SIMILAR PATTERNS OF AMINO ACIDS FOR 3FPJ_B_SAMB301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a33 PEPTIDYLPROLYL
ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		5 PHE A 124
ILE A 125
VAL A 109
GLU A 105
VAL A 150
 None
 1.18A 3fpjB-1a33A:
undetectable		 3fpjB-1a33A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cqi PROTEIN
(SUCCINYL-COA
SYNTHETASE BETA
CHAIN)

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		5 ILE B 332
VAL B 347
ILE B 318
LEU B 327
VAL B 298
 None
 1.14A 3fpjB-1cqiB:
4.1		 3fpjB-1cqiB:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		5 ILE A 133
ILE A 171
GLU A 159
LEU A 153
VAL A 141
 None
 1.22A 3fpjB-1d2rA:
2.3		 3fpjB-1d2rA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		5 ILE A 302
VAL A  28
GLU A  23
LEU A 297
VAL A  93
 None
 1.19A 3fpjB-1dkrA:
3.8		 3fpjB-1dkrA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu3 ENDOGLUCANASE C

(Cellulomonas
fimi) 		PF02018
(CBM_4_9) 		5 TYR A 112
PHE A 106
LEU A  77
ARG A 100
VAL A 102
 None
 1.24A 3fpjB-1gu3A:
undetectable		 3fpjB-1gu3A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		5 ILE A 201
VAL A 243
ILE A 196
VAL A 271
ARG A 217
 None
 1.25A 3fpjB-1i60A:
undetectable		 3fpjB-1i60A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhz PURINE NUCLEOTIDE
SYNTHESIS REPRESSOR

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 TYR A 126
ILE A 140
ILE A 309
LEU A 120
VAL A 116
 None
 1.24A 3fpjB-1jhzA:
3.8		 3fpjB-1jhzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		5 PHE A 312
ILE A 311
ILE A 188
VAL A  99
ARG A 151
 None
 1.15A 3fpjB-1n7uA:
undetectable		 3fpjB-1n7uA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqn SPLICEOSOMAL U5
SNRNP-SPECIFIC 15
KDA PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		5 ILE A  28
VAL A  26
ILE A  58
ILE A 116
VAL A  61
 None
 1.16A 3fpjB-1pqnA:
undetectable		 3fpjB-1pqnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t47 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Streptomyces
avermitilis) 		PF00903
(Glyoxalase) 		5 MET A 285
TYR A  39
ILE A 271
ILE A 351
ILE A 335
 None
 1.19A 3fpjB-1t47A:
undetectable		 3fpjB-1t47A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 232
ILE A 215
ILE A 248
LEU A 254
VAL A 229
 None
 1.20A 3fpjB-1vecA:
4.2		 3fpjB-1vecA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE B 146
ILE B 168
ILE B  80
LEU B 132
VAL B 238
 None
 1.09A 3fpjB-1w85B:
2.8		 3fpjB-1w85B:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 ILE A 343
ILE A 313
LEU A 330
VAL A 369
ARG A 345
 None
 1.19A 3fpjB-1yr2A:
undetectable		 3fpjB-1yr2A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgd CHALCONE REDUCTASE

(Medicago sativa) 		PF00248
(Aldo_ket_red) 		5 TYR A  58
ILE A 119
VAL A 165
ILE A 163
VAL A 147
 NAP  A 755 (-3.9A)
None
None
None
None
 1.24A 3fpjB-1zgdA:
undetectable		 3fpjB-1zgdA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy1 PEPTIDE DEFORMYLASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF01327
(Pep_deformylase) 		5 ILE A 150
GLU A 154
ILE A  62
LEU A  89
ARG A  84
 None
ZN  A 198 ( 4.8A)
None
None
None
 1.14A 3fpjB-1zy1A:
undetectable		 3fpjB-1zy1A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8t THYMIDINE KINASE

(Ureaplasma
parvum) 		PF00265
(TK) 		5 PHE A 117
VAL A 118
ILE A  95
LEU A  44
VAL A  41
 None
 1.25A 3fpjB-2b8tA:
3.1		 3fpjB-2b8tA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 544
VAL A 542
ILE A 493
ILE A 555
VAL A 496
 None
 1.20A 3fpjB-2db3A:
3.1		 3fpjB-2db3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 544
VAL A 542
ILE A 555
VAL A 496
ARG A 523
 None
 1.07A 3fpjB-2db3A:
3.1		 3fpjB-2db3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpq BOTULINUM NEUROTOXIN
D LIGHT CHAIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		5 ILE A 158
VAL A 156
ILE A 191
ILE A 136
VAL A 194
 None
 1.11A 3fpjB-2fpqA:
undetectable		 3fpjB-2fpqA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		5 PHE A 424
ILE A 426
VAL A 348
ILE A 344
VAL A 278
 None
 1.17A 3fpjB-2ftwA:
undetectable		 3fpjB-2ftwA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		5 ILE A 117
VAL A 239
ILE A 245
VAL A 129
ARG A 119
 None
 1.20A 3fpjB-2i6dA:
undetectable		 3fpjB-2i6dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6j SULFOLOBUS
SOLFATARICUS PROTEIN
TYROSINE PHOSPHATASE

(Sulfolobus
solfataricus) 		PF00102
(Y_phosphatase) 		5 VAL A  72
ILE A 106
ILE A  65
LEU A  79
VAL A 146
 None
 1.23A 3fpjB-2i6jA:
undetectable		 3fpjB-2i6jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivx CYCLIN-T2

