SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRQ_B_ERYB195_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		5 LEU A  76
GLY A 254
ILE A  28
SER A  27
ILE A  18
 None
 0.97A 3frqB-1apaA:
0.0		 3frqB-1apaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		6 GLY A   4
VAL A  53
LEU A  74
SER A 159
VAL A  28
ILE A 236
 None
 1.36A 3frqB-1ce7A:
undetectable		 3frqB-1ce7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A 215
GLY A 349
LEU A 358
ILE A 241
SER A 240
 None
IUM  A1102 (-3.8A)
None
None
None
 0.96A 3frqB-1ct9A:
0.0		 3frqB-1ct9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 GLY A 194
VAL A 163
LEU A 152
VAL A 115
ILE A 143
 None
 0.95A 3frqB-1e1cA:
0.0		 3frqB-1e1cA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 250
TYR A  35
LEU A 134
SER A 259
ILE A 159
 None
 1.05A 3frqB-1ez4A:
0.0		 3frqB-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		5 THR A 306
ILE A 300
SER A 198
VAL A 290
ILE A 247
 None
 1.06A 3frqB-1ezwA:
0.0		 3frqB-1ezwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 108
GLY A  75
VAL A  79
TYR A  82
ILE A  38
 None
 1.06A 3frqB-1fpsA:
2.7		 3frqB-1fpsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 193
GLY A 184
ILE A 258
SER A 157
VAL A 343
 None
None
None
FAD  A 451 ( 3.9A)
NAD  A 452 ( 4.7A)
 1.07A 3frqB-1geuA:
undetectable		 3frqB-1geuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 534
VAL A 536
ILE A 328
VAL A 550
ILE A 301
 None
 1.06A 3frqB-1gpeA:
0.0		 3frqB-1gpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus;
Equus caballus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 LEU A 260
GLY A  48
LEU A 299
ILE B 371
ILE A  57
 None
 0.82A 3frqB-1hleA:
undetectable		 3frqB-1hleA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 GLY A 114
VAL A 116
SER A 156
VAL A  11
ILE A  61
 None
NAP  A1350 (-3.9A)
None
NAP  A1350 (-3.8A)
None
 1.06A 3frqB-1i36A:
2.2		 3frqB-1i36A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		5 THR A 142
LEU A 145
ILE A 168
VAL A 239
ILE A 248
 None
 1.03A 3frqB-1jjfA:
undetectable		 3frqB-1jjfA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 133
TYR A 125
SER A  48
ILE A 389
SER A  42
 None
None
NAD  A1403 (-2.7A)
None
None
 1.04A 3frqB-1kolA:
undetectable		 3frqB-1kolA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		5 LEU A  38
VAL A 102
TYR A 176
ILE A  51
ILE A  91
 None
 0.99A 3frqB-1lvwA:
0.1		 3frqB-1lvwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 394
LEU A 330
SER A 333
VAL A 356
ILE A 373
 None
 1.04A 3frqB-1muuA:
undetectable		 3frqB-1muuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A  89
LEU A  60
ILE A 128
SER A 129
ILE A 348
 None
 1.06A 3frqB-1pojA:
undetectable		 3frqB-1pojA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 732
GLY A 718
VAL A 716
LEU A 658
VAL A 674
 None
 1.04A 3frqB-1qgrA:
undetectable		 3frqB-1qgrA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 THR A 143
GLY A 100
LEU A 129
VAL A 113
ILE A 157
 None
 0.96A 3frqB-1qgrA:
undetectable		 3frqB-1qgrA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 THR A  65
LEU A  64
VAL A  28
TYR A  26
VAL A   6
 None
 1.05A 3frqB-1qrrA:
undetectable		 3frqB-1qrrA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 235
LEU A 206
SER A 321
VAL A 194
ILE A 363
 None
 1.06A 3frqB-1ry2A:
undetectable		 3frqB-1ry2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		5 THR A  18
GLY A  14
LEU A  56
VAL A   6
ILE A  71
 None
 0.94A 3frqB-1t06A:
