SIMILAR PATTERNS OF AMINO ACIDS FOR 3FRE_X_TOPX300
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | ASP C 431LEU C 429VAL C 421PHE C 491THR C 152 | None | 1.05A | 3freX-1a5lC:undetectable | 3freX-1a5lC:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5l | UREASE (ALPHASUBUNIT) (Klebsiellaaerogenes) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 5 | ASP C 431LEU C 429VAL C 421SER C 509PHE C 491 | None | 1.15A | 3freX-1a5lC:undetectable | 3freX-1a5lC:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c0a | ASPARTYL TRNASYNTHETASE (Escherichiacoli) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 5 | ALA A 396LEU A 299VAL A 295SER A 366ILE A 352 | AMP A 800 (-4.1A)NoneNoneNoneNone | 1.13A | 3freX-1c0aA:undetectable | 3freX-1c0aA:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 5 | ALA A 9LEU A 22SER A 59ILE A 60THR A 136 | HBI A 198 ( 3.6A)NAP A 191 ( 4.7A)NAP A 191 ( 4.1A)NoneHBI A 198 ( 4.5A) | 0.91A | 3freX-1dr6A:20.2 | 3freX-1dr6A:27.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g1a | DTDP-D-GLUCOSE4,6-DEHYDRATASE (Salmonellaenterica) |
PF16363(GDP_Man_Dehyd) | 5 | VAL A 77SER A 62ILE A 65PHE A 69THR A 189 | None | 1.16A | 3freX-1g1aA:undetectable | 3freX-1g1aA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ge9 | RIBOSOME RECYCLINGFACTOR (Aquifexaeolicus) |
PF01765(RRF) | 5 | ALA A 35LEU A 39LEU A 89VAL A 102ILE A 43 | None | 1.23A | 3freX-1ge9A:undetectable | 3freX-1ge9A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m66 | GLYCEROL-3-PHOSPHATEDEHYDROGENASE (Leishmaniamexicana) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 5 | LEU A 151LEU A 30VAL A 33ILE A 88THR A 166 | None | 0.99A | 3freX-1m66A:undetectable | 3freX-1m66A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o1y | CONSERVEDHYPOTHETICAL PROTEINTM1158 (Thermotogamaritima) |
PF00117(GATase) | 5 | LEU A 221LEU A 85VAL A 168ILE A 174PHE A 125 | None | 1.07A | 3freX-1o1yA:undetectable | 3freX-1o1yA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o6e | CAPSID PROTEIN P40 (Humangammaherpesvirus4) |
PF00716(Peptidase_S21) | 5 | ALA A 52LEU A 201LEU A 112ILE A 85THR A 45 | None | 1.29A | 3freX-1o6eA:undetectable | 3freX-1o6eA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ooe | DIHYDROPTERIDINEREDUCTASE (Caenorhabditiselegans) |
PF00106(adh_short) | 5 | ALA A 112LEU A 164LEU A 119VAL A 76SER A 218 | None | 1.29A | 3freX-1ooeA:undetectable | 3freX-1ooeA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pca | PROCARBOXYPEPTIDASEA PCPA (Sus scrofa) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | ALA A 63LEU A 29LEU A 35VAL A 56ILE A 15 | None | 1.26A | 3freX-1pcaA:undetectable | 3freX-1pcaA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pyt | PROCARBOXYPEPTIDASEA (Bos taurus) |
PF02244(Propep_M14) | 5 | ALA A 63LEU A 29LEU A 35VAL A 56ILE A 15 | None | 1.27A | 3freX-1pytA:undetectable | 3freX-1pytA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qc5 | PROTEIN (ALPHA1BETA1 INTEGRIN) (Homo sapiens) |
