SIMILAR PATTERNS OF AMINO ACIDS FOR 3FC6_C_REAC501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 VAL M 137
ALA M  34
LEU M 455
ALA M 456
VAL M 179
 None
 0.93A 3fc6C-1dwaM:
undetectable		 3fc6C-1dwaM:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ALA A 303
ALA A 304
LEU A 260
LEU A 416
ALA A 417
 None
 0.97A 3fc6C-1e1cA:
undetectable		 3fc6C-1e1cA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 206
CYH A 210
ALA A 212
ALA A 213
VAL A 291
 None
None
None
None
NAD  A1100 (-4.2A)
 0.87A 3fc6C-1ee2A:
undetectable		 3fc6C-1ee2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 VAL A   8
ALA A  17
ALA A  18
ALA A 316
VAL A  87
 FAD  A 699 (-4.3A)
None
None
None
None
 0.84A 3fc6C-1fcdA:
undetectable		 3fc6C-1fcdA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lv2 HEPATOCYTE NUCLEAR
FACTOR 4-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 139
GLN A 145
LEU A 179
ARG A 186
LEU A 196
 None
PLM  A 328 ( 4.8A)
PLM  A 328 ( 4.6A)
PLM  A 328 (-3.3A)
PLM  A 328 (-3.7A)
 0.78A 3fc6C-1lv2A:
23.9		 3fc6C-1lv2A:
39.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1naa CELLOBIOSE
DEHYDROGENASE

(Phanerochaete
chrysosporium) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 VAL A 222
ALA A 231
ALA A 232
ALA A 745
VAL A 441
 6FA  A 801 (-4.8A)
None
None
None
None
 0.77A 3fc6C-1naaA:
undetectable		 3fc6C-1naaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 VAL A 114
CYH A 118
ALA A 120
LEU A  81
VAL A 126
 None
 0.99A 3fc6C-1tcdA:
undetectable		 3fc6C-1tcdA:
23.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 VAL A 336
ALA A 342
ALA A 343
GLN A 346
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
CYH A 503
 None
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
MEI  A1001 (-4.0A)
 0.66A 3fc6C-1uhlA:
30.8		 3fc6C-1uhlA:
88.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uhl RETINOIC ACID
RECEPTOR RXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 VAL A 336
CYH A 340
ALA A 342
ALA A 343
GLN A 346
LEU A 380
PHE A 384
ARG A 387
LEU A 397
ALA A 398
VAL A 413
 None
None
MEI  A1001 (-3.1A)
MEI  A1001 (-3.3A)
None
MEI  A1001 (-3.8A)
MEI  A1001 (-4.5A)
MEI  A1001 (-3.6A)
MEI  A1001 ( 4.4A)
MEI  A1001 (-3.4A)
MEI  A1001 (-4.1A)
 0.59A 3fc6C-1uhlA:
30.8		 3fc6C-1uhlA:
88.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 381
ALA A 387
ALA A 388
LEU A 327
CYH A 401
 None
 0.79A 3fc6C-1w78A:
undetectable		 3fc6C-1w78A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wws HYPOTHETICAL PROTEIN
TTHA1479

(Thermus
thermophilus) 		PF09123
(DUF1931) 		6 VAL A 121
ALA A  16
ALA A  15
LEU A  11
PHE A  12
LEU A  18
 None
 1.12A 3fc6C-1wwsA:
undetectable		 3fc6C-1wwsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa0 PUTATIVE NADPH
DEPENDENT
OXIDOREDUCTASES

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N) 		5 ALA A 134
ALA A 135
LEU A 291
LEU A 165
ALA A 166
 None
 0.89A 3fc6C-1xa0A:
undetectable		 3fc6C-1xa0A:
23.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xiu RXR-LIKE PROTEIN

