SIMILAR PATTERNS OF AMINO ACIDS FOR 3FBX_A_ACTA608_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 GLU A 327
VAL A 276
CYH A 304
 None
 0.99A 3fbxA-1d0nA:
2.5		 3fbxA-1d0nA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqs PROTEIN
(3-DEHYDROQUINATE
SYNTHASE)

(Aspergillus
nidulans) 		PF01761
(DHQ_synthase) 		3 GLU A 278
VAL A 291
CYH A 290
 NAD  A 400 ( 4.8A)
None
None
 1.07A 3fbxA-1dqsA:
0.0		 3fbxA-1dqsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gan GALECTIN-1

(Rhinella
arenarum) 		PF00337
(Gal-bind_lectin) 		3 GLU A  19
VAL A  18
CYH A  89
 None
 1.06A 3fbxA-1ganA:
0.0		 3fbxA-1ganA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		3 GLU A  32
VAL A 245
CYH A   4
 None
 0.98A 3fbxA-1i60A:
0.0		 3fbxA-1i60A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jvb NAD(H)-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  69
VAL A  37
CYH A  38
 ZN  A 500 ( 3.0A)
None
ZN  A 500 ( 2.3A)
 1.00A 3fbxA-1jvbA:
0.0		 3fbxA-1jvbA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 GLU A 215
VAL A 238
CYH A 240
 None
 1.00A 3fbxA-1nfgA:
0.0		 3fbxA-1nfgA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfg D-HYDANTOINASE

(Ralstonia
pickettii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		3 GLU A 260
VAL A 310
CYH A 262
 None
 1.05A 3fbxA-1nfgA:
0.0		 3fbxA-1nfgA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 GLU A 763
VAL A 814
CYH A 817
 None
 0.79A 3fbxA-1qgrA:
0.0		 3fbxA-1qgrA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmj BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		3 GLU A  86
VAL A  19
CYH A  88
 BME  A 500 (-4.5A)
None
BME  A 500 ( 1.9A)
 1.02A 3fbxA-1qmjA:
0.0		 3fbxA-1qmjA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5t CYTIDINE DEAMINASE

(Saccharomyces
cerevisiae) 		PF00383
(dCMP_cyt_deam_1) 		3 GLU A  52
VAL A  51
CYH A  59
 None
 1.03A 3fbxA-1r5tA:
0.4		 3fbxA-1r5tA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  62
VAL A  37
CYH A  38
 None
None
ZN  A 402 (-2.2A)
 1.07A 3fbxA-1rjwA:
undetectable		 3fbxA-1rjwA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		3 GLU A1262
VAL A1264
CYH A1266
 None
 0.93A 3fbxA-1ug3A:
undetectable		 3fbxA-1ug3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 GLU A  97
VAL A  86
CYH A  95
 None
 1.00A 3fbxA-1vb3A:
undetectable		 3fbxA-1vb3A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 GLU A 180
VAL A 216
CYH A 215
 None
 0.95A 3fbxA-1we5A:
0.0		 3fbxA-1we5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wox HEME OXYGENASE 2

(Synechocystis
sp. PCC 6803) 		PF01126
(Heme_oxygenase) 		3 GLU A 204
VAL A 205
CYH A 100
 None
 1.06A 3fbxA-1woxA:
undetectable		 3fbxA-1woxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		3 GLU A 559
VAL A 533
CYH A 532
 None
 0.98A 3fbxA-1xyzA:
undetectable		 3fbxA-1xyzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		3 GLU A 603
VAL A 445
CYH A 601
 None
 0.93A 3fbxA-1yksA:
undetectable		 3fbxA-1yksA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		3 GLU A 352
VAL A 354
CYH A 356
 None
 0.93A 3fbxA-2c5uA:
undetectable		 3fbxA-2c5uA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d30 CYTIDINE DEAMINASE