PF00092(VWA) | 5 | LEU B 359VAL B 395ILE B 402PHE B 384THR B 369 | None | 1.28A | 3freX-1qc5B:undetectable | 3freX-1qc5B:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qmv | PEROXIREDOXIN-2 (Homo sapiens) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 5 | LEU A 96ASP A 46SER A 59ILE A 101THR A 82 | None | 1.22A | 3freX-1qmvA:undetectable | 3freX-1qmvA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x3l | HYPOTHETICAL PROTEINPH0495 (Pyrococcushorikoshii) |
PF05161(MOFRL)PF13660(DUF4147) | 5 | ALA A 112LEU A 181LEU A 56VAL A 79SER A 174 | None | 1.29A | 3freX-1x3lA:undetectable | 3freX-1x3lA:16.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 5 | ALA A 7LEU A 20ASP A 27ILE A 50THR A 115 | NoneNoneNoneSO4 A3486 ( 4.8A)None | 0.66A | 3freX-1zdrA:26.0 | 3freX-1zdrA:48.77 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 5 | ALA A 7LEU A 20ASP A 27LEU A 28THR A 115 | NoneNoneNoneSO4 A3486 ( 4.8A)None | 0.58A | 3freX-1zdrA:26.0 | 3freX-1zdrA:48.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 6 | ALA A 15LEU A 45ASP A 53SER A 120ILE A 121THR A 194 | CP7 A1240 (-3.7A)NDP A1239 (-4.8A)CP7 A1240 (-3.1A)NDP A1239 (-3.6A)MES A1241 ( 4.1A)CP7 A1240 (-4.1A) | 0.83A | 3freX-2blbA:19.7 | 3freX-2blbA:28.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2boa | CARBOXYPEPTIDASE A4 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 5 | ALA A 63LEU A 29LEU A 35VAL A 56ILE A 15 | None | 1.29A | 3freX-2boaA:undetectable | 3freX-2boaA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cex | PROTEIN HI0146 (Haemophilusinfluenzae) |
PF03480(DctP) | 5 | ALA A 93ASP A 213LEU A 215ILE A 107PHE A 98 | None | 1.17A | 3freX-2cexA:undetectable | 3freX-2cexA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4e | 5-CARBOXYMETHYL-2-HYDROXYMUCONATESEMIALDEHYDEDEHYDROGENASE (Thermusthermophilus) |
PF00171(Aldedh) | 5 | LEU A 92LEU A 217VAL A 221ILE A 183THR A 83 | None | 1.06A | 3freX-2d4eA:undetectable | 3freX-2d4eA:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dmz | INAD-LIKE PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ALA A 94LEU A 29LEU A 100VAL A 74ILE A 33 | None | 1.19A | 3freX-2dmzA:undetectable | 3freX-2dmzA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | ALA A 143LEU A 79VAL A 80SER A 117PHE A 125 | None | 1.07A | 3freX-2ecfA:undetectable | 3freX-2ecfA:12.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 28ASP A 48SER A 83ILE A 84THR A 178 | NAP A 523 (-3.7A)NoneNAP A 523 ( 4.4A)NoneNone | 0.92A | 3freX-2h2qA:19.2 | 3freX-2h2qA:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilu | ALDEHYDEDEHYDROGENASE A (Escherichiacoli) |
PF00171(Aldedh) | 5 | LEU A 167LEU A 197VAL A 192ILE A 112PHE A 188 | None | 1.25A | 3freX-2iluA:undetectable | 3freX-2iluA:15.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jik | SYNAPTOJANIN-2BINDING PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ALA A 88LEU A 23LEU A 94VAL A 68ILE A 27 | None | 1.12A | 3freX-2jikA:undetectable | 3freX-2jikA:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lf8 | TRANSCRIPTION FACTORETV6 (Mus musculus) |
