SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRQ_A_ERYA195

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		5 THR A  80
LEU A  10
VAL A 127
ILE A 153
THR A  19
 None
 1.32A 3frqA-1a6jA:
0.0		 3frqA-1a6jA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 THR A 336
LEU A 443
TYR A 293
VAL A 412
ILE A 390
 None
 1.21A 3frqA-1bdgA:
0.0		 3frqA-1bdgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		5 VAL A  53
LEU A  74
SER A 159
VAL A  28
ILE A 236
 None
 1.38A 3frqA-1ce7A:
undetectable		 3frqA-1ce7A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1u PROTEIN (REVERSE
TRANSCRIPTASE)

(Murine leukemia
virus) 		PF00078
(RVT_1) 		5 THR A  96
LEU A 198
SER A 195
SER A  56
ILE A 125
 None
 1.29A 3frqA-1d1uA:
undetectable		 3frqA-1d1uA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE

(Aspergillus
aculeatus) 		PF13472
(Lipase_GDSL_2) 		5 LEU A  27
MET A  11
TYR A  48
VAL A  35
ILE A  68
 None
 1.35A 3frqA-1dexA:
0.0		 3frqA-1dexA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE

(Lactobacillus
pentosus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 TYR A  35
LEU A 134
SER A 259
SER A 167
ILE A 159
 None
 1.30A 3frqA-1ez4A:
0.0		 3frqA-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv CYTOCHROME C1

(Saccharomyces
cerevisiae) 		PF02167
(Cytochrom_C1) 		5 VAL D  96
TYR D  97
LEU D 255
TYR D 198
ILE D 191
 None
None
None
None
HEM  D   3 (-4.4A)
 1.21A 3frqA-1ezvD:
undetectable		 3frqA-1ezvD:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 VAL A 294
LEU A 186
VAL A 296
ILE A 172
THR A 159
 None
 1.27A 3frqA-1flgA:
undetectable		 3frqA-1flgA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 THR A 113
TYR A 513
LEU A 498
TYR A 187
ILE A 526
 None
 1.30A 3frqA-1gz4A:
0.0		 3frqA-1gz4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 THR A 673
LEU A  24
SER A  27
MET A  28
ILE A   4
 None
 1.37A 3frqA-1h54A:
0.2		 3frqA-1h54A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 THR A  32
VAL A 316
LEU A 370
SER A 361
VAL A 333
 None
 1.35A 3frqA-1hkwA:
0.0		 3frqA-1hkwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 316
TYR A 314
LEU A 370
SER A 361
VAL A 333
 None
 1.17A 3frqA-1hkwA:
0.0		 3frqA-1hkwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i36 CONSERVED
HYPOTHETICAL PROTEIN
MTH1747

(Methanothermobacter
thermautotrophicus) 		PF03807
(F420_oxidored)
PF09130
(DUF1932) 		5 VAL A 116
LEU A  15
SER A 156
VAL A  11
ILE A  61
 NAP  A1350 (-3.9A)
None
None
NAP  A1350 (-3.8A)
None
 1.21A 3frqA-1i36A:
2.2		 3frqA-1i36A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		5 LEU A 307
SER A  64
VAL A 309
ILE A 295
THR A 344
 None
 1.38A 3frqA-1k7hA:
undetectable		 3frqA-1k7hA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mec MENGO VIRUS COAT
PROTEIN (SUBUNIT
VP1)

(Cardiovirus A) 		no annotation 5 THR 1 150
VAL 1 188
LEU 1 240
VAL 1 129
ILE 1  43
 None
 1.28A 3frqA-1mec1:
undetectable		 3frqA-1mec1:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3g ADENYLATE KINASE

(Sporosarcina
globispora) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 THR A  89
VAL A  63
MET A  53
SER A  30
ILE A  39
 None
None
AP5  A 218 (-4.2A)
AP5  A 218 ( 4.7A)
None
 1.37A 3frqA-1s3gA:
undetectable		 3frqA-1s3gA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 VAL A 309
TYR A 306
LEU A 257
TYR A 331
ILE A 255
 None
 1.36A 3frqA-1s5jA:
undetectable		 3frqA-1s5jA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3h T-CELL RECEPTOR
ALPHA-CHAIN

