SIMILAR PATTERNS OF AMINO ACIDS FOR 3GAN_A_SVRA158_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bft NUCLEAR FACTOR
NF-KAPPA-B P65

(Mus musculus) 		PF16179
(RHD_dimer) 		5 ARG A 198
GLN A 287
VAL A 268
ILE A 196
ILE A 212
 None
 1.40A 3ganA-1bftA:
undetectable		 3ganA-1bftA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii) 		PF00995
(Sec1) 		5 ARG A 586
GLN A 442
VAL A 446
PRO A 236
TYR A 400
 None
 1.43A 3ganA-1fvfA:
0.0		 3ganA-1fvfA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvi CHLORELLA VIRUS DNA
LIGASE-ADENYLATE

(Chlorella virus) 		PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2) 		5 TYR A 109
VAL A 113
PRO A 139
ILE A 165
PRO A  26
 None
None
None
None
AMP  A 501 (-4.8A)
 1.41A 3ganA-1fviA:
undetectable		 3ganA-1fviA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		5 VAL A 162
PRO A 127
PRO A 145
ILE A 185
ILE A 153
 None
 1.42A 3ganA-1hg3A:
undetectable		 3ganA-1hg3A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i31 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		6 ARG A 323
GLN A 318
VAL A 392
PRO A 393
PRO A 286
ILE A 307
 None
 1.31A 3ganA-1i31A:
undetectable		 3ganA-1i31A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		5 GLN A 286
PRO A  97
TRP A 263
ILE A 207
ILE A 183
 None
 1.26A 3ganA-1ms8A:
undetectable		 3ganA-1ms8A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pek PROTEINASE K

(Parengyodontium
album) 		PF00082
(Peptidase_S8) 		5 GLN E 149
VAL E 177
PRO E 171
ILE E 108
ILE E  38
 None
 1.19A 3ganA-1pekE:
undetectable		 3ganA-1pekE:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 GLN X 200
VAL X 201
PRO X 210
ILE X 245
ILE X 223
 None
 1.21A 3ganA-1r6bX:
0.0		 3ganA-1r6bX:
11.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vk5 EXPRESSED PROTEIN

(Arabidopsis
thaliana) 		PF09187
(RdDM_RDM1) 		8 ARG A  41
TYR A  48
GLN A  51
VAL A  52
PRO A  53
PRO A  81
TRP A 140
ILE A 150
 CPS  A 200 ( 4.6A)
CPS  A 200 (-4.2A)
None
None
None
EDO  A 401 (-4.1A)
None
CPS  A 200 (-4.2A)
 0.95A 3ganA-1vk5A:
20.4		 3ganA-1vk5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vk5 EXPRESSED PROTEIN

(Arabidopsis
thaliana) 		PF09187
(RdDM_RDM1) 		6 GLN A  51
PRO A  81
TRP A 140
TYR A 146
ILE A 150
ILE A 153
 None
EDO  A 401 (-4.1A)
None
None
CPS  A 200 (-4.2A)
EDO  A 401 (-4.4A)
 0.94A 3ganA-1vk5A:
20.4		 3ganA-1vk5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vk5 EXPRESSED PROTEIN

(Arabidopsis
thaliana) 		PF09187
(RdDM_RDM1) 		8 TYR A  48
GLN A  51
VAL A  52
PRO A  53
PRO A  81
TRP A 140
TYR A 146
ILE A 150
 CPS  A 200 (-4.2A)
None
None
None
EDO  A 401 (-4.1A)
None
None
CPS  A 200 (-4.2A)
 0.67A 3ganA-1vk5A:
20.4		 3ganA-1vk5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 PRO A 143
TYR A 242
ILE A 241
ILE A 288
PRO A 156
 None
 1.46A 3ganA-1vknA:
0.0		 3ganA-1vknA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1n 4-ALPHA-GLUCANOTRANS
FERASE

(Solanum
tuberosum) 		PF02446
(Glyco_hydro_77) 		5 PRO A 114
TYR A 124
ILE A 127
ILE A 135
PRO A 133
 None
 1.41A 3ganA-1x1nA:
0.0		 3ganA-1x1nA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT

(Streptomyces
coelicolor) 		PF01039
(Carboxyl_trans) 		5 VAL A 288
PRO A 289
ILE A 497
ILE A 412
PRO A 484
 None
 1.02A 3ganA-1xnyA:
0.0		 3ganA-1xnyA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		5 GLN A 108
VAL A 110
PRO A 111
TYR A  50
PRO A  84
 None
 1.14A 3ganA-1yewA:
undetectable		 3ganA-1yewA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		5 ARG A  24
GLN A 223
VAL A 229
ILE A  18
PRO A 188
 None
None
None
None
NAP  A 800 (-3.7A)
 1.50A 3ganA-2bd0A:
undetectable		 3ganA-2bd0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ARG M 323
GLN M 318
PRO M 393
PRO M 286
ILE M 307
 None
 1.46A 3ganA-2bp5M:
undetectable		 3ganA-2bp5M:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp5 CLATHRIN COAT
ASSEMBLY PROTEIN
AP50

(Rattus
norvegicus) 		PF00928
(Adap_comp_sub) 		5 ARG M 323
VAL M 392
PRO M 393
PRO M 286
ILE M 307
 None
 1.23A 3ganA-2bp5M:
undetectable		 3ganA-2bp5M:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwq REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2

(Rattus
norvegicus) 		PF00168
(C2) 		5 GLN A 743
VAL A 803
PRO A 802
ILE A 836
ILE A 769
 None
 1.47A 3ganA-2bwqA:
undetectable		 3ganA-2bwqA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0b NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 ARG A 377
GLN A 302
PRO A 300
ILE A 344
PRO A 433
 None
 1.31A 3ganA-2h0bA:
undetectable		 3ganA-2h0bA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		5 TYR A 206
GLN A 207
TYR A 159
ILE A 173
ILE A 178
 None
 1.32A 3ganA-2i3fA:
undetectable		 3ganA-2i3fA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfn FIBRONECTIN

(Mus musculus) 		PF00041
(fn3) 		5 GLN A 136
VAL A 135
PRO A 134
ILE A 180
PRO A 177
 None
 1.48A 3ganA-2mfnA:
undetectable		 3ganA-2mfnA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 ARG A 150
VAL A 164
PRO A 165
ILE A 160
ILE A 188
 None
 1.45A 3ganA-2ocaA:
0.0		 3ganA-2ocaA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of7 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		5 ARG A  54
TYR A  43
VAL A 128
PRO A 129
ILE A  72
 None
 1.47A 3ganA-2of7A:
0.0		 3ganA-2of7A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 GLN A 190
PRO A 430
ILE A 158
ILE A 179
PRO A 356
 None
None
None
None
ATP  A 506 ( 4.2A)
 1.47A 3ganA-2r9vA:
undetectable		 3ganA-2r9vA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 PRO A 158
TYR A  96
ILE A  93
ILE A  39
PRO A  41
 None
 1.48A 3ganA-2vo1A:
undetectable		 3ganA-2vo1A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 VAL A 301
PRO A 300
ILE A 290
ILE A 249
PRO A 248
 None
 1.17A 3ganA-2x7jA:
undetectable		 3ganA-2x7jA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		5 ARG A  62
TYR A  95
VAL A   6
PRO A 130
ILE A 170
 None
 1.32A 3ganA-3a3hA:
undetectable		 3ganA-3a3hA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 GLN A 176
VAL A 188
TYR A 105
ILE A 166
ILE A 135
 None
 1.41A 3ganA-3a9lA:
undetectable		 3ganA-3a9lA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf2 PUTATIVE LIPOPROTEIN

(Neisseria
meningitidis) 		PF04390
(LptE) 		5 ARG A  69
GLN A  75
PRO A  46
ILE A  37
ILE A 149
 None
 1.25A 3ganA-3bf2A:
undetectable		 3ganA-3bf2A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 VAL A 421
PRO A 422
ILE A 441
ILE A 457
PRO A 456
 None
 1.46A 3ganA-3csgA:
undetectable		 3ganA-3csgA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmt ADENYLATE KINASE

(Burkholderia
pseudomallei) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 TYR A 171
GLN A 174
PRO A 177
ILE A 116
ILE A 109
 None
 1.41A 3ganA-3gmtA:
undetectable		 3ganA-3gmtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2m MONOBODY HA4

