SIMILAR PATTERNS OF AMINO ACIDS FOR 3FI0_I_TRPI1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A 179
ILE A 137
VAL A 154
VAL A 165
 None
 0.72A 3fi0I-1a3xA:
undetectable		 3fi0I-1a3xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap2 MONOCLONAL ANTIBODY
C219

(Mus musculus) 		PF07686
(V-set) 		4 GLY A  16
ILE A  81
VAL A  19
VAL A  13
 None
 0.75A 3fi0I-1ap2A:
undetectable		 3fi0I-1ap2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 GLY A 229
ILE A  11
VAL A 270
GLN A  17
 None
 0.81A 3fi0I-1c3lA:
undetectable		 3fi0I-1c3lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4x PROTEIN
(2-HYDROXY-6-OXO-6-P
HENYLHEXA-2,4-DIENOA
TE HYDROLASE)

(Rhodococcus
jostii) 		PF12697
(Abhydrolase_6) 		5 GLY A  69
HIS A  35
VAL A 189
VAL A 195
GLN A 199
 None
 1.38A 3fi0I-1c4xA:
undetectable		 3fi0I-1c4xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 GLY A  55
ILE A  42
VAL A  31
VAL A  27
 None
 0.80A 3fi0I-1c9wA:
undetectable		 3fi0I-1c9wA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 5 GLY P   8
ASP P  84
ILE P  83
VAL P  16
VAL P  12
 NAP  P 340 (-3.2A)
None
None
None
NAP  P 340 (-3.9A)
 1.36A 3fi0I-1cf2P:
undetectable		 3fi0I-1cf2P:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		8 GLY A   7
VAL A  40
HIS A  43
ASP A 132
ILE A 133
VAL A 141
VAL A 143
GLN A 147
 None
 0.47A 3fi0I-1d2rA:
41.4		 3fi0I-1d2rA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		5 GLY A  27
VAL A  32
ILE A 390
VAL A  52
VAL A  56
 None
 1.44A 3fi0I-1d9zA:
undetectable		 3fi0I-1d9zA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 699
VAL A 663
ILE A 713
VAL A 689
VAL A 761
 None
 1.24A 3fi0I-1dmsA:
undetectable		 3fi0I-1dmsA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLY A 699
VAL A 663
ILE A 713
VAL A 689
VAL A 761
 None
 1.24A 3fi0I-1eu1A:
undetectable		 3fi0I-1eu1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 ASP A  37
ILE A 321
VAL A 282
VAL A 269
 None
 0.76A 3fi0I-1gzgA:
undetectable		 3fi0I-1gzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1c HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 GLY A 137
ILE A 163
VAL A 142
VAL A 100
 None
 0.71A 3fi0I-1h1cA:
undetectable		 3fi0I-1h1cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2h HYPOTHETICAL PROTEIN
TM1643

(Thermotoga
maritima) 		PF01958
(DUF108)
PF03447
(NAD_binding_3) 		4 GLY A 174
ILE A 169
VAL A 126
VAL A 123
 None
 0.74A 3fi0I-1h2hA:
undetectable		 3fi0I-1h2hA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 VAL A 372
HIS A 347
ILE A 343
VAL A 415
VAL A 412
 None
 1.27A 3fi0I-1i7oA:
undetectable		 3fi0I-1i7oA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 GLY A  34
HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.87A 3fi0I-1j1uA:
18.8		 3fi0I-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 GLY A 388
ILE A 364
VAL A 367
VAL A 375
 None
 0.71A 3fi0I-1k32A:
undetectable		 3fi0I-1k32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko6 NUCLEAR PORE COMPLEX
PROTEIN NUP98

(Homo sapiens) 		PF04096
(Nucleoporin2) 		4 VAL A 764
ILE A 750
VAL A 775
VAL A 784
 None
 0.81A 3fi0I-1ko6A:
undetectable		 3fi0I-1ko6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE

(Methanothermobacter
marburgensis) 		PF02240
(MCR_gamma) 		4 GLY C 202
ILE C  31
VAL C 199
GLN C 175
 None
 0.76A 3fi0I-1mroC:
undetectable		 3fi0I-1mroC:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 GLY A   9
ASP A 110
ILE A 111
VAL A  13
 None
 0.80A 3fi0I-1o60A:
undetectable		 3fi0I-1o60A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odg DNA MISMATCH
ENDONUCLEASE

