SIMILAR PATTERNS OF AMINO ACIDS FOR 3FGR_B_ACTB21_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxn PROTEIN (RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN)


(Cupriavidus
necator)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ARG A 433
ASP A 399
ASP A 398
PRO A 171
None
1.49A 3fgrB-1bxnA:
0.0
3fgrB-1bxnA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fwx NITROUS OXIDE
REDUCTASE


(Paracoccus
denitrificans)
PF13473
(Cupredoxin_1)
4 ARG A 109
ASP A 455
ASP A 458
PRO A 459
None
0.90A 3fgrB-1fwxA:
undetectable
3fgrB-1fwxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
4 ARG A 263
ASP A 258
ASP A 261
PRO A 262
None
1.30A 3fgrB-1gqjA:
0.0
3fgrB-1gqjA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E


(Chondrostereum
purpureum)
PF00295
(Glyco_hydro_28)
4 ARG A 231
ASP A 265
ASP A 264
PRO A 263
GOL  A1001 (-3.9A)
None
GOL  A1001 (-2.8A)
None
1.48A 3fgrB-1k5cA:
undetectable
3fgrB-1k5cA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20)
PF00704
(Glyco_hydro_18)
4 ARG A 296
ASP A 291
ASP A 294
PRO A 295
None
1.00A 3fgrB-1kfwA:
0.0
3fgrB-1kfwA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ARG A  76
ASP A  29
ASP A  74
PRO A  75
None
1.40A 3fgrB-1o8cA:
0.0
3fgrB-1o8cA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)


(Synechococcus
elongatus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ARG A 431
ASP A 397
ASP A 396
PRO A 168
None
1.42A 3fgrB-1rblA:
0.0
3fgrB-1rblA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ryy ALPHA-AMINO ACID
ESTER HYDROLASE


(Acetobacter
pasteurianus)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
4 ARG A 483
ASP A 271
ASP A 273
PRO A 484
None
1.34A 3fgrB-1ryyA:
0.0
3fgrB-1ryyA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Halothiobacillus
neapolitanus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ARG A 424
ASP A 390
ASP A 389
PRO A 161
None
1.43A 3fgrB-1svdA:
0.0
3fgrB-1svdA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb6 (S)-ACETONE-CYANOHYD
RIN LYASE


(Hevea
brasiliensis)
PF00561
(Abhydrolase_1)
4 ARG A  46
ASP A  37
ASP A  44
PRO A  45
None
1.36A 3fgrB-1yb6A:
undetectable
3fgrB-1yb6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE


(Xanthobacter
autotrophicus)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 ARG A  42
ASP A  37
ASP A  40
PRO A  41
None
1.21A 3fgrB-2c3dA:
undetectable
3fgrB-2c3dA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 ARG A 451
ASP A 152
ASP A 159
PRO A 160
None
1.45A 3fgrB-2j2mA:
undetectable
3fgrB-2j2mA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana)
PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7)
4 ARG A 443
ASP A 192
ASP A 441
PRO A 442
None
1.50A 3fgrB-2j4dA:
undetectable
3fgrB-2j4dA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbi HEP200 PROTEIN

(Cylindrotheca
fusiformis)
no annotation 4 ARG A 516
ASP A 522
ASP A 519
PRO A 518
None
1.37A 3fgrB-2nbiA:
undetectable
3fgrB-2nbiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 POLYMYOSITIS/SCLEROD
ERMA AUTOANTIGEN 1


(Homo sapiens)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
4 ARG A  33
ASP A 147
ASP A 208
PRO A 209
None
1.43A 3fgrB-2nn6A:
undetectable
3fgrB-2nn6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q04 ACETOIN UTILIZATION
PROTEIN


(Exiguobacterium
sibiricum)
PF00583
(Acetyltransf_1)
4 ARG A 105
ASP A  70
ASP A  35
PRO A  36
None
1.09A 3fgrB-2q04A:
undetectable
3fgrB-2q04A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN


(Staphylococcus
haemolyticus;
Staphylococcus
haemolyticus)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
4 ARG B 356
ASP A 159
ASP A 156
PRO A 153
None
1.13A 3fgrB-2rhqB:
undetectable
3fgrB-2rhqB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri)
PF07201
(HrpJ)
4 ARG A 186
ASP A  80
ASP A 117
PRO A 118
None
1.11A 3fgrB-2vj5A:
undetectable
3fgrB-2vj5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE


