SIMILAR PATTERNS OF AMINO ACIDS FOR 3FI0_P_TRPP1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C 100
VAL C  43
ILE C 104
GLN C  57
 None
 0.92A 3fi0P-1a5lC:
undetectable		 3fi0P-1a5lC:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		7 GLY A   7
GLN A   9
VAL A  40
HIS A  43
ASP A 132
ILE A 133
GLN A 147
 None
 0.49A 3fi0P-1d2rA:
40.1		 3fi0P-1d2rA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 GLY A 411
GLN A 406
VAL A 347
ILE A 417
 None
 0.91A 3fi0P-1ewkA:
undetectable		 3fi0P-1ewkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foh PHENOL HYDROXYLASE

(Cutaneotrichosporon
cutaneum) 		PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim) 		4 GLY A 118
GLN A  52
VAL A  48
ILE A 124
 None
FAD  A 801 ( 3.8A)
None
None
 0.93A 3fi0P-1fohA:
undetectable		 3fi0P-1fohA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.60A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.45A 3fi0P-1j1uA:
18.3		 3fi0P-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzg SUFE PROTEIN

(Escherichia
coli) 		PF02657
(SufE) 		4 GLN A  64
ASP A  96
ILE A  97
GLN A  61
 None
 0.86A 3fi0P-1mzgA:
undetectable		 3fi0P-1mzgA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLY A 171
ASP A 196
ILE A 194
GLN A 177
 None
 0.87A 3fi0P-1nowA:
undetectable		 3fi0P-1nowA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsv GALACTOSE MUTAROTASE

(Lactococcus
lactis) 		PF01263
(Aldose_epim) 		4 GLY A 177
HIS A 291
ILE A  45
GLN A  38
 None
 0.88A 3fi0P-1nsvA:
undetectable		 3fi0P-1nsvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLY A 250
GLN A 254
ASP A 223
ILE A 222
 None
ATP  A 726 ( 4.7A)
None
None
 0.89A 3fi0P-1qhgA:
undetectable		 3fi0P-1qhgA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxz CELLULASE B

(Cellvibrio
mixtus) 		PF03422
(CBM_6) 		4 GLY A  16
ASP A  35
ILE A  34
GLN A  18
 None
 0.90A 3fi0P-1uxzA:
undetectable		 3fi0P-1uxzA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zi0 DNA GYRASE SUBUNIT A

(Escherichia
coli) 		PF03989
(DNA_gyraseA_C) 		4 GLY A 785
VAL A 733
ILE A 774
GLN A 749
 None
 0.81A 3fi0P-1zi0A:
undetectable		 3fi0P-1zi0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		4 GLY A 189
VAL A 146
ASP A 240
ILE A 241
 NAP  A 800 (-4.7A)
None
None
None
 0.93A 3fi0P-2bd0A:
undetectable		 3fi0P-2bd0A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.53A 3fi0P-2cyaA:
20.4		 3fi0P-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.64A 3fi0P-2cyaA:
20.4		 3fi0P-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.81A 3fi0P-2cybA:
19.8		 3fi0P-2cybA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 GLY A  39
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 0.82A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		4 GLY A  39
HIS A  76
ASP A 175
ILE A 176
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
 0.90A 3fi0P-2cycA:
18.7		 3fi0P-2cycA:
25.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 GLY A   7
GLN A   9
VAL A  42
ASP A 136
ILE A 137
 None
 1.09A 3fi0P-2el7A:
31.9		 3fi0P-2el7A:
40.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 GLY A 101
GLN A 126
ILE A  80
GLN A 130
 None
 0.91A 3fi0P-2fk7A:
undetectable		 3fi0P-2fk7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		4 GLY A 129
ASP A 123
ILE A 145
GLN A 134
 None
 0.92A 3fi0P-2frxA:
undetectable		 3fi0P-2frxA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		5 GLY A   6
HIS A  43
ASP A 136
ILE A 137
GLN A 151
 TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-3.5A)
 0.54A 3fi0P-2g36A:
32.4		 3fi0P-2g36A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 4 GLY I 138
ASP I 163
ILE I 161
GLN I 144
 None
 0.93A 3fi0P-2gk1I:
undetectable		 3fi0P-2gk1I:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 4 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.74A 3fi0P-2gk1M:
undetectable		 3fi0P-2gk1M:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgl MESODERM DEVELOPMENT
CANDIDATE 2

