SIMILAR PATTERNS OF AMINO ACIDS FOR 3FHX_B_PXLB313

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.07A 3fhxB-1d6hA:
undetectable		 3fhxB-1d6hA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 SER B2113
VAL B2043
THR B2129
VAL B2172
 None
 1.14A 3fhxB-1e6yB:
undetectable		 3fhxB-1e6yB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 VAL A 490
PHE A 492
THR A 526
VAL A  34
 None
 1.15A 3fhxB-1kb0A:
undetectable		 3fhxB-1kb0A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcm PHOSPHATIDYLINOSITOL
TRANSFER PROTEIN
ALPHA

(Mus musculus) 		PF02121
(IP_trans) 		4 VAL A 199
PHE A 213
HIS A 215
VAL A 197
 None
 0.99A 3fhxB-1kcmA:
undetectable		 3fhxB-1kcmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 VAL A  55
THR A  95
TYR A  35
VAL A  52
 None
 0.78A 3fhxB-1l1lA:
undetectable		 3fhxB-1l1lA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 SER A 141
VAL A 139
THR A 198
VAL A 152
 None
 0.89A 3fhxB-1pojA:
2.3		 3fhxB-1pojA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		5 SER A  12
PHE A  43
HIS A  46
THR A  47
VAL A 231
 None
 0.75A 3fhxB-1rfvA:
47.7		 3fhxB-1rfvA:
86.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		6 VAL A  19
PHE A  43
HIS A  46
THR A  47
TYR A  84
VAL A 231
 None
 0.53A 3fhxB-1rfvA:
47.7		 3fhxB-1rfvA:
86.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		6 VAL A  19
VAL A  41
PHE A  43
HIS A  46
THR A  47
VAL A 231
 None
 0.49A 3fhxB-1rfvA:
47.7		 3fhxB-1rfvA:
86.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4d UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Pseudomonas
denitrificans
(nomen
rejiciendum)) 		PF00590
(TP_methylase) 		4 VAL A 249
VAL A 243
PHE A 209
THR A 223
 None
 0.93A 3fhxB-1s4dA:
undetectable		 3fhxB-1s4dA:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		5 VAL A  39
PHE A  41
HIS A  44
THR A  45
VAL A 220
 None
None
PXL  A 288 (-4.9A)
PXL  A 288 (-2.7A)
PXL  A 288 (-4.5A)
 0.51A 3fhxB-1td2A:
37.3		 3fhxB-1td2A:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 345
VAL A 372
PHE A 374
HIS A 306
 None
 0.99A 3fhxB-1u0uA:
undetectable		 3fhxB-1u0uA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.01A 3fhxB-1z1eA:
undetectable		 3fhxB-1z1eA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z77 TRANSCRIPTIONAL
REGULATOR (TETR
FAMILY)

(Thermotoga
maritima) 		PF00440
(TetR_N) 		4 VAL A 187
PHE A 158
TYR A 165
VAL A 184
 None
 1.02A 3fhxB-1z77A:
undetectable		 3fhxB-1z77A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr4 TRANSPOSON
GAMMA-DELTA
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		4 VAL A  60
VAL A  63
PHE A  92
THR A  99
 None
 1.04A 3fhxB-1zr4A:
2.0		 3fhxB-1zr4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 VAL A 222
VAL A 213
PHE A 190
VAL A 226
 None
 0.94A 3fhxB-2csuA:
3.1		 3fhxB-2csuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		4 VAL A 110
VAL A  25
THR A  40
VAL A  48
 None
 0.97A 3fhxB-2cvhA:
2.9		 3fhxB-2cvhA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		4 SER A 195
VAL A 193
PHE A 226
VAL A 190
 None
None
SAM  A 400 (-4.9A)
None
 0.99A 3fhxB-2f8lA:
2.7		 3fhxB-2f8lA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gx8 NIF3-RELATED PROTEIN

(Bacillus cereus) 		PF01784
(NIF3) 		4 VAL A 142
VAL A 216
HIS A 224
VAL A 144
 None
 1.02A 3fhxB-2gx8A:
undetectable		 3fhxB-2gx8A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 VAL A 638
PHE A 557
HIS A 641
VAL A 799
 None
 1.05A 3fhxB-2hg4A:
undetectable		 3fhxB-2hg4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 407
VAL A 424
PHE A 422
VAL A 290
 None
 1.00A 3fhxB-2htvA:
undetectable		 3fhxB-2htvA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jtc STREPTOPAIN