(Homo sapiens) 		PF00134
(Cyclin_N) 		5 MET A 139
ILE A  44
ILE A  82
LEU A  89
VAL A  53
 None
 0.88A 3fpjB-2ivxA:
undetectable		 3fpjB-2ivxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lm5 CALCIUM AND
INTEGRIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 PHE A 173
ILE A 168
VAL A 176
ILE A 156
LEU A 131
 None
 1.15A 3fpjB-2lm5A:
undetectable		 3fpjB-2lm5A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 156
VAL A 207
ILE A   6
LEU A 159
VAL A  35
 ILE  A 156 ( 0.7A)
VAL  A 207 ( 0.6A)
ILE  A   6 ( 0.7A)
LEU  A 159 ( 0.6A)
VAL  A  35 ( 0.6A)
 1.00A 3fpjB-2nvvA:
undetectable		 3fpjB-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		5 ILE A 426
VAL A 603
ILE A 609
VAL A 437
ARG A 480
 None
 1.20A 3fpjB-2o1xA:
3.0		 3fpjB-2o1xA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 MET A 273
ILE A 296
VAL A 184
VAL A 173
ARG A 231
 LBV  A 400 ( 4.6A)
None
None
None
None
 1.23A 3fpjB-2oolA:
undetectable		 3fpjB-2oolA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p38 PROTEIN INVOLVED IN
RIBOSOMAL BIOGENESIS

(Pyrococcus
abyssi) 		PF03657
(UPF0113) 		5 PHE A 108
ILE A 140
ILE A  99
GLU A 121
ILE A 122
 None
 1.22A 3fpjB-2p38A:
undetectable		 3fpjB-2p38A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prv UNCHARACTERIZED
PROTEIN YOBK

(Bacillus
subtilis) 		PF14567
(SUKH_5) 		5 PHE A  56
ILE A 137
VAL A  58
ILE A  18
VAL A   6
 None
None
EDO  A 157 (-4.2A)
None
None
 1.18A 3fpjB-2prvA:
undetectable		 3fpjB-2prvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Methanosarcina
mazei) 		PF04406
(TP6A_N) 		5 TYR A 139
ILE A 181
ILE A 157
GLU A 189
ARG A 236
 None
 1.14A 3fpjB-2q2eA:
undetectable		 3fpjB-2q2eA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvx 4-CHLOROBENZOATE COA
LIGASE

(Alcaligenes sp.
AL3007) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 ILE X 433
VAL X 432
GLU X 429
LEU X 494
VAL X 502
 None
 1.20A 3fpjB-2qvxX:
4.5		 3fpjB-2qvxX:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		5 ILE A 326
VAL A 376
LEU A 309
VAL A 347
ARG A 329
 None
 1.04A 3fpjB-2v1uA:
undetectable		 3fpjB-2v1uA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ILE A 618
VAL A 737
ILE A 733
GLU A 730
VAL A 655
 None
 1.03A 3fpjB-2vwkA:
undetectable		 3fpjB-2vwkA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 MET A   3
ILE A   8
LEU A  38
VAL A  53
ARG A  30
 None
 1.20A 3fpjB-2xryA:
undetectable		 3fpjB-2xryA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 272
VAL A 306
ILE A 302
LEU A 267
VAL A 372
 None
 1.10A 3fpjB-3a5rA:
undetectable		 3fpjB-3a5rA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpv TRANSCRIPTIONAL
REGULATOR

(Methanothermobacter
thermautotrophicus) 		PF01047
(MarR) 		5 PHE A  21
ILE A  22
ILE A  14
VAL A  36
ARG A 110
 None
 1.08A 3fpjB-3bpvA:
undetectable		 3fpjB-3bpvA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d36 SPORULATION KINASE B

(Geobacillus
stearothermophilus) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 ILE A 280
ILE A 410
ILE A 388
LEU A 319
VAL A 337
 None
 1.02A 3fpjB-3d36A:
undetectable		 3fpjB-3d36A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d46 PUTATIVE GALACTONATE
DEHYDRATASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 334
VAL A 109
GLU A 105
ILE A 104
ARG A  79
 None
 1.23A 3fpjB-3d46A:
undetectable		 3fpjB-3d46A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Clostridioides
difficile) 		PF01380
(SIS) 		5 ILE A 274
VAL A 270
ILE A 213
ILE A 246
VAL A 284
 None
 1.09A 3fpjB-3g68A:
undetectable		 3fpjB-3g68A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grz RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE

(Lactobacillus
delbrueckii) 		PF06325
(PrmA) 		5 ILE A 170
ILE A 189
ILE A 122
LEU A 165
VAL A 246
 None
 1.04A 3fpjB-3grzA:
14.3		 3fpjB-3grzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ILE A 485
VAL A 475
ILE A 378
LEU A 523
ARG A 522
 None
None
None
NAD  A 608 ( 4.4A)
None
 1.25A 3fpjB-3gvpA:
8.4		 3fpjB-3gvpA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4y PUTATIVE CHEMOTAXIS
PROTEIN

(Desulfovibrio
vulgaris) 		PF13690
(CheX) 		5 MET A 109
ILE A  98
ILE A  13
VAL A 150
ARG A 103
 None
 1.00A 3fpjB-3h4yA:
undetectable		 3fpjB-3h4yA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 ILE B  80
LEU B  87
ARG B  71
VAL B  70
ARG B  86
 None
 1.24A 3fpjB-3hkzB:
undetectable		 3fpjB-3hkzB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irz URO-ADHERENCE FACTOR
A