(Mus musculus) 		PF10185
(Mesd) 		4 GLY A  84
ASP A  37
ILE A  38
GLN A  31
 None
 0.79A 3fi0P-2kglA:
undetectable		 3fi0P-2kglA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 GLN A 478
VAL A 825
ILE A 818
GLN A 471
 None
None
UNX  A  10 ( 4.8A)
None
 0.92A 3fi0P-2nztA:
undetectable		 3fi0P-2nztA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 GLY A 250
GLN A 254
ASP A 223
ILE A 222
 None
SO4  A 901 (-2.6A)
None
None
 0.87A 3fi0P-2pjrA:
2.0		 3fi0P-2pjrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		4 GLY A 345
HIS A 347
ASP A  56
GLN A  62
 None
ZN  A1476 ( 3.1A)
ZN  A1476 (-2.2A)
None
 0.93A 3fi0P-2x98A:
undetectable		 3fi0P-2x98A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLY A 413
HIS A 406
ASP A 477
ILE A 525
 None
 0.90A 3fi0P-2xn1A:
undetectable		 3fi0P-2xn1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 597
GLN A 601
ASP A 572
ILE A 571
GLN A 576
 None
ALF  A1855 (-3.0A)
MG  A1856 ( 4.0A)
None
None
 1.26A 3fi0P-2xzlA:
undetectable		 3fi0P-2xzlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1

(Homo sapiens) 		PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 GLY A 661
GLN A 665
ASP A 636
ILE A 635
GLN A 640
 None
ALF  A1005 (-3.0A)
MG  A1006 ( 4.0A)
None
None
 1.15A 3fi0P-2xzoA:
undetectable		 3fi0P-2xzoA:
19.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		6 GLY A   8
GLN A  10
HIS A  44
ASP A 140
ILE A 141
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.6A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
SO4  A1363 ( 3.2A)
 0.70A 3fi0P-2yy5A:
34.7		 3fi0P-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 329
VAL A  28
ILE A 332
GLN A 323
 None
 0.82A 3fi0P-3cq5A:
undetectable		 3fi0P-3cq5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 GLY A  85
VAL A  75
ILE A   3
GLN A  -1
 COA  A 300 (-3.6A)
COA  A 300 ( 4.3A)
EDO  A 301 (-4.7A)
None
 0.91A 3fi0P-3dddA:
undetectable		 3fi0P-3dddA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 GLY A  11
HIS A 316
ASP A  12
GLN A  18
 None
ZN  A 602 ( 3.2A)
ZN  A 602 (-2.2A)
None
 0.90A 3fi0P-3e2dA:
undetectable		 3fi0P-3e2dA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3er7 UNCHARACTERIZED
NTF2-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF12680
(SnoaL_2) 		4 GLY A 100
GLN A  98
ASP A 102
ILE A 103
 None
None
PEG  A 132 (-2.7A)
None
 0.87A 3fi0P-3er7A:
undetectable		 3fi0P-3er7A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy3 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		4 GLY A  77
GLN A  51
VAL A  73
ILE A 150
 None
 0.89A 3fi0P-3fy3A:
undetectable		 3fi0P-3fy3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 VAL A  85
HIS A  88
ASP A 238
ILE A 237
 None
 0.81A 3fi0P-3g4fA:
undetectable		 3fi0P-3g4fA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 GLY B 966
GLN B 964
VAL B1088
ILE A 359
 None
 0.92A 3fi0P-3h0gB:
undetectable		 3fi0P-3h0gB:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.66A 3fi0P-3iayA:
undetectable		 3fi0P-3iayA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLY A 398
GLN A 393
VAL A 334
ILE A 404
 None
 0.82A 3fi0P-3lmkA:
undetectable		 3fi0P-3lmkA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		5 GLY A   6
HIS A  42
ASP A 131
ILE A 132
GLN A 146
 None
 0.60A 3fi0P-3m5wA:
32.2		 3fi0P-3m5wA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9x D-XYLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		4 GLY A 259
VAL A   3
ILE A 254
GLN A 262
 None
 0.85A 3fi0P-3m9xA:
undetectable		 3fi0P-3m9xA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		7 GLY A  21
GLN A  23
VAL A  54
HIS A  57
ASP A 147
ILE A 148
GLN A 162
 GOL  A1001 (-3.6A)
None
GOL  A1001 (-4.6A)
GOL  A1001 ( 4.7A)
GOL  A1001 (-3.9A)
None
None
 0.27A 3fi0P-3n9iA:
37.2		 3fi0P-3n9iA:
54.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nb6 PENICILLIN-BINDING
PROTEIN 1A