(Homo sapiens) 		PF00041
(fn3) 		5 GLN C  51
VAL C  50
PRO C  49
ILE C  96
PRO C  93
 None
 1.16A 3ganA-3k2mC:
undetectable		 3ganA-3k2mC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4i UNCHARACTERIZED
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF03737
(RraA-like) 		5 TYR A  77
GLN A  80
VAL A  81
PRO A  82
ILE A 103
 None
None
None
None
CL  A 502 (-4.1A)
 1.32A 3ganA-3k4iA:
undetectable		 3ganA-3k4iA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfn NAD KINASE

(Homo sapiens) 		PF01513
(NAD_kinase) 		5 VAL A 360
PRO A 361
TYR A 327
ILE A 317
ILE A 368
 None
None
None
UNX  A   8 ( 4.3A)
None
 1.47A 3ganA-3pfnA:
undetectable		 3ganA-3pfnA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8y NUCLEOSIDE
DIPHOSPHATE KINASE

(Staphylococcus
aureus) 		PF00334
(NDK) 		5 ARG A  15
GLN A  39
VAL A  40
PRO A  41
ILE A   8
 None
 1.39A 3ganA-3q8yA:
undetectable		 3ganA-3q8yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 PRO A 173
PRO A 356
TRP A 347
ILE A 350
ILE A 214
 None
 1.26A 3ganA-3qfvA:
undetectable		 3ganA-3qfvA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN

(Yersinia pestis) 		PF01557
(FAA_hydrolase) 		5 ARG A 105
VAL A  58
PRO A  57
PRO A 129
ILE A  71
 None
 1.35A 3ganA-3s52A:
undetectable		 3ganA-3s52A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT

(uncultured
archaeon) 		PF02240
(MCR_gamma) 		5 ARG C 147
TYR C  87
GLN C  86
VAL C  85
ILE C  96
 None
 1.29A 3ganA-3sqgC:
undetectable		 3ganA-3sqgC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 ARG A  22
GLN A 220
VAL A 221
ILE A   9
ILE A  16
 None
HEZ  A 265 ( 3.8A)
HEZ  A 265 ( 4.9A)
None
None
 1.05A 3ganA-3tfoA:
undetectable		 3ganA-3tfoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tze TRYPTOPHANYL-TRNA
SYNTHETASE

(Encephalitozoon
cuniculi) 		PF00579
(tRNA-synt_1b) 		5 TYR A 321
VAL A 317
PRO A 260
ILE A 100
ILE A  96
 None
 1.40A 3ganA-3tzeA:
undetectable		 3ganA-3tzeA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN H  39
PRO H  41
TYR H  59
ILE H  67
ILE H  20
 None
 1.32A 3ganA-3ujiH:
undetectable		 3ganA-3ujiH:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 ARG A 563
GLN A 589
VAL A 590
ILE A 561
ILE A 605
 None
 1.36A 3ganA-3v9fA:
undetectable		 3ganA-3v9fA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg UNCHARACTERIZED
PROTEIN
URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG)
PF06106
(SAUGI) 		5 TYR A  61
VAL A  74
PRO A 102
ILE B  28
PRO A 181
 None
 1.50A 3ganA-3wdgA:
undetectable		 3ganA-3wdgA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zv8 3C PROTEASE

(Enterovirus D) 		PF00548
(Peptidase_C3) 		5 ARG A 134
VAL A 116
PRO A 115
ILE A 135
ILE A 160
 None
 1.49A 3ganA-3zv8A:
undetectable		 3ganA-3zv8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8v EXTRACELLULAR
PROTEIN 6

(Passalora fulva) 		PF01476
(LysM) 		5 VAL A 131
PRO A 132
PRO A  85
ILE A 167
PRO A 188
 None
 1.14A 3ganA-4b8vA:
undetectable		 3ganA-4b8vA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 PRO A 343
PRO A 498
TYR A 454
ILE A 485
ILE A 490
 None
 1.36A 3ganA-4be9A:
undetectable		 3ganA-4be9A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		5 ARG B  80
PRO B 240
ILE B 271
ILE B 259
PRO B 257
 None
 1.44A 3ganA-4dhiB:
undetectable		 3ganA-4dhiB:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 ARG A 247
TYR A 243
VAL A 228
PRO A 229
PRO A 105
 None
 1.30A 3ganA-4g2cA:
undetectable		 3ganA-4g2cA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		5 ARG A 161
VAL A  40
ILE A 152
ILE A  44
PRO A  21
 None
 1.32A 3ganA-4ihqA:
undetectable		 3ganA-4ihqA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLN A 122
VAL A 121
TYR A 189
ILE A 307
PRO A 333
 None
 1.29A 3ganA-4l9rA:
undetectable		 3ganA-4l9rA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb6 VP1

