SIMILAR PATTERNS OF AMINO ACIDS FOR 3FL9_F_TOPF200

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9w HEMOGLOBIN (BETA
CHAIN)


(Homo sapiens)
PF00042
(Globin)
5 LEU E 114
VAL E 134
ALA E  23
LEU E 106
PHE E  71
None
None
None
HEM  E 147 (-4.3A)
HEM  E 147 ( 4.7A)
1.17A 3fl9F-1a9wE:
undetectable
3fl9F-1a9wE:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cij PROTEIN (HALOALKANE
DEHALOGENASE)


(Xanthobacter
autotrophicus)
PF00561
(Abhydrolase_1)
5 ALA A 149
LEU A 131
ALA A 240
ILE A 241
PHE A 161
None
1.02A 3fl9F-1cijA:
undetectable
3fl9F-1cijA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos)
PF00206
(Lyase_1)
PF14698
(ASL_C2)
5 LEU A 123
VAL A 338
ILE A 196
LEU A 131
PHE A 244
None
1.10A 3fl9F-1dcnA:
undetectable
3fl9F-1dcnA:
16.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dr6 DIHYDROFOLATE
REDUCTASE


(Gallus gallus)
PF00186
(DHFR_1)
5 ALA A   9
ASN A  21
LEU A  22
GLU A  30
LEU A  67
HBI  A 198 ( 3.6A)
None
NAP  A 191 ( 4.7A)
HBI  A 198 (-3.0A)
None
0.97A 3fl9F-1dr6A:
20.4
3fl9F-1dr6A:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE


(Escherichia
coli)
PF00378
(ECH_1)
5 ALA A 111
VAL A 103
ILE A 177
LEU A 178
PHE A 129
None
1.21A 3fl9F-1ef9A:
undetectable
3fl9F-1ef9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE


(Salmonella
enterica)
PF16363
(GDP_Man_Dehyd)
5 ALA A 106
ALA A  57
ILE A  31
LEU A   4
PHE A  69
None
1.17A 3fl9F-1g1aA:
undetectable
3fl9F-1g1aA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gmi PROTEIN KINASE C,
EPSILON TYPE


(Rattus rattus)
PF00168
(C2)
5 LEU A  44
VAL A  73
ILE A 129
LEU A 131
PHE A 102
None
1.03A 3fl9F-1gmiA:
undetectable
3fl9F-1gmiA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1


(Saccharomyces
cerevisiae)
PF00025
(Arf)
5 MET A   8
ALA A  87
ILE A  21
LEU A  64
PHE A   9
None
1.13A 3fl9F-1mozA:
undetectable
3fl9F-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1moz ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
1


(Saccharomyces
cerevisiae)
PF00025
(Arf)
6 MET A   8
LEU A 123
ALA A  88
ILE A  21
LEU A  64
PHE A   9
None
1.15A 3fl9F-1mozA:
undetectable
3fl9F-1mozA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacillus
subtilis)
PF08282
(Hydrolase_3)
5 ASN A  14
LEU A  13
VAL A  39
LEU A  27
PHE A  52
None
1.19A 3fl9F-1nrwA:
undetectable
3fl9F-1nrwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103


(Geobacillus
stearothermophilus)
PF02645
(DegV)
5 ALA A  67
LEU A  26
VAL A 101
ALA A  24
LEU A 114
None
1.08A 3fl9F-1pzxA:
undetectable
3fl9F-1pzxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103


(Geobacillus
stearothermophilus)
PF02645
(DegV)
5 ALA A  67
VAL A 101
ALA A  24
ILE A   6
LEU A 114
None
1.20A 3fl9F-1pzxA:
undetectable
3fl9F-1pzxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE


(Thermus
thermophilus)
PF16868
(NMT1_3)
5 ASN A  53
VAL A 268
ALA A  54
ILE A  23
LEU A 250
None
1.15A 3fl9F-1us4A:
undetectable
3fl9F-1us4A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT


(Saccharomyces
cerevisiae)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 LEU B 437
ALA B 501
ILE B 504
LEU B 456
PHE B 509
None
1.23A 3fl9F-1wa5B:
undetectable
3fl9F-1wa5B:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9g EXO-INULINASE

(Aspergillus
awamori)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 VAL A 525
ALA A 424
ILE A 423
LEU A 410
PHE A 421
None
1.14A 3fl9F-1y9gA:
undetectable
3fl9F-1y9gA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT


(Pyrococcus
abyssi)
PF00575
(S1)
PF07541
(EIF_2_alpha)
5 ALA A 180
LEU A 260
ALA A 258
ILE A 247
PHE A 216
None
0.96A 3fl9F-1yz6A:
undetectable
3fl9F-1yz6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz7 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT


(Pyrococcus
abyssi)
PF07541
(EIF_2_alpha)
5 ALA A 180
LEU A 260
ALA A 258
ILE A 247
PHE A 216
None
1.09A 3fl9F-1yz7A:
undetectable
3fl9F-1yz7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon)
PF07859
(Abhydrolase_3)
5 ALA A 160
VAL A 175
ALA A 300
ILE A 304
LEU A 308
None
1.04A 3fl9F-2c7bA:
undetectable
3fl9F-2c7bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE


(Archaeoglobus
fulgidus)
PF00579
(tRNA-synt_1b)
5 LEU A   7
GLU A  20
VAL A  17
ALA A  62
LEU A 173
None
1.22A 3fl9F-2cybA:
undetectable
3fl9F-2cybA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE


(Bacillus
circulans)
PF01761
(DHQ_synthase)
5 LEU A 351
VAL A 228
ILE A 190
LEU A 191
PHE A 242
None
1.11A 3fl9F-2d2xA:
undetectable
3fl9F-2d2xA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc1 L-ASPARTATE
DEHYDROGENASE


(Archaeoglobus
fulgidus)
PF01958
(DUF108)
PF03447
(NAD_binding_3)
5 ASN A 206
VAL A 177
ALA A 111
ILE A 112
LEU A 167
None
None
CIT  A1585 ( 3.1A)
None
None
1.15A 3fl9F-2dc1A:
undetectable
3fl9F-2dc1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffh PROTEIN (FFH)

(Thermus
aquaticus)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 LEU A  86
VAL A  43
ALA A 288
ILE A 291
LEU A   5
None
1.23A 3fl9F-2ffhA:
4.4
3fl9F-2ffhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 ALA A 410
LEU A 319
ILE A 306
LEU A 310
PHE A 387
None
1.15A 3fl9F-2g3nA:
undetectable
3fl9F-2g3nA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE


(Enterococcus
faecalis)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit)
5 MET A   1
ALA A 519
ILE A 522
LEU A  45
PHE A 471
None
1.03A 3fl9F-2j3mA:
undetectable
3fl9F-2j3mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00202
(Aminotran_3)
5 ALA A 256
LEU A 218
ILE A 196
LEU A 163
PHE A 235
None
0.94A 3fl9F-2jjfA:
undetectable
3fl9F-2jjfA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD


(Escherichia
coli)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
5 ALA A 189
LEU A 288
ALA A 254
ILE A 232
LEU A 304
None
None
None
NAP  A 402 ( 4.8A)
NAP  A 402 (-4.0A)
1.08A 3fl9F-2o7pA:
13.7
3fl9F-2o7pA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE


(Escherichia
virus N4)
no annotation 5 ALA A 913
VAL A 890
ALA A 321
LEU A 859
PHE A 831
None
1.09A 3fl9F-2po4A:
undetectable
3fl9F-2po4A:
10.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qk8 DIHYDROFOLATE
REDUCTASE


