SIMILAR PATTERNS OF AMINO ACIDS FOR 3FXR_A_ASCA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		4 ALA A 137
ILE A 136
PRO A 131
PRO A 162
 None
 0.84A 3fxrA-1c8uA:
undetectable		 3fxrA-1c8uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF
PELLE

(Drosophila
melanogaster) 		PF00531
(Death) 		4 ARG A  35
ALA A  33
ILE A  34
ASN A  95
 None
 0.99A 3fxrA-1d2zA:
undetectable		 3fxrA-1d2zA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqz PROTEIN (ANTIGEN
85-C)

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 ALA A 185
ASN A 189
PRO A 153
PRO A 159
 None
 0.69A 3fxrA-1dqzA:
0.0		 3fxrA-1dqzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA

(Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		4 ALA A1082
ILE A1083
ASN A1024
PRO A1097
 None
 0.91A 3fxrA-1e6yA:
0.0		 3fxrA-1e6yA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 ALA A 187
ASN A 191
PRO A 155
PRO A 161
 None
 0.81A 3fxrA-1f0pA:
0.1		 3fxrA-1f0pA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTM, FLAVOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 HIS C 211
ARG C 213
ALA C 131
PRO C 173
 None
 0.99A 3fxrA-1ffvC:
0.0		 3fxrA-1ffvC:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gso PROTEIN (GLYCINAMIDE
RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 ALA A  31
ILE A   6
PRO A  72
PRO A  75
 None
 1.01A 3fxrA-1gsoA:
undetectable		 3fxrA-1gsoA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2a HYDROGENASE

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ALA S 144
ILE S 145
ASN S 146
PRO S 179
PRO S 171
 None
 1.35A 3fxrA-1h2aS:
undetectable		 3fxrA-1h2aS:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		4 ARG A  23
ALA A  24
ILE A  27
PRO A 214
 None
 0.91A 3fxrA-1hg3A:
0.0		 3fxrA-1hg3A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 4 ARG B 154
ALA B  98
ILE B  99
PRO B  52
 None
 0.99A 3fxrA-1jmzB:
undetectable		 3fxrA-1jmzB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jov HI1317

(Haemophilus
influenzae) 		PF01263
(Aldose_epim) 		4 ALA A  68
ILE A  93
ASN A  67
PRO A  86
 None
 0.88A 3fxrA-1jovA:
undetectable		 3fxrA-1jovA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		4 ALA A 187
ASN A 191
PRO A 155
PRO A 161
 None
 0.77A 3fxrA-1sfrA:
undetectable		 3fxrA-1sfrA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sky F1-ATPASE

(Bacillus sp.
PS3) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 ALA B 359
ILE B 357
ASN B 358
PRO B 355
 None
 1.00A 3fxrA-1skyB:
undetectable		 3fxrA-1skyB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 ALA A  83
ILE A  87
PRO A  63
PRO A 110
 None
 0.98A 3fxrA-1v6tA:
undetectable		 3fxrA-1v6tA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
gigas) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ALA A 142
ILE A 143
ASN A 144
PRO A 176
PRO A 168
 None
 1.27A 3fxrA-1yq9A:
undetectable		 3fxrA-1yq9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii) 		PF00235
(Profilin) 		4 ALA A  54
ILE A  55
ASN A  58
ARG A  66
 None
 0.99A 3fxrA-2acgA:
undetectable		 3fxrA-2acgA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ASN A 451
ARG A 476
PRO A 365
PRO A 443
 None
 0.95A 3fxrA-2b39A:
undetectable		 3fxrA-2b39A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b61 HOMOSERINE
O-ACETYLTRANSFERASE

(Haemophilus
influenzae) 		PF00561
(Abhydrolase_1) 		4 ALA A 176
ILE A 177
ASN A 180
ARG A 184
 None
 0.70A 3fxrA-2b61A:
undetectable		 3fxrA-2b61A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmh MYOFERLIN

