SIMILAR PATTERNS OF AMINO ACIDS FOR 3G1R_B_FITB327_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT

(Escherichia
coli) 		PF00701
(DHDPS) 		5 TYR A 210
ILE A 220
TYR A 217
ARG A 178
MET A 174
 None
 1.13A 3g1rB-1hl2A:
10.4		 3g1rB-1hl2A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		11 TYR A  26
ILE A  57
TYR A  58
TRP A  89
GLU A 120
TYR A 132
ARG A 134
TRP A 140
TRP A 230
MET A 313
TRP A 314
 CI2  A 328 ( 4.0A)
None
CI2  A 328 ( 4.5A)
None
CI2  A 328 (-4.6A)
None
None
None
CI2  A 328 (-4.2A)
CI2  A 328 (-4.0A)
None
 0.33A 3g1rB-3cavA:
55.2		 3g1rB-3cavA:
94.22