SIMILAR PATTERNS OF AMINO ACIDS FOR 3G9E_A_RO7A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2i PROTEIN (RESTRICTION
ENDONUCLEASE BGLII)

(Bacillus
subtilis) 		PF09195
(Endonuc-BglII) 		5 HIS A  33
LEU A 170
VAL A 168
ILE A 128
LYS A   1
 None
 1.06A 3g9eA-1d2iA:
undetectable		 3g9eA-1d2iA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		5 GLY A 100
LEU A 128
VAL A 162
ILE A 158
LEU A  89
 None
 1.22A 3g9eA-1di6A:
0.0		 3g9eA-1di6A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE

(Homo sapiens) 		PF00494
(SQS_PSY) 		5 LEU A 186
VAL A 142
ILE A 146
LEU A  47
TYR A  44
 None
 1.28A 3g9eA-1ezfA:
1.6		 3g9eA-1ezfA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 GLY A 126
CYH A  79
LEU A 294
LEU A 370
TYR A 371
 None
 1.27A 3g9eA-1h79A:
0.0		 3g9eA-1h79A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 GLY A 158
LEU A  36
VAL A  34
ILE A 103
LEU A  55
 None
 1.14A 3g9eA-1i2dA:
0.0		 3g9eA-1i2dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jiu DNA
BETA-GLUCOSYLTRANSFE
RASE

(Escherichia
virus T4) 		PF09198
(T4-Gluco-transf) 		5 GLY A   9
SER A  82
TYR A 121
LEU A 126
LEU A  42
 None
 1.25A 3g9eA-1jiuA:
0.0		 3g9eA-1jiuA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		5 GLY 2  77
HIS 2 130
LEU 2 222
VAL 2 110
ILE 2 242
 None
 1.11A 3g9eA-1r1a2:
0.0		 3g9eA-1r1a2:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 GLY A 223
HIS A 121
TYR A 338
LEU A 351
LEU A 158
 None
 1.28A 3g9eA-1rt8A:
0.0		 3g9eA-1rt8A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdo BSTYI

(Geobacillus
stearothermophilus) 		PF09195
(Endonuc-BglII) 		5 GLY A 157
TYR A 177
LEU A 161
VAL A 137
LEU A  13
 None
 1.24A 3g9eA-1sdoA:
0.0		 3g9eA-1sdoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4b ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Escherichia
coli) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 GLY A   5
LEU A 366
ILE A  30
LEU A  85
TYR A  82
 None
 1.29A 3g9eA-1t4bA:
undetectable		 3g9eA-1t4bA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzm 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Pseudomonas sp.
ACP) 		PF00291
(PALP) 		5 GLY A 161
CYH A 162
TYR A 156
LEU A  70
VAL A  87
 C2N  A 501 (-3.4A)
None
None
None
None
 1.27A 3g9eA-1tzmA:
undetectable		 3g9eA-1tzmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we0 ALKYL HYDROPEROXIDE
REDUCTASE C

(Amphibacillus
xylanus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		5 LEU A  29
VAL A   7
ILE A 131
LEU A  61
TYR A  58
 None
 1.14A 3g9eA-1we0A:
undetectable		 3g9eA-1we0A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yud HYPOTHETICAL PROTEIN
SO0799

(Shewanella
oneidensis) 		PF06172
(Cupin_5) 		5 GLY A 120
CYH A 121
LEU A  57
VAL A 101
HIS A  16
 None
 1.21A 3g9eA-1yudA:
undetectable		 3g9eA-1yudA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		5 SER A 200
LEU A 230
VAL A 153
ILE A 155
HIS A 225
 None
 1.22A 3g9eA-1zyoA:
undetectable		 3g9eA-1zyoA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		5 GLY A  71
TYR A 135
LEU A  79
VAL A 237
ILE A 168
 None
 1.28A 3g9eA-2btwA:
undetectable		 3g9eA-2btwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		5 GLY A 381
TYR A 194
LEU A 196
VAL A 226
LEU A 181
 3PG  A 503 (-3.5A)
None
None
None
None
 1.24A 3g9eA-2cunA:
undetectable		 3g9eA-2cunA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7t ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, HEAVY
CHAIN
ANTI
POLYHYDROXYBUTYRATE
ANTIBODY FV, LIGHT
CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 GLY H  49
VAL H  79
ILE H  51
LEU L  89
TYR L  36
 None
 1.22A 3g9eA-2d7tH:
undetectable		 3g9eA-2d7tH:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  43
CYH A  42
SER A  40
VAL A 119
ILE A  48
 NAD  A1401 ( 4.7A)
NAD  A1401 (-3.3A)
None
None
None
 1.29A 3g9eA-2dfvA:
undetectable		 3g9eA-2dfvA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 LEU A  82
VAL A 341
ILE A   5
LEU A  65
TYR A  46
 None
 1.14A 3g9eA-2ep5A:
undetectable		 3g9eA-2ep5A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 SER A 155
VAL A   5
ILE A  39
LEU A 238
TYR A 239
 None
 1.26A 3g9eA-2fpqA:
undetectable		 3g9eA-2fpqA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 GLY A  81
SER A  83
LEU A  97
VAL A  59
ILE A  79
 None
 1.18A 3g9eA-2gupA:
undetectable		 3g9eA-2gupA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		5 CYH A  30
LEU A  71
VAL A  73
ILE A  49
LEU A  10
 None
 1.29A 3g9eA-2h1rA:
undetectable		 3g9eA-2h1rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1r DIMETHYLADENOSINE
TRANSFERASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00398
(RrnaAD) 		5 GLY A  29
CYH A  30
LEU A  71
VAL A  73
ILE A  49
 None
 1.19A 3g9eA-2h1rA:
undetectable		 3g9eA-2h1rA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2he3 GLUTATHIONE
PEROXIDASE 2

