SIMILAR PATTERNS OF AMINO ACIDS FOR 3G4L_D_ROFD904

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		5 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.47A 3g4lD-1fiuA:
undetectable		 3g4lD-1fiuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 PRO A 347
THR A 213
ILE A 210
MET A 209
SER A 374
 None
 1.42A 3g4lD-1geuA:
undetectable		 3g4lD-1geuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		5 ASP A 107
TRP A 130
THR A 137
ILE A 136
SER A  95
 None
 1.46A 3g4lD-1j5wA:
undetectable		 3g4lD-1j5wA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
GLN A 988
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
 0.51A 3g4lD-1sojA:
41.3		 3g4lD-1sojA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 MET D  61
LEU D  58
PRO D 132
ILE D  92
MET D  88
 None
 1.37A 3g4lD-1sxjD:
undetectable		 3g4lD-1sxjD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um1 KIAA1849 PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
 None
 1.46A 3g4lD-1um1A:
undetectable		 3g4lD-1um1A:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ups GLCNAC-ALPHA-1,4-GAL
-RELEASING
ENDO-BETA-GALACTOSID
ASE

(Clostridium
perfringens) 		PF00722
(Glyco_hydro_16) 		5 PRO A  54
TRP A  56
ILE A 106
MET A 153
SER A 100
 None
 1.46A 3g4lD-1upsA:
undetectable		 3g4lD-1upsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 LEU A 256
PRO A 195
TRP A 209
THR A 208
ILE A 210
 None
 1.43A 3g4lD-1urtA:
undetectable		 3g4lD-1urtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 ASP A 255
LEU A 251
THR A 214
SER A 245
GLN A 217
 None
 1.49A 3g4lD-1vp5A:
undetectable		 3g4lD-1vp5A:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
GLN A 413
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.0A)
 0.36A 3g4lD-1zklA:
45.1		 3g4lD-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1znp HYPOTHETICAL PROTEIN
ATU3615

(Agrobacterium
fabrum) 		PF06172
(Cupin_5) 		5 TYR A  25
HIS A  19
THR A  28
ILE A  43
SER A  40
 None
 1.32A 3g4lD-1znpA:
undetectable		 3g4lD-1znpA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		5 HIS A 239
ASP A 324
LEU A  60
ILE A 183
SER A 147
 CO  A1000 (-3.4A)
None
None
None
None
 1.21A 3g4lD-2amxA:
undetectable		 3g4lD-2amxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyu TWITCHING MOTILITY
PROTEIN PILT

(Aquifex
aeolicus) 		PF00437
(T2SSE) 		5 MET A 218
LEU A 140
THR A 152
ILE A 153
SER A 147
 None
 1.46A 3g4lD-2eyuA:
undetectable		 3g4lD-2eyuA:
23.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TRP A 544
THR A 545
ILE A 548
MET A 549
SER A 580
GLN A 581
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
 0.33A 3g4lD-2qykA:
53.9		 3g4lD-2qykA:
85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 371
HIS A 376
MET A 485
LEU A 531
THR A 545
SER A 580
GLN A 581
 NPV  A   3 (-4.4A)
ZN  A   1 (-3.3A)
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
 1.49A 3g4lD-2qykA:
53.9		 3g4lD-2qykA:
85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TRP A 454
THR A 455
ILE A 458
 None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
 0.49A 3g4lD-2qymA:
44.9		 3g4lD-2qymA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 281
PRO A 444
TRP A 454
THR A 455
ILE A 458
MET A 459
 None
 0.97A 3g4lD-2qymA:
44.9		 3g4lD-2qymA:
83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.30A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
GLN A 887
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.3A)
 0.45A 3g4lD-2r8qA:
39.2		 3g4lD-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 MET A 245
ASP A 358
LEU A 184
ILE A  33
MET A  38
 None
 1.48A 3g4lD-2rfqA:
undetectable		 3g4lD-2rfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 MET A 306
LEU A 727
THR A 637
ILE A 358
GLN A 348
 None
 1.21A 3g4lD-2x05A:
undetectable		 3g4lD-2x05A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
 1.02A 3g4lD-3b2rA:
31.9		 3g4lD-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
 0.55A 3g4lD-3b2rA:
31.9		 3g4lD-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
 0.90A 3g4lD-3bjcA:
34.7		 3g4lD-3bjcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
 0.53A 3g4lD-3bjcA:
34.7		 3g4lD-3bjcA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
GLN A 778
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
 0.41A 3g4lD-3ecnA:
44.7		 3g4lD-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		6 HIS A 326
MET A 439
ASP A 484
LEU A 485
MET A 503
SER A 534
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
 0.91A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
GLN A 535
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
 0.57A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
 None
None
ZN  A   1 (-2.7A)
None
None
None
 0.93A 3g4lD-3ibjA:
32.8		 3g4lD-3ibjA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
TRP A 416
GLN A 453
 None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.5A)
 0.62A 3g4lD-3n3zA:
40.9		 3g4lD-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TRP A 406
THR A 407
ILE A 410
MET A 411
SER A 442
GLN A 443
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
None
ZG2  A 506 (-3.3A)
 0.37A 3g4lD-3o57A:
52.2		 3g4lD-3o57A:
80.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
 0.33A 3g4lD-3sl5A:
52.9		 3g4lD-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
GLN A 726
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
 0.75A 3g4lD-3ui7A:
38.3		 3g4lD-3ui7A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		7 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
GLN A 570
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.3A)
 0.73A 3g4lD-3v94A:
39.8		 3g4lD-3v94A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dh2 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION

(Ruminiclostridium
thermocellum) 		PF00963
(Cohesin) 		5 HIS A  44
ASP A 145
LEU A 146
ILE A 149
SER A 139
 None
 1.36A 3g4lD-4dh2A:
undetectable		 3g4lD-4dh2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		5 ASP A 400
THR A 363
ILE A 395
MET A 393
GLN A 382
 None
 1.29A 3g4lD-4eppA:
undetectable		 3g4lD-4eppA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
 None
None
ZN  A1001 (-2.5A)
None
None
None
 0.60A 3g4lD-4htzA:
38.8		 3g4lD-4htzA:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.40A 3g4lD-4i15A:
38.5		 3g4lD-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
MET A 785
ASP A 822
TRP A 836
GLN A 874
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.50A 3g4lD-4i15A:
38.5		 3g4lD-4i15A:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 LEU B 179
THR B 183
ILE B 182
SER B  80
GLN B  79
 None
None
None
GCP  B 701 (-4.5A)
GCP  B 701 (-3.8A)
 1.42A 3g4lD-4p4sB:
undetectable		 3g4lD-4p4sB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v23 MATRIX PROTEIN

(Respiratory
syncytial virus) 		PF03393
(Pneumo_matrix) 		5 MET A  84
LEU A  52
THR A  33
ILE A  34
SER A 198
 None
 1.07A 3g4lD-4v23A:
undetectable		 3g4lD-4v23A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmd ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF05409
(Peptidase_C30) 		5 TYR A  54
MET A  25
LEU A  49
THR A  88
GLN A 167
 None
None
PGE  A 402 ( 4.8A)
None
None
 1.50A 3g4lD-4wmdA:
undetectable		 3g4lD-4wmdA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.61A 3g4lD-4wziA:
52.2		 3g4lD-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az0 UNCHARACTERIZED
PROTEIN

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		5 ASP A 299
LEU A 295
THR A 258
SER A 289
GLN A 261
 None
 1.46A 3g4lD-5az0A:
undetectable		 3g4lD-5az0A:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		9 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
GLN A 421
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
 0.58A 3g4lD-5b25A:
43.5		 3g4lD-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
MET A 785
ASP A 823
TRP A 837
GLN A 875
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.0A)
 0.45A 3g4lD-5h2rA:
39.2		 3g4lD-5h2rA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 12 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
 None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
 0.23A 3g4lD-5ohjA:
53.5		 3g4lD-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5op0 DNA POLYMERASE LIGD,
POLYMERASE DOMAIN