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10) 		4 VAL A 157
PHE A 151
THR A  52
VAL A 248
 None
 1.11A 3fhxB-2jtcA:
undetectable		 3fhxB-2jtcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 VAL A  73
HIS A  76
THR A  82
VAL A   8
 None
 1.09A 3fhxB-2livA:
2.8		 3fhxB-2livA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 382
VAL A 378
THR A 336
VAL A 306
 None
 1.00A 3fhxB-2nztA:
undetectable		 3fhxB-2nztA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8d PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE 2

(Bacillus
subtilis) 		PF00884
(Sulfatase) 		4 VAL A 503
VAL A 526
HIS A 290
TYR A 469
 None
 0.98A 3fhxB-2w8dA:
undetectable		 3fhxB-2w8dA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 VAL A 144
VAL A 161
TYR A 128
VAL A 136
 None
 1.11A 3fhxB-2w8iA:
undetectable		 3fhxB-2w8iA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 414
VAL A 388
TYR A 412
VAL A 433
 None
 1.11A 3fhxB-2xtlA:
undetectable		 3fhxB-2xtlA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 335
VAL A 362
PHE A 364
HIS A 296
 None
 1.02A 3fhxB-3a5rA:
undetectable		 3fhxB-3a5rA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		4 VAL A 206
VAL A   5
HIS A  15
VAL A 202
 None
 1.11A 3fhxB-3aw9A:
2.3		 3fhxB-3aw9A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcq BETA-CHAIN
HEMOGLOBIN

(Brycon cephalus) 		PF00042
(Globin) 		4 VAL B  60
HIS B  41
THR B  38
VAL B  98
 None
HEM  B 147 (-4.3A)
HEM  B 147 (-4.0A)
HEM  B 147 (-4.3A)
 1.05A 3fhxB-3bcqB:
undetectable		 3fhxB-3bcqB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		4 VAL A  40
VAL A  96
PHE A 188
HIS A 186
 None
None
None
GOL  A 524 (-3.5A)
 1.06A 3fhxB-3fotA:
undetectable		 3fhxB-3fotA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		4 VAL A 119
PHE A 114
HIS A 116
VAL A  93
 None
 1.13A 3fhxB-3hzuA:
undetectable		 3fhxB-3hzuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 VAL 3   6
VAL 3  30
PHE 3  24
VAL 3   4
 None
 1.01A 3fhxB-3i9v3:
3.2		 3fhxB-3i9v3:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l57 MOBILIZATION PROTEIN
TRAI

(Escherichia
coli) 		PF08751
(TrwC) 		4 VAL A 117
HIS A 162
THR A 161
VAL A  16
 None
MN3  A 300 ( 3.3A)
None
None
 0.69A 3fhxB-3l57A:
undetectable		 3fhxB-3l57A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 VAL A 130
VAL A 124
PHE A  96
THR A 144
 None
 0.99A 3fhxB-3nnkA:
undetectable		 3fhxB-3nnkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		4 VAL A 453
VAL A 425
TYR A 417
VAL A 394
 None
 0.90A 3fhxB-3o8oA:
undetectable		 3fhxB-3o8oA:
17.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pzs PYRIDOXAMINE KINASE

(Yersinia pestis) 		PF08543
(Phos_pyr_kin) 		7 SER A   9
VAL A  38
PHE A  40
HIS A  43
THR A  44
TYR A  82
VAL A 219
 None
None
BME  A 290 (-4.2A)
None
None
None
SO4  A 288 (-3.6A)
 0.59A 3fhxB-3pzsA:
40.4		 3fhxB-3pzsA:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q06 CELLULAR TUMOR
ANTIGEN P53

