SIMILAR PATTERNS OF AMINO ACIDS FOR 3FPJ_A_SAMA301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1czf POLYGALACTURONASE II

(Aspergillus
niger) 		PF00295
(Glyco_hydro_28) 		5 GLY A 228
VAL A 230
ILE A 257
ALA A 205
VAL A 241
 None
 1.01A 3fpjA-1czfA:
undetectable		 3fpjA-1czfA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 GLY A 533
VAL A 535
ILE A 511
ALA A 136
VAL A 309
 FAD  A 600 (-3.5A)
None
None
FAD  A 600 (-3.3A)
None
 1.00A 3fpjA-1d4eA:
3.0		 3fpjA-1d4eA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dl5 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01135
(PCMT) 		5 ILE A  82
GLY A  83
VAL A 106
ILE A 112
VAL A 154
 None
SAH  A 699 (-3.2A)
SAH  A 699 (-4.7A)
SAH  A 699 ( 4.5A)
None
 1.00A 3fpjA-1dl5A:
9.5		 3fpjA-1dl5A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		6 ILE A 103
GLY A  92
VAL A  95
ILE A 128
ALA A  91
VAL A 152
 None
 1.41A 3fpjA-1ghsA:
undetectable		 3fpjA-1ghsA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia5 POLYGALACTURONASE

(Aspergillus
aculeatus) 		PF00295
(Glyco_hydro_28) 		5 GLY A 207
VAL A 209
ILE A 236
ALA A 184
VAL A 220
 None
 0.98A 3fpjA-1ia5A:
undetectable		 3fpjA-1ia5A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwa RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E SMALL SUBUNIT

(Galdieria
partita) 		PF00101
(RuBisCO_small) 		5 ILE B  40
GLY B  41
VAL B 101
LEU B  72
VAL B  77
 None
 0.99A 3fpjA-1iwaB:
undetectable		 3fpjA-1iwaB:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 144
ILE A 158
VAL A 141
ILE A 137
ALA A 161
 None
 0.94A 3fpjA-1n3sA:
undetectable		 3fpjA-1n3sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 6 ILE A  10
GLY A 196
VAL A 195
ALA A  11
LEU A  46
VAL A  53
 None
 1.21A 3fpjA-1nnwA:
undetectable		 3fpjA-1nnwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 ILE B  10
GLY B  11
VAL B  36
ILE B  38
ALA B  78
 NAD  B3501 (-4.9A)
NAD  B3501 (-3.2A)
None
NAD  B3501 (-4.2A)
NAD  B3501 (-4.7A)
 0.58A 3fpjA-1nvmB:
5.3		 3fpjA-1nvmB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		5 PHE A 483
ILE A 482
ILE A 303
ALA A 480
VAL A 510
 None
 0.94A 3fpjA-1o0sA:
2.3		 3fpjA-1o0sA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 MET A 104
ILE A  89
ALA A  85
LEU A  82
VAL A  56
 None
 0.92A 3fpjA-1oi7A:
4.4		 3fpjA-1oi7A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 ILE A  76
GLY A  75
VAL A  72
ALA A  78
VAL A 142
 None
 0.96A 3fpjA-1pl0A:
2.2		 3fpjA-1pl0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPG-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00117
(GATase) 		5 ILE B 162
GLY B 171
ILE B  50
ALA B 161
VAL B 140
 None
 1.00A 3fpjA-1qdlB:
undetectable		 3fpjA-1qdlB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 ILE A 217
VAL A 188
ALA A  24
LEU A  23
VAL A 204
 None
 1.01A 3fpjA-1uxtA:
4.8		 3fpjA-1uxtA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 ILE A 466
GLY A 467
VAL A 426
LEU A 390
VAL A 487
 None
 0.91A 3fpjA-1wkyA:
undetectable		 3fpjA-1wkyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrt CYTOCHROME B
CYTOCHROME C1

(Rhodobacter
capsulatus;
Rhodobacter
capsulatus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B)
PF02167
(Cytochrom_C1) 		5 GLN D 226
GLY C  89
VAL C  87
ALA C  92
VAL C  64
 None
 0.96A 3fpjA-1zrtD:
undetectable		 3fpjA-1zrtD:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ILE A  63
GLY A  62
ILE A  31
ALA A  65
VAL A  74
 None
 1.01A 3fpjA-2a18A:
undetectable		 3fpjA-2a18A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1b CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp. PCC 6803) 		PF00936
(BMC) 		5 ILE A  61
GLY A  60
VAL A  57
ALA A  63
VAL A  72
 None
 1.02A 3fpjA-2a1bA:
undetectable		 3fpjA-2a1bA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 PHE A 632
ILE A 661
VAL A 631
ILE A 641
LEU A 676
 None
 0.97A 3fpjA-2bf4A:
3.1		 3fpjA-2bf4A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE

(Klebsiella
pneumoniae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		6 MET A 201
ILE A   8
GLY A  15
ILE A 356
ALA A  11
VAL A  29
 None
 1.30A 3fpjA-2bi7A:
3.3		 3fpjA-2bi7A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekn PROBABLE MOLYBDENUM
COFACTOR
BIOSYNTHESIS PROTEIN
C

(Pyrococcus
horikoshii) 		PF01967
(MoaC) 		5 ILE A  63
GLY A  62
ILE A 124
ALA A  65
VAL A  84
 None
 0.99A 3fpjA-2eknA:
undetectable		 3fpjA-2eknA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.94A 3fpjA-2fncA:
undetectable		 3fpjA-2fncA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		6 ILE A  19
ILE A  78
ILE A 103
ALA A  75
LEU A  99
VAL A  64
 None
 1.41A 3fpjA-2fpgA:
3.2		 3fpjA-2fpgA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 GLY A 132
ILE A 235
ILE A 295
LEU A 137
VAL A 147
 None
 0.93A 3fpjA-2fqxA:
3.1		 3fpjA-2fqxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4b SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		PF00076
(RRM_1) 		5 PHE A 262
ILE A 263
GLY A 264
VAL A 332
VAL A 275
 None
 0.89A 3fpjA-2g4bA:
undetectable		 3fpjA-2g4bA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghb MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		5 ILE A 139
GLY A 149
VAL A 147
ALA A 136
VAL A 122
 None
 0.89A 3fpjA-2ghbA:
undetectable		 3fpjA-2ghbA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsj PROTEIN PPL-2

