SIMILAR PATTERNS OF AMINO ACIDS FOR 3G8I_A_RO7A1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e09 PRU AV 1

(Prunus avium) 		PF00407
(Bet_v_1) 		5 TYR A 100
ILE A  33
ILE A  56
HIS A  69
VAL A  67
 None
 1.09A 3g8iA-1e09A:
undetectable		 3g8iA-1e09A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e43 ALPHA-AMYLASE

(Bacillus
amyloliquefaciens) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 VAL A 477
ILE A 452
ILE A  33
HIS A  29
TYR A 367
 None
 1.24A 3g8iA-1e43A:
0.0		 3g8iA-1e43A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 VAL A 223
TYR A  65
ILE A 219
VAL A 163
TYR A 125
 None
None
PCA  A   1 ( 4.6A)
None
None
 1.25A 3g8iA-1jaeA:
0.0		 3g8iA-1jaeA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 VAL A 347
SER A  53
MET A 386
ILE A 367
VAL A  49
 None
 1.16A 3g8iA-1jr1A:
undetectable		 3g8iA-1jr1A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jxk ALPHA-AMYLASE,
SALIVARY

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 VAL A 234
TYR A  67
ILE A 230
VAL A 175
TYR A 131
 None
None
PCA  A   1 ( 4.5A)
None
None
 1.25A 3g8iA-1jxkA:
0.0		 3g8iA-1jxkA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		5 TYR A 392
ILE A  63
ILE A 314
MET A  39
HIS A 318
 None
 1.44A 3g8iA-1k7hA:
undetectable		 3g8iA-1k7hA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		5 VAL A 223
TYR A 168
ILE A 319
HIS A 166
VAL A 197
 None
 1.39A 3g8iA-1khwA:
0.0		 3g8iA-1khwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gv9 DNA POLYMERASE

(Human
alphaherpesvirus
1) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 813
ILE A 619
ILE A 152
VAL A 149
TYR A 316
 None
 1.37A 3g8iA-2gv9A:
0.0		 3g8iA-2gv9A:
13.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.67A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 CYH A 275
CYH A 276
TYR A 314
MET A 330
ILE A 339
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.87A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 SER A 280
TYR A 314
MET A 325
ILE A 354
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-2.8A)
735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.24A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 TYR A 314
MET A 325
ILE A 354
MET A 355
HIS A 440
VAL A 444
TYR A 464
 735  A 469 (-3.9A)
None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 1.11A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 VAL A 255
CYH A 275
CYH A 276
ILE A 354
TYR A 314
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-3.7A)
735  A 469 (-3.9A)
 1.33A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 VAL A 255
CYH A 275
CYH A 276
SER A 280
TYR A 314
MET A 330
ILE A 339
ILE A 354
VAL A 444
TYR A 464
 735  A 469 (-4.0A)
735  A 469 ( 4.0A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-3.9A)
735  A 469 ( 3.2A)
735  A 469 ( 4.1A)
735  A 469 (-3.7A)
735  A 469 ( 3.9A)
735  A 469 (-4.6A)
 0.78A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v65 L-LACTATE
DEHYDROGENASE A
CHAIN

(Champsocephalus
gunnari) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 281
MET A 305
ILE A 191
HIS A 229
VAL A 233
 None
 1.34A 3g8iA-2v65A:
0.0		 3g8iA-2v65A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg8 HYDROQUINONE
GLUCOSYLTRANSFERASE