(Homo sapiens) 		PF00870
(P53)
PF07710
(P53_tetramer) 		4 VAL A 135
VAL A 143
PHE A 234
VAL A 274
 None
 0.75A 3fhxB-3q06A:
undetectable		 3fhxB-3q06A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		4 SER A 214
VAL A 218
VAL A 242
THR A 298
 None
None
None
EDO  A 405 ( 4.4A)
 1.13A 3fhxB-3s2jA:
2.8		 3fhxB-3s2jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Thermomonospora
curvata) 		PF10021
(DUF2263) 		4 SER A 120
VAL A 157
THR A  76
VAL A 172
 None
None
AR6  A 280 (-4.3A)
None
 1.15A 3fhxB-3sigA:
undetectable		 3fhxB-3sigA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 363
VAL A 371
TYR A 354
VAL A 134
 None
 1.03A 3fhxB-3t9pA:
undetectable		 3fhxB-3t9pA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 VAL A 929
VAL A 956
PHE A 958
HIS A 890
 None
 1.01A 3fhxB-3tsyA:
undetectable		 3fhxB-3tsyA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		4 VAL A  69
VAL A   6
HIS A 340
VAL A 301
 None
 1.02A 3fhxB-3us8A:
4.5		 3fhxB-3us8A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 VAL A 275
VAL A 338
PHE A 334
VAL A 293
 None
 1.15A 3fhxB-3v7nA:
undetectable		 3fhxB-3v7nA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 VAL A 869
HIS A 866
THR A 864
VAL A 837
 None
 1.11A 3fhxB-3w5nA:
undetectable		 3fhxB-3w5nA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 VAL  A 342 ( 0.6A)
VAL  A 369 ( 0.6A)
PHE  A 371 ( 1.3A)
HIS  A 303 ( 1.0A)
 1.02A 3fhxB-3wd7A:
undetectable		 3fhxB-3wd7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.04A 3fhxB-3wd8A:
undetectable		 3fhxB-3wd8A:
20.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 VAL A  18
VAL A  40
HIS A  45
TYR A  84
 None
 0.60A 3fhxB-3zs7A:
36.8		 3fhxB-3zs7A:
39.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af5 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR ACNR
COMPND 2

(Corynebacterium
glutamicum) 		PF00440
(TetR_N) 		4 VAL A 180
PHE A 152
HIS A 150
VAL A 127
 None
 1.16A 3fhxB-4af5A:
undetectable		 3fhxB-4af5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF01344
(Kelch_1) 		4 VAL A 457
VAL A 352
PHE A 405
VAL A 464
 None
 1.06A 3fhxB-4ascA:
undetectable		 3fhxB-4ascA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjp PENICILLIN BINDING
PROTEIN
TRANSPEPTIDASE
DOMAIN PROTEIN

(Escherichia
coli) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 VAL A 529
VAL A 272
THR A 298
VAL A 531
 None
None
None
GOL  A 623 (-4.7A)
 1.14A 3fhxB-4bjpA:
undetectable		 3fhxB-4bjpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bq4 B-AGARASE

(Saccharophagus
degradans) 		PF02449
(Glyco_hydro_42) 		4 SER A 729
PHE A 736
TYR A 726
VAL A 781
 None
 1.10A 3fhxB-4bq4A:
undetectable		 3fhxB-4bq4A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cq6 ALLENE OXIDE CYCLASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06351
(Allene_ox_cyc) 		4 VAL A  77
VAL A  73
PHE A  85
THR A 107
 None
 1.08A 3fhxB-4cq6A:
undetectable		 3fhxB-4cq6A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 VAL A 642
PHE A 681
HIS A 683
VAL A 761
 None
 1.10A 3fhxB-4dloA:
undetectable		 3fhxB-4dloA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN

(Eleginops
maclovinus) 		PF00042
(Globin) 		4 VAL B  60
HIS B  41
THR B  38
VAL B  98
 None
HEM  B 202 (-4.4A)
HEM  B 202 (-3.8A)
HEM  B 202 ( 4.6A)
 1.15A 3fhxB-4esaB:
undetectable		 3fhxB-4esaB:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 SER A  74
VAL A 147
VAL A  73
VAL A 103
 None
 1.10A 3fhxB-4ewgA:
undetectable		 3fhxB-4ewgA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 SER A 382
VAL A 378
THR A 336
VAL A 306
 None
 1.02A 3fhxB-4f9oA:
undetectable		 3fhxB-4f9oA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcx ISOCITRATE
DEHYDROGENASE [NADP]

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		4 VAL A  72
VAL A   9
HIS A 345
VAL A 306
 None
 0.96A 3fhxB-4hcxA:
3.4		 3fhxB-4hcxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hht RIBONUCLEASE HII

(Thermotoga
maritima) 		PF01351
(RNase_HII) 		4 SER A 184
VAL A 188
HIS A 181
VAL A 177
 None
 1.12A 3fhxB-4hhtA:
undetectable		 3fhxB-4hhtA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF07504
(FTP) 		4 VAL B 118
VAL B  86
HIS B  74
VAL B 126
 None
 0.74A 3fhxB-4k90B:
undetectable		 3fhxB-4k90B:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00215
(OMPdecase) 		4 VAL A  47
VAL A 208
TYR A 227
VAL A  43
 None
 0.82A 3fhxB-4lujA:
undetectable		 3fhxB-4lujA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o59 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bos taurus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 VAL O   3
PHE O  20
THR O  16
VAL O  93
 None
 1.15A 3fhxB-4o59O:
3.8		 3fhxB-4o59O:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1b TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN B