(Bacillus
anthracis) 		PF00383
(dCMP_cyt_deam_1) 		3 GLU A  44
VAL A  43
CYH A  51
 None
 1.07A 3fbxA-2d30A:
undetectable		 3fbxA-2d30A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 GLU A 638
VAL A 640
CYH A 642
 None
 0.80A 3fbxA-2d3tA:
0.0		 3fbxA-2d3tA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		3 GLU X 589
VAL X 588
CYH X 587
 None
 0.86A 3fbxA-2epkX:
undetectable		 3fbxA-2epkX:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 344
VAL A 343
CYH A 365
 None
 1.07A 3fbxA-2jiiA:
undetectable		 3fbxA-2jiiA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyk M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 GLU A  26
VAL A  99
CYH A  98
 None
 0.96A 3fbxA-2nykA:
undetectable		 3fbxA-2nykA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 GLU A 164
VAL A 165
CYH A 168
 None
 0.97A 3fbxA-2prdA:
undetectable		 3fbxA-2prdA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus) 		PF05025
(RbsD_FucU) 		3 GLU A  47
VAL A  46
CYH A  41
 None
 1.04A 3fbxA-2wcuA:
undetectable		 3fbxA-2wcuA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x60 MANNOSE-1-PHOSPHATE
GUANYLYLTRANSFERASE

(Thermotoga
maritima) 		PF00483
(NTP_transferase) 		3 GLU A 203
VAL A 204
CYH A 207
 None
 0.91A 3fbxA-2x60A:
undetectable		 3fbxA-2x60A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z87 CHONDROITIN SYNTHASE

(Escherichia
coli) 		PF00535
(Glycos_transf_2) 		3 GLU A 463
VAL A 489
CYH A 465
 None
 0.96A 3fbxA-2z87A:
undetectable		 3fbxA-2z87A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b47 METHYL-ACCEPTING
CHEMOTAXIS PROTEIN

(Geobacter
sulfurreducens) 		no annotation 3 GLU A 136
VAL A 137
CYH A 139
 None
None
HEM  A 199 (-1.8A)
 0.73A 3fbxA-3b47A:
undetectable		 3fbxA-3b47A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		3 GLU A 107
VAL A 106
CYH A 104
 None
 0.98A 3fbxA-3b7yA:
undetectable		 3fbxA-3b7yA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnx UNCHARACTERIZED
PROTEIN

(Streptomyces
avermitilis) 		PF13474
(SnoaL_3) 		3 GLU A 109
VAL A 133
CYH A 107
 UNL  A 201 (-3.0A)
None
None
 0.89A 3fbxA-3cnxA:
undetectable		 3fbxA-3cnxA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmo CYTIDINE DEAMINASE

(Burkholderia
pseudomallei) 		PF00383
(dCMP_cyt_deam_1) 		3 GLU A  44
VAL A  43
CYH A  51
 MRD  A 132 (-3.6A)
None
MRD  A 132 ( 4.6A)
 1.02A 3fbxA-3dmoA:
undetectable		 3fbxA-3dmoA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM

(Homo sapiens) 		no annotation 3 GLU B 407
VAL B 397
CYH B 398
 None
 0.93A 3fbxA-3dw8B:
undetectable		 3fbxA-3dw8B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew5 MACRO DOMAIN OF
NON-STRUCTURAL
PROTEIN 3

(Alphacoronavirus
1) 		PF01661
(Macro) 		3 GLU A 135
VAL A 168
CYH A 172
 None
 0.99A 3fbxA-3ew5A:
undetectable		 3fbxA-3ew5A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		3 GLU A 143
VAL A 140
CYH A 138
 None
 1.08A 3fbxA-3f6tA:
undetectable		 3fbxA-3f6tA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7q INTEGRIN BETA-4

(Homo sapiens) 		PF00041
(fn3) 		3 GLU A1254
VAL A1273
CYH A1256
 1PE  A 703 (-3.1A)
None
None
 0.99A 3fbxA-3f7qA:
undetectable		 3fbxA-3f7qA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g33 CCND3 PROTEIN

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		3 GLU B 236
VAL B 237
CYH B 239
 None
 0.92A 3fbxA-3g33B:
undetectable		 3fbxA-3g33B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gl1 HEAT SHOCK PROTEIN
SSB1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		3 GLU A 370
VAL A  39
CYH A  20
 None
 1.02A 3fbxA-3gl1A:
0.2		 3fbxA-3gl1A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbn UDP-SUGAR HYDROLASE

