SIMILAR PATTERNS OF AMINO ACIDS FOR 3FPJ_B_SAMB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 GLY A  53
GLY A  48
THR A  43
ALA A  57
 None
 0.82A 3fpjB-1fpsA:
undetectable		 3fpjB-1fpsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY B 304
GLY B 302
THR B 267
ALA B 143
 None
 0.75A 3fpjB-1h4vB:
undetectable		 3fpjB-1h4vB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 GLY A  42
GLY A  87
THR A  57
ALA A  45
 None
 0.87A 3fpjB-1idmA:
undetectable		 3fpjB-1idmA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A  69
GLY A  65
THR A  60
ALA A  71
 None
 0.78A 3fpjB-1ik6A:
2.9		 3fpjB-1ik6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  98
GLY A 100
THR A 104
GLU A 121
 None
 0.74A 3fpjB-1inlA:
9.7		 3fpjB-1inlA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 GLY A  57
THR A 158
GLU A  60
GLU A  66
 None
 0.72A 3fpjB-1ir6A:
3.6		 3fpjB-1ir6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 GLY A 480
GLY A 450
GLU A 304
ALA A 483
 WCC  A 800 ( 4.4A)
WCC  A 800 (-4.1A)
None
None
 0.83A 3fpjB-1jqkA:
2.4		 3fpjB-1jqkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		4 GLY A 208
GLY A  97
GLU A  40
ALA A  44
 None
 0.87A 3fpjB-1oa4A:
undetectable		 3fpjB-1oa4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 421
GLY A 417
GLU A 426
ALA A  23
 None
 0.87A 3fpjB-1qlbA:
undetectable		 3fpjB-1qlbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  11
GLY A  14
THR A  20
ALA A 100
 NDP  A 400 (-3.1A)
NDP  A 400 (-3.8A)
None
None
 0.86A 3fpjB-1r0lA:
4.7		 3fpjB-1r0lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 191
GLY A 189
THR A 297
ALA A 307
 None
 0.86A 3fpjB-1u0mA:
undetectable		 3fpjB-1u0mA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 GLY A 148
GLY A 152
GLU A 143
ALA A 124
 None
 0.84A 3fpjB-1xw8A:
undetectable		 3fpjB-1xw8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 4 GLY A 182
GLU A 185
GLU A  47
ALA A  41
 None
 0.85A 3fpjB-1y8aA:
2.1		 3fpjB-1y8aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 GLY A 226
GLY A 223
GLU A 231
GLU A  99
 None
 0.88A 3fpjB-2bwpA:
2.3		 3fpjB-2bwpA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  12
GLY A 307
THR A  19
GLU A  32
 None
None
None
FAD  A 500 (-2.6A)
 0.82A 3fpjB-2cduA:
3.8		 3fpjB-2cduA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		4 GLY A 274
GLY A 272
GLU A 136
ALA A 348
 None
 0.66A 3fpjB-2csgA:
undetectable		 3fpjB-2csgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 GLN X  27
GLY X 107
GLY X 105
THR X 179
GLU X 160
 None
 1.14A 3fpjB-2dchX:
undetectable		 3fpjB-2dchX:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 GLY A  18
GLY A  12
GLU A 201
ALA A  22
 None
CO  A1001 (-3.6A)
None
None
 0.88A 3fpjB-2ehdA:
7.3		 3fpjB-2ehdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 195
THR A 165
GLU A 156
ALA A 149
 None
 0.81A 3fpjB-2gp6A:
undetectable		 3fpjB-2gp6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 GLY A 177
GLY A 175
THR A 124
ALA A 179
 None
 0.87A 3fpjB-2gr9A:
5.6		 3fpjB-2gr9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 GLY A 305
GLY A 303
GLU A 341
ALA A 327
 None
FMN  A1401 (-4.1A)
None
None
 0.79A 3fpjB-2h8xA:
undetectable		 3fpjB-2h8xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLY A 217
THR A 278
GLU A 218