(Bacillus
anthracis)
PF00186
(DHFR_1)
9 MET A   6
ALA A   8
LEU A  21
GLU A  28
VAL A  32
ALA A  50
ILE A  51
LEU A  55
PHE A  96
MTX  A 200 ( 4.1A)
MTX  A 200 ( 3.4A)
MTX  A 200 ( 4.5A)
MTX  A 200 ( 2.8A)
MTX  A 200 ( 4.7A)
MTX  A 200 ( 4.0A)
MTX  A 200 ( 4.2A)
MTX  A 200 ( 4.1A)
MTX  A 200 ( 3.9A)
0.79A 3fl9F-2qk8A:
27.7
3fl9F-2qk8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
5 ALA A 229
VAL A 239
ALA A 213
ILE A 214
PHE A 235
None
1.16A 3fl9F-2qm1A:
undetectable
3fl9F-2qm1A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rvj EPITHELIAL SPLICING
REGULATORY PROTEIN 1


(Homo sapiens)
PF00076
(RRM_1)
5 ALA A 504
VAL A 520
ILE A 461
LEU A 452
PHE A 464
None
0.85A 3fl9F-2rvjA:
undetectable
3fl9F-2rvjA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfk AKAP18 DELTA

(Homo sapiens)
PF10469
(AKAP7_NLS)
5 ALA A 204
LEU A  94
VAL A 160
ILE A  96
LEU A 262
None
1.07A 3fl9F-2vfkA:
undetectable
3fl9F-2vfkA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9s DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003


(Staphylococcus
aureus)
PF00186
(DHFR_1)
5 ALA A   7
LEU A  20
ILE A  50
LEU A  54
PHE A  92
TOP  A1160 ( 3.6A)
TOP  A1160 ( 4.2A)
TOP  A1160 (-4.4A)
None
TOP  A1160 ( 3.9A)
0.76A 3fl9F-2w9sA:
24.8
3fl9F-2w9sA:
44.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)


(Archaeoglobus
fulgidus)
PF02492
(cobW)
5 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
None
1.20A 3fl9F-2wsmA:
3.6
3fl9F-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE


(Sphingomonas
wittichii)
PF00155
(Aminotran_1_2)
5 ASN A 305
LEU A 373
ILE A 385
LEU A 352
PHE A 389
None
1.11A 3fl9F-2x8uA:
2.3
3fl9F-2x8uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xty QNRB1

(Klebsiella
pneumoniae)
PF00805
(Pentapeptide)
PF13599
(Pentapeptide_4)
5 ALA A  91
ALA A 114
ILE A  84
LEU A  61
PHE A  66
None
1.23A 3fl9F-2xtyA:
undetectable
3fl9F-2xtyA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aal PROBABLE
ENDONUCLEASE 4


(Geobacillus
kaustophilus)
PF01261
(AP_endonuc_2)
5 ALA A  70
LEU A 107
ALA A 104
ILE A 102
LEU A  49
None
0.97A 3fl9F-3aalA:
undetectable
3fl9F-3aalA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C


(Sulfurisphaera
tokodaii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
5 LEU C 178
ALA C 132
ILE C 217
LEU C 227
PHE C 156
None
1.02A 3fl9F-3aizC:
undetectable
3fl9F-3aizC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq8 SENSOR PROTEIN PHOQ

(Escherichia
coli)
PF08918
(PhoQ_Sensor)
5 MET A  85
ALA A  98
LEU A  95
VAL A 102
ILE A 109
None
1.12A 3fl9F-3bq8A:
undetectable
3fl9F-3bq8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eey PUTATIVE RRNA
METHYLASE


(Ruminiclostridium
thermocellum)
PF06962
(rRNA_methylase)
5 ALA A  36
ASN A  60
VAL A  74
ALA A  57
ILE A  58
None
None
None
SAM  A 300 ( 4.3A)
None
1.17A 3fl9F-3eeyA:
2.7
3fl9F-3eeyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE


(Desulfovibrio
gigas)
PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
5 ALA A  59
VAL A  26
ALA A  71
ILE A   6
LEU A  15
None
1.10A 3fl9F-3fahA:
undetectable
3fl9F-3fahA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
5 LEU A 340
ALA A  96
ILE A  95
LEU A 214
PHE A 210
None
1.21A 3fl9F-3foaA:
undetectable
3fl9F-3foaA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdz ARGINYL-TRNA
SYNTHETASE


