SIMILAR PATTERNS OF AMINO ACIDS FOR 3FI0_G_TRPG1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		4 VAL A 179
ILE A 137
VAL A 154
VAL A 165
 None
 0.72A 3fi0G-1a3xA:
undetectable		 3fi0G-1a3xA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 GLY A 229
ILE A  11
VAL A 270
GLN A  17
 None
 0.77A 3fi0G-1c3lA:
undetectable		 3fi0G-1c3lA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus) 		PF00248
(Aldo_ket_red) 		4 GLY A  55
ILE A  42
VAL A  31
VAL A  27
 None
 0.78A 3fi0G-1c9wA:
undetectable		 3fi0G-1c9wA:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		8 GLY A   7
VAL A  40
HIS A  43
ASP A 132
ILE A 133
VAL A 141
VAL A 143
GLN A 147
 None
 0.52A 3fi0G-1d2rA:
42.3		 3fi0G-1d2rA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		4 ASP A  37
ILE A 321
VAL A 282
VAL A 269
 None
 0.75A 3fi0G-1gzgA:
undetectable		 3fi0G-1gzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 VAL A 372
HIS A 347
ILE A 343
VAL A 415
VAL A 412
 None
 1.25A 3fi0G-1i7oA:
undetectable		 3fi0G-1i7oA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 GLY A  34
HIS A  70
ASP A 158
ILE A 159
 TYR  A 401 (-3.4A)
TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
 0.61A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		4 HIS A  70
ASP A 158
ILE A 159
GLN A 173
 TYR  A 401 (-3.5A)
TYR  A 401 (-3.5A)
None
TYR  A 401 (-3.0A)
 0.41A 3fi0G-1j1uA:
19.3		 3fi0G-1j1uA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 GLY A 388
ILE A 364
VAL A 367
VAL A 375
 None
 0.74A 3fi0G-1k32A:
undetectable		 3fi0G-1k32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		4 GLY A 106
ASP A  35
ILE A  34
VAL A  64
 None
 0.79A 3fi0G-1ntgA:
undetectable		 3fi0G-1ntgA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 GLY A1042
ILE A1056
VAL A1048
GLN A 501
 None
 0.73A 3fi0G-1ofeA:
undetectable		 3fi0G-1ofeA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 190
ILE A 183
VAL A 272
VAL A 296
 None
NAD  A 400 (-3.8A)
NAD  A 400 (-4.5A)
NAD  A 400 (-4.7A)
 0.76A 3fi0G-1pl8A:
2.6		 3fi0G-1pl8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  35
ILE A  36
VAL A 146
VAL A  93
 None
 0.76A 3fi0G-1q1nA:
undetectable		 3fi0G-1q1nA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sg9 HEMK PROTEIN

(Thermotoga
maritima) 		PF05175
(MTS) 		4 GLY A  23
ILE A  18
VAL A  36
VAL A  70
 None
 0.73A 3fi0G-1sg9A:
undetectable		 3fi0G-1sg9A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz0 HYPOTHETICAL PROTEIN

(Bacillus cereus) 		PF03992
(ABM) 		4 VAL A  13
HIS A  90
VAL A  56
VAL A  42
 None
 0.74A 3fi0G-1tz0A:
undetectable		 3fi0G-1tz0A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2h AORTIC
PREFERENTIALLY
EXPRESSED PROTEIN 1

(Homo sapiens) 		PF07679
(I-set) 		4 GLY A  34
ASP A  36
VAL A  31
VAL A 110
 None
 0.75A 3fi0G-1u2hA:
undetectable		 3fi0G-1u2hA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp5 TOPOISOMERASE IV

(Geobacillus
stearothermophilus) 		PF03989
(DNA_gyraseA_C) 		4 GLY A 251
ILE A 261
VAL A 210
GLN A 200
 None
 0.78A 3fi0G-1wp5A:
undetectable		 3fi0G-1wp5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfg GLUCOSAMINE--FRUCTOS
E-6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Escherichia
coli) 		PF13522
(GATase_6) 		4 GLY A  68
ILE A 189
VAL A 159
VAL A  96
 None
 0.71A 3fi0G-1xfgA:
undetectable		 3fi0G-1xfgA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9v GMP SYNTHASE

