SIMILAR PATTERNS OF AMINO ACIDS FOR 3G2O_A_SAMA500

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLU A 396
GLY A 444
SER A 399
GLY A 335
GLU A 334
 None
 0.96A 3g2oA-1b41A:
undetectable		 3g2oA-1b41A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dp2 RHODANESE

(Bos taurus) 		PF00581
(Rhodanese) 		5 ALA A 245
LEU A 161
LEU A 243
SER A 207
GLY A 250
 None
 1.01A 3g2oA-1dp2A:
undetectable		 3g2oA-1dp2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 342
LEU A 409
LEU A 413
SER A 348
SER A 301
 None
 1.06A 3g2oA-1gz7A:
undetectable		 3g2oA-1gz7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 103
LEU A  80
LEU A 109
SER A 138
GLY A  98
 None
 0.93A 3g2oA-1inlA:
13.0		 3g2oA-1inlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 ALA A 174
GLY A 170
LEU A 175
GLY A 244
SER A 243
 None
 0.88A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		5 ALA A 174
LEU A 175
SER A 169
GLY A 244
SER A 243
 None
 1.02A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jpu GLYCEROL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00465
(Fe-ADH) 		6 GLU A 180
LEU A 252
LEU A 175
SER A 169
GLY A 244
SER A 243
 None
 1.29A 3g2oA-1jpuA:
undetectable		 3g2oA-1jpuA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		6 ALA A  19
GLY A 374
LEU A 396
LEU A 392
SER A 391
GLY A  15
 FAD  A 800 (-3.4A)
FAD  A 800 (-3.5A)
None
FAD  A 800 (-3.4A)
FAD  A 800 (-2.6A)
FAD  A 800 (-3.1A)
 1.35A 3g2oA-1knrA:
2.9		 3g2oA-1knrA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  74
LEU A  93
LEU A  95
SER A  96
GLY A 137
 SAH  A1900 (-3.2A)
SAH  A1900 ( 4.9A)
SAH  A1900 (-4.4A)
None
CO3  A1902 (-3.1A)
 1.06A 3g2oA-1kphA:
15.7		 3g2oA-1kphA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		5 ALA A 170
GLY A 166
LEU A 171
GLY A 240
SER A 239
 None
None
None
None
CL  A 501 (-3.6A)
 0.94A 3g2oA-1kq3A:
undetectable		 3g2oA-1kq3A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1e MYCOLIC ACID
SYNTHASE

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 GLY A  74
LEU A  93
LEU A  95
SER A  96
GLY A 137
 SAH  A 900 (-3.4A)
None
SAH  A 900 (-4.1A)
None
CO3  A 903 ( 3.5A)
 1.08A 3g2oA-1l1eA:
16.2		 3g2oA-1l1eA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 GLY A 485
LEU A 481
LEU A 535
SER A 213
GLY A 215
 None
 1.04A 3g2oA-1mt5A:
undetectable		 3g2oA-1mt5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 GLU A 209
GLY A 373
SER A 392
GLY A 104
GLU A 105
 None
 1.10A 3g2oA-1nl3A:
3.8		 3g2oA-1nl3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nwa PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA

(Mycobacterium
tuberculosis) 		PF01625
(PMSR) 		5 GLU A  52
ALA A  53
GLY A  33
LEU A  17
GLY A  36
 None
 1.02A 3g2oA-1nwaA:
undetectable		 3g2oA-1nwaA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 GLU A 234
ALA A 235
GLY A 237
LEU A 252
GLY A 209
 None
None
None
None
PCP  A 604 (-3.4A)
 0.96A 3g2oA-1p4aA:
2.4		 3g2oA-1p4aA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		5 GLU A 146
ALA A 147
GLY A 145
LEU A 115
SER A 116
 None
 1.03A 3g2oA-1r6eA:
undetectable		 3g2oA-1r6eA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 ALA A 233
GLY A 229
LEU A 234
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 0.93A 3g2oA-1ta9A:
undetectable		 3g2oA-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta9 GLYCEROL
DEHYDROGENASE

(Schizosaccharomyces
pombe) 		PF00465
(Fe-ADH) 		5 ALA A 233
LEU A 234
SER A 228
GLY A 303
SER A 302
 None
None
None
None
K  A1503 (-3.6A)
 1.01A 3g2oA-1ta9A:
undetectable		 3g2oA-1ta9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA B 171
GLY B 169
LEU B 157
GLY B 185
SER B 184
 None
 1.09A 3g2oA-1tqyB:
undetectable		 3g2oA-1tqyB:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		6 ALA A  46
GLY A  48
LEU A  52
LEU A  68
SER A  69
SER A 112
 None
 0.71A 3g2oA-1y8cA:
19.4		 3g2oA-1y8cA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		5 ALA A 138
GLY A  93
SER A 102
GLY A 120
GLU A 119
 None
 0.96A 3g2oA-1zovA:
3.0		 3g2oA-1zovA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ALA A 558
GLY A 560
LEU A 549
LEU A 436
GLY A 542
 None
 1.02A 3g2oA-2d0vA:
undetectable		 3g2oA-2d0vA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 GLY A 410
SER A 403
SER A 420
GLY A 416
SER A 417
 None
 1.07A 3g2oA-2dh3A:
undetectable		 3g2oA-2dh3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2b AQUAPORIN AQPM

(Methanothermobacter
marburgensis) 		PF00230
(MIP) 		5 ALA A 149
GLY A 153
LEU A 148
GLY A 195
SER A 194
 None
 0.88A 3g2oA-2f2bA:
undetectable		 3g2oA-2f2bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iy9 SUBA