(Biomphalaria
glabrata) 		PF00104
(Hormone_recep) 		12 VAL A 239
CYH A 243
ALA A 245
ALA A 246
GLN A 249
LEU A 283
PHE A 287
ARG A 290
LEU A 300
ALA A 301
VAL A 316
CYH A 406
 9CR  A 201 ( 4.8A)
9CR  A 201 ( 3.8A)
9CR  A 201 (-3.6A)
9CR  A 201 (-3.6A)
9CR  A 201 (-4.1A)
9CR  A 201 ( 4.1A)
9CR  A 201 (-4.7A)
9CR  A 201 (-2.8A)
9CR  A 201 (-4.4A)
9CR  A 201 (-3.4A)
9CR  A 201 (-4.2A)
9CR  A 201 (-3.6A)
 0.35A 3fc6C-1xiuA:
31.3		 3fc6C-1xiuA:
81.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 VAL A 265
ALA A 271
GLN A 275
PHE A 313
ARG A 316
VAL A 342
 9CR  A 801 ( 4.6A)
9CR  A 801 (-3.6A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.3A)
 1.50A 3fc6C-1xlsA:
30.5		 3fc6C-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 VAL A 265
CYH A 269
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 9CR  A 801 ( 4.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-3.6A)
9CR  A 801 (-3.5A)
9CR  A 801 (-4.7A)
9CR  A 801 (-4.2A)
9CR  A 801 (-4.3A)
9CR  A 801 (-2.6A)
9CR  A 801 (-4.1A)
9CR  A 801 (-3.3A)
9CR  A 801 ( 4.3A)
9CR  A 801 ( 3.7A)
 0.38A 3fc6C-1xlsA:
30.5		 3fc6C-1xlsA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z5x ULTRASPIRACLE
PROTEIN (USP) A
HOMOLOGUE OF RXR

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		5 CYH U 304
ALA U 306
ALA U 307
LEU U 365
ALA U 362
 None
 0.84A 3fc6C-1z5xU:
22.2		 3fc6C-1z5xU:
63.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		6 VAL A 297
CYH A 301
ALA A 303
ALA A 304
LEU A 290
VAL A 271
 None
 0.89A 3fc6C-1z6rA:
undetectable		 3fc6C-1z6rA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		6 ALA A 452
ALA A 451
GLN A 453
LEU A 434
ALA A 435
VAL A 356
 None
None
GOL  A3003 ( 3.8A)
None
None
None
 1.25A 3fc6C-1zk7A:
undetectable		 3fc6C-1zk7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A  57
ALA A  58
LEU A   5
ALA A  29
VAL A 163
 None
 0.98A 3fc6C-2dpnA:
undetectable		 3fc6C-2dpnA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 VAL A  45
CYH A  49
ALA A  51
ALA A  52
LEU A 147
 None
 0.94A 3fc6C-2e3dA:
undetectable		 3fc6C-2e3dA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257

(Bacteroides
thetaiotaomicron) 		PF01661
(Macro) 		5 VAL A  20
ALA A  10
LEU A  39
ALA A  38
VAL A 107
 None
 0.98A 3fc6C-2fg1A:
undetectable		 3fc6C-2fg1A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE

(coryneform
bacterium) 		PF14832
(Tautomerase_3) 		5 VAL A  86
ALA A  92
ALA A  93
ALA A  19
VAL A 102
 None
 0.88A 3fc6C-2flzA:
undetectable		 3fc6C-2flzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flz CIS-3-CHLOROACRYLIC
ACID DEHALOGENASE

(coryneform
bacterium) 		PF14832
(Tautomerase_3) 		5 VAL A  86
ALA A  92
ALA A  93
LEU A  12
ALA A  19
 None
 0.96A 3fc6C-2flzA:
undetectable		 3fc6C-2flzA:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A  88
PHE A  92
ARG A  95
ALA A 106
VAL A 121
CYH A 211
 None
 0.73A 3fc6C-2gl8A:
28.9		 3fc6C-2gl8A:
85.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A  92
ARG A  95
LEU A 105
ALA A 106
VAL A 121
CYH A 211
 None
 0.81A 3fc6C-2gl8A:
28.9		 3fc6C-2gl8A:
85.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A  24
ALA A  33
ALA A  34
ALA A 425
VAL A 191
 None
 0.90A 3fc6C-2h88A:
undetectable		 3fc6C-2h88A:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 LEU A 255
PHE A 259
ARG A 262
ALA A 273
CYH A 378
 None
 0.95A 3fc6C-2nxxA:
25.4		 3fc6C-2nxxA:
63.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nxx ULTRASPIRACLE (USP,
NR2B4)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		5 PHE A 259
ARG A 262
LEU A 272
ALA A 273
CYH A 378
 None
 0.71A 3fc6C-2nxxA:
25.4		 3fc6C-2nxxA:
63.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 VAL A 113
ALA A 335
ALA A 336
ALA A 313
VAL A 130
 None
 1.00A 3fc6C-2o0mA:
undetectable		 3fc6C-2o0mA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 VAL A1242
ALA A1248
ALA A1249
LEU A1140
ALA A1139
 None
 0.94A 3fc6C-2oxfA:
undetectable		 3fc6C-2oxfA:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q60 RETINOID X RECEPTOR

