SIMILAR PATTERNS OF AMINO ACIDS FOR 3GM0_A_B41A600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3go1	FAB 268-D, HEAVY CHAIN FAB 268-D, LIGHT CHAIN (Homo sapiens)	PF07654 (C1-set) PF07686 (V-set)	5	TYR H 33 TYR H 47 TYR H 50 TYR L 34 TYR L 36	None	0.87A	3gm0A-3go1H: 20.4	3gm0A-3go1H: 39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ddd	IMMUNOGENIC PROTEIN (Ehrlichia chaffeensis)	PF16868 (NMT1_3)	5	TYR A 237 SER A 93 TYR A 236 GLU A 124 TYR A 43	None None None None GOL A 405 (-3.8A)	1.31A	3gm0A-4dddA: 0.0	3gm0A-4dddA: 21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gqp	ANTI-METH SCFV (Mus musculus)	PF07686 (V-set)	11	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101 TYR H1034 TYR H1036 HIS H1089 TRP H1091 PHE H1096	B40 H1201 (-3.7A) B40 H1201 (-3.4A) B40 H1201 (-4.6A) B40 H1201 (-4.3A) B40 H1201 (-3.7A) B40 H1201 (-3.1A) B40 H1201 (-4.0A) None B40 H1201 (-4.1A) B40 H1201 (-3.9A) B40 H1201 ( 4.8A)	0.23A	3gm0A-4gqpH: 39.1	3gm0A-4gqpH: 99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4gqp	ANTI-METH SCFV (Mus musculus)	PF07686 (V-set)	8	TYR H 50 SER H 35 GLU H 101 TYR H1034 TYR H1036 HIS H1089 TRP H1091 PHE H1096	B40 H1201 (-4.3A) B40 H1201 (-3.4A) B40 H1201 (-3.1A) B40 H1201 (-4.0A) None B40 H1201 (-4.1A) B40 H1201 (-3.9A) B40 H1201 ( 4.8A)	1.23A	3gm0A-4gqpH: 39.1	3gm0A-4gqpH: 99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4jy4	PGT121 HEAVY CHAIN PGT121 LIGHT CHAIN (Homo sapiens)	PF07654 (C1-set) PF07686 (V-set)	5	TYR B 33 SER B 35 TYR B 50 TYR A 36 HIS A 89	None	1.16A	3gm0A-4jy4B: 17.4	3gm0A-4jy4B: 35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4laq	SINGLE HEAVY CHAIN VARIABLE FRAGMENT (Mus musculus)	PF07686 (V-set)	6	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101	None	0.68A	3gm0A-4laqH: 16.9	3gm0A-4laqH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	PF07686 (V-set)	5	SER H 93 PHE H 95 TYR L 34 HIS L 89 TRP L 91	None 1WE L 300 ( 4.1A) 1WE L 300 ( 4.8A) 1WE L 300 (-4.2A) 1WE L 300 (-4.1A)	1.07A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	PF07686 (V-set)	11	TYR H 33 SER H 35 TYR H 47 TYR H 50 PHE H 95 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 (-3.9A) 1WE L 300 (-3.6A) None 1WE L 300 ( 4.5A) 1WE L 300 ( 4.1A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	0.24A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4lar	SINGLE HEAVY CHAIN VARIABLE FRAGMENT SINGLE LIGHT CHAIN VARIABLE FRAGMENT (Mus musculus)	PF07686 (V-set)	8	TYR H 50 SER H 35 GLU H 101 TYR L 34 TYR L 36 HIS L 89 TRP L 91 PHE L 96	1WE L 300 ( 4.5A) 1WE L 300 (-3.6A) 1WE L 300 (-3.7A) 1WE L 300 ( 4.8A) None 1WE L 300 (-4.2A) 1WE L 300 (-4.1A) 1WE L 300 ( 4.7A)	1.21A	3gm0A-4larH: 24.2	3gm0A-4larH: 100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ck0	SUSD HOMOLOG (Bacteroides thetaiotaomicron)	PF07980 (SusD_RagB) PF14322 (SusD-like_3)	5	TYR A 352 SER A 353 TYR A 66 TYR A 371 PHE A 351	None	1.47A	3gm0A-5ck0A: undetectable	3gm0A-5ck0A: 16.40

