SIMILAR PATTERNS OF AMINO ACIDS FOR 3G0F_A_B49A9001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 416
ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
None
0.74A 3g0fA-1k2pA:
24.1
3g0fA-1k2pA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
6 VAL A 588
ALA A 606
TYR A 656
GLY A 660
ASP A 661
LEU A 731
None
0.57A 3g0fA-1lufA:
35.1
3g0fA-1lufA:
36.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 LEU A 267
VAL A 275
ALA A 288
THR A 334
GLY A 340
LEU A 389
P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
0.38A 3g0fA-1opkA:
30.2
3g0fA-1opkA:
26.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
CYH A 828
None
0.55A 3g0fA-1rjbA:
38.5
3g0fA-1rjbA:
56.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  78
VAL A  86
ALA A  99
GLY A 153
LEU A 201
CYH A 211
ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
ATP  A 535 ( 4.5A)
0.74A 3g0fA-1s9iA:
20.9
3g0fA-1s9iA:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
11 LEU A 595
VAL A 603
ALA A 621
THR A 670
TYR A 672
CYH A 673
GLY A 676
ASP A 677
LEU A 799
CYH A 809
PHE A 811
STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
None
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.6A)
0.76A 3g0fA-1t46A:
41.9
3g0fA-1t46A:
92.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
6 VAL A  42
ALA A  55
TYR A 107
CYH A 108
GLY A 110
LEU A 158
None
0.55A 3g0fA-1u5qA:
23.0
3g0fA-1u5qA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  15
VAL A  23
ALA A  36
TYR A  86
CYH A  87
GLY A  90
LEU A 137
HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
0.42A 3g0fA-1zltA:
20.7
3g0fA-1zltA:
27.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU X  17
VAL X  25
ALA X  37
THR X  82
TYR X  84
GLY X  88
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
0.47A 3g0fA-2dq7X:
30.3
3g0fA-2dq7X:
35.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
6 VAL A  42
ALA A  55
TYR A 107
CYH A 108
GLY A 110
LEU A 158
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 (-4.5A)
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
0.52A 3g0fA-2gcdA:
24.0
3g0fA-2gcdA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 LEU A 273
VAL A 281
ALA A 293
THR A 338
TYR A 340
GLY A 344
LEU A 393
H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
0.75A 3g0fA-2h8hA:
28.1
3g0fA-2h8hA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  55
VAL A  63
ALA A  76
GLY A 130
LEU A 177
CYH A 190
None
0.68A 3g0fA-2hw6A:
20.3
3g0fA-2hw6A:
23.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 248
VAL A 256
ALA A 269
THR A 315
GLY A 321
LEU A 370
GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
0.58A 3g0fA-2hz0A:
31.2
3g0fA-2hz0A:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 251
VAL A 259
ALA A 271
THR A 316
TYR A 318
GLY A 322
PHE A 383
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1.04A 3g0fA-2og8A:
16.6
3g0fA-2og8A:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 259
ALA A 271
THR A 316
TYR A 318
GLY A 322
LEU A 371
PHE A 383
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 4.3A)
0.99A 3g0fA-2og8A:
16.6
3g0fA-2og8A:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 588
VAL A 596
ALA A 614
THR A 663
TYR A 665
CYH A 666
GLY A 669
ASP A 670
LEU A 785
None
0.49A 3g0fA-2ogvA:
38.9
3g0fA-2ogvA:
67.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
None
0.43A 3g0fA-2psqA:
25.0
3g0fA-2psqA:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
6 VAL A 689
ALA A 705
THR A 753
TYR A 755
GLY A 759
LEU A 807
None
0.75A 3g0fA-2r2pA:
24.0
3g0fA-2r2pA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  90
ALA A 103
TYR A 155
GLY A 159
ASP A 160
LEU A 205
None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
ANP  A1480 (-4.0A)
ANP  A1480 ( 4.7A)
0.58A 3g0fA-2v55A:
18.6
3g0fA-2v55A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  85
ALA A  98
TYR A 150
GLY A 154
ASP A 155
LEU A 202
BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.8A)
None
None
BI8  A1417 (-4.8A)
0.66A 3g0fA-2vd5A:
20.1
3g0fA-2vd5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
6 LEU C  55
VAL C  63
ALA C  76
TYR C 131
CYH C 132
LEU C 183
ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
ANP  C   2 (-4.5A)
None
0.64A 3g0fA-2wtkC:
21.8
3g0fA-2wtkC:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  68
VAL A  76
ALA A  92
GLY A 147
ASP A 148
LEU A 194
STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 ( 3.9A)
STU  A   1 (-3.8A)
STU  A   1 (-4.6A)
0.31A 3g0fA-2z7rA:
21.6
3g0fA-2z7rA:
27.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
0.46A 3g0fA-3b2tA:
33.2
3g0fA-3b2tA:
47.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
PHE A 489
C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
0.66A 3g0fA-3c4fA:
24.3
3g0fA-3c4fA:
46.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 833
VAL A 841
ALA A 859
CYH A 912
GLY A 915
LEU A1029
CYH A1039
PHE A1041
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
8ST  A2001 ( 3.7A)
0.81A 3g0fA-3hngA:
40.3
3g0fA-3hngA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 833
VAL A 841
ALA A 859
TYR A 911
CYH A 912
GLY A 915
LEU A1029
CYH A1039
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
0.60A 3g0fA-3hngA:
40.3
3g0fA-3hngA:
45.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 696
VAL A 704
THR A 768
TYR A 770
GLY A 774
LEU A 822
ANP  A   1 (-4.4A)
ANP  A   1 (-3.9A)
ANP  A   1 ( 4.8A)
ANP  A   1 (-4.3A)
ANP  A   1 ( 4.9A)
ANP  A   1 (-4.7A)
0.72A 3g0fA-3kexA:
26.3
3g0fA-3kexA:
28.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
0.45A 3g0fA-3lm5A:
23.4
3g0fA-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
6 VAL A 218
ALA A 229
THR A 279
TYR A 281
GLY A 285
LEU A 339
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
0.66A 3g0fA-3mdyA:
23.7
3g0fA-3mdyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 171
VAL A 179
ALA A 192
TYR A 242
ASP A 246
LEU A 293
FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-4.2A)
0.72A 3g0fA-3mtlA:
21.0
3g0fA-3mtlA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  49
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
0.43A 3g0fA-3mvjA:
21.7
3g0fA-3mvjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  88
VAL A  96
ALA A 109
TYR A 161
GLY A 165
LEU A 212
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
0.37A 3g0fA-3nuuA:
23.2
3g0fA-3nuuA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6


(Homo sapiens)
PF00069
(Pkinase)
PF00615
(RGS)
6 LEU A 192
VAL A 200
ALA A 213
GLY A 269
ASP A 270
LEU A 318
AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.8A)
0.68A 3g0fA-3nyoA:
21.4
3g0fA-3nyoA:
23.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
7 VAL A 565
ALA A 576
THR A 625
TYR A 627
GLY A 631
LEU A 683
CYH A 693
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
0.77A 3g0fA-3ppzA:
26.9
3g0fA-3ppzA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 LEU A  63
VAL A  71
ALA A  84
THR A 144
GLY A 150
LEU A 197
ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
0.34A 3g0fA-3q5iA:
20.0
3g0fA-3q5iA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  90
ALA A 103
TYR A 155
GLY A 159
ASP A 160
LEU A 207
NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
NM7  A 416 (-4.4A)
None
None
NM7  A 416 ( 4.2A)
0.67A 3g0fA-3qfvA:
15.2
3g0fA-3qfvA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 423
VAL A 431
ALA A 443
THR A 489
TYR A 491
GLY A 495
LEU A 543
PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
0.76A 3g0fA-3sxsA:
24.6
3g0fA-3sxsA:
34.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
0.31A 3g0fA-3tt0A:
33.6
3g0fA-3tt0A:
42.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 LEU A 361
VAL A 369
ALA A 382
GLY A 439
ASP A 440
LEU A 486
07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
07U  A   1 (-3.9A)
07U  A   1 (-4.3A)
0.51A 3g0fA-3txoA:
18.7
3g0fA-3txoA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 544
VAL A 552
ALA A 570
TYR A 619
GLY A 623
ASP A 624
LEU A 686
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
0.65A 3g0fA-3v5qA:
31.8
3g0fA-3v5qA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 552
ALA A 570
TYR A 619
GLY A 623
ASP A 624
LEU A 686
PHE A 698
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
0F4  A 902 (-4.1A)
1.19A 3g0fA-3v5qA:
31.8
3g0fA-3v5qA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