PF00178(Ets) | 5 | LEU A 394LEU A 337VAL A 341ILE A 402PHE A 415 | None | 1.06A | 3freX-2lf8A:undetectable | 3freX-2lf8A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzb | ADENOSYLCOBINAMIDE-PHOSPHATEGUANYLYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF12804(NTP_transf_3) | 5 | ALA A 48ASP A 83LEU A 84PHE A 95THR A 75 | None | 1.11A | 3freX-2mzbA:2.1 | 3freX-2mzbA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o1b | AMINOTRANSFERASE,CLASS I (Staphylococcusaureus) |
PF00155(Aminotran_1_2) | 5 | ALA A 273LEU A 231VAL A 242ILE A 74PHE A 70 | None | 1.15A | 3freX-2o1bA:undetectable | 3freX-2o1bA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 5 | LEU 1 381VAL 1 383SER 1 362ILE 1 264PHE 1 351 | None | 1.20A | 3freX-2oap1:undetectable | 3freX-2oap1:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 7 | ALA A 11LEU A 25ASP A 32LEU A 33SER A 61ILE A 62THR A 134 | MTX A 605 ( 3.6A)MTX A 605 ( 4.6A)MTX A 605 ( 3.0A)MTX A 605 ( 4.0A)NDP A 606 ( 4.5A)MTX A 605 ( 4.6A)MTX A 605 ( 4.2A) | 0.71A | 3freX-2oipA:21.4 | 3freX-2oipA:17.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qk8 | DIHYDROFOLATEREDUCTASE (Bacillusanthracis) |
PF00186(DHFR_1) | 7 | ALA A 8LEU A 21LEU A 29VAL A 32ILE A 51PHE A 96THR A 115 | MTX A 200 ( 3.4A)MTX A 200 ( 4.5A)MTX A 200 ( 4.3A)MTX A 200 ( 4.7A)MTX A 200 ( 4.2A)MTX A 200 ( 3.9A)MTX A 200 ( 4.4A) | 0.78A | 3freX-2qk8A:25.1 | 3freX-2qk8A:45.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyv | XAA-HIS DIPEPTIDASE (Histophilussomni) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ALA A 123LEU A 137LEU A 480SER A 162ILE A 164 | None | 1.28A | 3freX-2qyvA:undetectable | 3freX-2qyvA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rh7 | GREEN FLUORESCENTPROTEIN (Renillareniformis) |
PF01353(GFP) | 5 | ALA A 57LEU A 129VAL A 22ILE A 97PHE A 124 | None | 1.22A | 3freX-2rh7A:undetectable | 3freX-2rh7A:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v0s | LR1 (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | LEU A 129LEU A 172VAL A 206PHE A 146THR A 140 | None | 1.26A | 3freX-2v0sA:undetectable | 3freX-2v0sA:22.32 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 5 | ALA A 11ASP A 31LEU A 32SER A 53THR A 121 | VG9 A1168 ( 3.8A)VG9 A1168 (-3.0A)VG9 A1168 (-4.7A)NDP A1169 ( 3.9A)VG9 A1168 ( 4.7A) | 0.83A | 3freX-2w3wA:22.6 | 3freX-2w3wA:31.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 8 | ALA A 7LEU A 20ASP A 27LEU A 28SER A 49ILE A 50PHE A 92THR A 111 | TOP A1160 ( 3.6A)TOP A1160 ( 4.2A)TOP A1160 (-2.8A)TOP A1160 ( 4.6A)TOP A1160 (-3.5A)TOP A1160 (-4.4A)TOP A1160 ( 3.9A)TOP A1160 ( 4.5A) | 0.43A | 3freX-2w9sA:30.1 | 3freX-2w9sA:80.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b33 | SENSOR PROTEIN (Vibrioparahaemolyticus) |
PF00989(PAS) | 5 | ALA A 16LEU A 89VAL A 91ILE A 53THR A 15 | None | 1.02A | 3freX-3b33A:undetectable | 3freX-3b33A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ca8 | PROTEIN YDCF (Escherichiacoli) |