(Arabidopsis
thaliana) 		PF00201
(UDPGT) 		5 VAL A  24
SER A 277
ILE A  42
ILE A  86
TYR A 386
 None
UDP  A1477 (-2.5A)
EDO  A1483 (-4.8A)
EDO  A1480 (-4.9A)
None
 1.26A 3g8iA-2vg8A:
undetectable		 3g8iA-2vg8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 VAL B 278
SER B 266
ILE B 333
ILE B 338
VAL B 312
 None
 1.35A 3g8iA-3a79B:
undetectable		 3g8iA-3a79B:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 285
SER A 289
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 0.92A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 SER A 289
MET A 334
MET A 364
HIS A 449
TYR A 473
 MC5  A   1 (-2.6A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 1.27A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 VAL A  32
MET A  39
ILE A  37
ILE A  56
HIS A 408
 None
 1.27A 3g8iA-3bs8A:
undetectable		 3g8iA-3bs8A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		5 CYH A 310
SER A 343
MET A  13
ILE A 336
VAL A 399
 None
None
None
None
P33  A 439 ( 4.0A)
 1.40A 3g8iA-3cc1A:
undetectable		 3g8iA-3cc1A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 SER D 289
MET D 334
MET D 364
HIS D 449
TYR D 473
 PLB  D 701 ( 3.9A)
None
PLB  D 701 ( 4.8A)
None
None
 1.33A 3g8iA-3dzuD:
34.3		 3g8iA-3dzuD:
61.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 CYH A 163
SER A 159
TYR A 359
ILE A 167
ILE A  62
 None
 1.40A 3g8iA-3eb0A:
undetectable		 3g8iA-3eb0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 CYH A 163
SER A 159
TYR A 359
ILE A 228
ILE A  62
 None
 1.19A 3g8iA-3eb0A:
undetectable		 3g8iA-3eb0A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 VAL A1219
SER A1293
TYR A1706
ILE A1228
TYR A1715
 None
 1.38A 3g8iA-3hmjA:
undetectable		 3g8iA-3hmjA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kom TRANSKETOLASE

(Francisella
tularensis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 214
CYH A 244
CYH A 245
MET A  35
HIS A 221
 None
 1.31A 3g8iA-3komA:
undetectable		 3g8iA-3komA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzs CHOLESTEROL
SIDE-CHAIN CLEAVAGE
ENZYME

(Bos taurus) 		PF00067
(p450) 		5 SER A  60
ILE A  85
ILE A  36
HIS A  40
TYR A  51
 None
 1.25A 3g8iA-3mzsA:
undetectable		 3g8iA-3mzsA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 ALPHA CHAIN
COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 VAL B 473
ILE A 195
ILE B 381
VAL B 373
TYR B 300
 None
 1.28A 3g8iA-3ojyB:
undetectable		 3g8iA-3ojyB:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pa8 TOXIN B

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		5 VAL A  63
ILE A 143
ILE A 180
MET A 184
VAL A 176
 None
 1.15A 3g8iA-3pa8A:
undetectable		 3g8iA-3pa8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6m HEAT SHOCK PROTEIN
HSP 90-ALPHA

(Homo sapiens) 		PF00183
(HSP90) 		5 VAL A 600
CYH A 598
CYH A 597
MET A 575
ILE A 642
 None
 1.48A 3g8iA-3q6mA:
undetectable		 3g8iA-3q6mA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 SER A 401
TYR A 352
MET A 365
ILE A 372
ILE A 386
 None
 1.47A 3g8iA-3ue3A:
undetectable		 3g8iA-3ue3A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uo7 G/T
MISMATCH-SPECIFIC
THYMINE DNA
GLYCOSYLASE

(Homo sapiens) 		PF03167
(UDG) 		5 VAL A 247
ILE A 237
ILE A 137
MET A 192
VAL A 135
 None
 1.42A 3g8iA-3uo7A:
undetectable		 3g8iA-3uo7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq1 ENDOGLUCANASE A

(Pyrococcus
furiosus) 		PF01670
(Glyco_hydro_12) 		5 VAL A 244
ILE A 217
ILE A 221
VAL A 257
TYR A 163
 None
GOL  A 410 ( 4.0A)
None
None
None
 1.28A 3g8iA-3wq1A:
undetectable		 3g8iA-3wq1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elj RETINOBLASTOMA-ASSOC
IATED PROTEIN

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A)
PF11934
(DUF3452) 		5 VAL A 288
CYH A 221
ILE A 297
VAL A 190
TYR A 173
 None
 1.45A 3g8iA-4eljA:
undetectable		 3g8iA-4eljA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuy SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE

(Acinetobacter
baumannii) 		PF00106
(adh_short) 		5 VAL A  73
CYH A 124
MET A 132
ILE A  87
ILE A 142
 None
 1.45A 3g8iA-4iuyA:
undetectable		 3g8iA-4iuyA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 MET A  49
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.27A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qae NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		PF00061
(Lipocalin) 		5 TYR A 138
ILE A  68
MET A  70
VAL A  66
TYR A  56
 None
 1.25A 3g8iA-4qaeA:
undetectable		 3g8iA-4qaeA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qx8 LYSINE-SPECIFIC
DEMETHYLASE 2A

