SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRQ_B_ERYB195

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		5 LEU A  76
GLY A 254
ILE A  28
SER A  27
ILE A  18
 None
 0.97A 3frqB-1apaA:
0.0		 3frqB-1apaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		6 GLY A   4
VAL A  53
LEU A  74
SER A 159
VAL A  28
ILE A 236
 None
 1.36A 3frqB-1ce7A:
undetectable		 3frqB-1ce7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ct9 ASPARAGINE
SYNTHETASE B

(Escherichia
coli) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A 215
GLY A 349
LEU A 358
ILE A 241
SER A 240
 None
IUM  A1102 (-3.8A)
None
None
None
 0.96A 3frqB-1ct9A:
0.0		 3frqB-1ct9A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 GLY A 194
VAL A 163
LEU A 152
VAL A 115
ILE A 143
 None
 0.95A 3frqB-1e1cA:
0.0		 3frqB-1e1cA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 250
TYR A  35
LEU A 134
SER A 259
ILE A 159
 None
 1.05A 3frqB-1ez4A:
0.0		 3frqB-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanopyrus
kandleri) 		PF00296
(Bac_luciferase) 		5 THR A 306
ILE A 300
SER A 198
VAL A 290
ILE A 247
 None
 1.06A 3frqB-1ezwA:
0.0		 3frqB-1ezwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 108
GLY A  75
VAL A  79
TYR A  82
ILE A  38
 None
 1.06A 3frqB-1fpsA:
2.7		 3frqB-1fpsA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geu GLUTATHIONE
REDUCTASE

(Escherichia
coli) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 THR A 193
GLY A 184
ILE A 258
SER A 157
VAL A 343
 None
None
None
FAD  A 451 ( 3.9A)
NAD  A 452 ( 4.7A)
 1.07A 3frqB-1geuA:
undetectable		 3frqB-1geuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLY A 534
VAL A 536
ILE A 328
VAL A 550
ILE A 301
 None
 1.06A 3frqB-1gpeA:
0.0		 3frqB-1gpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus;
Equus caballus) 		PF00079
(Serpin)
PF00079
(Serpin) 		5 LEU A 260
GLY A  48
LEU A 299
ILE B 371
ILE A  57
 None
 0.82A 3frqB-1hleA:
undetectable		 3frqB-1hleA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 GLY A 114
VAL A 116
SER A 156
VAL A  11
ILE A  61
 None
NAP  A1350 (-3.9A)
None
NAP  A1350 (-3.8A)
None
 1.06A 3frqB-1i36A:
2.2		 3frqB-1i36A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		5 THR A 142
LEU A 145
ILE A 168
VAL A 239
ILE A 248
 None
 1.03A 3frqB-1jjfA:
undetectable		 3frqB-1jjfA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 133
TYR A 125
SER A  48
ILE A 389
SER A  42
 None
None
NAD  A1403 (-2.7A)
None
None
 1.04A 3frqB-1kolA:
undetectable		 3frqB-1kolA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvw GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Methanothermobacter
thermautotrophicus) 		PF00483
(NTP_transferase) 		5 LEU A  38
VAL A 102
TYR A 176
ILE A  51
ILE A  91
 None
 0.99A 3frqB-1lvwA:
0.1		 3frqB-1lvwA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1muu GDP-MANNOSE
6-DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 LEU A 394
LEU A 330
SER A 333
VAL A 356
ILE A 373
 None
 1.04A 3frqB-1muuA:
undetectable		 3frqB-1muuA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A  89
LEU A  60
ILE A 128
SER A 129
ILE A 348
 None
 1.06A 3frqB-1pojA:
undetectable		 3frqB-1pojA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 732
GLY A 718
VAL A 716
LEU A 658
VAL A 674
 None
 1.04A 3frqB-1qgrA:
undetectable		 3frqB-1qgrA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 THR A 143
GLY A 100
LEU A 129
VAL A 113
ILE A 157
 None
 0.96A 3frqB-1qgrA:
undetectable		 3frqB-1qgrA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 THR A  65
LEU A  64
VAL A  28
TYR A  26
VAL A   6
 None
 1.05A 3frqB-1qrrA:
undetectable		 3frqB-1qrrA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 GLY A 235
LEU A 206
SER A 321
VAL A 194
ILE A 363
 None
 1.06A 3frqB-1ry2A:
undetectable		 3frqB-1ry2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t06 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		5 THR A  18
GLY A  14
LEU A  56
VAL A   6
ILE A  71
 None
 0.94A 3frqB-1t06A:
undetectable		 3frqB-1t06A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1upx HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF03063
(Prismane) 		5 THR A  41
LEU A  44
GLY A  68
LEU A 208
ILE A  62
 None
 0.99A 3frqB-1upxA:
undetectable		 3frqB-1upxA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		6 LEU A 271
GLY A 290
LEU A 319
ILE A 240
VAL A 315
ILE A 216
 None
 1.03A 3frqB-1uz5A:
undetectable		 3frqB-1uz5A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		5 LEU A   4
VAL A 149
LEU A1139
VAL A1159
ILE A1171
 None
 1.06A 3frqB-1w1wA:
undetectable		 3frqB-1w1wA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU I 161
GLY I 134
SER I 225
ILE I 159
VAL I 258
 None
NDP  I 600 (-4.0A)
NDP  I 600 (-4.9A)
None
None
 1.03A 3frqB-1yveI:
undetectable		 3frqB-1yveI:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		5 VAL A  86
LEU A 148
SER A 241
VAL A  66
ILE A 232
 None
 1.03A 3frqB-1yw4A:
undetectable		 3frqB-1yw4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zap SECRETED ASPARTIC
PROTEINASE

