SIMILAR PATTERNS OF AMINO ACIDS FOR 3FUP_B_MI1B1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  70
GLY A  71
VAL A  78
ALA A  91
LYS A  93
VAL A 118
MET A 138
LEU A 141
ASP A 207
 STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
STU  A 401 (-4.7A)
STU  A 401 (-3.4A)
STU  A 401 ( 4.5A)
None
STU  A 401 (-3.2A)
STU  A 401 (-3.9A)
STU  A 401 (-3.6A)
 0.58A 3fupB-1nxkA:
21.6		 3fupB-1nxkA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
GLY A 165
GLY A 167
VAL A 172
ALA A 185
LYS A 187
LEU A 249
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.0A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.7A)
 0.71A 3fupB-1q8yA:
23.1		 3fupB-1q8yA:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
VAL A 675
TYR A 693
LEU A 818
 None
 0.53A 3fupB-1rjbA:
27.7		 3fupB-1rjbA:
31.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
LYS A 623
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.47A 3fupB-1t46A:
23.8		 3fupB-1t46A:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
GLY A 596
VAL A 603
ALA A 621
VAL A 654
TYR A 672
LEU A 799
 STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-4.3A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
 0.41A 3fupB-1t46A:
23.8		 3fupB-1t46A:
34.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
VAL A 399
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.3A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.51A 3fupB-1u59A:
33.4		 3fupB-1u59A:
35.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 None
 0.46A 3fupB-1u5qA:
25.3		 3fupB-1u5qA:
29.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
VAL A  68
TYR A  86
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
 0.49A 3fupB-1zltA:
14.6		 3fupB-1zltA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
TYR A  86
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
 0.48A 3fupB-1zltA:
14.6		 3fupB-1zltA:
27.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 605
GLY A 606
GLY A 608
VAL A 613
ALA A 626
LYS A 628
MET A 788
TYR A 790
 None
None
None
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 ( 4.2A)
GOL  A 998 (-4.6A)
 0.71A 3fupB-1zy4A:
21.5		 3fupB-1zy4A:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
GLY X  18
GLY X  20
VAL X  25
ALA X  37
LYS X  39
VAL X  67
TYR X  84
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.56A 3fupB-2dq7X:
32.7		 3fupB-2dq7X:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
GLY X  18
GLY X  20
VAL X  25
LYS X  39
VAL X  67
TYR X  84
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
None
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.74A 3fupB-2dq7X:
32.7		 3fupB-2dq7X:
32.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
MET A 105
TYR A 107
LEU A 158
 STU  A 400 (-3.3A)
None
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
STU  A 400 ( 3.7A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.52A 3fupB-2gcdA:
26.2		 3fupB-2gcdA:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
GLY A 249
GLY A 251
VAL A 256
ALA A 269
LYS A 271
VAL A 299
LEU A 370
 GIN  A 600 ( 4.6A)
None
None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
GIN  A 600 (-4.7A)
 0.49A 3fupB-2hz0A:
32.0		 3fupB-2hz0A:
36.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 GLY A 429
VAL A 436
ALA A 452
LYS A 454
VAL A 484
MET A 499
LEU A 553
 4ST  A1687 (-3.1A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
None
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.53A 3fupB-2j0jA:
31.7		 3fupB-2j0jA:
19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
GLY A 589
VAL A 596
ALA A 614
VAL A 647
TYR A 665
LEU A 785
 None
 0.50A 3fupB-2ogvA:
28.0		 3fupB-2ogvA:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
GLY A  26
GLY A  28
VAL A  33
ALA A  46
LYS A  48
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.0A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
ATP  A 381 ( 4.8A)
 0.43A 3fupB-2phkA:
26.3		 3fupB-2phkA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  52
GLY A  53
GLY A  55
VAL A  60
ALA A  73
LYS A  75
LEU A 171
 DKI  A1338 (-3.8A)