(Thermoplasma
acidophilum) 		PF00117
(GATase) 		4 GLY A 118
ASP A 178
ILE A 179
VAL A 109
 None
 0.66A 3fi0G-2a9vA:
undetectable		 3fi0G-2a9vA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az3 NUCLEOSIDE
DIPHOSPHATE KINASE

(Halobacterium
salinarum) 		PF00334
(NDK) 		4 GLY A  20
ASP A  24
ILE A  25
VAL A  12
 None
 0.74A 3fi0G-2az3A:
undetectable		 3fi0G-2az3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 GLY A  41
HIS A  77
ASP A 172
ILE A 173
 None
 0.51A 3fi0G-2cyaA:
21.3		 3fi0G-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 HIS A  77
ASP A 172
ILE A 173
GLN A 187
 None
None
None
SO4  A1003 (-3.9A)
 0.54A 3fi0G-2cyaA:
21.3		 3fi0G-2cyaA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 GLY A  38
HIS A  74
ASP A 165
ILE A 166
GLN A 180
 None
 0.81A 3fi0G-2cybA:
20.8		 3fi0G-2cybA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		5 GLY A   7
VAL A  42
ILE A 137
VAL A 145
VAL A 147
 None
 0.59A 3fi0G-2el7A:
33.0		 3fi0G-2el7A:
40.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2el7 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		4 VAL A  42
ASP A 136
ILE A 137
VAL A 145
 None
 0.77A 3fi0G-2el7A:
33.0		 3fi0G-2el7A:
40.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 GLY A 250
VAL A 204
VAL A  97
VAL A 129
 None
 0.76A 3fi0G-2f43A:
undetectable		 3fi0G-2f43A:
22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		6 GLY A   6
HIS A  43
ASP A 136
ILE A 137
VAL A 145
GLN A 151
 TRP  A 401 (-4.1A)
TRP  A 401 (-3.9A)
TRP  A 401 (-3.8A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
TRP  A 401 (-3.5A)
 0.41A 3fi0G-2g36A:
33.5		 3fi0G-2g36A:
37.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2g36 TRYPTOPHANYL-TRNA
SYNTHETASE

(Thermotoga
maritima) 		PF00579
(tRNA-synt_1b) 		5 HIS A  43
ILE A 137
VAL A 145
VAL A 147
GLN A 151
 TRP  A 401 (-3.9A)
TRP  A 401 (-4.9A)
TRP  A 401 (-4.7A)
None
TRP  A 401 (-3.5A)
 0.59A 3fi0G-2g36A:
33.5		 3fi0G-2g36A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipf (3(17)ALPHA-HYDROXYS
TEROID
DEHYDROGENASE)

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 GLY A  20
ILE A  16
VAL A 266
GLN A 190
 None
None
None
NAP  A   1 (-3.8A)
 0.68A 3fi0G-2ipfA:
undetectable		 3fi0G-2ipfA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 GLY A  55
ILE A  42
VAL A  31
VAL A  27
 None
 0.73A 3fi0G-2is7A:
undetectable		 3fi0G-2is7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n59 PUTATIVE
UNCHARACTERIZED
PROTEIN CSGH

(Rhodopseudomonas
palustris) 		no annotation 4 GLY A  29
ILE A  21
VAL A  81
VAL A  86
 None
 0.76A 3fi0G-2n59A:
undetectable		 3fi0G-2n59A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsi PUTATIVE HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HUPG

(Rhodopseudomonas
palustris) 		PF07449
(HyaE) 		4 GLY A  31
ILE A  27
VAL A  34
VAL A  67
 None
 0.69A 3fi0G-2qsiA:
undetectable		 3fi0G-2qsiA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yy5 TRYPTOPHANYL-TRNA
SYNTHETASE

(Mycoplasma
pneumoniae) 		PF00579
(tRNA-synt_1b) 		7 GLY A   8
HIS A  44
ASP A 140
ILE A 141
VAL A 149
VAL A 151
GLN A 155
 WSA  A1350 (-3.7A)
WSA  A1350 (-3.5A)
WSA  A1350 (-4.1A)
WSA  A1350 ( 4.9A)
None
WSA  A1350 ( 3.7A)
SO4  A1363 ( 3.2A)
 0.45A 3fi0G-2yy5A:
35.7		 3fi0G-2yy5A:
40.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoo PROBABLE NITRITE
REDUCTASE

