SIMILAR PATTERNS OF AMINO ACIDS FOR 3G4L_D_ROFD904_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 3 ASN P 334
MET P 262
PHE P 276
 None
 1.06A 3g4lD-1cf2P:
undetectable		 3g4lD-1cf2P:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 ASN A 279
MET A 271
PHE A 288
 SAM  A1699 (-4.0A)
None
None
 0.98A 3g4lD-1fpqA:
undetectable		 3g4lD-1fpqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ASN D 605
MET D 696
PHE D 702
 None
 1.09A 3g4lD-1hqrD:
undetectable		 3g4lD-1hqrD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlx AGGLUTININ

(Amaranthus
caudatus) 		PF07468
(Agglutinin) 		3 ASN A 123
MET A   7
PHE A 149
 None
 1.00A 3g4lD-1jlxA:
undetectable		 3g4lD-1jlxA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 112
MET A 242
PHE A 136
 None
 0.85A 3g4lD-1kblA:
undetectable		 3g4lD-1kblA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 ASN A 122
MET A 145
PHE A 161
 None
 1.02A 3g4lD-1khdA:
undetectable		 3g4lD-1khdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASN A 173
MET A 194
PHE A 183
 None
 1.08A 3g4lD-1n21A:
1.2		 3g4lD-1n21A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 ASN A  13
MET A 118
PHE A  49
 None
 1.02A 3g4lD-1nxuA:
0.0		 3g4lD-1nxuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 ASN A  53
MET A  29
PHE A  23
 None
 1.12A 3g4lD-1qfcA:
0.6		 3g4lD-1qfcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 ASN A  67
MET A  32
PHE A  74
 None
 0.95A 3g4lD-1qgjA:
0.3		 3g4lD-1qgjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnz 0.5B ANTIBODY (HEAVY
CHAIN)
0.5B ANTIBODY (LIGHT
CHAIN)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 ASN L  96
MET H 218
PHE L 100
 None
 0.91A 3g4lD-1qnzL:
undetectable		 3g4lD-1qnzL:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qok MFE-23 RECOMBINANT
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 ASN A 123
MET A 193
PHE A 258
 None
 1.13A 3g4lD-1qokA:
undetectable		 3g4lD-1qokA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		3 ASN A  75
MET A 113
PHE A  80
 None
 1.09A 3g4lD-1r5jA:
undetectable		 3g4lD-1r5jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA
FAB 17-IA

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 ASN H  35
MET L  33
PHE L  98
 None
 1.08A 3g4lD-1rvfH:
undetectable		 3g4lD-1rvfH:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		3 ASN A  70
MET A  32
PHE A  77
 None
 0.98A 3g4lD-1schA:
undetectable		 3g4lD-1schA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN

(Drosophila
melanogaster) 		PF09247
(TBP-binding) 		3 ASN A  55
MET A  67
PHE A  25
 None
 1.09A 3g4lD-1tbaA:
undetectable		 3g4lD-1tbaA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 229
MET A 178
PHE A 193
 None
 1.08A 3g4lD-1u6rA:
undetectable		 3g4lD-1u6rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		3 ASN A 374
MET A 312
PHE A 331
 None
 1.12A 3g4lD-1uz4A:
undetectable		 3g4lD-1uz4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 117
MET A 245
PHE A 140
 None
 1.07A 3g4lD-1vbgA:
undetectable		 3g4lD-1vbgA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASN A 119
MET A  80
PHE A 141
 None
 0.83A 3g4lD-1zpuA:
undetectable		 3g4lD-1zpuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		3 ASN X 156
MET X 123
PHE X 233
 None
 1.05A 3g4lD-2ae0X:
undetectable		 3g4lD-2ae0X:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A 501
MET A 631
PHE A 508
 None
 1.13A 3g4lD-2d3tA:
undetectable		 3g4lD-2d3tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 223
MET A 173
PHE A 188
 None
 1.11A 3g4lD-2j1qA:
undetectable		 3g4lD-2j1qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1