DKI  A1338 (-3.3A)
None
DKI  A1338 (-4.2A)
DKI  A1338 ( 3.7A)
None
DKI  A1338 (-4.9A)
 0.53A 3fupB-2w4oA:
21.3		 3fupB-2w4oA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 144
LEU A 194
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 (-4.0A)
STU  A   1 (-4.6A)
 0.47A 3fupB-2z7rA:
22.5		 3fupB-2z7rA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
VAL A 125
LEU A 144
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-4.0A)
 0.46A 3fupB-2z7rA:
22.5		 3fupB-2z7rA:
28.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  97
GLY A  98
GLY A 100
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
None
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
 0.49A 3fupB-3a62A:
22.7		 3fupB-3a62A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  97
GLY A  98
VAL A 105
ALA A 121
LYS A 123
VAL A 156
TYR A 174
LEU A 175
 STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
None
STU  A 400 (-4.7A)
STU  A 400 (-3.8A)
 0.56A 3fupB-3a62A:
22.7		 3fupB-3a62A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
GLY A  18
ALA A  36
LYS A  38
MET A 117
TYR A 119
ASP A 185
 DRK  A 384 (-3.8A)
DRK  A 384 ( 4.4A)
None
DRK  A 384 (-3.5A)
None
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
DRK  A 384 ( 4.7A)
 0.81A 3fupB-3eb0A:
23.7		 3fupB-3eb0A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  59
GLY A  60
GLY A  62
VAL A  67
ALA A  80
LYS A  82
VAL A 113
MET A 129
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
STU  A   1 ( 3.8A)
STU  A   1 (-4.4A)
 0.56A 3fupB-3fmeA:
21.5		 3fupB-3fmeA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 210
GLY A 212
VAL A 217
ALA A 228
LYS A 230
MET A 279
TYR A 281
 ADP  A 900 (-3.4A)
ADP  A 900 (-3.0A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 (-3.6A)
None
 0.53A 3fupB-3g2fA:
27.2		 3fupB-3g2fA:
26.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
GLY A 834
VAL A 841
ALA A 859
VAL A 892
TYR A 911
LEU A1029
 8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.9A)
None
 0.52A 3fupB-3hngA:
29.1		 3fupB-3hngA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  82
GLY A  83
VAL A  90
ALA A 103
LYS A 105
MET A 153
ASP A 220
 J60  A 540 (-3.8A)
J60  A 540 ( 4.3A)
None
J60  A 540 (-3.6A)
GOL  A   1 (-2.7A)
GOL  A   1 ( 3.0A)
J60  A 540 ( 3.6A)
 0.44A 3fupB-3hztA:
19.5		 3fupB-3hztA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 432
GLY A 433
GLY A 435
ALA A 453
LYS A 455
VAL A 482
MET A 498
LEU A 501
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.6A)
ANP  A 400 ( 4.3A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.0A)
 0.61A 3fupB-3kn5A:
21.2		 3fupB-3kn5A:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 171
GLY A 172
GLY A 174
VAL A 179
ALA A 192
VAL A 224
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
None
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.60A 3fupB-3mtlA:
22.3		 3fupB-3mtlA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 171
VAL A 179
ALA A 192
LYS A 194
VAL A 224
TYR A 242
LEU A 243
LEU A 293
 FEF  A 668 ( 3.8A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
None
FEF  A 668 (-4.7A)
FEF  A 668 (-4.7A)
FEF  A 668 (-4.3A)
FEF  A 668 (-4.2A)
 0.75A 3fupB-3mtlA:
22.3		 3fupB-3mtlA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
TYR A 122
LEU A 173
ASP A 184
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
None
 0.64A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
ASP A 184
 XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
None
 0.52A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
TYR A 122
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.50A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  49
GLY A  50
GLY A  52
VAL A  57
ALA A  70
LYS A  72
VAL A 104
MET A 120
TYR A 122
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
None
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 ( 4.0A)
None
 0.46A 3fupB-3mvjA:
25.1		 3fupB-3mvjA:
23.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.40A 3fupB-3pp0A:
33.9		 3fupB-3pp0A:
32.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 GLY A 558