(Mycolicibacterium
smegmatis) 		no annotation 5 TYR B  74
ASP B 238
PRO B 123
THR B 120
SER B 176
 None
 1.23A 3g4lD-5op0B:
undetectable		 3g4lD-5op0B:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
 None
None
ZN  A 401 (-2.4A)
None
None
 0.45A 3g4lD-5vydA:
39.5		 3g4lD-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
 None
None
ZN  A 401 (-2.4A)
None
None
 0.43A 3g4lD-5vydA:
39.5		 3g4lD-5vydA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 11 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
GLN A 369
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.0A)
 0.26A 3g4lD-5wh6A:
54.0		 3g4lD-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 11 TYR A 159
HIS A 160
MET A 273
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-2.5A)
AKJ  A 601 (-3.0A)
 0.50A 3g4lD-5wh6A:
54.0		 3g4lD-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9x SMALL RNA DEGRADING
NUCLEASE 1

(Arabidopsis
thaliana) 		no annotation 5 HIS A 236
LEU A  85
THR A 138
ILE A 219
MET A 140
 None
 1.33A 3g4lD-5z9xA:
undetectable		 3g4lD-5z9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 3 ASN P 334
MET P 262
PHE P 276
 None
 1.06A 3g4lD-1cf2P:
undetectable		 3g4lD-1cf2P:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		3 ASN A 279
MET A 271
PHE A 288
 SAM  A1699 (-4.0A)
None
None
 0.98A 3g4lD-1fpqA:
undetectable		 3g4lD-1fpqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C

(Streptococcus
pyogenes) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		3 ASN D 605
MET D 696
PHE D 702
 None
 1.09A 3g4lD-1hqrD:
undetectable		 3g4lD-1hqrD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlx AGGLUTININ

(Amaranthus
caudatus) 		PF07468
(Agglutinin) 		3 ASN A 123
MET A   7
PHE A 149
 None
 1.00A 3g4lD-1jlxA:
undetectable		 3g4lD-1jlxA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbl PYRUVATE PHOSPHATE
DIKINASE

([Clostridium]
symbiosum) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 112
MET A 242
PHE A 136
 None
 0.85A 3g4lD-1kblA:
undetectable		 3g4lD-1kblA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 ASN A 122
MET A 145
PHE A 161
 None
 1.02A 3g4lD-1khdA:
undetectable		 3g4lD-1khdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n21 (+)-BORNYL
DIPHOSPHATE SYNTHASE

(Salvia
officinalis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ASN A 173
MET A 194
PHE A 183
 None
 1.08A 3g4lD-1n21A:
1.2		 3g4lD-1n21A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 ASN A  13
MET A 118
PHE A  49
 None
 1.02A 3g4lD-1nxuA:
0.0		 3g4lD-1nxuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfc PROTEIN (PURPLE ACID
PHOSPHATASE)

(Rattus
norvegicus) 		PF00149
(Metallophos) 		3 ASN A  53
MET A  29
PHE A  23
 None
 1.12A 3g4lD-1qfcA:
0.6		 3g4lD-1qfcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		3 ASN A  67
MET A  32
PHE A  74
 None
 0.95A 3g4lD-1qgjA:
0.3		 3g4lD-1qgjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnz 0.5B ANTIBODY (HEAVY
CHAIN)
0.5B ANTIBODY (LIGHT
CHAIN)

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 ASN L  96
MET H 218
PHE L 100
 None
 0.91A 3g4lD-1qnzL:
undetectable		 3g4lD-1qnzL:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qok MFE-23 RECOMBINANT
ANTIBODY FRAGMENT

(Mus musculus) 		PF07686
(V-set) 		3 ASN A 123
MET A 193
PHE A 258
 None
 1.13A 3g4lD-1qokA:
undetectable		 3g4lD-1qokA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E

(Streptococcus
pyogenes) 		PF01515
(PTA_PTB) 		3 ASN A  75
MET A 113
PHE A  80
 None
 1.09A 3g4lD-1r5jA:
undetectable		 3g4lD-1r5jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvf FAB 17-IA
FAB 17-IA

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 ASN H  35
MET L  33
PHE L  98
 None
 1.08A 3g4lD-1rvfH:
undetectable		 3g4lD-1rvfH:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sch PEANUT PEROXIDASE,
MAJOR CATIONIC
ISOZYME

