SIMILAR PATTERNS OF AMINO ACIDS FOR 3GCS_A_BAXA401_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 MET A  81
VAL A  86
ILE A 149
ILE A 169
 None
 0.74A 3gcsA-1cm8A:
23.5		 3gcsA-1cm8A:
60.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 VAL A 423
LEU A 360
ILE A 273
ILE A 427
 None
 0.83A 3gcsA-1hr7A:
undetectable		 3gcsA-1hr7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc3 GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 VAL A 105
LEU A 195
ILE A  46
ILE A   5
 None
 0.93A 3gcsA-1mc3A:
undetectable		 3gcsA-1mc3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus) 		PF00149
(Metallophos) 		4 LEU A 172
MET A 171
ILE A  35
ILE A  44
 None
 0.95A 3gcsA-1s8eA:
undetectable		 3gcsA-1s8eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkf HYPOTHETICAL PROTEIN
RV2626C

(Mycobacterium
tuberculosis) 		PF00571
(CBS) 		5 MET A   8
VAL A 104
LEU A  49
MET A  48
ILE A 105
 None
 1.44A 3gcsA-1xkfA:
undetectable		 3gcsA-1xkfA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 VAL A  67
LEU A 139
ILE A 192
ILE A 165
 None
 0.92A 3gcsA-1z8wA:
undetectable		 3gcsA-1z8wA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		5 VAL A 255
LEU A  76
MET A  75
ILE A 310
ILE A 317
 None
 1.38A 3gcsA-2cy7A:
undetectable		 3gcsA-2cy7A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxf NUCLEOSIDE
DIPHOSPHATE KINASE

(Pyrococcus
horikoshii) 		PF00334
(NDK) 		4 MET A  79
VAL A  12
ILE A  28
ILE A 123
 None
 0.76A 3gcsA-2dxfA:
undetectable		 3gcsA-2dxfA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		4 MET A 173
VAL A 151
ILE A  47
ILE A 127
 None
 0.92A 3gcsA-2ekcA:
undetectable		 3gcsA-2ekcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A  10
LEU A  74
ILE A  48
ILE A  59
 None
 0.87A 3gcsA-2erxA:
undetectable		 3gcsA-2erxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf0 GTP-BINDING PROTEIN
DI-RAS1

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A  10
LEU A  74
ILE A  48
ILE A  59
 None
 0.80A 3gcsA-2gf0A:
undetectable		 3gcsA-2gf0A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		4 LEU A 182
MET A 181
ILE A  40
ILE A  66
 LEU  A 182 ( 0.6A)
GLY  A 106 ( 3.4A)
ILE  A  40 ( 0.7A)
ILE  A  66 ( 0.7A)
 0.96A 3gcsA-2hk0A:
undetectable		 3gcsA-2hk0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		5 MET A 153
VAL A 103
LEU A 108
ILE A 176
ILE A  58
 None
 1.34A 3gcsA-2it2A:
undetectable		 3gcsA-2it2A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 VAL A 134
LEU A 174
MET A 173
ILE A 103
 None
 0.96A 3gcsA-2oajA:
undetectable		 3gcsA-2oajA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 MET A 270
VAL A 268
LEU A  50
ILE A 278
ILE A 265
 None
 1.27A 3gcsA-2pqdA:
undetectable		 3gcsA-2pqdA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt6 LACCASE

(Lentinus
tigrinus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 466
VAL A 464
ILE A 381
ILE A 338
 None
 0.95A 3gcsA-2qt6A:
undetectable		 3gcsA-2qt6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		5 MET A 108
VAL A  94
LEU A  66
ILE A  73
ILE A  91
 None
 1.43A 3gcsA-2qz8A:
undetectable		 3gcsA-2qz8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6z UPF0341 PROTEIN IN
RSP 3' REGION

(Neisseria
gonorrhoeae) 		PF04445
(SAM_MT) 		4 VAL A  87
MET A 152
ILE A  75
ILE A 164
 None
 0.91A 3gcsA-2r6zA:
undetectable		 3gcsA-2r6zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt3 NEGATIVE REGULATOR
OF DIFFERENTIATION 1