(Candida
albicans) 		PF00026
(Asp) 		5 THR A 338
GLY A 172
LEU A 124
VAL A 140
ILE A  18
 None
 1.04A 3frqB-1zapA:
undetectable		 3frqB-1zapA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr4 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		5 LEU A  69
GLY A   5
VAL A  28
ILE A  90
SER A  89
 None
 0.97A 3frqB-1zr4A:
undetectable		 3frqB-1zr4A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		5 LEU A 119
VAL A 225
LEU A 248
ILE A 121
ILE A 211
 None
 0.99A 3frqB-2a5hA:
undetectable		 3frqB-2a5hA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aee OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
pyogenes) 		PF00156
(Pribosyltran) 		5 THR A 172
LEU A 173
LEU A 197
ILE A   7
ILE A 189
 None
 1.04A 3frqB-2aeeA:
undetectable		 3frqB-2aeeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		6 LEU A  96
GLY A  74
LEU A 225
SER A 247
ILE A 119
ILE A 206
 None
 1.29A 3frqB-2gzaA:
undetectable		 3frqB-2gzaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 GLY D  60
VAL D  56
LEU D  35
VAL D  68
ILE D  22
 None
 1.03A 3frqB-2j7pD:
undetectable		 3frqB-2j7pD:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		5 LEU A 244
TYR A 332
MET A 339
ILE A 313
ILE A 278
 None
 0.99A 3frqB-2qmiA:
undetectable		 3frqB-2qmiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 150
GLY A 118
ILE A 395
VAL A  52
ILE A  23
 None
 1.02A 3frqB-2qt3A:
undetectable		 3frqB-2qt3A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv0 PROTEIN MRKE

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		5 LEU A 121
ILE A  77
SER A  74
VAL A  95
ILE A 113
 None
 0.82A 3frqB-2qv0A:
undetectable		 3frqB-2qv0A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 THR A  44
LEU A  21
LEU A 176
ILE A 229
ILE A 430
 None
None
None
None
FAD  A 609 (-3.5A)
 0.95A 3frqB-2rghA:
undetectable		 3frqB-2rghA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2sfa SERINE PROTEINASE

(Streptomyces
fradiae) 		PF00089
(Trypsin) 		5 GLY A  34
LEU A 183
ILE A   7
VAL A 179
ILE A 190
 None
 1.00A 3frqB-2sfaA:
undetectable		 3frqB-2sfaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 GLY A1005
LEU A 980
SER A1024
VAL A1013
ILE A 930
 None
None
FMN  A2474 ( 4.2A)
None
None
 0.97A 3frqB-2vdcA:
undetectable		 3frqB-2vdcA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 LEU A 209
GLY A  88
SER A 122
ILE A 219
SER A 218
 None
 1.06A 3frqB-2w5fA:
undetectable		 3frqB-2w5fA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 135
GLY A 116
ILE A 109
VAL A  35
ILE A  24
 None
 1.00A 3frqB-2wtbA:
undetectable		 3frqB-2wtbA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 GLY A 215
VAL A 184
LEU A 173
VAL A 136
ILE A 164
 None
 1.06A 3frqB-2xijA:
undetectable		 3frqB-2xijA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 THR A 366
LEU A 369
GLY A 348
ILE A 293
VAL A 239
 ZN  A1673 ( 4.8A)
None
None
None
None
 0.85A 3frqB-2xpzA:
undetectable		 3frqB-2xpzA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE
IRON-SULFUR
ATP-BINDING PROTEIN

(Prochlorococcus
marinus) 		PF00142
(Fer4_NifH) 		5 LEU A 136
GLY A 130
ILE A  63
VAL A 156
ILE A 188
 None
 0.95A 3frqB-2ynmA:
undetectable		 3frqB-2ynmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzq PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780

(Pyrococcus
horikoshii) 		PF00571
(CBS) 		5 VAL A  73
MET A  86
ILE A  47
VAL A   3
ILE A 112
 None
 1.06A 3frqB-2yzqA:
undetectable		 3frqB-2yzqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a14 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Thermotoga
maritima) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		5 VAL A  26
LEU A 270
ILE A   8
VAL A 268
ILE A 256
 None
 0.94A 3frqB-3a14A:
undetectable		 3frqB-3a14A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 GLY A 200
VAL A 203
LEU A  32
VAL A 275
ILE A 123
 None
 1.03A 3frqB-3a24A:
undetectable		 3frqB-3a24A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 316
LEU A  68
SER A  37
VAL A 314
ILE A 301
 None
 1.01A 3frqB-3abbA:
0.8		 3frqB-3abbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 GLY A 180
VAL A 178
ILE A 309
SER A 306
ILE A 103
 None
HIU  A 502 (-4.6A)
None
None
None
 1.01A 3frqB-3bptA:
undetectable		 3frqB-3bptA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 LEU A 183
VAL A 174
LEU A 128
SER A 157
ILE A 115
 None
 1.01A 3frqB-3c0kA:
undetectable		 3frqB-3c0kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0r UBIQUITIN
THIOESTERASE OTU1