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 VAL A 264
PRO A 263
TYR A 251
ILE A 234
ILE A 268
 None
 1.45A 3ganA-4pb6A:
undetectable		 3ganA-4pb6A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran)
PF13793
(Pribosyltran_N) 		5 ARG A  40
VAL A 116
TYR A  38
ILE A  39
ILE A   4
 None
 1.35A 3ganA-4twbA:
undetectable		 3ganA-4twbA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02686
(Glu-tRNAGln) 		5 ARG A 381
GLN C  42
PRO A 305
ILE A 383
ILE A 310
 None
 1.24A 3ganA-4wj3A:
undetectable		 3ganA-4wj3A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye5 PEPTIDOGLYCAN
SYNTHETASE
PENICILLIN-BINDING
PROTEIN 3

(Bifidobacterium
adolescentis) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ARG A 429
TYR A 438
VAL A 440
PRO A 319
TYR A 356
 None
 1.42A 3ganA-4ye5A:
undetectable		 3ganA-4ye5A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		5 ARG A 232
VAL A 207
PRO A 208
PRO A 202
ILE A 471
 None
 1.50A 3ganA-4yjiA:
undetectable		 3ganA-4yjiA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ARG A 601
VAL A 703
PRO A 704
TYR A 614
ILE A 734
 None
 1.41A 3ganA-4zg7A:
undetectable		 3ganA-4zg7A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zw2 VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1,VOLTAGE-DEPEN
DENT L-TYPE CALCIUM
CHANNEL SUBUNIT
BETA-1

(Mus musculus) 		PF00625
(Guanylate_kin)
PF12052
(VGCC_beta4Aa_N) 		5 GLN A 247
PRO A 255
ILE A 148
ILE A 225
PRO A 143
 None
 1.47A 3ganA-4zw2A:
undetectable		 3ganA-4zw2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		5 TYR C 532
GLN C 529
TYR C 995
ILE C1013
PRO C 503
 None
 1.47A 3ganA-5a6fC:
undetectable		 3ganA-5a6fC:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d95 AMINOTRANSFERASE
CLASS-III

(Sphaerobacter
thermophilus) 		PF00202
(Aminotran_3) 		5 PRO A 171
PRO A 198
TYR A 248
ILE A 209
ILE A 202
 None
 1.39A 3ganA-5d95A:
undetectable		 3ganA-5d95A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqr 7-HYDROXYMETHYL
CHLOROPHYLL A
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 VAL A 319
PRO A 320
PRO A 331
ILE A 135
ILE A 354
 None
None
None
FAD  A 503 (-4.4A)
None
 1.33A 3ganA-5dqrA:
undetectable		 3ganA-5dqrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLN A 320
VAL A 317
TYR A 305
ILE A 309
ILE A 246
 None
 1.29A 3ganA-5eytA:
undetectable		 3ganA-5eytA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 PRO A 135
PRO A 151
TYR A 238
ILE A 250
ILE A 141
 None
 1.37A 3ganA-5f7sA:
undetectable		 3ganA-5f7sA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ARG A 295
VAL A 331
PRO A 394
ILE A 376
PRO A 381
 None
 1.50A 3ganA-5fkuA:
undetectable		 3ganA-5fkuA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		5 TYR A 332
VAL A 336
TYR A 365
ILE A 376
ILE A 346
 None
 1.48A 3ganA-5gsmA:
undetectable		 3ganA-5gsmA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2u CELLULASE