(Mus musculus) 		PF07686
(V-set) 		5 THR A 102
VAL A   3
TYR A  24
LEU A  73
ILE A  64
 None
 1.28A 3frqA-1u3hA:
undetectable		 3frqA-1u3hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmi PUTATIVE PHOSPHATE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF01515
(PTA_PTB) 		5 TYR A 286
LEU A 154
VAL A 289
ILE A   2
THR A 193
 None
 1.23A 3frqA-1vmiA:
undetectable		 3frqA-1vmiA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL A 223
LEU A  56
SER A 147
VAL A 219
ILE A  53
 None
 1.32A 3frqA-1w5eA:
undetectable		 3frqA-1w5eA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf3 GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF07650
(KH_2) 		5 VAL A 236
LEU A 205
VAL A 245
ILE A 256
THR A 260
 None
 1.12A 3frqA-1wf3A:
undetectable		 3frqA-1wf3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhc NADH OXIDASE
/NITRITE REDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2) 		5 VAL A  85
LEU A 230
SER A 234
VAL A   6
THR A 250
 None
FAD  A 360 ( 4.3A)
None
None
None
 1.25A 3frqA-1xhcA:
undetectable		 3frqA-1xhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yga HYPOTHETICAL 37.9
KDA PROTEIN IN
BIO3-HXT17
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		5 THR A 193
VAL A  42
LEU A  32
SER A 177
THR A 336
 None
 0.96A 3frqA-1ygaA:
undetectable		 3frqA-1ygaA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		5 LEU A  45
SER A  42
VAL A 252
ILE A 291
THR A 289
 None
 1.27A 3frqA-1yifA:
undetectable		 3frqA-1yifA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		5 VAL A  86
LEU A 148
SER A 241
VAL A  66
ILE A 232
 None
 1.05A 3frqA-1yw4A:
undetectable		 3frqA-1yw4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 VAL A 497
LEU A 550
SER A 566
VAL A 481
ILE A 471
 None
 1.38A 3frqA-2bf6A:
undetectable		 3frqA-2bf6A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7v HYPOTHETICAL PROTEIN
VCA0330

(Vibrio cholerae) 		PF02566
(OsmC) 		5 VAL A  92
TYR A  90
LEU A 135
VAL A 122
ILE A 160
 None
 1.09A 3frqA-2d7vA:
undetectable		 3frqA-2d7vA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		5 VAL A 271
LEU A 233
SER A  22
VAL A 250
THR A 261
 None
 1.18A 3frqA-2gsjA:
undetectable		 3frqA-2gsjA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyp HYPOTHETICAL PROTEIN
RV0805

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		5 VAL A  94
LEU A 204
VAL A  59
ILE A 165
THR A 164
 None
 1.35A 3frqA-2hypA:
undetectable		 3frqA-2hypA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j22 FUCOLECTIN-RELATED
PROTEIN

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		5 VAL A  37
LEU A 140
TYR A  95
VAL A 143
ILE A 129
 None
 1.25A 3frqA-2j22A:
undetectable		 3frqA-2j22A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lyi PROTEIN (ENTITY)

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 THR A  21
LEU A  92
SER A  88
VAL A 106
ILE A  52
 None
 1.31A 3frqA-2lyiA:
undetectable		 3frqA-2lyiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nly DIVERGENT
POLYSACCHARIDE
DEACETYLASE
HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF04748
(Polysacc_deac_2) 		5 VAL A 152
MET A 145
SER A 162
VAL A 117
ILE A 104
 None
 1.26A 3frqA-2nlyA:
undetectable		 3frqA-2nlyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2put ISOMERASE DOMAIN OF
GLUTAMINE-FRUCTOSE-6
-PHOSPHATE
TRANSAMINASE
(ISOMERIZING)

(Candida
albicans) 		PF01380
(SIS) 		5 THR A 421
VAL A 447
VAL A 449
ILE A 493
THR A 368
 None
 1.38A 3frqA-2putA:
undetectable		 3frqA-2putA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 THR A 301
LEU A 670
VAL A 682
ILE A 666
THR A 697
 None
 1.30A 3frqA-2vwkA:
undetectable		 3frqA-2vwkA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn9 POTASSIUM-TRANSPORTI
NG ATPASE ALPHA
CHAIN 1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF09040
(H-K_ATPase_N)
PF13246
(Cation_ATPase) 		5 VAL A 222
LEU A 227
SER A 226
ILE A 275
THR A 274
 None
 1.35A 3frqA-2yn9A:
1.2		 3frqA-2yn9A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		5 VAL A 316
LEU A  68
SER A  37
VAL A 314
ILE A 301
 None
 0.98A 3frqA-3abbA:
undetectable		 3frqA-3abbA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 THR A 338
TYR A 194
LEU A 203
ILE A 206
THR A 170
 None
 1.32A 3frqA-3aqiA:
undetectable		 3frqA-3aqiA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		5 THR A 318
LEU A 625
TYR A 372
VAL A 630
ILE A 456
 None
 1.08A 3frqA-3biwA:
undetectable		 3frqA-3biwA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4o DIPICOLINATE
SYNTHASE SUBUNIT A