(Saccharomyces
cerevisiae) 		PF02338
(OTU) 		5 LEU A 138
GLY A 128
ILE A 184
SER A 185
ILE A 202
 None
 1.04A 3frqB-3c0rA:
undetectable		 3frqB-3c0rA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 23 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 18 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04099
(Sybindin)
PF04099
(Sybindin) 		5 GLY C  73
LEU C  44
ILE A 131
VAL C  77
ILE C  48
 None
 1.05A 3frqB-3cueC:
undetectable		 3frqB-3cueC:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		5 LEU A 235
LEU A 151
ILE A 197
VAL A  81
ILE A  78
 None
 0.83A 3frqB-3cyvA:
undetectable		 3frqB-3cyvA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		6 LEU A 250
GLY A  87
VAL A 113
LEU A 125
ILE A  98
VAL A 149
 NAD  A 450 (-3.7A)
NAD  A 450 (-4.1A)
None
None
None
None
 1.49A 3frqB-3f4bA:
undetectable		 3frqB-3f4bA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX5

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 289
LEU A 149
ILE A 262
VAL A 183
ILE A 220
 None
 0.97A 3frqB-3fe2A:
undetectable		 3frqB-3fe2A:
26.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		12 THR A  17
LEU A  20
GLY A  62
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
ILE A 105
SER A 106
VAL A 126
ILE A 150
 ERY  A 195 (-4.4A)
None
ERY  A 195 ( 4.1A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 ( 4.3A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
 0.50A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuy PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX53

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 426
LEU A 286
ILE A 399
VAL A 321
ILE A 357
 None
 1.03A 3frqB-3iuyA:
undetectable		 3frqB-3iuyA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro NUCLEOPORIN NUP84

(Saccharomyces
cerevisiae) 		PF04121
(Nup84_Nup100) 		5 VAL C  78
LEU C 355
SER C 349
ILE C 388
ILE C 359
 None
 1.07A 3frqB-3jroC:
undetectable		 3frqB-3jroC:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 212
GLY B 251
LEU B 288
SER B 224
ILE B 295
 None
 1.05A 3frqB-3ogkB:
undetectable		 3frqB-3ogkB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oss TYPE 2 SECRETION
SYSTEM, SECRETIN
GSPD

(Escherichia
coli) 		PF03958
(Secretin_N) 		5 LEU D  55
GLY D 132
SER D 150
ILE D  41
SER D  40
 None
 1.02A 3frqB-3ossD:
undetectable		 3frqB-3ossD:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 212
GLY A 245
LEU A 299
ILE A 240
ILE A 266
 None
 0.90A 3frqB-3ozyA:
undetectable		 3frqB-3ozyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pih UVRABC SYSTEM
PROTEIN A

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		5 LEU A  14
GLY A 543
VAL A 797
SER A  38
ILE A 669
 None
None
None
PPV  A1002 (-2.7A)
None
 0.98A 3frqB-3pihA:
undetectable		 3frqB-3pihA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		5 GLY A 268
LEU A  35
MET A 260
VAL A  39
ILE A 209
 None
 1.06A 3frqB-3pkjA:
0.1		 3frqB-3pkjA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnt IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 THR B  95
LEU B  96
VAL B  21
ILE B 118
SER B 117
 None
 0.85A 3frqB-3pntB:
undetectable		 3frqB-3pntB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pqd L-LACTATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 235
TYR A  20
LEU A 119
SER A 152
ILE A 144
 None
 1.04A 3frqB-3pqdA:
undetectable		 3frqB-3pqdA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 203
LEU A 207
GLY A 165
ILE A 189
ILE A  54
 None
 0.99A 3frqB-3q4dA:
undetectable		 3frqB-3q4dA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb2 IMMUNITY FACTOR FOR
SPN

(Streptococcus
pyogenes) 		PF16718
(IFS) 		5 THR A  95
LEU A  96
VAL A  21
ILE A 118
SER A 117
 None
 0.95A 3frqB-3qb2A:
undetectable		 3frqB-3qb2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk FUSION OF UREASE
BETA AND GAMMA
SUBUNITS
UREASE SUBUNIT BETA
2

(Helicobacter
mustelae;
Helicobacter
mustelae) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 GLY A 191
LEU C  42
SER A 170
ILE A 195
ILE C  50
 None
 1.06A 3frqB-3qgkA:
undetectable		 3frqB-3qgkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 5 THR A  16
LEU A  19
VAL A 229
MET A 153
VAL A 257
 UDP  A 400 (-3.0A)
None
None
None
None
 0.95A 3frqB-3qkwA:
undetectable		 3frqB-3qkwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 126
GLY A 115
LEU A 362
ILE A 281
ILE A  29
 None
 0.85A 3frqB-3sjnA:
undetectable		 3frqB-3sjnA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tv2 FUMARATE HYDRATASE,
CLASS II

(Burkholderia
pseudomallei) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 GLY A 491
VAL A 487
LEU A 421
VAL A 509
ILE A 296
 None
 0.96A 3frqB-3tv2A:
2.0		 3frqB-3tv2A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiq KOJIBIOSE
PHOSPHORYLASE

(Caldicellulosiruptor
saccharolyticus) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 327
GLY A 680
LEU A 663
SER A 316
ILE A  10
 None
 0.98A 3frqB-3wiqA:
undetectable		 3frqB-3wiqA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 THR A 149
LEU A 150
VAL A 244
ILE A 236
VAL A   8
 None
 1.03A 3frqB-3wsvA:
undetectable		 3frqB-3wsvA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b67 L-ORNITHINE N5
MONOOXYGENASE

