SIMILAR PATTERNS OF AMINO ACIDS FOR 3FPJ_A_SAMA301_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 GLY A 228
VAL A 230
ILE A 257
ALA A 205
VAL A 241
 None
 1.01A 3fpjA-1czfA:
undetectable		 3fpjA-1czfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 533
VAL A 535
ILE A 511
ALA A 136
VAL A 309
 FAD  A 600 (-3.5A)
None
None
FAD  A 600 (-3.3A)
None
 1.00A 3fpjA-1d4eA:
3.0		 3fpjA-1d4eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		5 ILE A  82
GLY A  83
VAL A 106
ILE A 112
VAL A 154
 None
SAH  A 699 (-3.2A)
SAH  A 699 (-4.7A)
SAH  A 699 ( 4.5A)
None
 1.00A 3fpjA-1dl5A:
9.5		 3fpjA-1dl5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		6 ILE A 103
GLY A  92
VAL A  95
ILE A 128
ALA A  91
VAL A 152
 None
 1.41A 3fpjA-1ghsA:
undetectable		 3fpjA-1ghsA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 GLY A 207
VAL A 209
ILE A 236
ALA A 184
VAL A 220
 None
 0.98A 3fpjA-1ia5A:
undetectable		 3fpjA-1ia5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT

(Galdieria
partita) 		PF00101
(RuBisCO_small) 		5 ILE B  40
GLY B  41
VAL B 101
LEU B  72
VAL B  77
 None
 0.99A 3fpjA-1iwaB:
undetectable		 3fpjA-1iwaB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 144
ILE A 158
VAL A 141
ILE A 137
ALA A 161
 None
 0.94A 3fpjA-1n3sA:
undetectable		 3fpjA-1n3sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 6 ILE A  10
GLY A 196
VAL A 195
ALA A  11
LEU A  46
VAL A  53
 None
 1.21A 3fpjA-1nnwA:
undetectable		 3fpjA-1nnwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 ILE B  10
GLY B  11
VAL B  36
ILE B  38
ALA B  78
 NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
None
NAD  B3501 (-4.2A)
NAD  B3501 (-4.7A)
 0.58A 3fpjA-1nvmB:
5.3		 3fpjA-1nvmB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PHE A 483
ILE A 482
ILE A 303
ALA A 480
VAL A 510
 None
 0.94A 3fpjA-1o0sA:
2.3		 3fpjA-1o0sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 MET A 104
ILE A  89
ALA A  85
LEU A  82
VAL A  56
 None
 0.92A 3fpjA-1oi7A:
4.4		 3fpjA-1oi7A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ILE A  76
GLY A  75
VAL A  72
ALA A  78
VAL A 142
 None
 0.96A 3fpjA-1pl0A:
2.2		 3fpjA-1pl0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 ILE B 162
GLY B 171
ILE B  50
ALA B 161
VAL B 140
 None
 1.00A 3fpjA-1qdlB:
undetectable		 3fpjA-1qdlB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 ILE A 217
VAL A 188
ALA A  24
LEU A  23
VAL A 204
 None
 1.01A 3fpjA-1uxtA:
4.8		 3fpjA-1uxtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 ILE A 466
GLY A 467
VAL A 426
LEU A 390
VAL A 487
 None
 0.91A 3fpjA-1wkyA:
undetectable		 3fpjA-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
capsulatus;
Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		5 GLN D 226
GLY C  89
VAL C  87
ALA C  92
VAL C  64
 None
 0.96A 3fpjA-1zrtD:
undetectable		 3fpjA-1zrtD:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ILE A  63
GLY A  62
ILE A  31
ALA A  65
VAL A  74
 None
 1.01A 3fpjA-2a18A:
undetectable		 3fpjA-2a18A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1b CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ILE A  61