(Escherichia
coli) 		PF00082
(Peptidase_S8) 		5 GLY A  90
SER A 114
SER A 272
GLY A 151
SER A 150
 None
 1.02A 3g2oA-2iy9A:
2.5		 3g2oA-2iy9A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 ALA A 334
GLY A 332
LEU A 196
SER A 311
GLY A 307
 None
None
None
None
UDP  A1401 ( 3.9A)
 1.01A 3g2oA-2iyfA:
undetectable		 3g2oA-2iyfA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9l LACTADHERIN

(Mus musculus) 		PF00754
(F5_F8_type_C) 		5 GLU A 152
GLY A   6
LEU A  40
GLY A 155
GLU A   3
 None
 1.05A 3g2oA-2l9lA:
undetectable		 3g2oA-2l9lA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 GLU A 130
ALA A 131
LEU A 134
GLY A 125
SER A  99
 None
 1.06A 3g2oA-2o7pA:
undetectable		 3g2oA-2o7pA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8e PPM1B BETA ISOFORM
VARIANT 6

(Homo sapiens) 		PF00481
(PP2C) 		5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 0.95A 3g2oA-2p8eA:
undetectable		 3g2oA-2p8eA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		5 ALA A 183
GLY A 108
LEU A 185
LEU A 181
SER A 178
 None
None
None
None
GG9  A 501 ( 4.8A)
 1.10A 3g2oA-2pqdA:
undetectable		 3g2oA-2pqdA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 GLY A 556
LEU A 597
LEU A 534
SER A 560
GLY A 540
 None
 1.04A 3g2oA-2quaA:
undetectable		 3g2oA-2quaA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyv XAA-HIS DIPEPTIDASE

(Histophilus
somni) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ALA A 186
LEU A 347
SER A 348
SER A 394
GLY A 395
 None
None
None
SO4  A 508 (-4.7A)
SO4  A 508 (-3.5A)
 1.09A 3g2oA-2qyvA:
undetectable		 3g2oA-2qyvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum) 		PF02458
(Transferase) 		5 LEU A  66
LEU A  20
SER A  13
GLY A  15
SER A  16
 None
 1.07A 3g2oA-2xr7A:
undetectable		 3g2oA-2xr7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyb LACCASE

(Trametes
cinnabarina) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A  58
LEU A 497
SER A 495
GLY A  90
SER A  89
 None
 1.09A 3g2oA-2xybA:
undetectable		 3g2oA-2xybA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		5 ALA A  86
GLY A  88
LEU A  93
GLY A  77
SER A  78
 None
 1.03A 3g2oA-2zkiA:
undetectable		 3g2oA-2zkiA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 GLU A  89
ALA A  90
GLY A  71
LEU A  93
GLY A  50
 None
 1.10A 3g2oA-2zncA:
undetectable		 3g2oA-2zncA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 596
LEU A 566
LEU A 548
SER A 602
GLY A 601
 None
 1.07A 3g2oA-3b2dA:
undetectable		 3g2oA-3b2dA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 ALA A 238
GLY A 241
LEU A 292
LEU A 236
GLY A 285
 None
 0.81A 3g2oA-3b9yA:
undetectable		 3g2oA-3b9yA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhn THIJ/PFPI DOMAIN
PROTEIN

(Shewanella
loihica) 		PF01965
(DJ-1_PfpI) 		5 ALA A 148
GLY A 150
LEU A 139
SER A 103
GLY A 102
 None
 1.10A 3g2oA-3bhnA:
undetectable		 3g2oA-3bhnA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxo N,N-DIMETHYLTRANSFER
ASE

(Streptomyces
venezuelae) 		PF13649
(Methyltransf_25) 		7 ALA A  46
GLY A  48
LEU A  66
LEU A  68
SER A  69
MET A  90
SER A 108
 SAM  A 238 (-3.2A)
SAM  A 238 ( 3.7A)
None
SAM  A 238 (-3.9A)
SAM  A 238 (-4.6A)
SAM  A 238 (-4.4A)
SAM  A 238 (-3.2A)
 0.61A 3g2oA-3bxoA:
19.0		 3g2oA-3bxoA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8c METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		5 ALA A 158
GLY A 162
LEU A 164
GLY A 196
SER A 197
 None
 1.10A 3g2oA-3c8cA:
undetectable		 3g2oA-3c8cA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 GLY A 244
LEU A 250
SER A  49
GLY A  47
SER A  48
 None
 1.05A 3g2oA-3cj1A:
undetectable		 3g2oA-3cj1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 GLY A  42
LEU A  61
SER A  62
MET A  87
SER A 105
 None
 0.73A 3g2oA-3d2lA:
20.0		 3g2oA-3d2lA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcy REGULATOR PROTEIN

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 GLY A 199
LEU A  87
LEU A 205
SER A 204
GLY A 234
 PO4  A 271 (-3.9A)
None
None
None
None
 1.10A 3g2oA-3dcyA:
undetectable		 3g2oA-3dcyA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlc PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE

(Methanococcus
maripaludis) 		PF08241
(Methyltransf_11) 		5 GLY A  52
LEU A  56
LEU A  71
SER A  74
GLY A 118
 SAM  A 220 (-3.2A)
None
None
GOL  A 222 ( 3.2A)
SAM  A 220 (-4.7A)
 0.63A 3g2oA-3dlcA:
16.1		 3g2oA-3dlcA:
19.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		12 GLU A  69
ALA A  71
GLY A  73
LEU A  77
LEU A  91
LEU A  93
SER A  94
MET A 123
SER A 138
GLY A 140
SER A 141
GLU A 144
 SAH  A 500 (-4.2A)
SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
SAH  A 500 (-4.1A)
None
SAH  A 500 (-3.6A)
SAH  A 500 ( 4.9A)
SAH  A 500 (-4.3A)
SAH  A 500 (-3.1A)
SAH  A 500 ( 4.6A)
SAH  A 500 (-3.0A)
SAH  A 500 (-3.8A)
 0.31A 3g2oA-3g2pA:
35.3		 3g2oA-3g2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i58 O-METHYLTRANSFERASE

