SIMILAR PATTERNS OF AMINO ACIDS FOR 3FZG_A_SAMA300

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b35 PROTEIN (CRICKET
PARALYSIS VIRUS,
VP2)

(Cricket
paralysis virus) 		no annotation 5 HIS B 193
PHE B 248
GLY B 201
GLY B 203
LEU B 198
 None
 1.23A 3fzgA-1b35B:
undetectable		 3fzgA-1b35B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		5 THR A  37
GLY A 102
GLY A 129
LEU A  35
VAL A  57
 None
SAH  A 300 (-3.5A)
None
None
None
 1.12A 3fzgA-1cbfA:
undetectable		 3fzgA-1cbfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 SER A 111
ILE A  89
LEU A 136
MET A 134
VAL A 120
 None
 1.19A 3fzgA-1cjyA:
undetectable		 3fzgA-1cjyA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		5 SER A 230
THR A 231
ILE A 572
MET A 209
VAL A 208
 None
 1.21A 3fzgA-1cjyA:
undetectable		 3fzgA-1cjyA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 168
ILE A 201
LEU A 164
VAL A 140
GLN A 100
 CAA  A 600 (-3.3A)
None
None
None
None
 1.30A 3fzgA-1ee0A:
undetectable		 3fzgA-1ee0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens) 		PF00082
(Peptidase_S8) 		5 SER A 163
THR A 164
GLY A 169
GLY A 166
LEU A 196
 None
 1.00A 3fzgA-1gnsA:
undetectable		 3fzgA-1gnsA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8d RIBOFLAVIN SYNTHASE

(Escherichia
coli) 		PF00677
(Lum_binding) 		5 GLY A   4
GLY A  96
ILE A 145
LEU A  98
MET A  99
 None
 1.09A 3fzgA-1i8dA:
undetectable		 3fzgA-1i8dA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		5 GLY A 342
GLY A 290
ILE A 261
LEU A 347
GLN A  94
 None
 0.90A 3fzgA-1l5jA:
undetectable		 3fzgA-1l5jA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8w VLSE1

(Borreliella
burgdorferi) 		PF00921
(Lipoprotein_2) 		5 SER A 163
GLY A 288
GLY A 293
LEU A 286
VAL A  70
 None
 1.14A 3fzgA-1l8wA:
undetectable		 3fzgA-1l8wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLY A   2
GLY A   4
LEU A  25
MET A  28
GLN A1311
 None
 0.94A 3fzgA-1ofeA:
undetectable		 3fzgA-1ofeA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		5 THR A 232
GLY A 302
GLY A 329
LEU A 230
VAL A 251
 None
ACT  A 505 (-3.0A)
None
None
None
 1.15A 3fzgA-1pjqA:
undetectable		 3fzgA-1pjqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlw PHOSPHOLIPASE A2

(Homo sapiens) 		PF00168
(C2) 		5 SER A 111
ILE A  89
LEU A 136
MET A 134
VAL A 120
 None
 1.16A 3fzgA-1rlwA:
undetectable		 3fzgA-1rlwA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A1248
GLY A1252
LEU A1246
VAL A1358
GLN A1324
 None
None
None
None
NAP  A1453 (-2.6A)
 1.28A 3fzgA-1tllA:
2.8		 3fzgA-1tllA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tll NITRIC-OXIDE
SYNTHASE, BRAIN

