SIMILAR PATTERNS OF AMINO ACIDS FOR 3G2O_B_SAMB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		5 ALA A  73
GLY A  83
LEU A  42
SER A  87
GLY A  23
 None
 1.08A 3g2oB-1c3lA:
2.4		 3g2oB-1c3lA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 215
GLY A 190
SER A 267
GLY A 268
SER A 269
 None
 1.05A 3g2oB-1dabA:
undetectable		 3g2oB-1dabA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		5 GLU A  89
LEU A  92
LEU A 108
GLY A 186
SER A 181
 None
 1.07A 3g2oB-1fd9A:
undetectable		 3g2oB-1fd9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 342
LEU A 409
LEU A 413
SER A 348
SER A 301
 None
 1.03A 3g2oB-1gz7A:
undetectable		 3g2oB-1gz7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 ALA A 118
LEU A 116
SER A   9
GLY A 121
GLU A 123
 None
 0.88A 3g2oB-1hyqA:
3.0		 3g2oB-1hyqA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 ALA A 363
GLY A 361
ASP A 225
GLY A 150
SER A 151
 None
 1.09A 3g2oB-1jkmA:
undetectable		 3g2oB-1jkmA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 ALA A 174
GLY A 170
LEU A 175
GLY A 244
SER A 243
 None
 0.89A 3g2oB-1jpuA:
2.9		 3g2oB-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 ALA A 170
GLY A 166
LEU A 171
GLY A 240
SER A 239
 None
None
None
None
CL  A 501 (-3.6A)
 0.95A 3g2oB-1kq3A:
undetectable		 3g2oB-1kq3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 ALA A 510
GLY A 496
ASP A 288
SER A 507
GLY A 493
 None
 0.92A 3g2oB-1l5jA:
2.6		 3g2oB-1l5jA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		5 GLU A  52
ALA A  53
GLY A  33
LEU A  17
GLY A  36
 None
 1.05A 3g2oB-1nwaA:
undetectable		 3g2oB-1nwaA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.95A 3g2oB-1p4aA:
3.1		 3g2oB-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF01144
(CoA_trans)
PF01144
(CoA_trans) 		5 GLY A 127
LEU A 130
LEU A 124
ASP A 104
GLY B 169
 None
 1.06A 3g2oB-1poiA:
undetectable		 3g2oB-1poiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qm9 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF13893
(RRM_5) 		5 ALA A 171
GLY A 145
LEU A 123
LEU A 175
SER A 167
 None
 1.08A 3g2oB-1qm9A:
undetectable		 3g2oB-1qm9A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyr HIGH LEVEL
KASUGAMYCIN
RESISTANCE PROTEIN

(Escherichia
coli) 		PF00398
(RrnaAD) 		5 GLU A  43
GLY A  47
LEU A  51
LEU A  67
ASP A  91
 None
 0.76A 3g2oB-1qyrA:
11.5		 3g2oB-1qyrA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 GLY A 637
LEU A 753
LEU A 761
SER A 631
GLY A 434
 None
 1.02A 3g2oB-1sb3A:
undetectable		 3g2oB-1sb3A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 ALA A  73
GLY A  83
LEU A  42
SER A  87
GLY A  23
 None
 1.10A 3g2oB-1scjA:
2.6		 3g2oB-1scjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 ALA A 233
GLY A 229
LEU A 234
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 0.93A 3g2oB-1ta9A:
undetectable		 3g2oB-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA B 171
GLY B 169
LEU B 157
GLY B 185
SER B 184
 None
 1.09A 3g2oB-1tqyB:
undetectable		 3g2oB-1tqyB:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ALA A 113
GLY A 109
LEU A 114
GLY A 143
GLU A 366
 None
 1.10A 3g2oB-1up4A:
3.8		 3g2oB-1up4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzn SAM-DEPENDENT
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 ALA A  49
GLY A  51
LEU A  69
LEU A  71
ASP A  96
 SAH  A1001 (-3.4A)
SAH  A1001 (-3.1A)
None
SAH  A1001 (-3.9A)
SAH  A1001 (-3.3A)
 0.35A 3g2oB-1wznA:
19.0		 3g2oB-1wznA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		6 ALA A  46
GLY A  48
LEU A  52
LEU A  68
ASP A  93
SER A 112
 None
 0.69A 3g2oB-1y8cA:
20.2		 3g2oB-1y8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		5 LEU A 189
ASP A 204
MET A 200
GLY A 297
SER A 296
 None
 1.10A 3g2oB-1zklA:
undetectable		 3g2oB-1zklA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		5 GLY C 213
LEU C 219
LEU C  83
GLY C 126
SER C 123
 None
 1.11A 3g2oB-2advC:
undetectable		 3g2oB-2advC:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLU A 798
ALA A 770
GLY A 672
LEU A 669
SER A 799
 None
 1.05A 3g2oB-2b3xA:
undetectable		 3g2oB-2b3xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 GLU A 798
ALA A 770
GLY A 672
LEU A 769
SER A 799
 None
 1.08A 3g2oB-2b3xA:
undetectable		 3g2oB-2b3xA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		5 LEU A 132
LEU A 118
LEU A 120
SER A 105
GLY A 101
 None
 1.05A 3g2oB-2eq5A:
undetectable		 3g2oB-2eq5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		5 ALA A 149
GLY A 153
LEU A 148
GLY A 195
SER A 194
 None
 0.89A 3g2oB-2f2bA:
undetectable		 3g2oB-2f2bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip2 PROBABLE
PHENAZINE-SPECIFIC
METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		6 GLY A 177
LEU A 181
LEU A 197
ASP A 225
MET A 226
SER A 240
 None
 0.88A 3g2oB-2ip2A:
19.6		 3g2oB-2ip2A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9l LACTADHERIN