(Homo sapiens) 		PF00255
(GSHPx) 		5 LEU A  64
VAL A  21
ILE A  14
LEU A  86
TYR A  95
 None
 1.13A 3g9eA-2he3A:
undetectable		 3g9eA-2he3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 112
TYR A 121
LEU A  80
VAL A  86
ILE A  88
 None
 1.18A 3g9eA-2hjrA:
undetectable		 3g9eA-2hjrA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE

(Streptomyces
exfoliatus) 		PF13561
(adh_short_C2) 		5 GLY A  19
LEU A 225
VAL A 135
ILE A 137
LEU A  50
 NAD  A 256 (-4.5A)
None
None
NAD  A 256 (-4.6A)
None
 1.22A 3g9eA-2hsdA:
undetectable		 3g9eA-2hsdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jcs DEOXYNUCLEOSIDE
KINASE

(Drosophila
melanogaster) 		PF01712
(dNK) 		5 SER A  31
LEU A 180
VAL A 175
HIS A 187
TYR A 152
 TTP  A1210 (-3.3A)
None
None
None
None
 1.29A 3g9eA-2jcsA:
undetectable		 3g9eA-2jcsA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 276
LEU A 321
ILE A 339
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.39A 3g9eA-2p54A:
37.6		 3g9eA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
SER A 280
LYS A 358
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
None
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.86A 3g9eA-2p54A:
37.6		 3g9eA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qi2 CELL DIVISION
PROTEIN PELOTA
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		5 SER A  31
HIS A 117
LEU A  26
VAL A 101
ILE A  99
 None
 1.20A 3g9eA-2qi2A:
undetectable		 3g9eA-2qi2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rs5 HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus B) 		PF00073
(Rhv) 		5 GLY 2  77
HIS 2 130
LEU 2 220
VAL 2 110
ILE 2 240
 None
 0.97A 3g9eA-2rs52:
undetectable		 3g9eA-2rs52:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		5 TYR A 130
LEU A 133
VAL A 115
ILE A  94
LEU A 164
 None
 1.19A 3g9eA-2v1uA:
undetectable		 3g9eA-2v1uA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 HIS A 401
LEU A 168
VAL A 231
ILE A 342
TYR A 277
 None
 1.28A 3g9eA-2vz9A:
undetectable		 3g9eA-2vz9A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 GLY A  50
SER A 293
HIS A 268
TYR A 270
ILE A 370
 None
None
GOL  A1449 ( 4.8A)
None
None
 1.17A 3g9eA-2wnwA:
undetectable		 3g9eA-2wnwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.92A 3g9eA-3aqcB:
undetectable		 3g9eA-3aqcB:
23.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 GLY A 284
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
VAL A 339
ILE A 341
LYS A 367
HIS A 449
LEU A 469
TYR A 473
 MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
None
MC5  A   1 (-3.9A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.54A 3g9eA-3b0qA:
40.3		 3g9eA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		5 SER A 207
LEU A 120
VAL A 122
ILE A 150
LEU A 185
 None
 1.22A 3g9eA-3bacA:
undetectable		 3g9eA-3bacA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		5 GLY A  50
CYH A  49
HIS A 132
VAL A 247
LEU A 174
 None
 1.18A 3g9eA-3bn1A:
undetectable		 3g9eA-3bn1A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		5 GLY A 585
HIS A 120
ILE A 593
LYS A 637
HIS A 250
 None
None
None
WCC  A 811 ( 3.6A)
FE  A 808 ( 3.2A)
 0.98A 3g9eA-3cf4A:
undetectable		 3g9eA-3cf4A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvo METHYLTRANSFERASE-LI
KE PROTEIN OF
UNKNOWN FUNCTION