(Bacillus
halodurans) 		PF01262
(AlaDh_PNT_C)
PF16924
(DpaA_N) 		5 VAL A  58
MET A  89
TYR A 107
VAL A   8
ILE A  50
 None
 1.25A 3frqA-3d4oA:
undetectable		 3frqA-3d4oA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 THR A1067
LEU A1119
SER A1186
VAL A1117
ILE A1135
 None
 1.26A 3frqA-3egwA:
0.6		 3frqA-3egwA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		5 VAL A  47
SER A 224
SER A 236
VAL A  49
ILE A  69
 None
 1.26A 3frqA-3fj7A:
undetectable		 3frqA-3fj7A:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		11 THR A  17
LYS A  21
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
CL  A 198 ( 4.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.02A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		11 THR A  17
VAL A  66
TYR A  69
LEU A  89
SER A  92
MET A  93
TYR A 103
SER A 106
VAL A 126
ILE A 150
THR A 154
 ERY  A 195 (-4.4A)
ERY  A 195 (-4.2A)
ERY  A 195 (-4.0A)
ERY  A 195 (-4.6A)
ERY  A 195 (-3.6A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-3.9A)
ERY  A 195 (-2.9A)
ERY  A 195 ( 4.6A)
ERY  A 195 ( 4.2A)
ERY  A 195 ( 4.1A)
 0.44A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA
CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF03063
(Prismane)
PF03598
(CdhC) 		5 THR A 593
VAL A 228
TYR A 674
SER A 625
ILE M 113
 None
 1.36A 3frqA-3i04A:
undetectable		 3frqA-3i04A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		5 TYR A 158
LEU A 103
SER A 167
ILE A 112
THR A 116
 None
NAE  A 311 (-3.9A)
None
None
None
 1.30A 3frqA-3i3oA:
undetectable		 3frqA-3i3oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 THR A 133
VAL A 198
LEU A  96
SER A 140
ILE A 146
 None
 1.39A 3frqA-3i6uA:
undetectable		 3frqA-3i6uA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib7 ICC PROTEIN

(Mycobacterium
tuberculosis) 		PF00149
(Metallophos) 		5 VAL A  94
LEU A 204
VAL A  59
ILE A 165
THR A 164
 None
 1.37A 3frqA-3ib7A:
undetectable		 3frqA-3ib7A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixc HEXAPEPTIDE
TRANSFERASE FAMILY
PROTEIN

(Anaplasma
phagocytophilum) 		PF00132
(Hexapep) 		5 LEU A   5
SER A 166
VAL A  15
ILE A  27
THR A  43
 None
 1.38A 3frqA-3ixcA:
undetectable		 3frqA-3ixcA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 THR A 170
VAL A  84
LEU A   8
ILE A  19
THR A 145
 None
 1.13A 3frqA-3k53A:
undetectable		 3frqA-3k53A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keq REDOX-SENSING
TRANSCRIPTIONAL
REPRESSOR REX

(Streptococcus
agalactiae) 		PF02629
(CoA_binding)
PF06971
(Put_DNA-bind_N) 		5 VAL A 156
LEU A 168
SER A 120
VAL A  90
ILE A 140
 NAD  A 213 (-4.0A)
None
None
None
None
 1.37A 3frqA-3keqA:
3.6		 3frqA-3keqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 THR A 393
SER A 357
MET A 386
ILE A 234
THR A 408
 None
 1.06A 3frqA-3nd0A:
undetectable		 3frqA-3nd0A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 VAL A 270
LEU A 294
SER A  18
VAL A 257
ILE A 286
 None
None
None
FAD  A 479 (-3.7A)
FAD  A 479 (-3.9A)
 1.12A 3frqA-3nksA:
undetectable		 3frqA-3nksA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oka GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-6)-PHOSPHAT
IDYLINOSITOL
MONOMANNOSIDE
MANNOSYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 THR A 164
LEU A  25
VAL A   9
ILE A  29
THR A  31
 None
 1.39A 3frqA-3okaA:
undetectable		 3frqA-3okaA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		5 VAL A1234
LEU A1286
VAL A1231
ILE A1284
THR A1282
 None
 1.38A 3frqA-3opuA:
undetectable		 3frqA-3opuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 LYS B 899
LEU B 483
SER B 712
VAL B 928
ILE B 479
 None
 1.26A 3frqA-3opyB:
undetectable		 3frqA-3opyB:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 LYS A 312
VAL A 118
LEU A 110
SER A 139
THR A 155
 None
 1.32A 3frqA-3oqnA:
undetectable		 3frqA-3oqnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 THR B 789
LEU B 979
SER B 860
SER B 918
ILE B1039
 None
 1.26A 3frqA-3p8cB:
undetectable		 3frqA-3p8cB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 THR A 268
VAL A 229
SER A 302
VAL A 142
THR A 165
 None
 1.34A 3frqA-3q8nA:
undetectable		 3frqA-3q8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 THR A 268
VAL A 262
SER A 302
VAL A 142
THR A 165
 None
 1.28A 3frqA-3q8nA:
undetectable		 3frqA-3q8nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		5 TYR A 247
LEU A 262
SER A 265
VAL A 194
ILE A 308
 None
 1.20A 3frqA-3q9cA:
undetectable		 3frqA-3q9cA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmv GLYCOGENIN-1

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 THR A  32
VAL A  99
LEU A 183
SER A  25
VAL A 136
 None
 1.35A 3frqA-3rmvA:
undetectable		 3frqA-3rmvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		5 THR A 313
VAL A 116
SER A 241
VAL A  73
THR A  27
 None
 1.22A 3frqA-3slgA:
undetectable		 3frqA-3slgA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vup BETA-1,4-MANNANASE