(soil metagenome) 		PF00150
(Cellulase) 		5 ARG A  69
TYR A 104
VAL A  13
PRO A 134
ILE A 171
 None
 1.35A 3ganA-5i2uA:
undetectable		 3ganA-5i2uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipw OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 GLN A 326
PRO A 652
TYR A 210
ILE A 106
PRO A 267
 None
 1.17A 3ganA-5ipwA:
undetectable		 3ganA-5ipwA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		5 TYR A 104
PRO A 123
TYR A  86
ILE A 126
PRO A  94
 None
 1.14A 3ganA-5j9rA:
undetectable		 3ganA-5j9rA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		5 VAL A 118
PRO A 123
TYR A  86
ILE A 126
PRO A  94
 None
 1.21A 3ganA-5j9rA:
undetectable		 3ganA-5j9rA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN

(Homo sapiens) 		no annotation 5 GLN L  39
VAL L  40
PRO L  41
ILE L  59
ILE L  76
 None
 1.48A 3ganA-5ocyL:
undetectable		 3ganA-5ocyL:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 TYR A 422
VAL A 389
PRO A 390
ILE A 565
ILE A 484
 None
None
None
TRS  A 703 (-4.9A)
None
 1.50A 3ganA-5opqA:
undetectable		 3ganA-5opqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 TYR A 607
VAL A 623
PRO A 624
ILE A 662
ILE A 657
 None
None
None
None
MJ8  A1601 (-4.7A)
 1.49A 3ganA-5u89A:
undetectable		 3ganA-5u89A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd6 SHORT PALATE, LUNG
AND NASAL EPITHELIUM
CARCINOMA-ASSOCIATED
PROTEIN 2B

(Bos taurus) 		no annotation 5 GLN A 109
VAL A 110
PRO A 111
ILE A  60
ILE A  93
 None
 1.36A 3ganA-5wd6A:
undetectable		 3ganA-5wd6A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpk 3-HYDROXY-3-METHYLGL
UTARYL COENZYME A
REDUCTASE

(Streptococcus
pneumoniae) 		no annotation 5 TYR A  77
VAL A  63
PRO A  64
ILE A 274
ILE A 269
 None
 1.45A 3ganA-5wpkA:
undetectable		 3ganA-5wpkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrk AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 5 ARG A 323
VAL A 392
PRO A 393
PRO A 286
ILE A 307
 None
 1.30A 3ganA-5wrkA:
undetectable		 3ganA-5wrkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrl AP-2 COMPLEX SUBUNIT
MU

(Rattus
norvegicus) 		no annotation 6 ARG A 323
GLN A 318
VAL A 392
PRO A 393
PRO A 286
ILE A 307
 None
 1.40A 3ganA-5wrlA:
undetectable		 3ganA-5wrlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrt SOLUBLE INORGANIC
PYROPHOSPHATASE

(Toxoplasma
gondii) 		no annotation 5 VAL A 210
PRO A 211
TYR A 158
ILE A 126
ILE A 145
 None
 1.43A 3ganA-5wrtA:
undetectable		 3ganA-5wrtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 5 GLN A 484
VAL A 483
PRO A 482
PRO A 176
ILE A 397
 None
 1.27A 3ganA-5ww1A:
undetectable		 3ganA-5ww1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN

(Rhinocladiella
mackenziei) 		no annotation 5 ARG A  81
GLN A  76
PRO A  62
TYR A 118
PRO A  33
 None
 1.46A 3ganA-5z97A:
undetectable		 3ganA-5z97A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MONOBODY YSX1

(synthetic
construct) 		no annotation 5 GLN B  46
VAL B  45
PRO B  44
ILE B  88
PRO B  85
 None
 1.12A 3ganA-6apxB:
undetectable		 3ganA-6apxB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 5 ARG A 157
TYR A 151
VAL A 147
PRO A 144
PRO A 187
 None
 1.47A 3ganA-6bk1A:
undetectable		 3ganA-6bk1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0e ISOCITRATE
DEHYDROGENASE

(Legionella
pneumophila) 		no annotation 5 VAL A 143
PRO A 144
ILE A 383
ILE A 363
PRO A 330
 None
 1.36A 3ganA-6c0eA:
undetectable		 3ganA-6c0eA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE

(Klebsiella
pneumoniae) 		no annotation 5 VAL A 362
PRO A 367
ILE A 165
ILE A 340
PRO A 342
 None
 1.45A 3ganA-6duxA:
undetectable		 3ganA-6duxA:
19.61