GLY A 560
ALA A 576
LYS A 578
VAL A 609
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.54A 3fupB-3ppzA:
30.2		 3fupB-3ppzA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 GLY A 558
GLY A 560
VAL A 565
ALA A 576
LYS A 578
TYR A 627
LEU A 628
LEU A 683
 STU  A   1 (-3.2A)
None
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.4A)
STU  A   1 (-4.5A)
STU  A   1 (-4.3A)
 0.61A 3fupB-3ppzA:
30.2		 3fupB-3ppzA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		8 LEU A  21
GLY A  22
VAL A  29
ALA A  42
LYS A  44
VAL A  74
MET A  96
TYR A  98
 None
 0.69A 3fupB-3qa8A:
20.2		 3fupB-3qa8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
GLY A  51
VAL A  58
ALA A  71
LYS A  73
VAL A  98
MET A 118
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.5A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 ( 3.9A)
None
 0.62A 3fupB-3sheA:
20.3		 3fupB-3sheA:
26.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
GLY A 424
VAL A 431
ALA A 443
VAL A 473
TYR A 491
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
None
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.46A 3fupB-3sxsA:
31.0		 3fupB-3sxsA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
GLY A 485
GLY A 487
VAL A 492
ALA A 512
LYS A 514
TYR A 563
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
None
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
 0.47A 3fupB-3tt0A:
28.9		 3fupB-3tt0A:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
GLY A 362
VAL A 369
ALA A 382
LYS A 384
MET A 433
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.49A 3fupB-3txoA:
8.0		 3fupB-3txoA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
GLY A 841
VAL A 848
ALA A 866
LYS A 868
VAL A 899
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.8A)
 0.52A 3fupB-3vidA:
28.1		 3fupB-3vidA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
LYS A  98
MET A 144
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
 0.45A 3fupB-3wigA:
22.8		 3fupB-3wigA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  75
GLY A  76
GLY A  78
VAL A  83
ALA A  96
MET A 144
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 (-3.3A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
 0.45A 3fupB-3wigA:
22.8		 3fupB-3wigA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
GLY A  13
VAL A  18
ALA A  31
VAL A  64
TYR A  82
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-3.6A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
 0.47A 3fupB-4aguA:
24.9		 3fupB-4aguA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 GLY A  84
VAL A  91
ALA A 104
LYS A 106
MET A 154
TYR A 156
LEU A 208
 None
None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
 0.48A 3fupB-4aw2A:
22.8		 3fupB-4aw2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
GLY A 249
VAL A 254
ALA A 267
TYR A 320
LEU A 371
 None
 0.48A 3fupB-4c0tA:
23.8		 3fupB-4c0tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
ALA A 267
LYS A 269
TYR A 320
LEU A 371
 None
 0.53A 3fupB-4c0tA:
23.8		 3fupB-4c0tA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
GLY A 666
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
 AGS  A1985 (-4.2A)
AGS  A1985 (-2.9A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
 0.62A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
VAL A 721
MET A 737
TYR A 739
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.2A)
None
AGS  A1985 (-4.8A)
 0.59A 3fupB-4crsA:
24.2		 3fupB-4crsA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
LYS A  38
VAL A  68
MET A  86
 BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 (-3.7A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.7A)
 0.60A 3fupB-4euuA:
16.8		 3fupB-4euuA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
GLY A  29
VAL A  34
ALA A  47
LYS A  49
VAL A  79
MET A  95
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-3.2A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
ATP  A 401 (-4.7A)
ATP  A 401 ( 4.3A)
 0.49A 3fupB-4fg8A:
22.4		 3fupB-4fg8A:
26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
