-5uc1A:
76.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 LEU A 559
GLY A 563
GLN A 566
MET A 597
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.80A 3gn8A-5uc1A:
25.7		 3gn8A-5uc1A:
76.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		7 ASN A  33
GLY A  37
TRP A  69
MET A  70
CYH A 205
THR A 208
VAL A 216
 1TA  A 301 (-3.0A)
None
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
 0.84A 3gn8A-5ufsA:
40.5		 3gn8A-5ufsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
VAL A 216
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.3A)
 0.44A 3gn8A-5ufsA:
40.5		 3gn8A-5ufsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 TRP A  69
MET A  70
ARG A  80
GLN A 111
MET A 115
CYH A 205
 None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.6A)
 1.37A 3gn8A-5ufsA:
40.5		 3gn8A-5ufsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.38A 3gn8A-6fshA:
undetectable		 3gn8A-6fshA:
19.32