(Polyandrocarpa
misakiensis) 		PF00104
(Hormone_recep) 		6 LEU A 184
PHE A 188
ARG A 191
ALA A 202
VAL A 217
CYH A 307
 None
 0.60A 3fc6C-2q60A:
28.3		 3fc6C-2q60A:
72.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		6 VAL A 144
ALA A 153
ALA A 147
LEU A 241
LEU A 164
ALA A 246
 None
 1.32A 3fc6C-2q74A:
undetectable		 3fc6C-2q74A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa1 POLYKETIDE OXYGENASE
PGAE

(Streptomyces
sp. PGA64) 		PF01494
(FAD_binding_3) 		5 VAL A 270
ALA A 273
LEU A 298
ALA A 295
VAL A 130
 None
 0.94A 3fc6C-2qa1A:
undetectable		 3fc6C-2qa1A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 VAL A  11
ALA A  20
ALA A  21
ALA A 444
VAL A 247
 FAD  A 600 (-4.7A)
None
None
None
None
 0.93A 3fc6C-2yg6A:
undetectable		 3fc6C-2yg6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yw9 ENOYL-[ACYL CARRIER
PROTEIN] REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		5 VAL A 245
ALA A 190
LEU A  22
LEU A 229
VAL A 171
 None
 0.99A 3fc6C-2yw9A:
undetectable		 3fc6C-2yw9A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zon CYTOCHROME C551

(Achromobacter
xylosoxidans) 		PF13442
(Cytochrome_CBB3) 		5 VAL G  79
ALA G  85
ALA G  86
LEU G  34
VAL G  55
 HEM  G 200 ( 4.5A)
None
None
None
HEM  G 200 ( 4.8A)
 1.00A 3fc6C-2zonG:
undetectable		 3fc6C-2zonG:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 6 VAL E 382
CYH E 386
ALA E 389
LEU E 394
LEU E 403
VAL E 204
 None
 1.29A 3fc6C-3aoeE:
undetectable		 3fc6C-3aoeE:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		no annotation 6 VAL E 382
CYH E 386
ALA E 389
LEU E 403
ALA E 402
VAL E 204
 None
 1.30A 3fc6C-3aoeE:
undetectable		 3fc6C-3aoeE:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 VAL A  32
ALA A  44
LEU A  20
LEU A  11
ALA A 133
 None
 1.00A 3fc6C-3b1fA:
undetectable		 3fc6C-3b1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		5 CYH B 154
ALA B 156
ALA B 157
LEU B  93
ALA B  94
 SF4  B 246 (-2.2A)
None
None
None
None
 0.98A 3fc6C-3cirB:
undetectable		 3fc6C-3cirB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8u PURR TRANSCRIPTIONAL
REGULATOR

