SIMILAR PATTERNS OF AMINO ACIDS FOR 3G4L_C_ROFC903_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 207
PRO A 209
TYR A 334
THR A 330
ILE A 327
 None
 1.28A 3g4lC-1g1aA:
undetectable		 3g4lC-1g1aA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
 0.49A 3g4lC-1sojA:
41.6		 3g4lC-1sojA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		5 TYR R  70
LEU R 104
PRO R 125
THR R 135
ILE R 139
 None
 1.16A 3g4lC-1y6nR:
undetectable		 3g4lC-1y6nR:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		5 ASP A 490
LEU A 488
TYR A 520
THR A 535
ILE A 427
 None
 1.30A 3g4lC-1z45A:
undetectable		 3g4lC-1z45A:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
ASP A 362
ASN A 365
PRO A 366
TRP A 376
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 ( 4.7A)
None
None
 0.25A 3g4lC-1zklA:
45.3		 3g4lC-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 191
PRO A 193
TYR A 311
THR A 307
ILE A 304
 None
 1.24A 3g4lC-2hunA:
undetectable		 3g4lC-2hunA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
ASN A 533
PRO A 534
TYR A 541
TRP A 544
THR A 545
ILE A 548
MET A 569
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
NPV  A   3 (-4.4A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
 0.42A 3g4lC-2qykA:
52.2		 3g4lC-2qykA:
85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
ASN A 443
PRO A 444
TYR A 451
TRP A 454
THR A 455
ILE A 458
 None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
None
 0.54A 3g4lC-2qymA:
43.5		 3g4lC-2qymA:
83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
MET A 797
ASP A 835
ASN A 838
TRP A 849
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
IBM  A   3 (-4.5A)
None
 0.41A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lC-2r8qA:
38.9		 3g4lC-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF07653
(SH3_2)
PF16172
(DOCK_N) 		5 ASP A 162
LEU A 163
THR A 149
ILE A 152
MET A 120
 None
 1.50A 3g4lC-3a98A:
undetectable		 3g4lC-3a98A:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 555
HIS A 556
MET A 670
ASP A 726
ASN A 729
PRO A 730
TRP A 740
ILE A 744
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
None
IBM  A   3 (-4.3A)
 0.31A 3g4lC-3ecnA:
44.8		 3g4lC-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
ASN A 487
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.5A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
 0.66A 3g4lC-3g4gA:
52.7		 3g4lC-3g4gA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
 None
None
ZN  A   1 (-2.7A)
None
None
 0.72A 3g4lC-3ibjA:
32.5		 3g4lC-3ibjA:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
 None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
None
 0.85A 3g4lC-3n3zA:
41.1		 3g4lC-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
ASN A 395
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 431
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
 0.33A 3g4lC-3o57A:
51.7		 3g4lC-3o57A:
80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
 PDB  A 600 (-4.6A)
PDB  A 600 ( 4.7A)
ZN  A 534 (-2.7A)
PDB  A 600 (-4.4A)
None
 0.55A 3g4lC-3qi3A:
41.6		 3g4lC-3qi3A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
 0.46A 3g4lC-3sl5A:
53.0		 3g4lC-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
 0.59A 3g4lC-3ui7A:
38.0		 3g4lC-3ui7A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		6 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
 0.63A 3g4lC-3v94A:
39.7		 3g4lC-3v94A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 TYR A3601
LEU A3181
TYR A3233
THR A3237
ILE A3238
 None
 1.48A 3g4lC-3vkgA:
undetectable		 3g4lC-3vkgA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
 None
None
ZN  A1001 (-2.5A)
None
None
 0.52A 3g4lC-4htzA:
38.5		 3g4lC-4htzA:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
MET A 785
ASP A 822
ASN A 825
TRP A 836
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.39A 3g4lC-4i15A:
38.2		 3g4lC-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.39A 3g4lC-4i15A:
38.2		 3g4lC-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.68A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.55A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.59A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
 0.41A 3g4lC-4wziA:
52.4		 3g4lC-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		5 HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
 None
 1.12A 3g4lC-4z0xB:
undetectable		 3g4lC-4z0xB:
15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		7 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
 0.50A 3g4lC-5b25A:
43.5		 3g4lC-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
MET A 785
ASP A 823
ASN A 826
TRP A 837
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-4.4A)
None
 0.40A 3g4lC-5h2rA:
38.9		 3g4lC-5h2rA:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 5 TYR A 668
HIS A 669
MET A 785
ASP A 823
THR A 842
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
LLN  A1003 (-3.6A)
 1.33A 3g4lC-5h2rA:
38.9		 3g4lC-5h2rA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 HIS A 148
ASP A 189
LEU A 220
ILE A 127
MET A  36
 None
 1.38A 3g4lC-5h42A:
undetectable		 3g4lC-5h42A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 5 MET A 230
LEU A 226
TYR A 266
THR A 256
ILE A 257
 None
 0.96A 3g4lC-5n81A:
undetectable		 3g4lC-5n81A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
 None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
 0.26A 3g4lC-5ohjA:
52.1		 3g4lC-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 9 TYR A 405
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
MET A 603
 None
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
 0.55A 3g4lC-5ohjA:
52.1		 3g4lC-5ohjA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 6 HIS A  83
MET A 195
ASP A 236
LEU A 237
ASN A 239
PRO A 240
 None
None
ZN  A 401 (-2.4A)
None
None
None
 0.75A 3g4lC-5vydA:
39.7		 3g4lC-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 5 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
 None
None
ZN  A 401 (-2.4A)
None
None
 0.49A 3g4lC-5vydA:
39.7		 3g4lC-5vydA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
 0.45A 3g4lC-5wh6A:
54.4		 3g4lC-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ASP A  98
LEU A  96
TYR A  45
THR A  49
ILE A  55
 None
 1.36A 3g4lC-6f8zA:
undetectable		 3g4lC-6f8zA:
undetectable