(Parkia
platycephala) 		PF00704
(Glyco_hydro_18) 		5 ILE A  64
GLY A  63
VAL A  60
ALA A  66
VAL A  74
 None
 1.01A 3fpjA-2gsjA:
undetectable		 3fpjA-2gsjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
NAI  A 601 (-3.3A)
None
NAI  A 601 (-3.8A)
None
 0.57A 3fpjA-2hmsA:
5.9		 3fpjA-2hmsA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i71 HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF09455
(Cas_DxTHG) 		5 ILE A  51
GLY A  50
ILE A 130
ALA A  88
VAL A 262
 None
 0.93A 3fpjA-2i71A:
2.3		 3fpjA-2i71A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ILE A 156
VAL A 207
ILE A   6
LEU A 159
VAL A  35
 ILE  A 156 ( 0.7A)
VAL  A 207 ( 0.6A)
ILE  A   6 ( 0.7A)
LEU  A 159 ( 0.6A)
VAL  A  35 ( 0.6A)
 0.98A 3fpjA-2nvvA:
undetectable		 3fpjA-2nvvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ok8 PUTATIVE
FERREDOXIN--NADP
REDUCTASE

(Plasmodium
falciparum) 		PF00175
(NAD_binding_1) 		5 ILE A 283
ILE A 174
ILE A 211
ALA A 177
VAL A 293
 None
 1.02A 3fpjA-2ok8A:
2.9		 3fpjA-2ok8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4g HYPOTHETICAL PROTEIN

(Corynebacterium
diphtheriae) 		PF01872
(RibD_C) 		5 ILE A  75
VAL A  77
ILE A 140
ALA A  74
VAL A  90
 None
None
None
None
EDO  A 275 ( 4.4A)
 0.90A 3fpjA-2p4gA:
2.6		 3fpjA-2p4gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN

(Pectobacterium
carotovorum) 		PF06228
(ChuX_HutX) 		6 PHE A 126
ILE A 108
ILE A 136
ILE A  64
ALA A 109
VAL A  51
 None
 1.47A 3fpjA-2ph0A:
undetectable		 3fpjA-2ph0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1

(Saccharomyces
cerevisiae) 		PF00156
(Pribosyltran) 		5 ILE A 187
GLY A 156
ILE A 129
ILE A  70
VAL A 181
 None
 0.99A 3fpjA-2przA:
2.4		 3fpjA-2przA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2voy SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Oryctolagus
cuniculus;
Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		PF00690
(Cation_ATPase_N)
no annotation
PF00122
(E1-E2_ATPase) 		5 VAL E  93
ILE E  97
ALA B  69
LEU B  66
VAL H 304
 None
 1.02A 3fpjA-2voyE:
undetectable		 3fpjA-2voyE:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		5 ILE A 151
GLY A 160
ILE A  47
ALA A 150
VAL A 130
 None
 0.94A 3fpjA-2ywbA:
undetectable		 3fpjA-2ywbA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B

(Homo sapiens) 		PF01419
(Jacalin) 		5 PHE A 129
ILE A 176
GLY A 175
VAL A  86
LEU A 173
 None
 1.02A 3fpjA-3aqgA:
undetectable		 3fpjA-3aqgA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 283
GLY A 282
VAL A 314
ALA A 285
VAL A 305
 None
 0.90A 3fpjA-3boeA:
undetectable		 3fpjA-3boeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boe CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 283
GLY A 282
VAL A 314
ILE A 260
VAL A 305
 None
 0.89A 3fpjA-3boeA:
undetectable		 3fpjA-3boeA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A  73
GLY A  72
VAL A 104
ALA A  75
VAL A  95
 None
 0.88A 3fpjA-3bohA:
undetectable		 3fpjA-3bohA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3boh CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A  73
GLY A  72
VAL A 104
ILE A  50
VAL A  95
 None
 0.89A 3fpjA-3bohA:
undetectable		 3fpjA-3bohA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cim CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 2

(Synechocystis
sp.) 		PF00936
(BMC) 		5 ILE A  61
GLY A  60
VAL A  57
ALA A  63
VAL A  72
 None
 0.95A 3fpjA-3cimA:
undetectable		 3fpjA-3cimA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvg PUTATIVE METAL
BINDING PROTEIN

(Coccidioides
immitis) 		PF12849
(PBP_like_2) 		5 ILE A  42
GLY A  43
VAL A  95
ILE A  85
VAL A  53
 None
 1.01A 3fpjA-3cvgA:
undetectable		 3fpjA-3cvgA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		5 GLN A 342
PHE A 104
ILE A 103
GLY A 102
VAL A  72
 None
 1.01A 3fpjA-3czpA:
undetectable		 3fpjA-3czpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		5 ILE A  41
VAL A  43
ILE A 102
ALA A  40
VAL A  69
 None
 0.91A 3fpjA-3daqA:
undetectable		 3fpjA-3daqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dp9 MTA/SAH NUCLEOSIDASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 ILE A   3
GLY A   4
VAL A  70
ILE A 179
VAL A 227
 None
 0.85A 3fpjA-3dp9A:
undetectable		 3fpjA-3dp9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg0 KLEBSIELLA
PNEUMONIAE BLRP1

(Klebsiella
pneumoniae) 		PF00563
(EAL)
PF04940
(BLUF) 		5 GLN A 379
ILE A 271
VAL A 273
ALA A 237
ARG A 293
 None
 1.00A 3fpjA-3gg0A:
undetectable		 3fpjA-3gg0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE

(Brucella
melitensis) 		PF02569
(Pantoate_ligase) 		5 ILE A  24
GLY A  25
VAL A  50
ALA A 143
VAL A 139
 None
 0.94A 3fpjA-3innA:
undetectable		 3fpjA-3innA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		6 PHE A 404
ILE A 405
GLY A 406
ILE A 436
ALA A 429
VAL A 414
 None
 1.29A 3fpjA-3lq1A:
undetectable		 3fpjA-3lq1A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nek NITROGEN
REPRESSOR-LIKE
PROTEIN MJ0159

(Methanocaldococcus
jannaschii) 		PF01995
(DUF128) 		5 PHE A 427
ILE A 417
GLY A 416
ALA A 456
VAL A 448
 None
 0.90A 3fpjA-3nekA:
undetectable		 3fpjA-3nekA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		11 GLN A  81
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ILE A 158
ALA A 195
LEU A 197
ARG A 203
VAL A 204
 3O3  A   1 ( 4.8A)
BR  A 298 ( 4.8A)
None
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
None
 0.36A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		9 MET A  78
PHE A 128
ILE A 129
GLY A 130
VAL A 152
ILE A 154
ALA A 195
LEU A 197
VAL A 204
 None
BR  A 298 ( 4.8A)
None
None
None
None
3O3  A   1 (-3.5A)
3O3  A   1 (-4.2A)
None
 1.03A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4v MTA/SAH NUCLEOSIDASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		6 ILE A   3
GLY A   4
VAL A  70
ILE A 178
ALA A  44
LEU A  45
 None
 1.37A 3fpjA-3o4vA:
undetectable		 3fpjA-3o4vA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)

(Shewanella sp.
W3-18-1) 		PF01717
(Meth_synt_2) 		5 ILE A 204
GLY A 203
VAL A 199
ILE A 148
ALA A 205
 None
 1.02A 3fpjA-3rpdA:
undetectable		 3fpjA-3rpdA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 PHE A 225
ILE A 226
GLY A 227
VAL A 242
ALA A 209
 None
 0.69A 3fpjA-3t57A:
undetectable		 3fpjA-3t57A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue1 PENICILLIN-BINDING
PROTEIN 1A

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase)
PF00912
(Transgly)
PF17092
(PCB_OB) 		5 GLY A 287
VAL A 284
ILE A 717
ALA A 290
VAL A 394
 None
 0.98A 3fpjA-3ue1A:
undetectable		 3fpjA-3ue1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 493
GLY A 492
VAL A 524
ALA A 495
VAL A 515
 None
 0.88A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk8 CADMIUM-SPECIFIC
CARBONIC ANHYDRASE

(Conticribra
weissflogii) 		no annotation 5 ILE A 493
GLY A 492
VAL A 524
ILE A 470
VAL A 515
 None
 0.86A 3fpjA-3uk8A:
undetectable		 3fpjA-3uk8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apm APICAL MEMBRANE
ANTIGEN 1

(Babesia
divergens) 		PF02430
(AMA-1) 		5 PHE A 314
ILE A 313
ILE A 425
ILE A 450
ALA A 431
 None
 1.00A 3fpjA-4apmA:
undetectable		 3fpjA-4apmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 179
GLY A 180
VAL A 192
ILE A 189
ALA A 176
 EDO  A 642 ( 3.7A)
None
None
None
EDO  A 642 (-4.1A)
 1.02A 3fpjA-4bjpA:
undetectable		 3fpjA-4bjpA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 ILE P 478
ILE P 523
ILE P 395
ALA P 481
VAL P 509
 None
 1.02A 3fpjA-4crmP:
undetectable		 3fpjA-4crmP:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 143
ILE A 157
VAL A 140
ILE A 136
ALA A 160
 None
 0.87A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4du6 GTP CYCLOHYDROLASE 1

(Yersinia pestis) 		PF01227
(GTP_cyclohydroI) 		5 PHE A 143
VAL A 140
ILE A 136
ALA A 160
VAL A 170
 None
 1.01A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g68 ABC TRANSPORTER

(Caldanaerobius) 		PF01547
(SBP_bac_1) 		5 ILE B 302
GLY B 303
VAL B 375
ILE B 380
ALA B 140
 None
 0.93A 3fpjA-4g68B:
undetectable		 3fpjA-4g68B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcm THIOREDOXIN
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		6 PHE A 273
ILE A 272
GLY A 271
VAL A 269
ALA A 106
VAL A  86
 None
 1.29A 3fpjA-4gcmA:
undetectable		 3fpjA-4gcmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn3 LMO1757 PROTEIN

(Listeria
monocytogenes) 		PF07537
(CamS) 		5 ILE A 220
ILE A 162
ALA A 165
LEU A 144
VAL A 203
 None
 0.99A 3fpjA-4hn3A:
undetectable		 3fpjA-4hn3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME

(Escherichia
virus T4;
Aquifex
aeolicus) 		PF00902
(TatC) 		5 ILE A 162
GLY A 161
VAL A 158
ILE A  74
LEU A 110
 None
 1.01A 3fpjA-4httA:
undetectable		 3fpjA-4httA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i59 CYCLOHEXYLAMINE
OXIDASE

(Microbacterium
oxydans) 		PF01593
(Amino_oxidase) 		5 ILE A  37
GLY A  38
VAL A  60
ILE A  66
ALA A 290
 FAD  A 501 (-4.7A)
FAD  A 501 (-3.2A)
None
None
None
 0.90A 3fpjA-4i59A:
undetectable		 3fpjA-4i59A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j91 KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
ADP  A 601 (-3.4A)
None
ADP  A 601 (-3.9A)
None
 0.65A 3fpjA-4j91A:
5.9		 3fpjA-4j91A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lds BICYCLOMYCIN
RESISTANCE PROTEIN
TCAB