(Aspergillus
fumigatus) 		PF13434
(K_oxygenase) 		5 VAL A 188
LEU A 415
ILE A  79
VAL A 168
ILE A 210
 None
None
None
FAD  A1492 (-3.8A)
FAD  A1492 (-3.5A)
 1.05A 3frqB-4b67A:
undetectable		 3frqB-4b67A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		6 GLY A1118
LEU A1127
SER A1126
ILE A1061
SER A1057
ILE A1179
 None
 1.42A 3frqB-4bocA:
undetectable		 3frqB-4bocA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 LEU A 497
LEU A 569
ILE A 501
VAL A 565
ILE A 591
 None
 1.04A 3frqB-4bsnA:
2.3		 3frqB-4bsnA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2l ENDO-XYLOGALACTURONA
N HYDROLASE A

(Aspergillus
tubingensis) 		PF00295
(Glyco_hydro_28) 		5 GLY A  61
LEU A 162
ILE A  53
VAL A 117
ILE A 156
 None
 0.92A 3frqB-4c2lA:
undetectable		 3frqB-4c2lA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 VAL B 261
LEU B 140
ILE B 160
VAL B 237
ILE B 136
 None
 0.86A 3frqB-4ccyB:
undetectable		 3frqB-4ccyB:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 GLY A  25
VAL A  30
LEU A  18
ILE A  61
ILE A  13
 STU  A1550 (-3.8A)
None
None
None
None
 0.98A 3frqB-4cfhA:
undetectable		 3frqB-4cfhA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 GLY A  85
LEU A 367
ILE A  76
VAL A  34
ILE A 121
 None
 1.05A 3frqB-4dioA:
undetectable		 3frqB-4dioA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		5 THR A 242
VAL A 319
TYR A 322
SER A 182
VAL A 255
 None
 0.93A 3frqB-4ej0A:
undetectable		 3frqB-4ej0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 LEU A 263
GLY A 317
LEU A 355
ILE A 278
ILE A 231
 None
 1.07A 3frqB-4ifqA:
undetectable		 3frqB-4ifqA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2f GLUTATHIONE
S-TRANSFERASE

(Ricinus
communis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A 202
GLY A 160
SER A  67
ILE A 198
VAL A  98
 None
 0.95A 3frqB-4j2fA:
undetectable		 3frqB-4j2fA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 134
TYR A 126
SER A  49
ILE A 390
SER A  43
 None
None
NAD  A 403 ( 3.0A)
None
None
 1.06A 3frqB-4jlwA:
undetectable		 3frqB-4jlwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k25 PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN QRI7,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00814
(Peptidase_M22) 		5 GLY A 325
TYR A 353
LEU A 336
SER A 201
ILE A 300
 None
 1.03A 3frqB-4k25A:
undetectable		 3frqB-4k25A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3w LIPASE

(Rhizopus
microsporus) 		PF01764
(Lipase_3) 		5 GLY A 170
VAL A 202
SER A 250
ILE A 167
ILE A  41
 None
 1.04A 3frqB-4l3wA:
undetectable		 3frqB-4l3wA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 THR A  41
GLY A 279
VAL A 281
LEU A 345
ILE A  50
 None
 1.01A 3frqB-4lz6A:
undetectable		 3frqB-4lz6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4obs ALPHA-L-IDURONIDASE

(Homo sapiens) 		PF01229
(Glyco_hydro_39) 		5 GLY A 391
VAL A  80
LEU A 126
ILE A 326
VAL A  77
 None
 0.84A 3frqB-4obsA:
undetectable		 3frqB-4obsA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofs PROBABLE LIPOAMIDE
ACYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00198
(2-oxoacid_dh) 		5 GLY A  97
LEU A 189
ILE A 122
SER A 123
VAL A 175
 None
 1.04A 3frqB-4ofsA:
undetectable		 3frqB-4ofsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		5 GLY A 421
LEU A 284
ILE A 305
VAL A 383
ILE A 278
 ANP  A 501 (-4.8A)
None
ALY  A 508 ( 4.6A)
None
None
 1.04A 3frqB-4q6gA:
undetectable		 3frqB-4q6gA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 LEU A 222
GLY A 237
LEU A 100
VAL A 359
ILE A 103
 None
 1.05A 3frqB-4w87A:
undetectable		 3frqB-4w87A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		5 THR A 174
LEU A 173
LEU A 160
ILE A 118
ILE A  49
 AZM  A 302 (-3.3A)
AZM  A 302 (-3.7A)
None
PE8  A 303 (-4.9A)
None
 1.02A 3frqB-4x5sA:
undetectable		 3frqB-4x5sA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zaj ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 LEU A 522
GLY A 576
VAL A 572
ILE A 516
ILE A   4
 None
 1.03A 3frqB-4zajA:
undetectable		 3frqB-4zajA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 GLY A  58
VAL A  26
LEU A 108
ILE A  61
VAL A  77
 None
 1.00A 3frqB-4zhjA:
undetectable		 3frqB-4zhjA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxl O-GLCNACASE NAGJ

(Clostridium
perfringens) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 VAL A 179
LEU A 419
ILE A 184
VAL A 423
ILE A 375
 None
 1.07A 3frqB-4zxlA:
undetectable		 3frqB-4zxlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 THR A 322
LEU A 449
ILE A 469
VAL A 422
ILE A 480
 None
 1.03A 3frqB-5affA:
2.0		 3frqB-5affA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 THR A 613
LEU A 612
LEU A1349
ILE A 477
ILE A1331
 None
 0.98A 3frqB-5amqA:
undetectable		 3frqB-5amqA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 5 LEU A 287
GLY A 480
ILE A 393
SER A 394
ILE A 534
 None
None
NAD  A 702 (-4.3A)
None
None
 0.99A 3frqB-5bjxA:
undetectable		 3frqB-5bjxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdd STRUCTURAL
POLYPROTEIN, VP2