(Vibrio
parahaemolyticus) 		PF13377
(Peripla_BP_3) 		5 VAL A 130
ALA A 311
ALA A 310
LEU A  96
ALA A  95
 None
 0.83A 3fc6C-3d8uA:
undetectable		 3fc6C-3d8uA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		5 VAL A 106
ALA A 130
ALA A 131
LEU A  98
VAL A  51
 None
 0.94A 3fc6C-3ddlA:
undetectable		 3fc6C-3ddlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 ALA A 115
ALA A 116
LEU A 220
VAL A 105
CYH A 137
 None
 0.94A 3fc6C-3djcA:
undetectable		 3fc6C-3djcA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 VAL A1200
CYH A1209
LEU A1229
LEU A1250
VAL A1197
 None
 0.93A 3fc6C-3dm0A:
undetectable		 3fc6C-3dm0A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		12 VAL A 265
CYH A 269
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 9CR  A7223 ( 4.5A)
None
9CR  A7223 (-3.5A)
9CR  A7223 (-4.2A)
9CR  A7223 (-4.6A)
9CR  A7223 ( 4.4A)
9CR  A7223 (-4.5A)
9CR  A7223 (-3.7A)
9CR  A7223 (-3.8A)
9CR  A7223 ( 4.7A)
9CR  A7223 ( 4.5A)
9CR  A7223 (-3.8A)
 0.71A 3fc6C-3dzuA:
30.3		 3fc6C-3dzuA:
51.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fs1 HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 CYH A 179
GLN A 185
LEU A 219
ARG A 226
LEU A 236
 None
None
MYR  A 500 ( 4.0A)
MYR  A 500 (-2.8A)
MYR  A 500 (-3.7A)
 0.83A 3fc6C-3fs1A:
23.8		 3fc6C-3fs1A:
38.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 299
ALA A 305
ALA A 306
ALA A 365
VAL A 174
 None
 1.00A 3fc6C-3gb0A:
undetectable		 3fc6C-3gb0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gn3 PUTATIVE
PROTEIN-DISULFIDE
ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13462
(Thioredoxin_4) 		5 VAL A  64
ALA A  69
ALA A  70
LEU A 122
ALA A 127
 None
 0.97A 3fc6C-3gn3A:
undetectable		 3fc6C-3gn3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		5 VAL A 303
ALA A 306
ALA A 178
LEU A 331
VAL A 157
 None
 0.96A 3fc6C-3ihgA:
undetectable		 3fc6C-3ihgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 VAL A  50
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
None
None
None
ADP  A 642 (-3.9A)
 0.92A 3fc6C-3k1jA:
undetectable		 3fc6C-3k1jA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		5 VAL A 121
ALA A  89
ALA A  90
LEU A 383
ALA A 384
 None
 0.89A 3fc6C-3kehA:
undetectable		 3fc6C-3kehA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		5 VAL A 160
ALA A 166
ALA A 167
LEU A 172
VAL A 150
 None
 0.97A 3fc6C-3lkbA:
undetectable		 3fc6C-3lkbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mk3 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Salmonella
enterica) 		no annotation 5 VAL A  76
ALA A 141
ALA A 140
LEU A  38
ALA A  37
 None
 0.92A 3fc6C-3mk3A:
undetectable		 3fc6C-3mk3A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngj DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Entamoeba
histolytica) 		PF01791
(DeoC) 		5 VAL A 141
CYH A 145
ALA A 147
ALA A 148
VAL A 100
 None
 0.52A 3fc6C-3ngjA:
undetectable		 3fc6C-3ngjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 VAL D 157
ALA D 295
GLN D 294
PHE D 240
VAL D 406
 ADP  D 600 (-4.0A)
SO4  D 630 ( 4.6A)
None
None
None
 0.98A 3fc6C-3oaaD:
undetectable		 3fc6C-3oaaD:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pwz SHIKIMATE
DEHYDROGENASE 3

(Pseudomonas
putida) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 VAL A 186
ALA A 227
GLN A 230
LEU A 200
ALA A 202
 None
 0.99A 3fc6C-3pwzA:
undetectable		 3fc6C-3pwzA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q15 RESPONSE REGULATOR
ASPARTATE
PHOSPHATASE H