(Escherichia
coli) 		PF03852
(Vsr) 		5 GLY A  48
HIS A  64
ASP A  97
ILE A 101
VAL A  60
 None
 1.36A 3fi0I-1odgA:
undetectable		 3fi0I-1odgA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A1042
ILE A1056
VAL A1048
GLN A 501
 None
 0.77A 3fi0I-1ofeA:
undetectable		 3fi0I-1ofeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pf5 HYPOTHETICAL PROTEIN
YJGH

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 ASP A  73
ILE A  74
VAL A 124
VAL A  33
 HG  A 132 (-3.4A)
None
None
None
 0.74A 3fi0I-1pf5A:
undetectable		 3fi0I-1pf5A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		4 GLY A 133
VAL A 129
ILE A  93
VAL A 147
 None
 0.76A 3fi0I-1przA:
undetectable		 3fi0I-1przA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  35
ILE A  36
VAL A 146
VAL A  93
 None
 0.78A 3fi0I-1q1nA:
undetectable		 3fi0I-1q1nA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5m PROSTAGLANDIN-E2
9-REDUCTASE

(Oryctolagus
cuniculus) 		PF00248
(Aldo_ket_red) 		5 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NDP  A1003 (-3.7A)
 1.12A 3fi0I-1q5mA:
undetectable		 3fi0I-1q5mA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY B 320
ILE B 369
VAL B 323
VAL B 294
 None
 0.81A 3fi0I-1tqyB:
undetectable		 3fi0I-1tqyB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz0 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF03992
(ABM) 		4 VAL A  13
HIS A  90
VAL A  56
VAL A  42
 None
 0.74A 3fi0I-1tz0A:
undetectable		 3fi0I-1tz0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1

(Homo sapiens) 		PF07679
(I-set) 		4 GLY A  34
ASP A  36
VAL A  31
VAL A 110
 None
 0.80A 3fi0I-1u2hA:
undetectable		 3fi0I-1u2hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uep MEMBRANE ASSOCIATED
GUANYLATE KINASE
INVERTED-2 (MAGI-2)

(Homo sapiens) 		PF00595
(PDZ) 		4 GLY A  29
ILE A  26
VAL A  75
VAL A  67
 None
 0.69A 3fi0I-1uepA:
undetectable		 3fi0I-1uepA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umi F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF04300
(FBA) 		5 VAL A 288
HIS A 272
ASP A 209
ILE A 254
VAL A 243
 None
 1.14A 3fi0I-1umiA:
undetectable		 3fi0I-1umiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 GLY A 158
ILE A 202
VAL A 173
VAL A 222
 None
 0.81A 3fi0I-1vi1A:
2.2		 3fi0I-1vi1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		5 GLY A 142
HIS A 169
ILE A 144
VAL A  58
VAL A  90
 None
 1.26A 3fi0I-1vp8A:
undetectable		 3fi0I-1vp8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp8 HYPOTHETICAL PROTEIN
AF0103

(Archaeoglobus
fulgidus) 		PF02887
(PK_C) 		5 GLY A 142
HIS A 169
ILE A 144
VAL A  90
GLN A  92
 None
 1.12A 3fi0I-1vp8A:
undetectable		 3fi0I-1vp8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		4 GLY A 251
ILE A 261
VAL A 210
GLN A 200
 None
 0.74A 3fi0I-1wp5A:
undetectable		 3fi0I-1wp5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		5 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.01A 3fi0I-1xfgA:
undetectable		 3fi0I-1xfgA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 263
ILE A 164
VAL A 170
VAL A 172
 None
 0.80A 3fi0I-1y9aA:
undetectable		 3fi0I-1y9aA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		4 GLY A  19
VAL A   6
VAL A  27
GLN A  25
 None
 0.75A 3fi0I-1zovA:
undetectable		 3fi0I-1zovA:
21.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 GLY A  28
ASP A 157
ILE A 158
VAL A 166
GLN A 172
 None
 0.97A 3fi0I-2a4mA:
32.7		 3fi0I-2a4mA:
31.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 GLY A 118
ASP A 178
ILE A 179
VAL A 109
 None
 0.71A 3fi0I-2a9vA:
undetectable		 3fi0I-2a9vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap2 SINGLE CHAIN FV