(Schizosaccharomyces
pombe) 		PF00076
(RRM_1) 		4 VAL A 208
LEU A 283
ILE A 222
ILE A 272
 None
 0.90A 3gcsA-2rt3A:
undetectable		 3gcsA-2rt3A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 VAL A  18
LEU A 179
ILE A  57
ILE A  80
 None
 0.89A 3gcsA-2v25A:
undetectable		 3gcsA-2v25A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whl BETA-MANNANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		4 MET A  81
LEU A 218
ILE A  40
ILE A  25
 None
 0.90A 3gcsA-2whlA:
undetectable		 3gcsA-2whlA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 VAL A 317
LEU A 335
ILE A 301
ILE A 287
 None
 0.77A 3gcsA-2x4lA:
undetectable		 3gcsA-2x4lA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xkr PUTATIVE CYTOCHROME
P450 142

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 LEU A 303
MET A 280
ILE A 138
ILE A 229
 None
HEM  A1400 ( 4.4A)
None
PG4  A1399 ( 4.5A)
 0.95A 3gcsA-2xkrA:
undetectable		 3gcsA-2xkrA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 465
VAL A 463
ILE A 382
ILE A 339
 None
 0.96A 3gcsA-2xybA:
undetectable		 3gcsA-2xybA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 VAL A 773
LEU A 813
ILE A 837
ILE A 776
 None
 0.89A 3gcsA-2xzoA:
undetectable		 3gcsA-2xzoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y77 3-DEHYDROQUINATE
DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01220
(DHquinase_II) 		4 VAL A   7
LEU A  59
ILE A 130
ILE A  73
 None
 0.90A 3gcsA-2y77A:
undetectable		 3gcsA-2y77A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		4 LEU A 177
MET A 174
ILE A  68
ILE A  70
 None
 0.90A 3gcsA-2ygkA:
undetectable		 3gcsA-2ygkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 VAL A 347
LEU A 401
ILE A 370
ILE A 355
 None
 0.88A 3gcsA-3acpA:
undetectable		 3gcsA-3acpA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 VAL A 202
LEU A 129
ILE A 186
ILE A 143
 None
 0.77A 3gcsA-3b46A:
undetectable		 3gcsA-3b46A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bif PROTEIN
(6-PHOSPHOFRUCTO-2-K
INASE/
FRUCTOSE-2,6-BISPHOS
PHATASE)

(Rattus
norvegicus) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 VAL A 126
LEU A 107
ILE A  54
ILE A  41
 None
 0.91A 3gcsA-3bifA:
undetectable		 3gcsA-3bifA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2g SYS-1 PROTEIN

(Caenorhabditis
elegans) 		no annotation 4 VAL A 538
LEU A 588
ILE A 504
ILE A 541
 None
 0.88A 3gcsA-3c2gA:
undetectable		 3gcsA-3c2gA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 MET A 382
VAL A 385
ILE A 398
ILE A 389
 None
 0.90A 3gcsA-3d36A:
undetectable		 3gcsA-3d36A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A 124
MET A 115
ILE A 247
ILE A  82
 None
 0.97A 3gcsA-3enkA:
undetectable		 3gcsA-3enkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euc HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE 2

(Cupriavidus
pinatubonensis) 		PF00155
(Aminotran_1_2) 		4 VAL A 111
LEU A 149
ILE A  97
ILE A 159
 None
 0.87A 3gcsA-3eucA:
undetectable		 3gcsA-3eucA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4n PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Yersinia pestis) 		PF03740
(PdxJ) 		4 MET A 209
VAL A 189
ILE A 175
ILE A 152
 None
 0.85A 3gcsA-3f4nA:
undetectable		 3gcsA-3f4nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9t L-TYROSINE
DECARBOXYLASE MFNA

(Methanocaldococcus
jannaschii) 		PF00282
(Pyridoxal_deC) 		4 VAL A 374
LEU A 212
MET A 246
ILE A 378
 None
 0.83A 3gcsA-3f9tA:
undetectable		 3gcsA-3f9tA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 VAL A 336
LEU A 436
ILE A 395
ILE A 334
 None
 0.95A 3gcsA-3gcwA:
undetectable		 3gcsA-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4) 		PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C) 		4 VAL A  67
LEU A  48
ILE A 271
ILE A 122
 None
 0.91A 3gcsA-3h8wA:
undetectable		 3gcsA-3h8wA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 MET A 421
VAL A 449
LEU A 318
ILE A 468
 None
 0.87A 3gcsA-3higA:
undetectable		 3gcsA-3higA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jug BETA-MANNANASE