(Homo sapiens) 		PF00168
(C2) 		4 ILE A  19
ASN A  50
PRO A  29
PRO A  27
 None
 0.83A 3fxrA-2dmhA:
undetectable		 3fxrA-2dmhA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ALA A 395
ILE A 396
ASN A 399
PRO A 410
 None
 0.51A 3fxrA-2dq3A:
undetectable		 3fxrA-2dq3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 ARG A 390
ALA A 275
ILE A 278
PRO A 285
 None
 0.89A 3fxrA-2f5uA:
undetectable		 3fxrA-2f5uA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		4 ALA A 179
ILE A 180
ASN A 148
PRO A 144
 None
 0.83A 3fxrA-2g6yA:
undetectable		 3fxrA-2g6yA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzg MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME/ENOLASE
SUPERFAMILY

(Rhodobacter
sphaeroides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 256
ILE A 281
ASN A 258
PRO A 286
 None
 0.95A 3fxrA-2hzgA:
undetectable		 3fxrA-2hzgA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5i UPF0249 PROTEIN
EF_3048

(Enterococcus
faecalis) 		PF04794
(YdjC) 		4 ALA A 255
ILE A   7
ASN A 256
PRO A 176
 None
 0.97A 3fxrA-2i5iA:
undetectable		 3fxrA-2i5iA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2krk 26S PROTEASE
REGULATORY SUBUNIT 8

(Homo sapiens) 		no annotation 4 HIS A   8
ALA A  48
ARG A  16
PRO A  11
 None
 0.97A 3fxrA-2krkA:
undetectable		 3fxrA-2krkA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 ARG A 192
ALA A 184
ILE A 181
PRO A 236
 None
 0.95A 3fxrA-2qagA:
undetectable		 3fxrA-2qagA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjw UNCHARACTERIZED
PROTEIN XCC1541

(Xanthomonas
campestris) 		no annotation 4 ARG A 144
ALA A 146
ILE A 123
PRO A 104
 None
 1.00A 3fxrA-2qjwA:
undetectable		 3fxrA-2qjwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xla SLL1785 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 ARG A 211
ALA A 102
ILE A 103
PRO A  73
 None
 0.88A 3fxrA-2xlaA:
undetectable		 3fxrA-2xlaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 ALA A 246
ILE A 249
ASN A 245
PRO A 637
 None
 1.01A 3fxrA-2yfsA:
undetectable		 3fxrA-2yfsA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 ALA A 146
ILE A 147
PRO A 153
PRO A  76
 None
 0.86A 3fxrA-2yx0A:
0.6		 3fxrA-2yx0A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1b DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Mus musculus) 		PF00490
(ALAD) 		4 ARG A 147
ALA A 177
ILE A 178
PRO A 167
 None
 0.90A 3fxrA-2z1bA:
undetectable		 3fxrA-2z1bA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2u UPF0026 PROTEIN
MJ0257

(Methanocaldococcus
jannaschii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 ALA A 132
ILE A 133
PRO A 139
PRO A  57
 None
 0.87A 3fxrA-2z2uA:
undetectable		 3fxrA-2z2uA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		4 ALA A 131
ILE A 130
ARG A 386
PRO A 392
 None
 1.03A 3fxrA-2zpaA:
undetectable		 3fxrA-2zpaA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr2 SERYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ALA A 416
ILE A 417
ASN A 420
PRO A 431
 None
 0.58A 3fxrA-2zr2A:
undetectable		 3fxrA-2zr2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ALA A 360
ILE A 358
ASN A 359
PRO A 143
 None
 0.99A 3fxrA-2zviA:
undetectable		 3fxrA-2zviA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ALA A 407
ILE A 406
ASN A 408
PRO A 127
 None
 1.02A 3fxrA-3c4qA:
undetectable		 3fxrA-3c4qA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5e PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE

(Homo sapiens) 		PF03403
(PAF-AH_p_II) 		4 ALA A 380
ILE A 381
ASN A 353
PRO A  57
 None
 0.90A 3fxrA-3d5eA:
undetectable		 3fxrA-3d5eA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dhv D-ALANINE-POLY(PHOSP
HORIBITOL) LIGASE

