SIMILAR PATTERNS OF AMINO ACIDS FOR 3G8I_A_RO7A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		5 TYR A 100
ILE A  33
ILE A  56
HIS A  69
VAL A  67
 None
 1.09A 3g8iA-1e09A:
undetectable		 3g8iA-1e09A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A 477
ILE A 452
ILE A  33
HIS A  29
TYR A 367
 None
 1.24A 3g8iA-1e43A:
0.0		 3g8iA-1e43A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 VAL A 223
TYR A  65
ILE A 219
VAL A 163
TYR A 125
 None
None
PCA  A   1 ( 4.6A)
None
None
 1.25A 3g8iA-1jaeA:
0.0		 3g8iA-1jaeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 347
SER A  53
MET A 386
ILE A 367
VAL A  49
 None
 1.16A 3g8iA-1jr1A:
undetectable		 3g8iA-1jr1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 VAL A 234
TYR A  67
ILE A 230
VAL A 175
TYR A 131
 None
None
PCA  A   1 ( 4.5A)
None
None
 1.25A 3g8iA-1jxkA:
0.0		 3g8iA-1jxkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		5 TYR A 392
ILE A  63
ILE A 314
MET A  39
HIS A 318
 None
 1.44A 3g8iA-1k7hA:
undetectable		 3g8iA-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		5 VAL A 223
TYR A 168
ILE A 319
HIS A 166
VAL A 197
 None
 1.39A 3g8iA-1khwA:
0.0		 3g8iA-1khwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 813
ILE A 619
ILE A 152
VAL A 149
TYR A 316
 None
 1.37A 3g8iA-2gv9A:
0.0		 3g8iA-2gv9A:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.67A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 CYH A 275
CYH A 276
TYR A 314
MET A 330
ILE A 339
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.87A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 SER A 280
TYR A 314
MET A 325
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-2.8A)
735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.24A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 TYR A 314
MET A 325
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.11A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 255
CYH A 275
CYH A 276
ILE A 354
TYR A 314
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.7A)
735  A 469 (-3.9A)
 1.33A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 VAL A 255
CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
VAL A 444
TYR A 464
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.78A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v65 L-LACTATE
DEHYDROGENASE A
CHAIN

(Champsocephalus
gunnari) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 281
MET A 305
ILE A 191
HIS A 229
VAL A 233
 None
 1.34A 3g8iA-2v65A:
0.0		 3g8iA-2v65A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 VAL A  24
SER A 277
ILE A  42
ILE A  86
TYR A 386
 None
UDP  A1477 (-2.5A)
EDO  A1483 (-4.8A)
EDO  A1480 (-4.9A)
None
 1.26A 3g8iA-2vg8A:
undetectable		 3g8iA-2vg8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL B 278
SER B 266
ILE B 333
ILE B 338
VAL B 312
 None
 1.35A 3g8iA-3a79B:
undetectable		 3g8iA-3a79B:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
SER A 289
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 0.92A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 SER A 289
MET A 334
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-2.6A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 1.27A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 VAL A  32
MET A  39
ILE A  37
ILE A  56
HIS A 408
 None
 1.27A 3g8iA-3bs8A:
undetectable		 3g8iA-3bs8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 CYH A 310
SER A 343
MET A  13
ILE A 336
VAL A 399
 None
None
None
None
P33  A 439 ( 4.0A)
 1.40A 3g8iA-3cc1A:
undetectable		 3g8iA-3cc1A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 SER D 289
MET D 334
MET D 364
HIS D 449
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
 1.33A 3g8iA-3dzuD:
34.3		 3g8iA-3dzuD:
61.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 CYH A 163
SER A 159
TYR A 359
ILE A 167
ILE A  62
 None
 1.40A 3g8iA-3eb0A:
undetectable		 3g8iA-3eb0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 CYH A 163
SER A 159
TYR A 359
ILE A 228
ILE A  62
 None
 1.19A 3g8iA-3eb0A:
undetectable		 3g8iA-3eb0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 VAL A1219
SER A1293
TYR A1706
ILE A1228
TYR A1715
 None
 1.38A 3g8iA-3hmjA:
undetectable		 3g8iA-3hmjA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 214
CYH A 244
CYH A 245
MET A  35
HIS A 221
 None
 1.31A 3g8iA-3komA:
undetectable		 3g8iA-3komA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 SER A  60
ILE A  85
ILE A  36
HIS A  40
TYR A  51
 None
 1.25A 3g8iA-3mzsA:
undetectable		 3g8iA-3mzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 VAL B 473
ILE A 195
ILE B 381
VAL B 373
TYR B 300
 None
 1.28A 3g8iA-3ojyB:
undetectable		 3g8iA-3ojyB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa8 TOXIN B