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 GLY A1350
GLY A1252
LEU A1399
MET A1354
VAL A1358
 None
None
NAP  A1453 (-3.8A)
None
None
 1.17A 3fzgA-1tllA:
2.8		 3fzgA-1tllA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		5 HIS A 113
SER A 112
PHE A  77
ILE A 121
LEU A 117
 ZN  A 400 (-3.2A)
None
None
None
None
 1.13A 3fzgA-1u10A:
undetectable		 3fzgA-1u10A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u83 PHOSPHOSULFOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF02679
(ComA) 		5 SER A  54
THR A  53
PHE A  81
GLY A  77
ILE A 105
 None
None
None
PO4  A1000 (-3.3A)
None
 1.23A 3fzgA-1u83A:
undetectable		 3fzgA-1u83A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		5 THR A  18
GLY A  85
GLY A 112
LEU A  16
VAL A  37
 None
SAH  A 501 (-3.5A)
None
None
None
 1.25A 3fzgA-1v9aA:
undetectable		 3fzgA-1v9aA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 HIS A  89
SER A  87
THR A  88
GLY A 168
LEU A 165
 GLC  A 900 (-4.0A)
GLC  A 900 ( 4.3A)
None
None
None
 1.15A 3fzgA-1venA:
undetectable		 3fzgA-1venA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		5 HIS A  89
SER A  87
THR A  88
GLY A 171
LEU A 165
 GLC  A 900 (-4.0A)
GLC  A 900 ( 4.3A)
None
GLC  A 900 ( 4.9A)
None
 1.26A 3fzgA-1venA:
undetectable		 3fzgA-1venA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrg PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Thermotoga
maritima) 		PF01039
(Carboxyl_trans) 		5 GLY A 144
GLY A 146
ILE A 110
LEU A 142
GLN A  93
 None
 1.26A 3fzgA-1vrgA:
undetectable		 3fzgA-1vrgA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 THR A 317
GLY A 293
GLY A 291
MET A 140
VAL A 137
 CO  A1001 ( 4.9A)
None
None
None
None
 1.15A 3fzgA-1wn1A:
undetectable		 3fzgA-1wn1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 SER A 180
THR A 179
GLY A 282
GLY A 316
VAL A 261
 TYR  A 888 (-2.7A)
None
TYR  A 888 ( 4.0A)
TYR  A 888 (-3.6A)
TYR  A 888 (-4.7A)
 0.99A 3fzgA-2amcA:
undetectable		 3fzgA-2amcA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 SER A 211
GLY A  41
GLY A  70
LEU A  43
VAL A  90
 None
 1.24A 3fzgA-2b6nA:
undetectable		 3fzgA-2b6nA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		5 THR A  37
GLY A 102
GLY A 129
LEU A  35
VAL A  57
 None
SAH  A 300 (-3.4A)
None
None
None
 1.22A 3fzgA-2cbfA:
undetectable		 3fzgA-2cbfA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		5 THR A 236
GLY A 143
ILE A 123
LEU A 247
MET A 250
 None
 1.17A 3fzgA-2cxiA:
undetectable		 3fzgA-2cxiA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		5 HIS A 266
GLY A 238
LEU A 240
VAL A 113
GLN A 115
 GOL  A 401 ( 4.7A)
None
None
None
None
 1.29A 3fzgA-2f8lA:
9.5		 3fzgA-2f8lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		5 THR A 147
GLY A 217
GLY A 123
ILE A 120
VAL A 223
 None
 1.25A 3fzgA-2f9tA:
undetectable		 3fzgA-2f9tA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu3 YPMB PROTEIN

(Bacillus
subtilis) 		PF03413
(PepSY) 		5 THR A 151
GLY A 153
LEU A 131
VAL A 121
GLN A 118
 None
 1.11A 3fzgA-2gu3A:
undetectable		 3fzgA-2gu3A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 HIS A 201
PHE A  49
GLY A 105
GLY A 181
ILE A 178
 None
 1.18A 3fzgA-2isnA:
undetectable		 3fzgA-2isnA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 THR B 105
GLY B 118
LEU B 103
MET B 128
VAL B  49
 None
HEC  B 250 ( 4.3A)
None
None
None
 1.14A 3fzgA-2jxmB:
undetectable		 3fzgA-2jxmB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0o TNF SUPERFAMILY
LIGAND TL1A

