SIMILAR PATTERNS OF AMINO ACIDS FOR 3G4L_C_ROFC903_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqj SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		3 SER A  18
GLN A  19
PHE A  22
 COA  A 901 (-3.1A)
COA  A 901 (-4.9A)
None
 0.54A 3g4lC-1cqjA:
0.2		 3g4lC-1cqjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ioj APOC-I

(Homo sapiens) 		PF04691
(ApoC-I) 		3 SER A  43
GLN A  47
PHE A  46
 None
 0.76A 3g4lC-1iojA:
undetectable		 3g4lC-1iojA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		3 SER A  73
GLN A  60
PHE A  71
 None
 0.82A 3g4lC-1jl0A:
0.0		 3g4lC-1jl0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		3 SER A 302
GLN A 301
PHE A 304
 None
 0.81A 3g4lC-1k9xA:
1.0		 3g4lC-1k9xA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A  45
GLN A  44
PHE A  47
 None
 0.82A 3g4lC-1kfiA:
0.0		 3g4lC-1kfiA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		3 SER A 352
GLN A 255
PHE A 351
 None
 0.63A 3g4lC-1oa1A:
0.5		 3g4lC-1oa1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 SER A  91
GLN A  90
PHE A  93
 None
BVP  A 500 (-3.0A)
BVP  A 500 (-3.5A)
 0.83A 3g4lC-1osnA:
0.0		 3g4lC-1osnA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		3 SER A 103
GLN A 102
PHE A 105
 None
T5A  A 501 (-3.1A)
T5A  A 501 (-3.4A)
 0.80A 3g4lC-1p75A:
0.0		 3g4lC-1p75A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqq ADAPTOR PROTEIN APS

(Rattus
norvegicus) 		PF00017
(SH2) 		3 SER C 478
GLN C 477
PHE C 480
 None
 0.84A 3g4lC-1rqqC:
undetectable		 3g4lC-1rqqC:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uff INTERSECTIN 2

(Homo sapiens) 		PF14604
(SH3_9) 		3 SER A  46
GLN A  31
PHE A  47
 None
 0.72A 3g4lC-1uffA:
undetectable		 3g4lC-1uffA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		3 SER A 345
GLN A 251
PHE A 344
 None
 0.68A 3g4lC-1upxA:
0.0		 3g4lC-1upxA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn4 RIBONUCLEASE MAR1

(Leishmania
major) 		PF00857
(Isochorismatase) 		3 SER A  86
GLN A 115
PHE A  85
 None
 0.70A 3g4lC-1xn4A:
0.0		 3g4lC-1xn4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyn ENDO-1,4-BETA-XYLANA
SE I

(Trichoderma
reesei) 		PF00457
(Glyco_hydro_11) 		3 SER A 175
GLN A 174
PHE A  50
 None
 0.40A 3g4lC-1xynA:
undetectable		 3g4lC-1xynA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		3 SER A  54
GLN A  55
PHE A  58
 None
 0.68A 3g4lC-1y3nA:
undetectable		 3g4lC-1y3nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		3 SER A 245
GLN A 246
PHE A 249
 None
 0.58A 3g4lC-1yisA:
undetectable		 3g4lC-1yisA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytz TROPONIN I

(Gallus gallus) 		PF00992
(Troponin) 		3 SER I  96
GLN I  97
PHE I 100
 None
 0.72A 3g4lC-1ytzI:
undetectable		 3g4lC-1ytzI:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yv0 TROPONIN I, FAST
SKELETAL MUSCLE

(Gallus gallus) 		PF00992
(Troponin) 		3 SER I  96
GLN I  97
PHE I 100
 None
 0.74A 3g4lC-1yv0I:
undetectable		 3g4lC-1yv0I:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmb ACETYLXYLAN ESTERASE
RELATED ENZYME

(Clostridium
acetobutylicum) 		PF03629
(SASA) 		3 SER A 212
GLN A 213
PHE A 216
 None
 0.67A 3g4lC-1zmbA:
undetectable		 3g4lC-1zmbA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae) 		PF00578
(AhpC-TSA) 		3 SER A 137
GLN A 138
PHE A 141
 None
 0.57A 3g4lC-2a4vA:
undetectable		 3g4lC-2a4vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		3 SER A 361
GLN A 362
PHE A 365
 None
 0.72A 3g4lC-2ahwA:
undetectable		 3g4lC-2ahwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE

(Campylobacter
jejuni) 		PF08761
(dUTPase_2) 		3 SER A 109
GLN A 112
PHE A 111
 None
 0.80A 3g4lC-2cicA:
undetectable		 3g4lC-2cicA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inc TOLUENE, O-XYLENE
MONOOXYGENASE
OXYGENASE SUBUNIT

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		3 SER A 289
GLN A 288
PHE A 293
 None
None
P6G  A 503 ( 4.5A)
 0.83A 3g4lC-2incA:
undetectable		 3g4lC-2incA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		3 SER A 216
GLN A 217
PHE A 191
 None
None
SO4  A1439 (-4.8A)
 0.85A 3g4lC-2j3zA:
undetectable		 3g4lC-2j3zA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 SER A 183
GLN A 212
PHE A 182
 None
 0.71A 3g4lC-2lbpA:
undetectable		 3g4lC-2lbpA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 SER A 183
GLN A 212
PHE A 182
 None
 0.58A 3g4lC-2livA:
undetectable		 3g4lC-2livA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mty STARP ANTIGEN

(Plasmodium
falciparum) 		no annotation 3 SER A  13
GLN A  12
PHE A  15
 None
 0.85A 3g4lC-2mtyA:
undetectable		 3g4lC-2mtyA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		3 SER A 107
GLN A 111
PHE A 110
 None
DTP  A 301 (-2.9A)
DTP  A 301 (-4.2A)
 0.77A 3g4lC-2ocpA:
undetectable		 3g4lC-2ocpA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 SER A  75
GLN A  74
PHE A  71
 None
 0.78A 3g4lC-2oerA:
undetectable		 3g4lC-2oerA:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 580
GLN A 581
PHE A 584
 NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.22A 3g4lC-2qykA:
52.2		 3g4lC-2qykA:
85.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		3 SER A 219
GLN A 217
PHE A 255
 UFP  A 529 (-3.4A)
UFP  A 529 ( 4.7A)
None
 0.71A 3g4lC-2tddA:
undetectable		 3g4lC-2tddA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whd THIOREDOXIN
REDUCTASE

(Hordeum vulgare) 		PF07992
(Pyr_redox_2) 		3 SER A 100
GLN A 265
PHE A  99
 None
 0.79A 3g4lC-2whdA:
undetectable		 3g4lC-2whdA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		3 SER A 388
GLN A 387
PHE A 361
 None
 0.81A 3g4lC-2x24A:
undetectable		 3g4lC-2x24A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b77 UNCHARACTERIZED
PROTEIN

(Exiguobacterium
sibiricum) 		PF08000
(bPH_1)
PF11724
(YvbH_ext) 		3 SER A 175
GLN A 176
PHE A 179
 None
 0.51A 3g4lC-3b77A:
undetectable		 3g4lC-3b77A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg0 NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		3 SER B 534
GLN B 535
PHE B 538
 None
 0.50A 3g4lC-3bg0B:
undetectable		 3g4lC-3bg0B:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		3 SER A 350
GLN A 353
PHE A 352
 None
 0.83A 3g4lC-3d3lA:
undetectable		 3g4lC-3d3lA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 SER A  99
GLN A 115
PHE A  97
 None
 0.67A 3g4lC-3dsmA:
undetectable		 3g4lC-3dsmA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		3 SER A 299
GLN A 298
PHE A 301
 CO  A 999 ( 3.9A)
None
None
 0.82A 3g4lC-3dwcA:
undetectable		 3g4lC-3dwcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzt D7 PROTEIN

