SIMILAR PATTERNS OF AMINO ACIDS FOR 3G5D_B_1N1B1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 None
 0.63A 3g5dB-1k2pA:
26.5		 3g5dB-1k2pA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.60A 3g5dB-1k9aA:
33.1		 3g5dB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
VAL A 318
THR A 334
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 ( 4.7A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.78A 3g5dB-1opkA:
32.5		 3g5dB-1opkA:
30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.48A 3g5dB-1py5A:
20.6		 3g5dB-1py5A:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 None
 0.94A 3g5dB-1rjbA:
29.7		 3g5dB-1rjbA:
36.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
VAL A 654
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.82A 3g5dB-1t46A:
31.0		 3g5dB-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
VAL A 352
ALA A 367
GLU A 386
MET A 390
VAL A 399
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.83A 3g5dB-1u59A:
31.7		 3g5dB-1u59A:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
VAL A  68
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.78A 3g5dB-1zltA:
16.4		 3g5dB-1zltA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
THR X  82
TYR X  84
GLY X  88
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.63A 3g5dB-2dq7X:
36.9		 3g5dB-2dq7X:
84.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.60A 3g5dB-2h8hA:
34.1		 3g5dB-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
THR A 338
GLY A 344
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.78A 3g5dB-2hckA:
32.6		 3g5dB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
GLY A 322
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.45A 3g5dB-2hk5A:
29.5		 3g5dB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
MET A 290
VAL A 299
THR A 315
GLY A 321
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.80A 3g5dB-2hz0A:
32.9		 3g5dB-2hz0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.82A 3g5dB-2jkmA:
32.8		 3g5dB-2jkmA:
39.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
TYR A 318
GLY A 322
LEU A 371
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.87A 3g5dB-2og8A:
34.3		 3g5dB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
THR A 316
TYR A 318
ALA A 381
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.3A)
 0.72A 3g5dB-2og8A:
34.3		 3g5dB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 588
VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.85A 3g5dB-2ogvA:
29.2		 3g5dB-2ogvA:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
VAL A 596
ALA A 614
LYS A 616
GLU A 633
MET A 637
TYR A 665
GLY A 669
LEU A 785
 None
 0.94A 3g5dB-2ogvA:
29.2		 3g5dB-2ogvA:
34.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.68A 3g5dB-2psqA:
32.5		 3g5dB-2psqA:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
None
 0.59A 3g5dB-2qluA:
26.4		 3g5dB-2qluA:
26.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 689
ALA A 705
GLU A 724
MET A 728
THR A 753
TYR A 755
GLY A 759
LEU A 807
 None
 0.68A 3g5dB-2r2pA:
34.1		 3g5dB-2r2pA:
42.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  90
ALA A 103
LYS A 105
GLU A 124
VAL A 137
TYR A 155
LEU A 205
ALA A 215
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 (-4.7A)
ANP  A1480 ( 4.9A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.84A 3g5dB-2v55A:
19.4		 3g5dB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.74A 3g5dB-2xikA:
21.0		 3g5dB-2xikA:
29.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
LYS A 653
MET A 674
THR A 699
TYR A 701
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.63A 3g5dB-2xyuA:
28.1		 3g5dB-2xyuA:
42.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		11 LEU A 253
VAL A 261
ALA A 273
LYS A 275
GLU A 290
MET A 294
VAL A 303
THR A 319
GLY A 325
LEU A 374
ALA A 384
 None
 0.66A 3g5dB-2zv7A:
29.0		 3g5dB-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.64A 3g5dB-3b2tA:
25.8		 3g5dB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
None
 0.67A 3g5dB-3b2tA:
25.8		 3g5dB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.83A 3g5dB-3c4fA:
30.5		 3g5dB-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
THR A 266
TYR A 268
GLY A 272
LEU A 321
 None
 0.60A 3g5dB-3d7uA:
28.1		 3g5dB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
None
 0.85A 3g5dB-3hngA:
29.8		 3g5dB-3hngA:
31.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.72A 3g5dB-3hngA:
29.8		 3g5dB-3hngA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
GLY A 135
LEU A 182
ALA A 192
 None
 0.72A 3g5dB-3iecA:
24.1		 3g5dB-3iecA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		8 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
TYR A 131
LEU A 182
ALA A 192
 None
 0.65A 3g5dB-3iecA:
24.1		 3g5dB-3iecA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 696
VAL A 704
LYS A 723
VAL A 753
THR A 768
TYR A 770
GLY A 774
LEU A 822
ALA A 832
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
None
 0.68A 3g5dB-3kexA:
28.4		 3g5dB-3kexA:
33.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
MET A 688
THR A 713
TYR A 715
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-4.1A)
GOL  A 403 (-3.4A)
None
 0.81A 3g5dB-3kulA:
34.3		 3g5dB-3kulA:
38.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		9 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.70A 3g5dB-3mdyA:
26.3		 3g5dB-3mdyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
VAL A  57
ALA A  70
LYS A  72
VAL A 104