PF02698(DUF218) | 5 | LEU A 256LEU A 209VAL A 205SER A 10ILE A 14 | None | 1.26A | 3freX-3ca8A:undetectable | 3freX-3ca8A:18.99 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 6 | ALA A 6LEU A 19ASP A 26LEU A 27SER A 48THR A 116 | MTX A 164 (-3.8A)MTX A 164 (-4.5A)MTX A 164 ( 2.9A)MTX A 164 ( 4.5A)MTX A 164 (-3.5A)MTX A 164 ( 4.3A) | 0.67A | 3freX-3dfrA:23.9 | 3freX-3dfrA:35.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 6 | ALA A 16LEU A 46ASP A 54SER A 111ILE A 112THR A 185 | RJ6 A 609 (-3.7A)RJ6 A 609 (-3.8A)RJ6 A 609 (-3.0A)RJ6 A 609 ( 3.8A)RJ6 A 609 (-4.8A)RJ6 A 609 ( 4.5A) | 0.83A | 3freX-3dg8A:20.2 | 3freX-3dg8A:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhc | NUCLEAR PORE COMPLEXPROTEIN NUP214 (Homo sapiens) |
PF12894(ANAPC4_WD40) | 5 | LEU A 144LEU A 177VAL A 165SER A 173ILE A 174 | None | 0.96A | 3freX-3fhcA:undetectable | 3freX-3fhcA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g04 | THYROTROPIN RECEPTOR (Homo sapiens) |
PF13306(LRR_5) | 5 | LEU C 246LEU C 231VAL C 205ILE C 216PHE C 197 | None | 1.09A | 3freX-3g04C:undetectable | 3freX-3g04C:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hs0 | COBRA VENOM FACTOR (Naja kaouthia) |
PF01835(A2M_N)PF07703(A2M_N_2) | 5 | ALA A 374LEU A 376ILE A 389PHE A 325THR A 368 | None | 1.26A | 3freX-3hs0A:undetectable | 3freX-3hs0A:14.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 8 | ALA X 7LEU X 20ASP X 27LEU X 28VAL X 31ILE X 50PHE X 92THR X 111 | N22 X 219 ( 3.6A)N22 X 219 ( 4.6A)N22 X 219 (-2.8A)N22 X 219 (-4.4A)NoneN22 X 219 (-4.6A)N22 X 219 ( 3.7A)N22 X 219 (-4.4A) | 0.54A | 3freX-3i8aX:30.9 | 3freX-3i8aX:98.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 8 | ALA X 7LEU X 20ASP X 27VAL X 31SER X 49ILE X 50PHE X 92THR X 111 | N22 X 219 ( 3.6A)N22 X 219 ( 4.6A)N22 X 219 (-2.8A)NoneN22 X 219 (-3.3A)N22 X 219 (-4.6A)N22 X 219 ( 3.7A)N22 X 219 (-4.4A) | 0.58A | 3freX-3i8aX:30.9 | 3freX-3i8aX:98.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ia4 | DIHYDROFOLATEREDUCTASE (Moritellaprofunda) |
PF00186(DHFR_1) | 5 | ALA A 8LEU A 29SER A 50ILE A 51THR A 115 | MTX A 164 ( 3.7A)MTX A 164 (-4.0A)NDP A 163 ( 3.8A)MTX A 164 (-4.1A)MTX A 164 (-4.3A) | 0.56A | 3freX-3ia4A:25.7 | 3freX-3ia4A:39.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kip | 3-DEHYDROQUINASE,TYPE II (Candidaalbicans) |
PF01220(DHquinase_II) | 5 | ALA A 78LEU A 12VAL A 102ILE A 31THR A 82 | None | 1.26A | 3freX-3kipA:undetectable | 3freX-3kipA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 16ASP A 37SER A 72ILE A 73THR A 144 | NAP A 512 (-3.7A)NoneNAP A 512 ( 4.2A)NoneNone | 0.84A | 3freX-3kjrA:20.6 | 3freX-3kjrA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ktn | CARBOHYDRATE KINASE,PFKB FAMILY (Enterococcusfaecalis) |
PF00294(PfkB) | 5 | ALA A 301LEU A 254ILE A 194PHE A 196THR A 302 | None | 1.29A | 3freX-3ktnA:undetectable | 3freX-3ktnA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la4 | UREASE (Canavaliaensiformis) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | ASP A 704LEU A 702VAL A 694PHE A 764THR A 425 | None | 0.97A | 3freX-3la4A:undetectable | 3freX-3la4A:10.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o44 | HEMOLYSIN (Vibrio cholerae) |