(Staphylococcus
saprophyticus) 		PF17210
(SdrD_B) 		5 TYR A 556
ILE A 647
VAL A 597
ILE A 625
VAL A 580
 None
 1.24A 3fpjB-3irzA:
undetectable		 3fpjB-3irzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 VAL A   6
ILE A 116
ILE A 152
LEU A 102
VAL A 327
 None
 1.11A 3fpjB-3js6A:
undetectable		 3fpjB-3js6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Escherichia
coli) 		PF01135
(PCMT) 		5 ILE A 167
ILE A 146
GLU A  81
ILE A  82
ARG A 184
 None
None
SAH  A 300 ( 4.7A)
SAH  A 300 ( 4.8A)
None
 1.25A 3fpjB-3lbfA:
11.0		 3fpjB-3lbfA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		5 ILE A 191
ILE A 160
LEU A 197
VAL A 201
ARG A 196
 None
 1.20A 3fpjB-3lpdA:
2.1		 3fpjB-3lpdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		5 TYR A 146
ILE A 115
ILE A 200
LEU A 142
VAL A 117
 None
 1.24A 3fpjB-3mbfA:
undetectable		 3fpjB-3mbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 TYR A 250
ILE A  80
ILE A  42
ARG A  75
VAL A  76
 None
 1.19A 3fpjB-3mmwA:
undetectable		 3fpjB-3mmwA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 5 ILE A 103
ILE A 124
GLU A 226
ILE A 227
VAL A 246
 FAD  A 601 (-4.6A)
None
None
None
None
 1.23A 3fpjB-3nlcA:
3.4		 3fpjB-3nlcA:
19.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		8 MET A  78
ILE A 129
ILE A 154
GLU A 155
ILE A 158
LEU A 197
ARG A 203
VAL A 204
 None
None
None
None
None
3O3  A   1 (-4.2A)
None
None
 0.93A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		11 TYR A 107
PHE A 128
ILE A 129
VAL A 152
ILE A 154
GLU A 155
ILE A 158
LEU A 197
ARG A 203
VAL A 204
ARG A 221
 3O3  A   1 (-3.8A)
BR  A 298 ( 4.8A)
None
None
None
None
None
3O3  A   1 (-4.2A)
None
None
3O3  A   1 (-4.0A)
 0.44A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6c PYRIDOXINE
5'-PHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		PF03740
(PdxJ) 		5 ILE A 226
VAL A 220
GLU A 188
LEU A 194
VAL A 206
 None
 1.19A 3fpjB-3o6cA:
undetectable		 3fpjB-3o6cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 TYR A 102
PHE A 124
VAL A 131
ILE A 261
ILE A 288
 None
 1.25A 3fpjB-3oksA:
undetectable		 3fpjB-3oksA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ILE A 316
VAL A 311
ILE A 336
ILE A 331
LEU A 348
 None
 1.22A 3fpjB-3qn3A:
undetectable		 3fpjB-3qn3A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruc WBGU

(Plesiomonas
shigelloides) 		PF01370
(Epimerase) 		5 ILE A  28
VAL A 242
ILE A 247
LEU A  33
ARG A 200
 NAD  A 343 (-3.8A)
None
None
None
None
 1.17A 3fpjB-3rucA:
6.5		 3fpjB-3rucA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr4 INORGANIC
PYROPHOSPHATASE

(Coxiella
burnetii) 		PF00719
(Pyrophosphatase) 		5 VAL A  78
GLU A  19
ILE A  20
LEU A  71
VAL A  86
 None
 1.13A 3fpjB-3tr4A:
undetectable		 3fpjB-3tr4A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuo NTNHA

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 PHE A 203
ILE A 171
ILE A 102
ILE A 227
VAL A  35
 None
 1.12A 3fpjB-3vuoA:
2.6		 3fpjB-3vuoA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		5 PHE A 102
VAL A  77
ILE A   7
LEU A  88
VAL A  97
 None
 1.25A 3fpjB-3wwpA:
3.2		 3fpjB-3wwpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zf8 MANNAN POLYMERASE
COMPLEXES SUBUNIT
MNN9

(Saccharomyces
cerevisiae) 		PF03452
(Anp1) 		5 ILE A 257
VAL A 343
ILE A 247
LEU A 382
VAL A 336
 None
 1.23A 3fpjB-3zf8A:
undetectable		 3fpjB-3zf8A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 MET A 133
ILE A 169
ILE A 215
ILE A 158
VAL A 196
 None
 1.08A 3fpjB-3zh4A:
undetectable		 3fpjB-3zh4A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3q ALANINE RACEMASE 1

(Staphylococcus
aureus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 PHE A 166
ILE A 130
VAL A 165
LEU A 103
VAL A 150
 None
 1.19A 3fpjB-4a3qA:
undetectable		 3fpjB-4a3qA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		5 VAL A 737
GLU A 308
ILE A 310
VAL A 527
ARG A 287
 None
 1.23A 3fpjB-4bq4A:
undetectable		 3fpjB-4bq4A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c89 ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		5 PHE A 156
ILE A 155
LEU A 101
ARG A  76
VAL A  87
 None
 1.17A 3fpjB-4c89A:
2.7		 3fpjB-4c89A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di5 5-EPI-ARISTOLOCHENE
SYNTHASE

(Nicotiana
tabacum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 TYR A  81
PHE A 228
ILE A 548
ILE A 546
LEU A 235
 None
 1.22A 3fpjB-4di5A:
undetectable		 3fpjB-4di5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		5 TYR A 324
ILE A 232
ILE A 189
ILE A 155
LEU A 192
 None
None
None
None
GOL  A 500 (-4.9A)
 1.11A 3fpjB-4dnhA:
undetectable		 3fpjB-4dnhA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		5 ILE A 434
ILE A 421
ILE A 423
LEU A 459
VAL A 436
 None
 1.21A 3fpjB-4gz8A:
undetectable		 3fpjB-4gz8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpr THIOREDOXIN
REDUCTASE 1,
CYTOPLASMIC

(Rattus
norvegicus) 		no annotation 5 MET E 232
PHE E 479
ILE E 478
ILE E 492
LEU E 441
 None
 1.25A 3fpjB-4kprE:
3.6		 3fpjB-4kprE:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 PHE A1234
ILE A1237
VAL A1233
LEU A1242
VAL A1174
 None
 1.20A 3fpjB-4ll6A:
undetectable		 3fpjB-4ll6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		5 PHE A 231
ILE A 232
VAL A 210
ILE A 145
VAL A 240
 None
 1.15A 3fpjB-4mp3A:
3.1		 3fpjB-4mp3A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtn TRANSCRIPTION
TERMINATION FACTOR
NUSA

(Planctopirus
limnophila) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5)
PF14520
(HHH_5) 		5 ILE A 195
ILE A 185
GLU A 187
ILE A 192
VAL A 208
 None
 1.24A 3fpjB-4mtnA:
undetectable		 3fpjB-4mtnA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ILE A 200
VAL A 201
GLU A 175
ILE A  20
LEU A 179
 None
None
AMP  A 501 (-3.6A)
None
None
 1.06A 3fpjB-4o6rA:
5.4		 3fpjB-4o6rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 ILE A  50
VAL A  36
ILE A  38
GLU A  46
VAL A  58
 None
 1.20A 3fpjB-4pd3A:
3.7		 3fpjB-4pd3A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4phc HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 PHE A 390
ILE A 389
ILE A 198
ILE A  81
VAL A 357
 None
 1.18A 3fpjB-4phcA:
undetectable		 3fpjB-4phcA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwv P450 MONOOXYGENASE