(Mus musculus) 		PF07686
(V-set) 		4 GLY A  16
ILE A  81
VAL A  19
VAL A  13
 None
 0.80A 3fi0I-2ap2A:
undetectable		 3fi0I-2ap2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2arf WILSON DISEASE
ATPASE

(Homo sapiens) 		PF00702
(Hydrolase) 		4 ASP A1185
ILE A1184
VAL A1056
VAL A1059
 None
 0.81A 3fi0I-2arfA:
undetectable		 3fi0I-2arfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.79A 3fi0I-2az3A:
undetectable		 3fi0I-2az3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.44A 3fi0I-2cyaA:
6.1		 3fi0I-2cyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.59A 3fi0I-2cyaA:
6.1		 3fi0I-2cyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.78A 3fi0I-2cybA:
20.2		 3fi0I-2cybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyc TYROSYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00579
(tRNA-synt_1b) 		5 GLY A  39
HIS A  76
ASP A 175
ILE A 176
GLN A 190
 TYR  A 701 (-3.4A)
TYR  A 701 (-3.7A)
TYR  A 701 (-3.4A)
None
TYR  A 701 (-3.3A)
 1.02A 3fi0I-2cycA:
18.9		 3fi0I-2cycA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e32 F-BOX ONLY PROTEIN 2

(Mus musculus) 		PF00646
(F-box)
PF04300
(FBA) 		5 VAL A 288
HIS A 272
ASP A 209
ILE A 254
VAL A 243
 None
 1.17A 3fi0I-2e32A:
undetectable		 3fi0I-2e32A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		6 GLY A   7
VAL A  42
ASP A 136
ILE A 137
VAL A 145
VAL A 147
 None
 0.86A 3fi0I-2el7A:
32.9		 3fi0I-2el7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 GLY A   7
VAL A  42
VAL A 145
VAL A 147
GLN A 151
 None
 0.89A 3fi0I-2el7A:
32.9		 3fi0I-2el7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLY A 250
VAL A 204
VAL A  97
VAL A 129
 None
 0.80A 3fi0I-2f43A:
undetectable		 3fi0I-2f43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkj OUTER SURFACE
PROTEIN A

(Borreliella
burgdorferi) 		PF00820
(Lipoprotein_1) 		4 GLY A  65
ILE A  90
VAL A  40
VAL A  42
 None
 0.80A 3fi0I-2fkjA:
undetectable		 3fi0I-2fkjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fyw CONSERVED
HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF01784
(NIF3) 		4 GLY A 135
ASP A 103
ILE A 104
GLN A 126
 None
 0.80A 3fi0I-2fywA:
undetectable		 3fi0I-2fywA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		7 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
VAL A 147
GLN A 151
 TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
 0.63A 3fi0I-2g36A:
33.2		 3fi0I-2g36A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 4 GLY M 171
ASP M 196
ILE M 194
GLN M 177
 None
 0.76A 3fi0I-2gk1M:
undetectable		 3fi0I-2gk1M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 GLY A  20
ILE A  16
VAL A 266
VAL A 214
GLN A 190
 None
None
None
None
NAP  A   1 (-3.8A)
 1.13A 3fi0I-2ipfA:
undetectable		 3fi0I-2ipfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 GLY A  55
ILE A  42
VAL A  31
VAL A  27
 None
 0.74A 3fi0I-2is7A:
undetectable		 3fi0I-2is7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ist RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2)
PF01479
(S4) 		4 GLY A 133
VAL A 129
ILE A  93
VAL A 147
 None
 0.81A 3fi0I-2istA:
undetectable		 3fi0I-2istA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j23 THIOREDOXIN

(Malassezia
sympodialis) 		PF00085
(Thioredoxin) 		5 VAL A  89
ASP A  87
ILE A  86
VAL A  20
VAL A  52
 None
 1.22A 3fi0I-2j23A:
undetectable		 3fi0I-2j23A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 GLY A  68
VAL A  12
ILE A 189
VAL A 159
VAL A  96
 None
 1.06A 3fi0I-2j6hA:
undetectable		 3fi0I-2j6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kpw LAMIN-B1

(Homo sapiens) 		PF00932
(LTD) 		4 GLY A  95
ASP A  21
ILE A  20
VAL A 100
 None
 0.80A 3fi0I-2kpwA:
undetectable		 3fi0I-2kpwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n59 PUTATIVE
UNCHARACTERIZED
PROTEIN CSGH