0.30A 3g0fA-3vidA:
35.1
3g0fA-3vidA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 840
VAL A 848
CYH A 919
GLY A 922
LEU A1035
CYH A1045
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
0.73A 3g0fA-3vidA:
35.1
3g0fA-3vidA:
46.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens)
PF00069
(Pkinase)
6 LEU A 139
VAL A 147
ALA A 160
TYR A 212
GLY A 216
LEU A 263
N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
0.29A 3g0fA-3w18A:
21.8
3g0fA-3w18A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
0.71A 3g0fA-3wzdA:
33.6
3g0fA-3wzdA:
52.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  83
VAL A  91
ALA A 104
TYR A 156
GLY A 160
LEU A 207
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
0.45A 3g0fA-4af3A:
19.7
3g0fA-4af3A:
27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 840
VAL A 848
ALA A 866
CYH A 919
GLY A 922
LEU A1035
CYH A1045
PHE A1047
B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
B49  A2000 (-4.0A)
0.75A 3g0fA-4agdA:
39.5
3g0fA-4agdA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  18
ALA A  31
TYR A  82
CYH A  83
LEU A 133
CYH A 143
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 (-4.8A)
D15  A 500 (-4.3A)
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
0.68A 3g0fA-4aguA:
22.8
3g0fA-4aguA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 560
VAL A 568
ALA A 586
TYR A 635
GLY A 639
ASP A 640
LEU A 699
LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
0.70A 3g0fA-4at3A:
30.7
3g0fA-4at3A:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA


(Rattus
norvegicus)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
6 VAL A  91
ALA A 104
TYR A 156
GLY A 160
ASP A 161
LEU A 208
None
EDO  A1420 (-3.4A)
EDO  A1420 (-4.9A)
None
None
EDO  A1420 ( 4.8A)
0.44A 3g0fA-4aw2A:
19.9
3g0fA-4aw2A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  42
VAL A  50
ALA A  63
CYH A 113
GLY A 116
LEU A 164
XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
0.74A 3g0fA-4bc6A:
20.9
3g0fA-4bc6A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
6 LEU A 246
VAL A 254
ALA A 267
TYR A 320
GLY A 324
LEU A 371
None
0.41A 3g0fA-4c0tA:
22.8
3g0fA-4c0tA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Rattus
norvegicus)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
0.59A 3g0fA-4cfhA:
22.6
3g0fA-4cfhA:
20.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 LEU A 616
VAL A 624
ALA A 653
THR A 701
TYR A 703
GLY A 707
ASP A 708
PHE A 785
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
None
DI1  A1000 (-4.5A)
1.00A 3g0fA-4ckrA:
32.4
3g0fA-4ckrA:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 624
ALA A 653
THR A 701
TYR A 703
GLY A 707
ASP A 708
LEU A 773
PHE A 785
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
0.89A 3g0fA-4ckrA:
32.4
3g0fA-4ckrA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
ASP A 744
LEU A 789
AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.0A)
AGS  A1985 (-4.8A)
0.53A 3g0fA-4crsA:
20.9
3g0fA-4crsA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 LEU A 515
VAL A 523
ALA A 541
TYR A 590
GLY A 594
ASP A 595
LEU A 656
None
0.79A 3g0fA-4f0iA:
32.0
3g0fA-4f0iA:
35.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 828
VAL A 836
ALA A 853
TYR A 904
GLY A 908
LEU A 956
19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
0.49A 3g0fA-4hviA:
29.2
3g0fA-4hviA:
31.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
6 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
None
0.62A 3g0fA-4hzsA:
18.4
3g0fA-4hzsA:
32.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 132
VAL A 140
ALA A 156
THR A 205
GLY A 211
LEU A 259
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
0.68A 3g0fA-4id7A:
29.4
3g0fA-4id7A:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Homo sapiens)
PF00069
(Pkinase)
6 LEU A  18
VAL A  26
ALA A  39
CYH A  92
GLY A  95
LEU A 143
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
0.47A 3g0fA-4jxfA:
18.1
3g0fA-4jxfA:
25.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 478
VAL A 486
ALA A 506
TYR A 557
GLY A 561
LEU A 624
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
