SIMILAR PATTERNS OF AMINO ACIDS FOR 3FSU_A_C2FA995

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		5 ASN A 286
THR A 186
TYR A 115
LEU A  51
ARG A 283
 NAD  A 600 ( 4.4A)
None
None
None
None
 1.43A 3fsuA-1ad3A:
1.0		 3fsuA-1ad3A:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		7 GLN A 183
LEU A 212
SER A 215
ASN A 216
THR A 227
TYR A 275
ARG A 279
 FAD  A 395 ( 4.4A)
None
None
None
None
None
None
 0.72A 3fsuA-1b5tA:
43.6		 3fsuA-1b5tA:
98.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b5t PROTEIN
(METHYLENETETRAHYDRO
FOLATE REDUCTASE)

(Escherichia
coli) 		PF02219
(MTHFR) 		8 THR A  59
GLN A 183
LEU A 212
SER A 215
ASN A 216
THR A 227
TYR A 275
LEU A 277
 FAD  A 395 (-3.7A)
FAD  A 395 ( 4.4A)
None
None
None
None
None
None
 0.39A 3fsuA-1b5tA:
43.6		 3fsuA-1b5tA:
98.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 587
ASN A 568
TYR A 768
LEU A 621
ARG A 565
 None
 1.30A 3fsuA-1dgjA:
undetectable		 3fsuA-1dgjA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
PF02240
(MCR_gamma) 		5 THR B2328
LEU B2397
SER C3066
ASN C3070
LEU B2313
 None
None
OCS  C3065 ( 4.1A)
None
None
 1.41A 3fsuA-1e6yB:
undetectable		 3fsuA-1e6yB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN C   6
GLN C  82
LEU C  20
THR C 112
LEU C  70
 None
 1.43A 3fsuA-1fskC:
undetectable		 3fsuA-1fskC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		5 THR A 112
LEU A  33
GLN A  16
TYR A 116
LEU A 119
 None
 1.41A 3fsuA-1ii2A:
undetectable		 3fsuA-1ii2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		5 LEU A  29
ASN A  14
LEU A  21
THR A  25
LEU A   6
 None
 1.37A 3fsuA-1j85A:
4.0		 3fsuA-1j85A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 THR A 264
LEU A 429
SER A 217
LEU A 328
THR A 459
 None
 1.25A 3fsuA-1k25A:
undetectable		 3fsuA-1k25A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLN A 429
ASN A 294
LEU A 394
THR A 404
ARG A 289
 None
 1.37A 3fsuA-1kqfA:
undetectable		 3fsuA-1kqfA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		5 LEU A  23
ASN A 154
LEU A 158
THR A 160
LEU A 124
 None
 1.38A 3fsuA-1lnsA:
undetectable		 3fsuA-1lnsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 GLN A  86
LEU A  58
GLN A 128
TYR A  85
LEU A  88
 SAH  A2002 ( 4.2A)
None
None
SAH  A2002 (-4.6A)
None
 1.42A 3fsuA-1n7jA:
undetectable		 3fsuA-1n7jA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7j PHENYLETHANOLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		5 THR A  83
LEU A  58
GLN A 128
LEU A  47
LEU A  88
 SAH  A2002 (-2.9A)
None
None
None
None
 1.36A 3fsuA-1n7jA:
undetectable		 3fsuA-1n7jA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 THR A 590
LEU A 279
LEU A 706
THR A 709
ARG A 720
 None
 1.36A 3fsuA-1q8yA:
undetectable		 3fsuA-1q8yA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU X 282
GLN X 273
LEU X 169
THR X 174
LEU X 271
 None
 1.29A 3fsuA-1r6bX:
undetectable		 3fsuA-1r6bX:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suj CONE ARRESTIN

(Ambystoma
tigrinum) 		PF00339
(Arrestin_N)
PF02752
(Arrestin_C) 		5 GLN A 234
LEU A 286
LEU A 126
THR A 236
LEU A 290
 None
 1.13A 3fsuA-1sujA:
undetectable		 3fsuA-1sujA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy3 S-ADENOSYLMETHIONINE
:TRNA
RIBOSYLTRANSFERASE-I
SOMERASE

