SIMILAR PATTERNS OF AMINO ACIDS FOR 3FW3_A_ETSA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		5 HIS C 323
ILE C 522
LEU C 369
THR C 370
THR C 371
 None
 0.97A 3fw3A-1j3jC:
0.0		 3fw3A-1j3jC:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.26A 3fw3A-1jd0A:
33.1		 3fw3A-1jd0A:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 1.37A 3fw3A-1jd0A:
33.1		 3fw3A-1jd0A:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
 1.43A 3fw3A-1jd0A:
33.1		 3fw3A-1jd0A:
35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		11 ASN A  64
HIS A  66
GLN A  90
HIS A  92
HIS A  94
VAL A 113
VAL A 123
LEU A 176
THR A 177
THR A 178
TRP A 187
 BME  A 303 (-4.7A)
BME  A 303 (-3.6A)
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
None
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.48A 3fw3A-1kopA:
27.5		 3fw3A-1kopA:
33.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 HIS A  66
GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
 BME  A 303 (-3.6A)
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.00A 3fw3A-1kopA:
27.5		 3fw3A-1kopA:
33.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  66
GLN A  69
HIS A  94
VAL A 113
LEU A 176
THR A 178
 BME  A 303 (-3.6A)
None
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 ( 4.2A)
 1.38A 3fw3A-1kopA:
27.5		 3fw3A-1kopA:
33.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 HIS A  66
HIS A  94
LEU A 176
THR A 177
THR A 178
TRP A 187
 BME  A 303 (-3.6A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 1.35A 3fw3A-1kopA:
27.5		 3fw3A-1kopA:
33.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.69A 3fw3A-1rj6A:
34.1		 3fw3A-1rj6A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  64
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 0.90A 3fw3A-1rj6A:
34.1		 3fw3A-1rj6A:
35.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 HIS A  64
GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 None
None
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.12A 3fw3A-1rj6A:
34.1		 3fw3A-1rj6A:
35.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 VAL A  56
ILE A   6
VAL A   8
LEU A  24
THR A  23
 None
 0.79A 3fw3A-1u3iA:
0.0		 3fw3A-1u3iA:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
None
None
 0.39A 3fw3A-1urtA:
29.9		 3fw3A-1urtA:
32.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
 1.36A 3fw3A-1urtA:
29.9		 3fw3A-1urtA:
32.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 HIS A 130
VAL A 266
ILE A 288
VAL A 286
THR A 148
 None
 0.73A 3fw3A-1vknA:
0.0		 3fw3A-1vknA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF00400
(WD40) 		5 HIS C 275
ILE C 353
VAL C 344
LEU C 334
THR C 333
 None
 0.95A 3fw3A-1vyhC:
0.0		 3fw3A-1vyhC:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		9 GLN A 113
HIS A 115
HIS A 117
VAL A 137
VAL A 153
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.34A 3fw3A-1y7wA:
23.6		 3fw3A-1y7wA:
28.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		5 HIS A  18
ILE A 228
LEU A  66
THR A  67
THR A  68
 None
 0.88A 3fw3A-2aazA:
undetectable		 3fw3A-2aazA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
 None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.48A 3fw3A-2it4A:
31.3		 3fw3A-2it4A:
31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 HIS A 235
ILE A 435
LEU A 281
THR A 282
THR A 283
 None
 0.88A 3fw3A-2oipA:
undetectable		 3fw3A-2oipA:
19.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  87
HIS A 118
ILE A 163
LEU A 222
THR A 223
TRP A 233
 None
CL  A 401 (-4.2A)
None
None
CL  A 401 ( 4.8A)
None
 0.51A 3fw3A-2w2jA:
32.6		 3fw3A-2w2jA:
31.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A 274
ILE A 276
VAL A 225
LEU A  83
THR A  84
 None
 0.94A 3fw3A-2xf2A:
undetectable		 3fw3A-2xf2A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmr PROTEIN NDRG2