GLY A  60
VAL A  57
ALA A  63
VAL A  72
 None
 1.02A 3fpjA-2a1bA:
undetectable		 3fpjA-2a1bA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 PHE A 632
ILE A 661
VAL A 631
ILE A 641
LEU A 676
 None
 0.97A 3fpjA-2bf4A:
3.1		 3fpjA-2bf4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		6 MET A 201
ILE A   8
GLY A  15
ILE A 356
ALA A  11
VAL A  29
 None
 1.30A 3fpjA-2bi7A:
3.3		 3fpjA-2bi7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Pyrococcus
horikoshii) 		PF01967
(MoaC) 		5 ILE A  63
GLY A  62
ILE A 124
ALA A  65
VAL A  84
 None
 0.99A 3fpjA-2eknA:
undetectable		 3fpjA-2eknA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.94A 3fpjA-2fncA:
undetectable		 3fpjA-2fncA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		6 ILE A  19
ILE A  78
ILE A 103
ALA A  75
LEU A  99
VAL A  64
 None
 1.41A 3fpjA-2fpgA:
3.2		 3fpjA-2fpgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 GLY A 132
ILE A 235
ILE A 295
LEU A 137
VAL A 147
 None
 0.93A 3fpjA-2fqxA:
3.1		 3fpjA-2fqxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE A 262
ILE A 263
GLY A 264
VAL A 332
VAL A 275
 None
 0.89A 3fpjA-2g4bA:
undetectable		 3fpjA-2g4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.89A 3fpjA-2ghbA:
undetectable		 3fpjA-2ghbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		5 ILE A  64
GLY A  63
VAL A  60
ALA A  66
VAL A  74
 None
 1.01A 3fpjA-2gsjA:
undetectable		 3fpjA-2gsjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
NAI  A 601 (-3.3A)
None
NAI  A 601 (-3.8A)
None
 0.57A 3fpjA-2hmsA:
5.9		 3fpjA-2hmsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF09455
(Cas_DxTHG) 		5 ILE A  51
GLY A  50
ILE A 130
ALA A  88
VAL A 262
 None
 0.93A 3fpjA-2i71A:
2.3		 3fpjA-2i71A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 156
VAL A 207
ILE A   6
LEU A 159
VAL A  35
 ILE  A 156 ( 0.7A)
VAL  A 207 ( 0.6A)
ILE  A   6 ( 0.7A)
LEU  A 159 ( 0.6A)
VAL  A  35 ( 0.6A)
 0.98A 3fpjA-2nvvA:
undetectable		 3fpjA-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 ILE A 283
ILE A 174
ILE A 211
ALA A 177
VAL A 293
 None
 1.02A 3fpjA-2ok8A:
2.9		 3fpjA-2ok8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		5 ILE A  75
VAL A  77
ILE A 140
ALA A  74
VAL A  90
 None
None
None
None
EDO  A 275 ( 4.4A)
 0.90A 3fpjA-2p4gA:
2.6		 3fpjA-2p4gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		6 PHE A 126
ILE A 108
ILE A 136
ILE A  64
ALA A 109
VAL A  51
 None
 1.47A 3fpjA-2ph0A:
undetectable		 3fpjA-2ph0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 ILE A 187
GLY A 156
ILE A 129
ILE A  70
VAL A 181
 None
 0.99A 3fpjA-2przA:
2.4		 3fpjA-2przA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF00690
(Cation_ATPase_N)
no annotation
PF00122
(E1-E2_ATPase) 		5 VAL E  93
ILE E  97
ALA B  69
LEU B  66
VAL H 304
 None
 1.02A 3fpjA-2voyE:
undetectable		 3fpjA-2voyE:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 ILE A 151
GLY A 160
ILE A  47
ALA A 150
VAL A 130
 None
 0.94A 3fpjA-2ywbA:
undetectable		 3fpjA-2ywbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 PHE A 129