(Bacillus sp.
N16-5) 		PF00150
(Cellulase) 		4 MET A 112
LEU A 249
ILE A  71
ILE A  56
 None
 0.94A 3gcsA-3jugA:
undetectable		 3gcsA-3jugA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k28 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
2

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 MET A 114
VAL A 112
ILE A 270
ILE A 109
 None
None
None
CA  A 430 (-4.9A)
 0.90A 3gcsA-3k28A:
undetectable		 3gcsA-3k28A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 250
MET A 272
ILE A 315
ILE A 335
 None
 0.79A 3gcsA-3kmuA:
18.8		 3gcsA-3kmuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 MET A 865
VAL A 990
ILE A 849
ILE A 993
 None
 0.96A 3gcsA-3l4kA:
undetectable		 3gcsA-3l4kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 728
LEU A 747
ILE A 793
ILE A 826
 None
 0.75A 3gcsA-3lj0A:
19.2		 3gcsA-3lj0A:
27.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 VAL A  25
LEU A  40
ILE A 251
ILE A  29
 None
 0.94A 3gcsA-3mbhA:
undetectable		 3gcsA-3mbhA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpd NUCLEOSIDE
DIPHOSPHATE KINASE

(Encephalitozoon
cuniculi) 		PF00334
(NDK) 		4 MET A  73
MET A  65
ILE A  22
ILE A 114
 None
 0.86A 3gcsA-3mpdA:
undetectable		 3gcsA-3mpdA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		4 VAL A 274
LEU A 313
ILE A 256
ILE A 246
 None
 0.80A 3gcsA-3nxkA:
undetectable		 3gcsA-3nxkA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 MET A  79
VAL A  84
LEU A 109
MET A 110
ILE A 147
 None
None
1N1  A1000 (-4.7A)
None
None
 1.07A 3gcsA-3ohtA:
16.5		 3gcsA-3ohtA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		5 MET A  79
VAL A  84
MET A 110
ILE A 147
ILE A 167
 None
 0.84A 3gcsA-3ohtA:
16.5		 3gcsA-3ohtA:
83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oo9 ABC TRANSPORTER
BINDING PROTEIN ACBH

(Actinoplanes
sp. SE50/110) 		PF01547
(SBP_bac_1) 		4 MET A  38
VAL A  49
ILE A 311
ILE A  19
 None
 0.77A 3gcsA-3oo9A:
undetectable		 3gcsA-3oo9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  42
LEU A 349
ILE A  11
ILE A  43
 None
 0.94A 3gcsA-3pfrA:
undetectable		 3gcsA-3pfrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 774
VAL A 782
MET A 801
ILE A 861
 03Q  A   1 (-4.5A)
None
None
None
 0.87A 3gcsA-3pp0A:
19.0		 3gcsA-3pp0A:
27.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		4 MET A 143
VAL A 141
LEU A 292
ILE A 129
 None
 0.85A 3gcsA-3r8eA:
undetectable		 3gcsA-3r8eA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf2 30S RIBOSOMAL
PROTEIN S8

(Aquifex
aeolicus) 		PF00410
(Ribosomal_S8) 		4 VAL A  27
LEU A  80
ILE A  46
ILE A  94
 None
 0.96A 3gcsA-3rf2A:
undetectable		 3gcsA-3rf2A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		4 VAL A  88
LEU A 121
ILE A 212
ILE A 139
 None
 0.85A 3gcsA-3rkrA:
undetectable		 3gcsA-3rkrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 VAL A 249
LEU A 217
ILE A  63
ILE A 268
 None
 0.78A 3gcsA-3rl3A:
undetectable		 3gcsA-3rl3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		5 VAL A 108
LEU A 285
MET A 280
ILE A  88
ILE A  84
 None
 1.48A 3gcsA-3rotA:
undetectable		 3gcsA-3rotA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 VAL A 126
LEU A 314
ILE A  72
ILE A  32
 None
 0.95A 3gcsA-3wiqA:
undetectable		 3gcsA-3wiqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dry 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 VAL A  93
LEU A 126
ILE A 226
ILE A 146
 None
 0.96A 3gcsA-4dryA:
undetectable		 3gcsA-4dryA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A  17
LEU A 319
MET A 316
ILE A 176
 None
 0.92A 3gcsA-4ewpA:
undetectable		 3gcsA-4ewpA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT BETA