(Gallus gallus) 		PF01267
(F-actin_cap_A) 		3 ASN A  30
MET A  59
PHE A  54
 None
 0.95A 3g4lD-2kxpA:
undetectable		 3g4lD-2kxpA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 533
MET A 569
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.69A 3g4lD-2qykA:
53.9		 3g4lD-2qykA:
85.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ASN A  90
MET A  10
PHE A  65
 None
 0.52A 3g4lD-2rfqA:
undetectable		 3g4lD-2rfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens) 		PF11563
(Protoglobin) 		3 ASN A  31
MET A 107
PHE A  70
 None
HEM  A 200 (-3.9A)
None
 1.11A 3g4lD-2w31A:
undetectable		 3g4lD-2w31A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 ASN A 314
MET A 301
PHE A 340
 None
 0.99A 3g4lD-2wu0A:
undetectable		 3g4lD-2wu0A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 116
MET A 246
PHE A 141
 None
 1.08A 3g4lD-2x0sA:
undetectable		 3g4lD-2x0sA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		3 ASN B  32
MET A 369
PHE B  39
 None
HAS  A1016 ( 4.8A)
None
 0.86A 3g4lD-2yevB:
undetectable		 3g4lD-2yevB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		3 ASN A 251
MET A 672
PHE A 319
 None
 1.13A 3g4lD-2yfsA:
undetectable		 3g4lD-2yfsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		3 ASN A 164
MET A 173
PHE A 168
 None
 1.04A 3g4lD-2yg6A:
undetectable		 3g4lD-2yg6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znm THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		3 ASN A  88
MET A  68
PHE A  30
 None
 1.08A 3g4lD-2znmA:
undetectable		 3g4lD-2znmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 ASN A 413
MET A 370
PHE A 400
 None
 0.70A 3g4lD-3aflA:
undetectable		 3g4lD-3aflA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		3 ASN A 169
MET A 150
PHE A 145
 None
 1.15A 3g4lD-3c0uA:
undetectable		 3g4lD-3c0uA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 ASN B 386
MET B 368
PHE B 442
 None
 0.84A 3g4lD-3dw8B:
undetectable		 3g4lD-3dw8B:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 487
MET A 523
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.67A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		3 ASN A  47
MET A 124
PHE A 118
 None
 1.09A 3g4lD-3gd9A:
undetectable		 3g4lD-3gd9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 811
MET B 767
PHE B 840
 None
 0.99A 3g4lD-3h0gB:
undetectable		 3g4lD-3h0gB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		3 ASN A 309
MET A 333
PHE A 287
 None
 0.74A 3g4lD-3hk0A:
undetectable		 3g4lD-3hk0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8v H16.14J HEAVY CHAIN
H16.14J LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 ASN L  42
MET H 100
PHE H  91
 None
 1.02A 3g4lD-3j8vL:
undetectable		 3g4lD-3j8vL:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		3 ASN P 145
MET P   1
PHE P 117
 None
 0.97A 3g4lD-3j9tP:
undetectable		 3g4lD-3j9tP:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ASN X  60
MET X  70
PHE X  27
 None
 1.08A 3g4lD-3jb9X:
undetectable		 3g4lD-3jb9X:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG

(Homo sapiens) 		PF09174
(Maf1) 		3 ASN A 140
MET A   1
PHE A 142
 None
 0.99A 3g4lD-3nr5A:
undetectable		 3g4lD-3nr5A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		3 ASN A 146
MET A 166
PHE A 150
 None
 0.80A 3g4lD-3nwnA:
undetectable		 3g4lD-3nwnA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 395
MET A 431
PHE A 446
 ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.6A)
 0.68A 3g4lD-3o57A:
52.2		 3g4lD-3o57A:
80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		3 ASN A 187
MET A 213
PHE A 191
 None
 0.86A 3g4lD-3odnA:
undetectable		 3g4lD-3odnA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4;
Human
gammaherpesvirus
4) 		no annotation
no annotation 		3 ASN B 127
MET A  68
PHE B  59
 None
 1.08A 3g4lD-3phfB:
undetectable		 3g4lD-3phfB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4h PE FAMILY PROTEIN
LOW MOLECULAR WEIGHT
PROTEIN ANTIGEN 7