ILE A 176
GLY A 175
VAL A  86
LEU A 173
 None
 1.02A 3fpjA-3aqgA:
undetectable		 3fpjA-3aqgA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 283
GLY A 282
VAL A 314
ALA A 285
VAL A 305
 None
 0.90A 3fpjA-3boeA:
undetectable		 3fpjA-3boeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 283
GLY A 282
VAL A 314
ILE A 260
VAL A 305
 None
 0.89A 3fpjA-3boeA:
undetectable		 3fpjA-3boeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A  73
GLY A  72
VAL A 104
ALA A  75
VAL A  95
 None
 0.88A 3fpjA-3bohA:
undetectable		 3fpjA-3bohA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A  73
GLY A  72
VAL A 104
ILE A  50
VAL A  95
 None
 0.89A 3fpjA-3bohA:
undetectable		 3fpjA-3bohA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cim CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp.) 		PF00936
(BMC) 		5 ILE A  61
GLY A  60
VAL A  57
ALA A  63
VAL A  72
 None
 0.95A 3fpjA-3cimA:
undetectable		 3fpjA-3cimA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN

(Coccidioides
immitis) 		PF12849
(PBP_like_2) 		5 ILE A  42
GLY A  43
VAL A  95
ILE A  85
VAL A  53
 None
 1.01A 3fpjA-3cvgA:
undetectable		 3fpjA-3cvgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 GLN A 342
PHE A 104
ILE A 103
GLY A 102
VAL A  72
 None
 1.01A 3fpjA-3czpA:
undetectable		 3fpjA-3czpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 ILE A  41
VAL A  43
ILE A 102
ALA A  40
VAL A  69
 None
 0.91A 3fpjA-3daqA:
undetectable		 3fpjA-3daqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 ILE A   3
GLY A   4
VAL A  70
ILE A 179
VAL A 227
 None
 0.85A 3fpjA-3dp9A:
undetectable		 3fpjA-3dp9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 GLN A 379
ILE A 271
VAL A 273
ALA A 237
ARG A 293
 None
 1.00A 3fpjA-3gg0A:
undetectable		 3fpjA-3gg0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		5 ILE A  24
GLY A  25
VAL A  50
ALA A 143
VAL A 139
 None
 0.94A 3fpjA-3innA:
undetectable		 3fpjA-3innA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		6 PHE A 404
ILE A 405
GLY A 406
ILE A 436
ALA A 429
VAL A 414
 None
 1.29A 3fpjA-3lq1A:
undetectable		 3fpjA-3lq1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159

(Methanocaldococcus
jannaschii) 		PF01995
(DUF128) 		5 PHE A 427
ILE A 417
GLY A 416
ALA A 456
VAL A 448
 None
 0.90A 3fpjA-3nekA:
undetectable		 3fpjA-3nekA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		11 GLN A  81
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ILE A 158
ALA A 195
LEU A 197
ARG A 203
VAL A 204
 3O3  A   1 ( 4.8A)
BR  A 298 ( 4.8A)
None
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
None
 0.36A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		9 MET A  78
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ALA A 195
LEU A 197
VAL A 204
 None
BR  A 298 ( 4.8A)
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
 1.03A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		6 ILE A   3
GLY A   4
VAL A  70
ILE A 178
ALA A  44
LEU A  45
 None
 1.37A 3fpjA-3o4vA:
undetectable		 3fpjA-3o4vA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)

(Shewanella sp.