(Ruegeria
pomeroyi) 		no annotation 5 GLY A 134
CYH A 135
LEU A  34
VAL A  56
LEU A 167
 None
None
EDO  A 205 ( 4.3A)
None
None
 1.20A 3g9eA-3cvoA:
undetectable		 3g9eA-3cvoA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 GLY A  40
CYH A  41
LEU A  48
VAL A  80
LYS A  72
 None
 1.25A 3g9eA-3d2lA:
undetectable		 3g9eA-3d2lA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		5 GLY A  48
LEU A 158
VAL A 213
ILE A  19
LEU A  68
 None
 1.26A 3g9eA-3d34A:
undetectable		 3g9eA-3d34A:
24.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 285
HIS A 323
LEU A 330
LYS A 367
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.65A 3g9eA-3d5fA:
37.0		 3g9eA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 HIS A 323
LEU A 330
VAL A 334
LYS A 367
HIS A 449
TYR A 473
 L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
None
None
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 1.39A 3g9eA-3d5fA:
37.0		 3g9eA-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dpr PROTEIN VP2

(Rhinovirus A) 		PF00073
(Rhv) 		5 GLY B  77
HIS B 130
LEU B 223
VAL B 110
ILE B 242
 None
 1.08A 3g9eA-3dprB:
undetectable		 3g9eA-3dprB:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A 139
LEU A 355
VAL A 358
HIS A 132
LEU A 105
 None
 1.23A 3g9eA-3dtyA:
undetectable		 3g9eA-3dtyA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
VAL D 339
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
None
None
 0.91A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
LEU D 330
VAL D 339
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
None
None
 0.93A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 GLY D 284
LEU D 330
VAL D 339
ILE D 341
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
None
None
None
 0.68A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 GLY D 284
SER D 289
ILE D 341
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 (-3.3A)
PLB  D 701 ( 3.9A)
PLB  D 701 (-3.6A)
None
None
None
 0.91A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 HIS D 323
TYR D 327
HIS D 449
LEU D 469
TYR D 473
 None
 1.19A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
TYR D 327
ILE D 341
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 (-3.6A)
None
None
None
 1.00A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
VAL D 339
ILE D 341
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
None
None
None
 0.80A 3g9eA-3dzuD:
37.2		 3g9eA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		5 SER A  68
HIS A 490
VAL A  92
ILE A  85
HIS A 489
 None
 1.16A 3g9eA-3e2dA:
undetectable		 3g9eA-3e2dA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg2 PUTATIVE RUBREDOXIN
REDUCTASE

(Rhodopseudomonas
palustris) 		PF07992
(Pyr_redox_2)
PF14759
(Reductase_C) 		5 GLY P   8
LEU P  20
VAL P 303
ILE P 273
LEU P  74
 FAD  P 449 (-3.3A)
None
None
None
None
 1.18A 3g9eA-3fg2P:
undetectable		 3g9eA-3fg2P:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		5 GLY A  46
CYH A  45
HIS A 180
VAL A 155
ILE A  84
 None
None
FE2  A 534 (-3.4A)
None
None
 1.25A 3g9eA-3fsnA:
undetectable		 3g9eA-3fsnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g77 CYTOSINE DEAMINASE

(Escherichia
coli) 		PF07969
(Amidohydro_3) 		5 GLY A 401
SER A 373
VAL A  53
ILE A   8
HIS A 118
 None
 1.12A 3g9eA-3g77A:
undetectable		 3g9eA-3g77A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqc DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF00817
(IMS)
PF11799
(IMS_C) 		5 GLY A 797
LEU A 743
VAL A 821
ILE A 819
LYS A 749
 None
 1.21A 3g9eA-3gqcA:
undetectable		 3g9eA-3gqcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0a TOLL-LIKE RECEPTOR 5