(Israeli acute
paralysis virus) 		PF00073
(Rhv) 		5 GLY C 225
VAL C 145
LEU C 139
MET C 149
ILE C 237
 None
 1.03A 3frqB-5cddC:
undetectable		 3frqB-5cddC:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 GLY A 430
LEU A 148
SER A 151
SER A 410
VAL A 385
 None
 1.00A 3frqB-5d2eA:
undetectable		 3frqB-5d2eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A  30
GLY A  33
LEU A  60
VAL A  55
ILE A  89
 None
 0.88A 3frqB-5dt9A:
0.1		 3frqB-5dt9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASN A  71
ASN A  41
HIS A 102
ALA A  66
 None
 1.17A 3frqB-1bqbA:
0.0		 3frqB-1bqbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btn BETA-SPECTRIN

(Mus musculus) 		PF15410
(PH_9) 		4 ASN A  15
ASN A  84
HIS A   9
ALA A  18
 None
 1.00A 3frqB-1btnA:
undetectable		 3frqB-1btnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 ASN P 222
ASN P 141
HIS P 194
ALA P 210
 None
SO4  P1001 (-3.5A)
SO4  P1001 (-4.1A)
None
 1.41A 3frqB-1cf2P:
0.0		 3frqB-1cf2P:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.28A 3frqB-1ciyA:
1.2		 3frqB-1ciyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 ASN A 212
ASN A 201
HIS A 244
ALA A 209
 None
 1.28A 3frqB-1cjaA:
0.1		 3frqB-1cjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coj PROTEIN (SUPEROXIDE
DISMUTASE)

(Aquifex
pyrophilus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ASN A  74
TYR A  35
ASN A 152
ALA A 147
 None
 1.30A 3frqB-1cojA:
0.0		 3frqB-1cojA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 169
ARG A 171
ASN A 180
ALA A 163
 None
 1.25A 3frqB-1db3A:
undetectable		 3frqB-1db3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN A 477
ARG B 384
ASN B 379
ALA A 272
 None
 1.28A 3frqB-1e6vA:
0.3		 3frqB-1e6vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.15A 3frqB-1e6yA:
0.4		 3frqB-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 ASN A 268
ASN A 189
HIS A 325
ALA A 284
 CA  A4903 (-3.0A)
CL  A4901 (-3.8A)
CUZ  A4801 ( 3.3A)
None
 1.44A 3frqB-1fwxA:
undetectable		 3frqB-1fwxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASN A 319
ARG A 102
HIS A  10
ALA A 355
 None
 1.25A 3frqB-1kwgA:
undetectable		 3frqB-1kwgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 198
ARG A 200
ASN A 209
ALA A 192
 None
 1.21A 3frqB-1n7gA:
undetectable		 3frqB-1n7gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 LYS A 193
ASN A 398
HIS A  66
ALA A  62
 None
None
None
2PG  A 801 (-3.4A)
 1.01A 3frqB-1o99A:
undetectable		 3frqB-1o99A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG O  14
ASN O  15
HIS O  53
ALA O  52
 None
 1.14A 3frqB-1obfO:
undetectable		 3frqB-1obfO:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IG ALPHA-1 CHAIN C
REGION

(Homo sapiens) 		PF00047
(ig)
PF07654
(C1-set) 		4 ASN A 316
ARG A 250
HIS A 436
ALA A 438
 None
 1.45A 3frqB-1ow0A:
undetectable		 3frqB-1ow0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdu CASPASE-8
ALPHA-CHAIN

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ASN A 180
ARG A 179
ASN A 169
HIS A 204
 None
 1.22A 3frqB-1qduA:
undetectable		 3frqB-1qduA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		4 LYS A 249
TYR A 201
HIS A 233
ALA A 221
 None
 1.35A 3frqB-1snzA:
undetectable		 3frqB-1snzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		4 LYS A 125
ASN A 153
ASN A 274
ALA A 188
 None
 1.42A 3frqB-1svvA:
undetectable		 3frqB-1svvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major) 		PF01212
(Beta_elim_lyase) 		4 LYS A 125
ASN A 153
ASN A 298
ALA A 188
 None
 1.31A 3frqB-1svvA:
undetectable		 3frqB-1svvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 ASN A  93
ARG A 132
ASN A 133
ALA A 160
 None
 1.18A 3frqB-1t5oA:
1.7		 3frqB-1t5oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V

(Canis lupus) 		PF00211
(Guanylate_cyc) 		4 ASN A 389
ASN A 537
HIS A 457
ALA A 456
 None
 1.25A 3frqB-1tl7A:
undetectable		 3frqB-1tl7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp2 PUTATIVE XANTHOSINE
TRIPHOSPHATE
PYROPHOSPHATASE/HAM1
PROTEIN HOMOLOG

(Thermotoga
maritima) 		PF01725
(Ham1p_like) 		4 TYR A 150
ARG A 176
ASN A  12
ALA A  85
 None
 1.31A 3frqB-1vp2A:
undetectable		 3frqB-1vp2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkg MAJOR MITE FECAL
ALLERGEN DER P 1