(Staphylococcus
epidermidis) 		PF00083
(Sugar_tr) 		5 ILE A 315
GLY A 313
ILE A 350
ALA A 316
LEU A 343
 None
 0.82A 3fpjA-4ldsA:
undetectable		 3fpjA-4ldsA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		5 GLY A  20
VAL A  42
ILE A  44
ALA A 331
VAL A 340
 FDA  A 801 (-3.4A)
None
FDA  A 801 (-3.7A)
None
None
 0.62A 3fpjA-4mifA:
2.7		 3fpjA-4mifA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		5 ILE A 160
GLY A 159
VAL A 156
ILE A  43
VAL A 180
 None
 0.85A 3fpjA-4o1jA:
undetectable		 3fpjA-4o1jA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 ILE A 317
GLY A 298
ILE A 221
ILE A 255
VAL A 379
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 PHE A 296
ILE A 297
GLY A 298
VAL A 315
ALA A 222
 None
 0.76A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		5 PHE A 296
ILE A 297
GLY A 298
VAL A 315
VAL A 241
 None
 1.02A 3fpjA-4rapA:
undetectable		 3fpjA-4rapA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		5 GLY A 206
VAL A   5
ILE A   2
ALA A 186
LEU A 185
 None
 0.92A 3fpjA-4u9pA:
undetectable		 3fpjA-4u9pA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 ILE A 126
VAL A 239
ILE A 228
ALA A 129
VAL A 138
 None
ADN  A 301 ( 4.2A)
ADN  A 301 (-3.8A)
None
None
 0.96A 3fpjA-4x3mA:
undetectable		 3fpjA-4x3mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A  12
GLY A  13
VAL A  35
ILE A  37
ALA A  77
 None
 0.66A 3fpjA-5butA:
6.6		 3fpjA-5butA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5but KTR SYSTEM POTASSIUM
UPTAKE PROTEIN A,KTR
SYSTEM POTASSIUM
UPTAKE PROTEIN A

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		5 ILE A 154
GLY A 155
VAL A 177
ILE A 179
ALA A 219
 None
 0.66A 3fpjA-5butA:
6.6		 3fpjA-5butA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA
OXALATE
OXIDOREDUCTASE
SUBUNIT BETA

(Moorella
thermoacetica;
Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR)
PF02775
(TPP_enzyme_C) 		5 ILE C   5
VAL C 201
ILE B 269
ILE C 197
ALA C  39
 None
 0.99A 3fpjA-5exeC:
2.5		 3fpjA-5exeC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		5 ILE M  41
ILE M  50
ILE M 225
ALA M  53
LEU M 221
 None
 0.95A 3fpjA-5fmgM:
undetectable		 3fpjA-5fmgM:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz4 SNAKE VENOM
PHOSPHODIESTERASE
(PDE)

(Naja atra) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 ILE A 494
GLY A 195
ILE A 192
ILE A 235
VAL A 180
 None
 0.90A 3fpjA-5gz4A:
undetectable		 3fpjA-5gz4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Oryza sativa) 		no annotation 5 GLY B 317
VAL B 315
ILE B 313
ALA B 320
LEU B 282
 None
 1.00A 3fpjA-5hzgB:
undetectable		 3fpjA-5hzgB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		5 GLN A  37
ILE A 415
VAL A 460
ILE A 458
ALA A 399
 None
 0.98A 3fpjA-5k0tA:
undetectable		 3fpjA-5k0tA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 VAL A 420
ILE A 424
ILE A 426
ALA A 307
LEU A 304
 None
 0.96A 3fpjA-5k3jA:
undetectable		 3fpjA-5k3jA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		5 ILE A 230
GLY A 231
VAL A 178
LEU A 268
VAL A 218
 None
 0.97A 3fpjA-5lgxA:
undetectable		 3fpjA-5lgxA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		5 PHE A  34
ILE A  33
GLY A  32
VAL A  46
ALA A   7
 None
 0.99A 3fpjA-5loaA:
3.2		 3fpjA-5loaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A

(Methanothermococcus
thermolithotrophicus) 		PF07992
(Pyr_redox_2)
PF13187
(Fer4_9) 		5 ILE A 149
GLY A 150
VAL A 172
ALA A 327
VAL A 504
 FAD  A 701 (-4.9A)
FAD  A 701 (-3.2A)
None
None
None
 0.46A 3fpjA-5odrA:
undetectable		 3fpjA-5odrA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3j INOSITOL
MONOPHOSPHATASE

(Medicago
truncatula) 		PF00459
(Inositol_P) 		6 ILE A 165
GLY A 176
ILE A 178
ILE A 278
ALA A 166
LEU A 272
 None
 1.41A 3fpjA-5t3jA:
undetectable		 3fpjA-5t3jA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 ILE A 168
ILE A 173
ILE A 133
LEU A 232
VAL A 155
 None
 1.02A 3fpjA-5turA:
undetectable		 3fpjA-5turA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue1 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ILE A   3
GLY A   4
VAL A  70
ILE A 179
VAL A 227
 None
 0.86A 3fpjA-5ue1A:
undetectable		 3fpjA-5ue1A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		5 ILE A 123
GLY A 124
VAL A 172
ILE A 169
ALA A 210
 None
 1.00A 3fpjA-5vmkA:
undetectable		 3fpjA-5vmkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0h SPLICING FACTOR U2AF
65 KDA SUBUNIT

(Homo sapiens) 		no annotation 5 PHE A 262
ILE A 263
GLY A 264
VAL A 332
VAL A 275
 None
 0.93A 3fpjA-5w0hA:
undetectable		 3fpjA-5w0hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl7 ENGINEERED CHALCONE
ISOMERASE ANCCHI*

(unidentified) 		no annotation 5 ILE A  48
GLY A  49
VAL A  93
ILE A  17
ALA A  31
 None
None
CL  A 302 (-4.6A)
None
None
 0.99A 3fpjA-5wl7A:
undetectable		 3fpjA-5wl7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 5 ILE A 103
GLY A  85
ILE A  30
LEU A  91
VAL A 101
 None
 0.99A 3fpjA-5x4jA:
undetectable		 3fpjA-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvi GLUTAMATE
DEHYDROGENASE