(Pseudomonas
mendocina) 		PF06234
(TmoB) 		4 VAL C  19
VAL C  80
PHE C  10
HIS C  37
 None
 0.74A 3fhxB-4p1bC:
undetectable		 3fhxB-4p1bC:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL A  77
VAL A  83
HIS A  56
VAL A 112
 None
 1.04A 3fhxB-4p72A:
2.4		 3fhxB-4p72A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 VAL A 239
VAL A 254
HIS A 236
VAL A  65
 None
 1.04A 3fhxB-4pxlA:
undetectable		 3fhxB-4pxlA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 VAL A  32
THR A  90
TYR A 120
VAL A  30
 None
 0.90A 3fhxB-4tnwA:
undetectable		 3fhxB-4tnwA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uyp CELLULOSOMAL
SCAFFOLDIN ANCHORING
PROTEIN C

(Acetivibrio
cellulolyticus) 		PF00963
(Cohesin) 		4 VAL A  19
VAL A  47
PHE A  40
THR A  38
 None
 1.14A 3fhxB-4uypA:
undetectable		 3fhxB-4uypA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.07A 3fhxB-4wumA:
undetectable		 3fhxB-4wumA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A  95
THR A  68
TYR A  97
VAL A 103
 None
 1.05A 3fhxB-4wy5A:
2.8		 3fhxB-4wy5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 345
VAL A 372
PHE A 374
HIS A 306
 None
 1.02A 3fhxB-4yjyA:
undetectable		 3fhxB-4yjyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		4 VAL A 219
VAL A   5
HIS A  15
VAL A 215
 None
 1.01A 3fhxB-4zrmA:
2.7		 3fhxB-4zrmA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n AMINOACYL TRNA
SYNTHASE
COMPLEX-INTERACTING
MULTIFUNCTIONAL
PROTEIN 2

(Homo sapiens) 		PF00043
(GST_C) 		4 SER B 219
VAL B 276
PHE B 216
VAL B 237
 None
 1.11A 3fhxB-5a1nB:
undetectable		 3fhxB-5a1nB:
24.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		6 SER A  12
PHE A  43
HIS A  46
THR A  47
TYR A  85
VAL A 221
 TRS  A 301 (-3.1A)
TRS  A 301 ( 4.8A)
None
TRS  A 301 (-3.0A)
TRS  A 301 (-4.3A)
None
 0.46A 3fhxB-5b6aA:
39.5		 3fhxB-5b6aA:
31.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b6a PYRIDOXAL KINASE
PDXY

(Pseudomonas
aeruginosa) 		PF08543
(Phos_pyr_kin) 		6 SER A  12
VAL A  41
PHE A  43
HIS A  46
THR A  47
VAL A 221
 TRS  A 301 (-3.1A)
None
TRS  A 301 ( 4.8A)
None
TRS  A 301 (-3.0A)
None
 0.58A 3fhxB-5b6aA:
39.5		 3fhxB-5b6aA:
31.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 VAL A 287
PHE A 231
HIS A 236
TYR A 238
 None
 0.89A 3fhxB-5dl5A:
undetectable		 3fhxB-5dl5A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		4 VAL A 997
VAL A1012
THR A1019
VAL A 469
 None
 1.09A 3fhxB-5dotA:
4.4		 3fhxB-5dotA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		4 VAL C 340
VAL C 378
PHE C 343
HIS C 342
 None
 1.04A 3fhxB-5exrC:
undetectable		 3fhxB-5exrC:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF12888
(Lipid_bd) 		4 VAL E 102
VAL E  21
THR E  45
TYR E 120
 None
 0.98A 3fhxB-5fq6E:
undetectable		 3fhxB-5fq6E:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		4 VAL A 126
HIS A 123
TYR A 154
VAL A  52
 None
 1.03A 3fhxB-5fshA:
4.1		 3fhxB-5fshA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fus PUTATIVE ENOYL COA
HYDRATASE