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		5 VAL A  63
ILE A 143
ILE A 180
MET A 184
VAL A 176
 None
 1.15A 3g8iA-3pa8A:
undetectable		 3g8iA-3pa8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		5 VAL A 600
CYH A 598
CYH A 597
MET A 575
ILE A 642
 None
 1.48A 3g8iA-3q6mA:
undetectable		 3g8iA-3q6mA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 401
TYR A 352
MET A 365
ILE A 372
ILE A 386
 None
 1.47A 3g8iA-3ue3A:
undetectable		 3g8iA-3ue3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uo7 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		5 VAL A 247
ILE A 237
ILE A 137
MET A 192
VAL A 135
 None
 1.42A 3g8iA-3uo7A:
undetectable		 3g8iA-3uo7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 VAL A 244
ILE A 217
ILE A 221
VAL A 257
TYR A 163
 None
GOL  A 410 ( 4.0A)
None
None
None
 1.28A 3g8iA-3wq1A:
undetectable		 3g8iA-3wq1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		5 VAL A 288
CYH A 221
ILE A 297
VAL A 190
TYR A 173
 None
 1.45A 3g8iA-4eljA:
undetectable		 3g8iA-4eljA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		5 VAL A  73
CYH A 124
MET A 132
ILE A  87
ILE A 142
 None
 1.45A 3g8iA-4iuyA:
undetectable		 3g8iA-4iuyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A  49
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.27A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A 138
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.25A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		5 VAL A 294
SER A 149
ILE A  86
VAL A 169
TYR A 193
 None
 1.15A 3g8iA-4qx8A:
undetectable		 3g8iA-4qx8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 VAL A  71
CYH A 122
MET A 130
ILE A  85
ILE A 139
 None
 1.35A 3g8iA-4rzhA:
undetectable		 3g8iA-4rzhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 212
CYH A 241
CYH A 242
HIS A 219
VAL A 245
 None
 1.23A 3g8iA-4xeuA:
undetectable		 3g8iA-4xeuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 SER A 523
TYR A 716
ILE A 492
ILE A 788
VAL A 735
 None
 1.21A 3g8iA-5c2vA:
undetectable		 3g8iA-5c2vA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 VAL A 139
CYH A 190
SER A 188
TYR A  62
MET A 154
 PE3  A 303 (-4.8A)
PE3  A 303 ( 4.1A)
None
None
None
 1.22A 3g8iA-5cbkA:
undetectable		 3g8iA-5cbkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 VAL A 897
CYH A1013
CYH A1012
ILE A 629
VAL A 627
 None
 0.93A 3g8iA-5d0fA:
undetectable		 3g8iA-5d0fA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 VAL A 290
SER A 354
ILE A 187
VAL A 366
TYR A 368
 VAL  A 290 ( 0.6A)
SER  A 354 ( 0.0A)
ILE  A 187 ( 0.7A)
VAL  A 366 ( 0.6A)
TYR  A 368 ( 1.3A)
 0.99A 3g8iA-5gprA:
undetectable		 3g8iA-5gprA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 SER A 312
ILE A 448
ILE A 356
VAL A 318
TYR A 326
 None
 1.41A 3g8iA-5ikzA:
undetectable		 3g8iA-5ikzA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 VAL A  17
CYH A1421
SER A 859
ILE A1429
ILE A1436
 None
 1.47A 3g8iA-5ip9A:
undetectable		 3g8iA-5ip9A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 5 VAL A 159
ILE A 165
HIS A  28
VAL A  33
TYR A  34
 None
 1.26A 3g8iA-5o82A:
undetectable		 3g8iA-5o82A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 VAL A 182
CYH A 266
ILE A 169
ILE A 158
VAL A 119
 None
 1.44A 3g8iA-5tv2A:
undetectable		 3g8iA-5tv2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xna SAHS1

(Ramazzottius
varieornatus) 		no annotation 5 TYR A 117
ILE A  54
ILE A  85
HIS A  83
VAL A  96
 EDO  A 207 (-4.6A)
None
None
None
None
 1.46A 3g8iA-5xnaA:
undetectable		 3g8iA-5xnaA:
17.56