undetectable		 3frqB-1t06A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 THR A  41
LEU A  44
GLY A  68
LEU A 208
ILE A  62
 None
 0.99A 3frqB-1upxA:
undetectable		 3frqB-1upxA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		6 LEU A 271
GLY A 290
LEU A 319
ILE A 240
VAL A 315
ILE A 216
 None
 1.03A 3frqB-1uz5A:
undetectable		 3frqB-1uz5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 LEU A   4
VAL A 149
LEU A1139
VAL A1159
ILE A1171
 None
 1.06A 3frqB-1w1wA:
undetectable		 3frqB-1w1wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU I 161
GLY I 134
SER I 225
ILE I 159
VAL I 258
 None
NDP  I 600 (-4.0A)
NDP  I 600 (-4.9A)
None
None
 1.03A 3frqB-1yveI:
undetectable		 3frqB-1yveI:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		5 VAL A  86
LEU A 148
SER A 241
VAL A  66
ILE A 232
 None
 1.03A 3frqB-1yw4A:
undetectable		 3frqB-1yw4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 THR A 338
GLY A 172
LEU A 124
VAL A 140
ILE A  18
 None
 1.04A 3frqB-1zapA:
undetectable		 3frqB-1zapA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr4 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		5 LEU A  69
GLY A   5
VAL A  28
ILE A  90
SER A  89
 None
 0.97A 3frqB-1zr4A:
undetectable		 3frqB-1zr4A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 LEU A 119
VAL A 225
LEU A 248
ILE A 121
ILE A 211
 None
 0.99A 3frqB-2a5hA:
undetectable		 3frqB-2a5hA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
pyogenes) 		PF00156
(Pribosyltran) 		5 THR A 172
LEU A 173
LEU A 197
ILE A   7
ILE A 189
 None
 1.04A 3frqB-2aeeA:
undetectable		 3frqB-2aeeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		6 LEU A  96
GLY A  74
LEU A 225
SER A 247
ILE A 119
ILE A 206
 None
 1.29A 3frqB-2gzaA:
undetectable		 3frqB-2gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY D  60
VAL D  56
LEU D  35
VAL D  68
ILE D  22
 None
 1.03A 3frqB-2j7pD:
undetectable		 3frqB-2j7pD:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 LEU A 244
TYR A 332
MET A 339
ILE A 313
ILE A 278
 None
 0.99A 3frqB-2qmiA:
undetectable		 3frqB-2qmiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 150
GLY A 118
ILE A 395
VAL A  52
ILE A  23
 None
 1.02A 3frqB-2qt3A:
undetectable		 3frqB-2qt3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv0 PROTEIN MRKE

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		5 LEU A 121
ILE A  77
SER A  74
VAL A  95
ILE A 113
 None
 0.82A 3frqB-2qv0A:
undetectable		 3frqB-2qv0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 THR A  44
LEU A  21
LEU A 176
ILE A 229
ILE A 430
 None
None
None
None
FAD  A 609 (-3.5A)
 0.95A 3frqB-2rghA:
undetectable		 3frqB-2rghA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		5 GLY A  34
LEU A 183
ILE A   7
VAL A 179
ILE A 190
 None
 1.00A 3frqB-2sfaA:
undetectable		 3frqB-2sfaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLY A1005
LEU A 980
SER A1024
VAL A1013
ILE A 930
 None
None
FMN  A2474 ( 4.2A)
None
None
 0.97A 3frqB-2vdcA:
undetectable		 3frqB-2vdcA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 LEU A 209
GLY A  88
SER A 122
ILE A 219
SER A 218
 None
 1.06A 3frqB-2w5fA:
undetectable		 3frqB-2w5fA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 135
GLY A 116
ILE A 109
VAL A  35
ILE A  24
 None
 1.00A 3frqB-2wtbA:
undetectable		 3frqB-2wtbA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 GLY A 215
VAL A 184
LEU A 173
VAL A 136
ILE A 164
 None
 1.06A 3frqB-2xijA:
undetectable		 3frqB-2xijA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 THR A 366
