SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRQ_A_ERYA195_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bqb | PROTEIN (AUREOLYSIN) (Staphylococcusaureus) |
PF01447(Peptidase_M4)PF02868(Peptidase_M4_C) | 4 | ASN A 71ASN A 41HIS A 102ALA A 66 | None | 1.14A | 3frqA-1bqbA:0.0 | 3frqA-1bqbA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1btn | BETA-SPECTRIN (Mus musculus) |
PF15410(PH_9) | 4 | ASN A 15ASN A 84HIS A 9ALA A 18 | None | 0.98A | 3frqA-1btnA:undetectable | 3frqA-1btnA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cf2 | PROTEIN(GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE) (Methanothermusfervidus) |
no annotation | 4 | ASN P 222ASN P 141HIS P 194ALA P 210 | NoneSO4 P1001 (-3.5A)SO4 P1001 (-4.1A)None | 1.40A | 3frqA-1cf2P:0.0 | 3frqA-1cf2P:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | ASN A 194ARG A 192ASN A 138HIS A 168 | None | 1.30A | 3frqA-1ciyA:1.1 | 3frqA-1ciyA:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cja | PROTEIN(ACTIN-FRAGMINKINASE) (Physarumpolycephalum) |
PF09192(Act-Frag_cataly) | 4 | ASN A 212ASN A 201HIS A 244ALA A 209 | None | 1.26A | 3frqA-1cjaA:0.1 | 3frqA-1cjaA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1db3 | GDP-MANNOSE4,6-DEHYDRATASE (Escherichiacoli) |
PF16363(GDP_Man_Dehyd) | 4 | ASN A 169ARG A 171ASN A 180ALA A 163 | None | 1.26A | 3frqA-1db3A:undetectable | 3frqA-1db3A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNITMETHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanopyruskandleri;Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | ASN A 477ARG B 384ASN B 379ALA A 272 | None | 1.27A | 3frqA-1e6vA:0.5 | 3frqA-1e6vA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHAMETHYL-COENZYME MREDUCTASE I BETASUBUNIT (Methanosarcinabarkeri;Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N)PF02241(MCR_beta)PF02783(MCR_beta_N) | 4 | ASN A1494ARG B2381ASN B2376ALA A1283 | AGM A1285 ( 3.7A)NoneNoneNone | 1.13A | 3frqA-1e6yA:0.5 | 3frqA-1e6yA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fep | FERRIC ENTEROBACTINRECEPTOR (Escherichiacoli) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 4 | ASN A 534ARG A 464ASN A 441ALA A 468 | None | 1.48A | 3frqA-1fepA:undetectable | 3frqA-1fepA:14.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fwx | NITROUS OXIDEREDUCTASE (Paracoccusdenitrificans) |
PF13473(Cupredoxin_1) | 4 | ASN A 268ASN A 189HIS A 325ALA A 284 | CA A4903 (-3.0A) CL A4901 (-3.8A)CUZ A4801 ( 3.3A)None | 1.44A | 3frqA-1fwxA:0.0 | 3frqA-1fwxA:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | ASN A 319ARG A 102HIS A 10ALA A 355 | None | 1.21A | 3frqA-1kwgA:undetectable | 3frqA-1kwgA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7g | GDP-D-MANNOSE-4,6-DEHYDRATASE (Arabidopsisthaliana) |
PF16363(GDP_Man_Dehyd) | 4 | ASN A 198ARG A 200ASN A 209ALA A 192 | None | 1.23A | 3frqA-1n7gA:undetectable | 3frqA-1n7gA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o0s | NAD-DEPENDENT MALICENZYME (Ascaris suum) |