(Homo sapiens) 		PF00229
(TNF) 		5 THR A 182
GLY A 197
ILE A 177
LEU A 195
VAL A 153
 None
 1.21A 3fzgA-2o0oA:
undetectable		 3fzgA-2o0oA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qng UNCHARACTERIZED
PROTEIN SAV2460

(Streptomyces
avermitilis) 		PF02342
(TerD) 		5 GLY A 141
GLY A  95
LEU A 115
MET A 117
VAL A  11
 None
 1.30A 3fzgA-2qngA:
undetectable		 3fzgA-2qngA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		5 GLY A 115
GLY A 170
ILE A 173
LEU A 122
VAL A 180
 None
 1.28A 3fzgA-2radA:
1.2		 3fzgA-2radA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7b BENZOATE-COENZYME A
LIGASE

(Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 HIS A 339
THR A 211
GLY A 243
GLY A 241
VAL A 277
 BEZ  A1529 (-3.8A)
None
None
None
None
 0.93A 3fzgA-2v7bA:
undetectable		 3fzgA-2v7bA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		5 SER A  61
THR A  60
GLY A 151
ILE A 172
VAL A  55
 None
COA  A1383 ( 4.9A)
None
None
None
 0.93A 3fzgA-2vatA:
2.5		 3fzgA-2vatA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xr7 MALONYLTRANSFERASE

(Nicotiana
tabacum) 		PF02458
(Transferase) 		5 THR A  25
GLY A 320
ILE A 173
LEU A  22
VAL A 144
 None
 0.79A 3fzgA-2xr7A:
undetectable		 3fzgA-2xr7A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		5 THR A  34
GLY A 104
GLY A 131
LEU A  32
VAL A  53
 None
SAH  A1267 (-3.5A)
None
None
None
 1.12A 3fzgA-2ybqA:
undetectable		 3fzgA-2ybqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 SER A 368
THR A 369
GLY A 403
ILE A 444
VAL A 615
 None
None
CA  A 621 ( 4.7A)
None
None
 0.83A 3fzgA-2z8zA:
undetectable		 3fzgA-2z8zA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 HIS A 335
THR A 311
GLY A 358
GLY A 336
LEU A 360
 None
None
None
None
MPD  A 402 ( 4.7A)
 1.19A 3fzgA-3a71A:
undetectable		 3fzgA-3a71A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE

(Mesorhizobium
japonicum) 		PF01494
(FAD_binding_3) 		5 SER A  43
PHE A  21
GLY A  20
GLY A  18
LEU A  46
 FAD  A 380 (-3.5A)
FAD  A 380 (-4.7A)
FAD  A 380 (-3.4A)
FAD  A 380 (-3.3A)
None
 1.29A 3fzgA-3allA:
undetectable		 3fzgA-3allA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		5 SER A  92
GLY A 427
ILE A 431
LEU A  81
GLN A 357
 HEM  A 801 (-3.5A)
None
None
None
None
 1.21A 3fzgA-3ayfA:
undetectable		 3fzgA-3ayfA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		5 HIS A  81
SER A  83
GLY A 113
ILE A 132
LYS A 174
 5GP  A 500 (-4.7A)
5GP  A 500 (-2.7A)
5GP  A 500 ( 4.5A)
5GP  A 500 (-4.1A)
5GP  A 500 (-4.9A)
 0.98A 3fzgA-3b89A:
21.6		 3fzgA-3b89A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		5 SER A  83
THR A  84
GLY A 113
ILE A 132
LYS A 174
 5GP  A 500 (-2.7A)
None
5GP  A 500 ( 4.5A)
5GP  A 500 (-4.1A)
5GP  A 500 (-4.9A)
 0.96A 3fzgA-3b89A:
21.6		 3fzgA-3b89A:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9y AMMONIUM TRANSPORTER
FAMILY RH-LIKE
PROTEIN

(Nitrosomonas
europaea) 		PF00909
(Ammonium_transp) 		5 GLY A 361
GLY A 365
ILE A 359
LEU A 134
VAL A 141
 None
 1.26A 3fzgA-3b9yA:
undetectable		 3fzgA-3b9yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG

(Sulfolobus
solfataricus) 		PF01890
(CbiG_C)
PF11760
(CbiG_N) 		5 SER A 217
THR A 333
GLY A 311
LEU A 307
VAL A 273
 None
 1.21A 3fzgA-3eeqA:
undetectable		 3fzgA-3eeqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 145
GLY A 186
LEU A 150
VAL A 156
GLN A 212
 ANP  A 480 ( 3.5A)
None
None
None
None
 1.23A 3fzgA-3fhtA:
3.2		 3fzgA-3fhtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 222
GLY A 177
ILE A 220
LEU A 189
VAL A 194
 None
 1.14A 3fzgA-3fw8A:
undetectable		 3fzgA-3fw8A:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzg 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		12 HIS A  83
SER A  85
THR A  86
PHE A 113
GLY A 114
GLY A 116
ILE A 138
LEU A 179
LYS A 180
MET A 181
VAL A 184
GLN A 188
 SAM  A 300 (-4.4A)
SAM  A 300 (-3.1A)
SAM  A 300 (-4.7A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.5A)
SAM  A 300 ( 3.7A)
SAM  A 300 (-3.7A)
SAM  A 300 (-4.0A)
SAM  A 300 (-4.7A)
SAM  A 300 (-3.0A)
None
SAM  A 300 (-3.3A)
 0.00A 3fzgA-3fzgA:
37.6		 3fzgA-3fzgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 SER A 456
THR A 382
GLY A 379
LEU A 334
VAL A 514
 None
 1.28A 3fzgA-3higA:
undetectable		 3fzgA-3higA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr3 NAD-DEPENDENT
DEACETYLASE

(Thermotoga
maritima) 		PF02146
(SIR2) 		5 SER A  25
THR A  26
GLY A 188
ILE A 185
VAL A  95
 None
 1.20A 3fzgA-3jr3A:
undetectable		 3fzgA-3jr3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kb6 D-LACTATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 THR A 292
PHE A 249
GLY A 253
ILE A 198
VAL A 235
 None
 1.23A 3fzgA-3kb6A:
5.0		 3fzgA-3kb6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		8 HIS B 102
SER B 104
THR B 105
GLY B 135
ILE B 157
LEU B 198
LYS B 199
GLN B 207
 SAM  B 301 (-4.3A)
SAM  B 301 (-3.0A)
SAM  B 301 (-3.8A)
SAM  B 301 ( 4.1A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.1A)
SAM  B 301 (-4.9A)
SAM  B 301 (-3.3A)
 0.58A 3fzgA-3lcvB:
19.9		 3fzgA-3lcvB:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcv SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM

(Micromonospora
zionensis) 		PF07091
(FmrO) 		6 HIS B 102
SER B 104
THR B 105
ILE B  60
LEU B 198
LYS B 199
 SAM  B 301 (-4.3A)
SAM  B 301 (-3.0A)
SAM  B 301 (-3.8A)
SAM  B 301 (-4.2A)
SAM  B 301 (-4.1A)
SAM  B 301 (-4.9A)
 1.45A 3fzgA-3lcvB:
19.9		 3fzgA-3lcvB:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans) 		PF01039
(Carboxyl_trans) 		5 GLY B 175
GLY B 177
ILE B 141
LEU B 173
GLN B 124
 None
 1.23A 3fzgA-3n6rB:
undetectable		 3fzgA-3n6rB:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		5 THR A  17
GLY A  82
GLY A 109
LEU A  15
VAL A  37
 None
SAH  A 300 ( 3.8A)
None
None
None
 1.14A 3fzgA-3ndcA:
undetectable		 3fzgA-3ndcA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nip 3-GUANIDINOPROPIONAS
E