LEU A 369
GLY A 348
ILE A 293
VAL A 239
 ZN  A1673 ( 4.8A)
None
None
None
None
 0.85A 3frqB-2xpzA:
undetectable		 3frqB-2xpzA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		5 LEU A 136
GLY A 130
ILE A  63
VAL A 156
ILE A 188
 None
 0.95A 3frqB-2ynmA:
undetectable		 3frqB-2ynmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		5 VAL A  73
MET A  86
ILE A  47
VAL A   3
ILE A 112
 None
 1.06A 3frqB-2yzqA:
undetectable		 3frqB-2yzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A  26
LEU A 270
ILE A   8
VAL A 268
ILE A 256
 None
 0.94A 3frqB-3a14A:
undetectable		 3frqB-3a14A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLY A 200
VAL A 203
LEU A  32
VAL A 275
ILE A 123
 None
 1.03A 3frqB-3a24A:
undetectable		 3frqB-3a24A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 316
LEU A  68
SER A  37
VAL A 314
ILE A 301
 None
 1.01A 3frqB-3abbA:
0.8		 3frqB-3abbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 GLY A 180
VAL A 178
ILE A 309
SER A 306
ILE A 103
 None
HIU  A 502 (-4.6A)
None
None
None
 1.01A 3frqB-3bptA:
undetectable		 3frqB-3bptA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 LEU A 183
VAL A 174
LEU A 128
SER A 157
ILE A 115
 None
 1.01A 3frqB-3c0kA:
undetectable		 3frqB-3c0kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0r UBIQUITIN
THIOESTERASE OTU1

(Saccharomyces
cerevisiae) 		PF02338
(OTU) 		5 LEU A 138
GLY A 128
ILE A 184
SER A 185
ILE A 202
 None
 1.04A 3frqB-3c0rA:
undetectable		 3frqB-3c0rA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04099
(Sybindin)
PF04099
(Sybindin) 		5 GLY C  73
LEU C  44
ILE A 131
VAL C  77
ILE C  48
 None
 1.05A 3frqB-3cueC:
undetectable		 3frqB-3cueC:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		5 LEU A 235
LEU A 151
ILE A 197
VAL A  81
ILE A  78
 None
 0.83A 3frqB-3cyvA:
undetectable		 3frqB-3cyvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		6 LEU A 250
GLY A  87
VAL A 113
LEU A 125
ILE A  98
VAL A 149
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.1A)
None
None
None
None
 1.49A 3frqB-3f4bA:
undetectable		 3frqB-3f4bA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 289
LEU A 149
ILE A 262
VAL A 183
ILE A 220
 None
 0.97A 3frqB-3fe2A:
undetectable		 3frqB-3fe2A:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		12 THR A  17
LEU A  20
GLY A  62
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
ILE A 105
SER A 106
VAL A 126
ILE A 150
 ERY  A 195 (-4.4A)
None
ERY  A 195 ( 4.1A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 ( 4.3A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
 0.50A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 426
LEU A 286
ILE A 399
VAL A 321
ILE A 357
 None
 1.03A 3frqB-3iuyA:
undetectable		 3frqB-3iuyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro NUCLEOPORIN NUP84

(Saccharomyces
cerevisiae) 		PF04121
(Nup84_Nup100) 		5 VAL C  78
LEU C 355
SER C 349
ILE C 388
ILE C 359
 None
 1.07A 3frqB-3jroC:
undetectable		 3frqB-3jroC:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 212
GLY B 251
LEU B 288
SER B 224
ILE B 295
 None
 1.05A 3frqB-3ogkB:
undetectable		 3frqB-3ogkB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		5 LEU D  55
GLY D 132
SER D 150
ILE D  41
SER D  40
 None
 1.02A 3frqB-3ossD:
undetectable		 3frqB-3ossD:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 212
GLY A 245
LEU A 299
ILE A 240
ILE A 266
 None
 0.90A 3frqB-3ozyA:
undetectable		 3frqB-3ozyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A  14
GLY A 543
VAL A 797
SER A  38
ILE A 669
 None
None
None
PPV  A1002 (-2.7A)
None
 0.98A 3frqB-3pihA:
undetectable		 3frqB-3pihA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 268
LEU A  35
MET A 260
VAL A  39
ILE A 209
 None
 1.06A 3frqB-3pkjA:
0.1		 3frqB-3pkjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 THR B  95
LEU B  96
VAL B  21
ILE B 118
SER B 117
 None
 0.85A 3frqB-3pntB:
undetectable		 3frqB-3pntB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 235
TYR A  20
LEU A 119
SER A 152
ILE A 144
 None
 1.04A 3frqB-3pqdA:
undetectable		 3frqB-3pqdA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 203
LEU A 207
GLY A 165
ILE A 189
ILE A  54
 None
 0.99A 3frqB-3q4dA:
undetectable		 3frqB-3q4dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb2 IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 THR A  95
LEU A  96
VAL A  21
ILE A 118
SER A 117
 None
 0.95A 3frqB-3qb2A:
undetectable		 3frqB-3qb2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk FUSION OF UREASE
BETA AND GAMMA
SUBUNITS
UREASE SUBUNIT BETA
2

(Helicobacter
mustelae;
Helicobacter
mustelae) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY A 191
LEU C  42
SER A 170
ILE A 195
ILE C  50
 None
 1.06A 3frqB-3qgkA:
undetectable		 3frqB-3qgkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 5 THR A  16
LEU A  19
VAL A 229
MET A 153
VAL A 257
 UDP  A 400 (-3.0A)
None
None
None
None
 0.95A 3frqB-3qkwA:
undetectable		 3frqB-3qkwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 126
GLY A 115
LEU A 362
ILE A 281
ILE A  29
 None
 0.85A 3frqB-3sjnA:
undetectable		 3frqB-3sjnA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 491
VAL A 487
LEU A 421
VAL A 509
ILE A 296
 None
 0.96A 3frqB-3tv2A:
2.0		 3frqB-3tv2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 327
GLY A 680
LEU A 663
SER A 316
ILE A  10
 None
 0.98A 3frqB-3wiqA:
undetectable		 3frqB-3wiqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 149
LEU A 150
VAL A 244
ILE A 236
VAL A   8
 None
 1.03A 3frqB-3wsvA:
undetectable		 3frqB-3wsvA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		5 VAL A 188
LEU A 415
ILE A  79
VAL A 168
ILE A 210
 None
None
None
FAD  A1492 (-3.8A)
FAD  A1492 (-3.5A)
 1.05A 3frqB-4b67A:
undetectable		 3frqB-4b67A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		6 GLY A1118
LEU A1127
SER A1126
ILE A1061
SER A1057
ILE A1179
 None
 1.42A 3frqB-4bocA:
undetectable		 3frqB-4bocA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 497
LEU A 569
ILE A 501
VAL A 565
ILE A 591
 None
 1.04A 3frqB-4bsnA:
2.3		 3frqB-4bsnA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 GLY A  61
LEU A 162
ILE A  53
VAL A 117
ILE A 156
 None
 0.92A 3frqB-4c2lA:
undetectable		 3frqB-4c2lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 VAL B 261
LEU B 140
ILE B 160
VAL B 237
ILE B 136
 None
 0.86A 3frqB-4ccyB:
undetectable		 3frqB-4ccyB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
VAL A  30
LEU A  18
ILE A  61
ILE A  13
 STU  A1550 (-3.8A)
None
None
None
None
 0.98A 3frqB-4cfhA:
undetectable		 3frqB-4cfhA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A  85
LEU A 367
ILE A  76
VAL A  34
ILE A 121
 None
 1.05A 3frqB-4dioA:
undetectable		 3frqB-4dioA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		5 THR A 242
VAL A 319
TYR A 322
SER A 182
VAL A 255
 None
 0.93A 3frqB-4ej0A:
undetectable		 3frqB-4ej0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 LEU A 263