(Bacillus
subtilis) 		PF02547
(Queuosine_synth) 		5 GLN A 133
LEU A  81
THR A  94
LEU A 115
ARG A 114
 None
 1.36A 3fsuA-1yy3A:
undetectable		 3fsuA-1yy3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 GLN E 195
GLN E 184
LEU E 357
LEU E 191
ARG E 190
 None
 1.22A 3fsuA-1z5xE:
undetectable		 3fsuA-1z5xE:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ay9 AROMATIC AMINO ACID
AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00155
(Aminotran_1_2) 		5 GLN A 226
LEU A  88
SER A 245
LEU A 271
THR A 102
 None
 1.36A 3fsuA-2ay9A:
2.4		 3fsuA-2ay9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE

(Streptococcus
pneumoniae) 		PF01288
(HPPK)
PF02152
(FolB) 		5 LEU A 228
GLN A 120
LEU A 187
THR A 190
LEU A 230
 None
 1.40A 3fsuA-2cg8A:
undetectable		 3fsuA-2cg8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 THR A 204
LEU A 151
GLN A 168
TYR A 155
LEU A 170
 None
 1.42A 3fsuA-2cvtA:
2.4		 3fsuA-2cvtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 LEU A 111
SER A  69
ASN A  73
GLN A 128
TYR A  66
 None
 1.38A 3fsuA-2d0vA:
undetectable		 3fsuA-2d0vA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dep THERMOSTABLE
CELLOXYLANASE

([Clostridium]
stercorarium) 		PF00331
(Glyco_hydro_10) 		5 ASN A 164
GLN A 160
LEU A 159
THR A 204
ARG A 167
 None
 1.17A 3fsuA-2depA:
11.6		 3fsuA-2depA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj0 PUTATIVE CITRATE
LYASE, ALFA SUBUNIT

(Streptococcus
mutans) 		PF04223
(CitF) 		5 GLN A 202
SER A 172
ASN A 177
GLN A 222
TYR A 227
 None
 1.30A 3fsuA-2hj0A:
undetectable		 3fsuA-2hj0A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLN A 285
LEU A 470
SER A 273
GLN A 267
LEU A 278
 None
 1.32A 3fsuA-2jiiA:
undetectable		 3fsuA-2jiiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kq1 BH0266 PROTEIN

(Bacillus
halodurans) 		PF07949
(YbbR) 		5 LEU A  82
ASN A   8
LEU A  11
LEU A  45
ARG A  42
 None
 1.30A 3fsuA-2kq1A:
undetectable		 3fsuA-2kq1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 LEU A 160
SER A 197
ASN A  58
LEU A 145
THR A  95
 None
 1.26A 3fsuA-2qbyA:
undetectable		 3fsuA-2qbyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnf RECOMBINATION
ENDONUCLEASE VII

(Escherichia
virus T4) 		PF02945
(Endonuclease_7)
PF09124
(Endonuc-dimeris) 		5 GLN A  13
LEU A  30
ASN A  62
TYR A  16
LEU A  56
 None
 1.32A 3fsuA-2qnfA:
undetectable		 3fsuA-2qnfA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtk PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 GLN A 130
LEU A 166
ASN A 180
LEU A 120
LEU A 202
 None
 1.42A 3fsuA-2qtkA:
undetectable		 3fsuA-2qtkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8r SENSOR PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF02702
(KdpD) 		5 GLN A 208
LEU A 126
ASN A 122
LEU A  90
LEU A   8
 None
 1.23A 3fsuA-2r8rA:
undetectable		 3fsuA-2r8rA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 LEU A 198
ASN A 201
GLN A 268
LEU A 270
THR A 184
 None
 1.34A 3fsuA-2vrcA:
undetectable		 3fsuA-2vrcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 THR A   6
LEU A 138
THR A 136
LEU A  12
ARG A 175
 None
 1.41A 3fsuA-2vrcA:
undetectable		 3fsuA-2vrcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwe ANTI-VEGF-B
MONOCLONAL ANTIBODY

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 GLN E   6
GLN E  81
LEU E  20
THR E 107
LEU E  69
 None
 1.36A 3fsuA-2vweE:
undetectable		 3fsuA-2vweE:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2d BOTULINUM NEUROTOXIN
A HEAVY CHAIN