(Aquifex
aeolicus) 		PF00912
(Transgly) 		4 GLY A 115
ASP A  94
ILE A  93
GLN A 121
 None
 0.92A 3fi0P-3nb6A:
undetectable		 3fi0P-3nb6A:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		7 GLY A   8
GLN A  10
VAL A  41
HIS A  44
ASP A 133
ILE A 134
GLN A 148
 None
 0.64A 3fi0P-3prhA:
38.9		 3fi0P-3prhA:
69.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sut BETA-HEXOSAMINIDASE

(Paenibacillus
sp. TS12) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 123
ASP A 155
ILE A 153
GLN A 129
 None
 0.81A 3fi0P-3sutA:
undetectable		 3fi0P-3sutA:
18.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		5 GLY A   9
GLN A  11
VAL A  42
ASP A 135
ILE A 136
 TRP  A 401 (-3.8A)
TRP  A 401 (-3.2A)
TRP  A 401 (-4.7A)
TRP  A 401 (-4.0A)
None
 0.70A 3fi0P-3sz3A:
37.2		 3fi0P-3sz3A:
52.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 GLY A 248
VAL A 218
ILE A 568
GLN A 253
 None
 0.93A 3fi0P-3u1kA:
undetectable		 3fi0P-3u1kA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 GLY A 117
VAL A  63
ILE A 111
GLN A 164
 None
 0.82A 3fi0P-3v8bA:
undetectable		 3fi0P-3v8bA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 GLY A 430
ASP A 293
ILE A 292
GLN A 437
 None
 0.78A 3fi0P-3v98A:
undetectable		 3fi0P-3v98A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLY A 178
ASP A 205
ILE A 203
GLN A 184
 None
 0.91A 3fi0P-3vtrA:
undetectable		 3fi0P-3vtrA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbh ALKALINE PHOSPHATASE

(Halomonas sp.
#593) 		PF00245
(Alk_phosphatase) 		4 GLY A  11
HIS A 312
ASP A  12
GLN A  18
 None
ZN  A 505 (-3.1A)
ZN  A 505 ( 2.1A)
None
 0.90A 3fi0P-3wbhA:
undetectable		 3fi0P-3wbhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 GLY A 276
ASP A 300
ILE A 299
GLN A 270
 None
 0.70A 3fi0P-3wcyA:
undetectable		 3fi0P-3wcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 GLY A 482
HIS A  88
ASP A 138
ILE A 136
 None
 0.90A 3fi0P-3wevA:
undetectable		 3fi0P-3wevA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlc ER-DERIVED VESICLES
PROTEIN ERV41

(Saccharomyces
cerevisiae) 		PF07970
(COPIIcoated_ERV)
PF13850
(ERGIC_N) 		4 GLY A 166
GLN A  99
ASP A  70
ILE A  71
 None
 0.93A 3fi0P-3zlcA:
undetectable		 3fi0P-3zlcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 GLN A 322
VAL A 324
HIS A 226
ASP A 337
ILE A 266
 None
 1.33A 3fi0P-4ay1A:
undetectable		 3fi0P-4ay1A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csu GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		4 GLY 9 163
VAL 9 211
ASP 9 213
ILE 9 214
 None
 0.85A 3fi0P-4csu9:
undetectable		 3fi0P-4csu9:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		4 GLY A   9
VAL A  18
ILE A  32
GLN A  36
 None
 0.91A 3fi0P-4e4yA:
undetectable		 3fi0P-4e4yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo9 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 GLN A 140
VAL A  29
ASP A  23
ILE A 144
 None
 0.87A 3fi0P-4mo9A:
undetectable		 3fi0P-4mo9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 GLY A 194
VAL A 131
ILE A 212
GLN A 339
 None
 0.87A 3fi0P-4nq3A:
undetectable		 3fi0P-4nq3A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		4 GLY A 143
VAL A 216
ASP A 214
ILE A 211
 None
 0.73A 3fi0P-4ns4A:
undetectable		 3fi0P-4ns4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		5 GLY A  83
VAL A  85
HIS A 171
ASP A 169
GLN A 289
 None
None
ZN  A 401 (-3.1A)
None
None
 1.45A 3fi0P-4okoA:
undetectable		 3fi0P-4okoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oko RAPID ENCYSTMENT
PHENOTYPE PROTEIN 34
KDA

(Francisella
tularensis) 		PF00246
(Peptidase_M14) 		5 GLY A  83
VAL A  85
HIS A 171
ASP A 169
ILE A 168
 None
None
ZN  A 401 (-3.1A)
None
None
 1.34A 3fi0P-4okoA:
undetectable		 3fi0P-4okoA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0d TRYPSIN-RESISTANT
SURFACE T6 PROTEIN