(Bacillus cereus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 HIS A  59
ALA A 215
ILE A 216
ASN A 190
 None
 1.02A 3fxrA-3dhvA:
undetectable		 3fxrA-3dhvA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euh CHROMOSOME PARTITION
PROTEIN MUKF
MUKE

(Escherichia
coli;
Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M)
PF17193
(MukF_C)
PF04288
(MukE) 		4 ALA A 320
ILE C  92
ASN A 319
PRO C  86
 None
 1.01A 3fxrA-3euhA:
4.5		 3fxrA-3euhA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		8 HIS A 150
ARG A 199
ALA A 203
ILE A 204
ASN A 207
ARG A 211
PRO A 266
PRO A 268
 CL  A4002 (-4.2A)
None
CL  A4002 ( 4.0A)
FMT  A3001 (-4.1A)
None
None
None
None
 0.54A 3fxrA-3fxqA:
35.9		 3fxrA-3fxqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fxq LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 HIS A 150
ARG A 199
ALA A 203
ILE A 204
PRO A 268
 CL  A4002 (-4.2A)
None
CL  A4002 ( 4.0A)
FMT  A3001 (-4.1A)
None
 1.50A 3fxrA-3fxqA:
35.9		 3fxrA-3fxqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnn NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Burkholderia
pseudomallei) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ALA A  24
ILE A  25
ASN A  28
PRO A  69
 None
 0.92A 3fxrA-3gnnA:
undetectable		 3fxrA-3gnnA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Herpetosiphon
aurantiacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  12
ILE A  13
ASN A  14
PRO A 331
 None
 1.00A 3fxrA-3ik4A:
undetectable		 3fxrA-3ik4A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 ALA A 145
ILE A 144
ARG A 119
PRO A 269
 None
 1.00A 3fxrA-3kgbA:
undetectable		 3fxrA-3kgbA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF03466
(LysR_substrate) 		6 HIS A 150
ARG A 199
ALA A 203
ARG A 211
PRO A 266
PRO A 268
 ACT  A1006 ( 3.4A)
None
ACT  A1006 ( 3.8A)
ACT  A1007 (-3.3A)
None
ACT  A1006 (-4.1A)
 1.21A 3fxrA-3n6uA:
22.3		 3fxrA-3n6uA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n6u LYSR TYPE REGULATOR
OF TSAMBCD

(Comamonas
testosteroni) 		PF03466
(LysR_substrate) 		6 HIS A 150
ARG A 199
ALA A 203
ILE A 204
PRO A 266
PRO A 268
 ACT  A1006 ( 3.4A)
None
ACT  A1006 ( 3.8A)
ACT  A1006 ( 4.0A)
None
ACT  A1006 (-4.1A)
 0.94A 3fxrA-3n6uA:
22.3		 3fxrA-3n6uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		4 HIS A 342
ILE A   2
PRO A 304
PRO A 340
 None
 1.00A 3fxrA-3nu8A:
undetectable		 3fxrA-3nu8A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 ALA A 216
ILE A 215
ASN A 217
PRO A 237
 None
 0.86A 3fxrA-3nzuA:
0.6		 3fxrA-3nzuA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqc PANTOTHENATE KINASE

(Coxiella
burnetii) 		PF00485
(PRK) 		4 ALA A 163
ILE A 164
PRO A  89
PRO A 194
 None
 0.89A 3fxrA-3tqcA:
undetectable		 3fxrA-3tqcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ALA A  84
ILE A  83
ASN A  86
PRO A  28
 None
 0.86A 3fxrA-3tx8A:
undetectable		 3fxrA-3tx8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6r ANTIBODY 1:7 (HEAVY
CHAIN)
ANTIBODY 1:7 (LIGHT
CHAIN)

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 ARG H 109
ILE H 108
ARG L 239
PRO H 105
 SO4  H 150 (-3.4A)
None
SO4  H 150 (-4.5A)
None
 1.00A 3fxrA-3u6rH:
undetectable		 3fxrA-3u6rH:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A

(Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 HIS A 424
ILE A 428
ASN A 429
PRO A 426
 None
 1.01A 3fxrA-3vr5A:
undetectable		 3fxrA-3vr5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej6 PUTATIVE
ZINC-BINDING
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 107
ILE A  86
ASN A  85
PRO A 123
 None
 0.74A 3fxrA-4ej6A:
undetectable		 3fxrA-4ej6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g5e 2,4,6-TRICHLOROPHENO
L 4-MONOOXYGENASE

(Cupriavidus
pinatubonensis) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 HIS A 290
ALA A 453
ILE A 454
ARG A 461
 None
 0.99A 3fxrA-4g5eA:
undetectable		 3fxrA-4g5eA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 ALA S 158
ILE S 159
PRO S 170
PRO S 178
 None
 0.87A 3fxrA-4gd3S:
undetectable		 3fxrA-4gd3S:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy3 PHOSPHOGLYCERATE
OXIDOREDUCTASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 ALA A  45
ILE A  44
ASN A  43
PRO A  62
 None
 0.94A 3fxrA-4hy3A:
undetectable		 3fxrA-4hy3A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krr WNT INHIBITOR OF
DORSAL PROTEIN

(Drosophila
melanogaster) 		PF00110
(wnt) 		4 ALA A 142
ILE A 143
ASN A 146
PRO A  74
 None
 0.95A 3fxrA-4krrA:
undetectable		 3fxrA-4krrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ALA A 439
ILE A 440
ASN A 443
PRO A 453
 None
 0.57A 3fxrA-4l87A:
2.2		 3fxrA-4l87A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ARG A 389
ALA A 387
ILE A 388
PRO A 340
 None
 0.96A 3fxrA-4lbwA:
1.3		 3fxrA-4lbwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2g L-ARGININE
BETA-HYDROXYLASE

(Streptomyces
lavendulae) 		PF02668
(TauD) 		4 HIS A 204
ARG A 237
ILE A 234
PRO A 207
 None
 0.86A 3fxrA-4m2gA:
undetectable		 3fxrA-4m2gA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9x CELL DEATH PROTEIN 4

(Caenorhabditis
elegans) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 ALA A  55
ILE A  54
ASN A  56
PRO A  23
 None
 0.97A 3fxrA-4m9xA:
1.9		 3fxrA-4m9xA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pts GLUTATHIONE
S-TRANSFERASE

(Gordonia
bronchialis) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ALA A 336
ARG A  49
PRO A 100
PRO A  95
 None
 0.95A 3fxrA-4ptsA:
undetectable		 3fxrA-4ptsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwu MODULATOR PROTEIN
MZRA

(Klebsiella
pneumoniae) 		PF13721
(SecD-TM1) 		4 ARG A  42
ALA A  40
ILE A  41
PRO A  51
 None
 0.80A 3fxrA-4pwuA:
undetectable		 3fxrA-4pwuA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 INTEGRIN BETA-4

(Homo sapiens) 		PF00041
(fn3) 		4 ARG C1301
ALA C1252
ILE C1250
PRO C1220
 None
 0.98A 3fxrA-4q58C:
undetectable		 3fxrA-4q58C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7q LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Chitinophaga
pinensis) 		PF13472
(Lipase_GDSL_2) 		4 ARG A  52
ALA A 264
ILE A 263
PRO A 255
 None
 0.66A 3fxrA-4q7qA:
undetectable		 3fxrA-4q7qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 ALA A1227
ILE A1309
ASN A1226
PRO A1106
 None
 0.89A 3fxrA-4r04A:
undetectable		 3fxrA-4r04A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tn9 COLLAGENASE