(Mus musculus) 		PF00754
(F5_F8_type_C) 		5 GLU A 152
GLY A   6
LEU A  40
GLY A 155
GLU A   3
 None
 1.08A 3g2oB-2l9lA:
undetectable		 3g2oB-2l9lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 GLU A 130
ALA A 131
LEU A 134
GLY A 125
SER A  99
 None
 1.04A 3g2oB-2o7pA:
undetectable		 3g2oB-2o7pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.82A 3g2oB-2p8eA:
undetectable		 3g2oB-2p8eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 GLY A 556
LEU A 597
LEU A 534
SER A 560
GLY A 540
 None
 1.03A 3g2oB-2quaA:
undetectable		 3g2oB-2quaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3c TREPONEMA DENTICOLA
VARIABLE PROTEIN 1

(Treponema
denticola) 		PF03781
(FGE-sulfatase) 		5 GLY A 299
ASP A 255
SER A 238
GLY A 237
SER A 236
 None
 1.03A 3g2oB-2y3cA:
undetectable		 3g2oB-2y3cA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		5 GLY A 318
LEU A 322
LEU A 335
ASP A 346
MET A 347
 SAH  A 900 ( 3.7A)
None
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
 0.75A 3g2oB-2zfuA:
12.4		 3g2oB-2zfuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		5 GLY A 318
LEU A 335
ASP A 346
MET A 347
SER A 365
 SAH  A 900 ( 3.7A)
SAH  A 900 (-4.2A)
SAH  A 900 (-3.6A)
SAH  A 900 (-3.6A)
SAH  A 900 (-4.7A)
 0.95A 3g2oB-2zfuA:
12.4		 3g2oB-2zfuA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		5 ALA A  86
GLY A  88
LEU A  93
GLY A  77
SER A  78
 None
 0.98A 3g2oB-2zkiA:
undetectable		 3g2oB-2zkiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ALA A 238
GLY A 241
LEU A 292
LEU A 236
GLY A 285
 None
 0.85A 3g2oB-3b9yA:
undetectable		 3g2oB-3b9yA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  48
LEU A  66
LEU A  68
ASP A  89
MET A  90
SER A 108
 SAM  A 238 (-3.2A)
SAM  A 238 ( 3.7A)
None
SAM  A 238 (-3.9A)
SAM  A 238 (-3.0A)
SAM  A 238 (-4.4A)
SAM  A 238 (-3.2A)
 0.60A 3g2oB-3bxoA:
19.6		 3g2oB-3bxoA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		6 ALA A  46
LEU A  68
ASP A  89
MET A  90
SER A 107
SER A 108
 SAM  A 238 (-3.2A)
SAM  A 238 (-3.9A)
SAM  A 238 (-3.0A)
SAM  A 238 (-4.4A)
UPP  A 239 ( 4.3A)
SAM  A 238 (-3.2A)
 1.49A 3g2oB-3bxoA:
19.6		 3g2oB-3bxoA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		5 ALA A 158
GLY A 162
LEU A 164
GLY A 196
SER A 197
 None
 1.09A 3g2oB-3c8cA:
undetectable		 3g2oB-3c8cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 ALA A 205
GLY A 244
SER A  49
GLY A  47
SER A  48
 None
 1.08A 3g2oB-3cj1A:
undetectable		 3g2oB-3cj1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 GLY A 244
LEU A 250
SER A  49
GLY A  47
SER A  48
 None
 1.01A 3g2oB-3cj1A:
undetectable		 3g2oB-3cj1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 GLY A  42
LEU A  61
ASP A  86
MET A  87
SER A 105
 None