(Streptomyces
carzinostaticus) 		PF00891
(Methyltransf_2) 		5 GLY A 179
LEU A 183
LEU A 199
LEU A 201
SER A 242
 SAH  A 401 (-3.6A)
None
None
SAH  A 401 (-4.4A)
SAH  A 401 (-2.8A)
 0.94A 3g2oA-3i58A:
15.1		 3g2oA-3i58A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 3,
CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		PF01789
(PsbP)
PF05757
(PsbQ) 		5 GLU P  78
LEU Q  13
SER Q  14
SER P 116
GLU P 115
 None
 1.00A 3g2oA-3jcuP:
undetectable		 3g2oA-3jcuP:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 GLY A  32
LEU A 179
LEU A  38
GLY A  81
SER A  80
 None
 1.03A 3g2oA-3lq1A:
undetectable		 3g2oA-3lq1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		6 ALA A 367
GLY A 370
LEU A 375
LEU A 364
SER A  62
GLY A 323
 None
 1.43A 3g2oA-3lscA:
undetectable		 3g2oA-3lscA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 5 GLY G 227
LEU G 234
LEU G 175
SER G 155
GLY G 157
 None
 0.89A 3g2oA-3mmpG:
undetectable		 3g2oA-3mmpG:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		5 ALA A 286
GLY A 103
LEU A 287
SER A 254
GLY A 251
 None
 1.06A 3g2oA-3orgA:
undetectable		 3g2oA-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3org CMCLC

(Cyanidioschyzon
merolae) 		PF00654
(Voltage_CLC) 		5 ALA A 286
GLY A 282
LEU A 102
LEU A 287
GLY A 251
 None
 1.00A 3g2oA-3orgA:
undetectable		 3g2oA-3orgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 ALA A 275
GLY A 273
LEU A 411
LEU A 279
GLY A 619
 FAD  A 669 (-3.3A)
FAD  A 669 (-3.3A)
None
None
FAD  A 669 (-3.0A)
 1.03A 3g2oA-3ps9A:
10.1		 3g2oA-3ps9A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		7 ALA A  58
GLY A  60
LEU A  78
LEU A  80
SER A  81
MET A 102
SER A 120
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-3.8A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.56A 3g2oA-3px2A:
18.5		 3g2oA-3px2A:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjh 5C.C7 BETA CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLY B  14
LEU B 112
SER B  87
GLY B  85
GLU B  83
 None
 1.05A 3g2oA-3qjhB:
undetectable		 3g2oA-3qjhB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF01168
(Ala_racemase_N) 		5 LEU A 111
LEU A 122
SER A 121
GLY A 161
GLU A 160
 None
 1.06A 3g2oA-3r79A:
undetectable		 3g2oA-3r79A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5o COMPLEMENT COMPONENT
C6

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00084
(Sushi)
PF00090
(TSP_1)
PF01823
(MACPF) 		5 GLY A 175
LEU A 466
LEU A 171
GLY A 181
GLU A 182
 None
 0.94A 3g2oA-3t5oA:
undetectable		 3g2oA-3t5oA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		5 ALA A 177
GLY A 103
LEU A 179
LEU A 175
SER A 172
 None
None
None
None
PO4  A 441 (-2.8A)
 1.09A 3g2oA-3tr1A:
undetectable		 3g2oA-3tr1A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ALA A 507
GLY A 549
LEU A 458
SER A 579
SER A 492
 None
 0.96A 3g2oA-3u1kA:
undetectable		 3g2oA-3u1kA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 ALA A 194
GLY A 190
LEU A 195
GLY A 266
SER A 265
 None
 0.92A 3g2oA-3uhjA:
undetectable		 3g2oA-3uhjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vc1 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
coelicolor) 		PF08241
(Methyltransf_11) 		5 GLY A 107
LEU A 128
SER A 129
MET A 156
SER A 174
 SAH  A 302 (-3.3A)
SAH  A 302 (-4.1A)
None
SAH  A 302 (-3.9A)
SAH  A 302 (-4.5A)
 0.89A 3g2oA-3vc1A:
16.0		 3g2oA-3vc1A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		5 GLY A 113
LEU A 268
LEU A  83
SER A 168
GLU A 343
 SQS  A 401 ( 4.2A)
SQS  A 401 (-4.4A)
None
SQS  A 401 (-3.1A)
None
 1.03A 3g2oA-3vzbA:
undetectable		 3g2oA-3vzbA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 ALA A 281
GLY A 279
SER A  74
GLY A  72
SER A  73
 ANP  A 700 (-4.5A)
ANP  A 700 (-3.7A)
ANP  A 700 (-2.7A)
ANP  A 700 (-3.6A)
ANP  A 700 (-2.8A)
 1.01A 3g2oA-4a5aA:
undetectable		 3g2oA-4a5aA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		5 ALA A 549
GLY A 551
LEU A 540
LEU A 429
GLY A 533
 None
 1.06A 3g2oA-4aahA:
undetectable		 3g2oA-4aahA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eru YCIF BACTERIAL
STRESS RESPONSE
PROTEIN

(Salmonella
enterica) 		PF05974
(DUF892) 		5 ALA A  85
LEU A 102
SER A  91
GLY A  80
GLU A  83
 None
 1.07A 3g2oA-4eruA:
undetectable		 3g2oA-4eruA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f85 GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E