(Streptomyces
sp. Acta 2897) 		PF00067
(p450) 		5 TYR A 415
GLU A 366
ILE A 126
LEU A 133
VAL A 260
 None
HEM  A 501 ( 4.9A)
None
None
None
 1.22A 3fpjB-4pwvA:
undetectable		 3fpjB-4pwvA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		5 ILE B 418
VAL B 362
GLU B 359
LEU B 423
VAL B 106
 None
 1.21A 3fpjB-4um8B:
undetectable		 3fpjB-4um8B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzr PUTATIVE
UNCHARACTERIZED
PROTEIN PH1500

(Pyrococcus
horikoshii) 		PF02933
(CDC48_2) 		5 ILE A 109
ILE A 101
ILE A  88
LEU A  93
VAL A 135
 None
 1.01A 3fpjB-4uzrA:
undetectable		 3fpjB-4uzrA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbg ACETYLTRANSFERASE

(Brucella
abortus) 		PF13527
(Acetyltransf_9) 		5 ILE A  14
VAL A  50
ILE A  61
ILE A  92
VAL A  36
 None
None
None
ACO  A 201 (-4.3A)
None
 1.24A 3fpjB-4zbgA:
undetectable		 3fpjB-4zbgA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		5 ILE A 158
VAL A 156
ILE A 191
ILE A 136
VAL A 194
 None
 1.14A 3fpjB-5bqnA:
undetectable		 3fpjB-5bqnA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 PHE A  76
ILE A  75
GLU A 122
LEU A 138
VAL A 134
 None
None
MG  A 501 ( 2.6A)
None
None
 1.20A 3fpjB-5co8A:
3.7		 3fpjB-5co8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 PHE B  57
ILE B  56
VAL B  58
ILE B 108
ARG B  52
 None
 1.20A 3fpjB-5cwwB:
2.6		 3fpjB-5cwwB:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		5 TYR A 717
PHE A 704
ILE A 970
VAL A 973
ILE A 650
 None
 1.25A 3fpjB-5dztA:
undetectable		 3fpjB-5dztA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Vibrio cholerae) 		PF01182
(Glucosamine_iso) 		5 ILE A 237
VAL A 203
GLU A 241
VAL A 216
ARG A   2
 None
 1.14A 3fpjB-5hj5A:
2.3		 3fpjB-5hj5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuw ALDEHYDE
DEHYDROGENASE FAMILY
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 ILE A 323
ILE A 314
LEU A 308
ARG A 366
VAL A 368
 None
 1.07A 3fpjB-5iuwA:
undetectable		 3fpjB-5iuwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb1 MAJOR CAPSID PROTEIN
L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		5 PHE A 377
ILE A 376
VAL A 103
ILE A 159
LEU A 373
 None
 1.23A 3fpjB-5jb1A:
undetectable		 3fpjB-5jb1A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jgy ALDOSE REDUCTASE,
AKR4C13

(Zea mays) 		PF00248
(Aldo_ket_red) 		5 TYR A  59
ILE A 119
VAL A 164
ILE A 162
VAL A 146
 6KB  A 401 ( 4.6A)
None
None
None
None
 1.24A 3fpjB-5jgyA:
undetectable		 3fpjB-5jgyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		5 PHE A 371
ILE A 372
ILE A 524
ARG A 491
VAL A 488
 None
 0.90A 3fpjB-5kkpA:
undetectable		 3fpjB-5kkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		5 PHE A 371
ILE A 372
VAL A 120
ARG A 491
VAL A 488
 None
 1.21A 3fpjB-5kkpA:
undetectable		 3fpjB-5kkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg3 PROTEIN TRANSLOCASE
SUBUNIT SECF

(Escherichia
coli) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 TYR F 263
ILE F 283
VAL F 181
ILE F 183
ILE F 187
 None
 1.14A 3fpjB-5mg3F:
undetectable		 3fpjB-5mg3F:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n22 XECO2

(Xenopus laevis) 		PF13880
(Acetyltransf_13) 		5 ILE A 587
VAL A 581
ILE A 528
LEU A 591
VAL A 554
 None
 1.22A 3fpjB-5n22A:
undetectable		 3fpjB-5n22A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njl CELL SURFACE PROTEIN
(PUTATIVE S-LAYER
PROTEIN)

(Clostridioides
difficile) 		no annotation 5 ILE A  83
ILE A  68
ILE A  79
LEU A  89
VAL A  44
 None
None
SO4  A 410 (-3.6A)
None
None
 1.18A 3fpjB-5njlA:
undetectable		 3fpjB-5njlA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 ILE A 262
GLU A 256
LEU A 253
VAL A 306
ARG A 267
 None
None
None
None
PG4  A 403 ( 3.6A)
 0.90A 3fpjB-5o25A:
3.1		 3fpjB-5o25A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oon UNDECAPRENYL-DIPHOSP
HATASE

(Escherichia
coli) 		no annotation 5 ILE A  12
VAL A  15
ILE A  52
ILE A 232
LEU A   7
 None
 1.24A 3fpjB-5oonA:
undetectable		 3fpjB-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 ILE A 168
ILE A 173
ILE A 133
LEU A 232
VAL A 155
 None
 1.00A 3fpjB-5turA:
undetectable		 3fpjB-5turA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 283
VAL A 317
ILE A 313
LEU A 278
VAL A 383
 None
 0.99A 3fpjB-5ucoA:
undetectable		 3fpjB-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S7, PUTATIVE