(Bacillus
subtilis) 		PF13176
(TPR_7) 		5 VAL A 240
ALA A 246
ALA A 247
LEU A 258
ALA A 220
 None
 0.84A 3fc6C-3q15A:
undetectable		 3fc6C-3q15A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 VAL A 419
CYH A 423
ALA A 425
ALA A 426
LEU A 510
 None
 0.78A 3fc6C-3sqgA:
undetectable		 3fc6C-3sqgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 5 VAL A 188
ALA A 194
ALA A 195
GLN A 198
LEU A 237
 None
 0.63A 3fc6C-3tdgA:
undetectable		 3fc6C-3tdgA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7i PUTATIVE POLYKETIDE
SYNTHASE

(Streptomyces
coelicolor) 		PF00195
(Chal_sti_synt_N) 		5 VAL A 113
ALA A 120
ALA A 121
LEU A 198
ALA A   9
 None
 0.94A 3fc6C-3v7iA:
undetectable		 3fc6C-3v7iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT

(Thermochromatium
tepidum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind) 		5 VAL B   8
ALA B  17
ALA B  18
ALA B 316
VAL B  87
 FAD  B 501 (-4.6A)
None
None
None
None
 0.73A 3fc6C-3vrdB:
undetectable		 3fc6C-3vrdB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE

(Aquifex
aeolicus) 		PF03841
(SelA) 		5 VAL A 146
ALA A 154
ALA A 184
LEU A 210
ALA A 209
 None
 0.98A 3fc6C-3w1jA:
undetectable		 3fc6C-3w1jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 462
ALA A 426
GLN A 425
LEU A 427
VAL A 475
 None
 0.79A 3fc6C-3zzuA:
undetectable		 3fc6C-3zzuA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 CYH A 688
ALA A 691
ALA A 692
LEU A 412
LEU A 646
 None
 0.95A 3fc6C-4a0hA:
undetectable		 3fc6C-4a0hA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a25 FERRITIN DPS FAMILY
PROTEIN

(Kineococcus
radiotolerans) 		PF00210
(Ferritin) 		5 VAL A  33
ALA A  39
GLN A  43
LEU A 120
VAL A 131
 None
 0.98A 3fc6C-4a25A:
undetectable		 3fc6C-4a25A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		5 VAL A  45
CYH A  49
ALA A  51
ALA A  52
LEU A 147
 None
 0.97A 3fc6C-4d48A:
undetectable		 3fc6C-4d48A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 VAL A 117
ALA A 123
ALA A 124
LEU A 133
ALA A  58
 None
 0.98A 3fc6C-4drtA:
undetectable		 3fc6C-4drtA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		5 VAL A 137
ALA A 143
ALA A 144
LEU A 101
VAL A 181
 None
 0.92A 3fc6C-4gxwA:
undetectable		 3fc6C-4gxwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyr GLUCARATE
DEHYDRATASE

(Acidaminococcus
intestini) 		PF13378
(MR_MLE_C) 		5 VAL A 184
CYH A 188
ALA A 190
ALA A 191
LEU A 173
 None
 0.90A 3fc6C-4hyrA:
undetectable		 3fc6C-4hyrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia4 AQUAPORIN

(Spinacia
oleracea) 		PF00230
(MIP) 		5 ALA A 257
ALA A 258
GLN A 261
LEU A 110
ALA A 111
 None
 0.80A 3fc6C-4ia4A:
undetectable		 3fc6C-4ia4A:
22.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqr HEPATOCYTE NUCLEAR
FACTOR 4-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH A 179
GLN A 185
LEU A 219
ARG A 226
LEU A 236
 None
MYR  A 401 (-4.8A)
MYR  A 401 ( 4.4A)
MYR  A 401 (-3.8A)
MYR  A 401 (-3.8A)
 0.92A 3fc6C-4iqrA:
23.2		 3fc6C-4iqrA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 12 VAL D 265
CYH D 269
ALA D 271
ALA D 272
GLN D 275
LEU D 309
PHE D 313
ARG D 316
LEU D 326
ALA D 327
VAL D 342
CYH D 432
 None
 0.64A 3fc6C-4j5xD:
29.0		 3fc6C-4j5xD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jvy FEMALE
GERMLINE-SPECIFIC
TUMOR SUPPRESSOR
GLD-1