PF00390(malic)PF03949(Malic_M) | 4 | ASN A 275ASN A 374HIS A 377ALA A 328 | NAI A 920 (-3.1A)NoneNoneNAI A 920 (-3.9A) | 1.45A | 3frqA-1o0sA:undetectable | 3frqA-1o0sA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1obf | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Achromobacterxylosoxidans) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ARG O 14ASN O 15HIS O 53ALA O 52 | None | 1.13A | 3frqA-1obfO:undetectable | 3frqA-1obfO:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ow0 | IG ALPHA-1 CHAIN CREGION (Homo sapiens) |
PF00047(ig)PF07654(C1-set) | 4 | ASN A 316ARG A 250HIS A 436ALA A 438 | None | 1.43A | 3frqA-1ow0A:undetectable | 3frqA-1ow0A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qdu | CASPASE-8ALPHA-CHAIN (Homo sapiens) |
PF00656(Peptidase_C14) | 4 | ASN A 180ARG A 179ASN A 169HIS A 204 | None | 1.22A | 3frqA-1qduA:undetectable | 3frqA-1qduA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t5o | TRANSLATIONINITIATION FACTOREIF2B, SUBUNIT DELTA (Archaeoglobusfulgidus) |
PF01008(IF-2B) | 4 | ASN A 93ARG A 132ASN A 133ALA A 160 | None | 1.16A | 3frqA-1t5oA:1.7 | 3frqA-1t5oA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tl7 | ADENYLATE CYCLASE,TYPE V (Canis lupus) |
PF00211(Guanylate_cyc) | 4 | ASN A 389ASN A 537HIS A 457ALA A 456 | None | 1.25A | 3frqA-1tl7A:1.5 | 3frqA-1tl7A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzp | ACYLAMINO-ACID-RELEASING ENZYME (Aeropyrumpernix) |
PF00326(Peptidase_S9) | 4 | ASN A 284ASN A 396HIS A 367ALA A 372 | None | 1.47A | 3frqA-2qzpA:0.9 | 3frqA-2qzpA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 4 | ASN A 342ASN A 378HIS A 381ALA A 337 | None | 1.40A | 3frqA-3aqpA:undetectable | 3frqA-3aqpA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ARG A 469ASN A 466HIS A 435ALA A 434 | None | 1.07A | 3frqA-3decA:undetectable | 3frqA-3decA:13.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emk | GLUCOSE/RIBITOLDEHYDROGENASE (Brucellamelitensis) |
PF13561(adh_short_C2) | 4 | ASN A 174ARG A 133ASN A 178ALA A 167 | None | 1.46A | 3frqA-3emkA:undetectable | 3frqA-3emkA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3enk | UDP-GLUCOSE4-EPIMERASE (Burkholderiapseudomallei) |
PF16363(GDP_Man_Dehyd) | 4 | ASN A 334ARG A 47HIS A 19ALA A 186 | None | 1.09A | 3frqA-3enkA:undetectable | 3frqA-3enkA:21.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3frq | REPRESSOR PROTEINMPHR(A) (Escherichiacoli) |
PF00440(TetR_N) | 5 | ASN A 102ARG A 122ASN A 123HIS A 147ALA A 151 | ERY A 195 (-3.9A)ERY A 195 (-3.8A)ERY A 195 ( 3.7A)ERY A 195 (-4.2A)ERY A 195 (-3.3A) | 0.00A | 3frqA-3frqA:32.2 | 3frqA-3frqA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gnq | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE, TYPEI (Burkholderiapseudomallei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 4 | ARG A 14ASN A 15HIS A 53ALA A 52 | None | 1.10A | 3frqA-3gnqA:undetectable | 3frqA-3gnqA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | SMALL NUCLEARRIBONUCLEOPROTEIN SMD3SMALL NUCLEARRIBONUCLEOPROTEIN G (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF01423(LSM)PF01423(LSM) | 4 | ASN J 39ARG D 62ASN D 36ALA J 6 | U C 97 ( 3.1A) U C 97 ( 3.2A) U C 98 ( 4.0A)None | 1.43A | 3frqA-3jb9J:undetectable | 3frqA-3jb9J:17.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7l | ATRAGIN (Naja atra) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | ASN A 293ASN A 240HIS A 249ALA A 251 | None | 1.40A | 3frqA-3k7lA:undetectable | 3frqA-3k7lA:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7n | K-LIKE (Naja atra) |
PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | ASN A 293ASN A 240HIS A 249ALA A 251 | None | 1.39A | 3frqA-3k7nA:undetectable | 3frqA-3k7nA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l91 | ACYL-HOMOSERINELACTONE ACYLASE PVDQSUBUNIT BETA (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | ASN B 539ASN B 218HIS B 239ALA B 679 | None | 1.15A | 3frqA-3l91B:undetectable | 3frqA-3l91B:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l91 | ACYL-HOMOSERINELACTONE ACYLASE PVDQSUBUNIT BETA (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | ASN B 539ASN B 237HIS B 239ALA B 679 | None | 1.30A | 3frqA-3l91B:undetectable | 3frqA-3l91B:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lyl | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Francisellatularensis) |
PF13561(adh_short_C2) | 4 | ASN A 176ARG A 135ASN A 180ALA A 169 | None | 1.46A | 3frqA-3lylA:undetectable | 3frqA-3lylA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m99 | UBIQUITINCARBOXYL-TERMINALHYDROLASE 8 (Saccharomycescerevisiae) |
PF00443(UCH)PF02148(zf-UBP) | 4 | ASN A 110ARG A 28ASN A 25ALA A 115 | None | 1.45A | 3frqA-3m99A:undetectable | 3frqA-3m99A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r9p | ACKA (Mycobacteriumavium) |
PF00871(Acetate_kinase) | 4 | ASN A 323ARG A 355ASN A 347ALA A 326 | None | 1.49A | 3frqA-3r9pA:undetectable | 3frqA-3r9pA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpc | POSSIBLEMETAL-DEPENDENTHYDROLASE (Veillonellaparvula) |
PF12706(Lactamase_B_2) | 4 | ASN A 41ASN A 9HIS A 223ALA A 191 | NoneNone ZN A 302 (-3.5A)None | 1.33A | 3frqA-3rpcA:undetectable | 3frqA-3rpcA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwb | PYRIDOXAL4-DEHYDROGENASE (Mesorhizobiumloti) |
PF13561(adh_short_C2) | 4 | ASN A 176ARG A 135ASN A 180ALA A 169 | None | 1.39A | 3frqA-3rwbA:undetectable | 3frqA-3rwbA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s55 | PUTATIVE SHORT-CHAINDEHYDROGENASE/REDUCTASE (Mycobacteroidesabscessus) |
PF00106(adh_short) | 4 | ASN A 162ASN A 200HIS A 235ALA A 273 | None | 1.13A | 3frqA-3s55A:undetectable | 3frqA-3s55A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sbq | NITROUS-OXIDEREDUCTASE (Pseudomonasstutzeri) |
no annotation | 4 | ASN A 324ASN A 241HIS A 382ALA A 340 | CA A 703 (-3.0A) CL A 704 (-3.7A)CUK A 702 ( 3.3A)None | 1.49A | 3frqA-3sbqA:undetectable | 3frqA-3sbqA:13.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 370ARG A 315ASN A 314HIS A 344 | SO4 A 414 (-4.8A)SO4 A 414 (-3.7A)NoneNone | 1.34A | 3frqA-3sszA:undetectable | 3frqA-3sszA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stp | GALACTONATEDEHYDRATASE,PUTATIVE (Labrenziaaggregata) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASN A 347ARG A 292ASN A 291HIS A 321 | None | 1.31A | 3frqA-3stpA:undetectable | 3frqA-3stpA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttf | TRANSCRIPTIONALREGULATORY PROTEIN (Escherichiacoli) |