(Azotobacter
vinelandii) 		PF00696
(AA_kinase) 		4 VAL B 145
LEU B 131
ILE B  49
ILE B  74
 None
 0.94A 3gcsA-4f6tB:
undetectable		 3gcsA-4f6tB:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 VAL A 101
LEU A 319
MET A 315
ILE A  78
 None
 0.94A 3gcsA-4hy3A:
undetectable		 3gcsA-4hy3A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 464
VAL A 462
ILE A 325
ILE A 338
 None
 0.84A 3gcsA-4jhvA:
undetectable		 3gcsA-4jhvA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhv LACCASE

(Coriolopsis
caperata) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 MET A 464
VAL A 462
ILE A 381
ILE A 338
 None
 0.84A 3gcsA-4jhvA:
undetectable		 3gcsA-4jhvA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jro FABG PROTEIN

(Listeria
monocytogenes) 		PF13561
(adh_short_C2) 		4 VAL A  88
LEU A 120
ILE A 219
ILE A 138
 None
 0.95A 3gcsA-4jroA:
undetectable		 3gcsA-4jroA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 VAL A  50
LEU A 349
ILE A  31
ILE A 393
 VAL  A  50 ( 0.6A)
LEU  A 349 ( 0.5A)
ILE  A  31 ( 0.7A)
ILE  A 393 ( 0.4A)
 0.69A 3gcsA-4kqnA:
undetectable		 3gcsA-4kqnA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		4 LEU A 143
MET A 142
ILE A  85
ILE A 101
 None
 0.75A 3gcsA-4nq1A:
undetectable		 3gcsA-4nq1A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 VAL B 336
LEU B 436
ILE B 395
ILE B 334
 None
 0.89A 3gcsA-4ov6B:
undetectable		 3gcsA-4ov6B:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6y AMINOPEPTIDASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		4 VAL A 179
MET A   1
ILE A 217
ILE A 176
 None
 0.92A 3gcsA-4p6yA:
undetectable		 3gcsA-4p6yA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A  71
LEU A 417
MET A 418
ILE A  56
 None
 0.80A 3gcsA-4rjkA:
undetectable		 3gcsA-4rjkA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 MET B 552
LEU B 583
ILE B 736
ILE B 559
 None
 0.90A 3gcsA-4tmaB:
undetectable		 3gcsA-4tmaB:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 MET B  78
VAL B  83
LEU B 108
ILE B 146
ILE B 166
 None
None
39G  B 401 ( 4.9A)
None
None
 0.62A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 MET B  78
VAL B  83
LEU B 108
MET B 109
ILE B 166
 None
None
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
None
 1.07A 3gcsA-4tyhB:
29.9		 3gcsA-4tyhB:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt7 ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		4 VAL A 133
LEU A 305
ILE A 119
ILE A 109
 None
 0.82A 3gcsA-4wt7A:
undetectable		 3gcsA-4wt7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 MET A 763
VAL A 813
ILE A 796
ILE A 814
 None
 0.78A 3gcsA-4xriA:
undetectable		 3gcsA-4xriA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 VAL A 230
LEU A 188
ILE A 294
ILE A 231
 None
 0.61A 3gcsA-4y21A:
undetectable		 3gcsA-4y21A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 625
LEU A 644
ILE A 684
ILE A 709
 NA  A1001 (-4.9A)
None
None
None
 0.61A 3gcsA-4z7gA:
17.1		 3gcsA-4z7gA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE

(Acinetobacter
baumannii) 		PF01208
(URO-D) 		4 VAL A 247
LEU A 328
MET A  26
ILE A 206
 None
 0.96A 3gcsA-4zr8A:
undetectable		 3gcsA-4zr8A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 VAL A 258
LEU A 450
ILE A 486
ILE A 437
 None
 0.93A 3gcsA-4zzhA:
undetectable		 3gcsA-4zzhA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao8 SOLUBLE LYTIC
TRANGLYCOSILASE B3

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF13406
(SLT_2) 		4 MET A 203
VAL A 157
ILE A 184
ILE A 158
 None
 0.72A 3gcsA-5ao8A:
undetectable		 3gcsA-5ao8A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 MET A  90
VAL A 135
LEU A  76
ILE A 270
 None
 0.93A 3gcsA-5bu6A:
undetectable		 3gcsA-5bu6A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		4 VAL B 303
LEU B 128
ILE B 340
ILE B 315
 None
 0.92A 3gcsA-5cvoB:
undetectable		 3gcsA-5cvoB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbq THIOREDOXIN