ALA A 214
 None
 0.78A 3fpjB-2i4nA:
undetectable		 3fpjB-2i4nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLY A 407
GLY A 236
THR A 233
ALA A 411
 None
 0.81A 3fpjB-2iyaA:
4.7		 3fpjB-2iyaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liw CURA

(Lyngbya
majuscula) 		PF00550
(PP-binding) 		4 GLY A1992
THR A1998
GLU A1975
ALA A1968
 None
 0.85A 3fpjB-2liwA:
undetectable		 3fpjB-2liwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 GLY A  40
GLY A  21
GLU A  61
ALA A  58
 CA  A 203 ( 4.1A)
CA  A 201 (-4.7A)
None
None
 0.87A 3fpjB-2ml1A:
undetectable		 3fpjB-2ml1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 130
GLY A 133
GLU A 332
ALA A 336
 None
 0.87A 3fpjB-2pozA:
undetectable		 3fpjB-2pozA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 GLY A  11
THR A  19
GLU A  34
ALA A 203
 FAD  A 401 ( 3.3A)
None
FAD  A 401 ( 2.8A)
None
 0.77A 3fpjB-2q6uA:
4.6		 3fpjB-2q6uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE

(Deinococcus
radiodurans) 		PF07992
(Pyr_redox_2) 		4 GLY A  20
GLY A 300
THR A  27
GLU A  38
 None
None
None
FAD  A 348 (-2.7A)
 0.86A 3fpjB-2q7vA:
4.0		 3fpjB-2q7vA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 GLY A 171
THR A 149
GLU A 179
ALA A 174
 None
 0.72A 3fpjB-2we8A:
7.2		 3fpjB-2we8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A   7
GLY A   9
THR A  15
ALA A  83
 None
 0.78A 3fpjB-2y0eA:
8.4		 3fpjB-2y0eA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 219
THR A 227
GLU A 243
ALA A 299
 None
 0.70A 3fpjB-2yfqA:
4.8		 3fpjB-2yfqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 GLY A  17
GLY A  19
GLU A  41
ALA A  73
 None
 0.74A 3fpjB-3c24A:
5.5		 3fpjB-3c24A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 GLY B 113
GLY B 109
GLU B 118
ALA B 148
 None
 0.83A 3fpjB-3c6qB:
undetectable		 3fpjB-3c6qB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLN X 185
GLY X 181
GLU X  42
ALA X 144
 None
 0.78A 3fpjB-3e13X:
undetectable		 3fpjB-3e13X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		4 GLY A 216
GLY A 278
GLU A 150
ALA A 222
 None
 0.66A 3fpjB-3e73A:
undetectable		 3fpjB-3e73A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		4 GLY A 285
GLY A 287
GLU A 323
ALA A 326
 None
PG4  A   5 ( 4.4A)
None
None
 0.82A 3fpjB-3h41A:
undetectable		 3fpjB-3h41A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLY A   9
THR A   6
GLU A  77
ALA A 104
 None
 0.81A 3fpjB-3h4iA:
4.4		 3fpjB-3h4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		4 GLY A  97
GLY A 125
GLU A  42
ALA A 104
 None
 0.85A 3fpjB-3hzuA:
undetectable		 3fpjB-3hzuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLY A  49
THR A  53
GLU A  70
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.4A)
SAM  A 200 (-2.7A)
 0.60A 3fpjB-3ihtA:
9.0		 3fpjB-3ihtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 GLN X 253
GLY X 207
GLY X 219
ALA X 191
 None
 0.69A 3fpjB-3n5nX:
undetectable		 3fpjB-3n5nX:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		7 GLN A  81
GLY A 130
GLY A 132
THR A 137
GLU A 153
GLU A 181
ALA A 195
 3O3  A   1 ( 4.8A)
None
None
BR  A 298 (-4.0A)
None
None
3O3  A   1 (-3.5A)
 0.30A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 GLY A 163
GLY A 118
THR A  22
ALA A  27
 None
ATP  A 763 (-2.9A)
None