PF07968(Leukocidin)PF12563(Hemolysin_N)PF16458(Beta-prism_lec) | 5 | ALA A 583LEU A 188VAL A 186SER A 398PHE A 446 | None | 1.29A | 3freX-3o44A:undetectable | 3freX-3o44A:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p04 | UNCHARACTERIZED BCR (Corynebacteriumglutamicum) |
PF04472(SepF) | 5 | ALA A 86LEU A 115VAL A 133ILE A 108PHE A 95 | None | 1.19A | 3freX-3p04A:undetectable | 3freX-3p04A:16.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpm | PEROXIREDOXIN (Larimichthyscrocea) |
PF00578(AhpC-TSA)PF10417(1-cysPrx_C) | 5 | LEU A 158ASP A 108SER A 121ILE A 163THR A 144 | None | 1.19A | 3freX-3qpmA:undetectable | 3freX-3qpmA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s5k | FALCILYSIN (Plasmodiumfalciparum) |
PF00675(Peptidase_M16)PF05193(Peptidase_M16_C)PF08367(M16C_assoc) | 5 | LEU A 431LEU A 490VAL A 493ILE A 419PHE A 498 | None | 1.22A | 3freX-3s5kA:undetectable | 3freX-3s5kA:10.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tpa | HEME-BINDING PROTEINA (Glaesserellaparasuis) |
PF00496(SBP_bac_5) | 5 | LEU A 146VAL A 157SER A 64ILE A 63PHE A 72 | None | 1.02A | 3freX-3tpaA:undetectable | 3freX-3tpaA:16.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 7 | ALA A 8LEU A 21ASP A 28LEU A 29SER A 50ILE A 51THR A 115 | MTX A2001 ( 3.4A)MTX A2001 (-4.4A)MTX A2001 (-2.7A)MTX A2001 (-3.9A)NDP A1001 ( 3.0A)MTX A2001 (-4.3A)MTX A2001 (-4.3A) | 0.57A | 3freX-3tq9A:25.2 | 3freX-3tq9A:38.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 5 | ALA A 8ASP A 28SER A 56ILE A 57THR A 133 | None | 0.97A | 3freX-3vcoA:17.6 | 3freX-3vcoA:28.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmy | EXTRACELLULAREXO-ALPHA-L-ARABINOFURANOSIDASE (Streptomycescoelicolor) |
PF03664(Glyco_hydro_62) | 5 | LEU A 178LEU A 446VAL A 441SER A 390ILE A 377 | None | 0.97A | 3freX-3wmyA:undetectable | 3freX-3wmyA:15.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wvs | PUTATIVEMONOOXYGENASE (Streptomycessp. SN-593) |
PF00067(p450) | 5 | ALA A 58LEU A 38VAL A 314ILE A 301PHE A 67 | None | 1.23A | 3freX-3wvsA:undetectable | 3freX-3wvsA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zrp | SERINE-PYRUVATEAMINOTRANSFERASE(AGXT) (Sulfolobussolfataricus) |
PF00266(Aminotran_5) | 5 | ALA A 66LEU A 223LEU A 202VAL A 182SER A 215 | None | 1.18A | 3freX-3zrpA:undetectable | 3freX-3zrpA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7e | UREASE (Cajanus cajan) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 5 | ASP B 704LEU B 702VAL B 694PHE B 764THR B 425 | None | 0.97A | 3freX-4g7eB:undetectable | 3freX-4g7eB:10.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 5 | ALA X 12LEU X 25SER X 64ILE X 65THR X 144 | NDP X 302 ( 3.8A)TOP X 301 ( 4.0A)TOP X 301 (-3.3A)TOP X 301 ( 4.3A)TOP X 301 (-4.5A) | 0.56A | 3freX-4g8zX:20.0 | 3freX-4g8zX:29.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h05 | AMINOGLYCOSIDE-O-PHOSPHOTRANSFERASE VIII (Streptomycesrimosus) |
