SIMILAR PATTERNS OF AMINO ACIDS FOR 3GF2_A_SALA147_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0c SULFURTRANSFERASE

(Azotobacter
vinelandii) 		PF00581
(Rhodanese) 		4 TYR A  87
LEU A  27
ARG A  45
TYR A  36
 None
 1.37A 3gf2A-1e0cA:
undetectable		 3gf2A-1e0cA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		4 TYR A 246
LEU A  60
ARG A  63
TYR A 241
 None
None
GOL  A1295 (-3.3A)
None
 1.29A 3gf2A-1uzrA:
0.6		 3gf2A-1uzrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch2 SERINE-REPEAT
ANTIGEN PROTEIN

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		4 TYR X 798
LEU X 575
ARG X 574
TYR X 603
 None
 1.48A 3gf2A-3ch2X:
0.0		 3gf2A-3ch2X:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF13463
(HTH_27) 		4 TYR A  37
LEU A  41
ARG A  44
TYR A 111
 None
 0.14A 3gf2A-3gfmA:
24.2		 3gf2A-3gfmA:
99.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		4 TYR A  97
LEU A 151
ARG A 155
TYR A 158
 TYD  A 401 (-3.8A)
None
None
None
 1.17A 3gf2A-3hjnA:
0.0		 3gf2A-3hjnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4puc SUSD HOMOLOG

(Bacteroides
uniformis) 		PF12741
(SusD-like) 		4 TYR A 337
LEU A 321
ARG A 323
TYR A 409
 None
 1.33A 3gf2A-4pucA:
0.0		 3gf2A-4pucA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7l ELP3 FAMILY, ELP3
FAMILY

(Dehalococcoides
mccartyi) 		PF04055
(Radical_SAM)
PF16199
(Radical_SAM_C) 		4 TYR A 440
LEU A 383
ARG A 364
TYR A 190
 None
 1.46A 3gf2A-5l7lA:
0.0		 3gf2A-5l7lA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eot DIPEPTIDYL PEPTIDASE
8

(Homo sapiens) 		no annotation 4 TYR A 651
LEU A 689
ARG A 688
TYR A 630
 None
 1.43A 3gf2A-6eotA:
0.0		 3gf2A-6eotA:
21.55