SIMILAR PATTERNS OF AMINO ACIDS FOR 3G4L_B_ROFB902

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HNA  A 351 (-3.8A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.6A)
 1.42A 3g4lB-1m2pA:
undetectable		 3g4lB-1m2pA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
 IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
 0.48A 3g4lB-1sojA:
41.7		 3g4lB-1sojA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		5 MET D  61
LEU D  58
PRO D 132
ILE D  92
MET D  88
 None
 1.38A 3g4lB-1sxjD:
undetectable		 3g4lB-1sxjD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		5 TYR A 151
LEU A  89
PRO A 136
ILE A 150
PHE A 142
 None
 1.37A 3g4lB-1wkpA:
undetectable		 3g4lB-1wkpA:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
 IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
 0.44A 3g4lB-1zklA:
45.4		 3g4lB-1zklA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 ASP A 156
LEU A  66
ILE A 159
MET A 181
PHE A 283
 None
 1.36A 3g4lB-2ozeA:
undetectable		 3g4lB-2ozeA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TRP A 544
THR A 545
ILE A 548
MET A 549
MET A 569
PHE A 584
 NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
 0.41A 3g4lB-2qykA:
52.0		 3g4lB-2qykA:
85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		10 TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TRP A 454
THR A 455
ILE A 458
PHE A 494
 None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
 0.55A 3g4lB-2qymA:
43.1		 3g4lB-2qymA:
83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 281
PRO A 444
TRP A 454
THR A 455
MET A 459
 None
 0.96A 3g4lB-2qymA:
43.1		 3g4lB-2qymA:
83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 TYR A 680
HIS A 681
MET A 797
ASP A 835
THR A 854
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
 1.27A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		6 TYR A 680
HIS A 681
MET A 797
ASP A 835
TRP A 849
PHE A 890
 IBM  A   3 ( 4.7A)
IBM  A   3 ( 4.8A)
None
ZN  A   1 (-2.6A)
None
IBM  A   3 (-3.6A)
 0.41A 3g4lB-2r8qA:
38.9		 3g4lB-2r8qA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF07653
(SH3_2)
PF16172
(DOCK_N) 		5 ASP A 162
LEU A 163
THR A 149
ILE A 152
MET A 120
 None
 1.47A 3g4lB-3a98A:
undetectable		 3g4lB-3a98A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
 0.61A 3g4lB-3b2rA:
31.6		 3g4lB-3b2rA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
 None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
 0.59A 3g4lB-3bjcA:
34.3		 3g4lB-3bjcA:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
PHE A 781
 None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.5A)
 0.33A 3g4lB-3ecnA:
44.8		 3g4lB-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 330
MET A 439
LEU A 485
MET A 503
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 1.24A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
MET A 523
PHE A 538
 None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
 0.58A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
PHE A 538
 None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
 0.59A 3g4lB-3g4gA:
52.7		 3g4lB-3g4gA:
74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
 None
None
ZN  A   1 (-2.7A)
None
None
None
 0.92A 3g4lB-3ibjA:
32.7		 3g4lB-3ibjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		5 MET X 745
LEU X1032
THR X 990
ILE X 989
PHE X 642
 None
 1.41A 3g4lB-3jb9X:
undetectable		 3g4lB-3jb9X:
14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
 None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.4A)
 0.60A 3g4lB-3n3zA:
41.0		 3g4lB-3n3zA:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TRP A 406
THR A 407
ILE A 410
MET A 411
MET A 431
PHE A 446
 None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.6A)
 0.50A 3g4lB-3o57A:
51.5		 3g4lB-3o57A:
80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 LEU X 368
PRO X 276
THR X 344
ILE X 342
PHE X 278
 None
 1.49A 3g4lB-3pb9X:
undetectable		 3g4lB-3pb9X:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
 PDB  A 600 (-4.6A)
PDB  A 600 ( 4.7A)
ZN  A 534 (-2.7A)
None
PDB  A 600 (-3.5A)
 0.59A 3g4lB-3qi3A:
41.4		 3g4lB-3qi3A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
 TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
MET  A 357 (-0.0A)
PHE  A 372 (-1.3A)
 0.53A 3g4lB-3sl5A:
52.8		 3g4lB-3sl5A:
98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 729
 C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
 0.83A 3g4lB-3ui7A:
38.2		 3g4lB-3ui7A:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v94 CYCLIC NUCLEOTIDE
SPECIFIC
PHOSPHODIESTERASE