PF01300(Sua5_yciO_yrdC)PF07503(zf-HYPF) | 4 | ARG A 702ASN A 701HIS A 669ALA A 626 | NoneAMP A 747 (-3.9A)NoneNone | 1.28A | 3frqA-3ttfA:undetectable | 3frqA-3ttfA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tts | BETA-GALACTOSIDASE (Bacilluscirculans) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 4 | ARG A 106ASN A 113HIS A 85ALA A 90 | None | 1.40A | 3frqA-3ttsA:undetectable | 3frqA-3ttsA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vv3 | DESEASIN MCP-01 (Pseudoalteromonassp. SM9913) |
PF00082(Peptidase_S8) | 4 | ASN A 16ARG A 317ASN A 319ALA A 30 | None | 1.42A | 3frqA-3vv3A:0.5 | 3frqA-3vv3A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuc | GALECTIN (Xenopus laevis) |
PF00337(Gal-bind_lectin) | 4 | ASN A 125ARG A 32ASN A 31ALA A 27 | MLA A 203 (-3.9A)GAL A 202 (-2.8A)NoneNone | 1.28A | 3frqA-3wucA:undetectable | 3frqA-3wucA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a1o | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Mycobacteriumtuberculosis) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 4 | ASN A 394ARG A 419HIS A 520ALA A 518 | None | 1.22A | 3frqA-4a1oA:undetectable | 3frqA-4a1oA:18.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arx | PESTICIDAL CRYSTALPROTEIN CRY1AC (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 4 | ASN A 194ARG A 192ASN A 138HIS A 168 | None | 1.27A | 3frqA-4arxA:undetectable | 3frqA-4arxA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX BETA-CHAINFADA (Mycobacteriumtuberculosis) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASN C 249ARG C 164ASN C 256ALA C 153 | SO4 C1405 (-3.5A)NoneNoneNone | 1.41A | 3frqA-4b3iC:undetectable | 3frqA-4b3iC:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cyf | PANTETHEINASE (Homo sapiens) |
PF00795(CN_hydrolase) | 4 | ARG A 55ASN A 56HIS A 32ALA A 33 | NAG A 603 (-3.6A)NoneNoneNone | 1.23A | 3frqA-4cyfA:0.2 | 3frqA-4cyfA:17.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3d | IMINE REDUCTASE (Bacillus cereus) |
PF03446(NAD_binding_2) | 4 | ASN A 90ASN A 110HIS A 133ALA A 122 | None | 1.27A | 3frqA-4d3dA:undetectable | 3frqA-4d3dA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fye | SIDF, INHIBITOR OFGROWTH FAMILY,MEMBER 3 (Legionellapneumophila) |
no annotation | 4 | ASN A 242ASN A 710HIS A 706ALA A 246 | None | 0.94A | 3frqA-4fyeA:0.0 | 3frqA-4fyeA:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0w | U3 SMALL NUCLEOLARRNA-INTERACTINGPROTEIN 2 (Homo sapiens) |
PF00400(WD40) | 4 | ASN A 387ARG A 251HIS A 331ALA A 384 | None | 1.21A | 3frqA-4j0wA:undetectable | 3frqA-4j0wA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k90 | EXTRACELLULARMETALLOPROTEINASEMEP (Aspergillusfumigatus) |
PF02128(Peptidase_M36) | 4 | ASN A 370ASN A 294HIS A 350ALA A 274 | None | 1.36A | 3frqA-4k90A:undetectable | 3frqA-4k90A:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mae | METHANOLDEHYDROGENASE (Methylacidiphilumfumariolicum) |
PF13360(PQQ_2) | 4 | ASN A 256ARG A 326ASN A 304HIS A 323 | CE A 601 ( 3.4A)PQQ A 602 (-2.7A)NoneNone | 1.49A | 3frqA-4maeA:undetectable | 3frqA-4maeA:15.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oet | PUTATIVE PEPTIDEABC-TRANSPORT SYSTEMPERIPLASMICPEPTIDE-BINDINGPROTEIN (Campylobacterjejuni) |