(Dermatophagoides
pteronyssinus) 		PF00112
(Peptidase_C1) 		4 TYR A 176
ASN A 270
HIS A 250
ALA A 114
 None
None
None
GOL  A 602 (-3.9A)
 1.18A 3frqB-1xkgA:
undetectable		 3frqB-1xkgA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 TYR A 191
ASN A 283
HIS A 263
ALA A 124
 None
 1.05A 3frqB-2c0yA:
undetectable		 3frqB-2c0yA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 LYS A 757
ASN A 702
HIS A 522
ALA A 511
 None
 1.22A 3frqB-2o2qA:
undetectable		 3frqB-2o2qA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpn PERIPLASMIC
SUBSTRATE BINDING
PROTEIN

(Halomonas
elongata) 		PF03480
(DctP) 		4 ASN A  61
TYR A   5
HIS A 241
ALA A  21
 None
 1.39A 3frqB-2vpnA:
undetectable		 3frqB-2vpnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		4 ASN A 315
TYR A 313
ARG A 353
HIS A 366
 None
 1.30A 3frqB-2xy1A:
undetectable		 3frqB-2xy1A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyc NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 ASN A 315
TYR A 313
ARG A 353
HIS A 366
 None
 1.22A 3frqB-2xycA:
undetectable		 3frqB-2xycA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ASN A 342
ASN A 378
HIS A 381
ALA A 337
 None
 1.41A 3frqB-3aqpA:
undetectable		 3frqB-3aqpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ARG A 469
ASN A 466
HIS A 435
ALA A 434
 None
 1.07A 3frqB-3decA:
undetectable		 3frqB-3decA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 ASN A 174
ARG A 133
ASN A 178
ALA A 167
 None
 1.45A 3frqB-3emkA:
1.6		 3frqB-3emkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 334
ARG A  47
HIS A  19
ALA A 186
 None
 1.10A 3frqB-3enkA:
undetectable		 3frqB-3enkA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epd PROTEIN VP2
POLIOVIRUS RECEPTOR

(Enterovirus C;
Homo sapiens) 		PF00073
(Rhv)
PF07686
(V-set)
PF08205
(C2-set_2) 		4 LYS 2 162
TYR 2 141
HIS R  60
ALA R 101
 None
 1.13A 3frqB-3epd2:
undetectable		 3frqB-3epd2:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		4 ASN A 270
TYR A 264
ASN A 388
ALA A 260
 None
 1.41A 3frqB-3fdhA:
undetectable		 3frqB-3fdhA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		4 LYS A 534
ARG A 316
ASN A 314
ALA A 272
 None
 1.34A 3frqB-3fipA:
undetectable		 3frqB-3fipA:
15.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		7 LYS A  21
ASN A 102
TYR A 103
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 CL  A 198 ( 4.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.53A 3frqB-3frqA:
29.8		 3frqB-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 ASN A 180
TYR A 152
ARG A 230
ALA A 145
 None
 1.40A 3frqB-3fw6A:
undetectable		 3frqB-3fw6A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ASN A 328
TYR A 319
ARG A 282
ALA A 364
 None
 1.38A 3frqB-3g4gA:
undetectable		 3frqB-3g4gA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG A  14
ASN A  15
HIS A  53
ALA A  52
 None
 1.12A 3frqB-3gnqA:
undetectable		 3frqB-3gnqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B
DNA-DIRECTED RNA
POLYMERASE, SUBUNIT
G (RPOG)

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF16992
(RNA_pol_RpbG) 		4 LYS G  24
TYR A 507
HIS B 913
ALA A 733
 None
 1.43A 3frqB-3hkzG:
undetectable		 3frqB-3hkzG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i09 PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Burkholderia
mallei) 		PF13458
(Peripla_BP_6) 		4 TYR A 173
ASN A 123
HIS A 142
ALA A 128
 AAE  A 501 (-4.5A)
None
None
None
 1.23A 3frqB-3i09A:
undetectable		 3frqB-3i09A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		4 TYR A2020
ASN A1952
HIS A2026
ALA A2023
 None
 1.20A 3frqB-3ilsA:
0.1		 3frqB-3ilsA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN G

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		4 ASN J  39
ARG D  62
ASN D  36
ALA J   6
 U  C  97 ( 3.1A)
U  C  97 ( 3.2A)
U  C  98 ( 4.0A)
None
 1.43A 3frqB-3jb9J:
undetectable		 3frqB-3jb9J:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
 None
 1.40A 3frqB-3k7lA:
undetectable		 3frqB-3k7lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
 None
 1.40A 3frqB-3k7nA:
undetectable		 3frqB-3k7nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 ASN A 176
ARG A 135
ASN A 180
ALA A 169
 None
 1.45A 3frqB-3lylA:
undetectable		 3frqB-3lylA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtw L-ARGININE
CARBOXYPEPTIDASE
CC2672