(Mus musculus) 		PF02373
(JmjC) 		5 VAL A 294
SER A 149
ILE A  86
VAL A 169
TYR A 193
 None
 1.15A 3g8iA-4qx8A:
undetectable		 3g8iA-4qx8A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzh 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Synechocystis
sp. PCC 6803) 		PF13561
(adh_short_C2) 		5 VAL A  71
CYH A 122
MET A 130
ILE A  85
ILE A 139
 None
 1.35A 3g8iA-4rzhA:
undetectable		 3g8iA-4rzhA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 VAL A 212
CYH A 241
CYH A 242
HIS A 219
VAL A 245
 None
 1.23A 3g8iA-4xeuA:
undetectable		 3g8iA-4xeuA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 SER A 523
TYR A 716
ILE A 492
ILE A 788
VAL A 735
 None
 1.21A 3g8iA-5c2vA:
undetectable		 3g8iA-5c2vA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		5 VAL A 139
CYH A 190
SER A 188
TYR A  62
MET A 154
 PE3  A 303 (-4.8A)
PE3  A 303 ( 4.1A)
None
None
None
 1.22A 3g8iA-5cbkA:
undetectable		 3g8iA-5cbkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 VAL A 897
CYH A1013
CYH A1012
ILE A 629
VAL A 627
 None
 0.93A 3g8iA-5d0fA:
undetectable		 3g8iA-5d0fA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		5 VAL A 290
SER A 354
ILE A 187
VAL A 366
TYR A 368
 VAL  A 290 ( 0.6A)
SER  A 354 ( 0.0A)
ILE  A 187 ( 0.7A)
VAL  A 366 ( 0.6A)
TYR  A 368 ( 1.3A)
 0.99A 3g8iA-5gprA:
undetectable		 3g8iA-5gprA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1

(Burkholderia
thailandensis) 		PF05853
(BKACE) 		5 SER A 312
ILE A 448
ILE A 356
VAL A 318
TYR A 326
 None
 1.41A 3g8iA-5ikzA:
undetectable		 3g8iA-5ikzA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 VAL A  17
CYH A1421
SER A 859
ILE A1429
ILE A1436
 None
 1.47A 3g8iA-5ip9A:
undetectable		 3g8iA-5ip9A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 5 VAL A 159
ILE A 165
HIS A  28
VAL A  33
TYR A  34
 None
 1.26A 3g8iA-5o82A:
undetectable		 3g8iA-5o82A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 VAL A 182
CYH A 266
ILE A 169
ILE A 158
VAL A 119
 None
 1.44A 3g8iA-5tv2A:
undetectable		 3g8iA-5tv2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xna SAHS1

(Ramazzottius
varieornatus) 		no annotation 5 TYR A 117
ILE A  54
ILE A  85
HIS A  83
VAL A  96
 EDO  A 207 (-4.6A)
None
None
None
None
 1.46A 3g8iA-5xnaA:
undetectable		 3g8iA-5xnaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0n PROTEIN (SINR
PROTEIN)

(Bacillus
subtilis) 		PF01381
(HTH_3)
PF08671
(SinI) 		4 GLN A  45
LEU A  61
VAL A  53
LEU A  31
 None
 0.95A 3g8iA-1b0nA:
undetectable		 3g8iA-1b0nA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0u HISTIDINE PERMEASE

(Salmonella
enterica) 		PF00005
(ABC_tran) 		4 LEU A 199
LEU A  27
VAL A 208
LEU A  91
 None
 0.94A 3g8iA-1b0uA:
undetectable		 3g8iA-1b0uA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 135
LEU A 204
VAL A 181
LEU A 169
 None
 0.70A 3g8iA-1d0bA:
undetectable		 3g8iA-1d0bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et9 SUPERANTIGEN SPE-H

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU A 161
GLN A 128
LEU A 171
LEU A  71
 None
 0.75A 3g8iA-1et9A:
undetectable		 3g8iA-1et9A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		4 LEU A 487
GLN A 366
LEU A 355
VAL A 374
 None
 0.84A 3g8iA-1fchA:
0.0		 3g8iA-1fchA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fzq ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
3