GLY A 317
LEU A 355
ILE A 278
ILE A 231
 None
 1.07A 3frqB-4ifqA:
undetectable		 3frqB-4ifqA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2f GLUTATHIONE
S-TRANSFERASE

(Ricinus
communis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 202
GLY A 160
SER A  67
ILE A 198
VAL A  98
 None
 0.95A 3frqB-4j2fA:
undetectable		 3frqB-4j2fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 134
TYR A 126
SER A  49
ILE A 390
SER A  43
 None
None
NAD  A 403 ( 3.0A)
None
None
 1.06A 3frqB-4jlwA:
undetectable		 3frqB-4jlwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		5 GLY A 325
TYR A 353
LEU A 336
SER A 201
ILE A 300
 None
 1.03A 3frqB-4k25A:
undetectable		 3frqB-4k25A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		5 GLY A 170
VAL A 202
SER A 250
ILE A 167
ILE A  41
 None
 1.04A 3frqB-4l3wA:
undetectable		 3frqB-4l3wA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 THR A  41
GLY A 279
VAL A 281
LEU A 345
ILE A  50
 None
 1.01A 3frqB-4lz6A:
undetectable		 3frqB-4lz6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 GLY A 391
VAL A  80
LEU A 126
ILE A 326
VAL A  77
 None
 0.84A 3frqB-4obsA:
undetectable		 3frqB-4obsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00198
(2-oxoacid_dh) 		5 GLY A  97
LEU A 189
ILE A 122
SER A 123
VAL A 175
 None
 1.04A 3frqB-4ofsA:
undetectable		 3frqB-4ofsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		5 GLY A 421
LEU A 284
ILE A 305
VAL A 383
ILE A 278
 ANP  A 501 (-4.8A)
None
ALY  A 508 ( 4.6A)
None
None
 1.04A 3frqB-4q6gA:
undetectable		 3frqB-4q6gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 LEU A 222
GLY A 237
LEU A 100
VAL A 359
ILE A 103
 None
 1.05A 3frqB-4w87A:
undetectable		 3frqB-4w87A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 THR A 174
LEU A 173
LEU A 160
ILE A 118
ILE A  49
 AZM  A 302 (-3.3A)
AZM  A 302 (-3.7A)
None
PE8  A 303 (-4.9A)
None
 1.02A 3frqB-4x5sA:
undetectable		 3frqB-4x5sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 LEU A 522
GLY A 576
VAL A 572
ILE A 516
ILE A   4
 None
 1.03A 3frqB-4zajA:
undetectable		 3frqB-4zajA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 GLY A  58
VAL A  26
LEU A 108
ILE A  61
VAL A  77
 None
 1.00A 3frqB-4zhjA:
undetectable		 3frqB-4zhjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 VAL A 179
LEU A 419
ILE A 184
VAL A 423
ILE A 375
 None
 1.07A 3frqB-4zxlA:
undetectable		 3frqB-4zxlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 THR A 322
LEU A 449
ILE A 469
VAL A 422
ILE A 480
 None
 1.03A 3frqB-5affA:
2.0		 3frqB-5affA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 THR A 613
LEU A 612
LEU A1349
ILE A 477
ILE A1331
 None
 0.98A 3frqB-5amqA:
undetectable		 3frqB-5amqA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 5 LEU A 287
GLY A 480
ILE A 393
SER A 394
ILE A 534
 None
None
NAD  A 702 (-4.3A)
None
None
 0.99A 3frqB-5bjxA:
undetectable		 3frqB-5bjxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdd STRUCTURAL
POLYPROTEIN, VP2

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		5 GLY C 225
VAL C 145
LEU C 139
MET C 149
ILE C 237
 None
 1.03A 3frqB-5cddC:
undetectable		 3frqB-5cddC:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 GLY A 430
LEU A 148
SER A 151
SER A 410
VAL A 385
 None
 1.00A 3frqB-5d2eA:
undetectable		 3frqB-5d2eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A  30
GLY A  33
LEU A  60
VAL A  55
ILE A  89
 None
 0.88A 3frqB-5dt9A:
0.1		 3frqB-5dt9A:
20.72