None
 0.78A 3fpjB-3o8lA:
2.0		 3fpjB-3o8lA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		5 GLN A 260
GLY A 266
GLU A 273
GLU A  26
ALA A 306
 None
 1.38A 3fpjB-3pt5A:
2.1		 3fpjB-3pt5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLY A  40
GLY A 120
GLU A 237
ALA A 188
 None
 0.81A 3fpjB-3q9oA:
undetectable		 3fpjB-3q9oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 GLY A 369
GLY A 274
GLU A 365
ALA A 373
 None
 0.79A 3fpjB-3sdoA:
undetectable		 3fpjB-3sdoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 GLY A 504
GLY A 482
THR A 377
ALA A 509
 None
 0.85A 3fpjB-3sqlA:
2.0		 3fpjB-3sqlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 340
GLY A 342
GLU A 316
ALA A 185
 None
 0.77A 3fpjB-3ss6A:
undetectable		 3fpjB-3ss6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 GLY A 204
GLY A 208
THR A 254
GLU A 199
 None
 0.85A 3fpjB-3t33A:
undetectable		 3fpjB-3t33A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 GLY A 226
GLY A 285
GLU A 164
ALA A 232
 None
 0.64A 3fpjB-3t33A:
undetectable		 3fpjB-3t33A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 GLN A 831
GLY A 867
GLY A 873
ALA A 822
 None
A1R  A1001 (-2.9A)
None
A1R  A1001 ( 4.6A)
 0.84A 3fpjB-3uelA:
undetectable		 3fpjB-3uelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 289
GLY A 291
THR A 161
ALA A 256
 None
 0.71A 3fpjB-3v39A:
undetectable		 3fpjB-3v39A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLY A 202
GLY A 205
THR A 167
GLU A 197
 None
 0.75A 3fpjB-3wywA:
2.3		 3fpjB-3wywA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 292
GLY A 288
GLU A 312
GLU A 120
 None
 0.79A 3fpjB-3zx1A:
undetectable		 3fpjB-3zx1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLY A1432
THR A1386
GLU A1594
ALA A1445
 None
 0.87A 3fpjB-4bedA:
undetectable		 3fpjB-4bedA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 GLY A  34
GLY A  58
THR A  48
ALA A  13
 None
 0.88A 3fpjB-4bo6A:
7.1		 3fpjB-4bo6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 GLN A 166
GLY A 135
GLU A 106
ALA A 146
 None
 0.75A 3fpjB-4c1nA:
2.0		 3fpjB-4c1nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB
SFN68 FAB

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLN L  89
GLY H  99
GLY H 101
ALA H  97
 None
 0.84A 3fpjB-4d3cL:
undetectable		 3fpjB-4d3cL:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 GLN A 335
GLY A 367
GLY A 373
ALA A 326
 None
APR  A 501 (-2.9A)
None
APR  A 501 ( 4.6A)
 0.79A 3fpjB-4eppA:
undetectable		 3fpjB-4eppA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 GLN A 828
GLY A 864
GLY A 870
ALA A 819
 None
 0.81A 3fpjB-4fc2A:
undetectable		 3fpjB-4fc2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 GLY A 535
GLY A 531
GLU A 460
ALA A 537
 None
None
EDO  A 821 (-2.8A)
None
 0.76A 3fpjB-4fusA:
undetectable		 3fpjB-4fusA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		4 GLY A  49
GLY A  51
GLU A 174
GLU A  10
 GLY  A  49 ( 0.0A)
GLY  A  51 ( 0.0A)
GLU  A 174 ( 0.6A)
GLU  A  10 ( 0.6A)
 0.87A 3fpjB-4g41A:
undetectable		 3fpjB-4g41A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 GLN N  60
GLY N 427
GLY N  45
ALA N 422
 None
 0.86A 3fpjB-4heaN:
undetectable		 3fpjB-4heaN:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hg2 METHYLTRANSFERASE
TYPE 11