(Caulobacter
vibrioides) 		PF01979
(Amidohydro_1) 		4 ASN A 297
TYR A 296
ASN A 308
ALA A 303
 M3R  A 430 (-3.7A)
None
None
None
 1.34A 3frqB-3mtwA:
undetectable		 3frqB-3mtwA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		4 ASN A  38
ASN A 204
HIS A 174
ALA A  42
 None
 1.44A 3frqB-3pnrA:
undetectable		 3frqB-3pnrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		4 TYR A 106
ASN A 204
HIS A 174
ALA A  42
 None
 1.15A 3frqB-3pnrA:
undetectable		 3frqB-3pnrA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfo PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF12850
(Metallophos_2) 		4 LYS A 133
TYR A 162
ARG A 137
HIS A 141
 None
None
AMP  A 263 (-3.3A)
AMP  A 263 (-4.1A)
 1.43A 3frqB-3qfoA:
undetectable		 3frqB-3qfoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		4 ASN A 256
ASN A 282
HIS A 260
ALA A 214
 None
None
ZN  A 355 (-3.2A)
None
 1.44A 3frqB-3qm3A:
undetectable		 3frqB-3qm3A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 ASN A  41
ASN A   9
HIS A 223
ALA A 191
 None
None
ZN  A 302 (-3.5A)
None
 1.34A 3frqB-3rpcA:
undetectable		 3frqB-3rpcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 370
ARG A 315
ASN A 314
HIS A 344
 SO4  A 414 (-4.8A)
SO4  A 414 (-3.7A)
None
None
 1.35A 3frqB-3sszA:
undetectable		 3frqB-3sszA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ARG A 702
ASN A 701
HIS A 669
ALA A 626
 None
AMP  A 747 (-3.9A)
None
None
 1.29A 3frqB-3ttfA:
undetectable		 3frqB-3ttfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ARG A 106
ASN A 113
HIS A  85
ALA A  90
 None
 1.40A 3frqB-3ttsA:
undetectable		 3frqB-3ttsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ASN A 180
TYR A 181
ASN A 554
HIS A 367
 None
None
FE2  A 701 (-3.8A)
FE2  A 701 (-3.4A)
 1.13A 3frqB-3v98A:
0.9		 3frqB-3v98A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 ASN A  16
ARG A 317
ASN A 319
ALA A  30
 None
 1.39A 3frqB-3vv3A:
0.5		 3frqB-3vv3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis) 		PF00337
(Gal-bind_lectin) 		4 ASN A 125
ARG A  32
ASN A  31
ALA A  27
 MLA  A 203 (-3.9A)
GAL  A 202 (-2.8A)
None
None
 1.30A 3frqB-3wucA:
undetectable		 3frqB-3wucA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASN A 394
ARG A 419
HIS A 520
ALA A 518
 None
 1.20A 3frqB-4a1oA:
undetectable		 3frqB-4a1oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.26A 3frqB-4arxA:
undetectable		 3frqB-4arxA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASN C 249
ARG C 164
ASN C 256
ALA C 153
 SO4  C1405 (-3.5A)
None
None
None
 1.43A 3frqB-4b3iC:
undetectable		 3frqB-4b3iC:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ASN A 175
TYR A 174
HIS A 425
ALA A 430
 None
 1.23A 3frqB-4b9yA:
undetectable		 3frqB-4b9yA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		4 TYR A 151
ARG A 178
ASN A  10
ALA A  85
 None
None
PO4  A 800 (-4.9A)
None
 1.27A 3frqB-4bnqA:
undetectable		 3frqB-4bnqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 LYS A 594
TYR A 551
HIS A 466
ALA A 507
 None
 1.44A 3frqB-4bsnA:
2.6		 3frqB-4bsnA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 ARG A  55
ASN A  56
HIS A  32
ALA A  33
 NAG  A 603 (-3.6A)
None
None
None
 1.26A 3frqB-4cyfA:
undetectable		 3frqB-4cyfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus) 		PF03446
(NAD_binding_2) 		4 ASN A  90
ASN A 110
HIS A 133
ALA A 122
 None
 1.27A 3frqB-4d3dA:
undetectable		 3frqB-4d3dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfs GLYCOSIDE HYDROLASE,
FAMILY 16

(Thermotoga
petrophila) 		PF00722
(Glyco_hydro_16) 		4 ASN A  45
TYR A 231
ASN A  34
HIS A  36
 None
 0.98A 3frqB-4dfsA:
undetectable		 3frqB-4dfsA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fa0 GROUP XVI
PHOSPHOLIPASE A1/A2

(Homo sapiens) 		PF04970
(LRAT) 		4 ASN A  77
ARG A  22
HIS A  23
ALA A  25
 None
 1.38A 3frqB-4fa0A:
undetectable		 3frqB-4fa0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 ASN A 242
ASN A 710
HIS A 706
ALA A 246
 None
 0.92A 3frqB-4fyeA:
undetectable		 3frqB-4fyeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ASN A 387
ARG A 251
HIS A 331
ALA A 384
 None
 1.24A 3frqB-4j0wA:
undetectable		 3frqB-4j0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ASN A 370
ASN A 294
HIS A 350
ALA A 274
 None
 1.36A 3frqB-4k90A:
undetectable		 3frqB-4k90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcv DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		4 LYS A 221
ASN A 225
ARG A 181
HIS A 169
 None
None
BME  A 302 (-4.5A)
SO4  A 301 (-4.4A)
 1.19A 3frqB-4lcvA:
undetectable		 3frqB-4lcvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 ASN A  97
ARG A  17
ASN A  19
ALA A  90
 None
 1.09A 3frqB-4oetA:
undetectable		 3frqB-4oetA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Homo sapiens) 		PF01704
(UDPGP) 		4 LYS A  33
TYR A 193
ASN A 346
ALA A 228
 None
 1.44A 3frqB-4r7pA:
undetectable		 3frqB-4r7pA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 TYR A 349
ARG A  84
ASN A  85
ALA A  67
 None
None
DDZ  A  64 ( 4.0A)
DDZ  A  64 ( 3.7A)
 1.39A 3frqB-4uphA:
undetectable		 3frqB-4uphA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ASN A 143
ASN A 172
HIS A 241
ALA A 245
 None
 1.43A 3frqB-4wpzA:
undetectable		 3frqB-4wpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		4 TYR A 228
ARG A 160
ASN A 157
HIS A 247
 None
PAF  A 401 (-3.0A)
PAF  A 401 (-3.6A)
PAF  A 401 (-4.1A)
 1.41A 3frqB-4xeqA:
undetectable		 3frqB-4xeqA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01