(Trichomonas
vaginalis) 		PF01251
(Ribosomal_S7e) 		5 ILE H  24
VAL H   5
ILE H  69
GLU H  62
VAL H  42
 None
 1.16A 3fpjB-5xyiH:
undetectable		 3fpjB-5xyiH:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 5 ILE A  95
ILE A 288
ILE A 300
LEU A  98
VAL A 184
 None
 0.95A 3fpjB-6ayvA:
undetectable		 3fpjB-6ayvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 MET A 125
ILE A 192
GLU A 145
LEU A 142
VAL A  84
 None
None
LLP  A 199 ( 3.7A)
None
None
 1.23A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 MET A 125
ILE A 192
VAL A 193
GLU A 145
LEU A 142
 None
None
None
LLP  A 199 ( 3.7A)
None
 1.22A 3fpjB-6cjbA:
4.1		 3fpjB-6cjbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gmb HYDROXYACID OXIDASE
1

(Homo sapiens) 		no annotation 5 ILE A 317
VAL A  77
ILE A  75
VAL A 332
ARG A 315
 None
None
None
None
FMN  A 506 ( 3.8A)
 1.11A 3fpjB-6gmbA:
undetectable		 3fpjB-6gmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 GLY A  53
GLY A  48
THR A  43
ALA A  57
 None
 0.82A 3fpjB-1fpsA:
undetectable		 3fpjB-1fpsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4v HISTIDYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 GLY B 304
GLY B 302
THR B 267
ALA B 143
 None
 0.75A 3fpjB-1h4vB:
undetectable		 3fpjB-1h4vB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 GLY A  42
GLY A  87
THR A  57
ALA A  45
 None
 0.87A 3fpjB-1idmA:
undetectable		 3fpjB-1idmA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 GLY A  69
GLY A  65
THR A  60
ALA A  71
 None
 0.78A 3fpjB-1ik6A:
2.9		 3fpjB-1ik6A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A  98
GLY A 100
THR A 104
GLU A 121
 None
 0.74A 3fpjB-1inlA:
9.7		 3fpjB-1inlA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 GLY A  57
THR A 158
GLU A  60
GLU A  66
 None
 0.72A 3fpjB-1ir6A:
3.6		 3fpjB-1ir6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 GLY A 480
GLY A 450
GLU A 304
ALA A 483
 WCC  A 800 ( 4.4A)
WCC  A 800 (-4.1A)
None
None
 0.83A 3fpjB-1jqkA:
2.4		 3fpjB-1jqkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		4 GLY A 208
GLY A  97
GLU A  40
ALA A  44
 None
 0.87A 3fpjB-1oa4A:
undetectable		 3fpjB-1oa4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Wolinella
succinogenes) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 GLY A 421
GLY A 417
GLU A 426
ALA A  23
 None
 0.87A 3fpjB-1qlbA:
undetectable		 3fpjB-1qlbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r0l 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Zymomonas
mobilis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  11
GLY A  14
THR A  20
ALA A 100
 NDP  A 400 (-3.1A)
NDP  A 400 (-3.8A)
None
None
 0.86A 3fpjB-1r0lA:
4.7		 3fpjB-1r0lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0m PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 GLY A 191
GLY A 189
THR A 297
ALA A 307
 None
 0.86A 3fpjB-1u0mA:
undetectable		 3fpjB-1u0mA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 GLY A 148
GLY A 152
GLU A 143
ALA A 124
 None
 0.84A 3fpjB-1xw8A:
undetectable		 3fpjB-1xw8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 4 GLY A 182
GLU A 185
GLU A  47
ALA A  41
 None
 0.85A 3fpjB-1y8aA:
2.1		 3fpjB-1y8aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		4 GLY A 226
GLY A 223
GLU A 231
GLU A  99
 None
 0.88A 3fpjB-2bwpA:
2.3		 3fpjB-2bwpA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdu NADPH OXIDASE

(Lactobacillus
sanfranciscensis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 GLY A  12
GLY A 307
THR A  19
GLU A  32
 None
None
None
FAD  A 500 (-2.6A)
 0.82A 3fpjB-2cduA:
3.8		 3fpjB-2cduA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csg PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07350
(DUF1479) 		4 GLY A 274
GLY A 272
GLU A 136
ALA A 348
 None
 0.66A 3fpjB-2csgA:
undetectable		 3fpjB-2csgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		5 GLN X  27
GLY X 107
GLY X 105
THR X 179
GLU X 160
 None
 1.14A 3fpjB-2dchX:
undetectable		 3fpjB-2dchX:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 GLY A  18
GLY A  12
GLU A 201
ALA A  22
 None
CO  A1001 (-3.6A)
None
None
 0.88A 3fpjB-2ehdA:
7.3		 3fpjB-2ehdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 195
THR A 165
GLU A 156
ALA A 149
 None
 0.81A 3fpjB-2gp6A:
undetectable		 3fpjB-2gp6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 GLY A 177
GLY A 175
THR A 124
ALA A 179
 None
 0.87A 3fpjB-2gr9A:
5.6		 3fpjB-2gr9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		4 GLY A 305
GLY A 303
GLU A 341
ALA A 327
 None
FMN  A1401 (-4.1A)
None
None
 0.79A 3fpjB-2h8xA:
undetectable		 3fpjB-2h8xA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4n PROLINE-TRNA LIGASE

(Rhodopseudomonas
palustris) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		4 GLY A 217
THR A 278
GLU A 218
ALA A 214
 None
 0.78A 3fpjB-2i4nA:
undetectable		 3fpjB-2i4nA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iya OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 GLY A 407
GLY A 236
THR A 233
ALA A 411
 None
 0.81A 3fpjB-2iyaA:
4.7		 3fpjB-2iyaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liw CURA

(Lyngbya
majuscula) 		PF00550
(PP-binding) 		4 GLY A1992
THR A1998
GLU A1975
ALA A1968
 None
 0.85A 3fpjB-2liwA:
undetectable		 3fpjB-2liwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ml1 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6