(Mus musculus) 		PF00025
(Arf) 		4 LEU A  37
GLN A 154
LEU A 107
VAL A  91
 None
MES  A 201 (-4.0A)
None
None
 0.92A 3g8iA-1fzqA:
undetectable		 3g8iA-1fzqA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		4 LEU A 156
VAL A 223
LEU A 176
LEU A 349
 None
 0.73A 3g8iA-1ij5A:
0.0		 3g8iA-1ij5A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j83 ENDO-1,4-BETA
GLUCANASE ENGF

(Clostridium
cellulovorans) 		PF03424
(CBM_17_28) 		4 LEU A1069
VAL A1051
LEU A1074
LEU A1110
 None
 0.82A 3g8iA-1j83A:
undetectable		 3g8iA-1j83A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9s INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF09479
(Flg_new)
PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13457
(SH3_8) 		4 LEU A 135
LEU A 204
VAL A 181
LEU A 169
 None
 0.68A 3g8iA-1m9sA:
undetectable		 3g8iA-1m9sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 LEU A 213
LEU A 190
LEU A 249
LEU A 150
 None
 0.74A 3g8iA-1nbwA:
0.0		 3g8iA-1nbwA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A  98
VAL A 199
LEU A  93
LEU A  11
 None
 0.87A 3g8iA-1oypA:
0.0		 3g8iA-1oypA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 LEU A 286
LEU A 301
VAL A 281
LEU A 338
 None
 0.92A 3g8iA-1pbyA:
undetectable		 3g8iA-1pbyA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pe9 PECTATE LYASE A

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		4 LEU A 105
GLN A  58
VAL A 116
LEU A   3
 None
 0.95A 3g8iA-1pe9A:
undetectable		 3g8iA-1pe9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q32 TYROSYL-DNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 293
LEU A 199
VAL A 271
LEU A 222
 None
 0.82A 3g8iA-1q32A:
undetectable		 3g8iA-1q32A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1)
no annotation 		4 LEU E 292
LEU D 164
LEU E 247
LEU D 134
 None
 0.94A 3g8iA-1qgeE:
undetectable		 3g8iA-1qgeE:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qw2 CONSERVED
HYPOTHETICAL PROTEIN
TA1206

(Thermoplasma
acidophilum) 		PF08827
(DUF1805) 		4 GLN A  94
LEU A  60
VAL A  89
LEU A 114
 None
 0.91A 3g8iA-1qw2A:
undetectable		 3g8iA-1qw2A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 LEU A 284
LEU A 169
VAL A 172
LEU A 147
 None
 0.86A 3g8iA-1uagA:
undetectable		 3g8iA-1uagA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 LEU A 167
VAL A 259
LEU A 250
LEU A 186
 None
 0.75A 3g8iA-1w27A:
undetectable		 3g8iA-1w27A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A 155
VAL A 355
LEU A 236
LEU A 270
 None
 0.83A 3g8iA-1ykwA:
undetectable		 3g8iA-1ykwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbu 3'-5' EXONUCLEASE
ERI1

(Homo sapiens) 		PF00929
(RNase_T) 		4 LEU A 239
GLN A 343
VAL A 210
LEU A 227
 None
 0.83A 3g8iA-1zbuA:
undetectable		 3g8iA-1zbuA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF00515
(TPR_1)
PF13432
(TPR_16) 		4 LEU A 524
GLN A 403
LEU A 392
VAL A 411
 None
 0.82A 3g8iA-2c0lA:
undetectable		 3g8iA-2c0lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlz PROTEIN VAV-2

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A  31
LEU A 104
VAL A  62
LEU A  88
 None
 0.94A 3g8iA-2dlzA:
undetectable		 3g8iA-2dlzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dm0 TYROSINE-PROTEIN
KINASE TXK

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A  95
LEU A  32
VAL A  43
LEU A 110
 None
 0.67A 3g8iA-2dm0A:
undetectable		 3g8iA-2dm0A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekx CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A  90
LEU A  27
VAL A  38
LEU A 105
 None
 0.78A 3g8iA-2ekxA:
undetectable		 3g8iA-2ekxA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 LEU A 153
VAL A   3
LEU A 148
LEU A 108
 None
 0.80A 3g8iA-2gr9A:
undetectable		 3g8iA-2gr9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		4 GLN A  61
LEU A  47
VAL A  41
LEU A  93
 None
 0.93A 3g8iA-2h1yA:
undetectable		 3g8iA-2h1yA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2je1 ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER A