(Campylobacter
jejuni) 		no annotation 3 GLU A 257
VAL A 253
CYH A 251
 None
 0.82A 3fbxA-3hbnA:
undetectable		 3fbxA-3hbnA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjh TRANSCRIPTION-REPAIR
-COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 GLU A 216
VAL A 117
CYH A 118
 None
 1.08A 3fbxA-3hjhA:
undetectable		 3fbxA-3hjhA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		3 GLU A  30
VAL A  29
CYH A  28
 None
 1.06A 3fbxA-3hu5A:
undetectable		 3fbxA-3hu5A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lda DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		3 GLU A 176
VAL A 175
CYH A 159
 None
 1.04A 3fbxA-3ldaA:
undetectable		 3fbxA-3ldaA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		3 GLU A 219
VAL A 254
CYH A 256
 None
 0.98A 3fbxA-3n5mA:
undetectable		 3fbxA-3n5mA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxk CYTOPLASMIC
L-ASPARAGINASE

(Campylobacter
jejuni) 		PF00710
(Asparaginase) 		3 GLU A 300
VAL A 285
CYH A 284
 None
 1.06A 3fbxA-3nxkA:
undetectable		 3fbxA-3nxkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		3 GLU A 143
VAL A  80
CYH A 145
 None
 1.05A 3fbxA-3r4cA:
undetectable		 3fbxA-3r4cA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2g ZINC-CONTAINING
ALCOHOL
DEHYDROGENASE
SUPERFAMILY

(Cupriavidus
pinatubonensis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  66
VAL A  41
CYH A  42
 ZN  A 500 (-3.2A)
None
ZN  A 500 (-2.5A)
 1.06A 3fbxA-3s2gA:
0.4		 3fbxA-3s2gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3son HYPOTHETICAL NUDIX
HYDROLASE

(Listeria
monocytogenes) 		PF00293
(NUDIX) 		3 GLU A  89
VAL A   7
CYH A  91
 None
 0.99A 3fbxA-3sonA:
undetectable		 3fbxA-3sonA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tm9 BACTERIAL HEMOGLOBIN

(Vitreoscilla
stercoraria) 		PF00042
(Globin) 		3 GLU A 137
VAL A  83
CYH A  86
 None
 1.05A 3fbxA-3tm9A:
undetectable		 3fbxA-3tm9A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		3 GLU A 108
VAL A  19
CYH A 106
 None
ADP  A 301 ( 4.9A)
None
 1.02A 3fbxA-3wv7A:
undetectable		 3fbxA-3wv7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv7 HMD CO-OCCURRING
PROTEIN HCGE

(Methanothermobacter
marburgensis) 		PF00899
(ThiF) 		3 GLU A 108
VAL A 107
CYH A 106
 None
 1.07A 3fbxA-3wv7A:
undetectable		 3fbxA-3wv7A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwp (S)-HYDROXYNITRILE
LYASE

(Baliospermum
montanum) 		PF00561
(Abhydrolase_1) 		3 GLU A 205
VAL A 230
CYH A 229
 None
 0.97A 3fbxA-3wwpA:
undetectable		 3fbxA-3wwpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  68
VAL A  69
CYH A  70
 None
 1.06A 3fbxA-4bbmA:
undetectable		 3fbxA-4bbmA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bp8 OLIGOPEPTIDASE B

(Trypanosoma
brucei) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		3 GLU A 384
VAL A 445
CYH A 446
 None
 0.89A 3fbxA-4bp8A:
undetectable		 3fbxA-4bp8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		3 GLU A 173
VAL A 174
CYH A 177
 None
 1.00A 3fbxA-4c25A:
undetectable		 3fbxA-4c25A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		3 GLU A  63
VAL A  62
CYH A 101
 CS2  A 402 (-3.6A)
None
CS2  A 402 ( 4.3A)
 1.01A 3fbxA-4eayA:
undetectable		 3fbxA-4eayA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eex ALCOHOL
DEHYDROGENASE 1

(Lactococcus
lactis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  61
VAL A  38
CYH A  39
 None
None
ZN  A 402 (-2.2A)
 1.09A 3fbxA-4eexA:
0.5		 3fbxA-4eexA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eye PROBABLE
OXIDOREDUCTASE

(Mycobacteroides
abscessus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  64
VAL A  39
CYH A  40
 None
 1.04A 3fbxA-4eyeA:
0.4		 3fbxA-4eyeA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 181
VAL A 351
CYH A 347
 None
 0.90A 3fbxA-4i6fA:
undetectable		 3fbxA-4i6fA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id2 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15889
(DUF4738) 		3 GLU A 126
VAL A 144
CYH A 145
 None
None
EDO  A 202 (-3.1A)
 1.02A 3fbxA-4id2A:
undetectable		 3fbxA-4id2A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 GLU A 141
VAL A 368
CYH A 371
 None
 1.06A 3fbxA-4it1A:
undetectable		 3fbxA-4it1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iws PA0254