PF01636(APH) | 5 | ALA A 94LEU A 185VAL A 220SER A 116PHE A 240 | None | 1.18A | 3freX-4h05A:undetectable | 3freX-4h05A:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6x | THIAZOLINEOXIDASE/SUBTILISIN-LIKE PROTEASE (Prochlorondidemni) |
PF00082(Peptidase_S8) | 5 | ALA A 844LEU A 796VAL A 839ILE A 637THR A 819 | None | 1.15A | 3freX-4h6xA:undetectable | 3freX-4h6xA:18.08 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 5 | ALA A 11LEU A 25SER A 61ILE A 62THR A 140 | 14Q A 302 ( 3.4A)14Q A 302 ( 4.1A)14Q A 302 (-2.6A)14Q A 302 (-4.2A)14Q A 302 (-4.2A) | 0.57A | 3freX-4h98A:19.4 | 3freX-4h98A:31.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jbu | VIRULENCE-ASSOCIATEDV ANTIGEN (Yersinia pestis) |
PF04792(LcrV) | 5 | LEU A 253LEU A 280VAL A 284SER A 235ILE A 236 | None | 1.12A | 3freX-4jbuA:undetectable | 3freX-4jbuA:18.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l8l | 3-DEHYDROQUINATEDEHYDRATASE 1 (Pseudomonasaeruginosa) |
PF01220(DHquinase_II) | 5 | LEU A 12LEU A 102VAL A 100ILE A 31THR A 80 | None | 1.17A | 3freX-4l8lA:undetectable | 3freX-4l8lA:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lr2 | BIS(5'-ADENOSYL)-TRIPHOSPHATASE ENPP4 (Homo sapiens) |
PF01663(Phosphodiest) | 5 | ALA A 90ASP A 264VAL A 268ILE A 299PHE A 66 | None | 0.93A | 3freX-4lr2A:undetectable | 3freX-4lr2A:16.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4m7v | DIHYDROFOLATEREDUCTASE (Enterococcusfaecalis) |
PF00186(DHFR_1) | 5 | ALA A 7LEU A 20ASP A 27LEU A 28THR A 116 | RAR A 200 ( 3.6A)RAR A 200 ( 3.7A)RAR A 200 (-2.6A)RAR A 200 (-3.8A)RAR A 200 (-4.4A) | 0.29A | 3freX-4m7vA:25.4 | 3freX-4m7vA:43.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mzw | GLUTATHIONES-TRANSFERASE (Streptococcussanguinis) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | ALA A 123LEU A 119LEU A 144VAL A 140SER A 211 | None | 1.21A | 3freX-4mzwA:undetectable | 3freX-4mzwA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8o | ALPHA-L-ARABINOFURANOSIDASE (Streptomycesthermoviolaceus) |
PF03664(Glyco_hydro_62) | 5 | LEU A 64LEU A 334VAL A 329SER A 278ILE A 264 | None | 0.96A | 3freX-4o8oA:undetectable | 3freX-4o8oA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oq1 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
no annotation | 5 | ALA A 141LEU A 52VAL A 110ILE A 103PHE A 127 | None | 1.24A | 3freX-4oq1A:undetectable | 3freX-4oq1A:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxx | CINDOXIN (Citrobacterbraakii) |
PF00258(Flavodoxin_1) | 5 | LEU A 82LEU A 45ILE A 52PHE A 71THR A 78 | None | 1.16A | 3freX-4oxxA:2.2 | 3freX-4oxxA:19.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4p68 | DIHYDROFOLATEREDUCTASE (Escherichiacoli) |