(Klebsiella
pneumoniae)
PF03485
(Arg_tRNA_synt_N)
5 ALA A  48
ASN A  42
ALA A  41
ILE A  83
LEU A  63
None
EDO  A 107 ( 3.2A)
None
None
None
1.08A 3fl9F-3gdzA:
undetectable
3fl9F-3gdzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1


(Clostridium
perfringens)
PF00005
(ABC_tran)
5 VAL A   8
ALA A  36
ILE A  37
LEU A  48
PHE A  52
None
1.23A 3fl9F-3gfoA:
undetectable
3fl9F-3gfoA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8a DIHYDROFOLATE
REDUCTASE


(Staphylococcus
aureus)
PF00186
(DHFR_1)
6 ALA X   7
LEU X  20
VAL X  31
ILE X  50
LEU X  54
PHE X  92
N22  X 219 ( 3.6A)
N22  X 219 ( 4.6A)
None
N22  X 219 (-4.6A)
None
N22  X 219 ( 3.7A)
0.67A 3fl9F-3i8aX:
25.0
3fl9F-3i8aX:
46.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18


(Escherichia
virus T4)
PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C)
5 LEU U 340
ALA U  96
ILE U  95
LEU U 214
PHE U 210
None
1.21A 3fl9F-3j2nU:
undetectable
3fl9F-3j2nU:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2


(Bluetongue
virus)
PF00898
(Orbi_VP2)
5 ALA A 730
ASN A 807
LEU A 806
ALA A 809
ILE A 813
None
1.04A 3fl9F-3j9dA:
undetectable
3fl9F-3j9dA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1


(Danio rerio)
PF12940
(RAG1)
5 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
None
1.14A 3fl9F-3jbyA:
undetectable
3fl9F-3jbyA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE


(Psychrobacter
arcticus)
PF00266
(Aminotran_5)
5 ALA A 158
GLU A 154
ALA A 140
ILE A 172
LEU A 182
None
1.19A 3fl9F-3ke3A:
undetectable
3fl9F-3ke3A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwt PHOSPHOINOSITIDE
PHOSPHATASE SAC1


(Saccharomyces
cerevisiae)
PF02383
(Syja_N)
5 ALA X  56
VAL X  90
ALA X  70
ILE X  71
LEU X 119
None
1.14A 3fl9F-3lwtX:
undetectable
3fl9F-3lwtX:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN

(Triatoma virus)
PF00073
(Rhv)
5 ALA B 113
LEU B 110
VAL B 236
LEU B 151
PHE B 106
None
1.01A 3fl9F-3napB:
undetectable
3fl9F-3napB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
1


(Homo sapiens)
PF16099
(RMI1_C)
5 ALA A 603
VAL A 534
ALA A 607
LEU A 588
PHE A 545
None
1.17A 3fl9F-3nbhA:
undetectable
3fl9F-3nbhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk4 ZONA PELLUCIDA 3

(Gallus gallus)
PF00100
(Zona_pellucida)
5 VAL A 226
ALA A 231
ILE A 293
LEU A 186
PHE A 276
None
1.15A 3fl9F-3nk4A:
undetectable
3fl9F-3nk4A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkx UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0893


(Haemophilus
influenzae)
PF00440
(TetR_N)
5 MET A  65
ALA A 155
ILE A 156
LEU A 105
PHE A  66
None
1.11A 3fl9F-3qkxA:
undetectable
3fl9F-3qkxA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1o ODORANT BINDING
PROTEIN, ANTENNAL


(Anopheles
gambiae)
PF01395
(PBP_GOBP)
5 LEU A 124
VAL A 107
ILE A  57
LEU A  72
PHE A  54
PLM  A 128 (-4.9A)
PLM  A 128 ( 4.7A)
PLM  A 128 ( 4.5A)
None
PLM  A 128 ( 4.9A)
1.18A 3fl9F-3r1oA:
undetectable
3fl9F-3r1oA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN


(Agrobacterium
fabrum)
PF01168
(Ala_racemase_N)
5 ALA A  92
LEU A  84
ILE A 102
LEU A 157
PHE A 124
None
1.10A 3fl9F-3r79A:
undetectable
3fl9F-3r79A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 LEU A 533
VAL A 516
ALA A 502
ILE A 499
PHE A 522
None
1.09A 3fl9F-3sunA:
undetectable
3fl9F-3sunA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfz CYCLASE

(Streptomyces
sp. R1128)
PF10604
(Polyketide_cyc2)
5 ALA A 137
ASN A  60
ALA A  83
ILE A  85
LEU A 126
None
1.23A 3fl9F-3tfzA:
undetectable
3fl9F-3tfzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thu MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN


(Sphingomonas
sp. SKA58)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  35
LEU A  48
ALA A   7
ILE A  23
LEU A  94
None
1.16A 3fl9F-3thuA:
undetectable
3fl9F-3thuA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4b STARVATION SENSING
PROTEIN RSPA


(Cellvibrio
japonicus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  34
LEU A  47
ALA A   6
ILE A  22
LEU A  93
None
1.17A 3fl9F-3v4bA:
undetectable
3fl9F-3v4bA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE


(Caulobacter
vibrioides)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  35
LEU A  48
ALA A   7
ILE A  23
LEU A  94
None
1.23A 3fl9F-3vcnA:
undetectable
3fl9F-3vcnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi)
PF02471
(OspE)
5 LEU A  75
VAL A  44
ILE A  84
LEU A 157
PHE A  20
None
1.20A 3fl9F-4bxmA:
undetectable
3fl9F-4bxmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA A 173
ALA A 154
ILE A 156
LEU A 161
PHE A 208
None
1.23A 3fl9F-4c7vA:
undetectable
3fl9F-4c7vA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d5g CYCLOHEXANE-1,2-DION
E HYDROLASE


(Azoarcus sp.
BH72)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ALA A 272
ASN A 266
ALA A 257
ILE A 287
LEU A 282
None
1.18A 3fl9F-4d5gA:
2.6
3fl9F-4d5gA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE


(Mycobacterium
avium)
PF04909
(Amidohydro_2)
5 LEU A 120
VAL A 289
ALA A 164
ILE A 163
LEU A 392
None
1.19A 3fl9F-4dziA:
undetectable
3fl9F-4dziA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Caulobacter sp.
K31)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ALA A  35
LEU A  48
ALA A   7
ILE A  23
LEU A  94
None
1.21A 3fl9F-4fi4A:
undetectable
3fl9F-4fi4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1)
PF00661
(Matrix)
5 ALA A 307
ASN A 234
ALA A 233
ILE A 210
LEU A 270
None
0.96A 3fl9F-4g1gA:
undetectable
3fl9F-4g1gA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7c AMINOPEPTIDASE C

(Lactobacillus
rhamnosus)
PF03051
(Peptidase_C1_2)
5 ALA A 399
LEU A 368
ALA A 305
ILE A 306
LEU A 373
None
1.16A 3fl9F-4k7cA:
undetectable
3fl9F-4k7cA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk7 ESX-1 SECRETION
SYSTEM PROTEIN ECCB1


(Mycobacterium
tuberculosis)
PF05108
(T7SS_ESX1_EccB)
5 ALA A 296
LEU A 244
VAL A 289
ILE A 247
LEU A 282
None
1.21A 3fl9F-4kk7A:
undetectable
3fl9F-4kk7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A


(Homo sapiens)
PF10294
(Methyltransf_16)
5 ALA A  83
LEU A 141
VAL A  62
ALA A 172
ILE A 206
None
1.13A 3fl9F-4lecA:
undetectable
3fl9F-4lecA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nia COAT PROTEIN