0.77A 3g0fA-4k33A:
33.6
3g0fA-4k33A:
47.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  33
VAL A  41
ALA A  54
TYR A 101
CYH A 102
GLY A 105
ASP A 109
GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
None
0.95A 3g0fA-4lg4A:
17.1
3g0fA-4lg4A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  41
ALA A  54
TYR A 101
CYH A 102
GLY A 105
LEU A 153
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 404 ( 4.9A)
GOL  A 403 (-4.0A)
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
0.71A 3g0fA-4lg4A:
17.1
3g0fA-4lg4A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2


(Plasmodium
falciparum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 LEU A  78
VAL A  86
ALA A  99
CYH A 149
GLY A 151
LEU A 199
STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
0.61A 3g0fA-4mvfA:
19.0
3g0fA-4mvfA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  46
VAL A  54
ALA A  67
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
0.70A 3g0fA-4o38A:
20.1
3g0fA-4o38A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
0.58A 3g0fA-4oliA:
26.6
3g0fA-4oliA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 LEU A 627
VAL A 635
ALA A 648
TYR A 703
GLY A 707
ASP A 708
LEU A 753
None
0.57A 3g0fA-4otdA:
21.9
3g0fA-4otdA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 LEU A 386
VAL A 394
ALA A 407
TYR A 460
GLY A 464
ASP A 465
LEU A 511
PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
0.75A 3g0fA-4q9zA:
20.4
3g0fA-4q9zA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
6 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
0.53A 3g0fA-4rewA:
22.1
3g0fA-4rewA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
CYH A 828
PHE A 830
P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.9A)
0.70A 3g0fA-4rt7A:
39.9
3g0fA-4rt7A:
48.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
7 LEU A  14
VAL A  22
ALA A  35
THR A  81
TYR A  83
GLY A  87
LEU A 136
ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
0.76A 3g0fA-4ueuA:
30.7
3g0fA-4ueuA:
35.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA


(Homo sapiens)
PF00069
(Pkinase)
PF00226
(DnaJ)
6 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
0.45A 3g0fA-4wb7A:
21.5
3g0fA-4wb7A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus)
PF00069
(Pkinase)
PF00615
(RGS)
6 LEU A 193
VAL A 201
ALA A 214
GLY A 270
ASP A 271
LEU A 321
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
0.55A 3g0fA-4wboA:
22.6
3g0fA-4wboA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wov NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 595
VAL A 603
THR A 687
TYR A 689
GLY A 693
LEU A 741
3SM  A 901 (-3.9A)
3SM  A 901 ( 4.4A)
3SM  A 901 ( 4.6A)
3SM  A 901 (-3.2A)
3SM  A 901 (-3.0A)
3SM  A 901 (-4.1A)
0.76A 3g0fA-4wovA:
21.0
3g0fA-4wovA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 LEU A  52
VAL A  60
ALA A  72
CYH A 129
GLY A 132
LEU A 183
CYH A 193
KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
0.63A 3g0fA-4wsqA:
22.2
3g0fA-4wsqA:
22.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 LEU A 616
VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
PHE A 830
P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
0.57A 3g0fA-4xufA:
39.2
3g0fA-4xufA:
60.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 624
ALA A 642
TYR A 693
CYH A 694
GLY A 697
ASP A 698
LEU A 818
CYH A 828
PHE A 830
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
P30  A1001 ( 4.1A)
0.72A 3g0fA-4xufA:
39.2
3g0fA-4xufA:
60.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
7 LEU A 408
VAL A 416
ALA A 428
THR A 474
TYR A 476
GLY A 480
LEU A 528
746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
746  A 702 (-3.6A)
746  A 702 (-4.4A)
0.64A 3g0fA-4y93A:
29.2
3g0fA-4y93A:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 477
ALA A 488
THR A 539
TYR A 541
GLY A 545
LEU A 595
None
4CV  A 801 (-3.5A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
0.52A 3g0fA-4yffA:
11.7
3g0fA-4yffA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 LEU A  34
VAL A  42
ALA A  55
THR A 105
GLY A 111
LEU A 158
ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