(Pseudomonas
aeruginosa) 		PF01977
(UbiD) 		3 GLU A 316
VAL A 310
CYH A 309
 None
 0.95A 3fbxA-4iwsA:
undetectable		 3fbxA-4iwsA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo8 M157

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		3 GLU A  49
VAL A 122
CYH A 121
 None
 1.02A 3fbxA-4jo8A:
0.1		 3fbxA-4jo8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks9 MALONYL-COA
DECARBOXYLASE

(Cupriavidus
metallidurans) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 GLU A 255
VAL A 254
CYH A 238
 None
 0.99A 3fbxA-4ks9A:
undetectable		 3fbxA-4ks9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		3 GLU A 227
VAL A 228
CYH A 231
 None
 1.08A 3fbxA-4l7aA:
undetectable		 3fbxA-4l7aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mln PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		3 GLU A  95
VAL A  97
CYH A  99
 None
 1.08A 3fbxA-4mlnA:
undetectable		 3fbxA-4mlnA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6w PREDICTED HD
PHOSPHOHYDROLASE
PHNZ

(uncultured
bacterium
HF130_AEPn_1) 		PF01966
(HD) 		3 GLU A  95
VAL A  97
CYH A  99
 None
 1.07A 3fbxA-4n6wA:
undetectable		 3fbxA-4n6wA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmi ECTD

(Virgibacillus
salexigens) 		PF05721
(PhyH) 		3 GLU A 150
VAL A 213
CYH A 193
 None
 1.06A 3fbxA-4nmiA:
undetectable		 3fbxA-4nmiA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r27 GLYCOSIDE HYDROLASE

(Microbacterium
sp. Gsoil167) 		PF00232
(Glyco_hydro_1) 		3 GLU A 324
VAL A 364
CYH A 367
 None
 0.99A 3fbxA-4r27A:
undetectable		 3fbxA-4r27A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8l UNCHARACTERIZED
PROTEIN

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 GLU A 171
VAL A 172
CYH A 173
 None
 1.05A 3fbxA-4r8lA:
undetectable		 3fbxA-4r8lA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmp ALLOPHYCOCYANIN

(Phormidium
rubidum) 		PF00502
(Phycobilisome) 		3 GLU A 128
VAL A 130
CYH A 132
 None
 0.88A 3fbxA-4rmpA:
undetectable		 3fbxA-4rmpA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		3 GLU A 218
VAL A 241
CYH A 243
 None
 0.91A 3fbxA-4tqtA:
undetectable		 3fbxA-4tqtA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0j ACYL-[ACYL-CARRIER-P
ROTEIN] DESATURASE,
CHLOROPLASTIC

(Ricinus
communis) 		PF03405
(FA_desaturase_2) 		3 GLU A 142
VAL A  58
CYH A  61
 None
 1.05A 3fbxA-4v0jA:
undetectable		 3fbxA-4v0jA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 GLU A1054
VAL A1052
CYH A1047
 None
 1.09A 3fbxA-4xgtA:
undetectable		 3fbxA-4xgtA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xly UNCHARACTERIZED
PROTEIN BLR2150

(Bradyrhizobium
diazoefficiens) 		no annotation 3 GLU A  67
VAL A 171
CYH A 174
 None
 0.93A 3fbxA-4xlyA:
undetectable		 3fbxA-4xlyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydq PROLINE--TRNA LIGASE

(Plasmodium
falciparum) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		3 GLU A 563
VAL A 574
CYH A 573
 None
 0.92A 3fbxA-4ydqA:
undetectable		 3fbxA-4ydqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6k ALCOHOL
DEHYDROGENASE

(Moraxella sp.
TAE123) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A  62
VAL A  37
CYH A  38
 ZN  A 401 (-3.6A)
None
ZN  A 401 (-2.2A)
 1.06A 3fbxA-4z6kA:
undetectable		 3fbxA-4z6kA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz3 M64R

(Myxoma virus) 		PF03287
(Pox_C7_F8A) 		3 GLU A  94
VAL A  93
CYH A  42
 BME  A 301 (-4.3A)
None
BME  A 301 (-1.8A)
 1.06A 3fbxA-5cz3A:
undetectable		 3fbxA-5cz3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dne L-ASPARAGINASE