PF00186(DHFR_1) | 5 | ALA A 7ASP A 27SER A 49ILE A 50THR A 113 | MTX A 201 ( 4.0A)MTX A 201 (-3.0A)MTX A 201 ( 3.7A)MTX A 201 (-4.7A)MTX A 201 ( 4.5A) | 0.52A | 3freX-4p68A:25.9 | 3freX-4p68A:36.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2n | INAD-LIKE PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | ALA A 441LEU A 376LEU A 447VAL A 421ILE A 380 | None | 0.91A | 3freX-4q2nA:undetectable | 3freX-4q2nA:24.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qax | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Staphylococcusaureus) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | ALA A 287LEU A 97LEU A 132SER A 85ILE A 82 | None | 1.28A | 3freX-4qaxA:undetectable | 3freX-4qaxA:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlb | PROBABLE GLYCOGEN[STARCH] SYNTHASE (Caenorhabditiselegans) |
PF05693(Glycogen_syn) | 5 | ALA A 392ASP A 475LEU A 478VAL A 477SER A 401 | None | 1.10A | 3freX-4qlbA:undetectable | 3freX-4qlbA:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qpp | PROTEIN ARGININEN-METHYLTRANSFERASE6 (Homo sapiens) |
PF13649(Methyltransf_25) | 5 | ALA A 173LEU A 87LEU A 145VAL A 143SER A 97 | None | 1.29A | 3freX-4qppA:undetectable | 3freX-4qppA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r1n | 3-HYDROXYBUTYRYL-COADEHYDROGENASE (Clostridiumbutyricum) |
PF00725(3HCDH)PF02737(3HCDH_N) | 5 | LEU A 83VAL A 85SER A 171ILE A 172PHE A 139 | None | 1.28A | 3freX-4r1nA:undetectable | 3freX-4r1nA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8f | VACUOLARAMINOPEPTIDASE 1 (Saccharomycescerevisiae) |
PF02127(Peptidase_M18) | 5 | ALA A 422LEU A 310VAL A 84SER A 318THR A 424 | None | 1.28A | 3freX-4r8fA:undetectable | 3freX-4r8fA:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 5 | ALA A 221LEU A 376LEU A 201VAL A 197PHE A 226 | None | 1.18A | 3freX-4tvmA:undetectable | 3freX-4tvmA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dst | PROTEIN ARGININEN-METHYLTRANSFERASE8 (Homo sapiens) |
PF06325(PrmA) | 5 | ALA A 203LEU A 116LEU A 174VAL A 172SER A 126 | None | 1.27A | 3freX-5dstA:undetectable | 3freX-5dstA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ezr | CGMP-DEPENDENTPROTEIN KINASE,PUTATIVE (Plasmodiumvivax) |
PF00027(cNMP_binding)PF00069(Pkinase) | 5 | ALA A 622LEU A 665SER A 640ILE A 641PHE A 722 | None | 1.26A | 3freX-5ezrA:undetectable | 3freX-5ezrA:10.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ful | PROTEIN ARGININEN-METHYLTRANSFERASE2 (Mus musculus) |
PF05175(MTS) | 5 | ALA A 241LEU A 154LEU A 213VAL A 211SER A 164 | None | 1.22A | 3freX-5fulA:undetectable | 3freX-5fulA:14.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gle | ISCHORISMATE LYASE (Vibrioanguillarum) |
no annotation | 5 | ALA A 176LEU A 43LEU A 57VAL A 60ILE A 105 | None | 0.85A | 3freX-5gleA:undetectable | 3freX-5gleA:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzh | ENDO-BETA-1,2-GLUCANASE (Chitinophagapinensis) |
PF10091(Glycoamylase) | 5 | LEU A 282LEU A 430VAL A 426ILE A 214PHE A 420 | None | 1.18A | 3freX-5gzhA:undetectable | 3freX-5gzhA:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iaa | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 5 (Homo sapiens) |
PF00899(ThiF) | 5 | LEU A 135LEU A 102VAL A 81PHE A 118THR A 88 | None | 1.11A | 3freX-5iaaA:undetectable | 3freX-5iaaA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5loq | PUTATIVEHEME-DEPENDENTPEROXIDASE LMO2113 (Listeriamonocytogenes) |