(Aedes aegypti) 		PF01395
(PBP_GOBP) 		3 SER A 152
GLN A 151
PHE A 156
 None
 0.85A 3g4lC-3dztA:
undetectable		 3g4lC-3dztA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 777
GLN A 778
PHE A 781
 None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
 0.22A 3g4lC-3ecnA:
44.8		 3g4lC-3ecnA:
32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 SER A  80
GLN A  79
PHE A  82
 None
 0.61A 3g4lC-3egoA:
undetectable		 3g4lC-3egoA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		3 SER A 373
GLN A 372
PHE A 369
 None
 0.69A 3g4lC-3ei8A:
undetectable		 3g4lC-3ei8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF01536
(SAM_decarbox)
PF01536
(SAM_decarbox) 		3 SER A  73
GLN B  60
PHE A  71
 None
 0.81A 3g4lC-3ep7A:
undetectable		 3g4lC-3ep7A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		3 SER A2063
GLN A2062
PHE A2036
 None
 0.75A 3g4lC-3ff6A:
undetectable		 3g4lC-3ff6A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 SER A 330
GLN A 334
PHE A 333
 None
 0.79A 3g4lC-3fxgA:
undetectable		 3g4lC-3fxgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		3 SER A 123
GLN A 121
PHE A 124
 None
 0.69A 3g4lC-3gseA:
undetectable		 3g4lC-3gseA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		3 SER A 298
GLN A 297
PHE A 300
 ZN  A 502 ( 3.7A)
None
None
 0.76A 3g4lC-3hq2A:
undetectable		 3g4lC-3hq2A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		3 SER A 416
GLN A 415
PHE A 417
 None
 0.77A 3g4lC-3i4xA:
undetectable		 3g4lC-3i4xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6d PROTOPORPHYRINOGEN
OXIDASE

(Bacillus
subtilis) 		PF01593
(Amino_oxidase) 		3 SER A 151
GLN A 150
PHE A 155
 None
PO4  A 472 (-2.8A)
None
 0.81A 3g4lC-3i6dA:
undetectable		 3g4lC-3i6dA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icq EXPORTIN-T

(Schizosaccharomyces
pombe) 		PF08389
(Xpo1) 		3 SER T 141
GLN T 140
PHE T 143
 None
 0.85A 3g4lC-3icqT:
undetectable		 3g4lC-3icqT:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipc ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (AMINO ACID)

(Agrobacterium
fabrum) 		PF13458
(Peripla_BP_6) 		3 SER A 183
GLN A 212
PHE A 182
 None
 0.78A 3g4lC-3ipcA:
undetectable		 3g4lC-3ipcA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		3 SER A1535
GLN A1536
PHE A1539
 None
 0.60A 3g4lC-3jroA:
undetectable		 3g4lC-3jroA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp5 PUTATIVE CELL
SURFACE HYDROLASE

(Lactobacillus
plantarum) 		PF06028
(DUF915) 		3 SER A  15
GLN A  16
PHE A  19
 None
 0.75A 3g4lC-3lp5A:
undetectable		 3g4lC-3lp5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		3 SER B 188
GLN B 191
PHE B 190
 None
 0.68A 3g4lC-3mcaB:
undetectable		 3g4lC-3mcaB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		3 SER A 207
GLN A 236
PHE A 206
 None
 0.79A 3g4lC-3n0wA:
undetectable		 3g4lC-3n0wA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5b ASR0485 PROTEIN

(Nostoc sp. PCC
7120) 		PF12058
(DUF3539) 		3 SER B  85
GLN B  84
PHE B  87
 None
 0.81A 3g4lC-3n5bB:
undetectable		 3g4lC-3n5bB:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 SER A 311
GLN A 271
PHE A 142
 None
 0.56A 3g4lC-3nwrA:
undetectable		 3g4lC-3nwrA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 442
GLN A 443
PHE A 446
 None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
 0.43A 3g4lC-3o57A:
51.7		 3g4lC-3o57A:
80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 SER A  34
GLN A  33
PHE A  36
 None
 0.64A 3g4lC-3ov3A:
undetectable		 3g4lC-3ov3A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 368
GLN A 369
PHE A 372
 SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
 0.45A 3g4lC-3sl5A:
53.0		 3g4lC-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3td9 BRANCHED CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Thermotoga
maritima) 		PF13458
(Peripla_BP_6) 		3 SER A 198
GLN A 227
PHE A 197
 None
 0.63A 3g4lC-3td9A:
undetectable		 3g4lC-3td9A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		3 SER A  93
GLN A 122
PHE A  92
 None
 0.76A 3g4lC-3tqsA:
undetectable		 3g4lC-3tqsA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u3i NUCLEOCAPSID PROTEIN