0.47A 3g0fA-4ysjA:
22.2
3g0fA-4ysjA:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
0.35A 3g0fA-5a46A:
33.7
3g0fA-5a46A:
41.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  30
ALA A  44
TYR A  94
CYH A  95
GLY A  98
ASP A  99
LEU A 145
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
51W  A 401 ( 3.4A)
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
51W  A 401 (-3.8A)
51W  A 401 (-4.5A)
0.30A 3g0fA-5ci7A:
23.1
3g0fA-5ci7A:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 258
ALA A 275
THR A 325
GLY A 331
LEU A 386
CYH A 396
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
0.76A 3g0fA-5e8yA:
13.6
3g0fA-5e8yA:
27.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
0.47A 3g0fA-5f1zA:
22.6
3g0fA-5f1zA:
32.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
11 LEU A 599
VAL A 607
ALA A 625
THR A 674
TYR A 676
CYH A 677
GLY A 680
ASP A 681
LEU A 825
CYH A 835
PHE A 837
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-3.7A)
0.68A 3g0fA-5grnA:
31.4
3g0fA-5grnA:
60.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 VAL A  94
ALA A 105
THR A 148
TYR A 150
GLY A 154
LEU A 215
None
0.64A 3g0fA-5gz8A:
18.5
3g0fA-5gz8A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
8 LEU A  57
VAL A  65
ALA A  77
TYR A 132
CYH A 133
GLY A 136
LEU A 187
CYH A 197
IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
0.76A 3g0fA-5i3oA:
22.0
3g0fA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2


(Homo sapiens)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.5A)
0.31A 3g0fA-5isoA:
22.5
3g0fA-5isoA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  49
ALA A  60
TYR A 112
GLY A 116
ASP A 117
LEU A 163
None
STU  A 901 (-3.3A)
STU  A 901 (-4.6A)
STU  A 901 (-3.5A)
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
0.40A 3g0fA-5lohA:
16.6
3g0fA-5lohA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0y SERINE/THREONINE-PRO
TEIN KINASE
TOUSLED-LIKE 2


(Homo sapiens)
no annotation 6 LEU A 468
VAL A 476
ALA A 489
TYR A 546
CYH A 547
GLY A 549
AGS  A 801 (-4.1A)
AGS  A 801 (-4.0A)
AGS  A 801 (-3.6A)
AGS  A 801 ( 4.8A)
AGS  A 801 (-4.3A)
None
0.61A 3g0fA-5o0yA:
20.9
3g0fA-5o0yA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE


(Homo sapiens)
no annotation 6 VAL A  25
ALA A  38
TYR A  88
CYH A  89
GLY A  92
LEU A 139
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-4.6A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
0.39A 3g0fA-5tvtA:
22.4
3g0fA-5tvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 106
ALA A 119
TYR A 171
GLY A 175
ASP A 176
LEU A 221
None
0.42A 3g0fA-5u7qA:
19.3
3g0fA-5u7qA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 7 LEU A  24
VAL A  32
ALA A  45
THR A  95
TYR A  97
GLY A 101
LEU A 153
9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
0.60A 3g0fA-5w5jA:
22.6
3g0fA-5w5jA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 LEU A 891
VAL A 899
ALA A 917
THR A 963
TYR A 965
GLY A 969
ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
0.57A 3g0fA-5wnoA:
25.6
3g0fA-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 LEU A 891
VAL A 899
ALA A 917
TYR A 965
GLY A 969
LEU A1017
ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
0.60A 3g0fA-5wnoA:
25.6
3g0fA-5wnoA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 7 LEU A  33
VAL A  41
ALA A  54
TYR A 101
CYH A 102
GLY A 105
LEU A 153
ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
0.75A 3g0fA-6ao5A:
20.9
3g0fA-6ao5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2


(Homo sapiens)
no annotation 6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
EDJ  A 301 (-3.9A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 3.7A)
EDJ  A 301 ( 4.5A)
0.53A 3g0fA-6bx6A:
18.8
3g0fA-6bx6A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 7 LEU U  20
VAL U  28
ALA U  42
CYH U  94
GLY U  97
ASP U  98
LEU U 144
DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
None
DB8  U 301 (-4.8A)
0.75A 3g0fA-6fdyU:
21.6
3g0fA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
no annotation 6 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
0.75A 3g0fA-6fekA:
31.8
3g0fA-6fekA:
19.23