(Homo sapiens) 		PF03096
(Ndr) 		5 VAL A 129
ILE A 155
VAL A 153
LEU A 289
THR A 290
 None
 0.91A 3fw3A-2xmrA:
undetectable		 3fw3A-2xmrA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 HIS A 220
ILE A 277
VAL A 268
LEU A 258
THR A 257
 None
 0.97A 3fw3A-2ymuA:
undetectable		 3fw3A-2ymuA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 HIS A 261
ILE A  31
VAL A  22
LEU A 299
THR A 298
 None
 0.95A 3fw3A-2ymuA:
undetectable		 3fw3A-2ymuA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 HIS A 466
ILE A 523
VAL A 514
LEU A 504
THR A 503
 None
 0.99A 3fw3A-2ymuA:
undetectable		 3fw3A-2ymuA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 HIS A 507
ILE A 564
VAL A 555
LEU A 545
THR A 544
 None
 0.92A 3fw3A-2ymuA:
undetectable		 3fw3A-2ymuA:
17.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
None
ZN  A   1 ( 4.7A)
None
None
 0.40A 3fw3A-2zncA:
40.7		 3fw3A-2zncA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
None
 1.27A 3fw3A-2zncA:
40.7		 3fw3A-2zncA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
None
ZN  A   1 ( 4.7A)
None
None
 1.35A 3fw3A-2zncA:
40.7		 3fw3A-2zncA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 1.36A 3fw3A-2zncA:
40.7		 3fw3A-2zncA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		11 ASN A 110
HIS A 112
GLN A 161
HIS A 163
HIS A 165
VAL A 184
VAL A 201
LEU A 259
THR A 260
THR A 261
TRP A 270
 None
None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
None
ZN  A 378 ( 4.5A)
None
None
 0.50A 3fw3A-3b1bA:
24.0		 3fw3A-3b1bA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
GLN A 115
HIS A 163
HIS A 165
THR A 260
THR A 261
 None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
None
 0.96A 3fw3A-3b1bA:
24.0		 3fw3A-3b1bA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
GLN A 115
HIS A 165
VAL A 184
THR A 260
THR A 261
 None
None
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
 1.22A 3fw3A-3b1bA:
24.0		 3fw3A-3b1bA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 112
HIS A 165
VAL A 184
LEU A 259
THR A 260
THR A 261
 None
ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
 1.05A 3fw3A-3b1bA:
24.0		 3fw3A-3b1bA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 HIS A 109
VAL A   3
ILE A  40
VAL A  42
THR A  31
 None
 0.91A 3fw3A-3c4qA:
undetectable		 3fw3A-3c4qA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 HIS A  65
GLN A  93
HIS A  95
HIS A  97
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.68A 3fw3A-3da2A:
32.1		 3fw3A-3da2A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 ASN A  83
HIS A  85
GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
 None
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
None
 0.73A 3fw3A-3fe4A:
30.6		 3fw3A-3fe4A:
32.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		5 HIS A   7
ILE A 206
LEU A  54
THR A  55
THR A  56
 None
 0.93A 3fw3A-3kgbA:
undetectable		 3fw3A-3kgbA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxp ALPHA-(N-ACETYLAMINO
METHYLENE)SUCCINIC
ACID HYDROLASE

(Mesorhizobium
loti) 		PF12697
(Abhydrolase_6) 		5 VAL A  26
ILE A  62
VAL A  64
LEU A  95
THR A  94
 None
 0.72A 3fw3A-3kxpA:
undetectable		 3fw3A-3kxpA:
24.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.44A 3fw3A-3ml5A:
32.7		 3fw3A-3ml5A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A   2
GLN A  92
VAL A 121
VAL A 143
LEU A 198
THR A 200
TRP A 209
 None
AZM  A 264 (-4.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.47A 3fw3A-3ml5A:
32.7		 3fw3A-3ml5A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
GLN A  67
HIS A  94
HIS A  96
THR A 199
THR A 200
 None
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 1.00A 3fw3A-3ml5A:
32.7		 3fw3A-3ml5A:
34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		9 GLN A 121
HIS A 123
HIS A 125
VAL A 144
VAL A 154
LEU A 214
THR A 215
THR A 216
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.48A 3fw3A-3q31A:
24.4		 3fw3A-3q31A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 HIS A 123
VAL A 154
LEU A 214
THR A 215
THR A 216
TRP A 225
 ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 1.31A 3fw3A-3q31A:
24.4		 3fw3A-3q31A:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
ILE A 140
VAL A 142
THR A 198
THR A 199
TRP A 208
 None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
None
ZN  A 261 ( 4.4A)
None
None
 0.68A 3fw3A-3uyqA:
32.7		 3fw3A-3uyqA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  62
HIS A  64
HIS A  96
ILE A 140
VAL A 121
THR A 199
 None
None
ZN  A 261 (-3.3A)
None
None
None
 1.47A 3fw3A-3uyqA:
32.7		 3fw3A-3uyqA:
34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
ILE A 140
THR A 198
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
 1.45A 3fw3A-3uyqA:
32.7		 3fw3A-3uyqA:
34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 HIS A 264
VAL A 246
ILE A 280
LEU A 308
THR A 304
 HIS  A 264 ( 1.0A)
VAL  A 246 ( 0.6A)
ILE  A 280 ( 0.7A)
LEU  A 308 ( 0.6A)
THR  A 304 ( 0.8A)
 0.95A 3fw3A-3whlA:
undetectable		 3fw3A-3whlA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzi UNCHARACTERIZED
PROTEIN AF_1864