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 SER A 121
GLY A  89
GLY A  41
LEU A  39
GLN A 111
 None
 1.23A 3fzgA-3nipA:
undetectable		 3fzgA-3nipA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o63 PROBABLE
THIAMINE-PHOSPHATE
PYROPHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF02581
(TMP-TENI) 		5 HIS A 122
SER A 120
THR A 121
GLY A 177
GLY A 141
 PO4  A 223 (-4.3A)
PO4  A 223 ( 4.2A)
None
None
None
 1.08A 3fzgA-3o63A:
undetectable		 3fzgA-3o63A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		5 THR A 225
PHE A  69
GLY A  72
ILE A  18
VAL A  98
 None
 1.14A 3fzgA-3o7oA:
undetectable		 3fzgA-3o7oA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A  17
ILE A  12
LEU A  59
LYS A  61
VAL A  63
 None
 1.14A 3fzgA-3otrA:
undetectable		 3fzgA-3otrA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t69 PUTATIVE
2-DEHYDRO-3-DEOXYGAL
ACTONOKINASE

(Sinorhizobium
meliloti) 		PF05035
(DGOK) 		5 THR A  99
GLY A  71
GLY A  74
LEU A 111
VAL A  12
 None
 1.17A 3fzgA-3t69A:
undetectable		 3fzgA-3t69A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d) 		5 SER A 180
THR A 179
GLY A 282
GLY A 316
VAL A 261
 DAH  A 351 (-2.9A)
None
DAH  A 351 (-4.0A)
DAH  A 351 (-2.9A)
DAH  A 351 (-4.6A)
 0.97A 3fzgA-3tehA:
undetectable		 3fzgA-3tehA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		5 HIS A  81
SER A  79
THR A  80
GLY A 159
LEU A 156
 None
 1.14A 3fzgA-3vocA:
undetectable		 3fzgA-3vocA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		5 HIS A  81
SER A  79
THR A  80
GLY A 162
LEU A 156
 None
 1.26A 3fzgA-3vocA:
undetectable		 3fzgA-3vocA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e79 UDP-3-O-ACYLGLUCOSAM
INE
N-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF04613
(LpxD)
PF14602
(Hexapep_2) 		5 THR A 297
GLY A 259
GLY A 277
ILE A 254
VAL A 246
 None
 1.12A 3fzgA-4e79A:
undetectable		 3fzgA-4e79A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis) 		PF13649
(Methyltransf_25) 		5 SER A  72
GLY A  52
GLY A  50
LEU A  77
MET A  76
 None
 1.12A 3fzgA-4hgzA:
11.0		 3fzgA-4hgzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 GLY A 133
GLY A 129
ILE A 232
LEU A  50
VAL A  56
 None
 1.14A 3fzgA-4ia4A:
undetectable		 3fzgA-4ia4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		5 SER A 192
THR A 191
GLY A 204
GLY A 207
LEU A 201
 None
None
None
CL  A 402 ( 3.7A)
None
 1.27A 3fzgA-4infA:
undetectable		 3fzgA-4infA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf7 HEMAGGLUTININ-NEURAM
INIDASE

(Mammalian
rubulavirus 5) 		no annotation 5 HIS D 173
THR D 172
GLY D 234
ILE D 263
VAL D 301
 None
None
NAG  D 604 (-3.7A)
None
None
 1.17A 3fzgA-4jf7D:
undetectable		 3fzgA-4jf7D:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		5 PHE A 212
GLY A 211
GLY A 251
ILE A 189
VAL A 228
 None
 1.04A 3fzgA-4l7aA:
undetectable		 3fzgA-4l7aA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leu PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT3G46870

(Arabidopsis
thaliana) 		PF13041
(PPR_2) 		5 LEU A 125
LYS A 128
MET A 129
VAL A 132
GLN A 136
 None
 1.25A 3fzgA-4leuA:
undetectable		 3fzgA-4leuA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		5 HIS A 389
SER A 412
GLY A 390
ILE A 400
LEU A 368
 None
 1.29A 3fzgA-4n0rA:
undetectable		 3fzgA-4n0rA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7w TRANSPORTER,
SODIUM/BILE ACID
SYMPORTER FAMILY