(Anaeromyxobacter
dehalogenans) 		PF08241
(Methyltransf_11) 		4 GLN A  49
GLY A  44
GLY A  46
GLU A  88
 None
 0.73A 3fpjB-4hg2A:
11.9		 3fpjB-4hg2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 GLY A 309
GLY A 389
GLU A 316
ALA A  82
 None
 0.81A 3fpjB-4humA:
undetectable		 3fpjB-4humA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		4 GLY A 203
GLY A 194
GLU A 224
ALA A 236
 None
LLP  A 196 ( 4.4A)
None
None
 0.82A 3fpjB-4ixoA:
2.6		 3fpjB-4ixoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 GLN B 246
GLY B  88
GLY B 220
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
 0.82A 3fpjB-4iyoB:
2.4		 3fpjB-4iyoB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLN A 599
GLY A 790
GLY A 787
GLU A 889
 None
 0.80A 3fpjB-4nmeA:
5.8		 3fpjB-4nmeA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 343
GLY A 345
GLU A 319
ALA A 187
 None
 0.83A 3fpjB-4nzsA:
undetectable		 3fpjB-4nzsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oju HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Pseudoflavonifractor
capillosus) 		PF13306
(LRR_5) 		4 GLY A  81
GLY A 103
GLU A  39
ALA A  84
 None
 0.83A 3fpjB-4ojuA:
undetectable		 3fpjB-4ojuA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 GLY A  90
GLY A  92
GLU A 112
GLU A 141
 SAH  A1000 (-3.2A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-2.7A)
SAH  A1000 (-3.3A)
 0.78A 3fpjB-4qppA:
7.6		 3fpjB-4qppA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 GLY A  14
GLY A  16
THR A  23
ALA A 219
 FAD  A 502 (-3.6A)
FAD  A 502 (-4.2A)
None
None
 0.86A 3fpjB-4rslA:
3.3		 3fpjB-4rslA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucw HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Desulfovibrio
fructosivorans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 132
GLY A  77
THR A  80
ALA A 136
 None
 0.86A 3fpjB-4ucwA:
undetectable		 3fpjB-4ucwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		4 GLY A  10
THR A  18
GLU A  33
ALA A 208
 FAD  A 401 (-3.2A)
None
FAD  A 401 (-2.9A)
None
 0.73A 3fpjB-4x9nA:
3.1		 3fpjB-4x9nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 GLY A 248
GLY A 220
GLU A 283
ALA A 288
 None
C5P  A 401 (-3.1A)
None
None
 0.86A 3fpjB-4xsvA:
3.1		 3fpjB-4xsvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLN A 329
GLY A 298
GLY A 295
ALA A 303
 None
None
PYR  A 601 (-3.3A)
None
 0.88A 3fpjB-4yj5A:
2.5		 3fpjB-4yj5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  17
GLY A  20
THR A  26
ALA A 109
 None
 0.85A 3fpjB-4zn6A:
4.3		 3fpjB-4zn6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  12
GLY A  15
THR A  21
ALA A 103
 NAD  A 501 (-3.3A)
NAD  A 501 (-3.4A)
None
NAD  A 501 (-4.4A)
 0.84A 3fpjB-4zqgA:
4.3		 3fpjB-4zqgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		4 GLY A  11
THR A  19
GLU A  34
ALA A 177
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-2.8A)
None
 0.86A 3fpjB-5bukA:
2.5		 3fpjB-5bukA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 GLY A 101
GLY A 103
GLU A 125
ALA A 170
 None
 0.87A 3fpjB-5c1iA:
15.1		 3fpjB-5c1iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 277
GLY A 279
THR A 149
ALA A 244
 None
 0.72A 3fpjB-5cerA:
undetectable		 3fpjB-5cerA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyn LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF02217