(Anticarsia
gemmatalis) 		PF00085
(Thioredoxin) 		4 VAL A  79
LEU A 103
ILE A  72
ILE A  25
 None
 0.83A 3gcsA-5dbqA:
undetectable		 3gcsA-5dbqA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecx DEHYDROFOLATE
REDUCTASE TYPE I

(Klebsiella
pneumoniae) 		PF00186
(DHFR_1) 		4 VAL A   6
LEU A  29
ILE A 130
ILE A   8
 NAP  A 201 ( 3.6A)
None
None
None
 0.97A 3gcsA-5ecxA:
undetectable		 3gcsA-5ecxA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		4 MET X 115
LEU X  24
ILE X 107
ILE X  58
 None
 0.93A 3gcsA-5evyX:
undetectable		 3gcsA-5evyX:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im5 DESIGNED
KETO-HYDROXYGLUTARAT
E-ALDOLASE/KETO-DEOX
Y-PHOSPHOGLUCONATE
ALDOLASE

(Vibrionales
bacterium
SWAT-3) 		no annotation 4 VAL P  87
LEU P 154
ILE P 103
ILE P  70
 None
 0.95A 3gcsA-5im5P:
undetectable		 3gcsA-5im5P:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 774
LEU A 792
MET A 793
ILE A 853
 None
6HJ  A1101 ( 4.9A)
None
None
 0.88A 3gcsA-5j9zA:
20.2		 3gcsA-5j9zA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		4 VAL A 198
LEU A 341
ILE A  94
ILE A 335
 None
 0.73A 3gcsA-5jkjA:
undetectable		 3gcsA-5jkjA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL

(Bos taurus) 		PF00329
(Complex1_30kDa)
PF00346
(Complex1_49kDa) 		4 VAL D 376
LEU C  96
ILE D  91
ILE D 391
 None
 0.96A 3gcsA-5lc5D:
undetectable		 3gcsA-5lc5D:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 4 VAL A 197
MET A  51
ILE A 186
ILE A 166
 None
 0.95A 3gcsA-5lj9A:
undetectable		 3gcsA-5lj9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		4 MET A 371
VAL A 374
LEU A  22
ILE A 354
 None
 0.95A 3gcsA-5lq3A:
undetectable		 3gcsA-5lq3A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN10

(Saccharomyces
cerevisiae) 		PF13519
(VWA_2) 		4 VAL W   7
LEU W   3
ILE W  93
ILE W 110
 None
 0.89A 3gcsA-5mpdW:
undetectable		 3gcsA-5mpdW:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 VAL A1162
LEU A1120
ILE A1226
ILE A1163
 None
 0.56A 3gcsA-5ue8A:
undetectable		 3gcsA-5ue8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		4 VAL A 123
LEU A 138
ILE A 166
ILE A 158
 None
B12  A 802 ( 4.0A)
None
None
 0.91A 3gcsA-5ul4A:
undetectable		 3gcsA-5ul4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 VAL A 336
LEU A 436
ILE A 395
ILE A 334
 None
 0.87A 3gcsA-5vlhA:
undetectable		 3gcsA-5vlhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 VAL A 248
LEU A 269
ILE A 308
ILE A 328
 None
BI9  A 501 (-4.4A)
None
None
 0.82A 3gcsA-6bqlA:
21.2		 3gcsA-6bqlA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 211
LEU A 232
ILE A 271
ILE A 291
 None
H1N  A 501 (-4.3A)
None
None
 0.57A 3gcsA-6ccfA:
21.1		 3gcsA-6ccfA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d12 LA-RELATED PROTEIN 7

(Homo sapiens) 		no annotation 4 MET A 475
VAL A 506
ILE A 459
ILE A 507
 None
 0.92A 3gcsA-6d12A:
undetectable		 3gcsA-6d12A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fm7 BETA-LACTAMASE

(Aeromonas
enteropelogenes) 		no annotation 4 VAL A  30
MET A 237
ILE A   9
ILE A 333
 None
 0.76A 3gcsA-6fm7A:
undetectable		 3gcsA-6fm7A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 4 MET A 142
VAL A 316
ILE A 124
ILE A 312
 None
 0.90A 3gcsA-6ftlA:
undetectable		 3gcsA-6ftlA:
13.20