(Arachis
hypogaea) 		PF00141
(peroxidase) 		3 ASN A  70
MET A  32
PHE A  77
 None
 0.98A 3g4lD-1schA:
undetectable		 3g4lD-1schA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN

(Drosophila
melanogaster) 		PF09247
(TBP-binding) 		3 ASN A  55
MET A  67
PHE A  25
 None
 1.09A 3g4lD-1tbaA:
undetectable		 3g4lD-1tbaA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 229
MET A 178
PHE A 193
 None
 1.08A 3g4lD-1u6rA:
undetectable		 3g4lD-1u6rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		3 ASN A 374
MET A 312
PHE A 331
 None
 1.12A 3g4lD-1uz4A:
undetectable		 3g4lD-1uz4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 117
MET A 245
PHE A 140
 None
 1.07A 3g4lD-1vbgA:
undetectable		 3g4lD-1vbgA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASN A 119
MET A  80
PHE A 141
 None
 0.83A 3g4lD-1zpuA:
undetectable		 3g4lD-1zpuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		3 ASN X 156
MET X 123
PHE X 233
 None
 1.05A 3g4lD-2ae0X:
undetectable		 3g4lD-2ae0X:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 ASN A 501
MET A 631
PHE A 508
 None
 1.13A 3g4lD-2d3tA:
undetectable		 3g4lD-2d3tA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 223
MET A 173
PHE A 188
 None
 1.11A 3g4lD-2j1qA:
undetectable		 3g4lD-2j1qA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1

(Gallus gallus) 		PF01267
(F-actin_cap_A) 		3 ASN A  30
MET A  59
PHE A  54
 None
 0.95A 3g4lD-2kxpA:
undetectable		 3g4lD-2kxpA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 533
MET A 569
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.69A 3g4lD-2qykA:
53.9		 3g4lD-2qykA:
85.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 ASN A  90
MET A  10
PHE A  65
 None
 0.52A 3g4lD-2rfqA:
undetectable		 3g4lD-2rfqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w31 GLOBIN

(Geobacter
sulfurreducens) 		PF11563
(Protoglobin) 		3 ASN A  31
MET A 107
PHE A  70
 None
HEM  A 200 (-3.9A)
None
 1.11A 3g4lD-2w31A:
undetectable		 3g4lD-2w31A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		3 ASN A 314
MET A 301
PHE A 340
 None
 0.99A 3g4lD-2wu0A:
undetectable		 3g4lD-2wu0A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0s PYRUVATE PHOSPHATE
DIKINASE

(Trypanosoma
brucei) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 116
MET A 246
PHE A 141
 None
 1.08A 3g4lD-2x0sA:
undetectable		 3g4lD-2x0sA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III
CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3)
PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		3 ASN B  32
MET A 369
PHE B  39
 None
HAS  A1016 ( 4.8A)
None
 0.86A 3g4lD-2yevB:
undetectable		 3g4lD-2yevB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		3 ASN A 251
MET A 672
PHE A 319
 None
 1.13A 3g4lD-2yfsA:
undetectable		 3g4lD-2yfsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		3 ASN A 164
MET A 173
PHE A 168
 None
 1.04A 3g4lD-2yg6A:
undetectable		 3g4lD-2yg6A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znm THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		3 ASN A  88
MET A  68
PHE A  30
 None
 1.08A 3g4lD-2znmA:
undetectable		 3g4lD-2znmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 ASN A 413
MET A 370
PHE A 400
 None
 0.70A 3g4lD-3aflA:
undetectable		 3g4lD-3aflA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0u UNCHARACTERIZED
PROTEIN YAEQ