(Aspergillus
niger) 		no annotation 5 MET A 208
ILE A 443
GLY A 440
ALA A 423
LEU A 420
 None
 0.97A 3fpjA-5xviA:
3.4		 3fpjA-5xviA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y51 -

(-) 		no annotation 5 ILE A 192
GLY A  97
VAL A  95
ILE A   6
LEU A 195
 None
 1.00A 3fpjA-5y51A:
undetectable		 3fpjA-5y51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 ILE A  56
GLY A  57
ILE A 350
ALA A  86
VAL A  72
 None
 1.02A 3fpjA-6bj9A:
undetectable		 3fpjA-6bj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f2t -

(-) 		no annotation 5 ILE A 515
GLY A 216
ILE A 213
ILE A 256
VAL A 201
 None
 0.92A 3fpjA-6f2tA:
undetectable		 3fpjA-6f2tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		5 ILE B1071
GLY B1074
VAL B1070
ALA A1088
VAL A1411
 None
 1.00A 3fpjA-6f42B:
undetectable		 3fpjA-6f42B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max) 		PF00190
(Cupin_1) 		4 GLY A  77
THR A  54
GLU A 119
GLU A 411
 None
 1.05A 3fpjA-1fxzA:
undetectable		 3fpjA-1fxzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 GLY A 170
THR A 454
GLU A 168
GLU A 387
 None
 1.02A 3fpjA-1gqjA:
undetectable		 3fpjA-1gqjA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 TYR A 108
GLY A 242
THR A 107
GLU A 245
 None
 0.89A 3fpjA-1h3eA:
2.7		 3fpjA-1h3eA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ile ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 382
GLY A 314
THR A 229
GLU A 261
 None
 1.07A 3fpjA-1ileA:
undetectable		 3fpjA-1ileA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 TYR A 184
GLY A 153
THR A 159
GLU A 240
 None
 0.96A 3fpjA-1iq0A:
undetectable		 3fpjA-1iq0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 GLY A  57
THR A 158
GLU A  60
GLU A  66
 None
 0.72A 3fpjA-1ir6A:
3.1		 3fpjA-1ir6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqq ALPHA-D-GLUCURONIDAS
E

(Geobacillus
stearothermophilus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 GLY A 160
THR A 453
GLU A 158
GLU A 386
 None
None
GCU  A 701 (-3.5A)
None
 0.98A 3fpjA-1mqqA:
undetectable		 3fpjA-1mqqA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 TYR Q  97
GLY Q 109
GLU Q 394
GLU Q 439
 None
 1.07A 3fpjA-1oh2Q:
undetectable		 3fpjA-1oh2Q:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn3 GLYCOSYLTRANSFERASE
GTFA

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 TYR A 121
GLY A   9
THR A  98
GLU A  77
 None
 0.88A 3fpjA-1pn3A:
3.9		 3fpjA-1pn3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
MEDIUM SUBUNIT

(Pseudomonas
putida) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 GLY C 154
THR C 149
GLU C 218
GLU C 252
 None
 0.99A 3fpjA-1t3qC:
undetectable		 3fpjA-1t3qC:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 164
THR A 159
GLU A 186
GLU A 181
 None
 1.02A 3fpjA-1ulzA:
3.3		 3fpjA-1ulzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLY A 224
THR A 259
GLU A 225
GLU A 249
 None
 0.93A 3fpjA-1ulzA:
3.3		 3fpjA-1ulzA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 TYR A 156
GLY A 198
THR A 151
GLU A 226
 None
 1.05A 3fpjA-1vefA:
2.9		 3fpjA-1vefA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR

(Solanum
lycopersicum;
Actinidia
chinensis) 		PF01095
(Pectinesterase)
PF04043
(PMEI) 		4 TYR A 135
GLY B 112
GLU B 136
GLU A 225
 None
 1.05A 3fpjA-1xg2A:
undetectable		 3fpjA-1xg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8p DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Homo sapiens) 		PF00364
(Biotin_lipoyl) 		4 GLY B 147
THR B 202
GLU B 170
GLU B 153
 None
 1.08A 3fpjA-1y8pB:
undetectable		 3fpjA-1y8pB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yob FLAVODOXIN 2

(Azotobacter
vinelandii) 		PF00258
(Flavodoxin_1) 		4 GLY A  64
THR A  54
GLU A  76
GLU A  82
 None
 0.93A 3fpjA-1yobA:
undetectable		 3fpjA-1yobA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxk CADHERIN-8

(Mus musculus) 		PF00028
(Cadherin) 		4 GLY A  41
THR A  46
GLU A  91
GLU A  70
 None
 1.08A 3fpjA-1zxkA:
undetectable		 3fpjA-1zxkA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bz0 GTP CYCLOHYDROLASE
II

(Escherichia
coli) 		PF00925
(GTP_cyclohydro2) 		4 GLY A  93
THR A 114
GLU A  92
GLU A  53
 G2P  A1176 (-3.4A)
G2P  A1176 (-2.9A)
G2P  A1176 (-4.3A)
None
 0.99A 3fpjA-2bz0A:
undetectable		 3fpjA-2bz0A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 TYR A   3
GLY A  47
GLU A  48
GLU A  57
 None
 0.76A 3fpjA-2cfmA:
undetectable		 3fpjA-2cfmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3i OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 TYR A  92
GLY A  62
GLU A  66
GLU A 149
 AL  A 687 ( 4.1A)
None
None
None
 1.00A 3fpjA-2d3iA:
undetectable		 3fpjA-2d3iA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d9x OXYSTEROL BINDING
PROTEIN-RELATED
PROTEIN 11

(Homo sapiens) 		PF00169
(PH) 		4 GLY A  36
THR A 107
GLU A  39
GLU A  80
 None
 1.05A 3fpjA-2d9xA:
undetectable		 3fpjA-2d9xA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 TYR A 443
THR A 289
GLU A 367
GLU A 241
 None
 1.06A 3fpjA-2ehqA:
4.9		 3fpjA-2ehqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		4 GLY B 579
THR B 563
GLU A 332
GLU A 369
 None
 1.05A 3fpjA-2pjrB:
undetectable		 3fpjA-2pjrB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		4 TYR A 701
GLY A 712
THR A 668
GLU A 754
 None
 0.98A 3fpjA-2x2iA:
undetectable		 3fpjA-2x2iA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 100
THR A  79
GLU A  97
GLU A 334
 None
 1.07A 3fpjA-2x40A:
2.9		 3fpjA-2x40A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE

(Leishmania
infantum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 TYR A 110
GLY A  15
GLU A 341
GLU A 347
 None
FAD  A1487 (-4.0A)
None
None
 1.09A 3fpjA-2x50A:
2.5		 3fpjA-2x50A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 TYR A  18
GLY A 138
THR A  20
GLU A 110
 None
SF4  A 602 (-3.6A)
None
None
 0.90A 3fpjA-2xdqA:
undetectable		 3fpjA-2xdqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		4 TYR A 106
GLY A 155
THR A  93
GLU A 169
 None
 0.94A 3fpjA-2xtzA:
undetectable		 3fpjA-2xtzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfs LEVANSUCRASE

(Lactobacillus
johnsonii) 		PF02435
(Glyco_hydro_68) 		4 GLY A 584
THR A 541
GLU A 582
GLU A 234
 None
 0.89A 3fpjA-2yfsA:
undetectable		 3fpjA-2yfsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abb CYTOCHROME P450
HYDROXYLASE

(Streptomyces
avermitilis) 		PF00067
(p450) 		4 GLY A 396
THR A 258
GLU A 246
GLU A 362
 None
None
None
HEM  A1430 ( 4.7A)
 1.05A 3fpjA-3abbA:
undetectable		 3fpjA-3abbA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		4 TYR A 191
GLY A 162
THR A 189
GLU A 172
 None
 1.03A 3fpjA-3aqiA:
undetectable		 3fpjA-3aqiA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc1 PUTATIVE
ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bacillus
halodurans) 		PF16499
(Melibiase_2) 		4 TYR A  21
GLY A  32
THR A  26
GLU A  35
 None
 0.97A 3fpjA-3cc1A:
undetectable		 3fpjA-3cc1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 GLY A 574
THR A 549
GLU A 227
GLU A 288
 None
None
None
GOL  A 826 (-3.7A)
 0.74A 3fpjA-3cf4A:
undetectable		 3fpjA-3cf4A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLY A 617
THR A 606
GLU A 235
GLU A  41
 None
 1.04A 3fpjA-3cihA:
undetectable		 3fpjA-3cihA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnk CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 TYR A  11
GLY A 118
THR A  13
GLU A  74
 None
 0.97A 3fpjA-3fnkA:
undetectable		 3fpjA-3fnkA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghp CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 TYR A  11
GLY A 118
THR A  13
GLU A  74
 None
 0.79A 3fpjA-3ghpA:
undetectable		 3fpjA-3ghpA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gms PUTATIVE
NADPH:QUINONE
REDUCTASE

(Bacillus
thuringiensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 TYR A 330
GLY A  68
THR A 328
GLU A  67
 None
 1.02A 3fpjA-3gmsA:
5.6		 3fpjA-3gmsA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grd UNCHARACTERIZED
NTF2-SUPERFAMILY
PROTEIN

(Bacillus cereus) 		PF12680
(SnoaL_2) 		4 TYR A  13
THR A  12
GLU A  33
GLU A 111
 None
 1.05A 3fpjA-3grdA:
undetectable		 3fpjA-3grdA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 TYR A 121
GLY A   9
THR A  98
GLU A  77
 None
 0.87A 3fpjA-3h4iA:
3.6		 3fpjA-3h4iA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 GLY A  66
THR A  95
GLU A  64
GLU A  85
 None
 1.02A 3fpjA-3hn2A:
4.7		 3fpjA-3hn2A:
27.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho6 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80) 		4 GLY A 157
THR A 109
GLU A 203
GLU A 213
 None
 0.95A 3fpjA-3ho6A:
undetectable		 3fpjA-3ho6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima) 		PF00154
(RecA) 		4 GLY A  54
THR A  44
GLU A  33
GLU A 283
 None
 0.98A 3fpjA-3hr8A:
undetectable		 3fpjA-3hr8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		4 TYR A 414
GLY A 355
THR A 350
GLU A 249
 None
 1.00A 3fpjA-3hrpA:
undetectable		 3fpjA-3hrpA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilk UNCHARACTERIZED
TRNA/RRNA
METHYLTRANSFERASE
HI0380

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		4 TYR A 191
GLY A 225
THR A 187
GLU A 216
 None
 0.88A 3fpjA-3ilkA:
undetectable		 3fpjA-3ilkA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isy INTRACELLULAR
PROTEINASE INHIBITOR

(Bacillus
subtilis) 		PF12690
(BsuPI) 		4 GLY A 102
THR A  99
GLU A  34
GLU A   5
 None
 1.03A 3fpjA-3isyA:
undetectable		 3fpjA-3isyA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j8g GTPASE DER

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF14714
(KH_dom-like) 		4 TYR X 415
THR X 376
GLU X 283
GLU X 246
 None
 1.05A 3fpjA-3j8gX:
undetectable		 3fpjA-3j8gX:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k0s DNA MISMATCH REPAIR
PROTEIN MUTS

(Escherichia
coli) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLY A  87
THR A 118
GLU A  88
GLU A  26
 None
 1.07A 3fpjA-3k0sA:
undetectable		 3fpjA-3k0sA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5w CARBOHYDRATE KINASE