GLY A 380
VAL A 385
ALA A 400
LYS A 402
VAL A 433
MET A 448
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-3.5A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.8A)
ANP  A 701 ( 3.7A)
 0.61A 3fupB-4fl3A:
28.7		 3fupB-4fl3A:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 LEU A 855
GLY A 856
VAL A 863
ALA A 880
LYS A 882
VAL A 911
MET A 929
TYR A 931
LEU A 932
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
None
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
 0.54A 3fupB-4gl9A:
29.1		 3fupB-4gl9A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 LEU A 855
GLY A 856
VAL A 863
LYS A 882
VAL A 911
MET A 929
LEU A 932
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 ( 4.9A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-4.4A)
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.65A 3fupB-4gl9A:
29.1		 3fupB-4gl9A:
96.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 828
GLY A 829
GLY A 831
VAL A 836
ALA A 853
LYS A 855
VAL A 884
MET A 902
TYR A 904
LEU A 905
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.7A)
19S  A1201 ( 4.3A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
19S  A1201 (-4.5A)
 0.32A 3fupB-4hviA:
32.3		 3fupB-4hviA:
61.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
GLY A 834
VAL A 836
ALA A 853
VAL A 884
MET A 902
TYR A 904
LEU A 905
 19S  A1201 (-3.9A)
19S  A1201 ( 4.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 (-3.6A)
19S  A1201 (-4.7A)
19S  A1201 (-4.4A)
 0.99A 3fupB-4hviA:
32.3		 3fupB-4hviA:
61.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
GLY A 407
VAL A 414
ALA A 427
LYS A 429
VAL A 453
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 ( 3.6A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.76A 3fupB-4idtA:
25.0		 3fupB-4idtA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		7 LEU A 258
GLY A 259
GLY A 261
VAL A 266
ALA A 279
LYS A 281
MET A 356
 ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 (-3.3A)
 0.54A 3fupB-4jrnA:
20.6		 3fupB-4jrnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
LYS A 295
VAL A 323
TYR A 340
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.7A)
 0.64A 3fupB-4k11A:
29.1		 3fupB-4k11A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
GLY A 276
VAL A 281
ALA A 293
VAL A 323
TYR A 340
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
None
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
 0.68A 3fupB-4k11A:
29.1		 3fupB-4k11A:
24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
GLY A 479
GLY A 481
VAL A 486
ALA A 506
TYR A 557
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-3.6A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 (-4.4A)
 0.48A 3fupB-4k33A:
26.6		 3fupB-4k33A:
35.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 414
ALA A 434
LYS A 436
VAL A 465
MET A 481
LEU A 484
LEU A 533
 B49  A 701 ( 4.3A)
B49  A 701 (-3.2A)
None
None
B49  A 701 (-3.4A)
B49  A 701 (-4.4A)
B49  A 701 (-4.5A)
 0.54A 3fupB-4ks8A:
26.6		 3fupB-4ks8A:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A  43
VAL A  50
ALA A  61
LYS A  63
VAL A  90
MET A 104
TYR A 106
LEU A 163
 1UL  A 501 ( 4.1A)
1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-3.6A)
1UL  A 501 (-4.1A)
1UL  A 501 (-4.3A)
 0.53A 3fupB-4l52A:
26.6		 3fupB-4l52A:
28.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
GLY B  33
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
 ADP  B 500 ( 3.8A)
ADP  B 500 (-3.3A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
 0.55A 3fupB-4o27B:
27.7		 3fupB-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
MET B  99
TYR B 101
LEU B 102
LEU B 151
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 ( 4.1A)
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.3A)
ADP  B 500 (-4.7A)
 0.53A 3fupB-4o27B:
27.7		 3fupB-4o27B:
30.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 4.2A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
 0.53A 3fupB-4oliA:
38.6		 3fupB-4oliA:
50.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
GLY A 628
GLY A 630