(Pseudoalteromonas
haloplanktis) 		PF00034
(Cytochrom_C)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 GLY A  67
ILE A  70
VAL A  64
VAL A 144
 None
 0.72A 3fi0G-2zooA:
undetectable		 3fi0G-2zooA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		4 GLY A 206
ASP A 183
ILE A 184
VAL A 210
 None
None
None
A5A  A 801 (-4.8A)
 0.73A 3fi0G-2ztgA:
undetectable		 3fi0G-2ztgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zua NUCLEOSIDE
DIPHOSPHATE KINASE

(Haloarcula
quadrata) 		PF00334
(NDK) 		4 GLY A  19
ASP A  23
ILE A  24
VAL A  11
 None
 0.74A 3fi0G-2zuaA:
undetectable		 3fi0G-2zuaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a05 TRYPTOPHANYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 GLY A  76
ASP A 195
ILE A 196
VAL A 212
 TRP  A 377 (-3.6A)
TRP  A 377 (-3.6A)
None
None
 0.39A 3fi0G-3a05A:
23.0		 3fi0G-3a05A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ASP A 337
ILE A 338
VAL A 235
GLN A 233
 None
 0.73A 3fi0G-3bfjA:
undetectable		 3fi0G-3bfjA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce1 SUPEROXIDE DISMUTASE
[CU-ZN]

(Naganishia
liquefaciens) 		PF00080
(Sod_Cu) 		4 VAL A  17
ILE A  21
VAL A 101
VAL A  91
 None
 0.65A 3fi0G-3ce1A:
undetectable		 3fi0G-3ce1A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.69A 3fi0G-3iayA:
undetectable		 3fi0G-3iayA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3idu UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF07705
(CARDB) 		4 GLY A 446
ILE A 513
VAL A 537
VAL A 450
 None
 0.69A 3fi0G-3iduA:
undetectable		 3fi0G-3iduA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9u V-TYPE PROTON ATPASE
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C 336
VAL C 281
VAL C  94
VAL C 217
 None
 0.72A 3fi0G-3j9uC:
undetectable		 3fi0G-3j9uC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrr INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 3

(Mus musculus) 		PF08709
(Ins145_P3_rec) 		4 GLY A 119
ILE A 122
VAL A 116
VAL A 177
 None
 0.62A 3fi0G-3jrrA:
undetectable		 3fi0G-3jrrA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		4 VAL A  89
ASP A  87
ILE A 112
VAL A 140
 None
 0.73A 3fi0G-3k53A:
undetectable		 3fi0G-3k53A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krb ALDOSE REDUCTASE

(Giardia
intestinalis) 		PF00248
(Aldo_ket_red) 		4 GLY A  47
ILE A  34
VAL A  23
VAL A  19
 None
 0.74A 3fi0G-3krbA:
undetectable		 3fi0G-3krbA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		6 GLY A   6
HIS A  42
ASP A 131
ILE A 132
VAL A 140
GLN A 146
 None
 0.54A 3fi0G-3m5wA:
33.4		 3fi0G-3m5wA:
39.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00579
(tRNA-synt_1b) 		6 GLY A   6
HIS A  42
ILE A 132
VAL A 140
VAL A 142
GLN A 146
 None
 0.47A 3fi0G-3m5wA:
33.4		 3fi0G-3m5wA:
39.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7n PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Archaeoglobus
fulgidus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 GLY D  58
ASP D 124
ILE D 125
VAL D 153
 None
 0.66A 3fi0G-3m7nD:
undetectable		 3fi0G-3m7nD:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9i TRYPTOPHANYL-TRNA
SYNTHETASE

(Yersinia pestis) 		PF00579
(tRNA-synt_1b) 		7 GLY A  21
VAL A  54
HIS A  57
ASP A 147
ILE A 148
VAL A 156
GLN A 162
 GOL  A1001 (-3.6A)
GOL  A1001 (-4.6A)
GOL  A1001 ( 4.7A)
GOL  A1001 (-3.9A)
None
None
None
 0.34A 3fi0G-3n9iA:
39.3		 3fi0G-3n9iA:
54.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntv MW1564 PROTEIN