(Yersinia
frederiksenii) 		PF01758
(SBF) 		5 GLY A 261
GLY A 279
ILE A 197
LEU A 266
VAL A  34
 CIT  A 401 (-3.5A)
None
CIT  A 401 (-3.8A)
None
None
 1.15A 3fzgA-4n7wA:
undetectable		 3fzgA-4n7wA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		5 HIS A 474
GLY A 619
GLY A 615
LEU A 587
GLN A 468
 None
 1.15A 3fzgA-4nh0A:
1.1		 3fzgA-4nh0A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 SER A 445
GLY A 427
GLY A 435
LEU A 441
GLN A 137
 None
 1.02A 3fzgA-4ohtA:
4.0		 3fzgA-4ohtA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxq D-GLUCURONYL C5
EPIMERASE B

(Danio rerio) 		PF06662
(C5-epim_C) 		5 HIS A 354
SER A 273
GLY A 249
LEU A 351
VAL A 288
 None
 1.21A 3fzgA-4pxqA:
undetectable		 3fzgA-4pxqA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Atopobium
parvulum) 		PF00905
(Transpeptidase) 		5 HIS A 801
SER A 803
GLY A 806
GLY A 799
VAL A 755
 None
 1.30A 3fzgA-4ra7A:
undetectable		 3fzgA-4ra7A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 SER A 241
THR A 240
GLY A 187
ILE A  68
LEU A 115
 None
 1.25A 3fzgA-4tmcA:
undetectable		 3fzgA-4tmcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 164
THR A 163
GLY A 232
GLY A 188
GLN A  81
 None
 1.20A 3fzgA-4xoxA:
undetectable		 3fzgA-4xoxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 SER A 164
THR A 163
GLY A 232
GLY A 188
LEU A 332
 None
 1.28A 3fzgA-4xoxA:
undetectable		 3fzgA-4xoxA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 SER A  96
GLY A 124
GLY A 122
ILE A 368
VAL A 128
 None
NDP  A 401 ( 4.0A)
AZI  A 402 (-3.6A)
None
None
 1.26A 3fzgA-4xybA:
3.7		 3fzgA-4xybA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt2 H(2)-FORMING
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE-RELATE
D PROTEIN MJ1338

(Methanocaldococcus
jannaschii) 		PF03201
(HMD) 		5 HIS A 155
SER A 153
THR A 126
PHE A 351
LEU A 134
 None
 1.19A 3fzgA-4yt2A:
undetectable		 3fzgA-4yt2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z26 PUTATIVE GMC-TYPE
OXIDOREDUCTASE R135

(Acanthamoeba
polyphaga
mimivirus) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 SER A 298
THR A 297
GLY A  97
GLY A  15
ILE A 104
 FAD  A 901 (-3.7A)
None
FAD  A 901 (-4.8A)
FAD  A 901 (-3.2A)
None
 1.26A 3fzgA-4z26A:
undetectable		 3fzgA-4z26A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 THR A  36
GLY A 104
ILE A  59
LEU A 200
VAL A 211
 FAD  A 601 (-3.0A)
None
None
None
None
 1.27A 3fzgA-5eb5A:
undetectable		 3fzgA-5eb5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Mycobacterium
tuberculosis) 		PF02776
(TPP_enzyme_N) 		5 THR A 300
GLY A 231
GLY A 233
LEU A 275
VAL A 307
 None
None
FMT  A 603 ( 4.7A)
None
None
 0.95A 3fzgA-5esoA:
undetectable		 3fzgA-5esoA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eut PHOSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA,ENDOLYSIN,PH
OSPHATIDYLINOSITOL
4-KINASE TYPE
2-ALPHA