(Clostridium
botulinum) 		PF07952
(Toxin_trans) 		5 LEU B 853
SER B 864
LEU B 796
LEU B 862
ARG B 861
 None
 1.41A 3fsuA-2w2dB:
undetectable		 3fsuA-2w2dB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		5 LEU A  28
GLN A 334
LEU A 338
LEU A  65
ARG A  21
 None
 1.39A 3fsuA-2w6dA:
2.5		 3fsuA-2w6dA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila) 		PF16849
(Glyco_transf_88) 		5 ASN A  33
GLN A  29
LEU A  28
THR A  23
LEU A  35
 None
 1.20A 3fsuA-2wzfA:
undetectable		 3fsuA-2wzfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzv NFNB PROTEIN

(Mycolicibacterium
smegmatis) 		PF00881
(Nitroreductase) 		5 THR A 189
LEU A 182
GLN A 127
LEU A 134
ARG A 135
 None
FMN  A 801 (-4.3A)
None
None
None
 1.03A 3fsuA-2wzvA:
undetectable		 3fsuA-2wzvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1o GELSOLIN NANOBODY

(Lama glama) 		PF07686
(V-set) 		5 THR A 107
LEU A  29
LEU A   4
TYR A  32
ARG A  72
 None
 1.24A 3fsuA-2x1oA:
undetectable		 3fsuA-2x1oA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		5 GLN A  42
LEU A 410
GLN A  66
LEU A  84
ARG A  87
 None
 1.16A 3fsuA-2xalA:
undetectable		 3fsuA-2xalA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		5 GLN A 356
THR A 422
LEU A 377
TYR A 359
LEU A 355
 None
 1.20A 3fsuA-2y8nA:
undetectable		 3fsuA-2y8nA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze4 PHOSPHOLIPASE D

(Streptomyces
antibioticus) 		PF13091
(PLDc_2) 		5 GLN A 387
ASN A 304
LEU A 465
TYR A 461
LEU A 346
 None
 1.21A 3fsuA-2ze4A:
undetectable		 3fsuA-2ze4A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv)
no annotation 		5 GLN C  17
THR C  15
GLN C 205
LEU D  71
THR A   7
 None
 1.18A 3fsuA-3cjiC:
undetectable		 3fsuA-3cjiC:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct9 ACETYLORNITHINE
DEACETYLASE

(Bacteroides
thetaiotaomicron) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 THR A  47
LEU A  15
TYR A 130
LEU A 117
ARG A 121
 None
 1.30A 3fsuA-3ct9A:
undetectable		 3fsuA-3ct9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 114
ASN A 117
GLN A  97
LEU A 127
LEU A 119
 None
 1.36A 3fsuA-3dduA:
undetectable		 3fsuA-3dduA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA
PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens;
Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4)
PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLN D 437
LEU A 422
THR D 440
TYR A 397
LEU A 400
 None
 1.08A 3fsuA-3dzuD:
undetectable		 3fsuA-3dzuD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 THR A  69
LEU A  39
LEU A  41
TYR A  52
LEU A  22
 None
None
None
FAD  A 301 (-4.4A)
None
 1.43A 3fsuA-3fpkA:
1.7		 3fsuA-3fpkA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7c OCCLUDIN

(Homo sapiens) 		PF07303
(Occludin_ELL) 		5 LEU A 446
SER A 495
ASN A 498
GLN A 502
LEU A 503
 None
 1.21A 3fsuA-3g7cA:
undetectable		 3fsuA-3g7cA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 149
LEU A 129
THR A 139
TYR A 146
LEU A 114
 None
 1.35A 3fsuA-3gueA:
undetectable		 3fsuA-3gueA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iby FERROUS IRON
TRANSPORT PROTEIN B