(T_Ag_DNA_bind) 		4 GLY A 189
GLY A 191
GLU A 246
ALA A 243
 None
 0.84A 3fpjB-5cynA:
undetectable		 3fpjB-5cynA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 GLN A 318
GLY A 289
GLY A 286
ALA A 436
 PLP  A 601 (-3.4A)
None
None
None
 0.72A 3fpjB-5ddsA:
undetectable		 3fpjB-5ddsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 GLY B 760
GLU B 759
GLU B 782
ALA B 906
 None
 0.82A 3fpjB-5gjeB:
undetectable		 3fpjB-5gjeB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00180
(Iso_dh) 		5 GLN A 134
GLY A  84
GLY A 131
THR A  99
ALA A  87
 None
 1.16A 3fpjB-5j32A:
undetectable		 3fpjB-5j32A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		4 GLN C 374
GLY C  44
THR A 351
GLU A 345
 None
 0.87A 3fpjB-5k1cC:
undetectable		 3fpjB-5k1cC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A   8
GLY A  11
THR A  17
ALA A 100
 None
 0.79A 3fpjB-5ks1A:
4.1		 3fpjB-5ks1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum) 		PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3) 		4 GLN A 477
GLY A 501
GLY A 512
ALA A 489
 None
 0.72A 3fpjB-5lo9A:
undetectable		 3fpjB-5lo9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		4 GLN A 394
GLY A 363
GLY A 370
ALA A 375
 None
 0.68A 3fpjB-5mf1A:
undetectable		 3fpjB-5mf1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLN A 395
GLY A 385
THR A 389
ALA A 380
 None
 0.70A 3fpjB-5nitA:
4.0		 3fpjB-5nitA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLY A  26
THR A  34
GLU A  50
ALA A 288
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-2.7A)
None
 0.75A 3fpjB-5nitA:
4.0		 3fpjB-5nitA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 GLY A 150
THR A 158
GLU A 173
ALA A 327
 FAD  A 701 (-3.2A)
None
FAD  A 701 (-2.9A)
None
 0.73A 3fpjB-5odrA:
5.1		 3fpjB-5odrA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 GLY A   9
GLY A  11
GLU A  33
ALA A  66
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.6A)
 0.77A 3fpjB-5t57A:
6.4		 3fpjB-5t57A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 4 GLY A 601
GLY A 564
THR A 631
ALA A 299
 None
 0.54A 3fpjB-5ta1A:
undetectable		 3fpjB-5ta1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		4 GLY A 186
GLY A 182
THR A 201
ALA A  59
 None
 0.73A 3fpjB-5tsbA:
undetectable		 3fpjB-5tsbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B 295
GLY B 290
GLU B 298
ALA B 285
 None
 0.87A 3fpjB-5txrB:
2.3		 3fpjB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 GLN A 253
GLY A 187
GLY A 165
ALA A 190
 None
 0.77A 3fpjB-5vawA:
undetectable		 3fpjB-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S5,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 GLY e 244
GLY e 246
THR e 222
ALA e 242
 None
None
None
U  a   6 ( 3.2A)
 0.82A 3fpjB-5x8re:
undetectable		 3fpjB-5x8re:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLN A 382
GLY A 466
GLU A 469
ALA A 389
 None
 0.87A 3fpjB-6cczA:
3.9		 3fpjB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLY X 475
GLY X 445
GLU X 299
ALA X 478
 BF8  X 702 ( 4.1A)
BF8  X 702 (-4.2A)
None
None
 0.85A 3fpjB-6elqX:
3.9		 3fpjB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY A 308
GLY A 311
GLU A 711
ALA A 316
 None
 0.87A 3fpjB-6fuzA:
undetectable		 3fpjB-6fuzA:
undetectable