(Streptomyces
lasaliensis) 		PF02353
(CMAS) 		5 GLY A 115
LEU A 136
SER A 137
MET A 164
SER A 182
 None
 0.93A 3g2oA-4f85A:
16.7		 3g2oA-4f85A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		5 GLY A 102
LEU A 117
MET A  60
SER A  29
GLY A  32
 None
 1.00A 3g2oA-4gpgA:
undetectable		 3g2oA-4gpgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 ALA L 372
GLY L 381
LEU L 376
GLY L 452
SER L 453
 None
 1.08A 3g2oA-4heaL:
undetectable		 3g2oA-4heaL:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 11
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00420
(Oxidored_q2)
PF00361
(Proton_antipo_M) 		5 ALA N 120
LEU N 130
LEU N 121
SER N 115
GLY K  73
 None
 1.06A 3g2oA-4heaN:
undetectable		 3g2oA-4heaN:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jci PROLINE RACEMASE

(Chromohalobacter
salexigens) 		PF05544
(Pro_racemase) 		5 ALA A  12
GLY A  13
SER A 263
GLY A 266
SER A 267
 None
 0.90A 3g2oA-4jciA:
undetectable		 3g2oA-4jciA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 6 GLU D  22
GLY D  12
SER D 349
SER D  23
GLY D  18
SER D  24
 None
 1.20A 3g2oA-4jrmD:
undetectable		 3g2oA-4jrmD:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 162
LEU A 153
SER A 180
SER A 244
GLY A 245
 None
 1.09A 3g2oA-4jxkA:
6.0		 3g2oA-4jxkA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3c OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

([Haemophilus]
ducreyi) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 ALA A 653
GLY A 665
MET A 692
GLY A 657
SER A 658
 None
 1.07A 3g2oA-4k3cA:
undetectable		 3g2oA-4k3cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx4 ENDOGLUCANASE(ENDO-1
,4-BETA-GLUCANASE)PR
OTEIN

(Pseudomonas
stutzeri) 		PF00150
(Cellulase) 		5 GLU A 175
ALA A 205
GLY A 251
LEU A 207
GLY A 248
 None
 1.08A 3g2oA-4lx4A:
undetectable		 3g2oA-4lx4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mca GLYCEROL
DEHYDROGENASE

(Serratia
plymuthica) 		PF00465
(Fe-ADH) 		5 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
None
None
None
NA  A1004 (-3.4A)
 0.93A 3g2oA-4mcaA:
undetectable		 3g2oA-4mcaA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLU A 858
LEU A 865
LEU A 884
GLY A 589
SER A 590
 None
 1.10A 3g2oA-4mz0A:
undetectable		 3g2oA-4mz0A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 GLY A  60
LEU A  66
LEU A 138
SER A 254
GLY A 263
 None
 1.07A 3g2oA-4q2eA:
undetectable		 3g2oA-4q2eA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 GLU A  84
GLY A  59
LEU A  65
SER A  90
SER A  93
 None
 1.03A 3g2oA-4q69A:
undetectable		 3g2oA-4q69A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLU A 193
ALA A 192
GLY A 107
SER A 145
GLY A 347
 None
 1.05A 3g2oA-4qavA:
undetectable		 3g2oA-4qavA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 1.01A 3g2oA-4rafA:
undetectable		 3g2oA-4rafA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yv2 SPERMIDINE SYNTHASE,
PUTATIVE

(Trypanosoma
cruzi) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 100
LEU A  77
LEU A 106
SER A 135
GLY A  95
 None
None
None
None
S4M  A 301 (-3.5A)
 1.02A 3g2oA-4yv2A:
12.8		 3g2oA-4yv2A:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLU C  42
GLY C  38
LEU C  36
SER C  43
GLY C 103
 None
 1.06A 3g2oA-4z42C:
undetectable		 3g2oA-4z42C:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awf FES CLUSTER ASSEMBLY
PROTEIN SUFB

(Escherichia
coli) 		PF01458
(UPF0051) 		5 GLY A 322
LEU A 486
SER A 493
GLY A 351
SER A 350
 None
 0.83A 3g2oA-5awfA:
undetectable		 3g2oA-5awfA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 GLY A 572
LEU A 568
MET A 555
GLY A 579
GLU A 631
 None
 1.09A 3g2oA-5bs5A:
undetectable		 3g2oA-5bs5A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		6 ALA A  53
GLY A  55
LEU A  75
SER A  76
MET A  97
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.5A)
 0.56A 3g2oA-5bszA:
18.4		 3g2oA-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		6 ALA A  53
LEU A  75
SER A  76
MET A  97
GLY A 114
SER A 115
 SAH  A 301 (-3.3A)
SAH  A 301 (-3.9A)
SAH  A 301 (-4.6A)
SAH  A 301 (-3.8A)
None
SAH  A 301 (-3.5A)
 0.99A 3g2oA-5bszA:
18.4		 3g2oA-5bszA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU B 352
LEU B 333
SER B 334
SER B 318
GLY B 316
 None
 0.99A 3g2oA-5gqrB:
undetectable		 3g2oA-5gqrB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5npr UDP-N-ACETYLGLUCOSAM
INE--PEPTIDE
N-ACETYLGLUCOSAMINYL
TRANSFERASE 110 KDA
SUBUNIT

(Homo sapiens) 		no annotation 5 ALA A 642
LEU A 662
LEU A 643
LEU A 640
GLY A 518
 None
 1.01A 3g2oA-5nprA:
3.3		 3g2oA-5nprA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 GLU T  98
LEU T  56
LEU T 100
LEU T 104
SER T 105
 None
 1.07A 3g2oA-5ojsT:
undetectable		 3g2oA-5ojsT:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE
MDCD