(Aplysia kurodai) 		PF00150
(Cellulase) 		5 VAL A 148
LEU A  95
MET A  88
ILE A  63
THR A  70
 None
 1.36A 3frqA-3vupA:
undetectable		 3frqA-3vupA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9r ABSCISIC ACID
RECEPTOR PYL9

(Arabidopsis
thaliana) 		PF10604
(Polyketide_cyc2) 		5 THR A  17
VAL A 128
LEU A 173
TYR A 122
VAL A  53
 None
None
None
A8S  A 201 (-4.4A)
None
 1.29A 3frqA-3w9rA:
undetectable		 3frqA-3w9rA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a27 SYNAPTIC VESICLE
MEMBRANE PROTEIN
VAT-1 HOMOLOG-LIKE

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 TYR A 169
LEU A 172
VAL A 197
ILE A 249
THR A 271
 None
None
None
None
EDO  A1387 (-3.9A)
 1.23A 3frqA-4a27A:
undetectable		 3frqA-4a27A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 VAL A 352
LEU A 358
SER A 344
VAL A 320
ILE A 296
 None
 1.26A 3frqA-4a9aA:
undetectable		 3frqA-4a9aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3h DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA190

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 TYR A 801
LEU A 736
SER A 789
VAL A 809
ILE A 732
 None
 1.23A 3frqA-4c3hA:
undetectable		 3frqA-4c3hA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ej0 ADP-L-GLYCERO-D-MANN
O-HEPTOSE-6-EPIMERAS
E

(Burkholderia
thailandensis) 		PF01370
(Epimerase) 		5 THR A 242
VAL A 319
TYR A 322
SER A 182
VAL A 255
 None
 1.11A 3frqA-4ej0A:
undetectable		 3frqA-4ej0A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8x ENDO-1,4-BETA-XYLANA
SE

(Penicillium
canescens) 		PF00331
(Glyco_hydro_10) 		5 VAL A 117
LEU A 131
MET A 135
VAL A 170
ILE A 175
 None
 1.17A 3frqA-4f8xA:
undetectable		 3frqA-4f8xA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go6 HCF C-TERMINAL CHAIN
1

(Homo sapiens) 		no annotation 5 VAL B1815
TYR B1828
LEU B1856
SER B1878
VAL B1825
 None
 1.36A 3frqA-4go6B:
undetectable		 3frqA-4go6B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqc PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Brachyspira
murdochii) 		PF13407
(Peripla_BP_4) 		5 THR A 319
TYR A 339
LEU A 278
SER A 273
ILE A 329
 None
 1.27A 3frqA-4kqcA:
0.8		 3frqA-4kqcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN

(Ketogulonicigenium
vulgare) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 100
SER A 284
SER A 236
VAL A  76
ILE A 156
 None
 1.19A 3frqA-4lswA:
undetectable		 3frqA-4lswA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbo SERINE-RICH REPEAT
ADHESION
GLYCOPROTEIN (SRR1)

(Streptococcus
agalactiae) 		PF10425
(SdrG_C_C) 		5 VAL A 597
TYR A 498
SER A 608
SER A 570
ILE A 502
 None
 1.37A 3frqA-4mboA:
undetectable		 3frqA-4mboA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdy PERIPLASMIC BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01497
(Peripla_BP_2) 		5 VAL A 187
LEU A 312
SER A 300
ILE A 253
THR A 285
 None
 1.15A 3frqA-4mdyA:
undetectable		 3frqA-4mdyA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 LEU A 541
SER A 545
SER A 460
VAL A 518
ILE A 445
 None
 1.29A 3frqA-4mzdA:
undetectable		 3frqA-4mzdA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 VAL A 205
LEU A 173
TYR A 310
VAL A 185
ILE A 150
 None
 1.10A 3frqA-4nurA:
0.0		 3frqA-4nurA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2t UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF16109
(DUF4827) 		5 THR A  88
VAL A 151
TYR A 150
LEU A  72
VAL A 157
 None
 1.15A 3frqA-4o2tA:
undetectable		 3frqA-4o2tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		5 VAL A  50
LEU A 107
VAL A  42
ILE A 130
THR A 148
 None
 1.37A 3frqA-4oecA:
undetectable		 3frqA-4oecA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 THR A 441
VAL A 339
LEU A 331
SER A 379
THR A 351
 None
 1.18A 3frqA-4oj5A:
undetectable		 3frqA-4oj5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 THR A  52
VAL A  41
TYR A  99
VAL A  38
THR A 141
 GOL  A 204 ( 4.7A)
None
None
None
GA3  A 201 (-2.8A)
 1.31A 3frqA-4q0kA:
undetectable		 3frqA-4q0kA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  32
LEU A  20
VAL A  46
ILE A  15
THR A  87
 None
 1.18A 3frqA-4redA:
undetectable		 3frqA-4redA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u49 PECTATE LYASE