(Helicobacter
pylori) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		4 GLY A 243
GLU A 270
GLU A 302
GLU A 328
 None
 0.80A 3fpjA-3k5wA:
3.6		 3fpjA-3k5wA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 TYR A 328
GLY A 455
THR A 172
GLU A 469
 None
 1.07A 3fpjA-3kalA:
undetectable		 3fpjA-3kalA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 TYR B 319
GLY B 180
GLU B 142
GLU B 140
 None
 1.07A 3fpjA-3kdjB:
undetectable		 3fpjA-3kdjB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 TYR B 319
GLY B 181
GLU B 142
GLU B 140
 None
 1.06A 3fpjA-3kdjB:
undetectable		 3fpjA-3kdjB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8q CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 TYR A 174
GLY A 281
THR A 176
GLU A 237
 None
 0.88A 3fpjA-3l8qA:
undetectable		 3fpjA-3l8qA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcu DIPICOLINATE
SYNTHASE, B CHAIN

(Bacillus cereus) 		PF02441
(Flavoprotein) 		4 GLY A 156
THR A 130
GLU A 193
GLU A 161
 None
 0.89A 3fpjA-3mcuA:
3.8		 3fpjA-3mcuA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLY A 190
THR A 363
GLU A 380
GLU A 388
 None
 0.98A 3fpjA-3mruA:
undetectable		 3fpjA-3mruA:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		6 TYR A 107
GLY A 132
THR A 137
GLU A 153
GLU A 155
GLU A 181
 3O3  A   1 (-3.8A)
None
BR  A 298 (-4.0A)
None
None
None
 0.58A 3fpjA-3o31A:
42.7		 3fpjA-3o31A:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		4 TYR A 175
GLY A 213
GLU A 186
GLU A 242
 F9F  A   1 (-4.0A)
F9F  A   1 (-3.6A)
None
None
 0.93A 3fpjA-3pr2A:
undetectable		 3fpjA-3pr2A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u37 ACETYL-XYLAN
ESTERASE EST2A

(Butyrivibrio
proteoclasticus) 		PF13472
(Lipase_GDSL_2) 		4 GLY A 223
THR A  23
GLU A 221
GLU A  53
 None
 0.88A 3fpjA-3u37A:
2.8		 3fpjA-3u37A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyw MNMC2

(Aquifex
aeolicus) 		PF05430
(Methyltransf_30) 		4 GLY A 106
GLU A 133
GLU A 135
GLU A 202
 SAM  A 501 (-3.3A)
SAM  A 501 (-2.3A)
None
SAM  A 501 (-4.2A)
 0.92A 3fpjA-3vywA:
5.5		 3fpjA-3vywA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 GLY A 134
THR A 139
GLU A 118
GLU A 215
 None
None
ADP  A1364 (-3.8A)
None
 1.09A 3fpjA-3zcwA:
undetectable		 3fpjA-3zcwA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 TYR A 190
GLY A 267
THR A 270
GLU A 265
 None
 1.05A 3fpjA-4a73A:
4.0		 3fpjA-4a73A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqb MANNAN-BINDING
LECTIN SERINE
PROTEASE 1

(Homo sapiens) 		PF00084
(Sushi)
PF00431
(CUB)
PF14670
(FXa_inhibition) 		4 TYR A  40
GLY A  92
THR A 129
GLU A  99
 None
 1.08A 3fpjA-4aqbA:
undetectable		 3fpjA-4aqbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 GLY A 107
GLU A 153
GLU A 150
GLU A  32
 F1P  A 702 (-4.3A)
F1P  A 702 (-3.3A)
None
None
 1.04A 3fpjA-4bb9A:
3.3		 3fpjA-4bb9A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfc 3-DEOXY-D-MANNO-OCTU
LOSONIC-ACID
TRANSFERASE

(Acinetobacter
baumannii) 		no annotation 4 TYR A 321
GLY A 330
THR A 241
GLU A 249
 None
 1.07A 3fpjA-4bfcA:
4.7		 3fpjA-4bfcA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bma UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Aspergillus
fumigatus) 		PF01704
(UDPGP) 		4 TYR A 361
GLY A 250
GLU A 407
GLU A 329
 None
 1.04A 3fpjA-4bmaA:
undetectable		 3fpjA-4bmaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyt UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF03695
(UPF0149) 		4 GLY A 113
THR A 119
GLU A  31
GLU A 109
 None
 0.97A 3fpjA-4gytA:
undetectable		 3fpjA-4gytA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		4 GLY A 143
THR A 269
GLU A 304
GLU A 326
 None
 1.09A 3fpjA-4hdtA:
undetectable		 3fpjA-4hdtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hes BETA-LACTAMASE CLASS
A-LIKE PROTEIN

(Veillonella
parvula) 		PF13354
(Beta-lactamase2) 		4 GLY A 130
THR A 122
GLU A 132
GLU A 147
 None
 1.05A 3fpjA-4hesA:
undetectable		 3fpjA-4hesA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k49 ESTERASE YDII

(Escherichia
coli) 		no annotation 4 GLY C  96
THR C  46
GLU C 121
GLU C  37
 None
 0.90A 3fpjA-4k49C:
undetectable		 3fpjA-4k49C:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k4d PROOFREADING
THIOESTERASE ENTH

(Escherichia
coli) 		PF03061
(4HBT) 		4 GLY A  96
THR A  46
GLU A 121
GLU A  37
 None
 0.99A 3fpjA-4k4dA:
undetectable		 3fpjA-4k4dA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		4 GLY A 100
THR A  21
GLU A  27
GLU A 162
 None
 1.07A 3fpjA-4p5pA:
2.8		 3fpjA-4p5pA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 GLY A 253
THR A 372
GLU A 285
GLU A 335
 None
 1.05A 3fpjA-4r16A:
5.7		 3fpjA-4r16A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		4 GLY A  10
THR A 107
GLU A  22
GLU A  29
 None
None
None
GOL  A 201 (-3.5A)
 1.04A 3fpjA-4ra6A:
undetectable		 3fpjA-4ra6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 GLY A  66
THR A  88
GLU A  12
GLU A  14
 None
SO4  A 403 (-2.8A)
None
None
 1.07A 3fpjA-4rh0A:
undetectable		 3fpjA-4rh0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4to8 FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE,
CLASS II