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF06833
(MdcE)
PF01039
(Carboxyl_trans) 		5 ALA B 166
GLY B 168
LEU A 115
LEU B 114
GLY B 161
 None
 1.05A 3g2oA-5vipB:
undetectable		 3g2oA-5vipB:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		5 GLY A 348
LEU A 291
LEU A 257
SER A 256
GLY A 386
 None
 0.98A 3g2oA-5vj1A:
2.0		 3g2oA-5vj1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 5 ALA A 148
GLY A 150
LEU A 211
SER A 236
SER A 220
 PHB  A 602 (-3.8A)
None
None
PHB  A 602 ( 3.9A)
PHB  A 602 ( 4.6A)
 0.98A 3g2oA-5w1eA:
undetectable		 3g2oA-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5way TRANSCRIPTIONAL
ACTIVATOR

(Streptococcus
pneumoniae) 		PF05043
(Mga)
PF08270
(PRD_Mga)
PF08280
(HTH_Mga) 		5 GLU A 182
LEU A 181
LEU A 177
SER A 174
GLY A 240
 None
 0.98A 3g2oA-5wayA:
undetectable		 3g2oA-5wayA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu3 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF03828
(PAP_assoc) 		5 ALA A 417
GLY A 419
LEU A 413
GLY A 424
SER A 423
 None
 1.08A 3g2oA-5wu3A:
undetectable		 3g2oA-5wu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8g 2-SUCCINYLBENZOATE--
COA LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		6 ALA A  57
LEU A 149
LEU A  59
SER A  99
GLY A 100
SER A 101
 None
 1.33A 3g2oA-5x8gA:
undetectable		 3g2oA-5x8gA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 5 ALA A 170
LEU A 168
SER A 145
GLY A 189
GLU A 172
 None
 0.96A 3g2oA-5x9wA:
undetectable		 3g2oA-5x9wA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 ALA A 172
GLY A 168
LEU A 173
GLY A 242
SER A 241
 None
 0.96A 3g2oA-5xn8A:
undetectable		 3g2oA-5xn8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 5 GLY A  17
LEU A  22
LEU A  26
SER A  54
GLY A  45
 None
 1.00A 3g2oA-6b67A:
undetectable		 3g2oA-6b67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU

(Pseudomonas
putida) 		no annotation 5 ALA A 267
GLY A 268
LEU A 242
LEU A 265
GLY A 235
 None
 1.05A 3g2oA-6f9gA:
undetectable		 3g2oA-6f9gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 ARG A  80
GLU A 144
ASP A 148
 None
IRP  A 300 (-2.8A)
IRP  A 300 (-3.8A)
 0.89A 3g2oA-1cjbA:
undetectable		 3g2oA-1cjbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ARG A 338
GLU A 359
ASP A 279
 GLV  A2000 (-3.6A)
None
None
 0.87A 3g2oA-1d8cA:
0.2		 3g2oA-1d8cA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eov ASPARTYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 112
GLU A 163
ASP A 238
 None
 0.80A 3g2oA-1eovA:
0.2		 3g2oA-1eovA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f4h BETA-GALACTOSIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		3 ARG A 352
GLU A 650
ASP A 671
 None
 0.84A 3g2oA-1f4hA:
undetectable		 3g2oA-1f4hA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ARG A 425
GLU A 135
ASP A 130
 None
 0.81A 3g2oA-1g7cA:
undetectable		 3g2oA-1g7cA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG B 968
GLU B 777
ASP B 782
 None
 0.68A 3g2oA-1gl9B:
5.0		 3g2oA-1gl9B:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jke D-TYR-TRNATYR
DEACYLASE

(Escherichia
coli) 		PF02580
(Tyr_Deacylase) 		3 ARG A  48
GLU A  34
ASP A  84
 None
 0.65A 3g2oA-1jkeA:
undetectable		 3g2oA-1jkeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8a PROTEIN TYROSINE
PHOSPHATASE

(Tritrichomonas
suis) 		PF01451
(LMWPc) 		3 ARG A  68
GLU A  22
ASP A  31
 None
 0.92A 3g2oA-1p8aA:
undetectable		 3g2oA-1p8aA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 196
GLU A 512
ASP A 452
 None
 0.79A 3g2oA-1po0A:
undetectable		 3g2oA-1po0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus;
Bos taurus) 		PF04045
(P34-Arc)
PF05856
(ARPC4) 		3 ARG F 156
GLU F 145
ASP D 272
 None
 0.62A 3g2oA-1u2vF:
undetectable		 3g2oA-1u2vF:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		3 ARG A 144
GLU A 151
ASP A 166
 None
 0.89A 3g2oA-1umfA:
undetectable		 3g2oA-1umfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un9 DIHYDROXYACETONE
KINASE

(Citrobacter
freundii) 		PF02733
(Dak1)
PF02734
(Dak2) 		3 ARG A  39
GLU A  62
ASP A 299
 None
 0.80A 3g2oA-1un9A:
undetectable		 3g2oA-1un9A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		3 ARG A  75
GLU A 109
ASP A 102
 None
 0.81A 3g2oA-1wwsA:
undetectable		 3g2oA-1wwsA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y79 PEPTIDYL-DIPEPTIDASE
DCP

(Escherichia
coli) 		PF01432
(Peptidase_M3) 		3 ARG 1 248
GLU 1 576
ASP 1 586
 None
 0.74A 3g2oA-1y791:
undetectable		 3g2oA-1y791:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		3 ARG A 210
GLU A 222
ASP A 228
 PO4  A 249 (-4.5A)
None
None
 0.75A 3g2oA-2avnA:
15.9		 3g2oA-2avnA:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 ARG A 339
GLU A 360
ASP A 280
 MLT  A 900 (-2.9A)
None
None
 0.88A 3g2oA-2gq3A:
undetectable		 3g2oA-2gq3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		3 ARG A 154
GLU A 321
ASP A 161
 None
 0.60A 3g2oA-2h0aA:
2.1		 3g2oA-2h0aA:
26.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 ARG A  88
GLU A  60
ASP A  13
 None
 0.90A 3g2oA-2id5A:
undetectable		 3g2oA-2id5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivw PILP PILOT PROTEIN