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A  34
LEU A 112
VAL A  82
LEU A 120
 None
 0.91A 3g8iA-2je1A:
undetectable		 3g8iA-2je1A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5w DATP
PYROPHOSPHOHYDROLASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 LEU A  70
GLN A 112
LEU A  27
VAL A  57
 None
 0.76A 3g8iA-2o5wA:
undetectable		 3g8iA-2o5wA:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 247
GLN A 277
LEU A 321
VAL A 332
LEU A 344
LYS A 358
LEU A 460
 None
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-3.8A)
735  A 469 ( 4.2A)
None
735  A 469 (-4.3A)
 0.64A 3g8iA-2p54A:
40.0		 3g8iA-2p54A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pid TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLN A 225
LEU A  98
VAL A 170
LEU A  87
 YSA  A 384 (-3.3A)
None
None
None
 0.86A 3g8iA-2pidA:
undetectable		 3g8iA-2pidA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px0 FLAGELLAR
BIOSYNTHESIS PROTEIN
FLHF

(Bacillus
subtilis) 		PF00448
(SRP54) 		4 LEU A 325
VAL A 355
LEU A 332
LEU A 180
 None
 0.82A 3g8iA-2px0A:
undetectable		 3g8iA-2px0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 LEU A 270
GLN A 247
LEU A 206
LEU A 214
 None
 0.95A 3g8iA-2q7sA:
undetectable		 3g8iA-2q7sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6

(Homo sapiens) 		PF00017
(SH2) 		4 LEU A 457
LEU A 398
VAL A 408
LEU A 487
 None
 0.94A 3g8iA-2vifA:
undetectable		 3g8iA-2vifA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxz ANGIOTENSINOGEN

(Rattus
norvegicus) 		PF00079
(Serpin) 		4 LEU A 371
LEU A 177
VAL A 391
LEU A 378
 None
 0.95A 3g8iA-2wxzA:
undetectable		 3g8iA-2wxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y5q INTERNALIN B

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 135
LEU A 204
VAL A 181
LEU A 169
 None
 0.67A 3g8iA-2y5qA:
undetectable		 3g8iA-2y5qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 GLN A 851
LEU A 860
VAL A 875
LEU A 898
 None
 0.95A 3g8iA-2yd0A:
undetectable		 3g8iA-2yd0A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 LEU A 317
VAL A  96
LEU A 388
LEU A 116
 None
NHW  A1000 ( 4.0A)
YNE  A1001 (-4.2A)
None
 0.92A 3g8iA-2yneA:
undetectable		 3g8iA-2yneA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 LEU A  60
LEU A 141
LEU A  70
LEU A 171
 None
None
None
NAP  A 500 (-3.5A)
 0.92A 3g8iA-2yutA:
undetectable		 3g8iA-2yutA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgh GRANZYME M

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 107
GLN A  91
LEU A  54
VAL A  29
 None
 0.74A 3g8iA-2zghA:
undetectable		 3g8iA-2zghA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 158
VAL A 142
LEU A 188
LEU A 104
 None
 0.89A 3g8iA-2zyjA:
undetectable		 3g8iA-2zyjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1t IRON(II) TRANSPORT
PROTEIN B

(Thermotoga
maritima) 		PF02421
(FeoB_N) 		4 LEU A  76
LEU A  67
VAL A  98
LYS A  54
 None
 0.89A 3g8iA-3a1tA:
1.3		 3g8iA-3a1tA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 286
LEU A 330
LEU A 353
LYS A 367
LEU A 469
 None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
None
MC5  A   1 (-4.1A)
 0.72A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
GLN A 286
LEU A 330
LEU A 353
LYS A 367
 None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.7A)
None
 0.92A 3g8iA-3b0qA:
36.7		 3g8iA-3b0qA:
61.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5e MLL8374 PROTEIN