(Homo sapiens) 		PF01582
(TIR)
PF13855
(LRR_8) 		5 GLY A 270
LEU A 303
VAL A 300
ILE A 264
LYS A 326
 None
 1.27A 3g9eA-3j0aA:
undetectable		 3g9eA-3j0aA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw2 PROBABLE R-RNA
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		PF04452
(Methyltrans_RNA) 		5 GLY A 196
LEU A 192
VAL A 151
ILE A 148
LEU A 219
 ADN  A 300 (-3.2A)
None
None
None
ADN  A 300 (-4.1A)
 1.11A 3g9eA-3kw2A:
undetectable		 3g9eA-3kw2A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		5 SER A 391
LEU A 341
VAL A 270
ILE A 261
LYS A 339
 None
 1.18A 3g9eA-3om5A:
undetectable		 3g9eA-3om5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfw DIHYDROPYRIMIDINASE

(Brevibacillus
agri) 		PF01979
(Amidohydro_1) 		5 GLY A 307
SER A 302
LEU A 268
VAL A 312
ILE A 367
 None
 1.14A 3g9eA-3sfwA:
undetectable		 3g9eA-3sfwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		5 GLY A 386
SER A 381
LEU A 401
ILE A 419
LEU A 344
 None
 1.20A 3g9eA-3swgA:
undetectable		 3g9eA-3swgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		5 SER A 149
LEU A 167
VAL A 256
LEU A 103
TYR A 101
 None
 1.07A 3g9eA-3w04A:
undetectable		 3g9eA-3w04A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 5 GLY A 393
VAL A 340
ILE A 395
HIS A 155
LEU A  57
 None
 1.29A 3g9eA-4a7kA:
undetectable		 3g9eA-4a7kA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 GLY A  84
TYR A 107
LEU A 108
VAL A  99
LEU A  52
 None
 1.29A 3g9eA-4b8sA:
undetectable		 3g9eA-4b8sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckk DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF00521
(DNA_topoisoIV) 		5 CYH A 194
HIS A 185
LEU A 187
VAL A 509
LEU A 347
 None
 1.29A 3g9eA-4ckkA:
undetectable		 3g9eA-4ckkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		5 SER A 823
HIS A 829
LEU A 833
ILE A 918
LEU A 827
 None
None
ADP  A1201 (-3.9A)
None
None
 1.26A 3g9eA-4d86A:
undetectable		 3g9eA-4d86A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1326
SER A1206
LEU A1257
VAL A1229
ILE A1322
 None
 1.21A 3g9eA-4fodA:
undetectable		 3g9eA-4fodA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		5 GLY A 510
SER A 330
LEU A 340
ILE A 326
LEU A 360
 FAD  A 601 (-3.0A)
None
None
None
None
 1.29A 3g9eA-4iv9A:
undetectable		 3g9eA-4iv9A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		5 GLY A 307
SER A 302
LEU A 268
VAL A 312
ILE A 367
 GLY  A 307 ( 0.0A)
SER  A 302 ( 0.0A)
LEU  A 268 ( 0.6A)
VAL  A 312 ( 0.6A)
ILE  A 367 ( 0.4A)
 1.28A 3g9eA-4kqnA:
undetectable		 3g9eA-4kqnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 GLY A  84
LEU A  49
VAL A  62
ILE A  26
LEU A 165
 None
 1.27A 3g9eA-4lomA:
undetectable		 3g9eA-4lomA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 GLY A 225
LEU A  17
VAL A  50
ILE A  38
LEU A 242
 DCS  A 401 (-3.3A)
None
None
None
None
 1.29A 3g9eA-4lutA:
undetectable		 3g9eA-4lutA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 GLY A 598
SER A 672
LEU A 629
VAL A 605
HIS A 254
 None
 1.24A 3g9eA-4o9xA:
undetectable		 3g9eA-4o9xA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris) 		PF12697
(Abhydrolase_6) 		5 SER A  55
HIS A 114
LEU A  45
VAL A  69
LEU A 272
 None
 1.21A 3g9eA-4psuA:
undetectable		 3g9eA-4psuA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		5 GLY A 147
LEU A 189
VAL A 222
ILE A 294
LEU A 140
 None
 1.28A 3g9eA-4w8xA:
undetectable		 3g9eA-4w8xA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 GLY A  21
LEU A  87
VAL A 140
ILE A 237
LEU A  50
 None
 1.29A 3g9eA-4y9dA:
undetectable		 3g9eA-4y9dA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 GLY A  97
SER A  93
LEU A  39
VAL A  78
ILE A 102
 None
 1.19A 3g9eA-4z64A:
undetectable		 3g9eA-4z64A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		5 GLY A 144
SER A  98
HIS A  95
LEU A  93
VAL A  62
 None
 1.13A 3g9eA-5aeoA:
undetectable		 3g9eA-5aeoA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 GLY B  77
HIS B 130
LEU B 209
VAL B 110
ILE B 228
 None
 0.99A 3g9eA-5bnnB:
undetectable		 3g9eA-5bnnB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 SER A 155
VAL A   5
ILE A  39
LEU A 238
TYR A 239
 None
 1.23A 3g9eA-5bqnA:
undetectable		 3g9eA-5bqnA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		5 GLY A 163
CYH A 165
LEU A 103
VAL A 101
ILE A  97
 None
 1.09A 3g9eA-5ddbA:
undetectable		 3g9eA-5ddbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evj ARSENITE
METHYLTRANSFERASE