(Trypanosoma
cruzi) 		PF00233
(PDEase_I) 		7 TYR A 367
HIS A 368
MET A 482
ASP A 521
TRP A 535
ILE A 538
PHE A 573
 WYQ  A 701 (-4.5A)
None
WYQ  A 701 (-4.5A)
ZN  A 702 (-1.9A)
None
WYQ  A 701 ( 4.1A)
WYQ  A 701 (-3.4A)
 0.78A 3g4lB-3v94A:
39.8		 3g4lB-3v94A:
30.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		6 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
 None
None
ZN  A1001 (-2.5A)
None
None
None
 0.58A 3g4lB-4htzA:
38.6		 3g4lB-4htzA:
27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		5 TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
 None
 0.99A 3g4lB-4htzA:
38.6		 3g4lB-4htzA:
27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		5 TYR A 668
HIS A 669
MET A 785
ASP A 822
THR A 841
 None
None
None
ZN  A1001 (-2.5A)
None
 1.38A 3g4lB-4i15A:
38.2		 3g4lB-4i15A:
32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4i15 CLASS 1
PHOSPHODIESTERASE
PDEB1

(Trypanosoma
brucei) 		PF00233
(PDEase_I) 		6 TYR A 668
HIS A 669
MET A 785
ASP A 822
TRP A 836
PHE A 877
 None
None
None
ZN  A1001 (-2.5A)
None
None
 0.46A 3g4lB-4i15A:
38.2		 3g4lB-4i15A:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 HIS A 193
LEU A  86
ILE A 213
MET A 202
PHE A 152
 None
None
GNP  A 401 (-4.6A)
GNP  A 401 (-3.6A)
None
 1.43A 3g4lB-4jr7A:
undetectable		 3g4lB-4jr7A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS E 154
LEU E  85
ILE E 174
MET E 163
PHE E 113
 None
 1.32A 3g4lB-4md8E:
undetectable		 3g4lB-4md8E:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
MET A 603
PHE A 618
 None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
 0.73A 3g4lB-4wziA:
52.2		 3g4lB-4wziA:
47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		PF00233
(PDEase_I) 		11 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
PHE A 618
 None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
 0.58A 3g4lB-4wziA:
52.2		 3g4lB-4wziA:
47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		5 HIS A 104
ASP A 265
LEU A 266
THR A 182
PHE A 189
 None
 1.41A 3g4lB-4y9sA:
undetectable		 3g4lB-4y9sA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B

(Homo sapiens) 		PF00233
(PDEase_I) 		8 TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
PHE A 424
 None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-3.5A)
 0.48A 3g4lB-5b25A:
43.6		 3g4lB-5b25A:
37.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h2r PHOSPHODIESTERASE

(Trypanosoma
brucei) 		no annotation 6 TYR A 668
HIS A 669
MET A 785
ASP A 823
TRP A 837
PHE A 878
 LLN  A1003 ( 4.8A)
None
LLN  A1003 (-4.0A)
ZN  A1001 (-2.6A)
None
LLN  A1003 (-3.8A)
 0.43A 3g4lB-5h2rA:
38.9		 3g4lB-5h2rA:
31.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
 None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
 1.41A 3g4lB-5movA:
undetectable		 3g4lB-5movA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
PHE A 618
 None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.9A)
 0.26A 3g4lB-5ohjA:
52.0		 3g4lB-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B

(Homo sapiens) 		no annotation 11 TYR A 405
HIS A 406
MET A 519
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
MET A 603
PHE A 618
 None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
 0.52A 3g4lB-5ohjA:
52.0		 3g4lB-5ohjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj3 -

(-) 		no annotation 5 ASP A 251
LEU A 254
PRO A 305
THR A 295
PHE A 292
 None
 1.31A 3g4lB-5oj3A:
undetectable		 3g4lB-5oj3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 6 HIS A  83
MET A 195
ASP A 236
LEU A 237
PRO A 240
PHE A 291
 None
None
ZN  A 401 (-2.4A)
None
None
None
 0.51A 3g4lB-5vydA:
39.8		 3g4lB-5vydA:
30.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta) 		no annotation 6 HIS A  83
MET A 195
ASP A 236
LEU A 237
TRP A 250
PHE A 291
 None
None
ZN  A 401 (-2.4A)
None
None
None
 0.61A 3g4lB-5vydA:
39.8		 3g4lB-5vydA:
30.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		no annotation 12 TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
 AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
 0.43A 3g4lB-5wh6A:
54.0		 3g4lB-5wh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 HIS A 158
LEU A  89
ILE A 178
MET A 167
PHE A 117
 None
None
ATP  A 403 ( 4.5A)
ATP  A 403 ( 3.7A)
None
 1.48A 3g4lB-5xvuA:
undetectable		 3g4lB-5xvuA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9x SMALL RNA DEGRADING
NUCLEASE 1

(Arabidopsis
thaliana) 		no annotation 5 HIS A 236
LEU A  85
THR A 138
ILE A 219
MET A 140
 None
 1.31A 3g4lB-5z9xA:
undetectable		 3g4lB-5z9xA:
undetectable