SIMILAR PATTERNS OF AMINO ACIDS FOR 3GKZ_A_B40A500_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3go1 FAB 268-D, HEAVY
CHAIN
FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR H  33
TYR H  47
TYR H  50
TYR L  34
TYR L  36
 None
 0.83A 3gkzA-3go1H:
21.1		 3gkzA-3go1H:
39.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddd IMMUNOGENIC PROTEIN

(Ehrlichia
chaffeensis) 		PF16868
(NMT1_3) 		5 TYR A 237
SER A  93
TYR A 236
GLU A 124
TYR A  43
 None
None
None
None
GOL  A 405 (-3.8A)
 1.30A 3gkzA-4dddA:
undetectable		 3gkzA-4dddA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gqp ANTI-METH SCFV

(Mus musculus) 		PF07686
(V-set) 		11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
TYR H1034
TYR H1036
HIS H1089
TRP H1091
PHE H1096
 B40  H1201 (-3.7A)
B40  H1201 (-3.4A)
B40  H1201 (-4.6A)
B40  H1201 (-4.3A)
B40  H1201 (-3.7A)
B40  H1201 (-3.1A)
B40  H1201 (-4.0A)
None
B40  H1201 (-4.1A)
B40  H1201 (-3.9A)
B40  H1201 ( 4.8A)
 0.13A 3gkzA-4gqpH:
40.5		 3gkzA-4gqpH:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy4 PGT121 HEAVY CHAIN
PGT121 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.14A 3gkzA-4jy4B:
18.0		 3gkzA-4jy4B:
35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4jy6 PGT123 HEAVY CHAIN
PGT123 LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 TYR B  33
SER B  35
TYR B  50
TYR A  36
HIS A  89
 None
 1.16A 3gkzA-4jy6B:
17.0		 3gkzA-4jy6B:
33.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		6 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
 None
 0.67A 3gkzA-4laqH:
17.1		 3gkzA-4laqH:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		5 SER H  93
PHE H  95
TYR L  34
HIS L  89
TRP L  91
 None
1WE  L 300 ( 4.1A)
1WE  L 300 ( 4.8A)
1WE  L 300 (-4.2A)
1WE  L 300 (-4.1A)
 1.06A 3gkzA-4larH:
25.1		 3gkzA-4larH:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lar SINGLE HEAVY CHAIN
VARIABLE FRAGMENT
SINGLE LIGHT CHAIN
VARIABLE FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		11 TYR H  33
SER H  35
TYR H  47
TYR H  50
PHE H  95
GLU H 101
TYR L  34
TYR L  36
HIS L  89
TRP L  91
PHE L  96
 1WE  L 300 (-3.9A)
1WE  L 300 (-3.6A)
None
1WE  L 300 ( 4.5A)
1WE  L 300 ( 4.1A)
1WE  L 300 (-3.7A)
1WE  L 300 ( 4.8A)
None
1WE  L 300 (-4.2A)
1WE  L 300 (-4.1A)
1WE  L 300 ( 4.7A)
 0.19A 3gkzA-4larH:
25.1		 3gkzA-4larH:
100.00