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		no annotation
PF06013
(WXG100) 		3 ASN B   7
MET B  18
PHE A  42
 None
 0.83A 3g4lD-3q4hB:
undetectable		 3g4lD-3q4hB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASN A 474
MET A 525
PHE A 472
 None
 0.86A 3g4lD-3r6kA:
undetectable		 3g4lD-3r6kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		3 ASN A 209
MET A 225
PHE A 202
 None
 1.07A 3g4lD-3rotA:
undetectable		 3g4lD-3rotA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 ASN A 343
MET A   6
PHE A  53
 None
 1.11A 3g4lD-3tktA:
undetectable		 3g4lD-3tktA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 3 ASN B 128
MET B 260
PHE B 213
 None
 0.88A 3g4lD-3uajB:
undetectable		 3g4lD-3uajB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 ASN A 270
MET A 288
PHE A 336
 None
 0.81A 3g4lD-3vm7A:
undetectable		 3g4lD-3vm7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 ASN A 218
MET A 155
PHE A 195
 None
 1.02A 3g4lD-3vv3A:
undetectable		 3g4lD-3vv3A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 ASN A 630
MET A 593
PHE A 639
 None
 1.06A 3g4lD-3zukA:
undetectable		 3g4lD-3zukA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ASN A 748
MET A1170
PHE A1068
 None
 1.09A 3g4lD-4c3hA:
undetectable		 3g4lD-4c3hA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c53 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Guanarito
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 ASN A 307
MET A 400
PHE A 302
 NAG  A1407 ( 4.6A)
None
None
 1.10A 3g4lD-4c53A:
undetectable		 3g4lD-4c53A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 3 ASN A 228
MET A 235
PHE A 199
 None
 1.07A 3g4lD-4d0kA:
undetectable		 3g4lD-4d0kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		3 ASN A 327
MET A 142
PHE A  65
 None
 1.15A 3g4lD-4f0lA:
undetectable		 3g4lD-4f0lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ASN B 773
MET B 178
PHE B 737
 None
 1.10A 3g4lD-4gnkB:
undetectable		 3g4lD-4gnkB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		3 ASN A 263
MET A 273
PHE A 340
 None
 1.14A 3g4lD-4h3wA:
undetectable		 3g4lD-4h3wA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		3 ASN A  23
MET A 211
PHE A 237
 None
 1.15A 3g4lD-4lgcA:
undetectable		 3g4lD-4lgcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 ASN A 335
MET A 508
PHE A 318
 ONL  A 601 (-3.5A)
None
None
 1.14A 3g4lD-4o7dA:
undetectable		 3g4lD-4o7dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		3 ASN A 453
MET A 484
PHE A 176
 None
 0.87A 3g4lD-4r1iA:
undetectable		 3g4lD-4r1iA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 567
MET A 603
PHE A 618
 None
 0.89A 3g4lD-4wziA:
52.2		 3g4lD-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 3 ASN C 757
MET C 714
PHE C 754
 None
 0.83A 3g4lD-4wzsC:
undetectable		 3g4lD-4wzsC:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		3 ASN A 318
MET A 307
PHE A 323
 None
 1.09A 3g4lD-5a08A:
undetectable		 3g4lD-5a08A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ASN A1725
MET A1761
PHE A1745
 None
 1.15A 3g4lD-5a22A:
undetectable		 3g4lD-5a22A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 ASN A1532
MET A1024
PHE A1566
 None
 0.71A 3g4lD-5a31A:
undetectable		 3g4lD-5a31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		3 ASN M 273
MET M 297
PHE M 311
 None
 0.82A 3g4lD-5a5tM:
undetectable		 3g4lD-5a5tM:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASN A 397
MET A 520
PHE A 376
 TPP  A 700 (-4.0A)
None
None
 1.01A 3g4lD-5ahkA:
undetectable		 3g4lD-5ahkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		3 ASN A  81
MET A  98
PHE A  78
 None
 1.00A 3g4lD-5bzaA:
undetectable		 3g4lD-5bzaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		3 ASN A 172
MET A 191
PHE A 230
 None
 0.80A 3g4lD-5dkvA:
undetectable		 3g4lD-5dkvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 ASN B 374
MET B 288
PHE B 365
 None
 1.02A 3g4lD-5exrB:
undetectable		 3g4lD-5exrB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo TRANSFORMING GROWTH
FACTOR BETA-1

