SIMILAR PATTERNS OF AMINO ACIDS FOR 3G7X_B_HSMB176

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		5 TYR A 156
GLU A  39
TYR A 198
ASP A 174
VAL A 173
 ASP  A1234 (-4.5A)
None
None
ASP  A1234 (-2.8A)
None
 1.46A 3g7xB-2v25A:
0.0		 3g7xB-2v25A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 5 ASP B 461
VAL B 460
TYR B 674
ASP B  85
VAL B  84
 None
 1.32A 3g7xB-4iglB:
1.7		 3g7xB-4iglB:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 TYR A 243
VAL A 284
TYR A 270
ASP A 224
VAL A 193
 None
GOL  A 507 (-4.9A)
GOL  A 503 ( 3.9A)
None
None
 1.49A 3g7xB-4yt9A:
0.0		 3g7xB-4yt9A:
18.71