(Streptococcus
pyogenes) 		PF16569
(GramPos_pilinBB) 		4 GLY A 371
VAL A 383
ASP A 381
ILE A 380
 None
 0.92A 3fi0P-4p0dA:
undetectable		 3fi0P-4p0dA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		4 GLY A 739
GLN A 741
VAL A 820
ILE A 585
 None
 0.88A 3fi0P-4ppmA:
undetectable		 3fi0P-4ppmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		4 GLY A  96
HIS A  81
ILE A 191
GLN A  94
 None
 0.91A 3fi0P-4pxdA:
undetectable		 3fi0P-4pxdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		4 GLY A 252
HIS A 226
ASP A 148
ILE A 149
 None
ZN  A 403 ( 3.2A)
ZN  A 403 ( 2.6A)
None
 0.94A 3fi0P-4rgqA:
undetectable		 3fi0P-4rgqA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1
LINKER L2

(Glossoscolex
paulistus;
Glossoscolex
paulistus) 		PF16915
(Eryth_link_C)
PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		4 GLY M 218
GLN M 207
VAL M 216
GLN N  81
 None
 0.89A 3fi0P-4u8uM:
undetectable		 3fi0P-4u8uM:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xct MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 GLY A 195
HIS A 118
ASP A 165
ILE A 166
 GOL  A 313 (-3.6A)
GOL  A 313 ( 3.9A)
None
None
 0.86A 3fi0P-4xctA:
undetectable		 3fi0P-4xctA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 GLY A 908
GLN A 842
VAL A 912
ILE A 977
 None
 0.90A 3fi0P-4xqkA:
undetectable		 3fi0P-4xqkA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2m PUTATIVE
METAL-BINDING
TRANSPORT PROTEIN

(Salmonella
enterica) 		PF00403
(HMA) 		4 GLY A  58
ASP A   7
ILE A   5
GLN A  55
 None
 0.89A 3fi0P-4y2mA:
undetectable		 3fi0P-4y2mA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywh ABC TRANSPORTER
SOLUTE BINDING
PROTEIN

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 GLY A  29
VAL A  82
ILE A  87
GLN A  61
 None
 0.88A 3fi0P-4ywhA:
undetectable		 3fi0P-4ywhA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 GLY A 260
GLN A 262
ILE A 505
GLN A 547
 None
 0.89A 3fi0P-5aeeA:
undetectable		 3fi0P-5aeeA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5an9 60S RIBOSOMAL
PROTEIN L3
60S RIBOSOMAL
PROTEIN L23
60S RIBOSOMAL
PROTEIN L24

(Dictyostelium
discoideum;
Dictyostelium
discoideum;
Dictyostelium
discoideum) 		PF00297
(Ribosomal_L3)
PF00238
(Ribosomal_L14)
PF01246
(Ribosomal_L24e) 		4 GLY E  90
VAL A  73
HIS A  55
ILE G  13
 None
None
A  N3385 ( 3.0A)
None
 0.91A 3fi0P-5an9E:
undetectable		 3fi0P-5an9E:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 GLN A 686
VAL A 706
ASP A 728
ILE A 729
 None
 0.92A 3fi0P-5aorA:
undetectable		 3fi0P-5aorA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza C
virus) 		PF00603
(Flu_PA) 		4 GLY A  66
HIS A  41
ASP A  93
ILE A  94
 None
 0.93A 3fi0P-5d9aA:
undetectable		 3fi0P-5d9aA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		7 GLY A  40
GLN A  42
VAL A  74
HIS A  77
ASP A 167
ILE A 168
GLN A 182
 5BX  A 401 (-3.9A)
5BX  A 401 ( 3.4A)
5BX  A 401 ( 4.9A)
5BX  A 401 (-3.5A)
5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
5BX  A 401 ( 3.0A)
 0.65A 3fi0P-5ekdA:
35.4		 3fi0P-5ekdA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhh ATP-DEPENDENT DNA
HELICASE PIF1

(Homo sapiens) 		PF02689
(Herpes_Helicase)
PF05970
(PIF1) 		4 GLY A 342
GLN A 346
ASP A 306
ILE A 305
 ALF  A 702 ( 4.7A)
ALF  A 702 (-2.2A)
ALF  A 702 ( 4.0A)
None
 0.73A 3fi0P-5fhhA:
undetectable		 3fi0P-5fhhA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ho1 MAGNETOSOME PROTEIN
MAMB