(Neisseria
meningitidis) 		PF04351
(PilP) 		3 ARG A  96
GLU A 145
ASP A 149
 None
 0.80A 3g2oA-2ivwA:
undetectable		 3g2oA-2ivwA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6l DNAJ HOMOLOG
SUBFAMILY C MEMBER
24

(Homo sapiens) 		PF00226
(DnaJ)
PF05207
(zf-CSL) 		3 ARG A  76
GLU A 127
ASP A 108
 None
 0.94A 3g2oA-2l6lA:
undetectable		 3g2oA-2l6lA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7f PITUITARY HOMEOBOX 2

(Homo sapiens) 		PF00046
(Homeobox) 		3 ARG P  22
GLU P  17
ASP P  66
 None
 0.75A 3g2oA-2l7fP:
undetectable		 3g2oA-2l7fP:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm9 BLO T 21 ALLERGEN

(Blomia
tropicalis) 		PF11642
(Blo-t-5) 		3 ARG A 108
GLU A 113
ASP A  48
 None
 0.89A 3g2oA-2lm9A:
undetectable		 3g2oA-2lm9A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		3 ARG A 156
GLU A 148
ASP A 112
 None
 0.94A 3g2oA-2oodA:
undetectable		 3g2oA-2oodA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		3 ARG A  39
GLU B 571
ASP A 353
 None
 0.88A 3g2oA-2pjrA:
3.0		 3g2oA-2pjrA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 ARG A  16
GLU A 347
ASP A 308
 None
 0.94A 3g2oA-2qtkA:
undetectable		 3g2oA-2qtkA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		3 ARG A 337
GLU A 383
ASP A 466
 None
 0.94A 3g2oA-2rdyA:
undetectable		 3g2oA-2rdyA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vm6 BCL-2-RELATED
PROTEIN A1

(Homo sapiens) 		PF00452
(Bcl-2) 		3 ARG A  68
GLU A  96
ASP A  15
 None
 0.83A 3g2oA-2vm6A:
undetectable		 3g2oA-2vm6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ARG A 756
GLU A 761
ASP A 815
 None
GOL  A1924 (-3.8A)
None
 0.93A 3g2oA-2wanA:
undetectable		 3g2oA-2wanA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CP43
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		3 ARG C 390
GLU C 300
ASP C 187
 None
 0.85A 3g2oA-3a0hC:
undetectable		 3g2oA-3a0hC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		3 ARG A 214
GLU A 239
ASP A 257
 None
 0.86A 3g2oA-3ciaA:
undetectable		 3g2oA-3ciaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		3 ARG A 233
GLU A 209
ASP A 527
 None
 0.81A 3g2oA-3ddnA:
6.7		 3g2oA-3ddnA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 ARG A 293
GLU A 242
ASP A 260
 CL  A 501 (-4.3A)
None
None
 0.91A 3g2oA-3eckA:
undetectable		 3g2oA-3eckA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		3 ARG A 347
GLU A 252
ASP A 170
 None
 0.86A 3g2oA-3fgbA:
undetectable		 3g2oA-3fgbA:
22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		3 ARG A  76
GLU A  92
ASP A 122
 SAH  A 500 (-3.4A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.6A)
 0.12A 3g2oA-3g2pA:
35.3		 3g2oA-3g2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdc MULTICOPPER OXIDASE

(Arthrobacter
sp. FB24) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A  82
GLU A 175
ASP A 173
 None
 0.90A 3g2oA-3gdcA:
undetectable		 3g2oA-3gdcA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkb PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
avermitilis) 		PF00378
(ECH_1) 		3 ARG A  71
GLU A 265
ASP A 267
 None
 0.77A 3g2oA-3gkbA:
undetectable		 3g2oA-3gkbA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ARG B 379
GLU B 683
ASP B 678
 None
 0.78A 3g2oA-3h0gB:
undetectable		 3g2oA-3h0gB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		3 ARG A 322
GLU A  87
ASP A  89
 None
 0.76A 3g2oA-3h84A:
undetectable		 3g2oA-3h84A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ham AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Enterococcus
faecium) 		PF01636
(APH) 		3 ARG A  50
GLU A  56
ASP A 192
 None
None
LLL  A 500 (-2.8A)
 0.81A 3g2oA-3hamA:
undetectable		 3g2oA-3hamA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		3 ARG A 170
GLU A 136
ASP A 356
 None
 0.76A 3g2oA-3i45A:
undetectable		 3g2oA-3i45A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF14

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF01423
(LSM) 		3 ARG e   5
GLU A 136
ASP A  81
 None
 0.83A 3g2oA-3jb9e:
undetectable		 3g2oA-3jb9e:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kbu SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		3 ARG A1697
GLU A1703
ASP A1773
 None
 0.94A 3g2oA-3kbuA:
undetectable		 3g2oA-3kbuA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		3 ARG A 259
GLU A 275
ASP A 419
 None
 0.68A 3g2oA-3oepA:
undetectable		 3g2oA-3oepA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		3 ARG A 279
GLU A 250
ASP A 225
 None
 0.88A 3g2oA-3oqnA:
undetectable		 3g2oA-3oqnA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pq1 POLY(A) RNA
POLYMERASE