(Caenorhabditis
elegans) 		PF00013
(KH_1)
PF16544
(STAR_dimer) 		5 VAL A 287
ALA A 293
ALA A 294
GLN A 297
LEU A 236
 None
 0.80A 3fc6C-4jvyA:
undetectable		 3fc6C-4jvyA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E

(Streptomyces
rimosus) 		PF01494
(FAD_binding_3) 		5 VAL A 283
ALA A 286
LEU A 311
ALA A 308
VAL A 133
 None
 0.97A 3fc6C-4k2xA:
undetectable		 3fc6C-4k2xA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 ALA A  86
GLN A  89
LEU A  28
ALA A  13
VAL A 186
 None
 0.94A 3fc6C-4lomA:
undetectable		 3fc6C-4lomA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		5 VAL A 240
ALA A 246
ALA A 247
LEU A 138
ALA A 137
 None
 0.87A 3fc6C-4r31A:
undetectable		 3fc6C-4r31A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 VAL A  84
ALA A  90
ALA A  91
ALA A 102
VAL A 365
 None
 0.89A 3fc6C-4u4eA:
undetectable		 3fc6C-4u4eA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9n L-ALPHA-GLYCEROPHOSP
HATE OXIDASE

(Mycoplasma
pneumoniae) 		PF01266
(DAO) 		6 ALA A 209
ALA A 208
LEU A 343
LEU A 216
ALA A 213
VAL A 202
 FAD  A 401 (-3.6A)
None
None
None
None
None
 1.09A 3fc6C-4x9nA:
undetectable		 3fc6C-4x9nA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai GRUNGE, ISOFORM J
MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Drosophila
melanogaster;
Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8)
no annotation 		5 ALA A1204
ALA A1203
GLN A1205
LEU P1820
ALA P1819
 None
 0.95A 3fc6C-4xaiA:
14.8		 3fc6C-4xaiA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4n PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanotorris
igneus) 		PF01946
(Thi4) 		5 VAL A  35
ALA A  44
ALA A  45
ALA A 252
VAL A 146
 48H  A 302 (-4.9A)
None
None
None
None
 0.86A 3fc6C-4y4nA:
undetectable		 3fc6C-4y4nA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynv ACL4

(Chaetomium
thermophilum) 		PF13432
(TPR_16) 		5 ALA A  49
ALA A  50
LEU A  74
LEU A  41
ALA A  37
 None
 0.99A 3fc6C-4ynvA:
undetectable		 3fc6C-4ynvA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		5 VAL A  50
ALA A  56
ALA A  57
LEU A  84
VAL A  43
 None
 0.95A 3fc6C-4zpxA:
undetectable		 3fc6C-4zpxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens;
Mus musculus) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		5 VAL A 227
ALA A 233
ALA A 234
GLN A 237
VAL A 254
 None
 0.77A 3fc6C-4zwjA:
2.1		 3fc6C-4zwjA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azs OUTER MEMBRANE
PROTEIN OPRJ

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 VAL A 127
ALA A 133
ALA A 134
ARG A 281
ALA A 280
 None
 0.79A 3fc6C-5azsA:
undetectable		 3fc6C-5azsA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 CYH A 141
ALA A 143
ALA A 144
GLN A 147
LEU A 408
 None
 0.79A 3fc6C-5cioA:
undetectable		 3fc6C-5cioA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 CYH A 141
ALA A 143
ALA A 144
LEU A 408
LEU A 404
 None
 0.93A 3fc6C-5cioA:
undetectable		 3fc6C-5cioA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cju ISOBUTYRYL-COA
MUTASE FUSED

(Cupriavidus
metallidurans) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
PF03308
(ArgK) 		5 VAL A 295
CYH A 299
ALA A 301
ALA A 302
LEU A 200
 None
 0.77A 3fc6C-5cjuA:
undetectable		 3fc6C-5cjuA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e43 BETA-LACTAMASE

(Streptosporangium
roseum) 		PF13354
(Beta-lactamase2) 		6 VAL A 120
ALA A  77
ALA A  79
LEU A 149
ALA A  74
VAL A  96
 None
 1.41A 3fc6C-5e43A:
undetectable		 3fc6C-5e43A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7q ACYL-COA SYNTHETASE