(Staphylococcus
aureus) 		PF01116
(F_bP_aldolase) 		4 GLY A 274
THR A 281
GLU A 270
GLU A  36
 None
 0.92A 3fpjA-4to8A:
undetectable		 3fpjA-4to8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wi0 CELLULOSOMAL
SCAFFOLDIN ADAPTOR
PROTEIN B

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 TYR A   4
GLY A 111
THR A   6
GLU A  67
 None
 0.97A 3fpjA-4wi0A:
undetectable		 3fpjA-4wi0A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbk DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Lactobacillus
brevis) 		PF01791
(DeoC) 		4 GLY A  67
THR A 161
GLU A  78
GLU A 101
 None
 1.08A 3fpjA-4xbkA:
undetectable		 3fpjA-4xbkA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 TYR A  40
GLY A  62
THR A  43
GLU A  54
 None
None
None
SO4  A 902 (-4.5A)
 1.02A 3fpjA-4xriA:
undetectable		 3fpjA-4xriA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris) 		PF13462
(Thioredoxin_4) 		4 TYR A 134
GLY A 275
THR A 270
GLU A 276
 None
 0.96A 3fpjA-4z7xA:
undetectable		 3fpjA-4z7xA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zps MCG133388, ISOFORM
CRA_M

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 TYR A 250
GLY A 246
THR A 249
GLU A 242
 None
CA  A 805 ( 4.8A)
None
None
 1.00A 3fpjA-4zpsA:
undetectable		 3fpjA-4zpsA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsx UNCHARACTERIZED
FUSION PROTEIN

(Pseudomonas
aeruginosa;
Aquifex
aeolicus) 		PF06557
(DUF1122) 		4 TYR A 101
GLY A 114
THR A 107
GLU A 174
 None
 1.00A 3fpjA-4zsxA:
undetectable		 3fpjA-4zsxA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 TYR A 369
GLY A 189
THR A 136
GLU A 185
 None
 1.04A 3fpjA-5a7mA:
2.9		 3fpjA-5a7mA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 TYR A 500
GLY A 469
GLU A 470
GLU A 198
GLU A 180
 None
 1.35A 3fpjA-5f7sA:
undetectable		 3fpjA-5f7sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLY A 254
THR A 333
GLU A 213
GLU A 361
 None
None
NAG  A1357 (-3.9A)
None
 0.94A 3fpjA-5fkcA:
undetectable		 3fpjA-5fkcA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwh ESSC

(Geobacillus
thermodenitrificans) 		PF12538
(FtsK_SpoIIIE_N) 		4 TYR A   8
GLY A  27
GLU A  31
GLU A  21
 None
 1.09A 3fpjA-5fwhA:
undetectable		 3fpjA-5fwhA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjn LYSINE/ORNITHINE
DECARBOXYLASE

(Selenomonas
ruminantium) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A 350
THR A  55
GLU A 348
GLU A  32
 None
 0.90A 3fpjA-5gjnA:
undetectable		 3fpjA-5gjnA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkx UNCHARACTERIZED
PROTEIN

(Thermococcus
onnurineus) 		PF14336
(DUF4392) 		4 GLY A 236
THR A 240
GLU A  59
GLU A 115
 None
 0.84A 3fpjA-5gkxA:
3.4		 3fpjA-5gkxA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		4 GLY A 197
THR A 201
GLU A 216
GLU A 218
 SAM  A 301 (-3.4A)
None
SAM  A 301 (-3.1A)
None
 0.81A 3fpjA-5hfjA:
2.7		 3fpjA-5hfjA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		4 TYR A  91
GLY A  13
THR A  71
GLU A  46
 None
 1.02A 3fpjA-5htpA:
undetectable		 3fpjA-5htpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 GLY S 422
THR S 426
GLU S 452
GLU S 379
 None
 1.02A 3fpjA-5k0yS:
undetectable		 3fpjA-5k0yS:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 197
GLY A 173
THR A 194
GLU A 178
 None
 0.93A 3fpjA-5karA:
undetectable		 3fpjA-5karA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 GLY A 111
THR A  38
GLU A 109
GLU A 102
 None
 1.05A 3fpjA-5ktkA:
5.2		 3fpjA-5ktkA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT
POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		PF03814
(KdpA)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
PF02669
(KdpC) 		4 TYR B 599
GLY A 452
GLU A 455
GLU C  93
 None
 0.88A 3fpjA-5mrwB:
3.1		 3fpjA-5mrwB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 4 TYR A 119
GLY A  91
THR A 130
GLU A  84
 None
 0.96A 3fpjA-5onuA:
undetectable		 3fpjA-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syq UNCHARACTERIZED
PROTEIN AQ_1974

(Aquifex
aeolicus) 		no annotation 4 GLY A  83
THR A  67
GLU A  85
GLU A  77
 None
 1.02A 3fpjA-5syqA:
undetectable		 3fpjA-5syqA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqr POLYCOMB PROTEIN EED

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 TYR A 188
GLY A 140
THR A 161
GLU A 117
 None
 1.07A 3fpjA-5tqrA:
undetectable		 3fpjA-5tqrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCD

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 GLY B  86
THR B 118
GLU B  87
GLU B  98
 None
 0.91A 3fpjA-5vipB:
undetectable		 3fpjA-5vipB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 4 GLY A 453
GLU A 454
GLU A 189
GLU A 171
 None
None
GLC  A 819 ( 2.8A)
None
 0.99A 3fpjA-5x3jA:
undetectable		 3fpjA-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 GLY A 424
THR A 443
GLU A 426
GLU A 431
 None
 0.95A 3fpjA-6b6lA:
undetectable		 3fpjA-6b6lA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqw BACTERIAL ACTIN ALFA

(Bacillus
subtilis) 		no annotation 4 TYR A 255
GLY A  27
GLU A  98
GLU A  46
 ANP  A 301 (-3.4A)
None
None
None
 1.00A 3fpjA-6bqwA:
undetectable		 3fpjA-6bqwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 4 GLY C 312
THR C 315
GLU C 254
GLU C 102
 None
 1.08A 3fpjA-6fkhC:
2.6		 3fpjA-6fkhC:
undetectable