VAL A 635
ALA A 648
TYR A 703
LEU A 753
 None
 0.48A 3fupB-4otdA:
24.7		 3fupB-4otdA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 386
GLY A 387
GLY A 389
VAL A 394
ALA A 407
TYR A 460
LEU A 461
LEU A 511
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
PZW  A 801 (-4.3A)
PZW  A 801 (-4.8A)
 0.60A 3fupB-4q9zA:
23.6		 3fupB-4q9zA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  24
GLY A  25
GLY A  27
VAL A  32
ALA A  45
MET A  95
TYR A  97
 None
 0.55A 3fupB-4redA:
17.1		 3fupB-4redA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		9 LEU A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
MET A  95
TYR A  97
LEU A 148
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.3A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
STU  A 601 (-3.7A)
 0.59A 3fupB-4rewA:
25.9		 3fupB-4rewA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
VAL A 675
TYR A 693
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
 0.49A 3fupB-4rt7A:
22.9		 3fupB-4rt7A:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
MET A 175
TYR A 177
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
ATP  A 501 (-3.6A)
None
ATP  A 501 (-4.5A)
 0.45A 3fupB-4wb7A:
25.1		 3fupB-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		9 LEU A 104
GLY A 105
GLY A 107
VAL A 112
ALA A 125
LYS A 127
VAL A 159
MET A 175
TYR A 177
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.5A)
ATP  A 501 (-3.2A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-3.6A)
None
 0.37A 3fupB-4wb7A:
25.1		 3fupB-4wb7A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
GLY A 194
GLY A 196
VAL A 201
ALA A 214
LYS A 216
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-3.4A)
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.71A 3fupB-4wboA:
24.9		 3fupB-4wboA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
VAL A 248
MET A 264
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-3.2A)
ANW  A 601 (-4.9A)
 0.72A 3fupB-4wboA:
24.9		 3fupB-4wboA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
GLY A  35
GLY A  37
VAL A  42
ALA A  55
LYS A  57
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.5A)
ADP  A 506 (-2.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.7A)
 0.50A 3fupB-4ysjA:
26.3		 3fupB-4ysjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  23
GLY A  25
VAL A  30
ALA A  44
VAL A  76
MET A  92
TYR A  94
LEU A 145
 51W  A 401 (-3.3A)
GOL  A 404 ( 3.2A)
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
None
51W  A 401 (-3.9A)
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
 0.60A 3fupB-5ci7A:
26.2		 3fupB-5ci7A:
29.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		8 GLY A  82
GLY A  84
VAL A  89
ALA A 102
VAL A 134
MET A 150
LEU A 153
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
ANP  A 401 (-4.0A)
ANP  A 401 (-4.1A)
None
 0.73A 3fupB-5dbxA:
20.0		 3fupB-5dbxA:
26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 903
GLY A 904
VAL A 911
ALA A 928
LYS A 930
MET A 978
TYR A 980
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.46A 3fupB-5f1zA:
39.0		 3fupB-5f1zA:
50.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
GLY A 600
VAL A 607
ALA A 625
LYS A 627
VAL A 658
TYR A 676
LEU A 825
 748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.42A 3fupB-5grnA:
23.4		 3fupB-5grnA:
31.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gza PROTEIN O-MANNOSE
KINASE

(Danio rerio) 		PF07714
(Pkinase_Tyr) 		7 GLY A  86
GLY A  88
VAL A  93
ALA A 104
VAL A 133
TYR A 149
LEU A 214
 ADP  A 401 (-3.6A)
ADP  A 401 (-3.1A)
ADP  A 401 (-4.4A)
ADP  A 401 (-3.2A)
None
ADP  A 401 ( 4.8A)
ADP  A 401 (-4.4A)
 0.49A 3fupB-5gzaA:
22.2		 3fupB-5gzaA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
LEU A 187
ASP A 198
 IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.78A 3fupB-5i3oA:
25.6		 3fupB-5i3oA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  57
GLY A  60
VAL A  65
ALA A  77
LYS A  79
VAL A 109
MET A 130
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.4A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.56A 3fupB-5i3oA:
25.6		 3fupB-5i3oA:
27.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
LYS A  45
MET A  93
TYR A  95
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.3A)
 0.54A 3fupB-5isoA:
25.8		 3fupB-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
GLY A  23
VAL A  30
ALA A  43
TYR A  95
LEU A 146
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-3.4A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
 0.49A 3fupB-5isoA:
25.8		 3fupB-5isoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  23
VAL A  30
ALA A  43
LYS A  45
VAL A  74
MET A  90
LEU A 143
ASP A 154
 None
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
6G2  A 901 (-3.5A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.60A 3fupB-5j5tA:
22.3		 3fupB-5j5tA:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A 277
GLY A 279
VAL A 284
ALA A 297
TYR A 346
LEU A 347
LEU A 396
 IPW  A 601 ( 3.9A)
None
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
 0.54A 3fupB-5kbrA:
23.3		 3fupB-5kbrA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  49
ALA A  60
VAL A  94
MET A 110
TYR A 112
LEU A 113
LEU A 163
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.1A)
STU  A 901 (-4.5A)
 0.39A 3fupB-5lohA:
10.2		 3fupB-5lohA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 8 GLY A 359
GLY A 361
VAL A 366
ALA A 379
VAL A 413
MET A 429
LEU A 432
LEU A 482
 ANP  A 801 ( 4.1A)
ANP  A 801 (-3.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 ( 4.9A)
ANP  A 801 ( 4.5A)
ANP  A 801 (-4.7A)
ANP  A 801 (-4.8A)
 0.66A 3fupB-5nclA:
18.9		 3fupB-5nclA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  99
GLY A 101
VAL A 106
ALA A 119
VAL A 153
MET A 169
TYR A 171
LEU A 221
 None
 0.59A 3fupB-5u7qA:
22.4		 3fupB-5u7qA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 9 LEU A  17
GLY A  18
GLY A  20
VAL A  25
ALA A  38
LYS A  40
VAL A  72
MET A  92
TYR A  94
 G93  A 301 ( 3.8A)
G93  A 301 ( 3.2A)
None
G93  A 301 (-3.4A)
G93  A 301 ( 3.7A)
G93  A 301 (-3.0A)
G93  A 301 (-4.0A)
G93  A 301 (-2.7A)
None
 0.58A 3fupB-5u94A:
26.8		 3fupB-5u94A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 9 LEU A 686
GLY A 687
VAL A 694
ALA A 707
LYS A 709
VAL A 738
MET A 754
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 3.4A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.70A 3fupB-5vilA:
18.9		 3fupB-5vilA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
GLY A 369
VAL A 374
ALA A 388
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-3.4A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.77A 3fupB-6c0tA:
25.5		 3fupB-6c0tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
GLY A 367
VAL A 374
ALA A 388
LYS A 390
VAL A 422
MET A 438
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-3.9A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
None
EE4  A 701 ( 3.8A)
DMS  A 702 ( 3.1A)
 0.67A 3fupB-6c0tA:
25.5		 3fupB-6c0tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 9 LEU A 881
GLY A 882
GLY A 884
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
LEU A 959
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-3.3A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.6A)
 0.57A 3fupB-6c7yA:
27.9		 3fupB-6c7yA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 9 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
VAL A 938
MET A 956
LEU A 959
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.2A)
ADP  A1201 (-4.6A)
ADP  A1201 (-4.5A)
 0.55A 3fupB-6c7yA:
27.9		 3fupB-6c7yA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 8 GLY A 135
GLY A 137
VAL A 142
ALA A 155
LYS A 157
VAL A 212
LEU A 233
LEU A 282
 H1N  A 501 ( 3.8A)
None
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-4.9A)
H1N  A 501 (-4.6A)
H1N  A 501 (-4.8A)
 0.55A 3fupB-6ccfA:
24.4		 3fupB-6ccfA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 GLY A 193
GLY A 195
VAL A 200
ALA A 211
LYS A 213
TYR A 264
LEU A 318
 CJT  A 502 ( 3.9A)
None
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
CJT  A 502 (-4.7A)
 0.47A 3fupB-6f3dA:
24.8		 3fupB-6f3dA:
12.29