(Escherichia
coli) 		PF07152
(YaeQ) 		3 ASN A 169
MET A 150
PHE A 145
 None
 1.15A 3g4lD-3c0uA:
undetectable		 3g4lD-3c0uA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 ASN B 386
MET B 368
PHE B 442
 None
 0.84A 3g4lD-3dw8B:
undetectable		 3g4lD-3dw8B:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 487
MET A 523
PHE A 538
 D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.67A 3g4lD-3g4gA:
52.7		 3g4lD-3g4gA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		3 ASN A  47
MET A 124
PHE A 118
 None
 1.09A 3g4lD-3gd9A:
undetectable		 3g4lD-3gd9A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 811
MET B 767
PHE B 840
 None
 0.99A 3g4lD-3h0gB:
undetectable		 3g4lD-3h0gB:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		3 ASN A 309
MET A 333
PHE A 287
 None
 0.74A 3g4lD-3hk0A:
undetectable		 3g4lD-3hk0A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8v H16.14J HEAVY CHAIN
H16.14J LIGHT CHAIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		3 ASN L  42
MET H 100
PHE H  91
 None
 1.02A 3g4lD-3j8vL:
undetectable		 3g4lD-3j8vL:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		3 ASN P 145
MET P   1
PHE P 117
 None
 0.97A 3g4lD-3j9tP:
undetectable		 3g4lD-3j9tP:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ASN X  60
MET X  70
PHE X  27
 None
 1.08A 3g4lD-3jb9X:
undetectable		 3g4lD-3jb9X:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG

(Homo sapiens) 		PF09174
(Maf1) 		3 ASN A 140
MET A   1
PHE A 142
 None
 0.99A 3g4lD-3nr5A:
undetectable		 3g4lD-3nr5A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwn KINESIN-LIKE PROTEIN
KIF9

(Homo sapiens) 		PF00225
(Kinesin) 		3 ASN A 146
MET A 166
PHE A 150
 None
 0.80A 3g4lD-3nwnA:
undetectable		 3g4lD-3nwnA:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 395
MET A 431
PHE A 446
 ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.6A)
 0.68A 3g4lD-3o57A:
52.2		 3g4lD-3o57A:
80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odn DALLY-LIKE PROTEIN

(Drosophila
melanogaster) 		PF01153
(Glypican) 		3 ASN A 187
MET A 213
PHE A 191
 None
 0.86A 3g4lD-3odnA:
undetectable		 3g4lD-3odnA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phf ENVELOPE
GLYCOPROTEIN H
ENVELOPE
GLYCOPROTEIN L

(Human
gammaherpesvirus
4;
Human
gammaherpesvirus
4) 		no annotation
no annotation 		3 ASN B 127
MET A  68
PHE B  59
 None
 1.08A 3g4lD-3phfB:
undetectable		 3g4lD-3phfB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4h PE FAMILY PROTEIN
LOW MOLECULAR WEIGHT
PROTEIN ANTIGEN 7

(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis) 		no annotation
PF06013
(WXG100) 		3 ASN B   7
MET B  18
PHE A  42
 None
 0.83A 3g4lD-3q4hB:
undetectable		 3g4lD-3q4hB:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 ASN A 474
MET A 525
PHE A 472
 None
 0.86A 3g4lD-3r6kA:
undetectable		 3g4lD-3r6kA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN

(Legionella
pneumophila) 		PF13407
(Peripla_BP_4) 		3 ASN A 209
MET A 225
PHE A 202
 None
 1.07A 3g4lD-3rotA:
undetectable		 3g4lD-3rotA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		3 ASN A 343
MET A   6
PHE A  53
 None
 1.11A 3g4lD-3tktA:
undetectable		 3g4lD-3tktA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaj ENVELOPE PROTEIN

(Dengue virus) 		no annotation 3 ASN B 128
MET B 260
PHE B 213
 None
 0.88A 3g4lD-3uajB:
undetectable		 3g4lD-3uajB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		3 ASN A 270
MET A 288
PHE A 336
 None
 0.81A 3g4lD-3vm7A:
undetectable		 3g4lD-3vm7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 ASN A 218
MET A 155
PHE A 195
 None
 1.02A 3g4lD-3vv3A:
undetectable		 3g4lD-3vv3A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuk ENDOPEPTIDASE,
PEPTIDASE FAMILY M13