(Staphylococcus
aureus) 		PF01596
(Methyltransf_3) 		4 GLY A 181
ASP A 185
ILE A 188
VAL A 198
 None
 0.77A 3fi0G-3ntvA:
undetectable		 3fi0G-3ntvA:
22.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		6 GLY A   8
VAL A  41
HIS A  44
ASP A 133
ILE A 134
GLN A 148
 None
 0.49A 3fi0G-3prhA:
40.8		 3fi0G-3prhA:
69.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3prh TRYPTOPHANYL-TRNA
SYNTHETASE

(Bacillus
subtilis) 		PF00579
(tRNA-synt_1b) 		6 GLY A   8
VAL A  41
HIS A  44
ASP A 133
ILE A 134
VAL A 142
 None
 0.43A 3fi0G-3prhA:
40.8		 3fi0G-3prhA:
69.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pua PHD FINGER PROTEIN 2

(Homo sapiens) 		PF02373
(JmjC) 		4 GLY A 134
ASP A 210
ILE A 211
VAL A 129
 EDO  A   6 (-4.5A)
EDO  A   6 ( 4.8A)
None
None
 0.76A 3fi0G-3puaA:
undetectable		 3fi0G-3puaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4g NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Vibrio cholerae) 		PF02540
(NAD_synthase) 		4 GLY A 160
ILE A 155
VAL A  41
GLN A  74
 None
 0.68A 3fi0G-3q4gA:
2.6		 3fi0G-3q4gA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLY A 779
ASP A 745
ILE A 744
VAL A 808
 None
 0.74A 3fi0G-3qdeA:
undetectable		 3fi0G-3qdeA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 226
VAL A 189
ILE A 244
VAL A 255
 None
 0.77A 3fi0G-3sn0A:
undetectable		 3fi0G-3sn0A:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		5 ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 401 (-4.0A)
None
TRP  A 401 (-4.9A)
None
TRP  A 401 (-3.8A)
 1.26A 3fi0G-3sz3A:
38.5		 3fi0G-3sz3A:
52.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		6 GLY A   9
VAL A  42
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 401 (-3.8A)
TRP  A 401 (-4.7A)
TRP  A 401 (-4.0A)
None
TRP  A 401 (-4.9A)
None
 0.62A 3fi0G-3sz3A:
38.5		 3fi0G-3sz3A:
52.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		4 GLY A 167
ILE A 194
VAL A  35
VAL A  27
 None
 0.68A 3fi0G-3ufaA:
undetectable		 3fi0G-3ufaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		4 GLY A 844
ASP A 842
VAL A 849
VAL A 895
 None
 0.66A 3fi0G-3ujzA:
undetectable		 3fi0G-3ujzA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcy INTERFERON
ALPHA/BETA RECEPTOR
1

(Mus musculus) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 GLY A 276
ASP A 300
ILE A 299
GLN A 270
 None
 0.71A 3fi0G-3wcyA:
undetectable		 3fi0G-3wcyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  79
ILE A  82
VAL A  76
VAL A 154
 None
 0.77A 3fi0G-3wiaA:
undetectable		 3fi0G-3wiaA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		4 GLY A 206
ASP A 183
ILE A 184
VAL A 210
 None
 0.78A 3fi0G-3wqyA:
undetectable		 3fi0G-3wqyA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b62 TSSL1

(Pseudomonas
aeruginosa) 		PF00691
(OmpA) 		4 VAL A 365
ILE A 358
VAL A 332
VAL A 323
 None
 0.79A 3fi0G-4b62A:
undetectable		 3fi0G-4b62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		4 GLY A 782
VAL A 253
VAL A 763
VAL A 787
 None
 0.77A 3fi0G-4ci8A:
undetectable		 3fi0G-4ci8A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dq7 MEMBRANE PROTEIN
PHI6 P5