(Pectobacterium
carotovorum) 		PF03211
(Pectate_lyase) 		5 THR A  24
VAL A  51
TYR A  88
SER A  71
THR A 275
 None
 1.32A 3frqA-4u49A:
undetectable		 3frqA-4u49A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueg GLYCOGENIN-2

(Homo sapiens) 		PF01501
(Glyco_transf_8) 		5 THR A  34
VAL A 101
LEU A 185
SER A  27
VAL A 138
 None
 1.36A 3frqA-4uegA:
undetectable		 3frqA-4uegA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8s GUANINE-N7
METHYLTRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06471
(NSP11) 		5 VAL B 236
LEU B 174
MET B 169
VAL B 181
THR B 113
 None
 1.12A 3frqA-5c8sB:
undetectable		 3frqA-5c8sB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d2e MLNE

(Bacillus
velezensis) 		PF08659
(KR) 		5 TYR A 188
LEU A 148
SER A 151
SER A 410
ILE A 381
 None
 1.37A 3frqA-5d2eA:
undetectable		 3frqA-5d2eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6a PREDICTED ATPASE OF
THE ABC CLASS

(Vibrio
vulnificus) 		PF09818
(ABC_ATPase) 		5 THR A 218
LEU A 250
SER A 214
ILE A 239
THR A 237
 None
 1.24A 3frqA-5d6aA:
undetectable		 3frqA-5d6aA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 THR A 197
LEU A  24
TYR A 209
ILE A  37
THR A  40
 None
 1.14A 3frqA-5dtrA:
undetectable		 3frqA-5dtrA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 THR A 586
VAL A 116
VAL A 114
ILE A  49
THR A  52
 None
 1.15A 3frqA-5fp1A:
undetectable		 3frqA-5fp1A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5h INNER MEMBRANE
PROTEIN YEJM

(Escherichia
coli) 		PF00884
(Sulfatase)
PF11893
(DUF3413) 		5 LEU A 263
SER A 395
SER A 371
VAL A 430
ILE A 265
 None
 1.17A 3frqA-5i5hA:
undetectable		 3frqA-5i5hA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iww MULTIPLE ORGANELLAR
RNA EDITING FACTOR
9, CHLOROPLASTIC
PLS9-PPR

(Arabidopsis
thaliana;
unidentified) 		no annotation
PF12854
(PPR_1)
PF13041
(PPR_2) 		5 VAL A 169
LEU A  82
SER A 165
VAL D 145
ILE D 175
 None
 1.32A 3frqA-5iwwA:
undetectable		 3frqA-5iwwA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jho ELECTRONEUTRAL
SODIUM BICARBONATE
EXCHANGER 1

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 THR A  83
LEU A 113
SER A 112
SER A 248
ILE A 333
 None
 1.25A 3frqA-5jhoA:
undetectable		 3frqA-5jhoA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 THR A 231
TYR A 238
LEU A 288
SER A 180
ILE A   8
 None
 1.39A 3frqA-5mg5A:
undetectable		 3frqA-5mg5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 VAL A  96
LEU A 251
SER A  17
VAL A  83
ILE A 113
 None
FAD  A 401 ( 3.9A)
None
FAD  A 401 (-3.9A)
FAD  A 401 (-3.6A)
 1.08A 3frqA-5twbA:
undetectable		 3frqA-5twbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz8 GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 VAL A   5
LEU A  19
SER A  22
VAL A   7
ILE A  16
 None
 1.29A 3frqA-5tz8A:
undetectable		 3frqA-5tz8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzk GLYCOSYL TRANSFERASE

(Staphylococcus
aureus) 		PF00535
(Glycos_transf_2) 		5 VAL C   5
LEU C  19
SER C  22
VAL C   7
ILE C  16
 None
 1.30A 3frqA-5tzkC:
undetectable		 3frqA-5tzkC:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		no annotation 5 THR A  70
VAL A 240
LEU A 272
SER A 117
VAL A 228
 None
 1.10A 3frqA-5v4pA:
1.2		 3frqA-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viu ACETYLORNITHINE
AMINOTRANSFERASE

(Elizabethkingia
anophelis) 		PF00202
(Aminotran_3) 		5 THR A 241
LYS A 345
VAL A 252
TYR A 208
ILE A 179
 None
None
None
None
EDO  A 506 (-4.8A)
 1.24A 3frqA-5viuA:
undetectable		 3frqA-5viuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6n HELICASE DOMAIN FROM
GENOME POLYPROTEIN

(Zika virus) 		no annotation 5 THR A 201
VAL A 227
LEU A 386
SER A 412
ILE A 384
 MN  A 701 ( 3.2A)
None
None
None
None
 1.38A 3frqA-5y6nA:
undetectable		 3frqA-5y6nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Acinetobacter
baumannii) 		no annotation 5 THR A 434
LEU A 452
SER A 451
VAL A 413
ILE A 427
 None
 1.25A 3frqA-6d6kA:
undetectable		 3frqA-6d6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 THR K 131
LEU K  73
VAL K  98
ILE K 109
THR K 113
 None
 1.37A 3frqA-6d6qK:
undetectable		 3frqA-6d6qK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 ASN A  71
ASN A  41
HIS A 102
ALA A  66
 None
 1.14A 3frqA-1bqbA:
0.0		 3frqA-1bqbA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1btn BETA-SPECTRIN

