SIMILAR PATTERNS OF AMINO ACIDS FOR 3G6M_A_CFFA427_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2k CHITINASE 1

(Coccidioides
immitis) 		PF00704
(Glyco_hydro_18) 		5 TRP A 131
TYR A 172
MET A 237
ASP A 240
TRP A 245
 None
 0.62A 3g6mA-1d2kA:
62.1		 3g6mA-1d2kA:
51.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 TRP A  97
TYR A 145
MET A 212
ASP A 215
TRP A 220
 NAG  A 503 ( 3.7A)
None
NGO  A 502 (-3.4A)
NGO  A 502 ( 3.1A)
NAG  A 504 (-3.6A)
 0.78A 3g6mA-1e6zA:
5.4		 3g6mA-1e6zA:
31.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hjv CHITINASE-3 LIKE
PROTEIN 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TRP A  99
TYR A 141
MET A 204
ASP A 207
 NAG  A   1 (-3.6A)
NAG  A   1 (-4.9A)
NAG  A   1 (-3.7A)
NAG  A  -1 (-3.7A)
 0.74A 3g6mA-1hjvA:
44.3		 3g6mA-1hjvA:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 TRP A  99
TYR A 141
MET A 210
ASP A 213
TRP A 218
 NAA  A1390 ( 4.3A)
NAA  A1390 (-4.5A)
AMI  A1388 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
 0.84A 3g6mA-1hkkA:
44.6		 3g6mA-1hkkA:
33.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1itx GLYCOSYL HYDROLASE

(Bacillus
circulans) 		PF00704
(Glyco_hydro_18) 		5 TRP A 164
TYR A 205
MET A 277
ASP A 280
TRP A 285
 None
None
GOL  A1007 ( 3.3A)
None
None
 0.66A 3g6mA-1itxA:
49.3		 3g6mA-1itxA:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 TRP A  78
TYR A 120
MET A 189
ASP A 192
 None
 0.62A 3g6mA-1vf8A:
44.7		 3g6mA-1vf8A:
26.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TRP A  99
TYR A 141
MET A 210
ASP A 213
 None
 0.91A 3g6mA-1wb0A:
44.2		 3g6mA-1wb0A:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 TYR A 141
MET A 210
ASP A 213
TRP A 218
 None
 0.55A 3g6mA-1wb0A:
44.2		 3g6mA-1wb0A:
30.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wno CHITINASE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 TRP A  99
TYR A 140
MET A 205
ASP A 208
 None
 0.42A 3g6mA-1wnoA:
24.3		 3g6mA-1wnoA:
56.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 TRP A  99
TYR A 141
MET A 210
ASP A 213
TRP A 218
 CX9  A1399 ( 3.4A)
None
CX9  A1398 (-3.3A)
CX9  A1398 ( 4.4A)
CX9  A1399 (-3.3A)
 0.73A 3g6mA-2ybuA:
44.6		 3g6mA-2ybuA:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3alf CHITINASE, CLASS V

(Nicotiana
tabacum) 		PF00704
(Glyco_hydro_18) 		4 TYR A 116
MET A 181
ASP A 184
TRP A 190
 None
EDO  A 357 ( 3.3A)
EDO  A 359 (-4.5A)
None
 0.61A 3g6mA-3alfA:
41.6		 3g6mA-3alfA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		4 TYR A 117
MET A 182
ASP A 185
TRP A 191
 None
 0.69A 3g6mA-3aquA:
41.4		 3g6mA-3aquA:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 275
MET A 389
ASP A 392
TRP A 397
 None
 1.03A 3g6mA-3b9eA:
40.2		 3g6mA-3b9eA:
26.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g6l CHITINASE

(Clonostachys
rosea) 		PF00704
(Glyco_hydro_18) 		5 TRP A 134
TYR A 175
MET A 240
ASP A 243
TRP A 248
 None
 0.31A 3g6mA-3g6lA:
70.8		 3g6mA-3g6lA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 TRP A 107
TYR A 149
MET A 215
ASP A 218
TRP A 223
 None
 0.67A 3g6mA-3w4rA:
10.2		 3g6mA-3w4rA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 TRP A 107
TYR A 149
MET A 215
ASP A 218
TRP A 223
 NAG  A 505 ( 3.4A)
None
NAG  A 501 (-3.5A)
NAG  A 501 ( 3.2A)
NAG  A 505 (-4.0A)
 0.76A 3g6mA-3wl1A:
10.3		 3g6mA-3wl1A:
27.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dws CHI2