(Burkholderia
cenocepacia) 		PF00378
(ECH_1) 		4 VAL A 146
VAL A 173
TYR A 197
VAL A 128
 None
 0.89A 3fhxB-5fusA:
undetectable		 3fhxB-5fusA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		4 VAL C 248
PHE C  97
HIS C 204
VAL C 245
 UNL  C 308 ( 4.5A)
None
None
None
 1.13A 3fhxB-5iy5C:
undetectable		 3fhxB-5iy5C:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1t TORSIN-1A

(Homo sapiens) 		PF06309
(Torsin) 		4 SER A 243
VAL A 244
PHE A 245
HIS A 238
 None
 0.94A 3fhxB-5j1tA:
undetectable		 3fhxB-5j1tA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxq GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
1

(Mus musculus) 		PF10250
(O-FucT) 		4 SER A 310
VAL A 335
HIS A 234
TYR A 239
 None
 0.97A 3fhxB-5kxqA:
2.0		 3fhxB-5kxqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ney FUCOSE-BINDING
LECTIN II (PA-IIL)

(Pseudomonas
aeruginosa) 		PF07472
(PA-IIL) 		4 VAL A  28
VAL A  49
PHE A  19
VAL A  65
 None
 0.81A 3fhxB-5neyA:
undetectable		 3fhxB-5neyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 4 VAL A  25
VAL A  18
TYR A 128
VAL A  28
 None
 0.73A 3fhxB-5o0jA:
14.6		 3fhxB-5o0jA:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5trw PYRIDOXAL KINASE
PDXY

(Paraburkholderia
xenovorans) 		PF08543
(Phos_pyr_kin) 		6 VAL A  39
PHE A  41
HIS A  44
THR A  45
TYR A  83
VAL A 218
 None
 0.46A 3fhxB-5trwA:
38.1		 3fhxB-5trwA:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 VAL A 342
VAL A 369
PHE A 371
HIS A 303
 None
 1.04A 3fhxB-5uc5A:
undetectable		 3fhxB-5uc5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucm PROLINE--TRNA LIGASE

(Pseudomonas
aeruginosa) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 VAL A 113
HIS A 110
THR A 109
TYR A 419
 None
 0.99A 3fhxB-5ucmA:
undetectable		 3fhxB-5ucmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wix P-47 PROTEIN

(Clostridium
botulinum) 		no annotation 4 VAL A 303
THR A 306
TYR A 279
VAL A 362
 None
 1.06A 3fhxB-5wixA:
undetectable		 3fhxB-5wixA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		4 VAL A 453
PHE A 395
HIS A 391
VAL A 468
 None
 1.01A 3fhxB-5wu6A:
undetectable		 3fhxB-5wu6A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 336
VAL A 363
PHE A 365
HIS A 297
 None
 1.08A 3fhxB-5wx3A:
undetectable		 3fhxB-5wx3A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx4 ALKYLQUINOLONE
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 348
VAL A 375
PHE A 377
HIS A 309
 None
 1.04A 3fhxB-5wx4A:
undetectable		 3fhxB-5wx4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2q TASTE RECEPTOR, TYPE
1, MEMBER 2A

(Oryzias latipes) 		PF01094
(ANF_receptor) 		4 VAL A 369
PHE A  76
TYR A 374
VAL A 137
 None
NAG  A 901 (-4.1A)
None
None
 1.15A 3fhxB-5x2qA:
undetectable		 3fhxB-5x2qA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 4 VAL B  12
VAL B  55
PHE B  66
VAL B  22
 None
 0.96A 3fhxB-5y58B:
undetectable		 3fhxB-5y58B:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z97 LACTONASE FOR
PROTEIN

(Rhinocladiella
mackenziei) 		no annotation 4 VAL A 213
VAL A 227
PHE A 223
THR A 219
 None
 1.15A 3fhxB-5z97A:
undetectable		 3fhxB-5z97A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 VAL A 343
VAL A 370
PHE A 372
HIS A 304
 None
 1.00A 3fhxB-6co0A:
undetectable		 3fhxB-6co0A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cqb CHALCONE SYNTHASE

(Piper
methysticum) 		no annotation 4 VAL A 343
VAL A 370
PHE A 372
HIS A 304
 None
 1.01A 3fhxB-6cqbA:
undetectable		 3fhxB-6cqbA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 VAL A 481
VAL A 442
PHE A 505
VAL A 580
 None
 1.11A 3fhxB-6d4jA:
undetectable		 3fhxB-6d4jA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 4 VAL B 193
VAL B  40
HIS B 481
THR B 478
 None
 1.06A 3fhxB-6exvB:
undetectable		 3fhxB-6exvB:
15.02