(Cavia porcellus) 		PF00710
(Asparaginase) 		3 GLU A 171
VAL A 172
CYH A 173
 None
 1.05A 3fbxA-5dneA:
undetectable		 3fbxA-5dneA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		3 GLU A1054
VAL A1052
CYH A1047
 None
 1.01A 3fbxA-5e02A:
undetectable		 3fbxA-5e02A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		3 GLU D 218
VAL D 219
CYH D 222
 None
 1.02A 3fbxA-5exrD:
undetectable		 3fbxA-5exrD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 GLU A 967
VAL A 891
CYH A 965
 None
 1.06A 3fbxA-5f1zA:
undetectable		 3fbxA-5f1zA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		3 GLU A  62
VAL A  32
CYH A  35
 None
 0.81A 3fbxA-5f5oA:
undetectable		 3fbxA-5f5oA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 GLU h 419
VAL h 420
CYH h 423
 None
 1.02A 3fbxA-5gw5h:
undetectable		 3fbxA-5gw5h:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxb NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		3 GLU B   6
VAL B   5
CYH B  22
 None
 1.06A 3fbxA-5gxbB:
undetectable		 3fbxA-5gxbB:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 GLU A 386
VAL A 286
CYH A 302
 None
 0.71A 3fbxA-5k6oA:
1.0		 3fbxA-5k6oA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		3 GLU A 845
VAL A 773
CYH A 774
 None
 1.07A 3fbxA-5l46A:
undetectable		 3fbxA-5l46A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		3 GLU A 256
VAL A 255
CYH A 287
 None
 1.01A 3fbxA-5m10A:
undetectable		 3fbxA-5m10A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlh -

(-) 		no annotation 3 GLU A 112
VAL A 113
CYH A 116
 None
 1.00A 3fbxA-5mlhA:
undetectable		 3fbxA-5mlhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nag KYNURENINE
3-MONOOXYGENASE

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		3 GLU A 449
VAL A 450
CYH A 453
 None
 0.95A 3fbxA-5nagA:
undetectable		 3fbxA-5nagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLU A  54
VAL A  55
CYH A  58
 None
 1.02A 3fbxA-5nd5A:
undetectable		 3fbxA-5nd5A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 3 GLU A 209
VAL A 233
CYH A 211
 None
 1.01A 3fbxA-5nf4A:
undetectable		 3fbxA-5nf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ua0 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 GLU A 158
VAL A 193
CYH A 196
 None
 0.93A 3fbxA-5ua0A:
undetectable		 3fbxA-5ua0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 GLU A 546
VAL A 547
CYH A 550
 None
 0.97A 3fbxA-5uj7A:
undetectable		 3fbxA-5uj7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF00004
(AAA)
PF09079
(Cdc6_C) 		3 GLU A 546
VAL A 547
CYH A 550
 None
 0.97A 3fbxA-5ujmA:
undetectable		 3fbxA-5ujmA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdh KINESIN-LIKE PROTEIN
KIFC1

(Homo sapiens) 		PF00225
(Kinesin) 		3 GLU A 512
VAL A 507
CYH A 509
 None
 1.01A 3fbxA-5wdhA:
undetectable		 3fbxA-5wdhA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 3 GLU A 778
VAL A 657
CYH A 782
 None
 1.05A 3fbxA-5wmmA:
undetectable		 3fbxA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy VOLTAGE-GATED SODIUM
CHANNEL BETA SUBUNIT
1

(Electrophorus
electricus) 		no annotation 3 GLU B 180
VAL B 182
CYH B 184
 None
 1.05A 3fbxA-5xsyB:
undetectable		 3fbxA-5xsyB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 3 GLU A  70
VAL A  45
CYH A  46
 ZN  A 404 (-2.9A)
None
ZN  A 404 (-2.2A)
 1.00A 3fbxA-5yatA:
undetectable		 3fbxA-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 3 GLU A 415
VAL A 416
CYH A 419
 None
 0.94A 3fbxA-6bk1A:
undetectable		 3fbxA-6bk1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A1722
VAL A1725
CYH A1726
 None
 1.08A 3fbxA-6emkA:
undetectable		 3fbxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gun -

(-) 		no annotation 3 GLU A 278
VAL A 283
CYH A 286
 None
 0.99A 3fbxA-6gunA:
undetectable		 3fbxA-6gunA:
undetectable