(Magnetospira
sp. QH-2) 		PF16916
(ZT_dimer) 		4 GLY A 237
HIS A 245
ASP A 247
ILE A 248
 None
ZN  A 301 (-3.4A)
ZN  A 301 (-2.1A)
None
 0.84A 3fi0P-5ho1A:
undetectable		 3fi0P-5ho1A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i33 ADENYLOSUCCINATE
SYNTHETASE

(Cryptococcus
neoformans) 		PF00709
(Adenylsucc_synt) 		4 GLY A 142
VAL A 116
HIS A  85
ILE A 122
 None
 0.92A 3fi0P-5i33A:
undetectable		 3fi0P-5i33A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 GLY A 367
GLN A 363
VAL A 357
ILE A 545
 None
 0.82A 3fi0P-5jxfA:
undetectable		 3fi0P-5jxfA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		4 GLY B 270
VAL B 297
ILE B 290
GLN B 259
 None
 0.85A 3fi0P-5k1cB:
undetectable		 3fi0P-5k1cB:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 GLY A 352
HIS A 308
ASP A1177
ILE A1178
 None
 0.82A 3fi0P-5k94A:
undetectable		 3fi0P-5k94A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3q EUKARYOTIC
TRANSLATION
INITIATION FACTOR 6

(Chaetomium
thermophilum) 		PF01912
(eIF-6) 		4 GLY A 159
VAL A 221
ILE A 193
GLN A 170
 None
 0.84A 3fi0P-5m3qA:
undetectable		 3fi0P-5m3qA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m85 SENSORY TRANSDUCTION
HISTIDINE KINASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A 583
VAL A 546
ILE A 444
GLN A 581
 None
 0.80A 3fi0P-5m85A:
undetectable		 3fi0P-5m85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLY A 189
VAL A 442
ILE A 161
GLN A 226
 None
 0.91A 3fi0P-5macA:
undetectable		 3fi0P-5macA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 GLY C 432
GLN C 404
ASP C 399
ILE C 428
 None
 0.91A 3fi0P-5o4gC:
undetectable		 3fi0P-5o4gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sz8 HEMOLYSIN

(Proteus
mirabilis) 		PF05860
(Haemagg_act) 		4 GLY A  77
GLN A  51
VAL A  73
ILE A 150
 None
 0.88A 3fi0P-5sz8A:
undetectable		 3fi0P-5sz8A:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		4 GLY A   9
HIS A  47
ASP A 145
ILE A 146
 None
 0.27A 3fi0P-5tevA:
32.1		 3fi0P-5tevA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th6 MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9

(Homo sapiens) 		PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 GLY A 195
HIS A 118
ASP A 165
ILE A 166
 None
 0.89A 3fi0P-5th6A:
undetectable		 3fi0P-5th6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thh TYROSINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		4 GLY A  41
HIS A  77
ASP A 173
GLN A 188
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.4A)
TYR  A 401 (-3.0A)
 0.83A 3fi0P-5thhA:
16.9		 3fi0P-5thhA:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		7 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
TRP  A 402 (-3.1A)
 0.31A 3fi0P-5v0iA:
38.6		 3fi0P-5v0iA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7q CONSENSUS ELONGATION
FACTOR

(synthetic
construct) 		no annotation 4 GLY A 101
GLN A  98
VAL A 128
ILE A 103
 None
 0.85A 3fi0P-5w7qA:
undetectable		 3fi0P-5w7qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmi VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF04212
(MIT) 		4 GLY A 333
VAL A 417
ASP A 338
ILE A 339
 None
 0.92A 3fi0P-5xmiA:
undetectable		 3fi0P-5xmiA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y29 INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 4 GLY A1857
VAL A1816
HIS A1815
ASP A1938
 None
 0.91A 3fi0P-5y29A:
undetectable		 3fi0P-5y29A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avo PROTEASOME SUBUNIT
BETA TYPE-10

(Homo sapiens) 		no annotation 4 GLY B 102
GLN B 109
VAL B  76
ILE B  99
 None
 0.93A 3fi0P-6avoB:
undetectable		 3fi0P-6avoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 7 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
TRP  A 501 (-3.3A)
 0.76A 3fi0P-6dfuA:
38.6		 3fi0P-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fju -

(-) 		no annotation 4 VAL A 114
HIS A  85
ASP A  96
ILE A  97
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-2.5A)
None
 0.94A 3fi0P-6fjuA:
undetectable		 3fi0P-6fjuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fno -

(-) 		no annotation 4 VAL A 114
HIS A  85
ASP A  96
ILE A  97
 None
ZN  A 201 (-3.2A)
ZN  A 201 (-2.1A)
None
 0.85A 3fi0P-6fnoA:
undetectable		 3fi0P-6fnoA:
undetectable