(Mus musculus) 		PF15410
(PH_9) 		4 ASN A  15
ASN A  84
HIS A   9
ALA A  18
 None
 0.98A 3frqA-1btnA:
undetectable		 3frqA-1btnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 ASN P 222
ASN P 141
HIS P 194
ALA P 210
 None
SO4  P1001 (-3.5A)
SO4  P1001 (-4.1A)
None
 1.40A 3frqA-1cf2P:
0.0		 3frqA-1cf2P:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.30A 3frqA-1ciyA:
1.1		 3frqA-1ciyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		4 ASN A 212
ASN A 201
HIS A 244
ALA A 209
 None
 1.26A 3frqA-1cjaA:
0.1		 3frqA-1cjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 169
ARG A 171
ASN A 180
ALA A 163
 None
 1.26A 3frqA-1db3A:
undetectable		 3frqA-1db3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri;
Methanopyrus
kandleri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN A 477
ARG B 384
ASN B 379
ALA A 272
 None
 1.27A 3frqA-1e6vA:
0.5		 3frqA-1e6vA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA
METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri;
Methanosarcina
barkeri) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ASN A1494
ARG B2381
ASN B2376
ALA A1283
 AGM  A1285 ( 3.7A)
None
None
None
 1.13A 3frqA-1e6yA:
0.5		 3frqA-1e6yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 534
ARG A 464
ASN A 441
ALA A 468
 None
 1.48A 3frqA-1fepA:
undetectable		 3frqA-1fepA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE

(Paracoccus
denitrificans) 		PF13473
(Cupredoxin_1) 		4 ASN A 268
ASN A 189
HIS A 325
ALA A 284
 CA  A4903 (-3.0A)
CL  A4901 (-3.8A)
CUZ  A4801 ( 3.3A)
None
 1.44A 3frqA-1fwxA:
0.0		 3frqA-1fwxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ASN A 319
ARG A 102
HIS A  10
ALA A 355
 None
 1.21A 3frqA-1kwgA:
undetectable		 3frqA-1kwgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 198
ARG A 200
ASN A 209
ALA A 192
 None
 1.23A 3frqA-1n7gA:
undetectable		 3frqA-1n7gA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		4 ASN A 275
ASN A 374
HIS A 377
ALA A 328
 NAI  A 920 (-3.1A)
None
None
NAI  A 920 (-3.9A)
 1.45A 3frqA-1o0sA:
undetectable		 3frqA-1o0sA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obf GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Achromobacter
xylosoxidans) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG O  14
ASN O  15
HIS O  53
ALA O  52
 None
 1.13A 3frqA-1obfO:
undetectable		 3frqA-1obfO:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ow0 IG ALPHA-1 CHAIN C
REGION

(Homo sapiens) 		PF00047
(ig)
PF07654
(C1-set) 		4 ASN A 316
ARG A 250
HIS A 436
ALA A 438
 None
 1.43A 3frqA-1ow0A:
undetectable		 3frqA-1ow0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdu CASPASE-8
ALPHA-CHAIN

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 ASN A 180
ARG A 179
ASN A 169
HIS A 204
 None
 1.22A 3frqA-1qduA:
undetectable		 3frqA-1qduA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5o TRANSLATION
INITIATION FACTOR
EIF2B, SUBUNIT DELTA

(Archaeoglobus
fulgidus) 		PF01008
(IF-2B) 		4 ASN A  93
ARG A 132
ASN A 133
ALA A 160
 None
 1.16A 3frqA-1t5oA:
1.7		 3frqA-1t5oA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tl7 ADENYLATE CYCLASE,
TYPE V

(Canis lupus) 		PF00211
(Guanylate_cyc) 		4 ASN A 389
ASN A 537
HIS A 457
ALA A 456
 None
 1.25A 3frqA-1tl7A:
1.5		 3frqA-1tl7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 ASN A 284
ASN A 396
HIS A 367
ALA A 372
 None
 1.47A 3frqA-2qzpA:
0.9		 3frqA-2qzpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 ASN A 342
ASN A 378
HIS A 381
ALA A 337
 None
 1.40A 3frqA-3aqpA:
undetectable		 3frqA-3aqpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 ARG A 469
ASN A 466
HIS A 435
ALA A 434
 None
 1.07A 3frqA-3decA:
undetectable		 3frqA-3decA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 ASN A 174
ARG A 133
ASN A 178
ALA A 167
 None
 1.46A 3frqA-3emkA:
undetectable		 3frqA-3emkA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 334
ARG A  47
HIS A  19
ALA A 186
 None
 1.09A 3frqA-3enkA:
undetectable		 3frqA-3enkA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3frq REPRESSOR PROTEIN
MPHR(A)