(Crimean-Congo
hemorrhagic
fever
orthonairovirus) 		PF02477
(Nairo_nucleo) 		3 SER A 328
GLN A 329
PHE A 332
 None
 0.81A 3g4lC-3u3iA:
undetectable		 3g4lC-3u3iA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		3 SER A 569
GLN A 570
PHE A 573
 None
WYQ  A 701 (-3.3A)
WYQ  A 701 (-3.4A)
 0.56A 3g4lC-3v94A:
39.7		 3g4lC-3v94A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		3 SER A  68
GLN A  69
PHE A  72
 None
 0.82A 3g4lC-3w4kA:
undetectable		 3g4lC-3w4kA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 SER A  69
GLN A  67
PHE A  71
 None
 0.85A 3g4lC-4adeA:
undetectable		 3g4lC-4adeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		3 SER A 354
GLN A 353
PHE A 356
 None
 0.84A 3g4lC-4cq1A:
undetectable		 3g4lC-4cq1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0n A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 SER B2054
GLN B2058
PHE B2057
 None
 0.82A 3g4lC-4d0nB:
undetectable		 3g4lC-4d0nB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq1 THYMIDYLATE SYNTHASE

(Staphylococcus
aureus) 		PF00303
(Thymidylat_synt) 		3 SER A 222
GLN A 220
PHE A 258
 UMP  A 501 (-2.5A)
UMP  A 501 (-4.1A)
None
 0.73A 3g4lC-4dq1A:
undetectable		 3g4lC-4dq1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evm THIOREDOXIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00578
(AhpC-TSA) 		3 SER A 120
GLN A 119
PHE A 124
 None
 0.82A 3g4lC-4evmA:
undetectable		 3g4lC-4evmA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqs THIOREDOXIN FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00578
(AhpC-TSA) 		3 SER A 120
GLN A 119
PHE A 124
 None
MG  A 209 ( 4.4A)
None
 0.79A 3g4lC-4hqsA:
undetectable		 3g4lC-4hqsA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilq CT771

(Chlamydia
trachomatis) 		PF00293
(NUDIX) 		3 SER A 145
GLN A 144
PHE A 148
 None
 0.75A 3g4lC-4ilqA:
undetectable		 3g4lC-4ilqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		3 SER A 559
GLN A 536
PHE A 557
 None
 0.69A 3g4lC-4iovA:
undetectable		 3g4lC-4iovA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		3 SER A   0
GLN A  -1
PHE A  -2
 None
 0.78A 3g4lC-4juuA:
undetectable		 3g4lC-4juuA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 3 SER H 294
GLN H 253
PHE H 293
 None
 0.73A 3g4lC-4l0oH:
undetectable		 3g4lC-4l0oH:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		3 SER A 163
GLN A 162
PHE A 167
 None
 0.81A 3g4lC-4m46A:
undetectable		 3g4lC-4m46A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0q LEU/ILE/VAL-BINDING
PROTEIN HOMOLOG 3

(Brucella
melitensis) 		PF13458
(Peripla_BP_6) 		3 SER A 205
GLN A 234
PHE A 204
 None
 0.42A 3g4lC-4n0qA:
undetectable		 3g4lC-4n0qA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		3 SER A 861
GLN A 860
PHE A 863
 None
 0.62A 3g4lC-4n3nA:
undetectable		 3g4lC-4n3nA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 SER A 289
GLN A 288
PHE A 293
 None
 0.80A 3g4lC-4p1cA:
undetectable		 3g4lC-4p1cA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		3 SER A 229
GLN A 228
PHE A 231
 None
 0.83A 3g4lC-4repA:
undetectable		 3g4lC-4repA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rp5 DISKS LARGE 1 TUMOR
SUPPRESSOR PROTEIN