(Rhodopseudomonas
palustris) 		no annotation 4 GLY A  29
ILE A  21
VAL A  81
VAL A  86
 None
 0.76A 3fi0I-2n59A:
undetectable		 3fi0I-2n59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 GLY C 116
HIS C 241
ILE C 123
VAL C 189
 None
MN  C 501 (-3.1A)
None
None
 0.76A 3fi0I-2nymC:
undetectable		 3fi0I-2nymC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnm PROTEASE VP4

(Infectious
pancreatic
necrosis virus) 		PF01768
(Birna_VP4) 		4 GLY A 637
VAL A 543
ILE A 596
VAL A 642
 None
 0.81A 3fi0I-2pnmA:
undetectable		 3fi0I-2pnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsi PUTATIVE HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HUPG

(Rhodopseudomonas
palustris) 		PF07449
(HyaE) 		4 GLY A  31
ILE A  27
VAL A  34
VAL A  67
 None
 0.71A 3fi0I-2qsiA:
undetectable		 3fi0I-2qsiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhe BENCE-JONES PROTEIN
RHE (LIGHT CHAIN)

(Homo sapiens) 		PF07686
(V-set) 		5 GLY A 100
ASP A  28
ILE A  29
VAL A  34
GLN A   6
 None
 1.48A 3fi0I-2rheA:
undetectable		 3fi0I-2rheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A  74
VAL A  76
ILE A 151
VAL A 133
 None
 0.79A 3fi0I-2vdcA:
undetectable		 3fi0I-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A1007
ILE A1021
VAL A1013
GLN A 505
 None
 0.81A 3fi0I-2vdcA:
undetectable		 3fi0I-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 VAL A  74
ASP A  79
ILE A  80
VAL A  18
VAL A  93
 FK5  A 501 (-3.5A)
None
None
None
None
 1.07A 3fi0I-2vn1A:
undetectable		 3fi0I-2vn1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvq RIBOSE-5-PHOSPHATE
ISOMERASE B

(Mycobacterium
tuberculosis) 		PF02502
(LacAB_rpiB) 		4 GLY A  65
ILE A  21
VAL A 124
VAL A 128
 None
 0.77A 3fi0I-2vvqA:
undetectable		 3fi0I-2vvqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 GLY A 274
VAL A 163
ILE A 186
VAL A 237
VAL A 279
 None
 1.25A 3fi0I-2xqyA:
undetectable		 3fi0I-2xqyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		4 GLY F 488
ILE F 555
VAL F 514
VAL F 516
 None
 0.78A 3fi0I-2xwbF:
undetectable		 3fi0I-2xwbF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y89 PHOSPHORIBOSYL
ISOMERASE A

(Mycobacterium
tuberculosis) 		PF00977
(His_biosynth) 		4 GLY A  32
ASP A  36
VAL A  10
VAL A  12
 None
 0.64A 3fi0I-2y89A:
undetectable		 3fi0I-2y89A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		7 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.46A 3fi0I-2yy5A:
35.3		 3fi0I-2yy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A  67
ILE A  70
VAL A  64
VAL A 144
 None
 0.69A 3fi0I-2zooA:
undetectable		 3fi0I-2zooA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLY A 206
ASP A 183
ILE A 184
VAL A 210
 None
None
None
A5A  A 801 (-4.8A)
 0.74A 3fi0I-2ztgA:
undetectable		 3fi0I-2ztgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		4 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.77A 3fi0I-2zuaA:
undetectable		 3fi0I-2zuaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyg 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Klebsiella
pneumoniae) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 GLY A  26
ILE A  22
VAL A  29
GLN A   5
 None
 0.81A 3fi0I-2zygA:
undetectable		 3fi0I-2zygA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		6 GLY A  76
ASP A 195
ILE A 196
VAL A 212
VAL A 214
GLN A 218
 TRP  A 377 (-3.6A)
TRP  A 377 (-3.6A)
None
None
None
None
 1.17A 3fi0I-3a05A:
22.6		 3fi0I-3a05A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ASP A 337
ILE A 338
VAL A 235
GLN A 233
 None
 0.81A 3fi0I-3bfjA:
undetectable		 3fi0I-3bfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cav 3-OXO-5-BETA-STEROID
4-DEHYDROGENASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 GLY A  22
ILE A  18
VAL A 269
GLN A 193
 None
None
None
NAP  A 327 (-3.8A)
 0.79A 3fi0I-3cavA:
undetectable		 3fi0I-3cavA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 VAL A  17
ILE A  21
VAL A 101
VAL A  91
 None
 0.71A 3fi0I-3ce1A:
undetectable		 3fi0I-3ce1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		4 GLY A 329
VAL A  28
ILE A 332
GLN A 323
 None
 0.81A 3fi0I-3cq5A:
undetectable		 3fi0I-3cq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlo UNIVERSAL STRESS
PROTEIN