(Escherichia
coli) 		PF00440
(TetR_N) 		5 ASN A 102
ARG A 122
ASN A 123
HIS A 147
ALA A 151
 ERY  A 195 (-3.9A)
ERY  A 195 (-3.8A)
ERY  A 195 ( 3.7A)
ERY  A 195 (-4.2A)
ERY  A 195 (-3.3A)
 0.00A 3frqA-3frqA:
32.2		 3frqA-3frqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ARG A  14
ASN A  15
HIS A  53
ALA A  52
 None
 1.10A 3frqA-3gnqA:
undetectable		 3frqA-3gnqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D3
SMALL NUCLEAR
RIBONUCLEOPROTEIN G

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF01423
(LSM) 		4 ASN J  39
ARG D  62
ASN D  36
ALA J   6
 U  C  97 ( 3.1A)
U  C  97 ( 3.2A)
U  C  98 ( 4.0A)
None
 1.43A 3frqA-3jb9J:
undetectable		 3frqA-3jb9J:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
 None
 1.40A 3frqA-3k7lA:
undetectable		 3frqA-3k7lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASN A 293
ASN A 240
HIS A 249
ALA A 251
 None
 1.39A 3frqA-3k7nA:
undetectable		 3frqA-3k7nA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASN B 539
ASN B 218
HIS B 239
ALA B 679
 None
 1.15A 3frqA-3l91B:
undetectable		 3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASN B 539
ASN B 237
HIS B 239
ALA B 679
 None
 1.30A 3frqA-3l91B:
undetectable		 3frqA-3l91B:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyl 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 ASN A 176
ARG A 135
ASN A 180
ALA A 169
 None
 1.46A 3frqA-3lylA:
undetectable		 3frqA-3lylA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m99 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Saccharomyces
cerevisiae) 		PF00443
(UCH)
PF02148
(zf-UBP) 		4 ASN A 110
ARG A  28
ASN A  25
ALA A 115
 None
 1.45A 3frqA-3m99A:
undetectable		 3frqA-3m99A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9p ACKA

(Mycobacterium
avium) 		PF00871
(Acetate_kinase) 		4 ASN A 323
ARG A 355
ASN A 347
ALA A 326
 None
 1.49A 3frqA-3r9pA:
undetectable		 3frqA-3r9pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 ASN A  41
ASN A   9
HIS A 223
ALA A 191
 None
None
ZN  A 302 (-3.5A)
None
 1.33A 3frqA-3rpcA:
undetectable		 3frqA-3rpcA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwb PYRIDOXAL
4-DEHYDROGENASE

(Mesorhizobium
loti) 		PF13561
(adh_short_C2) 		4 ASN A 176
ARG A 135
ASN A 180
ALA A 169
 None
 1.39A 3frqA-3rwbA:
undetectable		 3frqA-3rwbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Mycobacteroides
abscessus) 		PF00106
(adh_short) 		4 ASN A 162
ASN A 200
HIS A 235
ALA A 273
 None
 1.13A 3frqA-3s55A:
undetectable		 3frqA-3s55A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 ASN A 324
ASN A 241
HIS A 382
ALA A 340
 CA  A 703 (-3.0A)
CL  A 704 (-3.7A)
CUK  A 702 ( 3.3A)
None
 1.49A 3frqA-3sbqA:
undetectable		 3frqA-3sbqA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 370
ARG A 315
ASN A 314
HIS A 344
 SO4  A 414 (-4.8A)
SO4  A 414 (-3.7A)
None
None
 1.34A 3frqA-3sszA:
undetectable		 3frqA-3sszA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 347
ARG A 292
ASN A 291
HIS A 321
 None
 1.31A 3frqA-3stpA:
undetectable		 3frqA-3stpA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ARG A 702
ASN A 701
HIS A 669
ALA A 626
 None
AMP  A 747 (-3.9A)
None
None
 1.28A 3frqA-3ttfA:
undetectable		 3frqA-3ttfA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tts BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 ARG A 106
ASN A 113
HIS A  85
ALA A  90
 None
 1.40A 3frqA-3ttsA:
undetectable		 3frqA-3ttsA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 ASN A  16
ARG A 317
ASN A 319
ALA A  30
 None
 1.42A 3frqA-3vv3A:
0.5		 3frqA-3vv3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wuc GALECTIN

(Xenopus laevis) 		PF00337
(Gal-bind_lectin) 		4 ASN A 125
ARG A  32
ASN A  31
ALA A  27
 MLA  A 203 (-3.9A)
GAL  A 202 (-2.8A)
None
None
 1.28A 3frqA-3wucA:
undetectable		 3frqA-3wucA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ASN A 394
ARG A 419
HIS A 520
ALA A 518
 None
 1.22A 3frqA-4a1oA:
undetectable		 3frqA-4a1oA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arx PESTICIDAL CRYSTAL
PROTEIN CRY1AC