(Homo sapiens;
Escherichia
virus T4) 		PF00454
(PI3_PI4_kinase)
PF00959
(Phage_lysozyme) 		5 HIS A 355
PHE A 351
ILE A 303
LEU A 353
LYS A 418
 None
 1.19A 3fzgA-5eutA:
undetectable		 3fzgA-5eutA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5n LH3
HEXON-INTERLACING
CAPSID PROTEIN

(Snake
atadenovirus A) 		PF01696
(Adeno_E1B_55K) 		5 GLY A 324
GLY A 318
LEU A 316
VAL A 350
GLN A 370
 None
 1.28A 3fzgA-5g5nA:
undetectable		 3fzgA-5g5nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22) 		no annotation 5 SER Y 198
GLY Y 301
LEU Y 279
LYS Y 229
VAL Y 204
 None
 1.22A 3fzgA-5gaiY:
undetectable		 3fzgA-5gaiY:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 THR A  39
PHE A 205
GLY A 206
ILE A 229
VAL A 250
 GDP  A 501 (-3.5A)
None
None
None
None
 0.99A 3fzgA-5h7kA:
undetectable		 3fzgA-5h7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 SER A 473
THR A 470
GLY A 503
GLY A 501
ILE A 299
 None
 1.29A 3fzgA-5jm0A:
undetectable		 3fzgA-5jm0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 223
GLY A  24
LYS A 313
VAL A 315
GLN A 317
 None
 1.23A 3fzgA-5k6oA:
undetectable		 3fzgA-5k6oA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oee LARGE SUBUNIT
TERMINASE

(Phage D6E) 		no annotation 5 THR A 198
PHE A  14
ILE A  49
LYS A  17
VAL A  21
 None
 1.28A 3fzgA-5oeeA:
undetectable		 3fzgA-5oeeA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B

(Homo sapiens) 		no annotation 5 GLY D 169
ILE D 348
LEU D 215
LYS D 212
MET D 214
 None
AGS  D 501 (-4.0A)
None
None
AGS  D 501 (-3.6A)
 1.14A 3fzgA-5vfrD:
undetectable		 3fzgA-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
D30 TCR BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968)
no annotation 		5 HIS D  40
SER D  33
GLY E 118
LEU E 116
GLN E  57
 None
 1.06A 3fzgA-5wkhD:
undetectable		 3fzgA-5wkhD:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxu 11S GLOBULIN

(Wrightia
tinctoria) 		no annotation 5 GLY A 363
GLY A 399
LEU A 338
VAL A 358
GLN A 384
 None
 1.23A 3fzgA-5wxuA:
undetectable		 3fzgA-5wxuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjm FABH

(Mus musculus) 		no annotation 5 THR H  28
GLY H  33
GLY H  31
ILE H  51
LEU H 100
 None
 1.30A 3fzgA-5xjmH:
undetectable		 3fzgA-5xjmH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 SER A 251
THR A 252
GLY A 346
GLY A 351
ILE A 361
 COA  A 402 (-2.2A)
None
None
None
None
 1.28A 3fzgA-6bjaA:
undetectable		 3fzgA-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0p PIRIN FAMILY PROTEIN

(Acinetobacter
baumannii) 		no annotation 5 HIS A  79
THR A  78
GLY A  85
GLY A  87
VAL A 103
 None
 1.29A 3fzgA-6d0pA:
undetectable		 3fzgA-6d0pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 GLY A 300
GLY A 296
ILE A 273
LEU A 302
VAL A 325
 None
 1.13A 3fzgA-6eu6A:
undetectable		 3fzgA-6eu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ft1 FLAVODOXIN

(Bacillus cereus) 		no annotation 5 PHE A 143
GLY A  56
ILE A  53
LEU A 122
VAL A 117
 None
 1.06A 3fzgA-6ft1A:
undetectable		 3fzgA-6ft1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6
NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 1

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		5 GLY J  45
LEU J 124
MET J 125
VAL J 128
GLN a  42
 None
 1.24A 3fzgA-6g2jJ:
undetectable		 3fzgA-6g2jJ:
undetectable