(Hathewaya
histolytica) 		PF00801
(PKD) 		4 ARG A 702
ALA A 739
ILE A 704
ASN A 703
 None
 1.02A 3fxrA-4tn9A:
undetectable		 3fxrA-4tn9A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 ALA S 144
ILE S 145
ASN S 146
PRO S 179
PRO S 171
 None
None
MPD  S2004 (-3.5A)
None
None
 1.36A 3fxrA-4u9iS:
undetectable		 3fxrA-4u9iS:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 334
ILE A 333
ASN A 336
PRO A 339
 None
 0.98A 3fxrA-4uekA:
undetectable		 3fxrA-4uekA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ukd URIDYLMONOPHOSPHATE/
CYTIDYLMONOPHOSPHATE
KINASE

(Dictyostelium
discoideum) 		PF00406
(ADK) 		4 ALA A  77
ILE A  78
ASN A  81
PRO A   6
 None
 0.87A 3fxrA-4ukdA:
undetectable		 3fxrA-4ukdA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8v CRISPR SYSTEM CMR
SUBUNIT CMR6

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 ALA A 245
ILE A 248
ASN A 138
PRO A 252
 None
 0.95A 3fxrA-4w8vA:
undetectable		 3fxrA-4w8vA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb0 BROAD SPECIFICITY
AMINOTRANSFERASE

(Leishmania
mexicana) 		PF00155
(Aminotran_1_2) 		4 ALA A 208
ILE A 207
ASN A 205
PRO A 199
 None
 1.02A 3fxrA-4wb0A:
undetectable		 3fxrA-4wb0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgj BEPC PROTEIN

(Bartonella
tribocorum) 		PF02661
(Fic) 		4 HIS A 144
ILE A 102
ARG A  74
PRO A  99
 None
 0.71A 3fxrA-4wgjA:
undetectable		 3fxrA-4wgjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 189
ILE A 190
ARG A  11
PRO A 219
 None
None
None
GOL  A 502 (-4.2A)
 0.99A 3fxrA-4wyrA:
undetectable		 3fxrA-4wyrA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE

(Homo sapiens) 		PF05889
(SepSecS) 		4 ARG A  90
ALA A  59
ILE A  60
ASN A  65
 None
 1.00A 3fxrA-4zdlA:
undetectable		 3fxrA-4zdlA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ALA S 158
ILE S 159
PRO S 170
PRO S 178
 None
 0.81A 3fxrA-5a4mS:
undetectable		 3fxrA-5a4mS:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		4 ALA A 305
ILE A 307
ASN A 306
PRO A 252
 None
 0.93A 3fxrA-5bt8A:
undetectable		 3fxrA-5bt8A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5duy GALNAC/GAL-SPECIFIC
LECTIN

(Crenomytilus
grayanus) 		no annotation 4 HIS A  37
ARG A  39
ALA A  58
PRO A  17
 GOL  A 201 (-4.1A)
None
None
None
 1.02A 3fxrA-5duyA:
undetectable		 3fxrA-5duyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 ARG A 168
ALA A  42
ILE A  45
PRO A 178
 ARG  A 168 ( 0.6A)
ALA  A  42 ( 0.0A)
ILE  A  45 ( 0.7A)
PRO  A 178 ( 1.1A)
 1.03A 3fxrA-5ep8A:
undetectable		 3fxrA-5ep8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f15 4-AMINO-4-DEOXY-L-AR
ABINOSE (L-ARA4N)
TRANSFERASE

(Cupriavidus
metallidurans) 		PF13231
(PMT_2) 		4 HIS A 454
ALA A 395
ILE A 398
ASN A 396
 CL  A 680 (-3.9A)
MPG  A 675 ( 4.0A)
None
None
 0.96A 3fxrA-5f15A:
undetectable		 3fxrA-5f15A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fir 5'-3'
EXORIBONUCLEASE 2
HOMOLOG

(Caenorhabditis
elegans) 		PF03159
(XRN_N) 		4 ALA A 190
ILE A 192
ASN A 191
PRO A  94
 None
 0.94A 3fxrA-5firA:
undetectable		 3fxrA-5firA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 ARG A 346
ILE A 348
PRO A  58
PRO A  71
 GOL  A 403 (-2.7A)
None
None
None
 0.99A 3fxrA-5gllA:
undetectable		 3fxrA-5gllA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmx CARBOXYLESTERASE