W3-18-1) 		PF01717
(Meth_synt_2) 		5 ILE A 204
GLY A 203
VAL A 199
ILE A 148
ALA A 205
 None
 1.02A 3fpjA-3rpdA:
undetectable		 3fpjA-3rpdA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 PHE A 225
ILE A 226
GLY A 227
VAL A 242
ALA A 209
 None
 0.69A 3fpjA-3t57A:
undetectable		 3fpjA-3t57A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 GLY A 287
VAL A 284
ILE A 717
ALA A 290
VAL A 394
 None
 0.98A 3fpjA-3ue1A:
undetectable		 3fpjA-3ue1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 493
GLY A 492
VAL A 524
ALA A 495
VAL A 515
 None
 0.88A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 493
GLY A 492
VAL A 524
ILE A 470
VAL A 515
 None
 0.86A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		5 PHE A 314
ILE A 313
ILE A 425
ILE A 450
ALA A 431
 None
 1.00A 3fpjA-4apmA:
undetectable		 3fpjA-4apmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 179
GLY A 180
VAL A 192
ILE A 189
ALA A 176
 EDO  A 642 ( 3.7A)
None
None
None
EDO  A 642 (-4.1A)
 1.02A 3fpjA-4bjpA:
undetectable		 3fpjA-4bjpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 ILE P 478
ILE P 523
ILE P 395
ALA P 481
VAL P 509
 None
 1.02A 3fpjA-4crmP:
undetectable		 3fpjA-4crmP:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 143
ILE A 157
VAL A 140
ILE A 136
ALA A 160
 None
 0.87A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 143
VAL A 140
ILE A 136
ALA A 160
VAL A 170
 None
 1.01A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		5 ILE B 302
GLY B 303
VAL B 375
ILE B 380
ALA B 140
 None
 0.93A 3fpjA-4g68B:
undetectable		 3fpjA-4g68B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		6 PHE A 273
ILE A 272
GLY A 271
VAL A 269
ALA A 106
VAL A  86
 None
 1.29A 3fpjA-4gcmA:
undetectable		 3fpjA-4gcmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		5 ILE A 220
ILE A 162
ALA A 165
LEU A 144
VAL A 203
 None
 0.99A 3fpjA-4hn3A:
undetectable		 3fpjA-4hn3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME

(Escherichia
virus T4;
Aquifex
aeolicus) 		PF00902
(TatC) 		5 ILE A 162
GLY A 161
VAL A 158
ILE A  74
LEU A 110
 None
 1.01A 3fpjA-4httA:
undetectable		 3fpjA-4httA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ILE A  37
GLY A  38
VAL A  60
ILE A  66
ALA A 290
 FAD  A 501 (-4.7A)
FAD  A 501 (-3.2A)
None
None
None
 0.90A 3fpjA-4i59A:
undetectable		 3fpjA-4i59A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
ADP  A 601 (-3.4A)
None
ADP  A 601 (-3.9A)
None
 0.65A 3fpjA-4j91A:
5.9		 3fpjA-4j91A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 ILE A 315
GLY A 313
ILE A 350
ALA A 316
LEU A 343
 None
 0.82A 3fpjA-4ldsA:
undetectable		 3fpjA-4ldsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 GLY A  20
VAL A  42
ILE A  44
ALA A 331
VAL A 340
 FDA  A 801 (-3.4A)
None
FDA  A 801 (-3.7A)
None
None
 0.62A 3fpjA-4mifA:
2.7		 3fpjA-4mifA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ILE A 160
GLY A 159
VAL A 156
ILE A  43
VAL A 180
 None
 0.85A 3fpjA-4o1jA:
undetectable		 3fpjA-4o1jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 ILE A 317
GLY A 298
ILE A 221
ILE A 255
VAL A 379
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 PHE A 296
ILE A 297
GLY A 298
VAL A 315
ALA A 222
 None
 0.76A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 PHE A 296
ILE A 297
GLY A 298
VAL A 315
VAL A 241
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		5 GLY A 206
VAL A   5
ILE A   2
ALA A 186
LEU A 185
 None
 0.92A 3fpjA-4u9pA:
undetectable		 3fpjA-4u9pA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 ILE A 126
VAL A 239
ILE A 228
ALA A 129
VAL A 138
 None
ADN  A 301 ( 4.2A)
ADN  A 301 (-3.8A)
None
None
 0.96A 3fpjA-4x3mA:
undetectable		 3fpjA-4x3mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