(Mycobacterium
tuberculosis) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 ASN A 630
MET A 593
PHE A 639
 None
 1.06A 3g4lD-3zukA:
undetectable		 3g4lD-3zukA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 ASN A 748
MET A1170
PHE A1068
 None
 1.09A 3g4lD-4c3hA:
undetectable		 3g4lD-4c3hA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c53 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Guanarito
mammarenavirus) 		PF00798
(Arena_glycoprot) 		3 ASN A 307
MET A 400
PHE A 302
 NAG  A1407 ( 4.6A)
None
None
 1.10A 3g4lD-4c53A:
undetectable		 3g4lD-4c53A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0k A-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Chaetomium
thermophilum) 		no annotation 3 ASN A 228
MET A 235
PHE A 199
 None
 1.07A 3g4lD-4d0kA:
undetectable		 3g4lD-4d0kA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus) 		PF01979
(Amidohydro_1) 		3 ASN A 327
MET A 142
PHE A  65
 None
 1.15A 3g4lD-4f0lA:
undetectable		 3g4lD-4f0lA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 ASN B 773
MET B 178
PHE B 737
 None
 1.10A 3g4lD-4gnkB:
undetectable		 3g4lD-4gnkB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3w HYPOTHETICAL PROTEIN

(Parabacteroides
distasonis) 		PF15414
(DUF4621) 		3 ASN A 263
MET A 273
PHE A 340
 None
 1.14A 3g4lD-4h3wA:
undetectable		 3g4lD-4h3wA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		3 ASN A  23
MET A 211
PHE A 237
 None
 1.15A 3g4lD-4lgcA:
undetectable		 3g4lD-4lgcA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		3 ASN A 335
MET A 508
PHE A 318
 ONL  A 601 (-3.5A)
None
None
 1.14A 3g4lD-4o7dA:
undetectable		 3g4lD-4o7dA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		3 ASN A 453
MET A 484
PHE A 176
 None
 0.87A 3g4lD-4r1iA:
undetectable		 3g4lD-4r1iA:
20.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 ASN A 567
MET A 603
PHE A 618
 None
 0.89A 3g4lD-4wziA:
52.2		 3g4lD-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 3 ASN C 757
MET C 714
PHE C 754
 None
 0.83A 3g4lD-4wzsC:
undetectable		 3g4lD-4wzsC:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a08 PROBABLE
MANNOSYLTRANSFERASE
KTR4

(Saccharomyces
cerevisiae) 		PF01793
(Glyco_transf_15) 		3 ASN A 318
MET A 307
PHE A 323
 None
 1.09A 3g4lD-5a08A:
undetectable		 3g4lD-5a08A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ASN A1725
MET A1761
PHE A1745
 None
 1.15A 3g4lD-5a22A:
undetectable		 3g4lD-5a22A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 ASN A1532
MET A1024
PHE A1566
 None
 0.71A 3g4lD-5a31A:
undetectable		 3g4lD-5a31A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT M

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		3 ASN M 273
MET M 297
PHE M 311
 None
 0.82A 3g4lD-5a5tM:
undetectable		 3g4lD-5a5tM:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASN A 397
MET A 520
PHE A 376
 TPP  A 700 (-4.0A)
None
None
 1.01A 3g4lD-5ahkA:
undetectable		 3g4lD-5ahkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bza BETA-N-ACETYLHEXOSAM
INIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3) 		3 ASN A  81
MET A  98
PHE A  78
 None
 1.00A 3g4lD-5bzaA:
undetectable		 3g4lD-5bzaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkv ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		3 ASN A 172
MET A 191
PHE A 230
 None
 0.80A 3g4lD-5dkvA:
undetectable		 3g4lD-5dkvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA PRIMASE LARGE
SUBUNIT

(Homo sapiens) 		PF04104
(DNA_primase_lrg) 		3 ASN B 374
MET B 288
PHE B 365
 None
 1.02A 3g4lD-5exrB:
undetectable		 3g4lD-5exrB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo TRANSFORMING GROWTH
FACTOR BETA-1

(Homo sapiens) 		PF00019
(TGF_beta)
PF00688
(TGFb_propeptide) 		3 ASN C 155
MET C 104
PHE C 169
 None
 1.04A 3g4lD-5ffoC:
undetectable		 3g4lD-5ffoC:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASN H 159
MET L  37
PHE L 102
 None
 1.12A 3g4lD-5fhxH:
undetectable		 3g4lD-5fhxH:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP120 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		3 ASN G  94
MET G 271
PHE G 233
 None
 1.03A 3g4lD-5fyjG:
undetectable		 3g4lD-5fyjG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghu PROBABLE FIMBRIAL
CHAPERONE YADV