PF00496(SBP_bac_5) | 4 | ASN A 97ARG A 17ASN A 19ALA A 90 | None | 1.06A | 3frqA-4oetA:undetectable | 3frqA-4oetA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4osp | OXYGENASE-REDUCTASE (Streptomycesfradiae) |
PF13561(adh_short_C2) | 4 | ASN A 182ARG A 141ASN A 186ALA A 175 | None | 1.40A | 3frqA-4ospA:undetectable | 3frqA-4ospA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wpz | CYTOCHROME P450 (Streptomycesavermitilis) |
PF00067(p450) | 4 | ASN A 143ASN A 172HIS A 241ALA A 245 | None | 1.41A | 3frqA-4wpzA:1.0 | 3frqA-4wpzA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydi | ENVELOPEGLYCOPROTEIN GP160HEAVY CHAIN OFANTIBODYZ258-VRC27.01 (Humanimmunodeficiencyvirus 1;Homo sapiens) |
PF00516(GP120)PF07654(C1-set)PF07686(V-set) | 4 | ASN G 462ARG G 456ASN G 280ALA H 60 | NAG G 512 (-4.5A)NoneNoneNone | 1.23A | 3frqA-4ydiG:undetectable | 3frqA-4ydiG:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cww | NUCLEOPORIN NUP82 (Chaetomiumthermophilum) |
no annotation | 4 | ASN B 125ARG B 262HIS B 181ALA B 189 | None | 1.32A | 3frqA-5cwwB:undetectable | 3frqA-5cwwB:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmq | INFLUENZA A PB2SUBUNIT (Influenza Avirus) |
PF00604(Flu_PB2) | 4 | ASN A 510ARG A 355ASN A 429HIS A 432 | MGT A1676 (-3.5A)MGT A1676 (-3.4A)MGT A1676 (-3.6A)None | 1.38A | 3frqA-5fmqA:1.0 | 3frqA-5fmqA:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxv | HISTONE DEMETHYLASEUTY (Homo sapiens) |
PF02373(JmjC) | 4 | ASN A1287ARG A1226ASN A1223ALA A1275 | None | 1.47A | 3frqA-5fxvA:undetectable | 3frqA-5fxvA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m59 | PRE-MRNA SPLICINGHELICASE-LIKEPROTEINPUTATIVE PRE-MRNASPLICING FACTOR (Chaetomiumthermophilum;Chaetomiumthermophilum) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63)PF08084(PROCT) | 4 | ASN B2055ARG B2057ASN A1059ALA B2050 | None | 1.18A | 3frqA-5m59B:0.1 | 3frqA-5m59B:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN326S PROTEASOMEREGULATORY SUBUNITRPN12 (Saccharomycescerevisiae;Saccharomycescerevisiae) |
PF01399(PCI)PF08375(Rpn3_C)PF10075(CSN8_PSD8_EIF3K) | 4 | ASN T 93ASN S 207HIS S 191ALA S 195 | None | 1.30A | 3frqA-5mpdT:undetectable | 3frqA-5mpdT:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT AMETHYL-VIOLOGENREDUCINGHYDROGENASE, SUBUNITD (Methanothermococcusthermolithotrophicus;Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9)PF02662(FlpD) | 4 | ARG A 100ASN A 98HIS A 102ALA D 21 | SF4 A 705 (-4.1A)NoneNoneNone | 1.26A | 3frqA-5odrA:undetectable | 3frqA-5odrA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | ASN A 323ASN A 2HIS A 23ALA A 463 | None | 1.14A | 3frqA-5ubkA:undetectable | 3frqA-5ubkA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 4 | ASN A 323ASN A 21HIS A 23ALA A 463 | None | 1.29A | 3frqA-5ubkA:undetectable | 3frqA-5ubkA:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uke | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 3 (Homo sapiens) |
no annotation | 4 | ASN A 9ARG A 75HIS A 19ALA A 12 | None | 0.99A | 3frqA-5ukeA:undetectable | 3frqA-5ukeA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 4 | ASN A 633ARG A 629ASN A 277ALA A 678 | None | 1.50A | 3frqA-5wugA:undetectable | 3frqA-5wugA:undetectable |