(Azotobacter
vinelandii) 		PF00353
(HemolysinCabind) 		4 GLY A  40
GLY A  21
GLU A  61
ALA A  58
 CA  A 203 ( 4.1A)
CA  A 201 (-4.7A)
None
None
 0.87A 3fpjB-2ml1A:
undetectable		 3fpjB-2ml1A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 130
GLY A 133
GLU A 332
ALA A 336
 None
 0.87A 3fpjB-2pozA:
undetectable		 3fpjB-2pozA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 GLY A  11
THR A  19
GLU A  34
ALA A 203
 FAD  A 401 ( 3.3A)
None
FAD  A 401 ( 2.8A)
None
 0.77A 3fpjB-2q6uA:
4.6		 3fpjB-2q6uA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE

(Deinococcus
radiodurans) 		PF07992
(Pyr_redox_2) 		4 GLY A  20
GLY A 300
THR A  27
GLU A  38
 None
None
None
FAD  A 348 (-2.7A)
 0.86A 3fpjB-2q7vA:
4.0		 3fpjB-2q7vA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		4 GLY A 171
THR A 149
GLU A 179
ALA A 174
 None
 0.72A 3fpjB-2we8A:
7.2		 3fpjB-2we8A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0e UDP-GLUCOSE
DEHYDROGENASE

(Burkholderia
cepacia) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A   7
GLY A   9
THR A  15
ALA A  83
 None
 0.78A 3fpjB-2y0eA:
8.4		 3fpjB-2y0eA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 GLY A 219
THR A 227
GLU A 243
ALA A 299
 None
 0.70A 3fpjB-2yfqA:
4.8		 3fpjB-2yfqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c24 PUTATIVE
OXIDOREDUCTASE

(Jannaschia sp.
CCS1) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 GLY A  17
GLY A  19
GLU A  41
ALA A  73
 None
 0.74A 3fpjB-3c24A:
5.5		 3fpjB-3c24A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 4 GLY B 113
GLY B 109
GLU B 118
ALA B 148
 None
 0.83A 3fpjB-3c6qB:
undetectable		 3fpjB-3c6qB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 GLN X 185
GLY X 181
GLU X  42
ALA X 144
 None
 0.78A 3fpjB-3e13X:
undetectable		 3fpjB-3e13X:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e73 LANC-LIKE PROTEIN 1

(Homo sapiens) 		PF05147
(LANC_like) 		4 GLY A 216
GLY A 278
GLU A 150
ALA A 222
 None
 0.66A 3fpjB-3e73A:
undetectable		 3fpjB-3e73A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h41 NLP/P60 FAMILY
PROTEIN

(Bacillus cereus) 		PF00877
(NLPC_P60) 		4 GLY A 285
GLY A 287
GLU A 323
ALA A 326
 None
PG4  A   5 ( 4.4A)
None
None
 0.82A 3fpjB-3h41A:
undetectable		 3fpjB-3h41A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLY A   9
THR A   6
GLU A  77
ALA A 104
 None
 0.81A 3fpjB-3h4iA:
4.4		 3fpjB-3h4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		4 GLY A  97
GLY A 125
GLU A  42
ALA A 104
 None
 0.85A 3fpjB-3hzuA:
undetectable		 3fpjB-3hzuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLY A  49
THR A  53
GLU A  70
 SAM  A 200 (-3.3A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.4A)
SAM  A 200 (-2.7A)
 0.60A 3fpjB-3ihtA:
9.0		 3fpjB-3ihtA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 GLN X 253
GLY X 207
GLY X 219
ALA X 191
 None
 0.69A 3fpjB-3n5nX:
undetectable		 3fpjB-3n5nX:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		7 GLN A  81
GLY A 130
GLY A 132
THR A 137
GLU A 153
GLU A 181
ALA A 195
 3O3  A   1 ( 4.8A)
None
None
BR  A 298 (-4.0A)
None
None
3O3  A   1 (-3.5A)
 0.30A 3fpjB-3o31A:
42.2		 3fpjB-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 GLY A 163
GLY A 118
THR A  22
ALA A  27
 None
ATP  A 763 (-2.9A)
None
None
 0.78A 3fpjB-3o8lA:
2.0		 3fpjB-3o8lA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt5 NANS (YJHS), A
9-O-ACETYL
N-ACETYLNEURAMINIC
ACID ESTERASE

(Escherichia
coli) 		PF03629
(SASA) 		5 GLN A 260
GLY A 266
GLU A 273
GLU A  26
ALA A 306
 None
 1.38A 3fpjB-3pt5A:
2.1		 3fpjB-3pt5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9o EXOTOXIN A

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly)
PF09101
(Exotox-A_bind)
PF09102
(Exotox-A_target) 		4 GLY A  40
GLY A 120
GLU A 237
ALA A 188
 None
 0.81A 3fpjB-3q9oA:
undetectable		 3fpjB-3q9oA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdo NITRILOTRIACETATE
MONOOXYGENASE

(Burkholderia
pseudomallei) 		PF00296
(Bac_luciferase) 		4 GLY A 369
GLY A 274
GLU A 365
ALA A 373
 None
 0.79A 3fpjB-3sdoA:
undetectable		 3fpjB-3sdoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp. PCC 7002) 		PF00933
(Glyco_hydro_3) 		4 GLY A 504
GLY A 482
THR A 377
ALA A 509
 None
 0.85A 3fpjB-3sqlA:
2.0		 3fpjB-3sqlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss6 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 340
GLY A 342
GLU A 316
ALA A 185
 None
 0.77A 3fpjB-3ss6A:
undetectable		 3fpjB-3ss6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 GLY A 204
GLY A 208
THR A 254
GLU A 199
 None
 0.85A 3fpjB-3t33A:
undetectable		 3fpjB-3t33A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t33 G PROTEIN COUPLED
RECEPTOR

(Arabidopsis
thaliana) 		PF05147
(LANC_like) 		4 GLY A 226
GLY A 285
GLU A 164
ALA A 232
 None
 0.64A 3fpjB-3t33A:
undetectable		 3fpjB-3t33A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 GLN A 831
GLY A 867
GLY A 873
ALA A 822
 None
A1R  A1001 (-2.9A)
None
A1R  A1001 ( 4.6A)
 0.84A 3fpjB-3uelA:
undetectable		 3fpjB-3uelA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v39 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 289
GLY A 291
THR A 161
ALA A 256
 None
 0.71A 3fpjB-3v39A:
undetectable		 3fpjB-3v39A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 GLY A 202
GLY A 205
THR A 167
GLU A 197
 None
 0.75A 3fpjB-3wywA:
2.3		 3fpjB-3wywA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx1 OXIDOREDUCTASE,
PUTATIVE