(Mesorhizobium
japonicum) 		no annotation 4 LEU A  35
LEU A 155
VAL A 135
LEU A 140
 None
 0.95A 3g8iA-3b5eA:
undetectable		 3g8iA-3b5eA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 170
LEU A 162
LEU A 226
LEU A 275
 None
 0.89A 3g8iA-3b97A:
undetectable		 3g8iA-3b97A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 GLN A  33
VAL A  40
LEU A  18
LYS A  75
 None
 0.95A 3g8iA-3cb5A:
undetectable		 3g8iA-3cb5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36
VACUOLAR-SORTING
PROTEIN SNF8

(Homo sapiens) 		PF04157
(EAP30) 		4 LEU B 249
LEU B 352
LEU B 257
LEU A 109
 None
 0.91A 3g8iA-3cuqB:
undetectable		 3g8iA-3cuqB:
24.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN A 286
LEU A 330
VAL A 341
LYS A 367
 None
L41  A 501 (-4.9A)
L41  A 501 ( 4.4A)
None
 0.88A 3g8iA-3d5fA:
38.0		 3g8iA-3d5fA:
70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLN A 286
VAL A 341
LYS A 367
LEU A 469
 None
L41  A 501 ( 4.4A)
None
L41  A 501 (-3.8A)
 0.56A 3g8iA-3d5fA:
38.0		 3g8iA-3d5fA:
70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
GLN A 286
LEU A 330
VAL A 341
LEU A 353
 None
None
L41  A 501 (-4.9A)
L41  A 501 ( 4.4A)
None
 0.70A 3g8iA-3d5fA:
38.0		 3g8iA-3d5fA:
70.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
GLN A 286
VAL A 341
LEU A 353
LEU A 469
 None
None
L41  A 501 ( 4.4A)
None
L41  A 501 (-3.8A)
 0.60A 3g8iA-3d5fA:
38.0		 3g8iA-3d5fA:
70.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtt NADP OXIDOREDUCTASE

(Arthrobacter
sp. FB24) 		PF03807
(F420_oxidored) 		4 LEU A 126
VAL A 139
LEU A  88
LEU A  19
 None
 0.87A 3g8iA-3dttA:
undetectable		 3g8iA-3dttA:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 LEU D 255
GLN D 286
LEU D 330
LEU D 353
LEU D 469
 None
None
PLB  D 701 ( 4.1A)
None
None
 0.72A 3g8iA-3dzuD:
34.3		 3g8iA-3dzuD:
61.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gra TRANSCRIPTIONAL
REGULATOR, ARAC
FAMILY

(Pseudomonas
putida) 		PF01965
(DJ-1_PfpI) 		4 LEU A 199
LEU A 131
LEU A  52
LEU A 118
 None
 0.90A 3g8iA-3graA:
undetectable		 3g8iA-3graA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 LEU A  23
LEU A 325
VAL A   7
LEU A 311
 None
 0.88A 3g8iA-3hidA:
undetectable		 3g8iA-3hidA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		4 LEU 2 154
LEU 2 125
VAL 2 142
LEU 2  96
 None
FES  2 182 (-4.8A)
None
None
 0.88A 3g8iA-3i9v2:
undetectable		 3g8iA-3i9v2:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		4 LEU A 312
LEU A  21
VAL A 299
LEU A 109
 None
 0.95A 3g8iA-3qatA:
undetectable		 3g8iA-3qatA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 LEU A 166
VAL A 478
LEU A 403
LEU A 503
 None
 0.89A 3g8iA-3rcnA:
undetectable		 3g8iA-3rcnA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1

(Saccharomyces
cerevisiae) 		PF06087
(Tyr-DNA_phospho) 		4 LEU A 293
LEU A 199
VAL A 271
LEU A 222
 None
 0.77A 3g8iA-3sq7A:
undetectable		 3g8iA-3sq7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zc4 SSO1398

(Sulfolobus
solfataricus) 		no annotation 4 LEU A  54
VAL A 136
LEU A 154
LEU A  86
 None
 0.86A 3g8iA-3zc4A:
undetectable		 3g8iA-3zc4A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		4 LEU X 269
VAL X 295
LEU X 306
LEU X 195
 None
 0.88A 3g8iA-3zyyX:
undetectable		 3g8iA-3zyyX:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		4 LEU I 269
VAL I 295
LEU I 306
LEU I 195
 None
 0.81A 3g8iA-4c1nI:
undetectable		 3g8iA-4c1nI:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2s UREIDOGLYCINE
AMINOHYDROLASE