(Homo sapiens) 		PF00019
(TGF_beta)
PF00688
(TGFb_propeptide) 		3 ASN C 155
MET C 104
PHE C 169
 None
 1.04A 3g4lD-5ffoC:
undetectable		 3g4lD-5ffoC:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H 159
MET L  37
PHE L 102
 None
 1.12A 3g4lD-5fhxH:
undetectable		 3g4lD-5fhxH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP120 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 ASN G  94
MET G 271
PHE G 233
 None
 1.03A 3g4lD-5fyjG:
undetectable		 3g4lD-5fyjG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghu PROBABLE FIMBRIAL
CHAPERONE YADV

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		3 ASN A 219
MET A 190
PHE A 206
 None
 1.07A 3g4lD-5ghuA:
undetectable		 3g4lD-5ghuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 ASN A 104
MET A 132
PHE A 100
 None
 1.01A 3g4lD-5i0pA:
undetectable		 3g4lD-5i0pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 822
MET B 778
PHE B 851
 None
 1.09A 3g4lD-5ip9B:
undetectable		 3g4lD-5ip9B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASN A 110
MET A 100
PHE A  84
 None
 1.15A 3g4lD-5khaA:
undetectable		 3g4lD-5khaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF03279
(Lip_A_acyltrans) 		3 ASN B  74
MET B 129
PHE B 123
 None
 1.10A 3g4lD-5kn7B:
undetectable		 3g4lD-5kn7B:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 ASN A1532
MET A1024
PHE A1566
 None
 0.65A 3g4lD-5lcwA:
undetectable		 3g4lD-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 115
MET A 243
PHE A 138
 None
ADP  A 901 (-3.5A)
None
 0.76A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 826
MET A 707
PHE A 766
 None
 1.14A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		3 ASN A 276
MET A 349
PHE A 243
 None
 0.86A 3g4lD-5myuA:
undetectable		 3g4lD-5myuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 3 ASN A 513
MET A 454
PHE A 497
 None
 1.16A 3g4lD-5ny0A:
undetectable		 3g4lD-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 3 ASN A 567
MET A 603
PHE A 618
 9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
 0.86A 3g4lD-5ohjA:
53.5		 3g4lD-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ASN Y 707
MET Y 537
PHE Y 529
 None
 1.11A 3g4lD-5svaY:
undetectable		 3g4lD-5svaY:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		3 ASN A  68
MET A  32
PHE A  75
 None
None
SO4  A 304 (-4.5A)
 0.91A 3g4lD-5twtA:
undetectable		 3g4lD-5twtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 223
MET A 173
PHE A 188
 None
 1.13A 3g4lD-5u8eA:
undetectable		 3g4lD-5u8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF14629
(ORC4_C) 		3 ASN D 409
MET D 496
PHE D 499
 None
 1.14A 3g4lD-5udbD:
undetectable		 3g4lD-5udbD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2
CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF16679
(CDT1_C) 		3 ASN 8 157
MET 2 783
PHE 2 828
 None
 1.10A 3g4lD-5udb8:
undetectable		 3g4lD-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmn BAK PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 ASN A   3
MET A  26
PHE A   6
 NO3  A 206 (-4.8A)
None
NO3  A 206 ( 4.6A)
 0.81A 3g4lD-5vmnA:
undetectable		 3g4lD-5vmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 3 ASN A  99
MET A 172
PHE A  94
 None
 0.99A 3g4lD-5weaA:
undetectable		 3g4lD-5weaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 822
MET B 778
PHE B 851
 None
 1.10A 3g4lD-5xogB:
undetectable		 3g4lD-5xogB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASN B  76
MET B  69
PHE B  34
 None
 1.04A 3g4lD-6b0eB:
undetectable		 3g4lD-6b0eB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 3 ASN A 227
MET A 222
PHE A 196
 None
 1.07A 3g4lD-6b4oA:
undetectable		 3g4lD-6b4oA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN D 339
MET D 278
PHE D 332
 None
 0.84A 3g4lD-6eojD:
undetectable		 3g4lD-6eojD:
21.10