 0.56A 3g2oB-3d2lA:
20.6		 3g2oB-3d2lA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  52
LEU A  56
LEU A  71
ASP A 100
GLY A 118
 SAM  A 220 (-3.2A)
None
None
SAM  A 220 (-3.2A)
SAM  A 220 (-4.7A)
 0.64A 3g2oB-3dlcA:
17.0		 3g2oB-3dlcA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		12 GLU A  69
ALA A  71
GLY A  73
LEU A  77
LEU A  91
LEU A  93
ASP A 122
MET A 123
SER A 138
GLY A 140
SER A 141
GLU A 144
 SAH  A 500 (-4.2A)
SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-4.1A)
None
SAH  A 500 (-3.6A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.1A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.0A)
SAH  A 500 (-3.8A)
 0.49A 3g2oB-3g2pA:
32.3		 3g2oB-3g2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		6 GLU A  46
ALA A  49
LEU A  48
ASP A  31
SER A 231
SER A 232
 None
 1.31A 3g2oB-3hdyA:
2.1		 3g2oB-3hdyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 179
LEU A 183
LEU A 199
LEU A 201
SER A 242
 SAH  A 401 (-3.6A)
None
None
SAH  A 401 (-4.4A)
SAH  A 401 (-2.8A)
 0.85A 3g2oB-3i58A:
15.5		 3g2oB-3i58A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		5 ALA A 114
GLY A 110
LEU A 116
ASP A 119
GLY A  96
 None
 1.05A 3g2oB-3ipiA:
undetectable		 3g2oB-3ipiA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 GLY A  32
LEU A 179
LEU A  38
GLY A  81
SER A  80
 None
 1.02A 3g2oB-3lq1A:
undetectable		 3g2oB-3lq1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 209
LEU A 183
SER A 212
GLY A 215
GLU A 219
 None
MCA  A 486 ( 4.3A)
None
None
None
 1.04A 3g2oB-3nyqA:
undetectable		 3g2oB-3nyqA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		5 ALA A 286
GLY A 282
LEU A 102
LEU A 287
GLY A 251
 None
 0.96A 3g2oB-3orgA:
undetectable		 3g2oB-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pea ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 GLU A 242
GLY A 240
LEU A 133
SER A 256
GLY A 257
 None
 1.10A 3g2oB-3peaA:
undetectable		 3g2oB-3peaA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 ALA A 275
GLY A 273
LEU A 411
LEU A 279
GLY A 619
 FAD  A 669 (-3.3A)
FAD  A 669 (-3.3A)
None
None
FAD  A 669 (-3.0A)
 1.09A 3g2oB-3ps9A:
10.8		 3g2oB-3ps9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		7 ALA A  58
GLY A  60
LEU A  78
LEU A  80
ASP A 101
MET A 102
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-3.8A)
SAH  A 263 (-3.5A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.56A 3g2oB-3px2A:
19.9		 3g2oB-3px2A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjh 5C.C7 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  14
LEU B 112
SER B  87
GLY B  85
GLU B  83
 None
 1.03A 3g2oB-3qjhB:
undetectable		 3g2oB-3qjhB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qmw THIOESTERASE