(Pseudomonas
virus phi6) 		PF10464
(Peptidase_U40) 		4 GLY A 102
VAL A  99
ILE A  92
VAL A  70
 None
 0.79A 3fi0G-4dq7A:
undetectable		 3fi0G-4dq7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 ILE A 254
VAL A 376
VAL A 264
GLN A 244
 None
 0.74A 3fi0G-4eyoA:
2.0		 3fi0G-4eyoA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 283
ILE A 290
VAL A 280
VAL A 543
 FED  A 801 (-3.5A)
FED  A 801 (-4.9A)
None
None
 0.79A 3fi0G-4h7uA:
undetectable		 3fi0G-4h7uA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2o FIXK2 PROTEIN

(Bradyrhizobium
japonicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A 192
HIS A 148
ILE A 187
VAL A 198
 None
 0.71A 3fi0G-4i2oA:
undetectable		 3fi0G-4i2oA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3o OUTER MEMBRANE USHER
PROTEIN FIMD

(Escherichia
coli) 		PF00577
(Usher)
PF13953
(PapC_C)
PF13954
(PapC_N) 		4 VAL D 280
ILE D 256
VAL D 301
GLN D 311
 None
 0.76A 3fi0G-4j3oD:
undetectable		 3fi0G-4j3oD:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l3a INTERNALIN K

(Listeria
monocytogenes) 		no annotation 4 ASP A 385
ILE A 386
VAL A 431
VAL A 414
 None
 0.78A 3fi0G-4l3aA:
undetectable		 3fi0G-4l3aA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lh7 DNA LIGASE

(Enterococcus
faecalis) 		PF01653
(DNA_ligase_aden) 		4 GLY A 233
ILE A 168
VAL A 170
VAL A 229
 None
 0.64A 3fi0G-4lh7A:
undetectable		 3fi0G-4lh7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 VAL B 249
ILE B 242
VAL B 279
VAL B 225
 None
None
CL  B 402 (-3.8A)
None
 0.69A 3fi0G-4lrsB:
undetectable		 3fi0G-4lrsB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		4 GLY A 143
VAL A 216
ASP A 214
ILE A 211
 None
 0.71A 3fi0G-4ns4A:
undetectable		 3fi0G-4ns4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ry9 PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Verminephrobacter
eiseniae) 		PF13407
(Peripla_BP_4) 		4 GLY A 232
VAL A 238
ILE A 162
VAL A 181
 None
 0.66A 3fi0G-4ry9A:
undetectable		 3fi0G-4ry9A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		4 GLY A 660
ASP A 658
ILE A 657
VAL A 771
 None
 0.77A 3fi0G-4txgA:
undetectable		 3fi0G-4txgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh7 MULTIPLE PDZ DOMAIN
PROTEIN

(Mus musculus) 		PF00595
(PDZ) 		4 GLY A 557
ILE A 560
VAL A 580
VAL A 549
 None
 0.75A 3fi0G-4xh7A:
undetectable		 3fi0G-4xh7A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Bordetella
bronchiseptica) 		PF01522
(Polysacc_deac_1) 		4 VAL A 139
HIS A 189
ASP A 114
VAL A 159
 None
NI  A 401 ( 3.3A)
NI  A 401 (-2.5A)
None
 0.76A 3fi0G-5bu6A:
undetectable		 3fi0G-5bu6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 GLY A 156
ASP A 105
VAL A 128
VAL A 131
 None
 0.78A 3fi0G-5d3mA:
undetectable		 3fi0G-5d3mA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		4 HIS A 284
ILE A 327
VAL A 343
GLN A 306
 None
 0.71A 3fi0G-5d9nA:
undetectable		 3fi0G-5d9nA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Xenopus
tropicalis) 		PF04096
(Nucleoporin2) 		4 VAL B 767
ILE B 753
VAL B 778
VAL B 787
 None
 0.75A 3fi0G-5e0qB:
undetectable		 3fi0G-5e0qB:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ekd TRYPTOPHAN--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		8 GLY A  40
VAL A  74
HIS A  77
ASP A 167
ILE A 168
VAL A 176
VAL A 178
GLN A 182
 5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
5BX  A 401 (-3.5A)
5BX  A 401 (-3.9A)
5BX  A 401 ( 4.9A)
None
ATP  A 402 (-3.2A)
5BX  A 401 ( 3.0A)
 0.48A 3fi0G-5ekdA:
36.5		 3fi0G-5ekdA:
40.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9q MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN YKNZ