(Human
immunodeficiency
virus 1;
Homo sapiens) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 ASN G 462
ARG G 456
ASN G 280
ALA H  60
 NAG  G 512 (-4.5A)
None
None
None
 1.21A 3frqB-4ydiG:
undetectable		 3frqB-4ydiG:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		4 TYR A  79
ASN A 169
HIS A 124
ALA A  20
 None
None
BG6  A 501 (-4.2A)
BG6  A 501 ( 4.9A)
 1.29A 3frqB-4zfmA:
undetectable		 3frqB-4zfmA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 ASN A1684
TYR A1663
ARG A1603
HIS A1649
ALA A1679
 None
 1.29A 3frqB-5a22A:
undetectable		 3frqB-5a22A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		4 TYR A1663
ARG A1606
HIS A1649
ALA A1679
 None
 1.10A 3frqB-5a22A:
undetectable		 3frqB-5a22A:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6c G-PROTEIN-SIGNALING
MODULATOR 2, AFADIN

(Homo sapiens) 		PF13176
(TPR_7)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 TYR A 375
ARG A 316
HIS A 301
ALA A 275
 None
 1.44A 3frqB-5a6cA:
undetectable		 3frqB-5a6cA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 ASN B 125
ARG B 262
HIS B 181
ALA B 189
 None
 1.33A 3frqB-5cwwB:
undetectable		 3frqB-5cwwB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff9 NOROXOMARITIDINE/NOR
CRAUGSODINE
REDUCTASE

(Narcissus
pseudonarcissus) 		PF13561
(adh_short_C2) 		4 ASN A 134
TYR A 175
ASN A 183
ALA A 204
 None
NAP  A 301 (-4.5A)
SO4  A 302 (-4.3A)
None
 1.36A 3frqB-5ff9A:
undetectable		 3frqB-5ff9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		4 ASN A 199
TYR A 497
ARG A  96
ALA A 192
 None
 1.41A 3frqB-5fhzA:
undetectable		 3frqB-5fhzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP4

(Saccharomyces
cerevisiae) 		PF14382
(ECR1_N)
PF15985
(KH_6) 		4 ASN H 142
TYR H 281
HIS H 111
ALA H 171
 None
 1.08A 3frqB-5g06H:
undetectable		 3frqB-5g06H:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 LYS A 458
ASN A 490
TYR A 488
ASN A 533
 None
 1.43A 3frqB-5hmpA:
0.3		 3frqB-5hmpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASN A  97
TYR A 618
ASN A  43
HIS A 206
 FAD  A 702 (-4.9A)
None
None
None
 1.34A 3frqB-5i68A:
undetectable		 3frqB-5i68A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		4 TYR A 282
ARG A 140
HIS A 113
ALA A 148
 None
 1.27A 3frqB-5l44A:
undetectable		 3frqB-5l44A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN
PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
PF08084
(PROCT) 		4 ASN B2055
ARG B2057
ASN A1059
ALA B2050
 None
 1.20A 3frqB-5m59B:
undetectable		 3frqB-5m59B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
PF02662
(FlpD) 		4 ARG A 100
ASN A  98
HIS A 102
ALA D  21
 SF4  A 705 (-4.1A)
None
None
None
 1.28A 3frqB-5odrA:
undetectable		 3frqB-5odrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		4 ASN A 263
ARG A 267
ASN A 242
ALA A 239
 None
NO2  A 403 (-3.7A)
None
None
 1.33A 3frqB-5tr7A:
0.8		 3frqB-5tr7A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3

(Homo sapiens) 		no annotation 4 ASN A   9
ARG A  75
HIS A  19
ALA A  12
 None
 0.97A 3frqB-5ukeA:
undetectable		 3frqB-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4b ADENOSYLHOMOCYSTEINA
SE

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 LYS A 426
ASN A 360
HIS A 398
ALA A 397
 None
 1.38A 3frqB-5w4bA:
undetectable		 3frqB-5w4bA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ywo 2F2 HEAVY CHAIN

(Mus musculus) 		no annotation 4 TYR N  27
ARG N 101
HIS N  35
ALA N  97
 None
 1.39A 3frqB-5ywoN:
undetectable		 3frqB-5ywoN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 4 TYR 4 413
ARG 4 553
HIS 4 371
ALA 4 370
 None
 1.06A 3frqB-5zvs4:
undetectable		 3frqB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 4 ASN A 205
TYR A 503
ARG A 102
ALA A 198
 None
 1.36A 3frqB-6b5iA:
undetectable		 3frqB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza A
virus) 		no annotation 4 ASN B 225
TYR B 129
ARG B 126
ALA B 142
 None
 1.40A 3frqB-6evjB:
undetectable		 3frqB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gpl GDP-MANNOSE 4,6
DEHYDRATASE

(Homo sapiens) 		no annotation 4 ASN B 192
ARG B 194
ASN B 203
ALA B 186
 None
EDO  B 405 ( 3.7A)
None
None
 1.20A 3frqB-6gplB:
undetectable		 3frqB-6gplB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gzp NANOBODY

(Lama glama) 		no annotation 4 ASN A  33
TYR A 100
ARG A  71
ALA A  49
 None
 1.07A 3frqB-6gzpA:
undetectable		 3frqB-6gzpA:
undetectable