(Arabidopsis
thaliana) 		PF07883
(Cupin_2) 		4 LEU A 125
VAL A 188
LEU A 161
LEU A 246
 None
 0.77A 3g8iA-4e2sA:
undetectable		 3g8iA-4e2sA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		4 GLN A 154
LEU A 202
LEU A 149
LEU A 269
 None
 0.96A 3g8iA-4fznA:
undetectable		 3g8iA-4fznA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqz PUTATIVE PERIPLASMIC
OR EXPORTED PROTEIN

(Salmonella
enterica) 		no annotation 4 LEU A  54
GLN A  40
LEU A  78
LEU A  67
 None
 0.77A 3g8iA-4gqzA:
undetectable		 3g8iA-4gqzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A 290
LEU A  43
LEU A  20
LEU A  76
 None
 0.92A 3g8iA-4kegA:
undetectable		 3g8iA-4kegA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		4 LEU A 268
LEU A 110
VAL A 208
LEU A 163
 None
 0.94A 3g8iA-4l5iA:
undetectable		 3g8iA-4l5iA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li2 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Xenopus
tropicalis) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 287
GLN A 296
LEU A 324
LEU A 329
 None
 0.93A 3g8iA-4li2A:
undetectable		 3g8iA-4li2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9q FMN-DEPENDENT
NADH-AZOREDUCTASE 1

(Pseudomonas
aeruginosa) 		PF02525
(Flavodoxin_2) 		4 GLN A 112
LEU A   5
LEU A 171
LEU A  77
 None
 0.92A 3g8iA-4n9qA:
undetectable		 3g8iA-4n9qA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		4 LEU A 291
LEU A  44
LEU A  21
LEU A  77
 None
 0.95A 3g8iA-4o2xA:
undetectable		 3g8iA-4o2xA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		4 LEU A 326
LEU A 349
LEU A 357
LEU A  92
 None
 0.84A 3g8iA-4on1A:
undetectable		 3g8iA-4on1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p98 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Conexibacter
woesei) 		PF02608
(Bmp) 		4 LEU A 229
LEU A 309
LEU A 219
LEU A 288
 None
 0.96A 3g8iA-4p98A:
undetectable		 3g8iA-4p98A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3i OSSERK2 D128N

(Oryza sativa) 		PF08263
(LRRNT_2)
PF11921
(DUF3439) 		4 LEU A  52
GLN A  93
LEU A 121
LEU A 105
 None
 0.92A 3g8iA-4q3iA:
undetectable		 3g8iA-4q3iA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 LEU A 403
LEU A 559
VAL A 429
LEU A 575
 None
 0.89A 3g8iA-4ql6A:
undetectable		 3g8iA-4ql6A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6j LUCINE RICH REPEATS
DLRR_H

(synthetic
construct) 		PF00560
(LRR_1)
PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 GLN A 229
LEU A 235
VAL A 207
LEU A 219
 None
 0.86A 3g8iA-4r6jA:
undetectable		 3g8iA-4r6jA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 LEU A 273
VAL A 225
LEU A 216
LEU A 194
 None
 0.84A 3g8iA-4x4wA:
1.2		 3g8iA-4x4wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x90 GROUP XV
PHOSPHOLIPASE A2

(Homo sapiens) 		PF02450
(LCAT) 		4 LEU A 144
LEU A 376
VAL A 159
LEU A 298
 None
 0.76A 3g8iA-4x90A:
undetectable		 3g8iA-4x90A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 666
VAL A 610
LEU A 624
LEU A 683
 None
 0.92A 3g8iA-4z0cA:
undetectable		 3g8iA-4z0cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 678
GLN A 638
LEU A 621
LEU A 673
 None
 0.93A 3g8iA-4z0cA:
undetectable		 3g8iA-4z0cA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		4 LEU A 290
LEU A  43
LEU A  20
LEU A  76
 None
 0.86A 3g8iA-5dfmA:
undetectable		 3g8iA-5dfmA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 GLN A 810
VAL A 758
LEU A 719
LYS A 779
 None
 0.78A 3g8iA-5gz4A:
undetectable		 3g8iA-5gz4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 168
GLN A  92
LEU A  78
LEU A 268
 None
 0.79A 3g8iA-5hjrA:
undetectable		 3g8iA-5hjrA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho4 HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEINS
A2/B1