 0.66A 3fpjA-5butA:
6.6		 3fpjA-5butA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A 154
GLY A 155
VAL A 177
ILE A 179
ALA A 219
 None
 0.66A 3fpjA-5butA:
6.6		 3fpjA-5butA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR)
PF02775
(TPP_enzyme_C) 		5 ILE C   5
VAL C 201
ILE B 269
ILE C 197
ALA C  39
 None
 0.99A 3fpjA-5exeC:
2.5		 3fpjA-5exeC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 ILE M  41
ILE M  50
ILE M 225
ALA M  53
LEU M 221
 None
 0.95A 3fpjA-5fmgM:
undetectable		 3fpjA-5fmgM:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ILE A 494
GLY A 195
ILE A 192
ILE A 235
VAL A 180
 None
 0.90A 3fpjA-5gz4A:
undetectable		 3fpjA-5gz4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 GLY B 317
VAL B 315
ILE B 313
ALA B 320
LEU B 282
 None
 1.00A 3fpjA-5hzgB:
undetectable		 3fpjA-5hzgB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 GLN A  37
ILE A 415
VAL A 460
ILE A 458
ALA A 399
 None
 0.98A 3fpjA-5k0tA:
undetectable		 3fpjA-5k0tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 VAL A 420
ILE A 424
ILE A 426
ALA A 307
LEU A 304
 None
 0.96A 3fpjA-5k3jA:
undetectable		 3fpjA-5k3jA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		5 ILE A 230
GLY A 231
VAL A 178
LEU A 268
VAL A 218
 None
 0.97A 3fpjA-5lgxA:
undetectable		 3fpjA-5lgxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		5 PHE A  34
ILE A  33
GLY A  32
VAL A  46
ALA A   7
 None
 0.99A 3fpjA-5loaA:
3.2		 3fpjA-5loaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 ILE A 149
GLY A 150
VAL A 172
ALA A 327
VAL A 504
 FAD  A 701 (-4.9A)
FAD  A 701 (-3.2A)
None
None
None
 0.46A 3fpjA-5odrA:
undetectable		 3fpjA-5odrA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3j INOSITOL
MONOPHOSPHATASE

(Medicago
truncatula) 		PF00459
(Inositol_P) 		6 ILE A 165
GLY A 176
ILE A 178
ILE A 278
ALA A 166
LEU A 272
 None
 1.41A 3fpjA-5t3jA:
undetectable		 3fpjA-5t3jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 ILE A 168
ILE A 173
ILE A 133
LEU A 232
VAL A 155
 None
 1.02A 3fpjA-5turA:
undetectable		 3fpjA-5turA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ILE A   3
GLY A   4
VAL A  70
ILE A 179
VAL A 227
 None
 0.86A 3fpjA-5ue1A:
undetectable		 3fpjA-5ue1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		5 ILE A 123
GLY A 124
VAL A 172
ILE A 169
ALA A 210
 None
 1.00A 3fpjA-5vmkA:
undetectable		 3fpjA-5vmkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0h SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 PHE A 262
ILE A 263
GLY A 264
VAL A 332
VAL A 275
 None
 0.93A 3fpjA-5w0hA:
undetectable		 3fpjA-5w0hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 ILE A  48
GLY A  49
VAL A  93
ILE A  17
ALA A  31
 None
None
CL  A 302 (-4.6A)
None
None
 0.99A 3fpjA-5wl7A:
undetectable		 3fpjA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 ILE A 103
GLY A  85
ILE A  30
LEU A  91
VAL A 101
 None
 0.99A 3fpjA-5x4jA:
undetectable		 3fpjA-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 5 MET A 208
ILE A 443
GLY A 440
ALA A 423
LEU A 420
 None
 0.97A 3fpjA-5xviA:
3.4		 3fpjA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y51 -

(-) 		no annotation 5 ILE A 192
GLY A  97
VAL A  95
ILE A   6
LEU A 195
 None
 1.00A 3fpjA-5y51A:
undetectable		 3fpjA-5y51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 ILE A  56
GLY A  57
ILE A 350
ALA A  86
VAL A  72
 None
 1.02A 3fpjA-6bj9A:
undetectable		 3fpjA-6bj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 ILE A 515
GLY A 216
ILE A 213
ILE A 256
VAL A 201
 None
 0.92A 3fpjA-6f2tA:
undetectable		 3fpjA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 ILE B1071
GLY B1074
VAL B1070
ALA A1088
VAL A1411
 None
 1.00A 3fpjA-6f42B:
undetectable		 3fpjA-6f42B:
undetectable