(Campylobacter
jejuni) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A 292
GLY A 288
GLU A 312
GLU A 120
 None
 0.79A 3fpjB-3zx1A:
undetectable		 3fpjB-3zx1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 GLY A1432
THR A1386
GLU A1594
ALA A1445
 None
 0.87A 3fpjB-4bedA:
undetectable		 3fpjB-4bedA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bo6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		4 GLY A  34
GLY A  58
THR A  48
ALA A  13
 None
 0.88A 3fpjB-4bo6A:
7.1		 3fpjB-4bo6A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CARBON MONOXIDE
DEHYDROGENASE
CORRINOID/IRON-SULFU
R PROTEIN, GAMMA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD)
PF04060
(FeS) 		4 GLN A 166
GLY A 135
GLU A 106
ALA A 146
 None
 0.75A 3fpjB-4c1nA:
2.0		 3fpjB-4c1nA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3c SFN68 FAB
SFN68 FAB

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 GLN L  89
GLY H  99
GLY H 101
ALA H  97
 None
 0.84A 3fpjB-4d3cL:
undetectable		 3fpjB-4d3cL:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 GLN A 335
GLY A 367
GLY A 373
ALA A 326
 None
APR  A 501 (-2.9A)
None
APR  A 501 ( 4.6A)
 0.79A 3fpjB-4eppA:
undetectable		 3fpjB-4eppA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 GLN A 828
GLY A 864
GLY A 870
ALA A 819
 None
 0.81A 3fpjB-4fc2A:
undetectable		 3fpjB-4fc2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 GLY A 535
GLY A 531
GLU A 460
ALA A 537
 None
None
EDO  A 821 (-2.8A)
None
 0.76A 3fpjB-4fusA:
undetectable		 3fpjB-4fusA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g41 MTA/SAH NUCLEOSIDASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		4 GLY A  49
GLY A  51
GLU A 174
GLU A  10
 GLY  A  49 ( 0.0A)
GLY  A  51 ( 0.0A)
GLU  A 174 ( 0.6A)
GLU  A  10 ( 0.6A)
 0.87A 3fpjB-4g41A:
undetectable		 3fpjB-4g41A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 14

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		4 GLN N  60
GLY N 427
GLY N  45
ALA N 422
 None
 0.86A 3fpjB-4heaN:
undetectable		 3fpjB-4heaN:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hg2 METHYLTRANSFERASE
TYPE 11

(Anaeromyxobacter
dehalogenans) 		PF08241
(Methyltransf_11) 		4 GLN A  49
GLY A  44
GLY A  46
GLU A  88
 None
 0.73A 3fpjB-4hg2A:
11.9		 3fpjB-4hg2A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN

(Neisseria
gonorrhoeae) 		PF01554
(MatE) 		4 GLY A 309
GLY A 389
GLU A 316
ALA A  82
 None
 0.81A 3fpjB-4humA:
undetectable		 3fpjB-4humA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		4 GLY A 203
GLY A 194
GLU A 224
ALA A 236
 None
LLP  A 196 ( 4.4A)
None
None
 0.82A 3fpjB-4ixoA:
2.6		 3fpjB-4ixoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		4 GLN B 246
GLY B  88
GLY B 220
ALA B  91
 None
LLP  B 210 ( 3.3A)
None
None
 0.82A 3fpjB-4iyoB:
2.4		 3fpjB-4iyoB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 GLN A 599
GLY A 790
GLY A 787
GLU A 889
 None
 0.80A 3fpjB-4nmeA:
5.8		 3fpjB-4nmeA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 343
GLY A 345
GLU A 319
ALA A 187
 None
 0.83A 3fpjB-4nzsA:
undetectable		 3fpjB-4nzsA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oju HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Pseudoflavonifractor
capillosus) 		PF13306
(LRR_5) 		4 GLY A  81
GLY A 103
GLU A  39
ALA A  84
 None
 0.83A 3fpjB-4ojuA:
undetectable		 3fpjB-4ojuA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 GLY A  90
GLY A  92
GLU A 112
GLU A 141
 SAH  A1000 (-3.2A)
SAH  A1000 ( 3.7A)
SAH  A1000 (-2.7A)
SAH  A1000 (-3.3A)
 0.78A 3fpjB-4qppA:
7.6		 3fpjB-4qppA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsl FRUCTOSYL PEPTIDE
OXIDASE

(Penicillium
terrenum) 		PF01266
(DAO) 		4 GLY A  14
GLY A  16
THR A  23
ALA A 219
 FAD  A 502 (-3.6A)
FAD  A 502 (-4.2A)
None
None
 0.86A 3fpjB-4rslA:
3.3		 3fpjB-4rslA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucw HYDROGENASE (NIFE)
SMALL SUBUNIT HYDA

(Desulfovibrio
fructosivorans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 GLY A 132
GLY A  77
THR A  80
ALA A 136
 None
 0.86A 3fpjB-4ucwA:
undetectable		 3fpjB-4ucwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		4 GLY A  10
THR A  18
GLU A  33
ALA A 208
 FAD  A 401 (-3.2A)
None
FAD  A 401 (-2.9A)
None
 0.73A 3fpjB-4x9nA:
3.1		 3fpjB-4x9nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsv ETHANOLAMINE-PHOSPHA
TE
CYTIDYLYLTRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		4 GLY A 248
GLY A 220
GLU A 283
ALA A 288
 None
C5P  A 401 (-3.1A)
None
None
 0.86A 3fpjB-4xsvA:
3.1		 3fpjB-4xsvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		4 GLN A 329
GLY A 298
GLY A 295
ALA A 303
 None
None
PYR  A 601 (-3.3A)
None
 0.88A 3fpjB-4yj5A:
2.5		 3fpjB-4yj5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn6 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Acinetobacter
baumannii) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  17
GLY A  20
THR A  26
ALA A 109
 None
 0.85A 3fpjB-4zn6A:
4.3		 3fpjB-4zn6A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A  12
GLY A  15
THR A  21
ALA A 103
 NAD  A 501 (-3.3A)
NAD  A 501 (-3.4A)
None
NAD  A 501 (-4.4A)
 0.84A 3fpjB-4zqgA:
4.3		 3fpjB-4zqgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE

(Streptomyces
sp. CNQ-418) 		PF04820
(Trp_halogenase) 		4 GLY A  11
THR A  19
GLU A  34
ALA A 177
 FAD  A 501 (-3.3A)
None
FAD  A 501 (-2.8A)
None
 0.86A 3fpjB-5bukA:
2.5		 3fpjB-5bukA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 GLY A 101
GLY A 103
GLU A 125
ALA A 170
 None
 0.87A 3fpjB-5c1iA:
15.1		 3fpjB-5c1iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLY A 277
GLY A 279
THR A 149
ALA A 244
 None
 0.72A 3fpjB-5cerA:
undetectable		 3fpjB-5cerA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyn LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF02217
(T_Ag_DNA_bind) 		4 GLY A 189
GLY A 191
GLU A 246
ALA A 243
 None
 0.84A 3fpjB-5cynA:
undetectable		 3fpjB-5cynA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dds CRMG

(Actinoalloteichus
sp. WH1-2216-6) 		PF00202
(Aminotran_3) 		4 GLN A 318
GLY A 289
GLY A 286
ALA A 436
 PLP  A 601 (-3.4A)
None
None
None
 0.72A 3fpjB-5ddsA:
undetectable		 3fpjB-5ddsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 GLY B 760
GLU B 759
GLU B 782
ALA B 906
 None
 0.82A 3fpjB-5gjeB:
undetectable		 3fpjB-5gjeB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00180
(Iso_dh) 		5 GLN A 134
GLY A  84
GLY A 131
THR A  99
ALA A  87
 None
 1.16A 3fpjB-5j32A:
undetectable		 3fpjB-5j32A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12
WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens;
Homo sapiens) 		PF00443
(UCH)
PF00400
(WD40) 		4 GLN C 374
GLY C  44
THR A 351
GLU A 345
 None
 0.87A 3fpjB-5k1cC:
undetectable		 3fpjB-5k1cC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 GLY A   8
GLY A  11
THR A  17
ALA A 100
 None
 0.79A 3fpjB-5ks1A:
4.1		 3fpjB-5ks1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lo9 CYTOCHROME C

(Marichromatium
purpuratum) 		PF00034
(Cytochrom_C)
PF13442
(Cytochrome_CBB3) 		4 GLN A 477
GLY A 501
GLY A 512
ALA A 489
 None
 0.72A 3fpjB-5lo9A:
undetectable		 3fpjB-5lo9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mf1 FUSION PROTEIN
HAP2/GCS1

(Chlamydomonas
reinhardtii) 		PF10699
(HAP2-GCS1) 		4 GLN A 394
GLY A 363
GLY A 370
ALA A 375
 None
 0.68A 3fpjB-5mf1A:
undetectable		 3fpjB-5mf1A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLN A 395
GLY A 385
THR A 389
ALA A 380
 None
 0.70A 3fpjB-5nitA:
4.0		 3fpjB-5nitA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLY A  26
THR A  34
GLU A  50
ALA A 288
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-2.7A)
None
 0.75A 3fpjB-5nitA:
4.0		 3fpjB-5nitA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		4 GLY A 150
THR A 158
GLU A 173
ALA A 327
 FAD  A 701 (-3.2A)
None
FAD  A 701 (-2.9A)
None
 0.73A 3fpjB-5odrA:
5.1		 3fpjB-5odrA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t57 SEMIALDEHYDE
DEHYDROGENASE
NAD-BINDING PROTEIN

(Cupriavidus
necator) 		PF03807
(F420_oxidored)
PF16896
(PGDH_C) 		4 GLY A   9
GLY A  11
GLU A  33
ALA A  66
 NAD  A 301 (-3.4A)
NAD  A 301 (-4.3A)
NAD  A 301 (-2.7A)
NAD  A 301 (-4.6A)
 0.77A 3fpjB-5t57A:
6.4		 3fpjB-5t57A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 4 GLY A 601
GLY A 564
THR A 631
ALA A 299
 None
 0.54A 3fpjB-5ta1A:
undetectable		 3fpjB-5ta1A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		4 GLY A 186
GLY A 182
THR A 201
ALA A  59
 None
 0.73A 3fpjB-5tsbA:
undetectable		 3fpjB-5tsbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txr 5-AMINOLEVULINATE
SYNTHASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 4 GLY B 295
GLY B 290
GLU B 298
ALA B 285
 None
 0.87A 3fpjB-5txrB:
2.3		 3fpjB-5txrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 GLN A 253
GLY A 187
GLY A 165
ALA A 190
 None
 0.77A 3fpjB-5vawA:
undetectable		 3fpjB-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r 30S RIBOSOMAL
PROTEIN S5,
CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 GLY e 244
GLY e 246
THR e 222
ALA e 242
 None
None
None
U  a   6 ( 3.2A)
 0.82A 3fpjB-5x8re:
undetectable		 3fpjB-5x8re:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccz SERINE
HYDROXYMETHYLTRANSFE
RASE

(Medicago
truncatula) 		no annotation 4 GLN A 382
GLY A 466
GLU A 469
ALA A 389
 None
 0.87A 3fpjB-6cczA:
3.9		 3fpjB-6cczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLY X 475
GLY X 445
GLU X 299
ALA X 478
 BF8  X 702 ( 4.1A)
BF8  X 702 (-4.2A)
None
None
 0.85A 3fpjB-6elqX:
3.9		 3fpjB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1

(Homo sapiens;
Mus musculus) 		no annotation 4 GLY A 308
GLY A 311
GLU A 711
ALA A 316
 None
 0.87A 3fpjB-6fuzA:
undetectable		 3fpjB-6fuzA:
undetectable