(Yersinia
entomophaga) 		PF00704
(Glyco_hydro_18) 		4 TRP A 308
TYR A 350
MET A 422
ASP A 425
 None
 0.77A 3g6mA-4dwsA:
34.5		 3g6mA-4dwsA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		4 TYR A 120
MET A 189
ASP A 192
TRP A 197
 None
None
None
NAG  A 402 (-3.6A)
 0.55A 3g6mA-4mnmA:
40.8		 3g6mA-4mnmA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		4 TRP A 114
TYR A 154
MET A 220
ASP A 223
 None
None
ACT  A 502 ( 3.1A)
GOL  A 504 (-2.7A)
 0.46A 3g6mA-4q22A:
38.1		 3g6mA-4q22A:
29.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 TYR A 315
MET A 395
ASP A 398
TRP A 403
 None
CS  A 803 (-3.5A)
CS  A 812 (-4.0A)
None
 0.56A 3g6mA-4txgA:
34.4		 3g6mA-4txgA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 5 TRP B 142
TYR B 184
MET B 248
ASP B 251
TRP B 256
 MLI  B 501 ( 3.8A)
None
None
MLI  B 501 ( 4.7A)
MLI  B 501 ( 4.2A)
 0.99A 3g6mA-4w5uB:
44.6		 3g6mA-4w5uB:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5df0 AC-CHIA

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 265
MET A 379
ASP A 382
TRP A 387
 NAG  A 603 ( 3.9A)
58Y  A 605 (-3.3A)
58Y  A 605 ( 3.0A)
NAG  A 603 (-4.5A)
 0.82A 3g6mA-5df0A:
12.6		 3g6mA-5df0A:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 TRP A 268
MET A 381
ASP A 384
TRP A 389
 TRP  A 268 ( 0.5A)
MET  A 381 ( 0.0A)
ASP  A 384 ( 0.5A)
TRP  A 389 (-0.5A)
 0.75A 3g6mA-5gprA:
7.2		 3g6mA-5gprA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TRP B 652
TYR B 692
MET B 764
ASP B 767
TRP B 772
 None
 0.67A 3g6mA-5gztB:
42.2		 3g6mA-5gztB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 TYR B1178
MET B1250
ASP B1253
TRP B1258
 None
 0.56A 3g6mA-5gztB:
42.2		 3g6mA-5gztB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 TRP A 652
TYR A 692
MET A 764
ASP A 767
TRP A 772
 None
 0.60A 3g6mA-5gzuA:
41.6		 3g6mA-5gzuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 TRP A1138
TYR A1178
MET A1250
TRP A1258
 None
 1.05A 3g6mA-5gzuA:
41.6		 3g6mA-5gzuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 TYR A1178
MET A1250
ASP A1253
TRP A1258
 None
 0.59A 3g6mA-5gzuA:
41.6		 3g6mA-5gzuA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvb CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 TRP A 176
TYR A 218
MET A 283
ASP A 286
TRP A 291
 NAG  A 503 (-3.3A)
NAG  A 503 (-4.4A)
NAG  A 503 (-4.0A)
NAG  A 504 (-3.5A)
NAG  A 502 (-4.0A)
 0.77A 3g6mA-5wvbA:
45.5		 3g6mA-5wvbA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 TRP A 606
TYR A 648
MET A 713
ASP A 716
TRP A 721
 NAG  A1004 (-3.4A)
NAG  A1004 (-4.7A)
NAG  A1003 (-3.6A)
NAG  A1003 (-3.1A)
NAG  A1005 (-3.8A)
 0.66A 3g6mA-5wvgA:
43.5		 3g6mA-5wvgA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 TRP A1691
TYR A1734
MET A1801
ASP A1804
TRP A1809
 None
 0.70A 3g6mA-5y29A:
43.3		 3g6mA-5y29A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 TRP A2138
TYR A2181
MET A2248
ASP A2251
TRP A2256
 None
 0.80A 3g6mA-5y2aA:
43.4		 3g6mA-5y2aA:
10.22