(uncultured
bacterium) 		PF00144
(Beta-lactamase) 		4 ARG A 273
ALA A 197
ASN A 199
ARG A 212
 None
 0.99A 3fxrA-5gmxA:
undetectable		 3fxrA-5gmxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 ALA B 298
ILE B 299
ASN B 276
PRO B 325
 None
 0.64A 3fxrA-5gq0B:
undetectable		 3fxrA-5gq0B:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ALA A 122
ILE A 126
PRO A  47
PRO A 174
 None
 0.97A 3fxrA-5gzyA:
undetectable		 3fxrA-5gzyA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd3 LAE5

(uncultured
bacterium) 		PF13472
(Lipase_GDSL_2) 		4 ALA A 205
ILE A 204
ASN A 206
PRO A 196
 None
 1.01A 3fxrA-5jd3A:
1.7		 3fxrA-5jd3A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko9 EMBRYONIC STEM
CELL-SPECIFIC
5-HYDROXYMETHYLCYTOS
INE-BINDING PROTEIN

(Homo sapiens) 		PF02586
(SRAP) 		4 ARG A  33
ALA A  71
ILE A  70
PRO A  30
 None
 0.98A 3fxrA-5ko9A:
undetectable		 3fxrA-5ko9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li8 PUTATIVE CYTOCHROME
P450 126

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ALA A 263
ILE A 262
ASN A 260
PRO A 154
 None
 1.02A 3fxrA-5li8A:
undetectable		 3fxrA-5li8A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 ALA K 428
ILE K 430
ASN K 429
PRO K 105
 None
 0.97A 3fxrA-5mm7K:
undetectable		 3fxrA-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 4 ALA A1531
ILE A1530
ASN A1529
PRO A1786
 None
 0.91A 3fxrA-5nnlA:
undetectable		 3fxrA-5nnlA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 ALA A 150
ILE A 161
ASN A 164
PRO A  97
 None
 0.97A 3fxrA-5ol0A:
undetectable		 3fxrA-5ol0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA

(Neurospora
crassa) 		no annotation 4 ALA B 376
ILE B 378
ASN B 377
PRO B 381
 None
 0.99A 3fxrA-5vqiB:
undetectable		 3fxrA-5vqiB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 ALA A 179
ILE A 178
ARG A 362
PRO A 187
 None
 0.98A 3fxrA-5w6mA:
undetectable		 3fxrA-5w6mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 4 HIS A 426
ILE A 430
ASN A 431
PRO A 428
 None
 0.99A 3fxrA-5x09A:
undetectable		 3fxrA-5x09A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 HIS A 196
ALA A  65
ILE A  66
ASN A  69
 None
 0.98A 3fxrA-5x62A:
undetectable		 3fxrA-5x62A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xg5 MITSUBA-1

(synthetic
construct) 		PF14200
(RicinB_lectin_2) 		4 HIS A 133
ARG A 135
ALA A  10
PRO A 113
 A2G  A 203 (-4.0A)
None
None
None
 1.00A 3fxrA-5xg5A:
undetectable		 3fxrA-5xg5A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnz CRED

(Streptomyces
cremeus) 		no annotation 4 ALA A 367
ASN A 368
ARG A 152
PRO A 148
 None
 0.95A 3fxrA-5xnzA:
1.3		 3fxrA-5xnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 4 ALA C 217
ILE C 216
PRO C  59
PRO C  62
 None
 0.97A 3fxrA-5y6qC:
undetectable		 3fxrA-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 ALA A 227
ILE A 228
PRO A 355
PRO A 358
 GOL  A 502 (-3.5A)
None
None
None
 0.94A 3fxrA-6c4rA:
undetectable		 3fxrA-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 4 HIS A  48
ARG A 242
ALA A 240
PRO A 320
 None
FAD  A 601 ( 4.8A)
None
FAD  A 601 (-4.8A)
 1.03A 3fxrA-6em0A:
undetectable		 3fxrA-6em0A:
undetectable