(Streptomyces
coelicolor) 		PF00975
(Thioesterase) 		5 ALA A  41
GLY A  43
LEU A  66
ASP A 147
GLY A 109
 None
 1.10A 3g2oB-3qmwA:
undetectable		 3g2oB-3qmwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 ALA A 329
GLY A 331
LEU A 335
ASP A 388
GLY A 295
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-4.1A)
SAH  A 900 ( 3.7A)
 1.03A 3g2oB-3s1sA:
11.8		 3g2oB-3s1sA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 GLY A 175
LEU A 466
LEU A 171
GLY A 181
GLU A 182
 None
 0.95A 3g2oB-3t5oA:
undetectable		 3g2oB-3t5oA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		5 ALA A 236
GLY A 195
LEU A 192
ASP A  14
GLY A 241
 None
 1.09A 3g2oB-3tb5A:
undetectable		 3g2oB-3tb5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 ALA A 194
GLY A 190
LEU A 195
GLY A 266
SER A 265
 None
 0.92A 3g2oB-3uhjA:
undetectable		 3g2oB-3uhjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		5 GLU A 654
ALA A 652
GLY A 649
LEU A 493
GLY A 646
 None
 0.92A 3g2oB-3v8uA:
undetectable		 3g2oB-3v8uA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 GLY A 326
LEU A 321
LEU A 329
SER A  52
GLY A  65
 None
 1.08A 3g2oB-3va6A:
undetectable		 3g2oB-3va6A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 GLU A  37
ALA A  36
GLY A 223
LEU A  35
SER A  76
 None
 1.09A 3g2oB-3vcyA:
undetectable		 3g2oB-3vcyA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 ALA A 163
GLY A 173
LEU A 132
SER A 177
GLY A 113
 None
 1.06A 3g2oB-3whiA:
2.5		 3g2oB-3whiA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 ALA A 281
GLY A 279
SER A  74
GLY A  72
SER A  73
 ANP  A 700 (-4.5A)
ANP  A 700 (-3.7A)
ANP  A 700 (-2.7A)
ANP  A 700 (-3.6A)
ANP  A 700 (-2.8A)
 0.92A 3g2oB-4a5aA:
undetectable		 3g2oB-4a5aA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		5 ALA A 549
GLY A 551
LEU A 540
LEU A 429
GLY A 533
 None
 1.08A 3g2oB-4aahA:
undetectable		 3g2oB-4aahA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		5 ALA A  63
GLY A 180
LEU A 184
LEU A  62
GLY A 469
 FAD  A1493 (-3.3A)
None
None
None
FAD  A1493 ( 3.1A)
 1.10A 3g2oB-4at0A:
undetectable		 3g2oB-4at0A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ALA A 859
LEU A 892
LEU A 864
GLY A 854
GLU A 856
 None
 1.07A 3g2oB-4c3hA:
undetectable		 3g2oB-4c3hA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 188
GLY A 184
LEU A 189
SER A 143
GLY A 142
 None
 1.10A 3g2oB-4dyjA:
undetectable		 3g2oB-4dyjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 ALA L 372
GLY L 381
LEU L 376
GLY L 452
SER L 453
 None
 1.03A 3g2oB-4heaL:
undetectable		 3g2oB-4heaL:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 ALA A 653
GLY A 665
MET A 692
GLY A 657
SER A 658
 None
 1.08A 3g2oB-4k3cA:
undetectable		 3g2oB-4k3cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqb PROTEIN H03A11.1

(Caenorhabditis
elegans) 		PF06702
(Fam20C) 		5 ALA A 460
LEU A  90
ASP A 398
SER A  85
GLU A 456
 None
 1.05A 3g2oB-4kqbA:
undetectable		 3g2oB-4kqbA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 GLU A 175
ALA A 205
GLY A 251
LEU A 207
GLY A 248
 None
 1.06A 3g2oB-4lx4A:
undetectable		 3g2oB-4lx4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
None
None
None
NA  A1004 (-3.4A)
 0.94A 3g2oB-4mcaA:
undetectable		 3g2oB-4mcaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nec PUTATIVE
SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
lasaliensis) 		PF13649
(Methyltransf_25) 		5 GLY A  49
LEU A  69
ASP A  94
SER A 111
GLY A 112
 SAH  A 401 (-3.6A)
SAH  A 401 (-3.7A)
SAH  A 401 ( 3.6A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.6A)
 0.93A 3g2oB-4necA:
16.4		 3g2oB-4necA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 GLU A  84
GLY A  59
LEU A  65
SER A  90
SER A  93
 None
 0.97A 3g2oB-4q69A:
undetectable		 3g2oB-4q69A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.88A 3g2oB-4rafA:
undetectable		 3g2oB-4rafA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		5 ALA A  53
LEU A  27
SER A 273
GLY A  48
GLU A  50
 None
 1.04A 3g2oB-4rweA:
undetectable		 3g2oB-4rweA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 ALA A 375
GLY A 367
ASP A 240
GLY A 259
SER A 258
 None
 1.01A 3g2oB-4u4eA:
undetectable		 3g2oB-4u4eA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 ALA A 199
GLY A 195
LEU A 152
SER A 150
GLY A 222
 None
 1.09A 3g2oB-4z2aA:
undetectable		 3g2oB-4z2aA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmu DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF)
PF01590
(GAF) 		6 GLU A 155
ALA A 120
GLY A 123
ASP A  19
MET A  20
GLY A 127
 None
 1.50A 3g2oB-4zmuA:
undetectable		 3g2oB-4zmuA:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB

(Escherichia
coli) 		PF01458
(UPF0051) 		5 GLY A 322
LEU A 486
SER A 493
GLY A 351
SER A 350
 None
 0.91A 3g2oB-5awfA:
undetectable		 3g2oB-5awfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6h ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
pseudotuberculosis) 		PF00156
(Pribosyltran) 		5 ALA A 134
GLY A 166
LEU A 171
LEU A 162
GLY A 137
 AMP  A 501 (-3.4A)
None
None
None
AMP  A 501 (-4.0A)
 1.09A 3g2oB-5b6hA:
3.3		 3g2oB-5b6hA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		6 ALA A  53
GLY A  55
LEU A  75
ASP A  96
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.56A 3g2oB-5bszA:
19.1		 3g2oB-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		6 ALA A  53
LEU A  75
ASP A  96
MET A  97
GLY A 114
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.8A)
None
SAH  A 301 (-3.5A)
 0.93A 3g2oB-5bszA:
19.1		 3g2oB-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 LEU A  12
LEU A 215
SER A 148
GLY A 145
GLU A 146
 None
 1.08A 3g2oB-5eqiA:
undetectable		 3g2oB-5eqiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 6 GLY A 341
LEU A 351
MET A 313
SER A 405
GLY A 363
SER A 362
 None
 1.49A 3g2oB-5h3kA:
undetectable		 3g2oB-5h3kA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00583
(Acetyltransf_1) 		5 GLY B  80
LEU B 119
LEU B 159
SER B  42
SER B 104
 None
 1.04A 3g2oB-5nnpB:
2.6		 3g2oB-5nnpB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 5 ALA A 642
LEU A 662
LEU A 643
LEU A 640
GLY A 518
 None
 1.03A 3g2oB-5nprA:
3.6		 3g2oB-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovt BPH

(Thiobacillus
denitrificans) 		no annotation 5 ALA A 170
GLY A 166
LEU A 145
SER A 141
GLY A 138
 None
None
None
None
PO4  A 301 ( 3.7A)
 1.04A 3g2oB-5ovtA:
undetectable		 3g2oB-5ovtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suh MSM0271 PROTEIN

(Mycolicibacterium
smegmatis) 		no annotation 5 LEU A  77
LEU A  48
LEU A  17
GLY A  84
GLU A  51
 None
 0.99A 3g2oB-5suhA:
undetectable		 3g2oB-5suhA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuk TETRACYCLINE
DESTRUCTASE TET(51)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		5 ALA A  15
GLY A  13
LEU A 108
SER A 302
GLY A 301
 FAD  A 402 (-3.5A)
FAD  A 402 (-3.2A)
None
FAD  A 402 (-3.4A)
FAD  A 402 (-3.0A)
 1.05A 3g2oB-5tukA:
undetectable		 3g2oB-5tukA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdn GLUTATHIONE
OXIDOREDUCTASE

(Yersinia pestis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 324
GLY A 312
LEU A 146
LEU A 320
GLY A  23
 FAD  A 502 ( 3.8A)
FAD  A 502 (-3.3A)
None
FAD  A 502 (-3.7A)
FAD  A 502 (-3.3A)
 1.10A 3g2oB-5vdnA:
3.2		 3g2oB-5vdnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF06833
(MdcE)
PF01039
(Carboxyl_trans) 		5 ALA B 166
GLY B 168
LEU A 115
LEU B 114
GLY B 161
 None
 1.08A 3g2oB-5vipB:
undetectable		 3g2oB-5vipB:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7a ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT

(Oryctolagus
cuniculus) 		no annotation 5 GLY B 452
LEU B 447
ASP B 527
SER B 464
GLY B 461
 None
FTT  B 609 (-4.3A)
FTT  B 609 ( 4.8A)
None
None
 0.83A 3g2oB-5w7aB:
2.2		 3g2oB-5w7aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		5 ALA A 417
GLY A 419
LEU A 413
GLY A 424
SER A 423
 None
 1.09A 3g2oB-5wu3A:
undetectable		 3g2oB-5wu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 ALA A 278
LEU A 275
SER A  27
GLY A 285
SER A  28
 None
 1.06A 3g2oB-5xa2A:
3.2		 3g2oB-5xa2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
 0.97A 3g2oB-5xn8A:
undetectable		 3g2oB-5xn8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.89A 3g2oB-6b67A:
undetectable		 3g2oB-6b67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 5 ALA A 267
GLY A 268
LEU A 242
LEU A 265
GLY A 235
 None
 1.08A 3g2oB-6f9gA:
undetectable		 3g2oB-6f9gA:
undetectable