(Drosophila
melanogaster) 		PF09058
(L27_1) 		3 SER A  43
GLN A  47
PHE A  46
 None
 0.83A 3g4lC-4rp5A:
undetectable		 3g4lC-4rp5A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1n PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Streptococcus
pneumoniae) 		PF00551
(Formyl_trans_N) 		3 SER A  13
GLN A  16
PHE A  15
 CL  A 202 (-4.1A)
None
None
 0.80A 3g4lC-4s1nA:
undetectable		 3g4lC-4s1nA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		3 SER A 391
GLN A 390
PHE A 393
 None
 0.80A 3g4lC-4s3jA:
undetectable		 3g4lC-4s3jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		3 SER A 226
GLN A 227
PHE A 230
 None
None
TRP  A 601 (-4.4A)
 0.66A 3g4lC-4us4A:
undetectable		 3g4lC-4us4A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 614
GLN A 615
PHE A 618
 None
 0.20A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 SER A  13
GLN A  12
PHE A  15
 None
 0.84A 3g4lC-4x4wA:
undetectable		 3g4lC-4x4wA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 3 SER A  84
GLN A  83
PHE A  86
 None
EDO  A1295 ( 4.9A)
None
 0.85A 3g4lC-5a3cA:
undetectable		 3g4lC-5a3cA:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		3 SER A 420
GLN A 421
PHE A 424
 4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
 0.54A 3g4lC-5b25A:
43.5		 3g4lC-5b25A:
37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		3 SER A 163
GLN A 162
PHE A 167
 None
 0.72A 3g4lC-5gyzA:
undetectable		 3g4lC-5gyzA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		3 SER A  54
GLN A  55
PHE A  58
 None
 0.56A 3g4lC-5h71A:
undetectable		 3g4lC-5h71A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha8 ISOCHORISMATASE

(Microbacterium
hydrocarbonoxydans) 		PF00857
(Isochorismatase) 		3 SER A 108
GLN A 107
PHE A 110
 None
 0.84A 3g4lC-5ha8A:
undetectable		 3g4lC-5ha8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 SER A 163
GLN A 162
PHE A 167
 None
 0.68A 3g4lC-5kyvA:
undetectable		 3g4lC-5kyvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL5C

(Spinacia
oleracea) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		3 SER F 189
GLN F 188
PHE F 191
 None
 0.53A 3g4lC-5mmiF:
undetectable		 3g4lC-5mmiF:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 3 SER A 614
GLN A 615
PHE A 618
 9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
 0.18A 3g4lC-5ohjA:
52.1		 3g4lC-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmn BAK PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 3 SER A  73
GLN A  74
PHE A  77
 None
 0.69A 3g4lC-5vmnA:
undetectable		 3g4lC-5vmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 SER C2046
GLN C2042
PHE C2045
 None
 0.67A 3g4lC-5y3rC:
undetectable		 3g4lC-5y3rC:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1

(Yarrowia
lipolytica) 		no annotation 3 SER A 538
GLN A 539
PHE A 542
 FAD  A 701 ( 4.9A)
None
None
 0.69A 3g4lC-5y9dA:
undetectable		 3g4lC-5y9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6auj THYMIDYLATE SYNTHASE

(Elizabethkingia
anophelis) 		PF00303
(Thymidylat_synt) 		3 SER A 175
GLN A 173
PHE A 211
 M0H  A 154 ( 4.2A)
None
None
 0.83A 3g4lC-6aujA:
undetectable		 3g4lC-6aujA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axg RAS GUANYL-RELEASING
PROTEIN 4

(Homo sapiens) 		no annotation 3 SER A  71
GLN A 120
PHE A  69
 None
 0.50A 3g4lC-6axgA:
undetectable		 3g4lC-6axgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 SER A1177
GLN A1176
PHE A1173
 None
 0.76A 3g4lC-6bhuA:
undetectable		 3g4lC-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eks SIALIDASE

(Vibrio cholerae) 		no annotation 3 SER A 382
GLN A 518
PHE A 535
 None
 0.83A 3g4lC-6eksA:
undetectable		 3g4lC-6eksA:
18.29