(Archaeoglobus
fulgidus) 		PF00582
(Usp) 		4 GLY A 103
VAL A  20
ILE A 100
VAL A 122
 UNL  A 202 ( 4.8A)
None
None
None
 0.78A 3fi0I-3dloA:
5.3		 3fi0I-3dloA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmy PROTEIN FDRA

(Escherichia
coli) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 GLY A 405
ASP A 403
VAL A 410
GLN A 409
 None
 0.78A 3fi0I-3dmyA:
undetectable		 3fi0I-3dmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebl GIBBERELLIN RECEPTOR
GID1

(Oryza sativa) 		PF07859
(Abhydrolase_3) 		4 ASP A  71
ILE A  70
VAL A  78
VAL A 152
 None
 0.80A 3fi0I-3eblA:
undetectable		 3fi0I-3eblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edm SHORT CHAIN
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF13561
(adh_short_C2) 		5 GLY A  15
ASP A  17
ILE A  18
VAL A  91
VAL A  11
 None
 1.13A 3fi0I-3edmA:
undetectable		 3fi0I-3edmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 VAL A  85
HIS A  88
ASP A 238
ILE A 237
 None
 0.78A 3fi0I-3g4fA:
undetectable		 3fi0I-3g4fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLY A1068
HIS A1373
VAL A 856
VAL A 862
GLN A 871
 None
 0.95A 3fi0I-3h0gA:
undetectable		 3fi0I-3h0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h95 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		PF00293
(NUDIX) 		4 ASP A 183
ILE A 184
VAL A 146
GLN A 143
 None
 0.79A 3fi0I-3h95A:
undetectable		 3fi0I-3h95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm7 ALLANTOINASE

(Bacillus
halodurans) 		PF01979
(Amidohydro_1) 		5 GLY A 257
ILE A 252
VAL A 262
VAL A 260
GLN A 232
 None
 1.05A 3fi0I-3hm7A:
undetectable		 3fi0I-3hm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 GLY D  56
ILE D  74
VAL D  52
VAL D  59
 None
 0.78A 3fi0I-3hrdD:
undetectable		 3fi0I-3hrdD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hug RNA POLYMERASE SIGMA
FACTOR

(Mycobacterium
tuberculosis) 		PF04545
(Sigma70_r4) 		4 GLY A 149
ASP A 147
ILE A 144
VAL A 155
 None
 0.76A 3fi0I-3hugA:
undetectable		 3fi0I-3hugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		4 GLY A 192
VAL A 206
ILE A 199
VAL A 196
 None
 0.71A 3fi0I-3hyvA:
undetectable		 3fi0I-3hyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.73A 3fi0I-3iayA:
undetectable		 3fi0I-3iayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idu UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF07705
(CARDB) 		4 GLY A 446
ILE A 513
VAL A 537
VAL A 450
 None
 0.77A 3fi0I-3iduA:
undetectable		 3fi0I-3iduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 336
VAL C 281
VAL C  94
VAL C 217
 None
 0.76A 3fi0I-3j9uC:
undetectable		 3fi0I-3j9uC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 GLY A 119
ILE A 122
VAL A 116
VAL A 177
 None
 0.58A 3fi0I-3jrrA:
undetectable		 3fi0I-3jrrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		4 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.81A 3fi0I-3k53A:
undetectable		 3fi0I-3k53A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.79A 3fi0I-3krbA:
undetectable		 3fi0I-3krbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		4 GLY A   9
ILE A  14
VAL A 135
VAL A  83
 GOL  A 255 (-3.3A)
None
None
None
 0.73A 3fi0I-3kzvA:
undetectable		 3fi0I-3kzvA:
undetectable