(Chlamydomonas
reinhardtii) 		PF13847
(Methyltransf_31) 		5 GLY A 218
LEU A 206
VAL A 261
ILE A 252
LEU A 174
 None
 1.17A 3g9eA-5evjA:
undetectable		 3g9eA-5evjA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		5 GLY D 255
LEU D 296
VAL D 270
LEU D 231
TYR D 235
 None
 1.16A 3g9eA-5exrD:
undetectable		 3g9eA-5exrD:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		5 GLY A 221
SER A 187
LEU A 158
ILE A 218
HIS A 238
 None
None
None
None
ZN  A2001 (-3.6A)
 1.25A 3g9eA-5fb3A:
undetectable		 3g9eA-5fb3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 GLY A 126
SER A 131
LEU A  18
VAL A  44
LEU A 173
 None
 1.24A 3g9eA-5ha5A:
undetectable		 3g9eA-5ha5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		5 HIS A 224
TYR A 679
LEU A 678
ILE A 604
LEU A 210
 None
 1.20A 3g9eA-5idoA:
undetectable		 3g9eA-5idoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig9 ATP GRASP LIGASE

(Microcystis
aeruginosa) 		no annotation 5 HIS A 112
LEU A 321
VAL A  18
ILE A  19
LEU A 108
 None
 1.19A 3g9eA-5ig9A:
undetectable		 3g9eA-5ig9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j8q CYSTEINE DESULFURASE
SUFS

(Bacillus
subtilis) 		PF00266
(Aminotran_5) 		5 GLY A 199
HIS A 223
LEU A 284
VAL A  74
ILE A  78
 None
PLP  A 501 (-3.9A)
None
None
None
 1.11A 3g9eA-5j8qA:
undetectable		 3g9eA-5j8qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 GLY B  75
HIS B 128
LEU B 204
VAL B 108
ILE B 224
 None
 1.08A 3g9eA-5osnB:
undetectable		 3g9eA-5osnB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		5 GLY B  75
LEU B 204
VAL B 108
ILE B 224
HIS B 128
 None
 1.09A 3g9eA-5osnB:
undetectable		 3g9eA-5osnB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 5 CYH A 220
SER A 218
HIS A 210
TYR A 233
LEU A 208
 None
 1.23A 3g9eA-5tiwA:
undetectable		 3g9eA-5tiwA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 5 GLY D 144
LEU D 297
ILE D 174
LEU B 108
TYR B 109
 None
 1.14A 3g9eA-5uz5D:
undetectable		 3g9eA-5uz5D:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 HIS A 396
LEU A 398
VAL A 215
ILE A 316
TYR A 534
 None
 1.24A 3g9eA-5w1uA:
undetectable		 3g9eA-5w1uA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 HIS A 396
VAL A 215
ILE A 316
LEU A 539
TYR A 534
 None
 1.24A 3g9eA-5w1uA:
undetectable		 3g9eA-5w1uA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 GLY A 743
TYR A1156
LEU A1159
ILE A 862
LEU A 759
 None
 0.93A 3g9eA-5xvmA:
undetectable		 3g9eA-5xvmA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 SER A  98
LEU A 116
VAL A 205
LEU A  52
TYR A  50
 None
 1.08A 3g9eA-6ap6A:
undetectable		 3g9eA-6ap6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 GLY A 209
HIS A 233
LEU A 294
VAL A  84
ILE A  88
 None
LLP  A 234 ( 3.7A)
None
None
None
 1.17A 3g9eA-6c9eA:
undetectable		 3g9eA-6c9eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 GLY A 246
HIS A 199
LEU A 223
VAL A 218
ILE A  88
 None
 1.23A 3g9eA-6c9eA:
undetectable		 3g9eA-6c9eA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fju -

(-) 		no annotation 5 GLY A  50
TYR A  82
LEU A  28
VAL A  65
HIS A  16
 None
 1.25A 3g9eA-6fjuA:
undetectable		 3g9eA-6fjuA:
undetectable