(Legionella
pneumophila) 		PF02421
(FeoB_N) 		5 GLN A 228
LEU A 234
SER A 176
GLN A 181
LEU A 186
 None
 1.43A 3fsuA-3ibyA:
undetectable		 3fsuA-3ibyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		5 GLN A  66
LEU A  38
THR A 133
LEU A  72
ARG A  75
 None
 1.33A 3fsuA-3igfA:
2.4		 3fsuA-3igfA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 189
SER P 148
ASN P 145
LEU P 140
LEU P   7
 None
 1.13A 3fsuA-3j9tP:
undetectable		 3fsuA-3j9tP:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7y PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1108C

(Streptococcus
mutans) 		PF08282
(Hydrolase_3) 		5 THR A   8
GLN A  32
LEU A  30
TYR A  21
LEU A 259
 None
 1.36A 3fsuA-3l7yA:
undetectable		 3fsuA-3l7yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		5 THR A 118
ASN A  71
GLN A  67
LEU A  46
LEU A  73
 None
 1.39A 3fsuA-3lzxA:
undetectable		 3fsuA-3lzxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mez MANNOSE-SPECIFIC
LECTIN 3 CHAIN 1
MANNOSE-SPECIFIC
LECTIN 3 CHAIN 2

(Crocus vernus;
Crocus vernus) 		PF01453
(B_lectin)
PF01453
(B_lectin) 		5 THR B 111
LEU A   5
ASN A  15
LEU A  54
LEU A  17
 None
 1.23A 3fsuA-3mezB:
undetectable		 3fsuA-3mezB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		5 LEU A  29
ASN A  14
LEU A  21
THR A  25
LEU A   6
 None
 1.38A 3fsuA-3n4kA:
undetectable		 3fsuA-3n4kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0y LIPOPROTEIN

(Colwellia
psychrerythraea) 		PF05960
(DUF885) 		5 GLN A 173
GLN A 156
LEU A  48
THR A  51
LEU A 177
 None
 1.40A 3fsuA-3o0yA:
undetectable		 3fsuA-3o0yA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR

(Pseudomonas
putida) 		PF00532
(Peripla_BP_1) 		5 LEU A 258
SER A 265
GLN A 267
LEU A 270
LEU A 239
 None
 1.40A 3fsuA-3o75A:
undetectable		 3fsuA-3o75A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 GLN A  44
LEU A  42
ASN A 135
TYR A  40
LEU A 137
 EDO  A 321 (-3.4A)
None
None
None
None
 1.42A 3fsuA-3ooxA:
undetectable		 3fsuA-3ooxA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 THR A 112
ASN A 263
LEU A 312
THR A 203
LEU A 305
 None
None
None
AMP  A 992 (-3.7A)
None
 0.98A 3fsuA-3pcoA:
undetectable		 3fsuA-3pcoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N) 		5 THR A 112
LEU A 267
LEU A 312
THR A 203
LEU A 305
 None
None
None
AMP  A 992 (-3.7A)
None
 1.28A 3fsuA-3pcoA:
undetectable		 3fsuA-3pcoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		5 LEU A 362
SER A 341
ASN A 342
LEU A  42
TYR A   6
 None
 1.27A 3fsuA-3q6tA:
undetectable		 3fsuA-3q6tA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF03816
(LytR_cpsA_psr) 		5 LEU A 138
GLN A 285
LEU A 272
THR A 295
LEU A 119
 None
 1.19A 3fsuA-3qfiA:
undetectable		 3fsuA-3qfiA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		5 LEU A 203
ASN A  90
GLN A  70
TYR A 206
LEU A  74
 None
 1.39A 3fsuA-3qxlA:
undetectable		 3fsuA-3qxlA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE

(Mycobacteroides
abscessus) 		PF13561
(adh_short_C2) 		5 GLN A 177
THR A 132
LEU A 199
GLN A 252
LEU A 178
 None
None
None
None
EDO  A 274 ( 4.1A)
 1.35A 3fsuA-3rihA:
1.8		 3fsuA-3rihA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		5 LEU A 327
ASN A  67
GLN A  63
LEU A  62
LEU A 317
 None
 1.25A 3fsuA-3ujhA:
undetectable		 3fsuA-3ujhA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 THR A 112
LEU A 169
LEU A 121
THR A 176
LEU A 106
 None
 1.43A 3fsuA-4a2qA:
undetectable		 3fsuA-4a2qA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 GLN A 245
THR A 219
LEU A 249
GLN A 569
LEU A 567
 None
 1.33A 3fsuA-4ah6A:
undetectable		 3fsuA-4ah6A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		5 THR A 185
SER A 429
GLN A 425
LEU A 163
ARG A 167
 None
 1.40A 3fsuA-4ainA:
undetectable		 3fsuA-4ainA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Neurospora
crassa) 		no annotation 5 LEU A 301
ASN A 292
LEU A 261
THR A 339
TYR A 288
 None
 0.95A 3fsuA-4bwkA:
undetectable		 3fsuA-4bwkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 THR A 169
LEU A 197
GLN A 134
THR A 149
LEU A 179
 None
 1.36A 3fsuA-4c23A:
undetectable		 3fsuA-4c23A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyj PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3-LIKE PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 LEU A 287
ASN A 278
LEU A 247
THR A 325
TYR A 274
 None
 0.91A 3fsuA-4cyjA:
undetectable		 3fsuA-4cyjA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx2 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 4

(Homo sapiens) 		PF00023
(Ank) 		5 GLN A 297
LEU A 304
LEU A 291
THR A 295
LEU A 242
 None
 1.25A 3fsuA-4dx2A:
undetectable		 3fsuA-4dx2A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 THR A 292
LEU A 137
GLN A  74
THR A 100
LEU A 148
 None
 1.24A 3fsuA-4fnqA:
2.4		 3fsuA-4fnqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		5 THR A 291
LEU A 231
GLN A 207
LEU A 208
TYR A 228
 None
 1.44A 3fsuA-4gb7A:
undetectable		 3fsuA-4gb7A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjn REGULATORY PROTEIN
SIR3

(Saccharomyces
cerevisiae) 		PF01426
(BAH) 		5 GLN K  12
LEU K  41
ASN K  81
LEU K  76
LEU K   8
 None
 1.28A 3fsuA-4jjnK:
undetectable		 3fsuA-4jjnK:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 LEU A  29
ASN A  14
LEU A  21
THR A  25
LEU A   6
 None
 1.39A 3fsuA-4kdzA:
3.6		 3fsuA-4kdzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 PUTATIVE LIPOPROTEIN

(Pseudomonas
protegens) 		no annotation 5 GLN B  45
LEU B  47
THR B 111
TYR B  56
LEU B  58
 None
 1.25A 3fsuA-4kt3B:
undetectable		 3fsuA-4kt3B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		5 THR A 134
LEU A 125
GLN A  96
LEU A 121
ARG A  89
 None
 1.41A 3fsuA-4kvoA:
undetectable		 3fsuA-4kvoA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		5 THR A 295
SER A 273
ASN A 272
GLN A 268
LEU A 287
 None
 1.13A 3fsuA-4nkyA:
undetectable		 3fsuA-4nkyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 LEU A2099
SER A2107
GLN A2096
THR A1806
TYR A2086
 None
 1.38A 3fsuA-4o9xA:
undetectable		 3fsuA-4o9xA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 GLN A 590
LEU A 367
TYR A 370
LEU A 371
ARG A 493
 None
 1.30A 3fsuA-4qlbA:
undetectable		 3fsuA-4qlbA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 THR A 310
LEU A 262
GLN A 255
THR A 225
LEU A 295
 None
 1.44A 3fsuA-4tnmA:
undetectable		 3fsuA-4tnmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4unr THYMIDYLATE KINASE

(Mycobacterium
tuberculosis) 		PF02223
(Thymidylate_kin) 		5 GLN A 136
LEU A  93
GLN A  82
LEU A 130
LEU A   2
 None
 1.21A 3fsuA-4unrA:
undetectable		 3fsuA-4unrA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLN A 151
LEU A 197
LEU A 109
THR A 113
ARG A 203
 None
 1.41A 3fsuA-4uphA:
undetectable		 3fsuA-4uphA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		5 LEU A 282
ASN A 296
LEU A 301
LEU A  34
ARG A 293
 None
None
None
None
SO4  A 403 (-4.4A)
 1.39A 3fsuA-4y1pA:
undetectable		 3fsuA-4y1pA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3l NUP54
NUCLEOPORIN NUP58
NUCLEOPORIN NUP62