[["3GM0_A_B41A600_1","3go1","Homo sapiens","FAB 268-D, HEAVY CHAIN;FAB 268-D, LIGHT CHAIN","PF07654(C1-set);PF07686(V-set)",5,"TYR H  33;TYR H  47;TYR H  50;TYR L  34;TYR L  36","None","0.87A","3gm0A-3go1H:20.4","3gm0A-3go1H:39.84"],["3GM0_A_B41A600_1","4ddd","Ehrlichia chaffeensis","IMMUNOGENIC PROTEIN","PF16868(NMT1_3)",5,"TYR A 237;SER A  93;TYR A 236;GLU A 124;TYR A  43","None;None;None;None;GOL A 405 (-3.8A)","1.31A","3gm0A-4dddA:0.0","3gm0A-4dddA:21.24"],["3GM0_A_B41A600_1","4gqp","Mus musculus","ANTI-METH SCFV","PF07686(V-set)",11,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101;TYR H1034;TYR H1036;HIS H1089;TRP H1091;PHE H1096","B40 H1201 (-3.7A);B40 H1201 (-3.4A);B40 H1201 (-4.6A);B40 H1201 (-4.3A);B40 H1201 (-3.7A);B40 H1201 (-3.1A);B40 H1201 (-4.0A);None;B40 H1201 (-4.1A);B40 H1201 (-3.9A);B40 H1201 ( 4.8A)","0.23A","3gm0A-4gqpH:39.1","3gm0A-4gqpH:99.60"],["3GM0_A_B41A600_1","4gqp","Mus musculus","ANTI-METH SCFV","PF07686(V-set)",8,"TYR H  50;SER H  35;GLU H 101;TYR H1034;TYR H1036;HIS H1089;TRP H1091;PHE H1096","B40 H1201 (-4.3A);B40 H1201 (-3.4A);B40 H1201 (-3.1A);B40 H1201 (-4.0A);None;B40 H1201 (-4.1A);B40 H1201 (-3.9A);B40 H1201 ( 4.8A)","1.23A","3gm0A-4gqpH:39.1","3gm0A-4gqpH:99.60"],["3GM0_A_B41A600_1","4jy4","Homo sapiens","PGT121 HEAVY CHAIN;PGT121 LIGHT CHAIN","PF07654(C1-set);PF07686(V-set)",5,"TYR B  33;SER B  35;TYR B  50;TYR A  36;HIS A  89","None","1.16A","3gm0A-4jy4B:17.4","3gm0A-4jy4B:35.02"],["3GM0_A_B41A600_1","4laq","Mus musculus","SINGLE HEAVY CHAIN VARIABLE  FRAGMENT","PF07686(V-set)",6,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101","None","0.68A","3gm0A-4laqH:16.9","3gm0A-4laqH:100.00"],["3GM0_A_B41A600_1","4lar","Mus musculus","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","PF07686(V-set)",5,"SER H  93;PHE H  95;TYR L  34;HIS L  89;TRP L  91","None;1WE L 300 ( 4.1A);1WE L 300 ( 4.8A);1WE L 300 (-4.2A);1WE L 300 (-4.1A)","1.07A","3gm0A-4larH:24.2","3gm0A-4larH:100.00"],["3GM0_A_B41A600_1","4lar","Mus musculus","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","PF07686(V-set)",11,"TYR H  33;SER H  35;TYR H  47;TYR H  50;PHE H  95;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 (-3.9A);1WE L 300 (-3.6A);None;1WE L 300 ( 4.5A);1WE L 300 ( 4.1A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","0.24A","3gm0A-4larH:24.2","3gm0A-4larH:100.00"],["3GM0_A_B41A600_1","4lar","Mus musculus","SINGLE HEAVY CHAIN VARIABLE FRAGMENT;SINGLE LIGHT CHAIN VARIABLE FRAGMENT","PF07686(V-set)",8,"TYR H  50;SER H  35;GLU H 101;TYR L  34;TYR L  36;HIS L  89;TRP L  91;PHE L  96","1WE L 300 ( 4.5A);1WE L 300 (-3.6A);1WE L 300 (-3.7A);1WE L 300 ( 4.8A);None;1WE L 300 (-4.2A);1WE L 300 (-4.1A);1WE L 300 ( 4.7A)","1.21A","3gm0A-4larH:24.2","3gm0A-4larH:100.00"],["3GM0_A_B41A600_1","5ck0","Bacteroides thetaiotaomicron","SUSD HOMOLOG","PF07980(SusD_RagB);PF14322(SusD-like_3)",5,"TYR A 352;SER A 353;TYR A  66;TYR A 371;PHE A 351","None","1.47A","3gm0A-5ck0A:undetectable","3gm0A-5ck0A:16.40"]]