(Archaeoglobus
fulgidus) 		PF09620
(Cas_csx3) 		5 GLN A  78
HIS A  61
VAL A  65
ILE A  43
VAL A  41
 None
 0.89A 3fw3A-3wziA:
undetectable		 3fw3A-3wziA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgv MALATE DEHYDROGENASE

(Picrophilus
torridus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  81
ILE A   6
VAL A   8
LEU A  22
THR A  21
 None
 0.87A 3fw3A-4bgvA:
undetectable		 3fw3A-4bgvA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 VAL A   9
ILE A 169
VAL A 167
LEU A 218
TRP A 187
 None
 0.95A 3fw3A-4eelA:
undetectable		 3fw3A-4eelA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		12 ASN A  62
HIS A  64
GLN A  87
HIS A  89
HIS A  91
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
None
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
None
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.53A 3fw3A-4g7aA:
28.3		 3fw3A-4g7aA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 GLN A  87
HIS A  89
HIS A  91
VAL A 110
ILE A 118
LEU A 173
THR A 175
 AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
None
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 1.39A 3fw3A-4g7aA:
28.3		 3fw3A-4g7aA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
GLN A  67
HIS A  89
HIS A  91
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 0.97A 3fw3A-4g7aA:
28.3		 3fw3A-4g7aA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
HIS A  91
ILE A 118
VAL A 110
LEU A 173
THR A 175
 None
ZN  A 301 ( 3.2A)
None
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
 1.31A 3fw3A-4g7aA:
28.3		 3fw3A-4g7aA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 VAL A 516
ILE A 467
VAL A 469
LEU A 499
TRP A 480
 None
 0.90A 3fw3A-4kkdA:
undetectable		 3fw3A-4kkdA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmp ALANINE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 HIS A 257
VAL A 235
ILE A 174
VAL A 172
LEU A 225
 None
 0.69A 3fw3A-4lmpA:
undetectable		 3fw3A-4lmpA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
 0.43A 3fw3A-4qk3A:
31.9		 3fw3A-4qk3A:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
 0.96A 3fw3A-4qk3A:
31.9		 3fw3A-4qk3A:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twl DIOSCORIN 5

(Dioscorea
japonica) 		PF00194
(Carb_anhydrase) 		5 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3fw3A-4twlA:
27.0		 3fw3A-4twlA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		11 ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
ILE A 141
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.45A 3fw3A-4uovA:
28.5		 3fw3A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 HIS A 114
ILE A 141
VAL A 133
LEU A 197
THR A 198
THR A 199
 ZN  A 298 ( 3.2A)
None
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
 1.33A 3fw3A-4uovA:
28.5		 3fw3A-4uovA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.47A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
HIS A  89
HIS A  91
VAL A 110
ILE A 118
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
PE8  A 303 (-4.9A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.41A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 HIS A  64
GLN A  67
HIS A  89
HIS A  91
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 0.95A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 HIS A  64
GLN A  67
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.25A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 HIS A  64
HIS A  91
ILE A 118
VAL A 110
LEU A 173
THR A 174
THR A 175
 None
ZN  A 301 ( 3.2A)
PE8  A 303 (-4.9A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.28A 3fw3A-4x5sA:
28.3		 3fw3A-4x5sA:
32.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		8 HIS A  84
HIS A 110
HIS A 112
VAL A 131
VAL A 141
LEU A 190
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
None
ZN  A 301 (-4.3A)
None
 1.00A 3fw3A-4xfwA:
25.5		 3fw3A-4xfwA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A  85
HIS A 110
HIS A 112
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-4.3A)
None
 0.95A 3fw3A-4xfwA:
25.5		 3fw3A-4xfwA:
28.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 HIS A 134
GLN A 138
HIS A 160
HIS A 162
LEU A 253
THR A 254
THR A 255
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
 0.96A 3fw3A-4xixA:
26.2		 3fw3A-4xixA:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 134
GLN A 138
HIS A 162
VAL A 181
LEU A 253
THR A 255
 None
None
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
 1.25A 3fw3A-4xixA:
26.2		 3fw3A-4xixA:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		10 HIS A 134
GLN A 158
HIS A 160
HIS A 162
VAL A 181
VAL A 192
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.54A 3fw3A-4xixA:
26.2		 3fw3A-4xixA:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 HIS A 134
HIS A 160
VAL A 192
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.45A 3fw3A-4xixA:
26.2		 3fw3A-4xixA:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		11 ASN A 138
HIS A 140
GLN A 163
HIS A 165
HIS A 167
VAL A 186
VAL A 196
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.46A 3fw3A-4xz5A:
27.5		 3fw3A-4xz5A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 140
GLN A 143
HIS A 165
HIS A 167
THR A 252
THR A 253
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.05A 3fw3A-4xz5A:
27.5		 3fw3A-4xz5A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 HIS A 140
HIS A 165
VAL A 196
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.2A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.47A 3fw3A-4xz5A:
27.5		 3fw3A-4xz5A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 HIS A 184
HIS A 167
VAL A 196
LEU A 251
THR A 252
THR A 253
 ZN  A 401 ( 3.1A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.42A 3fw3A-4xz5A:
27.5		 3fw3A-4xz5A:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 GOL  A 303 (-3.9A)
None
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.49A 3fw3A-5cjfA:
34.2		 3fw3A-5cjfA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
GLN A  67
HIS A  94
HIS A  96
THR A 199
THR A 200
 None
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 0.93A 3fw3A-5cjfA:
34.2		 3fw3A-5cjfA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 0.97A 3fw3A-5cjfA:
34.2		 3fw3A-5cjfA:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A 151
ILE A 197
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.49A 3fw3A-5e5uA:
33.1		 3fw3A-5e5uA:
31.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		11 ASN X  61
HIS X  63
GLN X  91
HIS X  93
HIS X  95
VAL X 120
VAL X 141
LEU X 196
THR X 197
THR X 198
TRP X 207
 None
None
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
None
None
 0.58A 3fw3A-5eztX:
32.5		 3fw3A-5eztX:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 ASN X  66
HIS X  95
VAL X 141
LEU X 196
THR X 198
 None
ZN  X 301 (-3.2A)
None
None
None
 0.95A 3fw3A-5eztX:
32.5		 3fw3A-5eztX:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo3 CELL DIVISION
PROTEIN ZAPC