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 171
LEU A  47
VAL A  75
LEU A  28
 None
 0.90A 3g8iA-5ho4A:
undetectable		 3g8iA-5ho4A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxd TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 8

(Mus musculus) 		PF05527
(DUF758) 		4 LEU A 132
VAL A 106
LEU A  75
LEU A 182
 None
6OU  A 201 ( 4.9A)
6OU  A 201 ( 4.9A)
None
 0.95A 3g8iA-5jxdA:
undetectable		 3g8iA-5jxdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 LEU A 186
GLN A 202
VAL A 176
LEU A 156
 None
 0.89A 3g8iA-5k6oA:
undetectable		 3g8iA-5k6oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k82 APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE
3G,APOLIPOPROTEIN B
MRNA EDITING ENZYME,
CATALYTIC
PEPTIDE-LIKE 3G

(Macaca mulatta) 		PF08210
(APOBEC_N) 		4 LEU A  71
VAL A  88
LEU A  35
LEU A 193
 None
 0.88A 3g8iA-5k82A:
undetectable		 3g8iA-5k82A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m41 NIGRITOXINE

(Vibrio
nigripulchritudo) 		no annotation 4 GLN A 728
LEU A 742
VAL A 674
LEU A 601
 None
 0.92A 3g8iA-5m41A:
undetectable		 3g8iA-5m41A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		4 LEU A 185
LEU A 237
VAL A 262
LEU A 208
 None
 0.94A 3g8iA-5mwlA:
undetectable		 3g8iA-5mwlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo sapiens) 		no annotation 4 LEU A 259
VAL A 275
LEU A 216
LEU A 377
 None
 0.94A 3g8iA-5sxgA:
undetectable		 3g8iA-5sxgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 LEU C 908
GLN C 603
LEU C 609
LEU C 710
 None
 0.91A 3g8iA-5tw1C:
undetectable		 3g8iA-5tw1C:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 4 GLN D 188
LEU D 172
LEU D 202
LEU B  97
 None
 0.87A 3g8iA-5uz5D:
undetectable		 3g8iA-5uz5D:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2m DNA DC->DU-EDITING
ENZYME APOBEC-3F

(Homo sapiens) 		no annotation 4 LEU A 255
VAL A 271
LEU A 218
LEU A 372
 None
 0.62A 3g8iA-5w2mA:
undetectable		 3g8iA-5w2mA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 GLN A 108
LEU A 229
VAL A 118
LEU A 246
 None
 0.94A 3g8iA-5xnzA:
1.3		 3g8iA-5xnzA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 LEU A 154
VAL A 246
LEU A 237
LEU A 173
 None
 0.73A 3g8iA-6at7A:
undetectable		 3g8iA-6at7A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9x HEPATITIS B VIRUS X
INTERACTING PROTEIN
RAGULATOR COMPLEX
PROTEIN LAMTOR4

(Homo sapiens) 		no annotation 4 LEU E 119
GLN E 159
LEU D  46
VAL E 126
 None
 0.91A 3g8iA-6b9xE:
undetectable		 3g8iA-6b9xE:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 LEU A 143
GLN A 501
LEU A 414
LEU A 561
 None
 0.90A 3g8iA-6cgmA:
undetectable		 3g8iA-6cgmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 4 GLN B 165
LEU B  46
LEU B  30
LEU B  95
 None
 0.72A 3g8iA-6dexB:
undetectable		 3g8iA-6dexB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f7p SERRATE RNA EFFECTOR
MOLECULE HOMOLOG

(Homo sapiens) 		no annotation 4 LEU A 227
VAL A 254
LEU A 268
LEU A 238
 None
 0.76A 3g8iA-6f7pA:
undetectable		 3g8iA-6f7pA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8d SERRATE RNA EFFECTOR
MOLECULE HOMOLOG

(Homo sapiens) 		no annotation 4 LEU A 227
VAL A 254
LEU A 268
LEU A 238
 None
 0.75A 3g8iA-6f8dA:
undetectable		 3g8iA-6f8dA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 LEU A 692
GLN A 657
LEU A 641
LEU A 687
 None
 0.90A 3g8iA-6fnwA:
undetectable		 3g8iA-6fnwA:
17.87