(Tobacco
virtovirus 1)
no annotation 5 VAL A  55
ALA A  40
ILE A  41
LEU A  60
PHE A  43
None
A  d 167 ( 3.5A)
None
None
None
1.19A 3fl9F-4niaA:
undetectable
3fl9F-4niaA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE


(Mycobacterium
tuberculosis)
PF02558
(ApbA)
PF08546
(ApbA_C)
5 ALA A 162
LEU A 142
ALA A  96
ILE A  70
LEU A   7
None
1.04A 3fl9F-4ol9A:
undetectable
3fl9F-4ol9A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE


(Ruegeria
pomeroyi)
PF03480
(DctP)
5 MET A 102
ALA A 323
ILE A 120
LEU A 121
PHE A 105
None
1.15A 3fl9F-4pafA:
undetectable
3fl9F-4pafA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE SUBUNIT D


(Thermococcus
kodakarensis)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
5 ALA D  93
LEU D 123
ILE D  59
LEU D  63
PHE D 131
None
0.97A 3fl9F-4qiwD:
undetectable
3fl9F-4qiwD:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpn PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21B


(Homo sapiens)
PF10294
(Methyltransf_16)
5 ALA A  93
LEU A 148
VAL A  72
ALA A 179
ILE A 215
None
1.06A 3fl9F-4qpnA:
2.1
3fl9F-4qpnA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF00028
(Cadherin)
5 ALA A 294
LEU A 296
VAL A 374
LEU A 319
PHE A 329
None
1.20A 3fl9F-4ux8A:
undetectable
3fl9F-4ux8A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC


(Escherichia
coli)
PF02432
(Fimbrial_K88)
5 VAL A  54
ALA A 253
ILE A 277
LEU A  33
PHE A  36
None
1.16A 3fl9F-4wenA:
undetectable
3fl9F-4wenA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zij THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA


(Escherichia
coli)
PF01323
(DSBA)
5 ALA A 125
ALA A 105
ILE A 108
LEU A  92
PHE A 112
None
1.15A 3fl9F-4zijA:
undetectable
3fl9F-4zijA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA


(Mycolicibacterium
smegmatis)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 ALA A 271
LEU A 304
ALA A 281
ILE A 282
LEU A 338
None
1.17A 3fl9F-5ah4A:
undetectable
3fl9F-5ah4A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E


(Homo sapiens)
PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition)
5 ALA B 433
VAL B 449
ALA B 414
ILE B 459
LEU B 468
None
1.16A 3fl9F-5b4xB:
undetectable
3fl9F-5b4xB:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE


(Streptomyces
halstedii)
no annotation 5 ALA A 113
VAL A  85
ALA A 129
ILE A  78
PHE A 121
None
1.22A 3fl9F-5czcA:
undetectable
3fl9F-5czcA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli)
PF01212
(Beta_elim_lyase)
5 ALA A 208
ASN A 133
GLU A 242
ALA A 193
ILE A 195
None
1.10A 3fl9F-5d8gA:
undetectable
3fl9F-5d8gA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum)
PF13354
(Beta-lactamase2)
5 ALA A  79
VAL A 194
ALA A 127
ILE A 128
LEU A 212
None
0.78A 3fl9F-5e43A:
undetectable
3fl9F-5e43A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2


(Rattus
norvegicus)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 ALA A  74
VAL A 303
ALA A  29
ILE A  33
LEU A  40
None
1.20A 3fl9F-5kufA:
2.7
3fl9F-5kufA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mms CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
PF00291
(PALP)
5 ALA A 361
LEU A 101
VAL A 372
ILE A  95
LEU A 338
None
1.23A 3fl9F-5mmsA:
2.9
3fl9F-5mmsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002


(Bacteroides
thetaiotaomicron)
no annotation 5 ALA A 177
LEU A 251
VAL A 173
ALA A 193
ILE A 208
None
1.00A 3fl9F-5mqpA:
undetectable
3fl9F-5mqpA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 ALA B 421
ASN B 186
LEU B 189
LEU B 405
PHE B 399
None
1.12A 3fl9F-5n5nB:
undetectable
3fl9F-5n5nB:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE


(Pseudomonas
fluorescens)
PF01494
(FAD_binding_3)
5 ALA A 366
ASN A 325
ALA A  58
ILE A 106
LEU A 213
None
FAD  A 501 (-3.9A)
None
None
8R5  A 502 ( 4.6A)
1.05A 3fl9F-5nagA:
undetectable
3fl9F-5nagA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thz CURJ

(Moorea
producens)
no annotation 5 ALA B  69
LEU B  87
VAL B  75
ILE B  47
LEU B 142
None
1.17A 3fl9F-5thzB:
undetectable
3fl9F-5thzB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj5 ADRENODOXIN

(Encephalitozoon
cuniculi)
PF00111
(Fer2)
5 ALA A 111
LEU A  67
VAL A  39
LEU A  50
PHE A  22
None
1.07A 3fl9F-5uj5A:
undetectable
3fl9F-5uj5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3


(Pseudomonas
aeruginosa)
PF09615
(Cas_Csy3)
5 ALA C 234
LEU C 167
ALA C 174
ILE C 238
LEU C 103
None
1.14A 3fl9F-5uz9C:
undetectable
3fl9F-5uz9C:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqi IMPORTIN SUBUNIT
ALPHA


(Neurospora
crassa)
no annotation 5 LEU B 431
ALA B 498
ILE B 501
LEU B 450
PHE B 506
None
1.23A 3fl9F-5vqiB:
undetectable
3fl9F-5vqiB:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 ALA B 411
ASN B 184
LEU B 187
LEU B 395
PHE B 389
None
1.07A 3fl9F-5w3jB:
undetectable
3fl9F-5w3jB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa)
no annotation 5 LEU A 480
VAL A 531
ALA A 484
ILE A 550
LEU A 546
None
1.00A 3fl9F-5whsA:
undetectable
3fl9F-5whsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtn REPLICATION
INITIATION AND
MEMBRANE ATTACHMENT
PROTEIN


(Geobacillus
stearothermophilus)
no annotation 5 ALA A 232
LEU A 266
VAL A 225
LEU A 215
PHE A 211
None
1.17A 3fl9F-5wtnA:
undetectable
3fl9F-5wtnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE


(Staphylococcus
aureus)
no annotation 5 MET A 511
LEU A 177
ALA A 193
ILE A 506
LEU A 527
None
1.18A 3fl9F-5xexA:
undetectable
3fl9F-5xexA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2v RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR


(Synechocystis
sp. PCC 6803)
no annotation 5 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
None
1.09A 3fl9F-5y2vA:
undetectable
3fl9F-5y2vA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2w RUBISCO OPERON
TRANSCRIPTIONAL
REGULATOR


(Synechocystis
sp. PCC 6803)
no annotation 5 ALA A 204
VAL A 240
ILE A 184
LEU A 187
PHE A 209
None
1.14A 3fl9F-5y2wA:
undetectable
3fl9F-5y2wA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN


(Bifidobacterium
longum)
no annotation 5 ALA A 464
ASN A 504
VAL A 515
ALA A 505
ILE A 511
None
1.15A 3fl9F-5z9sA:
undetectable
3fl9F-5z9sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bii GLYOXYLATE REDUCTASE

(Pyrococcus
yayanosii)
no annotation 5 ASN A 282
VAL A 245
ALA A 261
ILE A 259
LEU A 227
None
1.21A 3fl9F-6biiA:
undetectable
3fl9F-6biiA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e4e -

(-)
no annotation 6 ALA A   7
LEU A  20
VAL A  31
ILE A  50
LEU A  54
PHE A  92
MMV  A 202 ( 3.5A)
MMV  A 202 (-4.3A)
MMV  A 202 (-4.9A)
MMV  A 202 ( 4.9A)
None
MMV  A 202 ( 3.5A)
0.63A 3fl9F-6e4eA:
25.1
3fl9F-6e4eA:
undetectable