(Escherichia
coli) 		PF07126
(ZapC) 		6 GLN A 142
VAL A 145
ILE A 147
VAL A 146
LEU A 117
THR A 120
 None
 1.18A 3fw3A-5fo3A:
undetectable		 3fw3A-5fo3A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		11 ASN A  69
HIS A  71
GLN A  94
HIS A  96
HIS A  98
VAL A 117
VAL A 127
LEU A 181
THR A 182
THR A 183
TRP A 192
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
 0.58A 3fw3A-5hpjA:
27.5		 3fw3A-5hpjA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 HIS A  71
HIS A  98
VAL A 117
LEU A 181
THR A 182
THR A 183
 None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
 1.21A 3fw3A-5hpjA:
27.5		 3fw3A-5hpjA:
31.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
ILE A 141
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
None
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.35A 3fw3A-5jn9A:
43.3		 3fw3A-5jn9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
ILE A 141
LEU A 198
THR A 199
 EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
None
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
 1.48A 3fw3A-5jn9A:
43.3		 3fw3A-5jn9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A  64
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.75A 3fw3A-5jn9A:
43.3		 3fw3A-5jn9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 VAL A  42
ILE A 134
VAL A 132
LEU A 215
THR A 216
 None
 0.97A 3fw3A-5k6oA:
undetectable		 3fw3A-5k6oA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 5 HIS A 169
VAL A  52
ILE A  36
VAL A  34
LEU A  21
 None
 0.81A 3fw3A-6ejjA:
undetectable		 3fw3A-6ejjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 10 ASN A  90
GLN A 115
HIS A 117
HIS A 119
VAL A 138
VAL A 148
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
ZN  A 301 (-4.4A)
None
None
 0.55A 3fw3A-6ekiA:
27.0		 3fw3A-6ekiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 10 ASN A  90
HIS A  92
HIS A 117
HIS A 119
VAL A 138
VAL A 148
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
ZN  A 301 (-4.4A)
None
None
 0.50A 3fw3A-6ekiA:
27.0		 3fw3A-6ekiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A  92
HIS A 119
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
None
ZN  A 301 (-4.4A)
None
None
 1.34A 3fw3A-6ekiA:
27.0		 3fw3A-6ekiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 HIS A  92
HIS A 119
VAL A 138
LEU A 201
THR A 202
THR A 203
 None
ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
None
 1.04A 3fw3A-6ekiA:
27.0		 3fw3A-6ekiA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 11 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
 V14  A 302 (-3.4A)
None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.42A 3fw3A-6fe1A:
33.1		 3fw3A-6fe1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 HIS A  64
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.27A 3fw3A-6fe1A:
33.1		 3fw3A-6fe1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
 0.86A 3fw3A-6fe1A:
33.1		 3fw3A-6fe1A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g72 NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 2,
MITOCHONDRIAL

(Mus musculus) 		no annotation 5 VAL E 154
ILE E 100
VAL E 102
LEU E 120
THR E 119
 None
 0.85A 3fw3A-6g72E:
undetectable		 3fw3A-6g72E:
14.96