SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRQ_A_ERYA195_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
4 ASN A  71
ASN A  41
HIS A 102
ALA A  66
None
1.14A 3frqA-1bqbA:
0.0
3frqA-1bqbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btn BETA-SPECTRIN

(Mus musculus)
PF15410
(PH_9)
4 ASN A  15
ASN A  84
HIS A   9
ALA A  18
None
0.98A 3frqA-1btnA:
undetectable
3frqA-1btnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)


(Methanothermus
fervidus)
no annotation 4 ASN P 222
ASN P 141
HIS P 194
ALA P 210
None
SO4  P1001 (-3.5A)
SO4  P1001 (-4.1A)
None
1.40A 3frqA-1cf2P:
0.0
3frqA-1cf2P:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
None
1.30A 3frqA-1ciyA:
1.1
3frqA-1ciyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)


(Physarum
polycephalum)
PF09192
(Act-Frag_cataly)
4 ASN A 212
ASN A 201
HIS A 244
ALA A 209
None
1.26A 3frqA-1cjaA:
0.1
3frqA-1cjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE


(Escherichia
coli)
PF16363
(GDP_Man_Dehyd)
4 ASN A 169
ARG A 171
ASN A 180
ALA A 163
None
1.26A 3frqA-1db3A:
undetectable
3frqA-1db3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanopyrus
kandleri;
Methanopyrus
kandleri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 ASN A 477
ARG B 384
ASN B 379
ALA A 272
None
1.27A 3frqA-1e6vA:
0.5
3frqA-1e6vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT


(Methanosarcina
barkeri;
Methanosarcina
barkeri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N)
4 ASN A1494
ARG B2381
ASN B2376
ALA A1283
AGM  A1285 ( 3.7A)
None
None
None
1.13A 3frqA-1e6yA:
0.5
3frqA-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR


(Escherichia
coli)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 ASN A 534
ARG A 464
ASN A 441
ALA A 468
None
1.48A 3frqA-1fepA:
undetectable
3frqA-1fepA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE


(Paracoccus
denitrificans)
PF13473
(Cupredoxin_1)
4 ASN A 268
ASN A 189
HIS A 325
ALA A 284
CA  A4903 (-3.0A)
CL  A4901 (-3.8A)
CUZ  A4801 ( 3.3A)
None
1.44A 3frqA-1fwxA:
0.0
3frqA-1fwxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 ASN A 319
ARG A 102
HIS A  10
ALA A 355
None
1.21A 3frqA-1kwgA:
undetectable
3frqA-1kwgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE


(Arabidopsis
thaliana)
PF16363
(GDP_Man_Dehyd)
4 ASN A 198
ARG A 200
ASN A 209
ALA A 192
None
1.23A 3frqA-1n7gA:
undetectable
3frqA-1n7gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME


(Ascaris suum)
PF00390
(malic)
PF03949
(Malic_M)
4 ASN A 275
ASN A 374
HIS A 377
ALA A 328
NAI  A 920 (-3.1A)
None
None
NAI  A 920 (-3.9A)
1.45A 3frqA-1o0sA:
undetectable
3frqA-1o0sA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Achromobacter
xylosoxidans)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ARG O  14
ASN O  15
HIS O  53
ALA O  52
None
1.13A 3frqA-1obfO:
undetectable
3frqA-1obfO:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IG ALPHA-1 CHAIN C
REGION


(Homo sapiens)
PF00047
(ig)
PF07654
(C1-set)
4 ASN A 316
ARG A 250
HIS A 436
ALA A 438
None
1.43A 3frqA-1ow0A:
undetectable
3frqA-1ow0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdu CASPASE-8
ALPHA-CHAIN


(Homo sapiens)
PF00656
(Peptidase_C14)
4 ASN A 180
ARG A 179
ASN A 169
HIS A 204
None
1.22A 3frqA-1qduA:
undetectable
3frqA-1qduA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA


(Archaeoglobus
fulgidus)
PF01008
(IF-2B)
4 ASN A  93
ARG A 132
ASN A 133
ALA A 160
None
1.16A 3frqA-1t5oA:
1.7
3frqA-1t5oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V


(Canis lupus)
PF00211
(Guanylate_cyc)
4 ASN A 389
ASN A 537
HIS A 457
ALA A 456
None
1.25A 3frqA-1tl7A:
1.5
3frqA-1tl7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME


(Aeropyrum
pernix)
PF00326
(Peptidase_S9)
4 ASN A 284
ASN A 396
HIS A 367
ALA A 372
None
1.47A 3frqA-2qzpA:
0.9
3frqA-2qzpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 ASN A 342
ASN A 378
HIS A 381
ALA A 337
None
1.40A 3frqA-3aqpA:
undetectable
3frqA-3aqpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981)
4 ARG A 469
ASN A 466
HIS A 435
ALA A 434
None
1.07A 3frqA-3decA:
undetectable
3frqA-3decA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE


(Brucella
melitensis)
PF13561
(adh_short_C2)
4 ASN A 174
ARG A 133
ASN A 178
ALA A 167
None
1.46A 3frqA-3emkA:
undetectable
3frqA-3emkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE


(Burkholderia
pseudomallei)
PF16363
(GDP_Man_Dehyd)
4 ASN A 334
ARG A  47
HIS A  19
ALA A 186
None
1.09A 3frqA-3enkA:
undetectable
3frqA-3enkA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)


(Escherichia
coli)
PF00440
(TetR_N)
5 ASN A 102
ARG A 122
ASN A 123
HIS A 147
ALA A 151
ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
0.00A 3frqA-3frqA:
32.2
3frqA-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I


(Burkholderia
pseudomallei)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
4 ARG A  14
ASN A  15
HIS A  53
ALA A  52
None
1.10A 3frqA-3gnqA:
undetectable
3frqA-3gnqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN G


(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe)
PF01423
(LSM)
PF01423
(LSM)
4 ASN J  39
ARG D  62
ASN D  36
ALA J   6
U  C  97 ( 3.1A)
U  C  97 ( 3.2A)
U  C  98 ( 4.0A)
None
1.43A 3frqA-3jb9J:
undetectable
3frqA-3jb9J:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
None
1.40A 3frqA-3k7lA:
undetectable
3frqA-3k7lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
None
1.39A 3frqA-3k7nA:
undetectable
3frqA-3k7nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
4 ASN B 539
ASN B 218
HIS B 239
ALA B 679
None
1.15A 3frqA-3l91B:
undetectable
3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
4 ASN B 539
ASN B 237
HIS B 239
ALA B 679
None
1.30A 3frqA-3l91B:
undetectable
3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Francisella
tularensis)
PF13561
(adh_short_C2)
4 ASN A 176
ARG A 135
ASN A 180
ALA A 169
None
1.46A 3frqA-3lylA:
undetectable
3frqA-3lylA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8


(Saccharomyces
cerevisiae)
PF00443
(UCH)
PF02148
(zf-UBP)
4 ASN A 110
ARG A  28
ASN A  25
ALA A 115
None
1.45A 3frqA-3m99A:
undetectable
3frqA-3m99A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium)
PF00871
(Acetate_kinase)
4 ASN A 323
ARG A 355
ASN A 347
ALA A 326
None
1.49A 3frqA-3r9pA:
undetectable
3frqA-3r9pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE


(Veillonella
parvula)
PF12706
(Lactamase_B_2)
4 ASN A  41
ASN A   9
HIS A 223
ALA A 191
None
None
ZN  A 302 (-3.5A)
None
1.33A 3frqA-3rpcA:
undetectable
3frqA-3rpcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE


(Mesorhizobium
loti)
PF13561
(adh_short_C2)
4 ASN A 176
ARG A 135
ASN A 180
ALA A 169
None
1.39A 3frqA-3rwbA:
undetectable
3frqA-3rwbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE


(Mycobacteroides
abscessus)
PF00106
(adh_short)
4 ASN A 162
ASN A 200
HIS A 235
ALA A 273
None
1.13A 3frqA-3s55A:
undetectable
3frqA-3s55A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE


(Pseudomonas
stutzeri)
no annotation 4 ASN A 324
ASN A 241
HIS A 382
ALA A 340
CA  A 703 (-3.0A)
CL  A 704 (-3.7A)
CUK  A 702 ( 3.3A)
None
1.49A 3frqA-3sbqA:
undetectable
3frqA-3sbqA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN


(Rhodobacteraceae
bacterium KLH11)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 370
ARG A 315
ASN A 314
HIS A 344
SO4  A 414 (-4.8A)
SO4  A 414 (-3.7A)
None
None
1.34A 3frqA-3sszA:
undetectable
3frqA-3sszA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE


(Labrenzia
aggregata)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 347
ARG A 292
ASN A 291
HIS A 321
None
1.31A 3frqA-3stpA:
undetectable
3frqA-3stpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN


(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF)
4 ARG A 702
ASN A 701
HIS A 669
ALA A 626
None
AMP  A 747 (-3.9A)
None
None
1.28A 3frqA-3ttfA:
undetectable
3frqA-3ttfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
4 ARG A 106
ASN A 113
HIS A  85
ALA A  90
None
1.40A 3frqA-3ttsA:
undetectable
3frqA-3ttsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913)
PF00082
(Peptidase_S8)
4 ASN A  16
ARG A 317
ASN A 319
ALA A  30
None
1.42A 3frqA-3vv3A:
0.5
3frqA-3vv3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis)
PF00337
(Gal-bind_lectin)
4 ASN A 125
ARG A  32
ASN A  31
ALA A  27
MLA  A 203 (-3.9A)
GAL  A 202 (-2.8A)
None
None
1.28A 3frqA-3wucA:
undetectable
3frqA-3wucA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Mycobacterium
tuberculosis)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
4 ASN A 394
ARG A 419
HIS A 520
ALA A 518
None
1.22A 3frqA-4a1oA:
undetectable
3frqA-4a1oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
None
1.27A 3frqA-4arxA:
undetectable
3frqA-4arxA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA


(Mycobacterium
tuberculosis)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 ASN C 249
ARG C 164
ASN C 256
ALA C 153
SO4  C1405 (-3.5A)
None
None
None
1.41A 3frqA-4b3iC:
undetectable
3frqA-4b3iC:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens)
PF00795
(CN_hydrolase)
4 ARG A  55
ASN A  56
HIS A  32
ALA A  33
NAG  A 603 (-3.6A)
None
None
None
1.23A 3frqA-4cyfA:
0.2
3frqA-4cyfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus)
PF03446
(NAD_binding_2)
4 ASN A  90
ASN A 110
HIS A 133
ALA A 122
None
1.27A 3frqA-4d3dA:
undetectable
3frqA-4d3dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3


(Legionella
pneumophila)
no annotation 4 ASN A 242
ASN A 710
HIS A 706
ALA A 246
None
0.94A 3frqA-4fyeA:
0.0
3frqA-4fyeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2


(Homo sapiens)
PF00400
(WD40)
4 ASN A 387
ARG A 251
HIS A 331
ALA A 384
None
1.21A 3frqA-4j0wA:
undetectable
3frqA-4j0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP


(Aspergillus
fumigatus)
PF02128
(Peptidase_M36)
4 ASN A 370
ASN A 294
HIS A 350
ALA A 274
None
1.36A 3frqA-4k90A:
undetectable
3frqA-4k90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE


(Methylacidiphilum
fumariolicum)
PF13360
(PQQ_2)
4 ASN A 256
ARG A 326
ASN A 304
HIS A 323
CE  A 601 ( 3.4A)
PQQ  A 602 (-2.7A)
None
None
1.49A 3frqA-4maeA:
undetectable
3frqA-4maeA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF00496
(SBP_bac_5)
4 ASN A  97
ARG A  17
ASN A  19
ALA A  90
None
1.06A 3frqA-4oetA:
undetectable
3frqA-4oetA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae)
PF13561
(adh_short_C2)
4 ASN A 182
ARG A 141
ASN A 186
ALA A 175
None
1.40A 3frqA-4ospA:
undetectable
3frqA-4ospA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis)
PF00067
(p450)
4 ASN A 143
ASN A 172
HIS A 241
ALA A 245
None
1.41A 3frqA-4wpzA:
1.0
3frqA-4wpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01


(Human
immunodeficiency
virus 1;
Homo sapiens)
PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set)
4 ASN G 462
ARG G 456
ASN G 280
ALA H  60
NAG  G 512 (-4.5A)
None
None
None
1.23A 3frqA-4ydiG:
undetectable
3frqA-4ydiG:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum)
no annotation 4 ASN B 125
ARG B 262
HIS B 181
ALA B 189
None
1.32A 3frqA-5cwwB:
undetectable
3frqA-5cwwB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT


(Influenza A
virus)
PF00604
(Flu_PB2)
4 ASN A 510
ARG A 355
ASN A 429
HIS A 432
MGT  A1676 (-3.5A)
MGT  A1676 (-3.4A)
MGT  A1676 (-3.6A)
None
1.38A 3frqA-5fmqA:
1.0
3frqA-5fmqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY


(Homo sapiens)
PF02373
(JmjC)
4 ASN A1287
ARG A1226
ASN A1223
ALA A1275
None
1.47A 3frqA-5fxvA:
undetectable
3frqA-5fxvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN
PUTATIVE PRE-MRNA
SPLICING FACTOR


(Chaetomium
thermophilum;
Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
PF08084
(PROCT)
4 ASN B2055
ARG B2057
ASN A1059
ALA B2050
None
1.18A 3frqA-5m59B:
0.1
3frqA-5m59B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
26S PROTEASOME
REGULATORY SUBUNIT
RPN12


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF01399
(PCI)
PF08375
(Rpn3_C)
PF10075
(CSN8_PSD8_EIF3K)
4 ASN T  93
ASN S 207
HIS S 191
ALA S 195
None
1.30A 3frqA-5mpdT:
undetectable
3frqA-5mpdT:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D


(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus)
PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
PF02662
(FlpD)
4 ARG A 100
ASN A  98
HIS A 102
ALA D  21
SF4  A 705 (-4.1A)
None
None
None
1.26A 3frqA-5odrA:
undetectable
3frqA-5odrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
4 ASN A 323
ASN A   2
HIS A  23
ALA A 463
None
1.14A 3frqA-5ubkA:
undetectable
3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ


(Pseudomonas
aeruginosa)
PF01804
(Penicil_amidase)
4 ASN A 323
ASN A  21
HIS A  23
ALA A 463
None
1.29A 3frqA-5ubkA:
undetectable
3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3


(Homo sapiens)
no annotation 4 ASN A   9
ARG A  75
HIS A  19
ALA A  12
None
0.99A 3frqA-5ukeA:
undetectable
3frqA-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 4 ASN A 633
ARG A 629
ASN A 277
ALA A 678
None
1.50A 3frqA-5wugA:
undetectable
3frqA-5wugA:
undetectable