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 194
ARG A 192
ASN A 138
HIS A 168
 None
 1.27A 3frqA-4arxA:
undetectable		 3frqA-4arxA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASN C 249
ARG C 164
ASN C 256
ALA C 153
 SO4  C1405 (-3.5A)
None
None
None
 1.41A 3frqA-4b3iC:
undetectable		 3frqA-4b3iC:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 ARG A  55
ASN A  56
HIS A  32
ALA A  33
 NAG  A 603 (-3.6A)
None
None
None
 1.23A 3frqA-4cyfA:
0.2		 3frqA-4cyfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3d IMINE REDUCTASE

(Bacillus cereus) 		PF03446
(NAD_binding_2) 		4 ASN A  90
ASN A 110
HIS A 133
ALA A 122
 None
 1.27A 3frqA-4d3dA:
undetectable		 3frqA-4d3dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 ASN A 242
ASN A 710
HIS A 706
ALA A 246
 None
 0.94A 3frqA-4fyeA:
0.0		 3frqA-4fyeA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		4 ASN A 387
ARG A 251
HIS A 331
ALA A 384
 None
 1.21A 3frqA-4j0wA:
undetectable		 3frqA-4j0wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		4 ASN A 370
ASN A 294
HIS A 350
ALA A 274
 None
 1.36A 3frqA-4k90A:
undetectable		 3frqA-4k90A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mae METHANOL
DEHYDROGENASE

(Methylacidiphilum
fumariolicum) 		PF13360
(PQQ_2) 		4 ASN A 256
ARG A 326
ASN A 304
HIS A 323
 CE  A 601 ( 3.4A)
PQQ  A 602 (-2.7A)
None
None
 1.49A 3frqA-4maeA:
undetectable		 3frqA-4maeA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Campylobacter
jejuni) 		PF00496
(SBP_bac_5) 		4 ASN A  97
ARG A  17
ASN A  19
ALA A  90
 None
 1.06A 3frqA-4oetA:
undetectable		 3frqA-4oetA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4osp OXYGENASE-REDUCTASE

(Streptomyces
fradiae) 		PF13561
(adh_short_C2) 		4 ASN A 182
ARG A 141
ASN A 186
ALA A 175
 None
 1.40A 3frqA-4ospA:
undetectable		 3frqA-4ospA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpz CYTOCHROME P450

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 ASN A 143
ASN A 172
HIS A 241
ALA A 245
 None
 1.41A 3frqA-4wpzA:
1.0		 3frqA-4wpzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydi ENVELOPE
GLYCOPROTEIN GP160
HEAVY CHAIN OF
ANTIBODY
Z258-VRC27.01

(Human
immunodeficiency
virus 1;
Homo sapiens) 		PF00516
(GP120)
PF07654
(C1-set)
PF07686
(V-set) 		4 ASN G 462
ARG G 456
ASN G 280
ALA H  60
 NAG  G 512 (-4.5A)
None
None
None
 1.23A 3frqA-4ydiG:
undetectable		 3frqA-4ydiG:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 4 ASN B 125
ARG B 262
HIS B 181
ALA B 189
 None
 1.32A 3frqA-5cwwB:
undetectable		 3frqA-5cwwB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 ASN A 510
ARG A 355
ASN A 429
HIS A 432
 MGT  A1676 (-3.5A)
MGT  A1676 (-3.4A)
MGT  A1676 (-3.6A)
None
 1.38A 3frqA-5fmqA:
1.0		 3frqA-5fmqA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxv HISTONE DEMETHYLASE
UTY

(Homo sapiens) 		PF02373
(JmjC) 		4 ASN A1287
ARG A1226
ASN A1223
ALA A1275
 None
 1.47A 3frqA-5fxvA:
undetectable		 3frqA-5fxvA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN
PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
PF08084
(PROCT) 		4 ASN B2055
ARG B2057
ASN A1059
ALA B2050
 None
 1.18A 3frqA-5m59B:
0.1		 3frqA-5m59B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3
26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C)
PF10075
(CSN8_PSD8_EIF3K) 		4 ASN T  93
ASN S 207
HIS S 191
ALA S 195
 None
 1.30A 3frqA-5mpdT:
undetectable		 3frqA-5mpdT:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A
METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D

(Methanothermococcus
thermolithotrophicus;
Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
PF02662
(FlpD) 		4 ARG A 100
ASN A  98
HIS A 102
ALA D  21
 SF4  A 705 (-4.1A)
None
None
None
 1.26A 3frqA-5odrA:
undetectable		 3frqA-5odrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASN A 323
ASN A   2
HIS A  23
ALA A 463
 None
 1.14A 3frqA-5ubkA:
undetectable		 3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASN A 323
ASN A  21
HIS A  23
ALA A 463
 None
 1.29A 3frqA-5ubkA:
undetectable		 3frqA-5ubkA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uke INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 3

(Homo sapiens) 		no annotation 4 ASN A   9
ARG A  75
HIS A  19
ALA A  12
 None
 0.99A 3frqA-5ukeA:
undetectable		 3frqA-5ukeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 ASN A 633
ARG A 629
ASN A 277
ALA A 678
 None
 1.50A 3frqA-5wugA:
undetectable		 3frqA-5wugA:
undetectable