(Bacillus
amyloliquefaciens) 		PF12704
(MacB_PCD) 		4 GLY A 193
VAL A 212
VAL A  52
VAL A  55
 None
 0.70A 3fi0G-5f9qA:
undetectable		 3fi0G-5f9qA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 VAL E 102
ILE E  95
VAL E  80
VAL E 128
 None
 0.74A 3fi0G-5g06E:
undetectable		 3fi0G-5g06E:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gru DIABODY PROTEIN
DIABODY PROTEIN

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		4 GLY L 109
ILE L  38
VAL H 178
GLN H 172
 GLY  L 109 ( 0.0A)
ILE  L  38 ( 0.7A)
VAL  H 178 ( 0.6A)
GLN  H 172 ( 0.6A)
 0.63A 3fi0G-5gruL:
undetectable		 3fi0G-5gruL:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jos CYCLOHEXADIENYL
DEHYDRATASE

(synthetic
construct) 		PF00497
(SBP_bac_3) 		4 ASP A 128
ILE A 129
VAL A 177
VAL A 115
 None
 0.71A 3fi0G-5josA:
undetectable		 3fi0G-5josA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 VAL A 109
ILE A 150
VAL A 153
VAL A 192
 None
None
None
FAD  A 401 (-3.7A)
 0.76A 3fi0G-5jzxA:
undetectable		 3fi0G-5jzxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 GLY A 450
ILE A 481
VAL A 457
VAL A 427
 None
 0.76A 3fi0G-5n8pA:
undetectable		 3fi0G-5n8pA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		4 GLY A 450
ILE A 481
VAL A 457
VAL A 427
 None
 0.76A 3fi0G-5n97A:
undetectable		 3fi0G-5n97A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Homo sapiens) 		no annotation 4 GLY A 133
ILE A 112
VAL A   5
VAL A 151
 None
 0.79A 3fi0G-5oshA:
undetectable		 3fi0G-5oshA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		5 GLY A   9
HIS A  47
ASP A 145
ILE A 146
VAL A 154
 None
 0.31A 3fi0G-5tevA:
33.6		 3fi0G-5tevA:
33.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tev TRYPTOPHAN--TRNA
LIGASE

(Neisseria
gonorrhoeae) 		PF00579
(tRNA-synt_1b) 		5 GLY A   9
HIS A  47
ILE A 146
VAL A 154
VAL A 156
 None
 0.49A 3fi0G-5tevA:
33.6		 3fi0G-5tevA:
33.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Trypanosoma
brucei) 		PF01536
(SAM_decarbox) 		4 VAL A 119
ILE A 112
VAL A  95
VAL A  90
 None
 0.73A 3fi0G-5tvoA:
undetectable		 3fi0G-5tvoA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		7 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.31A 3fi0G-5v0iA:
40.0		 3fi0G-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		6 HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.57A 3fi0G-5v0iA:
40.0		 3fi0G-5v0iA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx1 SERINE PROTEASE NS3

(Pestivirus C) 		PF00271
(Helicase_C)
PF05578
(Peptidase_S31)
PF07652
(Flavi_DEAD) 		4 GLY A 164
VAL A  67
ILE A 167
VAL A 117
 None
 0.66A 3fi0G-5wx1A:
undetectable		 3fi0G-5wx1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcx VL-SARAH(S37C)
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 HIS B  34
ILE B  29
VAL B  25
VAL B   4
 None
 0.76A 3fi0G-5xcxB:
undetectable		 3fi0G-5xcxB:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xlk FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Serratia
marcescens) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		4 GLY A 135
ILE A 132
VAL A 166
GLN A 105
 None
 0.73A 3fi0G-5xlkA:
undetectable		 3fi0G-5xlkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 4 GLY A 246
ASP A 248
ILE A 249
VAL A 197
 None
 0.72A 3fi0G-5zctA:
undetectable		 3fi0G-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dfu TRYPTOPHAN--TRNA
LIGASE

(Haemophilus
influenzae) 		no annotation 8 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.62A 3fi0G-6dfuA:
40.1		 3fi0G-6dfuA:
undetectable