PF06778(Chlor_dismutase) | 5 | LEU A 245LEU A 70ILE A 94PHE A 89THR A 59 | None | 1.16A | 3freX-5loqA:undetectable | 3freX-5loqA:23.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lts | RNA-DIRECTED RNAPOLYMERASE L (Lymphocyticchoriomeningitismammarenavirus) |
PF17296(ArenaCapSnatch) | 5 | LEU A 82LEU A 129VAL A 134SER A 67ILE A 71 | None | 1.14A | 3freX-5ltsA:undetectable | 3freX-5ltsA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mpd | 26S PROTEASOMEREGULATORY SUBUNITRPN10 (Saccharomycescerevisiae) |
PF13519(VWA_2) | 5 | ALA W 94LEU W 91LEU W 132VAL W 137ILE W 158 | None | 1.25A | 3freX-5mpdW:undetectable | 3freX-5mpdW:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5olp | PECTATE LYASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | ALA A 67VAL A 91SER A 147ILE A 146PHE A 93 | None | 1.13A | 3freX-5olpA:undetectable | 3freX-5olpA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 10LEU A 23ASP A 31SER A 86THR A 172 | 73X A 704 (-4.0A)None73X A 704 (-2.8A)NDP A 702 (-3.8A)73X A 704 (-4.2A) | 0.81A | 3freX-5t0lA:20.7 | 3freX-5t0lA:15.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t13 | CYANURIC ACIDAMIDOHYDROLASE (Enterobactercloacae) |
PF09663(Amido_AtzD_TrzD) | 5 | ALA A 57VAL A 36ILE A 23PHE A 62THR A 54 | None | 1.15A | 3freX-5t13A:undetectable | 3freX-5t13A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t81 | EPOB (Sorangiumcellulosum) |
PF00668(Condensation) | 5 | LEU A 430LEU A 198VAL A 184ILE A 213PHE A 115 | None | 0.96A | 3freX-5t81A:undetectable | 3freX-5t81A:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veo | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Mus musculus) |
PF01663(Phosphodiest) | 5 | ALA A 92ASP A 265VAL A 269ILE A 301PHE A 68 | None | 0.92A | 3freX-5veoA:undetectable | 3freX-5veoA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y2v | RUBISCO OPERONTRANSCRIPTIONALREGULATOR (Synechocystissp. PCC 6803) |
no annotation | 5 | ALA A 204VAL A 240ILE A 184PHE A 209THR A 201 | NoneNoneNoneNonePO4 A 401 (-4.0A) | 1.20A | 3freX-5y2vA:undetectable | 3freX-5y2vA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 8 | ALA A 7LEU A 20ASP A 27LEU A 28VAL A 31ILE A 50PHE A 92THR A 111 | MMV A 202 ( 3.5A)MMV A 202 (-4.3A)MMV A 202 (-2.9A)MMV A 202 (-4.2A)MMV A 202 (-4.9A)MMV A 202 ( 4.9A)MMV A 202 ( 3.5A)MMV A 202 (-4.3A) | 0.44A | 3freX-6e4eA:30.9 | 3freX-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 8 | ALA A 7LEU A 20ASP A 27VAL A 31SER A 49ILE A 50PHE A 92THR A 111 | MMV A 202 ( 3.5A)MMV A 202 (-4.3A)MMV A 202 (-2.9A)MMV A 202 (-4.9A)NAP A 201 (-4.2A)MMV A 202 ( 4.9A)MMV A 202 ( 3.5A)MMV A 202 (-4.3A) | 0.52A | 3freX-6e4eA:30.9 | 3freX-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0k | ACTFPOLYSULPHIDEREDUCTASE NRFD (Rhodothermusmarinus) |
no annotation | 5 | ALA C 273SER F 288ILE F 285PHE F 281THR C 315 | None | 1.22A | 3freX-6f0kC:undetectable | 3freX-6f0kC:18.42 |