(Xenopus laevis;
Xenopus laevis;
Xenopus laevis) 		PF13874
(Nup54)
PF15967
(Nucleoporin_FG2)
PF05064
(Nsp1_C) 		5 GLN A 402
GLN C 425
LEU C 418
LEU B 345
THR B 349
 None
 1.20A 3fsuA-5c3lA:
undetectable		 3fsuA-5c3lA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		5 ASN A 495
GLN A 491
LEU A 490
THR A 485
LEU A 497
 None
 1.12A 3fsuA-5ecoA:
undetectable		 3fsuA-5ecoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jym ANTIBODY SCFV TSP11

(Mus musculus) 		PF07686
(V-set) 		5 GLN B   6
GLN B  82
LEU B  20
THR B 116
LEU B  70
 None
 1.40A 3fsuA-5jymB:
undetectable		 3fsuA-5jymB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k2y PROBABLE PERIPLASMIC
SUGAR-BINDING
LIPOPROTEIN USPC

(Mycobacterium
tuberculosis) 		PF01547
(SBP_bac_1) 		5 LEU A 286
GLN A 166
LEU A 170
TYR A 211
LEU A 187
 None
 1.42A 3fsuA-5k2yA:
undetectable		 3fsuA-5k2yA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 THR A 468
ASN A 859
LEU A  55
THR A  52
LEU A  75
 None
 1.26A 3fsuA-5nd1A:
undetectable		 3fsuA-5nd1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		5 GLN E 141
SER E  32
LEU E  45
TYR E 121
LEU E 123
 None
 1.37A 3fsuA-5u8sE:
undetectable		 3fsuA-5u8sE:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		7 THR A  57
GLN A 181
LEU A 210
ASN A 214
THR A 225
TYR A 273
ARG A 277
 FAD  A 300 (-4.4A)
ACY  A 302 ( 3.9A)
None
None
None
ACY  A 302 ( 4.0A)
None
 0.69A 3fsuA-5umeA:
42.9		 3fsuA-5umeA:
72.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ume 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE

(Haemophilus
influenzae) 		PF02219
(MTHFR) 		7 THR A  57
GLN A 181
LEU A 210
ASN A 214
THR A 225
TYR A 273
LEU A 275
 FAD  A 300 (-4.4A)
ACY  A 302 ( 3.9A)
None
None
None
ACY  A 302 ( 4.0A)
None
 0.46A 3fsuA-5umeA:
42.9		 3fsuA-5umeA:
72.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 5 GLN A1114
LEU A1120
GLN A 987
TYR A1117
LEU A1116
 None
 1.19A 3fsuA-5wnoA:
undetectable		 3fsuA-5wnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		5 GLN A  93
LEU A 202
LEU A 217
LEU A 276
ARG A 100
 None
 1.04A 3fsuA-5xvnA:
undetectable		 3fsuA-5xvnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 5 THR A  20
SER A 239
LEU A 314
THR A   3
ARG A 248
 ACP  A 500 ( 3.9A)
None
None
None
ACP  A 500 (-3.1A)
 1.43A 3fsuA-6ci7A:
undetectable		 3fsuA-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 5 LEU A 443
LEU A 486
THR A 407
TYR A 447
LEU A 304
 None
None
EDO  A 615 (-4.1A)
None
None
 1.18A 3fsuA-6dk2A:
undetectable		 3fsuA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxo RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
BLDN

(Streptomyces
venezuelae;
Streptomyces
venezuelae) 		no annotation
no annotation 		5 GLN A 130
THR A 134
GLN D  57
LEU D  58
THR A  44
 None
 1.37A 3fsuA-6dxoA:
undetectable		 3fsuA-6dxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 5 GLN A 291
LEU A 292
SER A 263
LEU A 136
ARG A 265
 FAD  A 501 (-4.7A)
None
None
None
None
 1.43A 3fsuA-6fn0A:
undetectable		 3fsuA-6fn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 5 THR A 604
LEU A 576
LEU A 502
LEU A 596
ARG A 593
 None
 1.12A 3fsuA-6gh2A:
undetectable		 3fsuA-6gh2A:
undetectable