(Homo sapiens) 		no annotation 3 ARG A  76
GLU A 215
ASP A 249
 None
 0.84A 3g2oA-3pq1A:
undetectable		 3g2oA-3pq1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 ARG A1337
GLU A 704
ASP A 700
 None
 0.71A 3g2oA-3ptaA:
8.3		 3g2oA-3ptaA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		3 ARG A  53
GLU A  73
ASP A  75
 None
None
NAD  A 284 (-3.7A)
 0.91A 3g2oA-3pxxA:
2.1		 3g2oA-3pxxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qbw ANHYDRO-N-ACETYLMURA
MIC ACID KINASE

(Pseudomonas
aeruginosa) 		PF03702
(AnmK) 		3 ARG A  58
GLU A  63
ASP A 127
 None
 0.64A 3g2oA-3qbwA:
undetectable		 3g2oA-3qbwA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A 469
GLU A 340
ASP A 332
 ANP  A 800 (-2.7A)
None
None
 0.94A 3g2oA-3sqwA:
3.5		 3g2oA-3sqwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CMR6

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		3 ARG H 104
GLU H 259
ASP H  65
 None
 0.88A 3g2oA-3x1lH:
undetectable		 3g2oA-3x1lH:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		3 ARG A 522
GLU A 544
ASP A 551
 None
 0.77A 3g2oA-4a2qA:
2.8		 3g2oA-4a2qA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		3 ARG A 522
GLU A 544
ASP A 551
 None
 0.84A 3g2oA-4a2wA:
undetectable		 3g2oA-4a2wA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djf CORRINOID/IRON-SULFU
R PROTEIN LARGE
SUBUNIT

(Moorella
thermoacetica) 		PF03599
(CdhD)
PF04060
(FeS) 		3 ARG C 236
GLU C 276
ASP C 296
 None
 0.75A 3g2oA-4djfC:
undetectable		 3g2oA-4djfC:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		3 ARG A 340
GLU A 365
ASP A 281
 MG  A 801 ( 4.3A)
None
None
 0.91A 3g2oA-4ex4A:
undetectable		 3g2oA-4ex4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		3 ARG A 361
GLU A 426
ASP A 419
 None
 0.72A 3g2oA-4g2rA:
undetectable		 3g2oA-4g2rA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gah THIOESTERASE
SUPERFAMILY MEMBER 4

(Homo sapiens) 		PF03061
(4HBT) 		3 ARG A  75
GLU A 122
ASP A 116
 None
 0.87A 3g2oA-4gahA:
undetectable		 3g2oA-4gahA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		3 ARG A  89
GLU A  68
ASP A 198
 None
None
KAN  A 301 (-3.0A)
 0.81A 3g2oA-4gkhA:
undetectable		 3g2oA-4gkhA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		3 ARG A1038
GLU A1139
ASP A1143
 None
 0.92A 3g2oA-4igiA:
undetectable		 3g2oA-4igiA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6e UDP-2,3-DIACYLGLUCOS
AMINE
PYROPHOSPHATASE LPXI

(Caulobacter
vibrioides) 		PF06230
(DUF1009) 		3 ARG A 236
GLU A 182
ASP A 104
 None
UDG  A 301 (-3.9A)
UDG  A 301 (-3.0A)
 0.93A 3g2oA-4j6eA:
undetectable		 3g2oA-4j6eA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		3 ARG A 177
GLU A 189
ASP A 199
 None
 0.94A 3g2oA-4jxnA:
undetectable		 3g2oA-4jxnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnf GLUTAMINE SYNTHETASE

(Bacillus
subtilis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		3 ARG A 321
GLU A 189
ASP A 158
 None
GLN  A 503 ( 2.7A)
None
 0.81A 3g2oA-4lnfA:
undetectable		 3g2oA-4lnfA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		3 ARG A  78
GLU A  60
ASP A  63
 None
 0.92A 3g2oA-4n30A:
undetectable		 3g2oA-4n30A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkj HEMAGGLUTININ HA2

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		3 ARG A  35
GLU A  42
ASP A 120
 None
 0.86A 3g2oA-4nkjA:
undetectable		 3g2oA-4nkjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ARG A2639
GLU A2525
ASP A2563
 None
 0.84A 3g2oA-4rh7A:
undetectable		 3g2oA-4rh7A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		3 ARG A  60
GLU A 373
ASP A 413
 None
 0.82A 3g2oA-4uplA:
undetectable		 3g2oA-4uplA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqz HSIE1
HSIB1

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF07024
(ImpE)
PF05591
(T6SS_VipA) 		3 ARG B  15
GLU A 273
ASP A 278
 None
 0.83A 3g2oA-4uqzB:
undetectable		 3g2oA-4uqzB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wh3 N-ACETYLHEXOSAMINE
1-KINASE

(Bifidobacterium
longum) 		PF01636
(APH) 		3 ARG A 359
GLU A 274
ASP A 118
 None
 0.87A 3g2oA-4wh3A:
undetectable		 3g2oA-4wh3A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa8 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE
NAD-BINDING

(Xanthobacter
autotrophicus) 		PF02826
(2-Hacid_dh_C) 		3 ARG A 119
GLU A 254
ASP A 275
 None
 0.93A 3g2oA-4xa8A:
7.3		 3g2oA-4xa8A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 ARG A 667
GLU A 404
ASP A 944
 None
 0.80A 3g2oA-4zhjA:
5.6		 3g2oA-4zhjA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzq CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Dictyostelium
discoideum) 		PF00840
(Glyco_hydro_7) 		3 ARG A 266
GLU A 216
ASP A 172
 None
 0.69A 3g2oA-4zzqA:
undetectable		 3g2oA-4zzqA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		3 ARG B 529
GLU B 248
ASP B 488
 None
 0.90A 3g2oA-5b3hB:
5.7		 3g2oA-5b3hB:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbj FADH2-DEPENDENT
HALOGENASE PLTA