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.78A 3g5dB-3mvjA:
22.3		 3g5dB-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
GLY A 283
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.71A 3g5dB-3my0A:
26.5		 3g5dB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
VAL A  96
ALA A 109
LYS A 111
MET A 134
TYR A 161
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
None
None
None
None
 0.80A 3g5dB-3nuuA:
24.3		 3g5dB-3nuuA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
VAL A 247
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.60A 3g5dB-3nyoA:
18.0		 3g5dB-3nyoA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.52A 3g5dB-3ppzA:
30.8		 3g5dB-3ppzA:
32.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 368
GLU A 384
MET A 388
THR A 413
TYR A 415
GLY A 419
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.77A 3g5dB-3s95A:
26.5		 3g5dB-3s95A:
35.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 423
VAL A 431
ALA A 443
MET A 464
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 3g5dB-3sxsA:
32.9		 3g5dB-3sxsA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 431
ALA A 443
LYS A 445
VAL A 473
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.69A 3g5dB-3sxsA:
32.9		 3g5dB-3sxsA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.90A 3g5dB-3tt0A:
30.4		 3g5dB-3tt0A:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.81A 3g5dB-3tt0A:
30.4		 3g5dB-3tt0A:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 139
VAL A 147
ALA A 160
LYS A 162
TYR A 212
GLY A 216
LEU A 263
ALA A 273
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 0.86A 3g5dB-3w18A:
22.5		 3g5dB-3w18A:
24.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
VAL A 899
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.85A 3g5dB-3wzdA:
30.8		 3g5dB-3wzdA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
THR A 697
GLY A 703
LEU A 751
 None
 0.76A 3g5dB-3zfxA:
34.7		 3g5dB-3zfxA:
42.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  83
VAL A  91
ALA A 104
LYS A 106
TYR A 156
GLY A 160
LEU A 207
ALA A 217
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
VX6  A 500 ( 4.2A)
 0.83A 3g5dB-4af3A:
20.1		 3g5dB-4af3A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
THR A 169
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.74A 3g5dB-4aw5A:
28.1		 3g5dB-4aw5A:
42.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 VAL A 222
ALA A 233
GLU A 248
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
None
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.63A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
GLY A 289
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.52A 3g5dB-4c02A:
26.4		 3g5dB-4c02A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
TYR A 703
ALA A 783
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-3.7A)
 0.76A 3g5dB-4ckrA:
29.2		 3g5dB-4ckrA:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
VAL A 721
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.79A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		9 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
TYR A 739
GLY A 743
LEU A 789
ALA A 799
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.76A 3g5dB-4crsA:
17.8		 3g5dB-4crsA:
24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 377
VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
VAL A 433
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.59A 3g5dB-4f4pA:
31.8		 3g5dB-4f4pA:
37.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
VAL A 911
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.70A 3g5dB-4gl9A:
29.3		 3g5dB-4gl9A:
30.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
VAL A 884
TYR A 904
GLY A 908
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.83A 3g5dB-4hviA:
25.7		 3g5dB-4hviA:
33.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 LEU A 273
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.58A 3g5dB-4k11A:
33.8		 3g5dB-4k11A:
94.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 478
VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
GLY A 561
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
None
 0.65A 3g5dB-4k33A:
26.3		 3g5dB-4k33A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
GLY A 105
LEU A 153
ALA A 163
 GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.79A 3g5dB-4lg4A:
18.5		 3g5dB-4lg4A:
28.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLU A  70
MET A  74
VAL A  83
TYR A 101
GLY A 105
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 403 (-4.1A)
GOL  A 404 ( 4.9A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 3.0A)
 0.72A 3g5dB-4lg4A:
18.5		 3g5dB-4lg4A:
28.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		11 LEU A 273
VAL A 281
ALA A 293
LYS A 295
GLU A 310
MET A 314
VAL A 323
TYR A 340
GLY A 344
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.68A 3g5dB-4lggA:
37.8		 3g5dB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
None
 0.66A 3g5dB-4o27B:
20.3		 3g5dB-4o27B:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
VAL A  99
THR A 123
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.70A 3g5dB-4o38A:
21.3		 3g5dB-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.82A 3g5dB-4o38A:
21.3		 3g5dB-4o38A:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
VAL A 394
ALA A 407
LYS A 409
GLU A 428
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.58A 3g5dB-4q9zA:
16.7		 3g5dB-4q9zA:
24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.74A 3g5dB-4rt7A:
24.7		 3g5dB-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		11 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.65A 3g5dB-4ueuA:
35.5		 3g5dB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		11 LEU A  14
VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
THR A  81
TYR A  83
GLY A  87
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.56A 3g5dB-4ueuA:
35.5		 3g5dB-4ueuA:
62.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
VAL A 112
ALA A 125
LYS A 127
VAL A 159
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.76A 3g5dB-4wb7A:
22.3		 3g5dB-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
VAL A 248
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.79A 3g5dB-4wboA:
23.7		 3g5dB-4wboA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 10 LEU B 267
VAL B 275
ALA B 288
LYS B 290
MET B 309
VAL B 318
THR B 334
GLY B 340
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 ( 4.3A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.51A 3g5dB-4xeyB:
27.4		 3g5dB-4xeyB:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
VAL A 416
ALA A 428
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 None
 0.71A 3g5dB-4xi2A:
24.4		 3g5dB-4xi2A:
28.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.68A 3g5dB-4xufA:
24.3		 3g5dB-4xufA:
38.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
MET A 665
VAL A 675
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.79A 3g5dB-4xufA:
24.3		 3g5dB-4xufA:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		9 LEU A 408
VAL A 416
ALA A 428
LYS A 430
VAL A 458
THR A 474
TYR A 476
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.65A 3g5dB-4y93A:
31.2		 3g5dB-4y93A:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.73A 3g5dB-5a46A:
30.8		 3g5dB-5a46A:
32.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.72A 3g5dB-5f1zA:
29.4		 3g5dB-5f1zA:
33.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 730
VAL A 738
ALA A 756
LYS A 758
GLU A 775
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.63A 3g5dB-5fm2A:
33.1		 3g5dB-5fm2A:
31.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
VAL A 658
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.78A 3g5dB-5grnA:
25.3		 3g5dB-5grnA:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
VAL A  74
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.83A 3g5dB-5hu3A:
24.9		 3g5dB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
VAL A  74
GLY A  96
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.80A 3g5dB-5hu3A:
24.9		 3g5dB-5hu3A:
26.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
MET A  99
VAL A 109
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.70A 3g5dB-5i3oA:
23.5		 3g5dB-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
MET A  99
VAL A 109
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.68A 3g5dB-5i3oA:
23.5		 3g5dB-5i3oA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
GLY A  96
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.73A 3g5dB-5j5tA:
22.8		 3g5dB-5j5tA:
23.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 718
VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.57A 3g5dB-5j9zA:
32.7		 3g5dB-5j9zA:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 284
ALA A 297
LYS A 299
MET A 319
VAL A 328
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.60A 3g5dB-5kbrA:
24.3		 3g5dB-5kbrA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
VAL A 157
GLY A 181
LEU A 232
ALA A 540
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 ( 4.5A)
 1.10A 3g5dB-5myvA:
21.4		 3g5dB-5myvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 144
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.88A 3g5dB-5u7qA:
20.2		 3g5dB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A 106
ALA A 119
LYS A 121
GLU A 140
VAL A 153
TYR A 171
GLY A 175
LEU A 221
ALA A 231
 None
 0.73A 3g5dB-5u7qA:
20.2		 3g5dB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.76A 3g5dB-5w5jA:
19.5		 3g5dB-5w5jA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 8 LEU A 891
VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.80A 3g5dB-5wnoA:
28.3		 3g5dB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 8 VAL A  83
ALA A  95
LYS A  97
VAL A 125
TYR A 143
GLY A 147
LEU A 206
ALA A 216
 ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
MG  A1001 ( 4.4A)
 0.71A 3g5dB-5xd6A:
22.7		 3g5dB-5xd6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 LEU A  33
VAL A  41
ALA A  54
VAL A  83
TYR A 101
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.63A 3g5dB-6ao5A:
23.2		 3g5dB-6ao5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 VAL A  41
ALA A  54
LYS A  56
VAL A  83
TYR A 101
GLY A 105
LEU A 153
ALA A 163
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
None
 0.79A 3g5dB-6ao5A:
23.2		 3g5dB-6ao5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 8 VAL A 741
ALA A 754
LYS A 756
GLU A 774
VAL A 787
TYR A 815
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.85A 3g5dB-6b3eA:
24.5		 3g5dB-6b3eA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 8 LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
VAL A 938
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.62A 3g5dB-6c7yA:
29.8		 3g5dB-6c7yA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
ALA A  87
LYS A  89
MET A 111
VAL A 120
TYR A 138
LEU A 189
ALA A 199
 None
 0.75A 3g5dB-6c9dA:
23.0		 3g5dB-6c9dA:
14.03