(Archaeoglobus
fulgidus)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
4 ARG A  83
ASP A 402
ASP A 353
PRO A  85
None
1.41A 3fgrB-2ztgA:
undetectable
3fgrB-2ztgA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aty PROSTAGLANDIN F2A
SYNTHASE


(Trypanosoma
cruzi)
PF00724
(Oxidored_FMN)
4 ARG A 213
ASP A 166
ASP A 165
PRO A 217
None
1.48A 3fgrB-3atyA:
undetectable
3fgrB-3atyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgy RIBONUCLEASE

(Kitasatospora
aureofaciens)
PF00545
(Ribonuclease)
4 ARG A  96
ASP A   7
ASP A  94
PRO A  95
None
1.16A 3fgrB-3dgyA:
undetectable
3fgrB-3dgyA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dra GERANYLGERANYLTRANSF
ERASE TYPE I BETA
SUBUNIT


(Candida
albicans)
PF00432
(Prenyltrans)
4 ARG B 278
ASP B 294
ASP B 340
PRO B 341
None
ZN  B 391 (-2.0A)
None
None
1.20A 3fgrB-3draB:
undetectable
3fgrB-3draB:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM


(Mus musculus)
PF04916
(Phospholip_B)
4 ARG B 469
ASP B 488
ASP B 492
PRO B 493
7PE  B 607 (-3.4A)
None
7PE  B 607 ( 4.1A)
None
0.15A 3fgrB-3fgtB:
58.4
3fgrB-3fgtB:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
4 ARG A 469
ASP A 488
ASP A 492
PRO A 493
None
0.43A 3fgrB-3fgwA:
50.2
3fgrB-3fgwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana)
PF04371
(PAD_porph)
4 ARG A 306
ASP A 244
ASP A 247
PRO A 248
None
0.46A 3fgrB-3h7kA:
undetectable
3fgrB-3h7kA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmz PUTATIVE SUGAR
ISOMERASE


(Parabacteroides
distasonis)
PF01261
(AP_endonuc_2)
4 ARG A 183
ASP A 145
ASP A 181
PRO A 182
None
1.50A 3fgrB-3lmzA:
undetectable
3fgrB-3lmzA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myx UNCHARACTERIZED
PROTEIN PSPTO_0244


(Pseudomonas
syringae group
genomosp. 3)
PF05899
(Cupin_3)
4 ARG A  36
ASP A  27
ASP A  30
PRO A  31
None
1.34A 3fgrB-3myxA:
undetectable
3fgrB-3myxA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE


(Salmonella
enterica)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 ARG A  76
ASP A  29
ASP A  74
PRO A  75
None
1.08A 3fgrB-3nx4A:
undetectable
3fgrB-3nx4A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa)
PF00026
(Asp)
PF07966
(A1_Propeptide)
4 ARG A 315
ASP A 142
ASP A 138
PRO A 126
None
1.30A 3fgrB-3psgA:
undetectable
3fgrB-3psgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psg PEPSINOGEN

(Sus scrofa)
PF00026
(Asp)
PF07966
(A1_Propeptide)
4 ARG A 315
ASP A 142
ASP A 138
PRO A 135
None
1.41A 3fgrB-3psgA:
undetectable
3fgrB-3psgA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta)
PF00561
(Abhydrolase_1)
4 ARG A  46
ASP A  37
ASP A  44
PRO A  45
None
1.28A 3fgrB-3rksA:
undetectable
3fgrB-3rksA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE


(Pseudomonas
stutzeri)
no annotation 4 ARG A 159
ASP A 511
ASP A 514
PRO A 515
None
0.70A 3fgrB-3sbqA:
undetectable
3fgrB-3sbqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE


(Abies grandis)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 ARG A 362
ASP A 770
ASP A 769
PRO A 768
None
1.35A 3fgrB-3sdqA:
undetectable
3fgrB-3sdqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4j NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
4 ARG A  14
ASP A   9
ASP A  12
PRO A  13
None
1.23A 3fgrB-3u4jA:
undetectable
3fgrB-3u4jA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius)
PF00026
(Asp)
4 ARG A 312
ASP A 144
ASP A 140
PRO A 128
None
1.19A 3fgrB-4aa9A:
undetectable
3fgrB-4aa9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aa9 CHYMOSIN

(Camelus
dromedarius)
PF00026
(Asp)
4 ARG A 312
ASP A 144
ASP A 140
PRO A 137
None
1.39A 3fgrB-4aa9A:
undetectable
3fgrB-4aa9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda)
PF00069
(Pkinase)
4 ARG A 364
ASP A 318
ASP A 362
PRO A 363
None
MG  A 601 (-3.1A)
None
None
1.43A 3fgrB-4ix3A:
undetectable
3fgrB-4ix3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN


(Pisum sativum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 ARG A 431
ASP A 397
ASP A 396
PRO A 168
None
1.44A 3fgrB-4mkvA:
undetectable
3fgrB-4mkvA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oet PUTATIVE PEPTIDE
ABC-TRANSPORT SYSTEM
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN


(Campylobacter
jejuni)
PF00496
(SBP_bac_5)
4 ARG A 437
ASP A 131
ASP A 389
PRO A 390
None
GOL  A 506 (-3.2A)
GOL  A 506 (-4.6A)
None
0.79A 3fgrB-4oetA:
undetectable
3fgrB-4oetA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5w TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
4 ARG B 194
ASP B 190
ASP B 192
PRO B 193
None
1.33A 3fgrB-4u5wB:
undetectable
3fgrB-4u5wB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1

(Glossoscolex
paulistus)
PF16915
(Eryth_link_C)
4 ARG M 176
ASP M 200
ASP M 201
PRO M 104
None
1.21A 3fgrB-4u8uM:
undetectable
3fgrB-4u8uM:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u LINKER L1

(Glossoscolex
paulistus)
PF16915
(Eryth_link_C)
4 ARG M 176
ASP M 202
ASP M 201
PRO M 104
None
1.34A 3fgrB-4u8uM:
undetectable
3fgrB-4u8uM:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum)
PF07859
(Abhydrolase_3)
4 ARG A 230
ASP A 225
ASP A 228
PRO A 229
None
1.27A 3fgrB-4ypvA:
undetectable
3fgrB-4ypvA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a05 ALDOSE-ALDOSE
OXIDOREDUCTASE


(Caulobacter
vibrioides)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 ARG A 217
ASP A 212
ASP A 215
PRO A 216
None
1.31A 3fgrB-5a05A:
undetectable
3fgrB-5a05A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF


(Serratia sp.
FS14)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
4 ARG A 279
ASP A 268
ASP A 269
PRO A 480
None
1.02A 3fgrB-5cioA:
undetectable
3fgrB-5cioA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
4 ARG A 254
ASP A 249
ASP A 252
PRO A 253
None
1.29A 3fgrB-5jboA:
undetectable
3fgrB-5jboA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, 18 KDA
SUBUNIT
MITOCHONDRIAL
COMPLEX I, B14
SUBUNIT


(Ovis aries;
Ovis aries)
no annotation
no annotation
4 ARG g  76
ASP c  18
ASP g  74
PRO g  75
None
1.28A 3fgrB-5lnkg:
undetectable
3fgrB-5lnkg:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny5 3,4-DIHYDROXYBENZOAT
E DECARBOXYLASE


(Enterobacter
cloacae)
PF01977
(UbiD)
4 ARG A 241
ASP A   7
ASP A 213
PRO A 214
None
1.43A 3fgrB-5ny5A:
undetectable
3fgrB-5ny5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3m PROTOCATECHUATE
DECARBOXYLASE


(Klebsiella
pneumoniae)
PF01977
(UbiD)
4 ARG A 241
ASP A   7
ASP A 213
PRO A 214
None
1.36A 3fgrB-5o3mA:
undetectable
3fgrB-5o3mA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE


(Bacteroides
thetaiotaomicron)
no annotation 4 ARG A 369
ASP A 361
ASP A 367
PRO A 368
None
1.09A 3fgrB-5opjA:
undetectable
3fgrB-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
4 ARG A 316
ASP A 142
ASP A 138
PRO A 126
None
1.26A 3fgrB-5pepA:
undetectable
3fgrB-5pepA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pep PEPSIN

(Sus scrofa)
PF00026
(Asp)
4 ARG A 316
ASP A 142
ASP A 138
PRO A 135
None
1.36A 3fgrB-5pepA:
undetectable
3fgrB-5pepA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv6 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 3


(Methylophaga
aminisulfidivorans)
PF00497
(SBP_bac_3)
4 ARG A 106
ASP A 101
ASP A 104
PRO A 105
None
1.17A 3fgrB-5sv6A:
undetectable
3fgrB-5sv6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1


(synthetic
construct)
no annotation 4 ARG A  46
ASP A  37
ASP A  44
PRO A  45
None
1.35A 3fgrB-5tdxA:
undetectable
3fgrB-5tdxA:
22.38