(Pseudomonas
protegens) 		no annotation 3 ARG E  99
GLU E 102
ASP E 221
 None
 0.66A 3g2oA-5dbjE:
undetectable		 3g2oA-5dbjE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		3 ARG A 512
GLU A 536
ASP A 343
 None
 0.89A 3g2oA-5es6A:
undetectable		 3g2oA-5es6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		3 ARG A 512
GLU A 536
ASP A 343
 None
 0.88A 3g2oA-5es9A:
undetectable		 3g2oA-5es9A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ful PROTEIN ARGININE
N-METHYLTRANSFERASE
2

(Mus musculus) 		PF05175
(MTS) 		3 ARG A 133
GLU A 232
ASP A 111
 SAH  A1446 (-2.7A)
CA  A1448 ( 4.5A)
None
 0.93A 3g2oA-5fulA:
6.9		 3g2oA-5fulA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4g VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		3 ARG A 416
GLU A 408
ASP A 401
 None
 0.92A 3g2oA-5g4gA:
3.1		 3g2oA-5g4gA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 106
GLU A 439
ASP A 425
 None
 0.85A 3g2oA-5jjqA:
undetectable		 3g2oA-5jjqA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 3 ARG C 512
GLU C 536
ASP C 343
 None
 0.83A 3g2oA-5jnfC:
undetectable		 3g2oA-5jnfC:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 ARG A 611
GLU A 756
ASP A 775
 None
 0.88A 3g2oA-5kd5A:
undetectable		 3g2oA-5kd5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 ARG A 833
GLU A  79
ASP A 857
 None
 0.91A 3g2oA-5nd1A:
undetectable		 3g2oA-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd7 KINESIN-LIKE PROTEIN
KIF20A

(Mus musculus) 		PF00225
(Kinesin) 		3 ARG C 422
GLU C 310
ASP C 460
 None
 0.90A 3g2oA-5nd7C:
undetectable		 3g2oA-5nd7C:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx7 PENTALENENE SYNTHASE

(Streptomyces
clavuligerus) 		no annotation 3 ARG A 139
GLU A 194
ASP A 287
 None
 0.87A 3g2oA-5nx7A:
undetectable		 3g2oA-5nx7A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE

(Enterobacter
cloacae) 		PF01977
(UbiD) 		3 ARG A 475
GLU A 480
ASP A 482
 None
 0.61A 3g2oA-5ny5A:
undetectable		 3g2oA-5ny5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 3 ARG A 340
GLU A 361
ASP A 281
 MG  A 820 (-3.8A)
None
EDO  A 814 (-3.6A)
 0.92A 3g2oA-5oasA:
undetectable		 3g2oA-5oasA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 3 ARG A 190
GLU A 220
ASP A 269
 None
 0.81A 3g2oA-5olcA:
undetectable		 3g2oA-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		3 ARG A 172
GLU A 371
ASP A 189
 None
 0.85A 3g2oA-5opgA:
undetectable		 3g2oA-5opgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		3 ARG A 945
GLU A1244
ASP A1248
 None
 0.82A 3g2oA-5t3eA:
undetectable		 3g2oA-5t3eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3e BACILLAMIDE
SYNTHETASE
HETEROCYCLIZATION
DOMAIN

(Thermoactinomyces
vulgaris) 		PF00668
(Condensation) 		3 ARG A1109
GLU A1100
ASP A1271
 None
 0.81A 3g2oA-5t3eA:
undetectable		 3g2oA-5t3eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 ARG C 124
GLU C 121
ASP C  77
 None
 0.93A 3g2oA-5v8fC:
undetectable		 3g2oA-5v8fC:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 ARG C 124
GLU C 121
ASP C  82
 None
 0.87A 3g2oA-5v8fC:
undetectable		 3g2oA-5v8fC:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 3 ARG B 315
GLU B 396
ASP B 435
 None
 0.74A 3g2oA-5vqiB:
undetectable		 3g2oA-5vqiB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 3 ARG A 180
GLU A 188
ASP A 234
 None
 0.84A 3g2oA-5wp5A:
17.0		 3g2oA-5wp5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		3 ARG O1076
GLU O1120
ASP O1134
 None
 0.70A 3g2oA-5x0yO:
2.9		 3g2oA-5x0yO:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
RNA POLYMERASE II
SUBUNIT B12.5
RNA POLYMERASE
SUBUNIT ABC10-ALPHA

(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF13656
(RNA_pol_L_2)
PF03604
(DNA_RNApol_7kD) 		3 ARG K  37
GLU C 166
ASP L  70
 None
 0.67A 3g2oA-5xogK:
undetectable		 3g2oA-5xogK:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 ARG C 746
GLU C 713
ASP C1388
 None
 0.81A 3g2oA-5y3rC:
undetectable		 3g2oA-5y3rC:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 3 ARG A 167
GLU A 229
ASP A 295
 SAM  A 505 (-4.0A)
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
 0.63A 3g2oA-5yf0A:
undetectable		 3g2oA-5yf0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 3 ARG A  75
GLU A 118
ASP A 138
 None
 0.90A 3g2oA-6anvA:
undetectable		 3g2oA-6anvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		3 ARG A 339
GLU A 364
ASP A 280
 ACO  A 801 (-3.3A)
None
None
 0.90A 3g2oA-6axeA:
undetectable		 3g2oA-6axeA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 3 ARG A 300
GLU A 398
ASP A 404
 None
 0.60A 3g2oA-6bk7A:
undetectable		 3g2oA-6bk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv7 -

(-) 		no annotation 3 ARG A 298
GLU A 137
ASP A 203
 None
CA  A 404 (-2.9A)
None
 0.94A 3g2oA-6cv7A:
undetectable		 3g2oA-6cv7A:
undetectable