(Streptomyces
platensis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 VAL A  67
ALA A  73
ALA A  74
LEU A  42
ALA A  43
 None
 0.63A 3fc6C-5e7qA:
undetectable		 3fc6C-5e7qA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		5 VAL B  32
ALA B  38
ALA B  39
LEU B 186
VAL B  17
 None
 0.84A 3fc6C-5exeB:
undetectable		 3fc6C-5exeB:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfi UNCHARACTERIZED
PROTEIN, CYTOSOLIC
DISULFIDE REDUCTASE
DSBM

(Pseudomonas
aeruginosa) 		PF01323
(DSBA) 		5 ALA A 149
ALA A 147
LEU A 134
LEU A 105
ALA A 101
 ALA  A 149 ( 0.0A)
ALA  A 147 ( 0.0A)
LEU  A 134 ( 0.6A)
LEU  A 105 ( 0.6A)
ALA  A 101 ( 0.0A)
 0.95A 3fc6C-5hfiA:
undetectable		 3fc6C-5hfiA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lae PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE
OXIDASE,PEROXISOMAL
N(1)-ACETYL-SPERMINE
/SPERMIDINE OXIDASE

(Mus musculus) 		PF01593
(Amino_oxidase) 		5 VAL A  11
ALA A  20
ALA A  21
ALA A 486
VAL A 263
 FAD  A1801 (-4.6A)
None
None
None
None
 0.94A 3fc6C-5laeA:
undetectable		 3fc6C-5laeA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 CYH A 163
ALA A 165
ALA A 166
LEU A  82
VAL A 154
 None
 0.89A 3fc6C-5mifA:
undetectable		 3fc6C-5mifA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		5 ALA A 189
ALA A 190
PHE A 157
LEU A 113
ALA A 116
 None
 0.96A 3fc6C-5mzyA:
undetectable		 3fc6C-5mzyA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twa BAK-2 PROTEIN
BCL-X HOMOLOGOUS
PROTEIN, BHP2

(Geodia
cydonium;
Lubomirskia
baicalensis) 		PF00452
(Bcl-2)
no annotation 		5 VAL A  87
ALA A  81
ALA A  80
LEU A  32
VAL D  82
 None
 0.96A 3fc6C-5twaA:
undetectable		 3fc6C-5twaA:
22.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 12 VAL A 265
CYH A 269
ALA A 271
ALA A 272
GLN A 275
LEU A 309
PHE A 313
ARG A 316
LEU A 326
ALA A 327
VAL A 342
CYH A 432
 None
9CR  A 503 ( 4.4A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.5A)
9CR  A 503 (-3.8A)
9CR  A 503 (-3.7A)
9CR  A 503 (-4.7A)
9CR  A 503 (-3.0A)
9CR  A 503 (-4.3A)
9CR  A 503 (-3.4A)
None
9CR  A 503 (-3.3A)
 0.58A 3fc6C-5uanA:
30.0		 3fc6C-5uanA:
66.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chj DIACYLGLYCEROL
O-ACYLTRANSFERASE

(Marinobacter
hydrocarbonoclasticus) 		no annotation 5 VAL A 266
CYH A 270
ALA A 272
ALA A 273
VAL A 421
 None
 0.62A 3fc6C-6chjA:
undetectable		 3fc6C-6chjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d95 -

(-) 		no annotation 5 ALA A 132
ALA A 133
LEU A 138
LEU A 267
ALA A 266
 None
 0.90A 3fc6C-6d95A:
undetectable		 3fc6C-6d95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 6 VAL A  53
ALA A  83
GLN A  86
PHE A  94
LEU A  88
VAL A  67
 None
 1.43A 3fc6C-6fhsA:
undetectable		 3fc6C-6fhsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fk6 RHODOPSIN

(Bos taurus) 		no annotation 5 VAL A 227
ALA A 233
ALA A 234
GLN A 237
VAL A 254
 BOG  A 410 ( 4.9A)
None
None
None
None
 0.76A 3fc6C-6fk6A:
2.3		 3fc6C-6fk6A:
15.81