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		3 ASN A 219
MET A 190
PHE A 206
 None
 1.07A 3g4lD-5ghuA:
undetectable		 3g4lD-5ghuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 ASN A 104
MET A 132
PHE A 100
 None
 1.01A 3g4lD-5i0pA:
undetectable		 3g4lD-5i0pA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 822
MET B 778
PHE B 851
 None
 1.09A 3g4lD-5ip9B:
undetectable		 3g4lD-5ip9B:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE

(Acinetobacter
baumannii) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ASN A 110
MET A 100
PHE A  84
 None
 1.15A 3g4lD-5khaA:
undetectable		 3g4lD-5khaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF03279
(Lip_A_acyltrans) 		3 ASN B  74
MET B 129
PHE B 123
 None
 1.10A 3g4lD-5kn7B:
undetectable		 3g4lD-5kn7B:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		3 ASN A1532
MET A1024
PHE A1566
 None
 0.65A 3g4lD-5lcwA:
undetectable		 3g4lD-5lcwA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 115
MET A 243
PHE A 138
 None
ADP  A 901 (-3.5A)
None
 0.76A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		3 ASN A 826
MET A 707
PHE A 766
 None
 1.14A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myu TYPE VI SECRETION
SYSTEM PROTEIN IMPC

(Vibrio cholerae) 		PF05943
(VipB) 		3 ASN A 276
MET A 349
PHE A 243
 None
 0.86A 3g4lD-5myuA:
undetectable		 3g4lD-5myuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 3 ASN A 513
MET A 454
PHE A 497
 None
 1.16A 3g4lD-5ny0A:
undetectable		 3g4lD-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 3 ASN A 567
MET A 603
PHE A 618
 9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
 0.86A 3g4lD-5ohjA:
53.5		 3g4lD-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva DNA REPAIR HELICASE
RAD3

(Saccharomyces
cerevisiae) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		3 ASN Y 707
MET Y 537
PHE Y 529
 None
 1.11A 3g4lD-5svaY:
undetectable		 3g4lD-5svaY:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twt PEROXIDASE PVI9

(Panicum
virgatum) 		PF00141
(peroxidase) 		3 ASN A  68
MET A  32
PHE A  75
 None
None
SO4  A 304 (-4.5A)
 0.91A 3g4lD-5twtA:
undetectable		 3g4lD-5twtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASN A 223
MET A 173
PHE A 188
 None
 1.13A 3g4lD-5u8eA:
undetectable		 3g4lD-5u8eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Saccharomyces
cerevisiae) 		PF14629
(ORC4_C) 		3 ASN D 409
MET D 496
PHE D 499
 None
 1.14A 3g4lD-5udbD:
undetectable		 3g4lD-5udbD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2
CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
PF16679
(CDT1_C) 		3 ASN 8 157
MET 2 783
PHE 2 828
 None
 1.10A 3g4lD-5udb8:
undetectable		 3g4lD-5udb8:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmn BAK PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 ASN A   3
MET A  26
PHE A   6
 NO3  A 206 (-4.8A)
None
NO3  A 206 ( 4.6A)
 0.81A 3g4lD-5vmnA:
undetectable		 3g4lD-5vmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 3 ASN A  99
MET A 172
PHE A  94
 None
 0.99A 3g4lD-5weaA:
undetectable		 3g4lD-5weaA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASN B 822
MET B 778
PHE B 851
 None
 1.10A 3g4lD-5xogB:
undetectable		 3g4lD-5xogB:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0e 1260 ANTIBODY, HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 ASN B  76
MET B  69
PHE B  34
 None
 1.04A 3g4lD-6b0eB:
undetectable		 3g4lD-6b0eB:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4o GLUTATHIONE
REDUCTASE

(Enterococcus
faecalis) 		no annotation 3 ASN A 227
MET A 222
PHE A 196
 None
 1.07A 3g4lD-6b4oA:
undetectable		 3g4lD-6b4oA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 3 ASN D 339
MET D 278
PHE D 332
 None
 0.84A 3g4lD-6eojD:
undetectable		 3g4lD-6eojD:
21.10